Globus Hystericus
Globus Sensation
Globus Pharyngeus

A feeling of a lump in the throat that occurs between meals in the absence of other gastrointestinal and motility disorders (e.g., DYSPHAGIA; GASTROESOPHAGEAL REFLUX).


Junctional Adhesion Molecule 3
Junctional Adhesion Molecule C

A junctional adhesion molecule subtype that is expressed at high levels in PLACENTA; BRAIN; KIDNEY; and PLATELETS. It serves a variety of functions such as mediating leukocyte-platelet interactions, regulating trans-epithelial migration of POLYMORPHONUCLEAR LEUKOCYTES, and acting as a counter receptor for ALPHAM INTEGRIN.


Refers to animals in the period of time just after birth.


Insurance, Disability
Disability Insurance

Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)


Receptors, Catecholamine
Catecholamine Receptor
Receptors, Catecholamines
Catecholamine Receptors

Cell surface proteins that bind catecholamines with high affinity and trigger intracellular changes which influence the behavior of cells. The catecholamine messengers epinephrine, norepinephrine, and dopamine are synthesized from tyrosine by a common biosynthetic pathway.


Congenital or developmental anomaly in which the eyeballs are abnormally small.


Hairy-Like Transcription Factor
Transcription Factor HES-1
Hairy and Enhancer of Split 1 Protein

A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.


Speech and Language Disorder Rehabilitation

Rehabilitation of Speech and Language Disorders

Language and Speech Disorder Rehabilitation

Procedures for assisting a person with a speech or language disorder to communicate with maximum efficiency.


Cinnamon
Cinnamomum zeylanicum
Cinnamomum verum

The dried inner bark of the Cinnamon tree is used medicinally and in SPICES.


Therapy, Photodynamic
Photodynamic Therapy
Photochemotherapy

Therapy using oral or topical photosensitizing agents with subsequent exposure to light.


Relapse Prevention
Secondary Disease Prevention
Secondary Prevention
Disease Prevention, Secondary
Early Therapy

Procedures undertaken to prevent or reduce the incidence or progression of disease, in individuals with EARLY DIAGNOSIS of disease, or known DISEASE SUSCEPTIBILITY.


Encounter Groups
Sensitivity Training Groups
T-Groups

A group of people who meet in an unstructured setting to learn about themselves, interpersonal relationships, and group processes and about larger social systems.


The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.


Caspase Activation and Recruitment Domain Signaling Proteins

A family of intracellular signaling adaptor proteins that contain CASPASE ACTIVATION AND RECRUITMENT DOMAINS (CARD). They play a role in APOPTOSIS-related signal transduction by associating with other CARD domain-containing members and activating INITIATOR CASPASES that contain CARD domains within their N-terminal pro-domain region.


Dopamine Plasma Membrane Transport Proteins

Solute Carrier Family 6 (Neurotransmitter Transporter), Member 3 Protein

Dopamine Plasma Membrane Transporter Proteins

Neurotransmitter Transport Proteins, Dopamine-Specific

A dopamine plasma membrane transporter protein complex located on the membrane of dopaminergic neurons. The complex includes homo-oligomers of the DAT Dopamine Transporter.


Cannabinoid Receptor Antagonists
Cannabinoid Receptor Blockers
Cannabinoid Blockers
Cannabinoid Antagonists

Compounds that inhibit or block the activity of CANNABINOID RECEPTORS.


Idiopathic Perniosis
Perniosis
Pernio
Chilblains

Recurrent localized itching, swelling and painful erythema on the fingers, toes or ears, produced by exposure to cold.


11 beta-Hydroxysteroid Dehydrogenase
Cortisone 11-Oxoreductase
11-Hydroxysteroid Dehydrogenase
11beta-Hydroxysteroid Dehydrogenase
Corticosteroid 11-Reductase
11-beta-Hydroxysteroid Dehydrogenases
Corticosteroid 11-Oxidoreductase
11B-Hydroxysteroid Dehydrogenase

Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.


Neonatal Early-Onset Sepsis
Neonatal Sepsis
Sepsis, Neonatal
Neonatal Late-Onset Sepsis

Blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age.


Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.


Sulfur-Sulfur Bond Isomerases
S-S Bond Isomerases

Enzymes that catalyze the transposition of a sulfur-sulfur bond. EC 5.3.4.


Immunoprecipitation, Chromatin
Chromatin Immunoprecipitation

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.


Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.


Systemic Lupus Erythematosus
Lupus Erythematosus Disseminatus
Libman-Sacks Disease
Lupus Erythematosus, Systemic

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.


A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.


A plant genus of the family BRASSICACEAE used for its hot peppery root.


Refractive Surgical Procedures
Refractive Surgery
Keratorefractive Surgical Procedures

Surgical procedures employed to correct REFRACTIVE ERRORS such as MYOPIA; HYPEROPIA; or ASTIGMATISM. These may involve altering the curvature of the CORNEA; removal or replacement of the CRYSTALLINE LENS; or modification of the SCLERA to change the axial length of the eye.


A myogenic regulatory factor that controls myogenesis. Though it is not clear how its function differs from the other myogenic regulatory factors, MyoD appears to be related to fusion and terminal differentiation of the muscle cell.


Thalassemia-alpha
A-Thalassemia
alpha-Thalassemia
Hemoglobin H Disease
Alpha Thalassemia

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.


A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.


Dicarboxylic Amino Acids
Amino Acids, Dicarboxylic


Myosin A
Myosin Type IIA, Non-Muscle
Myosin IIA
Non-muscle Myosin Type IIA
Nonmuscle Myosin Type IIA

A nonmuscle isoform of myosin type II found predominantly in platelets, lymphocytes, neutrophils and brush border enterocytes.


Drug Withdrawals Due to Safety
Safety-Based Drug Withdrawals
Safety-Based Drug Withdrawal
Drug Withdrawal Due to Safety

Removal of a drug from the market due to the identification of an intrinsic property of the drug that results in a serious risk to public health.


Kardiotrast Cardiotrast Iodopyracet Diodone Diodrast

An ionic monomeric contrast medium that was formerly used for a variety of diagnostic procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)


Respiratory Therapy Department, Hospital

Respiratory Therapy Departments, Hospital

Hospital department which is responsible for the administration of diagnostic pulmonary function tests and of procedures to restore optimum pulmonary ventilation.


Hemiparaplegic Syndrome
Spastic Spinal Monoplegia Syndrome
Hemicord Syndrome
Brown-Sequard Syndrome
Brown-Sequard's Paralysis
Brown-Sequard Disease
Brown-Sequard's Disease
Brown-Sequard's Syndrome
Hemispinal Cord Syndrome

A syndrome associated with injury to the lateral half of the spinal cord. The condition is characterized by the following clinical features (which are found below the level of the lesion): contralateral hemisensory anesthesia to pain and temperature, ipsilateral loss of propioception, and ipsilateral motor paralysis. Tactile sensation is generally spared. (From Adams et al., Principles of Neurology, 6th ed, p162).


Schizencephaly
Schizencephalic Cleft
Schizencephalic Cyst

Cortical malformations characterized by grey matter-lined cleft or cyst that extends from the EPENDYMA often to the PIA MATER outer surface. The grey matter that lines the cleft is often POLYMICROGYRIA. It is associated with developmental delay, motor disturbance and seizures.


Hemorrhage, Retrobulbar
Retrobulbar Hemorrhage

Hemorrhage within the orbital cavity, posterior to the eyeball.


Germ Cells
Gametes
Germ-Line Cells
Germ Line

The forms of the GERM CELLS at the final stages of GAMETOGENESIS.


An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).


Blood Vessel Prosthesis Implantation
Vascular Prosthesis Implantation
Implantation, Blood Vessel Prosthesis

Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.


Influenza A Virus, H7N7 Subtype
H7N7 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 7 and neuraminidase 7. The H7N7 subtype produced an epidemic in 2003 which was highly pathogenic among domestic birds (POULTRY). Some infections in humans were reported.


Complement Component 1r
Complement 1r
C1r Complement
Complement C1r

A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.


Acute Rheumatic Fever
Inflammatory Rheumatism
Polyarthritis Rheumatica
Arthritis, Rheumatic, Acute
Rheumatism, Articular, Acute
Arthritis, Acute Rheumatic
Rheumatic Arthritis
Rheumatism, Acute Articular
Rheumatic Fever

A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.


