C 3 Nephritic Factor
C3 Nephritic Factor
Complement C3 Nephritic Factor
Complement 3 Nephritic Factor

An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.


Radioimmunoprecipitation Analysis
Radioimmunoprecipitation Assay
Farr Assay

Sensitive assay using radiolabeled ANTIGENS to detect specific ANTIBODIES in SERUM. The antigens are allowed to react with the serum and then precipitated using a special reagent such as PROTEIN A sepharose beads. The bound radiolabeled immunoprecipitate is then commonly analyzed by gel electrophoresis.


Cerebellar Golgi Cells
Golgi Cells of the Cerebellum

Inhibitory interneurons embedded in the granular layer of the CEREBELLAR CORTEX.


GSSG
Glutathione Disulfide
Glutathione, Oxidized
Glutathione Disulfide, Ion(1-)

A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.


Bordetella pertussis Infection, Respiratory

A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.


Deficiency, Ascorbic Acid
Ascorbic Acid Deficiency
Deficiency, Vitamin C
Vitamin C Deficiency

A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)


Book Illustration
Illustrated Books
Books, Illustrated

Designing a photograph, print, drawing, portrait, plate, diagram, facsimile, map, table, or other systematic representation of data in order to elucidate or decorate the contents of a publication.


MafK Transcription Factor
NF-E2 Transcription Factor, p18 Subunit
p18 NF-E2 Protein
MafK Protein

A small Maf protein involved in differentiation of ERYTHROID CELLS. MafK was originally described as the small subunit of the NF-E2 Transcription Factor, but other small MAF PROTEINS also serve as NF-E2 subunits.


Atraumatic Restorative Treatment, Dental

Treatment modality for DENTAL CARIES that uses manual excavation method and GLASS IONOMER CEMENTS. Because of its noninvasiveness and no need for expensive equipment and anesthesia it is promoted as an approach in places where dental care is not readily available.


BioMEMS
MEMS
Micro-Electro-Mechanical Systems
Micro-Electrical-Mechanical Systems

MEMS designed specifically to interact with biological samples.


Runt Disease
Graft vs Host Disease
Graft-vs-Host Disease
Homologous Wasting Disease
Graft-Versus-Host Disease

The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.


A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet-tasting compounds that are used as chemical intermediates and plant growth stimulants.


Antibody Fragments
Ig Fragments
Immunoglobulin Fragments

Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.


Phosphatase and Tensin Homologue on Chromosome Ten Protein

Mutated In Multiple Advanced Cancers 1 Protein

A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.


Human Immunodeficiency Virus-Associated Nephropathy

Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.


Midbrain Raphe Nuclei
Midbrain Raphe
Rostral Raphe Nuclei

Raphe nuclei located in the midbrain including the dorsal and median raphe nuclei. They are the origin of the major serotonergic innervation in the FOREBRAIN.


Hypothalamus, Middle
Intermediate Hypothalamic Region
Hypothalamus, Medial

Middle portion of the hypothalamus containing the arcuate, dorsomedial, ventromedial nuclei, the TUBER CINEREUM and the PITUITARY GLAND.


A genus of snakes of the family VIPERIDAE. It is distributed in West Pakistan, most of India, Burma, Ceylon, Thailand, southeast China, Taiwan, and a few islands of Indonesia. It hisses loudly when disturbed and strikes with great force and speed. Very prolific, it gives birth to 20-60 young. This viper is the leading cause of snakebite in India and Burma. (Moore: Poisonous Snakes of the World, 1980, p127)


Cyclic AMP-Dependent Protein Kinase Type II

Protein Kinase Type II, Cyclic AMP-Dependent

A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. They are tetrameric proteins that contain two catalytic subunits and two type II-specific regulatory subunits.


Receptors, CCR8
CC Chemokine Receptor 8
Antigens, CDw198
CDw198 Antigens
CCR8 Receptors

CCR receptors with specificity for CHEMOKINE CCL1. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and MACROPHAGES.


Patient Engagement
Patient Involvement
Patient Activation
Patient Empowerment
Patient Participation
Patient Participation Rates

Patient involvement in the decision-making process in matters pertaining to health.


Dystonia
Dystonia, Limb
Dystonia, Diurnal
Dystonia, Paroxysmal
Muscle Dystonia

An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)


Postnatal Depression
Post-Partum Depression
Depression, Postpartum
Post-Natal Depression
Postpartum Depression

Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)


Restoration Wear, Dental
Dental Restoration Wear
Denture Wear
Occlusal Wear, Restoration
Wear, Dental Restoration
Wear, Restoration Occlusal
Restoration Occlusal Wear

Occlusal wear of the surfaces of restorations and surface wear of dentures.


Helicobacter pylori
Campylobacter pylori

A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).


Theileriasis
East Coast Fever
Theileriosis
Corridor Disease

Infection of cattle, sheep, or goats with protozoa of the genus THEILERIA. This infection results in an acute or chronic febrile condition.


omega-CgTX GVIA
omega-Conus geographus toxin
omega-Conotoxin GVIA
omega-CgTX
Conus geographus Toxin
Conus geographus Toxin GVIA

A neurotoxic peptide, which is a cleavage product (VIa) of the omega-Conotoxin precursor protein contained in venom from the marine snail, CONUS geographus. It is an antagonist of CALCIUM CHANNELS, N-TYPE.


Surgical removal or artificial destruction of gonads.


Doubly unsaturated pregnane derivatives substituted with three hydroxy groups anywhere within the ring structure or side chains.


Calcimedin 35 alpha
Placental Anticoagulant Protein III
Annexin III
Annexin A3
Lipocortin III

A protein of the annexin family that catalyzes the conversion of 1-D-inositol 1,2-cyclic phosphate and water to 1-D-myo-inositol 1-phosphate.


Moloney Sarcoma Virus
Moloney murine sarcoma virus

A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) isolated from a rhabdomyosarcoma by Moloney in 1966.


A plant genus of the family ROSACEAE. Members contain TRITERPENES.


A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.


Microscopy, Fluorescence, Multiphoton
Multiphoton Excitation Microscopy
Multiphoton Fluorescence Microscopy
Fluorescence Microscopy, Multiphoton

Fluorescence microscopy utilizing multiple low-energy photons to produce the excitation event of the fluorophore (endogenous fluorescent molecules in living tissues or FLUORESCENT DYES). Multiphoton microscopes have a simplified optical path in the emission side due to the lack of an emission pinhole, which is necessary with normal confocal microscopes. Ultimately this allows spatial isolation of the excitation event, enabling deeper imaging into optically thick tissue, while restricting photobleaching and phototoxicity to the area being imaged.


Aldo-Keto Reductases
Aldo-Keto Reductase Superfamily
Aldo-Keto Reductase Family
Aldo-Keto Reductase

A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.


Sugar-rich liquid produced in plant glands called nectaries. It is either produced in flowers or other plant structures, providing a source of attraction for pollinating insects and animals, as well as being a nutrient source to animal mutualists which provide protection of plants against herbivores.


Aprocarb Baygon Sendran Propoxur O-Isopropoxyphenylmethylcarbamate Unden


Rats, Inbred BUF
Rats, BUF
Rats, Inbred Buffalo

An inbred strain of rat that is used for cancer research, particularly  the study of  CARCINOGENESIS


TRIM Proteins
RBCC Proteins
RBCC Protein Family
TRIM Protein Family
Tripartite Motif Proteins

A protein family defined by the presence of three ZINC FINGER domains, one of which is a RING FINGER DOMAIN, a coiled-coil region, and a highly variable C-terminal region. They function in many cellular processes including APOPTOSIS and CELL CYCLE regulation.


Variegate Porphyria
Protoporphyrinogen Oxidase Deficiency
Ppox Deficiency
Porphyria Variegate
Porphyria, Variegate
Porphyria Variegata

An autosomal dominant porphyria that is due to a deficiency of protoporphyrinogen oxidase (EC 1.3.3.4) in the LIVER, the seventh enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, COPROPORPHYRINS and protoporphyrinogen.