AKR1B10 Protein
Aldose Reductase-Like Protein
Aldose Reductase-Related Protein
Aldo-Keto Reductase Family 1 member B10

Aldo-keto reductase that functions as an all-trans-retinaldehyde reductase. It also reduces aromatic and aliphatic ALDEHYDES.


The scroll-like bony plates with curved margins on the lateral wall of the NASAL CAVITY. Turbinates, also called nasal concha, increase the surface area of nasal cavity thus providing a mechanism for rapid warming and humidification of air as it passes to the lung.


A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as a nematocide.


Abetalipoproteinemia, Normotriglyceridemic, Steinbert Type

Hypobetalipoproteinemia, Familial, Apo B

Hypobetalipoproteinemia, Familial, Apolipoprotein B

An autosomal dominant disorder of lipid metabolism. It is caused by mutations of APOLIPOPROTEINS B, main components of CHYLOMICRONS and BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include abnormally low LDL, normal triglyceride level, and dietary fat malabsorption.


Tuberculosis, Male Genital
Male Genital Tuberculosis

MYCOBACTERIUM infections of the male reproductive tract (GENITALIA, MALE).


Antigens, CD49d
alpha4 Integrin
Integrin alpha4
CD49d Antigen
CD49d Antigens

An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits.


Phenylmethylene Derivatives
Benzylidene Compounds
Benzylidene Derivatives

Compounds which include a double-bonded carbon atom that is directly attached to a benzene ring. While this category is named after the highly-reactive compound benzylidene, the compounds listed under it occur through a variety of synthetic pathways.


A plant genus of the family FUMARIACEAE (classified by some in PAPAVERACEAE) that contains isoquinoline alkaloids.


Nuclear Factor (Erythroid-Derived 2), 45kDa

A tissue-specific subunit of NF-E2 transcription factor that interacts with small MAF PROTEINS to regulate gene expression. P45 NF-E2 protein is expressed primarily in MEGAKARYOCYTES; ERYTHROID CELLS; and MAST CELLS.


Heart Disease, Ischemic
Myocardial Ischemia
Ischemia, Myocardial
Ischemic Heart Disease

A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).


A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)


Proto-Oncogene Protein B-raf
BRAF Kinases
Proto-Oncogene Proteins B-raf
B-raf Kinases

A raf kinase subclass found at high levels in neuronal tissue. The B-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.


A pelvic hernia through the obturator foramen, a large aperture in the hip bone normally covered by a membrane. Obturator hernia can lead to intestinal incarceration and INTESTINAL OBSTRUCTION.


Myelin P2 Protein
Peripheral Myelin Protein 2

A positively charged protein found in peripheral nervous system MYELIN. Sensitive immunological techniques have demonstrated that P2 is expressed in small amounts of central nervous system myelin sheaths of some species. It is an antigen for experimental allergic neuritis (NEURITIS, EXPERIMENTAL ALLERGIC), the peripheral nervous system counterpart of experimental allergic encephalomyelitis. (From Siegel et al., Basic Neurochemistry, 5th ed, p133)


Prostaglandin A Analogues
Prostaglandins A, Synthetic
PGA Synthetic
Prostaglandin A Analogs
Synthetic Prostaglandins A

Analogs or derivatives of prostaglandin A that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGA.


Satellite Cells, Skeletal Muscle
Satellite Cells, Myogenic
Skeletal Muscle Satellite Cells

Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.


Histology, Comparative
Comparative Histology

The study of the similarities and differences in the structures of homologous tissues across various species.


Dentoalveolar Abscess, Apical
Alveolar Abscess, Apical
Periapical Abscess
Periodontitis, Apical, Suppurative
Abscess, Periapical
Periapical Periodontitis, Suppurative

Acute or chronic inflammation of tissues surrounding the apical portion of a tooth, associated with the collection of pus, resulting from infection following pulp infection through a carious lesion or as a result of an injury causing pulp necrosis. (Dorland, 27th ed)


The number of CELLS of a specific kind, usually measured per unit volume or area of sample.


Cytochrome P450 Family 7
CYP7 Enzymes
CYP7 Family

A cytochrome P450 enzyme family whose members function as steroid 7-alpha hydroxylases.


Cough Suppressants
Antitussive Agents
Antitussive Drugs
Antitussives

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.


Propanol
Alcohol, Propyl
n-Propanol
1-Propanol

A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.


Proto-Oncogene Protein c-kit
p145 c-kit
p145c-kit
SCF Receptor
Antigens, CD117
Receptor, Stem Cell Factor
Stem Cell Factor Receptor
kit Proto-Oncogene Protein
p145(c-kit)
c-kit Receptor
CD117 Antigen
Proto-Oncogene Protein kit
Proto-Oncogene Proteins c-kit
c-kit Protein
CD117 Antigens

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.


Parasitic Eye Infections
Eye Infections, Parasitic
Ocular Infections, Parasitic

Mild to severe infections of the eye and its adjacent structures (adnexa) by adult or larval protozoan or metazoan parasites.


alpha-Endorphin
Endorphin, alpha
beta-Endorphin (1-16)

An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 16-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from GAMMA-ENDORPHIN by one amino acid (beta-endorphin 1-17).


Telerehabilitation
Virtual Rehabilitation
Tele-rehabilitation
Remote Rehabilitation

Delivery of therapeutic rehabilitation at a distance or offsite using telecommunication technologies.


Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.


Gene Knock-Out Techniques
Gene Knockout
Gene Knockout Techniques
Gene Knock Out
Gene Knock Out Techniques

Techniques to alter a gene sequence that result in an inactivated gene, or one in which the expression can be inactivated at a chosen time during development to study the loss of function of a gene.


Potassium Channels
Potassium Ion Channels
Ion Channel, Potassium
Potassium Channel
Ion Channels, Potassium

Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.


HTLV-I-Associated Myelopathy-Tropical Spastic Paraparesis

Myelopathy, Human T-Lymphotropic Virus Type 1 Associated

Human T-Lymphotropic Virus Type 1 Associated Myelopathy

Familial Spastic Paraparesis, Htlv-1-Associated

A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)


Glycine Sarcosine N-Methyltransferase
Glycine Sarcosine Methyltransferase
Glycine Methyltransferase
Glycine N-Methyltransferase

An enzyme that catalyzes the METHYLATION of GLYCINE using S-ADENOSYLMETHIONINE to form SARCOSINE with the concomitant production of S-ADENOSYLHOMOCYSTEINE.


Hand-Assisted Laparoscopic Surgical Procedures

Placement of one of the surgeon's gloved hands into the ABDOMINAL CAVITY to perform manual manipulations that facilitate the laparoscopic procedures.


Cell Nucleus Division
Nuclear Division
Cell Nucleus Division Phases
Karyokinesis

The process by which the CELL NUCLEUS is divided.


Nerve Lengthening
Nerve Expansion
Nerve Elongation Procedures
Nerve Stretching

Procedures that stimulate nerve elongation over a period of time. They are used in repairing nerve tissue.


Fibrous Tissue Neoplasms
Neoplasms, Fibrous Tissue

Neoplasms composed of fibrous tissue, the ordinary connective tissue of the body, made up largely of yellow or white fibers. The concept does not refer to neoplasms located in fibrous tissue.


Inanimate physical models which bear likeness to human beings and are used for various purposes in place of humans.


Data Sets as Topic
Datasets as Topic
Dataset as Topic

Subject matter related to the curation of data from research projects, stored permanently in a formalized manner suitable for communication, interpretation, or processing.


Swi-Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily B Member 1

A component of the SWI-SNF CHROMATIN REMODELING complex that functions  as a PROTEIN PHOSPHATASE 1 regulator and to stabilize CHROMATIN at PROMOTER REGIONS. It is important for regulating CELL PROLIFERATION and CELL DIFFERENTIATION. Mutations in the SMARCB1 gene are associated with malignant RHABDOID TUMORS.


The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.


RED-S Relative Energy Deficiency in Sport

Health disorders associated with low caloric intake of individuals involved in high-activity SPORTS.


Fermented Milk Products
Fermented Dairy Products
Milk Products, Cultured
Cultured Milk Products

Derivatives of milk that are produced by controlled FERMENTATION.


Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.


Dictyosteliida
Slime Molds, Cellular
Dictyostelid Cellular Slime Molds

An order of protozoa characterized by their ability to aggregate to form a multicellular pseudoplasmodium, which gives rise to a multispored fruiting body. A stalk tube is present.


Mannosidase Deficiency Diseases
Mannosidosis
Mannosidase Deficiency Syndromes

Diseases caused by the loss of one or more enzymes involved in the hydrolysis of mannoside linkages (MANNOSIDASES). The defects in enzyme activity are primarily associated with genetic mutation of the genes that codes for a particular mannosidase isoenzyme.


Surgical Arteriovenous Shunt
Shunt, Surgical Arteriovenous
Arteriovenous Shunt, Surgical

Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)


Cis-Trans Test
Cis Test
Complementation Test
Trans Test
Genetic Complementation Test
Allelism Test

A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.


A plant genus of the family ASTERACEAE that has long been used in folk medicine for treating wounds.


Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.


The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.


Shared Hospital Services
Shared Services, Hospital
Services, Shared Hospital
Hospital Services, Shared
Hospital Shared Services
Services, Hospital Shared

Cooperation among hospitals for the purpose of sharing various departmental services, e.g., pharmacy, laundry, data processing, etc.


Maternal Effect
Inherited Maternally
Maternal Inheritance
Maternally Inherited

Transmission of genetic characters, qualities, and traits, solely from maternal extra-nuclear elements such as MITOCHONDRIAL DNA or MATERNAL MESSENGER RNA.


NADP-Dependent beta-Keto Acyl Carrier Protein Reductase

A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS.


C1q Complement
Complement C1q
Complement Component 1q
Complement 1q

A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.


Removal of moisture from a substance (chemical, food, tissue, etc.).


Sulfaguanidine
Gastro-Entericanis Biocanina
Veto-centre
Sulphaguanidine

A sulfanilamide antimicrobial agent that is used to treat enteric infections.


An artemisinin derivative that is used in the treatment of MALARIA.


Polyisoprenyl Phosphate Sugars
Sugar Pyrophosphorylpolyprenols
Isoprenoid Phosphate Sugars

Compounds functioning as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. They include the polyisoprenyl pyrophosphates.


Toxoplasmosis, Ocular
Ocular Toxoplasmosis

Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.


Antiviral Drug Resistance
Drug Resistance, Viral

The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.


Implantable Contact Lens
Lens, Intraocular
Lenses, Intraocular

An intraocular lens permanently implanted behind the IRIS and in front of the natural EYE LENS.


Forward displacement of a superior vertebral body over the vertebral body below.


Sulfite Reductase (NADPH)
NADPH-Sulfite Reductase

A NADPH-dependent oxidase that reduces hydrogen sulfite to HYDROGEN SULFIDE. It is found in many microoganisms.


Tomography, Spiral Computed
CAT Scan, Spiral
Helical Computed Tomography
Computer-Assisted Tomography, Spiral
Spiral Computed Tomography
Computerized Tomography, Spiral
Computed Tomography, Spiral
Helical CT
Tomography, Helical Computed
Spiral CT
CT Scan, Spiral

Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.


A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.


A traditional practice, most notably in traditional medicine, which involves placing cups on the skin to create suction believed to help increase blood flow and promote healing associated with chronic neck and low back pain in the short term (From National Center for Complementary and Integrative Health, https://nccih.nih.gov/news/cupping (Accessed 11/5/2018)).


Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)


Nucleotide Transport Proteins
Nucleotide Translocase

Proteins involved in the transport of NUCLEOTIDES across cellular membranes.


beta Lactamase Inhibitors
beta Lactamase Antagonists
beta-Lactamase Inhibitors

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES.


Methyl Methanesulfonate
Dimethylsulfonate
Methylmethane Sulfonate
Mesilate, Methyl
Methylmesilate
Methyl Mesylate
Methyl Methylenesulfonate

An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA.


Biopsy, Chorionic Villi
Chorionic Villi Sampling
Chorionic Villus Sampling

A method for diagnosis of fetal diseases by sampling the cells of the placental chorionic villi for DNA analysis, presence of bacteria, concentration of metabolites, etc. The advantage over amniocentesis is that the procedure can be carried out in the first trimester.


Areas of land set aside to grow crops or raise LIVESTOCK.


Salts and esters of the 7-carbon saturated monocarboxylic acid heptanoic acid.


A developmental anomaly in which the lower sternum is posteriorly dislocated and concavely deformed, resulting in a funnel-shaped thorax.


Anti-Gay Bias
Homophobia
Anti-Homosexual Bias

Differential treatment or unequal access to opportunities or services based on perceived homosexual preference or orientation.


Professional Family Relationship
Professional-Family Relations

The interactions between the professional person and the family.


Clomipramine Hydrochloride
Anafranil
Clomipramine Maleate (1:1)
Hydiphen
Clomipramine
Chlomipramine
Clomipramine Monohydrochloride
Chlorimipramine

A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.


An old term that is no longer used in the scientific literature. Cholera morbus refers to acute GASTROENTERITIS occurring in summer or autumn; characterized by severe cramps, diarrhea, and vomiting.


Pregnancy, Hematologic Complications
Hematologic Pregnancy Complications
Pregnancy Complications, Hematological
Complications, Hematologic Pregnancy
Pregnancy Complications, Hematologic

The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.


A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.


A plant genus of the family ASTERACEAE. The common name of marigold is also used for CALENDULA.


Maxillofacial Surgeons
Exodontists
Oral Surgeons
Oral and Maxillofacial Surgeons

Dentists specializing in TOOTH EXTRACTION.


A phylum of radially symmetrical invertebrates characterized by possession of stinging cells called nematocysts. It includes the classes ANTHOZOA; CUBOZOA; HYDROZOA, and SCYPHOZOA. Members carry CNIDARIAN VENOMS.


Wart-Hog Disease Virus
African Swine Fever Virus

The lone species of the genus Asfivirus. It infects domestic and wild pigs, warthogs, and bushpigs. Disease is endemic in domestic swine in many African countries and Sardinia. Soft ticks of the genus Ornithodoros are also infected and act as vectors.


Sitagliptin Phosphate, Metformin Hydrochloride Drug Combination

Sitagliptin Phosphate Metformin Hydrochloride Drug Combination

Sitagliptin Phosphate-Metformin Hydrochloride Drug Combination

A pharmaceutical preparation of sitagliptin phosphate and metformin hydrochloride that is used in the treatment of TYPE 2 DIABETES.


Plasma Substitutes
Plasma Volume Expanders
Blood Expanders

Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.


Tyrosine Kinase-type Cell Surface Receptor HER3

A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.


Migratory Inhibitory Factor-Related Protein MRP

A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.


Infections, Adenoviridae
Adenoviridae Infections
Infections, Adenovirus
Adenovirus Infections

Virus diseases caused by the ADENOVIRIDAE.


Mammalian Diving Reflex
Reflex, Diving
Diving Reflex

BREATH HOLDING; VASOCONSTRICTION; and a drop in HEART RATE in response to submersion of the face in cold water.


Enzymes of a subclass of TRANSFERASES that catalyze the transfer of an amidino group from donor to acceptor. EC 2.1.4.


Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.


Mixed Salivary Gland Tumor
Adenoma, Pleomorphic
Syringoma, Chondroid
Salivary Gland Tumor, Mixed

A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)


Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.


Anaplastic Lymphoma Receptor Tyrosine Kinase

A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.


A cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not cyclical, but rather it is expressed in response to proliferative signals. Cyclin D may therefore play a role in cellular responses to mitogenic signals.


Uridine Diphosphate N Acetylmuramic Acid

Uridine Diphosphate N-Acetylmuramic Acid

A nucleoside diphosphate sugar which is formed from UDP-N-acetylglucosamine and phosphoenolpyruvate. It serves as the building block upon which peptidoglycan is formed.


Advertising
Telemarketing
Advertising as Topic
Advertisement as Topic

Works about the act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)


Dose Fractionation, Radiation
Radiation Dose Fractionation
Dose Fractionation, Radiotherapy
Radiotherapy Dose Fractionation

Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.


RNA, Ribosomal, Self-Splicing
Self-Splicing Ribosomal RNA

Components of ribosomal RNA that undergo auto-catalyzed molecular rearrangements of their RNA sequence.


tat Protein
Gene Product, tat
tat Gene Products
Gene Products, tat

Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.


Tumor Immune Evasion
Tumor Escape
Immune Escape, Tumor
Immune Evasion, Tumor

The ability of tumors to evade destruction by the IMMUNE SYSTEM. Theories concerning possible mechanisms by which this takes place involve both cellular immunity (IMMUNITY, CELLULAR) and humoral immunity (ANTIBODY FORMATION), and also costimulatory pathways related to CD28 ANTIGENS and B7-1 ANTIGEN.


The practice of nursing by licensed, non-registered persons qualified to provide routine care to the sick.