Kelsef
Zeefra Gé
Velosef
Cephradine, Non-Stoichiometric Hydrate
Nicef
SQ-11436
Dexef
Cefradine
Cephradine
Septacef
Cephradine Dihydrate
Velocef
Anspor
Sefril
Maxisporin

A semi-synthetic cephalosporin antibiotic.


Bcl-2-Interacting Mediator of Cell Death

A BCL-2-like protein that has a C-terminal BCL-2 homology (BH3) domain and forms heterodimers with other BCL-2 FAMILY PROTEINS. It is a strong inducer of APOPTOSIS and ANOIKIS; several isoforms are expressed (BimEL, Bim L, Bim-alpha, Bim-s; and Bim-gamma) that have different potencies for inducing apoptosis.


A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.


Tetrodotoxin
Tarichatoxin
Fugu Toxin
Tetradotoxin

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.


A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.


Hutchinson's Melanotic Freckle
Lentigo, Malignant
Lentigo Maligna
Freckle, Melanotic
Melanotic Freckle

A cellular subtype of malignant melanoma. It is a pigmented lesion composed of melanocytes occurring on sun-exposed skin, usually the face and neck. The melanocytes are commonly multinucleated with a "starburst" appearance. It is considered by many to be the in situ phase of lentigo maligna melanoma.


Asperger Disorder
Asperger Disease
Asperger's Disorder
Asperger's Syndrome
Asperger's Disease
Asperger Syndrome

A disorder beginning in childhood whose essential features are persistent impairment in reciprocal social communication and social interaction, and restricted, repetitive patterns of behavior, interests, or activities. These symptoms may limit or impair everyday functioning. (From DSM-5)


Clostridium botulinum type A
Clostridium botulinum A

Subtype of CLOSTRIDIUM BOTULINUM that produces BOTULINUM TOXINS, TYPE A which is neurotoxic to humans and animals.


9-cis-Retinoic Acid
Alitretinoin
9cRA Compound
Toctino
BAL4079
Panretin

A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.


Cocarboxylase
Thiamine Pyrophosphate
Berolase
Thiamine Diphosphate

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.


A reovirus infection, chiefly of sheep, characterized by a swollen blue tongue, catarrhal inflammation of upper respiratory and gastrointestinal tracts, and often by inflammation of sensitive laminae of the feet and coronet.


Procedures or techniques used to keep food from spoiling.


Nucleoporin
Nucleoporins
Nuclear Pore Complex Proteins

Proteins that form the structure of the NUCLEAR PORE. They are involved in active, facilitated and passive transport of molecules in and out of the CELL NUCLEUS.


Staphylococcal Infections, Skin
Skin Diseases, Staphylococcal
Staphylococcal Skin Diseases
Skin Infections, Staphylococcal
Staphylococcal Skin Infections
Infections, Staphylococcal Skin
Staphylococcal Diseases, Skin

Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.


Petrolatum
Paraffin Jelly
Petroleum Jelly
Petrolatum, Hydrophilic
Petrolatum, White
Vaseline

A colloidal system of semisolid hydrocarbons obtained from PETROLEUM. It is used as an ointment base, topical protectant, and lubricant.


The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS.


Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.


The use of music as an adjunctive therapy in the treatment of neurological, mental, or behavioral disorders.


ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.


A plant genus of the family ROSACEAE. Members contain sanguiin.


Abscess, Peritonsillar
Peritonsillar Abscess

An accumulation of purulent material in the area between the PALATINE TONSIL and its capsule.


Computed Tomography Angiography
Angiography, Computed Tomography
CT Angiography
Angiography, CT

A non-invasive method that uses a CT scanner for capturing images of blood vessels and tissues. A CONTRAST MATERIAL is injected, which helps produce detailed images that aid in diagnosing VASCULAR DISEASES.


Lipoprotein Lipase Activators
Lipoprotein Lipase Activating Agents

Compounds that increase the enzymatic activity of LIPOPROTEIN LIPASE. Lipoprotein lipase activators have a potential role in the treatment of OBESITY by increasing LIPID METABOLISM. Note that substances that increase the synthesis of lipoprotein lipase are not included here.


Medicine, Mongolian Traditional
Mongolian Medicine
Mongolian Folk Medicine

Medical practice indigenous to the peoples of Mongolia, developed over many years according to their culture, beliefs, and traditions.


Erwinia carotovora
Pectobacterium carotovorum

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that causes rotting, particularly of storage tissues, of a wide variety of plants and causes a vascular disease in CARROTS; and POTATO plants.


Cholestasis, Intrahepatic
Bile Duct Obstruction, Intrahepatic
Biliary Stasis, Intrahepatic
Intrahepatic Cholestasis

Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).


Infections, EBV
Herpesvirus 4 Infections, Human
Epstein-Barr Virus Infections
EBV Infections
Infections, Epstein-Barr Virus
Human Herpesvirus 4 Infections
Human Herpes Virus 4 Infections
Epstein-Barr Virus Infection

Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).


Vascular Endothelial Growth Factors
VEGFs

A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.


Subdural Cerebrospinal Fluid Effusion
Subdural Cerebrospinal Fluid Leakage
Subdural Effusion
Cerebrospinal Fluid Leakage, Subdural
Hygroma, Subdural
Cerebrospinal Fluid Effusion, Subdural

Leakage and accumulation of CEREBROSPINAL FLUID in the subdural space which may be associated with an infectious process; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; INTRACRANIAL HYPOTENSION; and other conditions.


Patient Credit and Collection
Patient Credit
Credit and Collection, Patient

Accounting procedures for determining credit status and methods of obtaining payment.


Vector Borne Diseases
Vectorborne Diseases
Vector-Borne Diseases

Infectious diseases transmitted by DISEASE VECTORS.


Dietary Cholesterol
Cholesterol, Dietary

Cholesterol present in food, especially in animal products.


Tumor Necrosis Factor Receptor Superfamily, Member 4

Receptors, Tumor Necrosis Factor, Member 4

A tumor necrosis family receptor with specificity for OX40 LIGAND. It is found on the surface of activated T-LYMPHOCYTES where it plays a role in enhancing cytokine production and proliferation of CD4-POSITIVE T-LYMPHOCYTES. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Body, Physical Appearance
Physical Appearance
Outward Appearance
Physical Appearance, Body

The superficial physical looks, characteristics or qualities of an individual as distinguished from the underlying unseen nature or attributes.


5-Androsten-3-beta-hydroxy-17-one
Prasterone
Dehydroisoandrosterone
Androstenolone
DHEA
5-Androsten-3-ol-17-one
Prasterone, 3 alpha-Isomer
Dehydroepiandrosterone

A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.


Rapamycin-Insensitive Companion of mTOR Protein

An adaptor protein subunit of MTORC2 COMPLEX. It functions as a structural component and is phosphorylated by RIBOSOMAL PROTEIN S6 KINASES, integrating signals for cell growth and proliferation, especially during embryonic development.


Cystatin A
Stefin A
Epidermal SH-Protease Inhibitor

A cytastin subtype found at high levels in the SKIN and in BLOOD CELLS. Cystatin A incorporates into the cornified cell envelope of stratified squamous epithelial cells and may play a role in bacteriostatic properties of skin.


The predominant milk-clotting enzyme from the true stomach or abomasum of the suckling calf. It is secreted as an inactive precursor called prorennin and converted in the acid environment of the stomach to the active enzyme. EC 3.4.23.4.


Arm Motif Proteins
Armadillo Domain Proteins
Armadillo Repeat Containing Proteins
Armadillo Motif Proteins
Armadillo Proteins
Armadillo Protein Family

A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION, regulation of DESMOSOME assembly, and CELL ADHESION.


Status Cataplexicus
Cataleptic Attacks
Cataplexy
Tonelessness Syndrome
Henneberg Syndrome

A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)


Cortical Depression, Spreading
Spreading Cortical Depression
Cortical Spreading Depression
Spreading Depression of Leao

The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)


Drosophila Son of Sevenless Protein
Son of Sevenless Protein, Drosophila
Drosophila SOS Protein
SOS Protein

A guanine nucleotide exchange factor from DROSOPHILA. Sevenless refers to genetic mutations in DROSOPHILA that cause loss of the R7 photoreceptor which is required to see UV light.