AI (Artificial Intelligence)
Machine Intelligence
Computer Vision Systems
Knowledge Representation (Computer)
Computational Intelligence
Knowledge Acquisition (Computer)
Computer Reasoning
Artificial Intelligence

Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.


Archaeon Archaea Archaeobacteria Archebacteria Archaebacteria

One of the three domains of life (the others being BACTERIA and Eukarya), formerly called Archaebacteria under the taxon Bacteria, but now considered separate and distinct. They are characterized by: (1) the presence of characteristic tRNAs and ribosomal RNAs; (2) the absence of peptidoglycan cell walls; (3) the presence of ether-linked lipids built from branched-chain subunits; and (4) their occurrence in unusual habitats. While archaea resemble bacteria in morphology and genomic organization, they resemble eukarya in their method of genomic replication. The domain contains at least four kingdoms: CRENARCHAEOTA; EURYARCHAEOTA; NANOARCHAEOTA; and KORARCHAEOTA.


Apolipoproteins and lipocalins that occur in HIGH-DENSITY LIPOPROTEINS. They bind or transport lipids in the blood including sphingosine-1-phosphate, MYRISTIC ACID; STEARIC ACIDS; and ALL-TRANS-RETINOIC ACID.


Purinergic P2 Receptor Antagonists
Purinergic P2 Receptor Blockers
P2 Purinoceptor Antagonists
P2 Purinoceptor Blockers

Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.


Fanconi Anemia Group C Complementing Protein

Fanconi Anemia Complementation Group C Protein

A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.


An order of small, wingless parasitic insects, commonly known as lice. The suborders include ANOPLURA (sucking lice); AMBLYCERA; ISCHNOCERA; and Rhynchophthirina (elephant and warthog lice).


The most abundant form of RNA. Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. Individual chains are conventionally designated by their sedimentation coefficients. In eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50% of the ribosome. (Dorland, 28th ed)


Dopaminergic Agonists
Receptor Agonists, Dopamine
Dopamine Agonists
Agonists, Dopamine Receptor
Dopamine Receptor Agonists
Dopamine Agonist
Dopamine Receptor Agonist
Dopaminergic Agonist
Agonists, Dopaminergic

Drugs that bind to and activate dopamine receptors.


Emergence Delirium
Anesthesia Emergence Delirium
Emergence Agitation
Postanesthetic Excitement
Emergence Excitement
Agitated Emergence

A form of DELIRIUM which occurs after GENERAL ANESTHESIA.


Marginalization, Social
Social Marginalization

Individuals or groups, excluded from participation in the economic, social, and political activities of membership in a community.


Protandry
Sex Determination Genetics
Sex Determination Genetic Processes
Sex Determination Process
Protogyny
Sex Determination Processes

Physiological mechanisms where by a female individual changes to a male during its normal life cycle course.


Matrix, Extracellular
Extracellular Matrix

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.


A single SELENOCYSTEINE containing protein that binds reduced GLUTATHIONE and can act as an antioxidant.


A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)


Proactive Inhibition
Inhibition, Proactive

The state or process hypothesized to account for poorer learning rate for elements later in a series as compared to the learning rate for elements coming earlier in a series.


Cytokine that stimulates the proliferation of T-LYMPHOCYTES and shares biological activities with IL-2. IL-15 also can induce proliferation and differentiation of B-LYMPHOCYTES.


Tentorium Cerebelli
Pachymeninx
Falx Cerebelli
Falx Cerebri
Dura Mater

The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.


Ganglion, Autonomic
Ganglia, Autonomic
Autonomic Ganglia

Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.


National Institute of Environmental Health Sciences (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to reduce the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual's health. It was established in 1969.


Alcian Blue 8GS
Alcian Blue
Alcian Blue 8GX

A copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.


T-Independent Antigens
Thymus-Independent Antigens
Antigens, T Independent
TI-2 Antigens
Antigens, T-Independent

Antigens which may directly stimulate B lymphocytes without the cooperation of T lymphocytes.


Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.


In ethics, the principle that requires avoiding the causation of harm.


Hospital Administrators
Hospital Administrator
Administrator, Hospital
Administrators, Hospital

Managerial personnel responsible for implementing policy and directing the activities of hospitals.


Cyclic N-oxide radical functioning as a spin label and radiation-sensitizing agent.


Water Pipe Smoking
Hookah Smoking
Waterpipe Smoking


Eukaryotic Initiation Factor 2alpha Kinase

Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase

Double Stranded RNA-Dependent Kinase (dsl)

A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.


The process by which a person or group of persons comes to be regarded or treated as lacking in human qualities.


Biased behaviors or attitudes, differential treatment, unequal access to social participation or opportunities based on age.


A condition characterized by mucosal tears at the ESOPHAGOGASTRIC JUNCTION, sometimes with HEMATEMESIS. Typically it is caused by forceful bouts of retching or VOMITING.


Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.


Protein-L-Arginine Iminohydrolases
Protein-Arginine Deiminase
Peptidylarginine Deiminase
Protein-Arginine Deiminases
Peptidylarginine Deiminases
Protein-L-Arginine Iminohydrolase

A family of ENZYMES that, in the presence of calcium ion, converts ARGININE to CITRULLINE in proteins. There are five PAD isotypes in mammals.  In humans: they include PAD1, 2, 3, 4 and 6. They are encoded by five paralogous genes named PADI and clustered on human chromosome 1.


Lymphedema And Yellow Nails
Yellow Nail Syndrome

A rare condition characterized by the presence of yellow nails, LYMPHEDEMA, and/or PLEURAL EFFUSION with respiratory tract involvement. Abnormal lymphatic network may play a role in its etiology. Occasionally inherited, yellow nail syndrome mostly is sporadic without apparent family history.


Polyadenylate Polymerase
Polyadenylate Synthetase
Poly A Polymerase
Polynucleotide Adenylyltransferase
ATP-RNA Adenylyltransferase

An enzyme that catalyzes the synthesis of polyadenylic acid from ATP. May be due to the action of RNA polymerase (EC 2.7.7.6) or polynucleotide adenylyltransferase (EC 2.7.7.19). EC 2.7.7.19.


Infestations with arthropods of the subclass ACARI, superorder Acariformes.


Chain Elongation, Peptide, Translational

A process of GENETIC TRANSLATION, when an amino acid is transferred from its cognate TRANSFER RNA to the lengthening chain of PEPTIDES.


Vagal Nerve Stimulation
Vagus Nerve Stimulation

An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.


A pattern recognition receptor that forms heterodimers with TOLL-LIKE RECEPTOR 2.


CD151 Antigen
Antigens, CD151
Tetraspanin 24
Antigen CD151

A tetraspanin protein that associates with LAMININ-binding INTEGRINS. It is essential for proper assembly of BASEMENT MEMBRANE in the KIDNEY GLOMERULUS and KIDNEY TUBULES and may play a role in the regulation of CELL MOTILITY.


An enzyme that catalyzes the METHYLATION of phosphatidyl-N-methylethanolamine to produce phosphatidyl-N-dimethylethanolamine. This enzyme can also methylate phosphatidyl-N-dimethylethanolamine to produce phosphatidyl-N-trimethylethanolamine (PHOSPHATIDYLCHOLINE).


Cleavage Stage, Ovum
Segmentation Stage, Ovum

The earliest developmental stage of a fertilized ovum (ZYGOTE) during which there are several mitotic divisions within the ZONA PELLUCIDA. Each cleavage or segmentation yields two BLASTOMERES of about half size of the parent cell. This cleavage stage generally covers the period up to 16-cell MORULA.


Guanosine Diphosphomannose
Guanosine Pyrophosphate Mannose
Guanosine Diphosphate Mannose
GDP Mannose

A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.


Finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds. (From Merck Index, 11th ed)


Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as "ox hunger".


Pivmecillinam
Pivmecillinam Hydrochloride
Mecillinam Pivaloyl Ester
Amdinocillin Pivoxil
Pivamdinocillin
Selexid
FL-1039

Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.


A plant genus of the family URTICACEAE which is the most common cause of pollinosis in Mediterranean countries. It is the source of 'allergen Par o I' and of Pollinex used for DESENSITIZATION, IMMUNOLOGIC.


Deoxyribonucleic acid that makes up the genetic material of plants.


o-Chlorobenzylidene malonotrile
ortho-Chlorobenzylidene Malonitrile
o-Chlorobenzylidene Malonitrile
CS Tear Gas
o-Chlorobenzylidenemalonitrile
ortho-Chlorobenzylidenemalonitrile
2-Chlorobenzylidenemalonitrile
2-Chlorobenzylidene Malonitrile

A riot control agent which causes temporary irritation of the eyes and the mucosal surface of the respiratory tract. It is a more potent irritant than OMEGA-CHLOROACETOPHENONE, but less incapacitating.