Thyroiditis, Infectious
Infectious Thyroiditis
Acute Suppurative Thyroiditis
Acute Infectious Thyroiditis
Thyroiditis, Suppurative

Acute inflammatory disease of the THYROID GLAND due to infections by BACTERIA; FUNGI; or other microorganisms. Symptoms include tender swelling, FEVER, and often with LEUKOCYTOSIS.


Compounds that form soothing films on the surface of MUCOUS MEMBRANES. They are generally used as agents to protect the integrity of internal EPITHELIUM.


Mannitol 2-Dehydrogenase
Mannitol Dehydrogenases
Mannitol Dehydrogenase
Mannitol Dehydrogenase (Cytochrome)

Catalyzes reaction: D-mannitol + ferricytochrome c <=> D-fructose + ferrocytochrome c


Nucleus Raphe Pallidus
Raphe Pallidus Nucleus

A nucleus in the medullary Raphe nuclei located rostral to the NUCLEUS RAPHE OBSCURUS and caudal to the NUCLEUS RAPHE MAGNUS.


Halobacterium salinarum
Halobacterium halobium

A species of halophilic archaea found in salt lakes. Some strains form a PURPLE MEMBRANE under anaerobic conditions.


Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.


Paraganglia, Nonchromaffin
Paraganglia, Non-Chromaffin

Several clusters of chemoreceptive and supporting cells associated with blood vessels and nerves (especially the glossopharyngeal and vagus). The nonchromaffin paraganglia sense pH, carbon dioxide, and oxygen concentrations in the blood and participate in respiratory, and perhaps circulatory, control. They include the CAROTID BODY; AORTIC BODIES; the GLOMUS JUGULARE; and the GLOMUS TYMPANICUM.


Potassium Voltage-Gated Channel, Subfamily H, Member 2

Ether-A-Go-Go-Related Potassium Channel 1

One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.


INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.


Innovation and improvement of the health care system by reappraisal, amendment of services, and removal of faults and abuses in providing and distributing health services to patients. It includes a re-alignment of health services and health insurance to maximum demographic elements (the unemployed, indigent, uninsured, elderly, inner cities, rural areas) with reference to coverage, hospitalization, pricing and cost containment, insurers' and employers' costs, pre-existing medical conditions, prescribed drugs, equipment, and services.


NRIP1 Protein
RIP140 Protein
Receptor Interacting Protein, 140 kDa
Nuclear Receptor-Interacting Protein 1
Nuclear Receptor Interacting Protein 1

A nuclear protein, characterized by multiple LXXLL motifs, that modulates activation of gene transcription by STEROID RECEPTORS, and transcriptional repression by NUCLEAR HORMONE RECEPTORS. It positively regulates gene expression of CIRCADIAN CLOCK PROTEINS AND PEPTIDES, including ARNTL TRANSCRIPTION FACTORS and CRYPTOCHROMES.


Intestinal Diseases, Parasitic
Parasitic Intestinal Diseases

Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.


Tryptophan Oxygenase
Tryptophan 2,3-Dioxygenase
Tryptophan Pyrrolase
TDO Dioxygenase

A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.


Caveolin-3
Caveolin 3
M-Caveolin
Muscle Caveolin

A caveolin that is expressed exclusively in MUSCLE CELLS and is sufficient to form CAVEOLAE in SARCOLEMMA. Mutations in caveolin 3 are associated with multiple muscle diseases including DISTAL MYOPATHY and LIMB-GIRDLE MUSCULAR DYSTROPHY.


Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.


Economic Model
Models, Economic
Model, Economic
Economic Models

Statistical models of the production, distribution, and consumption of goods and services, as well as of financial considerations. For the application of statistics to the testing and quantifying of economic theories MODELS, ECONOMETRIC is available.


Geologic Sediment
Sediments, Geologic
Sediments, Marine
Marine Oil Snow
Marine Snow
Sediment, Geologic
Geologic Sediments

A mass of organic or inorganic solid fragmented material, or the solid fragment itself, that comes from the weathering of rock and is carried by, suspended in, or dropped by air, water, or ice. It refers also to a mass that is accumulated by any other natural agent and that forms in layers on the earth's surface, such as sand, gravel, silt, mud, fill, or loess. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1689)


Traumatic Intracranial Hemorrhage
Intracranial Hematoma, Traumatic
Intracranial Hemorrhage, Traumatic
Hemorrhage, Intracranial, Traumatic

Bleeding within the SKULL induced by penetrating and nonpenetrating traumatic injuries, including hemorrhages into the tissues of CEREBRUM; BRAIN STEM; and CEREBELLUM; as well as into the epidural, subdural and subarachnoid spaces of the MENINGES.


Encephalopathy, Hyperbilirubinemic
Bilirubin Encephalopathy
Encephalopathy, Bilirubin
Hyperbilirubinemic Encephalopathy
Kernicterus

A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)


Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.


Small Inducible Cytokine B6
Chemokine alpha 3
Granulocyte Chemotactic Protein-2
CXCL6 Chemokine
Chemokine (C-X-C Motif) Ligand 6
Chemokine CXCL6

A CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS.


The simultaneous or sequential binding of multiple cell surface receptors to different ligands resulting in coordinated stimulation or suppression of signal transduction.


Proton-Coupled Folate Transporter
Solute Carrier Family 46, Member 1
Folate Transporter, Proton-Coupled

A symporter protein that couples the transport of FOLIC ACID with HYDROGEN IONS. The transporter functions most effectively under acidic conditions.


Poikiloderma Congenitale of Rothmund-Thomson

An autosomal recessive syndrome occurring principally in females, characterized by the presence of reticulated, atrophic, hyperpigmented, telangiectatic cutaneous plaques, often accompanied by juvenile cataracts, saddle nose, congenital bone defects, disturbances in the growth of HAIR; NAILS; and TEETH; and HYPOGONADISM.


Myelin-Oligodendrocyte Glycoprotein
MOG Glycoprotein

A transmembrane protein present in the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is one of the main autoantigens implicated in the pathogenesis of MULTIPLE SCLEROSIS.


Process, Psychotherapeutic
Psychiatric Therapeutic Process
Psychiatric Therapeutic Processes
Therapeutic Process, Psychiatric
Processes, Psychiatric Therapeutic
Psychotherapeutic Processes
Process, Psychiatric Therapeutic
Therapeutic Processes, Psychiatric
Processes, Psychotherapeutic

Experiential, attitudinal, emotional, or behavioral phenomena occurring during the course of treatment. They apply to the patient or therapist (i.e., nurse, doctor, etc.) individually or to their interaction. (American Psychological Association: Thesaurus of Psychological Index Terms, 1994)


Blepharospasm-Oromandibular Dystonia Syndrome, Idiopathic

Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome

A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108)


Branchiura (Crustacea)
Arguloida
Argulus
Fish Lice

Subclass of CRUSTACEA containing one order ARGULOIDA. They have sessile compound eyes and a shieldlike carapace.


A Disintegrin And Metalloproteinase with Thrombospondin Motifs 1 Protein

An ADAMTS protease that contains two disintegrin loops and three C-terminal thrombospondin (TS) motifs. It functions as an ANGIOGENESIS INHIBITOR as well as in normal tissue growth and fertility.


rap Protein, ras-Related
rap GTP-Binding Proteins
ras-Related rap Proteins

A family of MONOMERIC GTP-BINDING PROTEINS that are related to RAS PROTEINS.This enzyme was formerly listed as EC 3.6.1.47.


Judicial Bypass
Judicial Role
Judicial Consent
Judicial Action
Court Action

The kind of action or activity proper to the judiciary, particularly its responsibility for decision making.


Heart Rupture, Post-Infarction
Post-Infarction Heart Rupture
Cardiac Rupture, Post-Infarction

Laceration or tearing of cardiac tissues appearing after MYOCARDIAL INFARCTION.


Holy Basil
Ocimum tenuiflorum
Ocimum sanctum

A plant species of the genus OCIMUM, family LAMIACEAE that has been used in TRADITIONAL MEDICINE.