Skin Fillers
Dermal Fillers
Skin Filler
Dermal Filler

Materials such as COLLAGEN or HYALURONIC ACID that are injected or deposited into the DERMIS for the purpose of skin augmentation.


Parainfluenza Virus Infections
Parainfluenza
Paramyxoviridae Infections
Infections, Paramyxoviridae

Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.


Sulfuric Acid Esters
Organic Sulfates
Thiosulfuric Acid Esters
Sulfates, Organic


Cervical Plexus Block
Cervical Plexus Blockade
Cervical Plexus Anesthesia

A blocking of NEURAL CONDUCTION in the network of nerve fibers innervating the neck and shoulder.


Encephalomyelitis, Western Equine
Western Equine Encephalitis

A form of arboviral encephalitis (which primarily affects horses) endemic to western and central regions of NORTH AMERICA. The causative organism (ENCEPHALOMYELITIS VIRUS, WESTERN EQUINE) may be transferred to humans via the bite of mosquitoes (CULEX tarsalis and others). Clinical manifestations include headache and influenza-like symptoms followed by alterations in mentation, SEIZURES, and COMA. DEATH occurs in a minority of cases. Survivors may recover fully or be left with residual neurologic dysfunction, including PARKINSONISM, POSTENCEPHALITIC. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-9)


Meat-Packing Industry
Industry, Meat-Packing

The aggregate enterprise of technically producing packaged meat.


Photochemotherapy, Extracorporeal
Photopheresis
Extracorporeal Photochemotherapy
Extracorporeal Photopheresis

A process in which peripheral blood is exposed in an extracorporeal flow system to photoactivated 8-methoxypsoralen (METHOXSALEN) and ultraviolet light - a procedure known as PUVA THERAPY. Photopheresis is at present a standard therapy for advanced cutaneous T-cell lymphoma; it shows promise in the treatment of autoimmune diseases.


PARylation
PolyADPRibosylation
Poly(ADPRibosyl)ation
Poly ADP Ribosylation
Poly(ADP-Ribosyl)ation
Poly-ADPRibosylation
Poly-ADP-Ribosylation

Post-translational modification of proteins with POLY ADENOSINE DIPHOSPHATE RIBOSE.


a-Synucleinopathies
Synucleinopathies
alpha-Synucleinopathies
alpha Synuclein Pathology

Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.


Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.


Craniopharyngioma
Rathke Pouch Tumor
Rathke Cleft Neoplasm
Rathke's Cleft Neoplasm
Craniopharyngioma, Child
Craniopharyngioma, Adamantinous
Craniopharyngioma, Adult
Neoplasm, Rathke's Cleft
Craniopharyngioma, Papillary
Rathke's Pouch Tumor
Neoplasm, Rathke Cleft

A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)


Loss of the tooth substance by chemical or mechanical processes


Postpartum Abstinence
Virginity
Celibacy
Sexual Abstinence


A post-MORULA preimplantation mammalian embryo that develops from a 32-cell stage into a fluid-filled hollow ball of over a hundred cells. A blastocyst has two distinctive tissues. The outer layer of trophoblasts gives rise to extra-embryonic tissues. The inner cell mass gives rise to the embryonic disc and eventual embryo proper.


Inhibition, Reactive
Reactive Inhibition

Tendency toward a lessened strength of response due to practice or activity. It is independent of the effect of reward and is a direct function of time interval since the last response and the number of preceding responses.


Tuberculous Pericarditis
Pericarditis, Tuberculous

INFLAMMATION of the sac surrounding the heart (PERICARDIUM) due to MYCOBACTERIUM TUBERCULOSIS infection. Pericarditis can lead to swelling (PERICARDIAL EFFUSION), compression of the heart (CARDIAC TAMPONADE), and preventing normal beating of the heart.


Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.


Comb and Wattles
Wattles
Comb
Wattles and Comb

Fleshy and reddish outgrowth of skin tissue found on top of the head, attached to the sides of the head, and hanging from the mandible of birds such as turkeys and chickens.


Cofilin-2
CFL2 Protein
Muscle Cofilin
Cofilin 2
M-Cofilin

A member of the cofilin family of proteins that is expressed in MUSCLE CELLS. It has ACTIN depolymerization activity that is dependent on HYDROGEN-ION CONCENTRATION.


Arginyl T RNA Synthetase
Arginine-tRNA Ligase
Arg-tRNA Ligase
Arginyl-tRNA Synthetase

An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19.


Inhibitors, Guanine Nucleotide Dissociation

Guanine Nucleotide Dissociation Inhibitors

Protein factors that inhibit the dissociation of GDP from GTP-BINDING PROTEINS.


Metal-Organic Frameworks
Porous Coordination Networks
Porous Coordination Polymers
Covalent Organic Framework

Supramolecular networks that consist of ordered arrangements of organic electron donor linkers (usually ditopic or polytopic organic carboxylates) and metal cations. They can have an extremely high surface area and adjustable pore size that allows for the insertion of other molecules capable of various functions such as catalysis, capture of carbon dioxide, and drug delivery.


Voltage-Gated Sodium Channel beta Subunits

Voltage-gated sodium channel subunits that play a role in the assembly, expression, and functional modulation of the sodium channel. They form a heterotrimeric complex with the pore-forming sodium channel alpha subunits.


Sarcoma
Sarcoma, Spindle Cell
Sarcoma, Epithelioid
Sarcoma, Soft Tissue

A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.


Deficiency, Vitamin K
Vitamin K Deficiency

A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)


G-Protein Signaling Regulators
Regulating Factors, G-Protein
GTP-Binding Protein Regulators
G-Protein Regulating Factors
Regulators, G-Protein Signaling
Regulating Factors, GTP-Binding Protein

Proteins that regulate the signaling activity of GTP-BINDING PROTEINS. They are divided into three categories depending upon whether they stimulate GTPase activity (GTPASE-ACTIVATING PROTEINS), inhibit release of GDP; (GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS); or exchange GTP for GDP; (GUANINE NUCLEOTIDE EXCHANGE FACTORS).


Neisseria meningitidis, Serogroup W-135
Meningococcus, Serogroup W135
Meningococcus, Serogroup W-135
Neisseria meningitidis, Serogroup W135

Strains of Neisseria meningitidis found mostly in Africa.


Haemophilus paraphrophilus
Hemophilus paraphrophilus

A species of gram-negative bacteria in the genus HAEMOPHILUS, found in the normal flora of the human ORAL CAVITY and PHARYNX. It can cause SUBACUTE BACTERIAL ENDOCARDITIS; and BRAIN ABSCESS, among other conditions.


Sensitization, Immunological
Sensitization, Immunologic
Immunological Stimulation
Stimulation, Immunologic
Immunostimulation
Immunization
Variolation
Immunologic Sensitization
Immunologic Stimulation

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).


Early Intervention Education
Early Intervention, Educational
Head Start Program
Early Intervention, Education
Early Intervention (Education)

Procedures and programs that facilitate the development or skill acquisition in infants and young children who have disabilities, who are at risk for developing disabilities, or who are gifted. It includes programs that are designed to prevent handicapping conditions in infants and young children and family-centered programs designed to affect the functioning of infants and children with special needs. (From Journal of Early Intervention, Editorial, 1989, vol. 13, no. 1, p. 3; A Discursive Dictionary of Health Care, prepared for the U.S. House of Representatives Committee on Interstate and Foreign Commerce, 1976)


Dental Impression Material
Impression Materials, Dental
Material, Dental Impression
Materials, Dental Impression
Dental Impression Materials
Impression Material, Dental

Substances used to create an impression, or negative reproduction, of the teeth and dental arches. These materials include dental plasters and cements, metallic oxide pastes, silicone base materials, or elastomeric materials.


Navicular Bone of Hand
Os Scaphoideum
Scaphoid Bone
Os Naviculare Manus

The bone which is located most lateral in the proximal row of CARPAL BONES.


Linear Regression
Models, Linear
Linear Models
Log-Linear Models

Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.


Spinocranial Irradiation
Craniospinal Irradiation

A comprehensive radiation treatment of the entire CENTRAL NERVOUS SYSTEM.


Amino Acids, Essential
Essential Amino Acids

Amino acids that are not synthesized by the human body in amounts sufficient to carry out physiological functions. They are obtained from dietary foodstuffs.


Those nucleic acid sequences that function as units of heredity which are located within the CHLOROPLAST DNA.


Persons living in the United States of Mexican descent.


A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.


Decalcification Technique
Decalcification Technic

Removal of minerals from bones during bone examination.


CD122 Antigen
Interleukin-2 Receptor beta Chain
CD122 Antigens
Interleukin-15 Receptor beta Subunit
IL-2Rbeta2
Interleukin-2 Receptor beta
Antigens, CD122
IL-2-15 Receptor-beta
IL-2R BETA
Interleukin-2-15 Receptor-beta
Interleukin 2-15 Receptors-beta
Interleukin-2 Receptor beta Subunit
Interleukin-Binding Peptide p75
Interleukin-2, 15 Receptor beta Subunit

A receptor subunit that is a shared component of the INTERLEUKIN 2 RECEPTOR and the INTERLEUKIN-15 RECEPTOR. High affinity receptor complexes are formed with each of these receptors when their respective alpha subunits are combined with this beta subunit and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.


Chronic Necrotizing Pulmonary Aspergillosis

Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.


Commission on Professional and Hospital Activities

Commission on Professional, Hospital Activities

The non-profit, non-governmental organization which collects, processes, and distributes data on hospital use. Two programs of the Commission are the Professional Activity Study and the Medical Audit Program.


An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the purine de novo synthesis pathway. It requires the cofactor N(10)-FORMYLTETRAHYDROFOLATE as the formyl donor.


Height-Weight Ratio
Waist-Height Ratio
Waist to Height Ratio

The ratio of WAIST CIRCUMFERENCE to BODY HEIGHT.


Acetyl Carnitine
Medosan
Alcar
Branigen
Acetylcarnitine
Acetyl-L-Carnitine
Levocarnitine Acetyl
Acetylcarnitine, (R)-Isomer

An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.


Diphtheria
Corynebacterium diphtheriae Infection

A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.


Derivatives of TRYPTAMINES that are SEROTONIN RECEPTOR AGONISTS acting at 5-HT1 RECEPTORS. Some are used to treat MIGRAINE DISORDERS.


EAAT-2 Excitatory Amino Acid Transporter

A glutamate plasma membrane transporter protein found in ASTROCYTES and in the LIVER.


Assimilatory Reduced Nicotinamide Adenine Dinucleotide Phosphate-Nitrate Reductase

Assimilatory Nitrate Reductase, NADPH-Dependent

An enzyme that catalyzes the oxidation of nitrite to nitrate in the presence of NADP+. It is a FLAVOPROTEIN that contains IRON and MOLYBDENUM. This enzyme was formerly classified as EC 1.6.6.3 and should not be confused with the enzyme NITRATE REDUCTASE (NAD(P)H).


Actin Cytoskeleton
Actin Microfilaments
Microfilaments
Actin Filaments

Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.


Albinism affecting the eye in which pigment of the hair and skin is normal or only slightly diluted. The classic type is X-linked (Nettleship-Falls), but an autosomal recessive form also exists. Ocular abnormalities may include reduced pigmentation of the iris, nystagmus, photophobia, strabismus, and decreased visual acuity.


Somatotypes
Body Types
Body Build
Ectomorph
Mesomorph
Endomorph

Particular categories of body build, determined on the basis of certain physical characteristics. The three basic body types are ectomorph (thin physique), endomorph (rounded physique), and mesomorph (athletic physique).


A form of systemic mastocytosis (MASTOCYTOSIS, SYSTEMIC) characterized by the presence of large numbers of tissue MAST CELLS in the peripheral blood without skin lesions. It is a high-grade LEUKEMIA disease with bone marrow smear of >20% MAST CELLS, multi-organ failure and a short survival.


Imaging techniques that use illumination created with several optical interference filters by which the frequency ranges are spectrally narrowed and light scatter is greatly reduced. Thus the reflected photons reconstituting the images are from distinct depths (the surface and deeper layers) of the object being imaged.


Subclinical Infections
Asymptomatic Infections

Infections that do not exhibit symptoms.


ST Segment Elevation Myocardial Infarction

A clinical syndrome defined by MYOCARDIAL ISCHEMIA symptoms; persistent elevation in the ST segments of the ELECTROCARDIOGRAM; and release of BIOMARKERS of myocardial NECROSIS (e.g., elevated TROPONIN levels). ST segment elevation in the ECG is often used in determining the treatment protocol (see also NON-ST ELEVATION MYOCARDIAL INFARCTION).


11614 R.P.
Phanurane
Aldadiene
Canrenone
SC-9376

A synthetic pregnadiene compound with anti-aldosterone activity.


Savanna Baboons
Baboons, Savanna
Papio
Baboons

A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.


A plant genus of the family ASTERACEAE. Members contain bidensyneosides (polyacetylene glucosides).


Urishiol Oxidase
Laccase II
Laccase
Laccase B
Laccase I
p-Diphenol Oxidase
Laccase III

A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzosemiquinone. It also has activity towards a variety of O-quinols and P-quinols. It primarily found in FUNGI and is involved in LIGNIN degradation, pigment biosynthesis and detoxification of lignin-derived products.


Transplantation, Stem Cell
Stem Cell Transplantation

The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.


Central Nervous System Fungal Infections

Infections, Fungal, Central Nervous System

Fungal Infections, Central Nervous System

MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).


Progesterone, (13 alpha,17 alpha)-(+-)-Isomer

The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.


Rhinitis, Allergic, Nonseasonal
Rhinitis, Allergic, Perennial

Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.


Mucosal Disease, Bovine Viral Diarrhea
Bovine Virus Diarrhea-Mucosal Disease
Bovine Virus Diarrhea Mucosal Disease

Acute disease of cattle caused by the bovine viral diarrhea viruses (DIARRHEA VIRUSES, BOVINE VIRAL). Often mouth ulcerations are the only sign but fever, diarrhea, drop in milk yield, and loss of appetite are also seen. Severity of clinical disease varies and is strain dependent. Outbreaks are characterized by low morbidity and high mortality.


Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome

Autism, Dementia, Ataxia, and Loss of Purposeful Hand Use

An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)


Industrial Fungicides
Fungicides, Industrial

Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.


Glucose Dehydrogenases
Glucose Oxidoreductases

D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.47; EC 1.1.1.118; EC 1.1.1.119 and EC 1.1.99.10.


Urinary Antiinfective Agents
Anti-Infective Agents, Urinary
Antiseptics, Urinary
Antiinfective Agents, Urinary
Urinary Anti-Infective Agents

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.


Nucleus of the Optic Tract
Nucleus of the Pretectal Area
Olivary Pretectal Nucleus
Sublentiform Nucleus
Pretectum
Principal Pretectal Nucleus
Pretectal Region
Pretectal Area

Region of midbrain tectum located posterior to the THALAMUS and anterior to the SUPERIOR COLLICULUS.


Hepato-Pulmonary Syndrome
Hepatopulmonary Syndrome

A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).


Acid Ammonium Purpurate
Murexide
Ammonium Purpurate

5,5'-Nitrilodibarbituric acid ammonium derivative. Used as an indicator for complexometric titrations.


Glycine Carbonate (2:1), Monosodium Salt

Glycine Carbonate (2:1), Monopotassium Salt

Glycine Carbonate (2:1), Monolithium Salt

Glycine Carbonate (1:1), Monosodium Salt

A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.


Genomes of temperate BACTERIOPHAGES integrated into the DNA of their bacterial host cell. The prophages can be duplicated for many cell generations until some stimulus induces its activation and virulence.


Butyrate Response Factor 1
Early Response Factor Berg36

A ZINC FINGER MOTIF containing immediate early protein that is closely related to TRISTETRAPROLIN. It interacts with and helps destabilize VASCULAR ENDOTHELIAL GROWTH FACTOR mRNA.


Maternal Nutritional Physiological Phenomena

Maternal Nutritional Physiological Phenomenon

Nutrition of a mother which affects the health of the FETUS and INFANT as well as herself.


Gene Product, nef
nef Gene Products
3'-orf Protein
Gene Products, nef
nef Protein

Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.


A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.


A plant genus of the family ASTERACEAE. Many of the member species have been reclassified to other genera such as Machaeranthera, Isocoma, Ericameria, etc. Ingestion of the plant has been associated with MILK SICKNESS.


Kidney Circulation
Circulation, Renal
Circulation, Kidney
Renal Blood Flow
Renal Circulation

The circulation of the BLOOD through the vessels of the KIDNEY.