Glyoxalase I
Methylglyoxalase
Lactoylglutathione Lyase
Lactoyl Glutathione Lyase

An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.


Complement C3a
Complement 3a
C3a Complement
Complement Component 3a

The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.


Avian Paramyxoviruses
Avulavirus
Paramyxoviruses, Avian

A genus in the subfamily PARAMYXOVIRINAE, family PARAMYXOVIRIDAE, causing disease in domestic fowl. There are many species, the most well-known being avian paramyxovirus 1 (NEWCASTLE DISEASE VIRUS).


Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)

Glyceraldehyde 3-Phosphate Dehydrogenase, NADP

An NADP-dependent, non-phosphorylating aldehyde dehydrogenase that catalyzes the irreversible oxidation of GLYCERALDEHYDE 3-PHOSPHATE to 3-phosphoglycerate. It is found in the cytosol of a wide variety of organisms.


Lipid Regulating Drugs
Lipid Regulating Agents

Substances that alter the metabolism of LIPIDS.


Saccharum spontaneum
Saccharum
Sugarcane
Saccharum officinarum

A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.


CXC Chemokine Receptor
CXCR Receptors
Receptors, CXCR
CXC Chemokine Receptors

Chemokine receptors that are specific for CXC CHEMOKINES.


Lymphatic Cyst
Lymphocele
Lymphocoele
Cyst, Lymphatic

Cystic mass containing lymph from diseased lymphatic channels or following surgical trauma or other injury.


Transmitter Uptake Inhibitors, Neuronal
Neurotransmitter Uptake Inhibitors
Uptake Inhibitors, Neurotransmitter
Inhibitors, Neurotransmitter Uptake
Reuptake Inhibitors, Neurotransmitter

Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.


Entoptic Vision
Vision, Entoptic
Entoptic Phenomena
Entoptic Phenomenon

Visual sensation derived from sensory stimulation by objects or shadows inside the eye itself, such as floating vitreous fibers, tissues, or blood.


Synaptinemal Complex
Synaptonemal Complex

The three-part structure of ribbon-like proteinaceous material that serves to align and join the paired homologous CHROMOSOMES. It is formed during the ZYGOTENE STAGE of the first meiotic division. It is a prerequisite for CROSSING OVER.


Teniposide, (5a alpha,9 alpha(S*))-Isomer

Demethyl Epipodophyllotoxin Thenylidine Glucoside

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.


Son of Sevenless Homolog 1
SOS1 Protein
mSOS1 Protein

A mammalian homolog of the DROSOPHILA SON OF SEVENLESS PROTEIN. It is a guanine nucleotide exchange factor for RAS PROTEINS.


X Chromosome, Human
Chromosomes, Human, X

The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.


Information Systems, Ambulatory Care
Ambulatory Information Systems
Ambulatory Care Information Systems

Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of ambulatory care services and facilities.


Negative-Pressure Dressings
Negative-Pressure Wound Therapy
Topical Negative-Pressure Therapy
Vacuum-Assisted Closure

The application of a vacuum across the surface of a wound through a foam dressing cut to fit the wound. This removes wound exudates, reduces build-up of inflammatory mediators, and increases the flow of nutrients to the wound thus promoting healing.


A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.


Citrobacter rodentium
Citrobacter freundii Biotype 4280

A species of gram-negative bacteria in the genus CITROBACTER, family ENTEROBACTERIACEAE. As an important pathogen of laboratory mice, it serves as a model for investigating epithelial hyperproliferation and tumor promotion. It was previously considered a strain of CITROBACTER FREUNDII.


Ovarian Epithelial Carcinoma
Ovarian Cancer, Epithelial
Epithelial Ovarian Carcinoma
Carcinoma, Ovarian Epithelial
Ovarian Epithelial Cancer
Epithelial Ovarian Cancer

A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.


An inhibitor of anion conductance including band 3-mediated anion transport.


Epidemiologic Measurements
Measurements, Epidemiologic

Statistical calculations on the occurrence of disease or other health-related conditions in defined populations.


Management Teams, Institutional
Institutional Management Teams

Administrator-selected management groups who are responsible for making decisions pertaining to the provision of integrated direction for various institutional functions.


Transient Tachypnea of Newborn
Transient Tachypnea of the Newborn

Abnormal increase in RESPIRATORY RATE in the newborn. It is self-limiting and attributed to the delayed fetal lung fluid clearance often in CAESAREAN SECTION delivery.


Surgical incision or puncture into a URINARY BLADDER. Cystotomy may be used to remove URINARY CALCULI, or to perform tissue repair and reconstruction.


Occupational Therapy Department, Hospital

Occupational Therapy Departments, Hospital

Hospital Occupational Therapy Department

Hospital department responsible for the administration and provision of any occupational or work activity for remedial purposes.


Adenovirus E1A Protein Domain 3
Adenovirus E1A Proteins
Adenovirus E1A Protein

Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.


Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes

Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)


Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.


Transient Receptor Potential Channels, Type M

A subgroup of TRP cation channels named after melastatin protein. They have the TRP domain but lack ANKYRIN repeats. Enzyme domains in the C-terminus leads to them being called chanzymes.


Precision Medicine
P-Health
P Health
Personalized Medicine
Individualized Medicine

Clinical, therapeutic and diagnostic approaches to optimal disease management based on individual variations in a patient's genetic profile.


Hematoma, Epidural, Intracranial
Intracranial Epidural Hematoma
Epidural Hemorrhage, Cranial
Hemorrhage, Cranial Epidural
Extradural Hemorrhage, Cranial
Cranial Epidural Hematoma
Hematoma, Epidural, Cranial
Extradural Hematoma, Cranial

Accumulation of blood in the EPIDURAL SPACE between the SKULL and the DURA MATER, often as a result of bleeding from the MENINGEAL ARTERIES associated with a temporal or parietal bone fracture. Epidural hematoma tends to expand rapidly, compressing the dura and underlying brain. Clinical features may include HEADACHE; VOMITING; HEMIPARESIS; and impaired mental function.


Hemorrhages, Postoperative
Postoperative Hemorrhages
Postoperative Hemorrhage
Hemorrhage, Postoperative
Blood Loss, Postoperative

Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.


Patched-1 Receptor
Patched Homolog-1
Patched-1 Protein
Patched Receptor-1
PTCH1 Protein

A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.


A common, sensible, structured  and transparent approach to grading quality (or certainty) of evidence and strength of recommendations developed by the Grading of Recommendations Assessment, Development and Evaluation (short GRADE) working group.


Yeast, Budding
Saccharomycetales
Endomycetales
Endomycopsis
Budding Yeast

An order of fungi in the phylum Ascomycota that multiply by budding. They include the telomorphic ascomycetous yeasts which are found in a very wide range of habitats.


Leftose
Lysozyme
N-Acetylmuramide Glycanhydrolase
Muramidase

A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.


A plant genus of the family CUCURBITACEAE known for the fruit which is the source of the luffa sponge and the seeds which contain luffin.


Normal Volunteers
Healthy Subjects
Healthy Volunteers
Human Volunteers
Healthy Participants

Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from http://clinicalcenter.nih.gov/recruit/volunteers.html, accessed 2/14/2013)


Shrews, Tree
Treeshrews
Ptilocercus
Tupaiinae
Tree Shrews
Tupaiidae

The only family of the order SCANDENTIA, variously included in the order Insectivora or in the order Primates, and often in the order Microscelidea, consisting of five genera. They are TUPAIA, Ananthana (Indian tree shrew), Dendrogale (small smooth-tailed tree shrew), Urogale (Mindanao tree shrew), and Ptilocercus (pen-tailed tree shrew). The tree shrews inhabit the forest areas of eastern Asia from India and southwestern China to Borneo and the Philippines.


Bright Disease
Kidney Scarring
Glomerulonephritis

A historical classification which is no longer used. It described acute glomerulonephritis, acute nephritic syndrome, or acute nephritis. Named for Richard Bright.


A species of RUBULAVIRUS originally isolated from cultured primary monkey cells. Its natural host is the DOG in which it causes kennel cough, but it can also infect humans.