Urocanase
Urocanate Hydratase
Urocaninase

An enzyme that catalyzes the conversion of 4,5-dihydro-4-oxo-5-imidazolepropanoate to urocanate and water. EC 4.2.1.49.


Software Verification
Software Validation

The act of testing the software for compliance with a standard.


Gepharnate
Gefarnate
Geranyl Farnesylacetate
Ulco
Gefarnil

A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.


Degenerative Diseases, Central Nervous System

Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.


Dizene Dicarboxylic Acid Bis(N,N-dimethylamide)

A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.


A layer of acellular matrix that lies beneath the CORNEAL EPITHELIUM and above the CORNEAL STROMA. It consists of randomly arranged COLLAGEN fibers in a condensed bed of intercellular substance. It provides stability and strength to the cornea.


IRF-7 Transcription Factor
IRF-7C Transcription Factor
Interferon Regulatory Factor-7
IRF-7A Transcription Factor
IRF-7B Transcription Factor

An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES.


Myxoma, Nerve Sheath
Neurothecoma
Neurotheceoma
Neurothekeoma

A benign myxoma of cutaneous nerve sheath origin. Theke is from the Greek theke, sheath. (From Stedman, 25th ed)


A specialized proteolytic enzyme secreted by intestinal cells. It converts TRYPSINOGEN into its active form TRYPSIN by removing the N-terminal peptide. EC 3.4.21.9.


Devices used for SMOKING which convey SMOKE directly into the mouth.


Agents counteracting or neutralizing the action of POISONS.


Calbindin D(28)K
Calbindin D28K
Calbindin-D28K
Calbindin 1

A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. It is regulated in some tissues by VITAMIN D.


A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.


Oxidoreductases, NADH, NADPH
NADH, NADPH Oxidoreductases

A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.


Protein Mx
Protein Mx, Interferon-Induced
Myxovirus Resistance Proteins

Interferon-induced DYNAMIN-like GTP-binding proteins localized in the cytoplasm, nuclear pore complex and nucleus. They play a role in antiviral defense and immunity.


A plant genus of the family PRIMULACEAE that contains anagallosides, which are molluscacidal triterpenoid saponins.


Genes, Synthetic
Synthetic Genes
Artificial Genes

Biologically functional sequences of DNA chemically synthesized in vitro.


4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridinone. Analog of uridine lacking a ring-nitrogen in the 3-position. Functions as an antineoplastic agent.


Alveolar Proteinoses, Pulmonary
Alveolar Proteinosis, Pulmonary
Proteinoses, Pulmonary Alveolar
Pulmonary Alveolar Proteinoses
Proteinosis, Pulmonary Alveolar
Pulmonary Alveolar Proteinosis

A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.


A condition characterized by the presence of RHEUMATOID ARTHRITIS associated with a specific form of pneumoconiosis, often in coal miners and asbestos workers.


p-Chlorophenylalanine
para-Chlorophenylalanine
Fenclonin
DL-3-(4-Chlorophenyl)alanine
CP-10,188
Fenclonine (L)-Isomer
Fenclonine, (D)-Isomer
Fenclonine
Fenclonine Hydrobromide
Fenclonine Hydrochloride

A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.


A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.


Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.


Surgical incision on the FASCIA. It is used to decompress compartment pressure (e.g. in COMPARTMENT SYNDROMES; circumferential burns and extremity injuries) or to release contractures (e.g. in DUPUYTREN'S CONTRACTURE).


Mitral Valve Annuloplasty
Mitral Annuloplasty
Mitral Valve Annulus Repair

A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.


Hemorrhagic Diathesis
Hemorrhagic Disorders

Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).


Aurora B Kinases
Aurora-Related Kinase 2
Aurora Kinase B
Aurora Kinases B
Serine-Threonine Protein Kinase 12

An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS.


Dissertations, Academic as Topic
Theses as Topic
Academic Dissertations as Topic
Dissertation, Academic as Topic

Works about substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.


The genetic complement of an insect (INSECTS) as represented in its DNA.


Cardioauditory Syndrome of Jervell and Lange-Nielsen

Deafness, Congenital, and Functional Heart Disease

Prolonged QT Interval in EKG and Sudden Death

A form of long QT syndrome that is associated with congenital deafness. It is characterized by abnormal cardioelectrophysiology involving the VOLTAGE-GATED POTASSIUM CHANNEL. It results from mutation of KCNQ1 gene (Subtype 1 or JLN1) or the KCNE1 gene (Subtype 2 or JLN2).


Receptors, Nicotinic
Nicotinic Receptors
Nicotinic Receptor
Nicotinic Acetylcholine Receptor
Nicotinic Acetylcholine Receptors

One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.


Giant Cell Thyroiditis
Thyroiditis, Subacute
Subacute Nonsuppurative Thyroiditis
Subacute Painful Thyroiditis
De Quervain Thyroiditis
Granulomatous Thyroiditis

Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection.


FMRP Protein
Fragile X Mental Retardation Protein
Fragile X Mental Retardation-1 Protein

A RNA-binding protein that is found predominately in the CYTOPLASM. It helps regulate GENETIC TRANSLATION in NEURONS and is absent or under-expressed in FRAGILE X SYNDROME.


Intervertebral Disc Displacement
Slipped Disc
Prolapsed Disc
Disc, Herniated
Slipped Disk
Intervertebral Disk Displacement
Herniated Disk
Herniated Disc
Prolapsed Disk
Disk Prolapse
Disk, Herniated

An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region.


Solute Carrier Family 22 Member 2
OCT2 Protein
SLC22A2 Protein
Organic Cation Transporter 2

Organic cation transporter consisting of twelve transmembrane domains and expressed primarily in the kidney. It transports a wide range of metabolites, drugs, and neurotransmitters from the blood to the KIDNEY TUBULES, including DOPAMINE; SEROTONIN; CHOLINE; and CISPLATIN.


Immunogenicity, Vaccine
Antigenicity, Vaccine

The capacity of VACCINES to stimulate the ADAPTIVE IMMUNE RESPONSE to produce antibodies and antigen-specific T-CELL responses.


Pacing, Cardiac, Artificial
Cardiac Pacing, Artificial

Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.


The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.


HLA Class I Histocompatibility Antigen, B-27 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.


Scrotal Hydrocele
Testicular Hydrocele
Vaginal Hydrocele

Accumulation of serous fluid between the layers of membrane (tunica vaginalis) covering the TESTIS in the SCROTUM.


Alloisoleucine
L-Isoleucine
Isoleucine, L-Isomer
Isoleucine

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.


An enzyme that catalyses the reaction of D-glucosamine 6-phosphate with ACETYL-COA to form N-acetylglucosamine 6-phosphate.


Services, Urban Health
Urban Health Services
Health Services, Urban

Health services, public or private, in urban areas. The services include the promotion of health and the delivery of health care.


Respiratory Distress Syndrome, Acute
ARDS, Human
Shock Lung
Adult Respiratory Distress Syndrome
Respiratory Distress Syndrome, Adult
Acute Respiratory Distress Syndrome

A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.


Dithiazanine Iodide
Dizan
Dithiazanine
3,3'-Diethylthiadicarbocyanine
Cyanine Dye DiS-C2-(5)

3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium. A benzothiazole that was formerly used as an antinematodal agent and is currently used as a fluorescent dye.


Aflatoxin M1, cis(+-)-Isomer
Aflatoxin M1
Aflatoxin M
4-Hydroxyaflatoxin B1

A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).


Virtual Reality Immersion Therapy
Virtual Reality Exposure Therapy
Virtual Reality Therapy

Treatment technique in a virtual environment which allows the participant to experience a sense of presence in an immersive, computer-generated, three-dimensional, interactive environment that minimizes avoidance behavior and facilitates emotional involvement. (from Curr Psychiatry Rep (2010) 12:298)


Diazepam Binding Inhibitor
Endozepine
Acyl-CoA-Binding Protein
DBI Peptide
Medium-Chain Acyl CoA-Binding Protein
EpDBI

An 86-amino acid polypeptide, found in central and peripheral tissues, that displaces diazepam from the benzodiazepine recognition site on the gamma-aminobutyric acid receptor (RECEPTORS, GABA). It also binds medium- and long-chain acyl-CoA esters and serves as an acyl-CoA transporter. This peptide regulates lipid metabolism.


HMG1
Amphoterin
Heparin-Binding Protein p30
Box Protein 1, High Mobility Group
HMG 1 Protein
HMGB1 Protein
HMG-1 Protein
FM1 Gene Product
HMGB1

A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.