Mouse, 129
Mice, 129 Strain
Mice, Strain 129
129 Mice
129 Strain Mouse
129 Strain Mice
129 Mouse
Bar Harbor 129 Mice
Mice, 129
Bar Harbor 129 Mouse

Strains of mice arising from a parental inbred stock that was subsequently used to produce substrains of knockout and other mutant mice with targeted mutations.


alpha 1-Acid Glycoprotein (Acute Phase)
Acid Seromucoid
Seromucoid
Acid alpha 1-Glycoprotein
A(1)-Acid Seromucoid
alpha 1-Acid Glycoprotein
alpha 1-Glycoprotein Acid
Serum Sialomucin
Alpha(1)-Acid Glycoprotein
Orosomucoid
alpha 1-Acid Seromucoid


Bone Morphogenetic Protein Receptor Type II

Bone Morphogenetic Protein Receptors, Type II

A subtype of bone morphogenetic protein receptors with low affinity for BONE MORPHOGENETIC PROTEINS. They are constitutively active PROTEIN-SERINE-THREONINE KINASES that can interact with and phosphorylate TYPE I BONE MORPHOGENETIC PROTEIN RECEPTORS.


A plant genus of the family RANUNCULACEAE that contains aquiledine, isoaquiledine and cycloartane-type glycosides.


Endoscopes for visual examination of the rectum and anus.


Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.


Narghiles
Hookas
Sheeshas
Smoking Water Pipes
Hookahs
Shishas
Smoking Waterpipes

Pipes for smoking tobacco, cannabis, and other substances, in which smoke is drawn through water. Do not confuse with SMOKING PIPES.


Ethinyl Estradiol, (8 alpha,9 beta,13 alpha,14 beta)-Isomer

Ethinyl Estradiol, (9 beta,17 alpha)-Isomer

Ethinyl Estradiol, (8 alpha,17 alpha)-Isomer

A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.


Canine Influenza Virus, H3N8 Subtype
Influenza Virus, Equine, H3N8 Subtype
Equine Influenza Virus, H3N8 Subtype
H3N8 Virus
Influenza Virus, Canine, H3N8 Subtype
Influenza A Virus, H3N8 Subtype

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 8. The H3N8 subtype has frequently been found in horses.


The discharge of substances from the blood supply into the milk formed in and secreted by the MAMMARY GLAND.


Tissue Conditioning (Dental)
Dental Tissue Conditioning
Conditioning, Dental Tissue
Tissue Conditioning, Dental

The use of a treatment material (tissue conditioner) to re-establish tone and health to irritated oral soft tissue, usually applied to the edentulous alveolar ridge.


A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.


Urinary Reflex Incontinence
Urinary Incontinence, Urge
Urge Incontinence
Urinary Urge Incontinence

Involuntary discharge of URINE that is associated with an abrupt and strong desire to void. It is usually related to the involuntary contractions of the detrusor muscle of the bladder (detrusor hyperreflexia or detrusor instability).


Complement 6
C6 Complement
Complement C6
Complement Component 6

A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9. It is a polypeptide chain cross-linked by 32 disulfide bonds. C6 is the next complement component to bind to the membrane-bound COMPLEMENT C5B in the assembly of MEMBRANE ATTACK COMPLEX. It is encoded by gene C6.


Skeletal Muscle Myosins
Myosins, Skeletal Muscle

Myosin type II isoforms found in skeletal muscle.


Postdural Puncture Headache
Post-Dural Puncture Headache
Post-Lumbar Puncture Headache

A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.


A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM.  It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME.


Amevive
LFA-3 IgG(1) Fusion Protein
Alefacept
LFA-3 IgG1 Fusion Protein

A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. It is used in the management of moderate to severe chronic plaque PSORIASIS.


Calcium Release-Activated Calcium Channel Protein 1

ORAI Calcium Release-Activated Calcium Modulator 1

The pore-forming subunit of calcium release activated calcium channels. It is activated by STROMAL INTERACTION MOLECULE 1 upon intracellular calcium depletion.


Antibodies, Protozoan
Protozoan Antibodies

Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.


Receptors, N-Methylaspartate
NMDA Receptors
N-Methyl-D-Aspartate Receptors
Receptors, N-Methyl-D-Aspartate
N-Methylaspartate Receptors
NMDA Receptor-Ionophore Complex
Receptors, NMDA

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.


Elderly, Frail
Functionally-Impaired Elderly
Frail Elders
Frail Older Adults
Frail Elderly

Older adults or aged individuals who are lacking in general strength and are unusually susceptible to disease or to other infirmity.


A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of  thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.


Asparagine Synthetase
Asparagine Synthetase B
Aspartate-Ammonia Ligase
Asparagine Synthase

An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP. EC 6.3.1.1.


Spinal Autonomic Dysreflexia
Autonomic Dysreflexia
Dysreflexia, Autonomic
Hyperreflexia, Autonomic
Autonomic Hyperreflexia

A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)


The circulation in a portion of the body of one individual of blood supplied from another individual.


Ethchlorvinol Ethchlorvynol Placidyl Ethchlorovynol

A sedative and hypnotic that has been used in the short-term management of INSOMNIA. Its use has been superseded by other drugs.


Analgesics, Non-Narcotic
Nonopioid Analgesics
Non-Opioid Analgesics
Analgesics, Nonopioid
Analgesics, Nonnarcotic

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.


Mucopolysaccharidosis with excessive CHONDROITIN SULFATE B in urine, characterized by dwarfism and deafness. It is caused by a deficiency of N-ACETYLGALACTOSAMINE-4-SULFATASE (arylsulfatase B).


Receptor beta, Estrogen
Estrogen Receptors beta
Estrogen Receptor beta
ERbeta
Estrogen Receptor 2
ERbetacx

One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.


Polydactyly Polydactylia Polydactylism Hyperdactyly

A congenital anomaly of the hand or foot, marked by the presence of supernumerary digits.


Copper Intrauterine Devices
Copper-Releasing IUDs
IUD, Copper Releasing
Intrauterine Devices, Copper

Intrauterine contraceptive devices that depend on the release of metallic copper.


The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins.


Round-shaped structure usually located in the upper fundus of the UTERUS in early pregnancy. It comprises EMBRYO; AMNIOTIC FLUID; and YOLK SAC. It is visible in PRENATAL ULTRASONOGRAPHY by the fifth week of pregnancy. Its size is often used to determine and monitor GESTATIONAL AGE; FETAL GROWTH; and PREGNANCY COMPLICATIONS.


NatF N-Terminal Acetyltransferase
N-Terminal Acetyltransferase F
N-Terminal Acetyltransferase Type F

An N-terminal acetyltransferase subtype that consists of the Naa60p catalytic subunit. It is found in higher eukayotes and displays a substrate specificity for the N-terminal METHIONINE of peptides where the next amino acid in the chain is either LEUCINE; LYSINE; PHENYALANINE; ISOLEUCINE; or TRYPTOPHANE.


Infections, Respirovirus
Respirovirus Infections

Infections with viruses of the genus RESPIROVIRUS, family PARAMYXOVIRIDAE. Host cell infection occurs by adsorption, via HEMAGGLUTININ, to the cell surface.


SCA10 Protein
Atxn-10 Protein
ATXN10 Protein
Spinocerebellar Ataxia 10 Protein
Ataxin-10

An ataxin that is associated with the survival of cerebellar neurons. Expansion of the ATTCT pentanucleotide in the ATXN10 coding region is associated with SPINOCEREBELLAR ATAXIA 10.


Osteogenic Protein-1
Bone Morphogenetic Protein 7
BMP-7

A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.


Sense of Touch
Tactile Sense
Taction
Touch

Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.


Simulium
Simuliidae
Blackflies
Black Flies

A family of insects in the order DIPTERA, which include black flies, buffalo gnats and simulies. Several species are intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.


Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.


Cold Sore
Fever Blister
Herpes Labialis
Herpes Simplex, Labial

Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)


Fluorescent Antibody Technique, Indirect

Immunofluorescence Antibody Test, Indirect

A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)


The principles of proper professional conduct concerning the rights and duties of nurses themselves, their patients, and their fellow practitioners, as well as their actions in the care of patients and in relations with their families.


Barrett Syndrome
Barrett's Syndrome
Barrett Esophagus
Barrett Epithelium
Esophagus, Barrett
Barrett's Esophagus
Barrett Metaplasia

A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.


A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.


Swine Vesicular Exanthema Virus
VESV
San Miguel Sea Lion Viruses
Vesicular exanthema of swine virus

Multiple serotypes in the species VESICULAR EXANTHEMA OF SWINE VIRUS isolated from sea lions and seals. It is characterized by the formation of vesicles on the flippers which can cause ulcers.


California Virus
California Encephalitis Virus
Encephalitis Viruses, California
California Encephalitis Viruses
La Crosse Encephalitis Virus
Jamestown Canyon virus
Tahyna virus
California Group Viruses
Encephalitis Virus, California

A species in the ORTHOBUNYAVIRUS genus of the family BUNYAVIRIDAE. Serotypes are found in temperate and arctic regions and each is closely associated with a single species of vector mosquito. The vertebrate hosts are usually small mammals but several serotypes infect humans.


Extroversion, Psychology
Extraversion, Psychological
Extroversion, Psychological
Extraversion, Psychology
Extroversion
Extraversion
Extroversion (Psychology)
Extraversion (Psychology)

A state in which attention is largely directed outward from the self.


Corneal Damage
Corneal Scar
Corneal Injuries
Corneal Trauma
Cornea Injuries
Corneal Abrasions

Damage or trauma inflicted to the CORNEA by external means.


An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.


Rhinosporidium seeberi
Hyphochytrium
Rhinosporidium

A genus in the order Dermocystidium, class MESOMYCETOZOEA. It causes RHINOSPORIDIOSIS in MAMMALS and BIRDS.


Inventories, Hospital
Hospital Inventories
Inventory, Hospital
Hospital Inventory

Materials and equipment in stock; includes drugs in pharmacies, blood in blood banks, etc.


Order of dicotyledonous flowering plants consisting of 16 families, 112 genera, and nearly 2,500 species.


Life Style Induced Illness
Lifestyle
Life Style

Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)


Pectinidae Chlamys Patinopecten Scallops

A large family of mollusks in the class BIVALVIA, known commonly as scallops. They possess flat, almost circular shells and are found in all seas from shallow water to great depths.


Leukemia, Myeloid, Philadelphia Negative

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

A myelodysplastic/myeloproliferative disorder characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to CHRONIC MYELOID LEUKEMIA, but cytogenetically lacking a PHILADELPHIA CHROMOSOME or bcr/abl fusion gene (GENES, ABL).


An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.


Ethyl Chloride
Chloroethane
Cloretilo Chemirosa
WariActiv
Chloraethyl Dr. Henning
Gebauer's Ethyl Chloride

A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine.


Solanum nigrum
Black Nightshade
Nightshade, Black

A plant species of the genus SOLANUM, family SOLANACEAE that contains steroidal glycosides.


PepT1 Protein
SLC15A1 Protein
Peptide Transporter 1
Solute Carrier Family 15 Member 1
Pept-1 Transporter
Hydrogen-Peptide Cotransporter PepT1
hPEPT1 (Cotransporter)
Intestinal H+-Peptide Cotransporter

A proton-coupled symporter that transports OLIGOPEPTIDES and DIPEPTIDES. It localizes to the brush-border membrane of the INTESTINAL EPITHELIUM and plays a critical role in the assimilation of dietary proteins.


The application of methods designed to reduce the risk of harm associated with certain behaviors without reduction in frequency of those behaviors. The risk-associated behaviors include ongoing and active addictive behaviors.


Stenosing Tenosynovitis, De Quervain
De Quervain Stenosing Tenosynovitis
De Quervain Disease
De Quervain's Disease

Stenosing tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons in the first dorsal wrist compartment. The presenting symptoms are usually pain and tenderness at the radial styloid. The cause is almost always related to OVERUSE INJURY or is associated with RHEUMATOID ARTHRITIS.


Amino Acids, Branched Chain
Amino Acids, Branched-Chain

Amino acids which have a branched carbon chain.


Nephroblastoma Overexpressed Gene Product

A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.


An order of ascomycetous FUNGI which includes many economically important plant parasites as well as saprophytes.


The practice of medicine as applied to special circumstances associated with military operations.


Maltose-Binding Proteins
Maltose-Binding Protein

Periplasmic proteins that bind MALTOSE and maltodextrin. They take part in the maltose transport system of BACTERIA.


Juvenile Hereditary Epithelial Dystrophy

Corneal Dystrophy, Juvenile Epithelial of Meesmann

An autosomal dominant form of hereditary corneal dystrophy due to a defect in cornea-specific KERATIN formation. Mutations in the genes that encode KERATIN-3 and KERATIN-12 have been linked to this disorder.


Desensitization, Psychologic
Desensitization (Psychology)
Psychological Desensitization
Psychologic Desensitization
Desensitization, Psychological

A behavior therapy technique in which deep muscle relaxation is used to inhibit the effects of graded anxiety-evoking stimuli.


Varivax
Varicella Vaccine
Chickenpox Vaccine
Oka Varicella Vaccine

A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years.


Plasminogen Activator Inhibitor 2
PAI-2
Type 2 Plasminogen Activator Inhibitor
Serpin B2

Member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.


Dyspnea
Shortness of Breath
Breathlessness


Stem Cells, Mouse Embryonic
mESCs
Mouse Embryonic Stem Cells
Mouse Embryonic Stem Cell
Cells, Mouse Embryonic Stem

PLURIPOTENT STEM CELLS derived from the BLASTOCYST INNER CELL MASS of day 3.5 mouse embryos.


Cysteine Loop Ligand-Gated Ion Channel Receptors

A subfamily of ligand-gated ion channel receptors that share a characteristic loop which is formed by a disulfide bond between two CYSTEINE residues. These receptors typically contain five subunits with the cysteine-loop occurring near an N-terminal extracellular domain.


Prolonged Pregnancy
Pregnancy, Prolonged

A term used to describe pregnancies that exceed the upper limit of a normal gestational period. In humans, a prolonged pregnancy is defined as one that extends beyond 42 weeks (294 days) after the first day of the last menstrual period (MENSTRUATION), or birth with gestational age of 41 weeks or more.


Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.


Intestinal Hormone Receptor
Receptors, Intestinal Hormone
Receptors, Gastrointestinal Hormones
Receptors, Gastrointestinal Peptides
Intestinal Hormone Receptors
Receptors, Gastrointestinal Hormone
Gastrointestinal Hormone Receptors
Gastrointestinal Hormone Receptor

Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behavior of cells. Most gastrointestinal hormones also act as neurotransmitters so these receptors are also present in the central and peripheral nervous systems.


Capillary Leak Syndrome
Clinical Capillary Leak Syndrome
Systemic Capillary Leak Syndrome
Clarkson Disease

A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.


Patellofemoral Pain Syndrome
Anterior Knee Pain Syndrome
Patellofemoral Syndrome

A syndrome characterized by retropatellar or peripatellar PAIN resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) CHONDROMALACIA PATELLAE, the latter describing a pathological condition of the CARTILAGE and not a syndrome.


Rowson-Parr Virus
Friend Virus
Friend murine leukemia virus

A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.


Sulfentanil
Sufenta
Sufentanil Curasan
Sufentanil Citrate
Sufentanil-Ratiopharm
Sulfentanyl
Sufentanil
Sufentanil-Hameln
R-30730

An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.


Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)

A widely distributed cell surface transmembrane glycoprotein characterized by extracellular IMMUNOGLOBULIN DOMAINS. It stimulates the synthesis of MATRIX METALLOPROTEINASES and is found at high levels on the surface of malignant NEOPLASMS where it may play a role as a mediator of malignant cell behavior.


A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.


Nephritis, Lupus
Lupus Nephritis
Glomerulonephritis, Lupus
Lupus Glomerulonephritis

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).