Infectious Canine Hepatitis
Canine Infectious Hepatitis
Hepatitis, Canine Infectious
Hepatitis, Infectious Canine

A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.


Subperiosteal Dental Implantation
Subperiosteal Implantation
Dental Implantation, Subperiosteal
Implantation, Subperiosteal Dental
Implantation, Subperiosteal

The grafting or inserting of an appliance designed to fit over the surface of the mandible or the maxilla, beneath the specialized connective tissue that covers the bone (periosteum).


Biological Availability
Physiologic Availability
Bioavailability
Availability, Biological
Biologic Availability
Availability, Physiologic
Availability Equivalency
Availability, Biologic

The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.


CYP24 Family
Cytochrome P450 Family 24
CYP24 Enzymes

A cytochrome P450 enzyme family that includes VITAMIN D3 24-HYDROXYLASE.


Blood Coagulation Factor
Coagulation Factor
Clotting Factors
Blood Coagulation Factors
Coagulation Factors, Blood
Coagulation Factors
Coagulation Factor, Blood
Factor, Coagulation
Factors, Coagulation

Endogenous substances, usually proteins, that are involved in the blood coagulation process.


Surgical Diagnostic Technic
Surgical Diagnostic Technics
Diagnostic Technic, Surgical
Surgical Diagnostic Technique
Surgical Diagnostic Techniques
Diagnostic Technics, Surgical
Technics, Surgical Diagnostic
Techniques, Surgical Diagnostic
Diagnostic Techniques, Surgical
Technique, Surgical Diagnostic
Diagnostic Technique, Surgical
Technic, Surgical Diagnostic

Methods and procedures for the diagnosis of disease or dysfunction by examination of the pathological site or operative field during surgical intervention.


Nonsuppressible Insulinlike Activity
NSILA-P
NSILA-S
NSILA
Nonsuppressible Insulin-Like Activity

A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.


IHNV
Infectious hematopoietic necrosis virus

The type species of NOVIRHABDOVIRUS, in the family RHABDOVIRIDAE. It is a major pathogen of TROUT and SALMON.


Synthetic Vitreous Fibers
Mineral Fibers
Mineral Fiber

Long, pliable, cohesive natural or manufactured filaments of various lengths. They form the structure of some minerals. The medical significance lies in their potential ability to cause various types of PNEUMOCONIOSIS (e.g., ASBESTOSIS) after occupational or environmental exposure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p708)


Chromosome 5 Short Arm Deletion Syndrome

Deletion of Short Arm of Chromosome 5 Syndrome

An infantile syndrome characterized by a cat-like cry, failure to thrive, microcephaly, MENTAL RETARDATION, spastic quadriparesis, micro- and retrognathia, glossoptosis, bilateral epicanthus, hypertelorism, and tiny external genitalia. It is caused by a deletion of the short arm of chromosome 5 (5p-).


Percutaneous Nephrostomy
Nephrostomy, Percutaneous

The insertion of a catheter through the skin and body wall into the kidney pelvis, mainly to provide urine drainage where the ureter is not functional. It is used also to remove or dissolve renal calculi and to diagnose ureteral obstruction.


Surgical Procedure, Pulmonary
Pulmonary Surgical Procedures
Pulmonary Surgical Procedure
Surgical Procedures, Pulmonary
Procedures, Pulmonary Surgical
Procedure, Pulmonary Surgical


Alteration of the immune system or of an immune response by agents that activate or suppress its function. This can include IMMUNIZATION or administration of immunomodulatory drugs. Immunomodulation can also encompass non-therapeutic alteration of the immune system effected by endogenous or exogenous substances.


Piribedil Hydrochloride
ET-495
Piribedil Mono-hydrochloride
Trivastal
Piribedil Mesylate
EU-4200
Piribedil
Piribendyl

A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist.


Public Reporting of Health Care Data
Public Reporting of Healthcare Data
Quality Data Reporting
Public Reporting of Quality Data
Mandated Quality Data Reporting

Required public availability of quality indicators data from health facilities.


Microbial Consortia
Microbial Consortium

Groups of microorganisms that share metabolic interdependence.


Nuclear Protein CBP
CREB-Binding Protein
Phospho-CREB-Binding Protein

A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.


Esteroproteases
Proteinases
Proteases
Peptide Hydrolases
Peptidases
Proteolytic Enzymes

Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.


Nyctereutes
Nyctereutes procyonoides
Raccoon Dogs

The lone species in the genus Nyctereutes, family CANIDAE. It is found in the woodland zone from southeastern Siberia to Vietnam and on the main islands of Japan.


Personnel, Educational
Educational Personnel

Professionals responsible for teaching in an institution or place of learning such as a school, college, vocational institute, or university.


Trigger Area
Trigger Point
Trigger Points

Discrete spots in taut bands of muscle that produce local and referred pain when muscle bands are compressed.


Contrast Sensitivity
Visual Contrast Sensitivity

The ability to detect sharp boundaries (stimuli) and to detect slight changes in luminance at regions without distinct contours. Psychophysical measurements of this visual function are used to evaluate visual acuity and to detect eye disease.


Proposed anesthetic with possible anticonvulsant and sedative properties.


Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation.


A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.


Karyopherin-beta
Kap95 protein
beta Karyopherins
Karyopherin-beta Subunit
p92 nuclear protein
Importin-beta
beta Importins
Karyopherin beta

Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.


Radiochemotherapy, Adjuvant
Adjuvant Chemoradiotherapy
Adjuvant Radiochemotherapy
Chemoradiotherapy, Adjuvant

Combined chemotherapy and radiotherapy given to augment some other form of treatment such as surgery. It is commonly used in the therapy of cancer.


Ribonucleic acid that makes up the genetic material of viruses.


55-kDa High-Affinity Calcium Binding Protein

A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.


Bacteroides melaninogenicus
Prevotella melaninogenica

A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium has been isolated from the mouth, urine, feces, and infections of the mouth, soft tissue, respiratory tract, urogenital tract, and intestinal tract. It is pathogenic, but usually in association with other kinds of organisms.


A plant genus of the family Lamiaceae. Inerminosides (iridoid glycosides); colebroside A; STEROIDS; STEROLS; terpenoid glucosides; and abietane DITERPENES have been found in this genus.


Pathological Conditions, Signs and Symptoms

Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome.


Klebsiella Infections
Infections, Klebsiella

Infections with bacteria of the genus KLEBSIELLA.


Cruciferae Moricandia Cress Brassicaceae

A plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida. They are mostly herbaceous plants with peppery-flavored leaves, due to gluconapin (GLUCOSINOLATES) and its hydrolysis product butenylisotrhiocyanate. The family includes many plants of economic importance that have been extensively altered and domesticated by humans. Flowers have 4 petals. Podlike fruits contain a number of seeds. Cress is a general term used for many in the Brassicacea family. Rockcress is usually ARABIS; Bittercress is usually CARDAMINE; Yellowcress is usually RORIPPA; Pennycress is usually THLASPI; Watercress refers to NASTURTIUM; or RORIPPA or TROPAEOLUM; Gardencress refers to LEPIDIUM; Indiancress refers to TROPAEOLUM.


Nocardia Infections
Nocardia asteroides Infection
Primary Cutaneous Nocardiosis
Cerebral Nocardiosis
Pulmonary Nocardiosis
Infections, Nocardia
Nocardiosis

Infections with bacteria of the genus NOCARDIA.


Mel(1a)-Melatonin Receptor
Melatonin MT1 Receptor
MT1 Receptor
Receptor, Melatonin, MT1

A melatonin receptor subtype that is primarily found in the HYPOTHALAMUS and in the KIDNEY.


p16INK4 Genes
Genes, p16INK4
p16 Genes
CDKN2 Genes
Genes, p16
MTS1 Genes
Genes, MTS1
Genes, CDKN2
Genes, p16INK4A
Genes, CDKN2A

Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.


Ileocecal Syndrome
Enterocolitis, Neutropenic
Neutropenic Enterocolitis

A syndrome characterized by inflammation in the ILEUM, the CECUM, and the ASCENDING COLON. It is observed in cancer patients with CHEMOTHERAPY-induced NEUTROPENIA or in other immunocompromised individuals (IMMUNOCOMPROMISED HOST).


Amyloid P Component
Serum Amyloid P-Component

Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE.


Thyroid Hormone Receptor Activator Molecule 1

A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.


Deoxyribonucleic acid that makes up the genetic material of fungi.