Emboli Protection Devices
Embolic Protection Filters
Embolism Protection Devices
Embolic Protection Devices

Vascular filters or occlusive devices that provide mechanical protection of the distal end organ from blood clots or EMBOLISM-causing debri dislodged during ENDOVASCULAR PROCEDURES.


Flies of the species Musca domestica (family MUSCIDAE), which infest human habitations throughout the world and often act as carriers of pathogenic organisms.


Qinghao
Artemisia annua
Sweet Wormwood
Qing Hao
Sweet Annie

A plant species of the genus ARTEMISIA, family ASTERACEAE. It is the source of the antimalarial artemisinin (ANTIMALARIALS).


Small Ribosome Subunits
Small Ribosomal Subunits
Ribosome Subunits, Small
Ribosomal Subunits, Small

The small ribonucleoprotein component of RIBOSOMES. It contains the MESSENGER RNA binding site and two TRANSFER RNA binding sites - one for the incoming AMINO ACYL TRNA (A site) and the other (P site) for the peptidyl tRNA carrying the elongating peptide chain.


Excision of the prepuce of the penis (FORESKIN) or part of it.


Large-Conductance Calcium-Activated Potassium Channel beta Subunits

Large-Conductance Calcium-Activated Potassium Channels, beta Subunits

The regulatory subunits of large-conductance calcium-activated potassium channels.


Low-Density Lipoprotein-Related Protein-Associated Protein 1

LDL-Receptor Related Protein-Associated Protein

A membrane protein found in the rough endoplasm reticulum (ENDOPLASMIC RETICULUM, ROUGH) that binds to LDL-RECEPTOR RELATED PROTEINS. It may function to prevent ligand binding of receptors during protein processing events within endosomal compartments.


A form of therapy consisting in the local or general use of cold. The selective destruction of tissue by extreme cold or freezing is CRYOSURGERY. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


EGF Family of Proteins
Epidermal Growth Factors
EGF Receptor Ligands
Epidermal Growth Factor-Like Proteins

A family of proteins that are related to epidermal growth factor. They share in common a consensus sequence consisting of six spatially conserved CYSTEINE residues which form three intramolecular bonds. This consensus sequence is commonly referred to EGF motif and is considered essential for binding of the proteins to ERB RECEPTORS.


Keratin, Type 1
Type I Keratin
Keratins, Acidic
Keratins, Type I
Keratins, Type 1
Type I Intermediate Filament Proteins

A keratin subtype that includes keratins that are generally smaller and more acidic that TYPE II KERATINS. Type I keratins combine with type II keratins to form keratin filaments.


Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.


The 21-acetate derivative of desoxycorticosterone.


HHR6 Protein
Ubiquitin-Conjugating Enzymes
Ubiquitin-Conjugating Enzyme E2

A class of enzymes that form a thioester bond to UBIQUITIN with the assistance of UBIQUITIN-ACTIVATING ENZYMES. They transfer ubiquitin to the LYSINE of a substrate protein with the assistance of UBIQUITIN-PROTEIN LIGASES.


Anomalous Pancreaticobiliary Ductal Union

A group of anatomical variations in which the COMMON BILE DUCT and MAIN PANCREATIC DUCT are joined outside the duodenal wall often with abnormally long common channel rather than at the SPHINCTER OF ODDI.


Nervous System Lysosomal Enzyme Disorders

Nervous System Lysosomal Storage Diseases

Lysosomal Storage Diseases, Nervous System

Lysosomal Enzyme Disorders, Nervous System

A group of enzymatic disorders affecting the nervous system and to a variable degree the skeletal system, lymphoreticular system, and other organs. The conditions are marked by an abnormal accumulation of catabolic material within lysosomes.


Complex and Mixed Neoplasms
Neoplasms, Complex and Mixed

Neoplasms composed of more than one type of neoplastic tissue.


Nematoda Phasmidia Sipunculida Secernentea

A phylum of unsegmented helminths with fundamental bilateral symmetry and secondary triradiate symmetry of the oral and esophageal structures. Many species are parasites.


Common name for the species Perca fluviatilis.


pol Protein
Gene Products, pol
pol Polyproteins
pol Polyprotein
Gene Product, pol
pol Gene Products

Retroviral proteins coded by the pol gene. They are usually synthesized as a protein precursor (POLYPROTEINS) and later cleaved into final products that include reverse transcriptase, endonuclease/integrase, and viral protease. Sometimes they are synthesized as a gag-pol fusion protein (FUSION PROTEINS, GAG-POL). pol is short for polymerase, the enzyme class of reverse transcriptase.


Eicosatetraenoic acids substituted in any position by one or more hydroxy groups. They are important intermediates in a series of biosynthetic processes leading from arachidonic acid to a number of biologically active compounds such as prostaglandins, thromboxanes, and leukotrienes.


Saimiri
Monkey, Squirrel
Squirrel Monkey

A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.


Posterior Horn Cells
Dorsal Horn Neurons
Neurons, Dorsal Horn
Neurons, Posterior Horn
Dorsal Horn Cells

Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.


Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome

A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc5, along with Apc4, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.


CYP6 Enzymes
CYP6 Family
Cytochrome P450 Family 6

A cytochrome P450 enzyme family that occurs in insects. Its members function in the metabolism of XENOBIOTICS.


Building Industry
Construction Industry
Building Trades
Construction Trades

The aggregate business enterprise of building.


An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.


Virus, St. Louis Encephalitis
Viruses, St. Louis Encephalitis
St. Louis Encephalitis Viruses
Saint Louis Encephalitis Virus
Encephalitis Virus, St. Louis
Encephalitis Viruses, St. Louis
St. Louis encephalitis virus

A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiologic agent of ST. LOUIS ENCEPHALITIS in the United States, the Caribbean, and Central and South America.


Src Homology 2 Domain-Containing, Transforming Protein 1

SHC (Src Homology 2 Domain-Containing) Transforming Protein 1

SHC1 (Src Homology 2 Domain-Containing) Protein

Src Homology 2 Domain-Containing-Transforming Protein C1

An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of  ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.


Prepaid Health Plans
Health Plans, Prepaid

Contracts between an insurer and a subscriber or a group of subscribers whereby a specified set of health benefits is provided in return for a periodic premium.


Heterotrophic Growth
Heterotrophic Process
Heterotrophy
Heterotrophic Processes

The processes by which organisms utilize organic substances as their nutrient sources. Contrasts with AUTOTROPHIC PROCESSES which make use of simple inorganic substances as the nutrient supply source. Heterotrophs can be either chemoheterotrophs (or chemoorganotrophs) which also require organic substances such as glucose for their primary metabolic energy requirements, or photoheterotrophs (or photoorganotrophs) which derive their primary energy requirements from light. Depending on environmental conditions some organisms can switch between different nutritional modes (AUTOTROPHY; heterotrophy; chemotrophy; or PHOTOTROPHY) to utilize different sources to meet their nutrients and energy requirements.


Blood Circulation Time
Time, Blood Circulation
Circulation Time, Blood

Determination of the shortest time interval between the injection of a substance in the vein and its arrival at some distant site in sufficient concentration to produce a recognizable end result. It represents approximately the inverse of the average velocity of blood flow between two points.


Hydrocarbons, Acyclic
Acyclic Hydrocarbons

Organic compounds composed exclusively of carbon and hydrogen where no carbon atoms join to form a ring structure.


A plant genus of the family CLUSIACEAE. It is the source of the mangosteen fruit.


Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.


Child, Gifted
Adolescent, Gifted
Gifted Child
Children, Gifted

A child or adolescent who, when compared to others of the same age or experience, exhibits capability of high performance in intellectual, creative, or artistic areas, possesses an unusual capacity for leadership or excels in specific academic fields. (From PL 100-297, Sec. 4103, Definitions)


Common name for an order (Anguilliformes) of voracious, elongate, snakelike teleost fishes.


A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein

An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.


Dihydropteroate Synthetase
Dihydropteroate Synthase
Dihydropteroate Pyrophosphorylase

An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.


Nicotinamide
3-Pyridinecarboxamide
Enduramide
Vitamin PP
Papulex
Nicotinsäureamid Jenapharm
Nicobion
Vitamin B 3
Niacinamide
Vitamin B3

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.


Deuteromycota
Hyphomycetes
Mitosporic Fungi
Fungi, Mitosporic
Deuteromycetes
Fungi imperfecti

A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.


FL-1060
Penicillin Hx
Amdinocillin
Mecillinam

An amidinopenicillanic acid derivative with broad spectrum antibacterial action.


Patient Escort Service
Service, Patient Escort
Escort Service, Patient

A special service provided by volunteers to accompany patients who need help in moving about the health facility.


A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.


Total Shoulder Replacement
Arthroplasty, Replacement, Shoulder
Shoulder Replacement Arthroplasty


The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.


Betaine-Aldehyde Dehydrogenase
Betaine Aldehyde Oxidase
Glycine Betaine Aldehyde Dehydrogenase
Betaine Aldehyde Dehydrogenase

An NAD+ dependent enzyme that catalyzes the oxidation of betain aldehyde to BETAINE.


The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.


Cumulus Cells
Granulosa Cells, Cumulus
Cumulus Granulosa Cells

The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. At OVULATION they are extruded with OVUM.


Radiation Dosimeters
Radiation Dosimeter
Dosimeters

Devices that measure exposure to IONIZING RADIATION.


Cocultivation
Coculture
Coculture Techniques
Co-culture

A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.


Parasitic Worms
Nematomorpha
Worms, Parasitic
Helminths
Gordius
Aschelminthes

Commonly known as parasitic worms, this group includes the ACANTHOCEPHALA; NEMATODA; and PLATYHELMINTHS. Some authors consider certain species of LEECHES that can become temporarily parasitic as helminths.


PC6 Protein
Prohormone Convertase PC-6
PC6 Endoprotease
Prohormone Convertase, PC5
PC5 Proprotein Convertase
PC5B Preprotein Convertase
SPC6
PC5 Protein
Proprotein Convertase 5
PC6A Proprotein Convertase
PC5A Proprotein Convertase
Endoprotease PC6
Prohormone Convertase PC5
Prohormone Convertase-6

A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN, pro-membrane type-1 matrix metalloproteinase, and NEURAL CELL ADHESION MOLECULE L1.


Chickungunya Fever
Chikungunya Virus Infection
Chikungunya Fever

An acute infection caused by a mosquito-borne alphavirus CHIKUNGUNYA VIRUS characterized by RASH; FEVER; JOINT PAINS; CONJUNCTIVITIS; MENINGOENCEPHALITIS; LYMPHOPENIA; and THROMBOCYTOPENIA.


Apolipoprotein E-epsilon3
ApoE3
APOE-epsilon 3
Apo E3
Apo E-3
Apolipoprotein E3
APOE-epsilon3
Isoapolipoprotein E3
Apolipoprotein E-3

A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.


Vasoactive Intestinal Peptide Receptor 2

Pituitary Adenylate Cyclase-Activating Peptide Receptor Type III

Vasoactive Intestinal Peptide 2 Receptor

Receptors, Pituitary Adenylate Cyclase-Activating Peptide, Type III

Receptors, Vasoactive Intestinal Peptide, Type II

Vasoactive Intestinal Peptide Receptors, Type II

A pituitary adenylate cyclase-activating peptide receptor subtype found in LYMPHOCYTES. It binds both PACAP and VASOACTIVE INTESTINAL PEPTIDE and regulates immune responses.


EMIT Assay
Enzyme Multiplied Immunoassay Technique

An immunoenzyme test for the presence of drugs and other substances in urine and blood. The test uses enzyme linked antibodies that react only with the particular drug for which the sample is being tested.


Poly C
Cytosine Polynucleotides
Polycytidylic Acids

A group of cytosine ribonucleotides in which the phosphate residues of each cytosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.


Gonyaulax
Peridinium
Dinoflagellates
Gymnodinium
Dinoflagellida
Gambierdiscus toxicus

Species that causes CIGUATERA POISONING in humans.


Luteovirus
Beet Western Yellows Virus
Barley Yellow Dwarf Viruses

A genus of plant viruses that infects both monocotyledonous and dicotyledonous plants. Its organisms are persistently transmitted by aphids, and weeds may provide reservoirs of infection.


DTMP
Thymidine Monophosphate
Thymidylic Acids
Thymidylic Acid
Deoxythymidylate
TMP

5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.


A genus of beetles which infests grain products. Its larva is called mealworm.


Biomechanical Phenomena
Mechanobiological Phenomena
Biomechanic Phenomena
Kinematics

The mechanisms and processes by which mechanical forces elicit molecular response and regulate cell form and function.


GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups.


Leukemia, Hairy Cell
Hairy Cell Leukemia
Leukemic Reticuloendotheliosis
Reticuloendotheliosis, Leukemic

A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.


A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.


Sulfanilic Acids
Anilinesulfonic Acids
Aminobenzenesulfonic Acids

Aminobenzenesulfonic acids. Organic acids that are used in the manufacture of dyes and organic chemicals and as reagents.


A sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine.


Gingival Exudate
Gingival Crevicular Fluid

A fluid occurring in minute amounts in the gingival crevice, believed by some authorities to be an inflammatory exudate and by others to cleanse material from the crevice, containing sticky plasma proteins which improve adhesions of the epithelial attachment, have antimicrobial properties, and exert antibody activity. (From Jablonski, Illustrated Dictionary of Dentistry, 1982)


Scintiphotography
Scanning, Radioisotope
Gamma Camera Imaging
Radionuclide Imaging
Radioisotope Scanning
Scintigraphy

The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.


Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)


Cell Dedifferentiation
Dedifferentiation, Cell

A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE.


Vasopressin Defective Diabetes Insipidus

Diabetes Insipidus Secondary To Vasopressin Deficiency

Diabetes Insipidus, Neurohypophyseal Type

A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).


Silent Mating Type Information Regulator 2-like Proteins

A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.


Hereditary Coagulation Disorders
Coagulation Disorders, Inherited
Inherited Coagulation Disorders
Blood Coagulation Disorders, Inherited
Hereditary Blood Coagulation Disorders
Inherited Blood Coagulation Disorders

Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.


Research into the cause, transmission, amelioration, elimination, or enhancement of inherited disorders and traits.


A voltage-gated sodium channel activator.


Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4

A widely distributed purinergic P2X receptor subtype that plays a role in pain sensation. P2X4 receptors found on MICROGLIA cells may also play a role in the mediation of allodynia-related NEUROPATHIC PAIN.


A systemic non-venereal infection of the tropics caused by TREPONEMA PALLIDUM subspecies pertenue.


A plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.


Sequestrations, Bronchopulmonary
Sequestration, Pulmonary
Sequestrations, Pulmonary
Bronchopulmonary Sequestration
Sequestration, Bronchopulmonary
Pulmonary Sequestrations
Bronchopulmonary Sequestrations
Pulmonary Sequestration

A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.


A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.


Raynaud Disease
Raynaud Phenomenon
Cold Fingers, Hereditary
Raynaud's Disease

An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.


Myristoylated Alanine-Rich C Kinase Substrate

A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.


A family of gram-negative, gliding bacteria in the order Cytophagales, class Cytophagia. They are found in SOIL and SEA WATER.


An approach to ethics that focuses on theories of the importance of general principles such as respect for autonomy, beneficence/nonmaleficence, and justice.


Research Errors
Experimental Error
Scientific Mistakes
Scientific Errors
Experimental Mistakes
Scientific Experimental Error


Any observable response or action of a child from 24 months through 12 years of age. For neonates or children younger than 24 months, INFANT BEHAVIOR is available.


Schools, Dental
Dental School
Dental Schools
School, Dental

Educational institutions for individuals specializing in the field of dentistry.


A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)


Cytopathic Effect, Viral
Cytopathogenic Effect, Viral
Viral Cytopathogenic Effect

Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.


Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)


HLA Class I Histocompatibility Antigen, B-35 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*35 allele family.


Street Drug Testing
Drug Abuse Detection
Street Drug Detection
Substance Abuse Detection
Drug Abuse Testing
Drug Abuse Screening
Illicit Drug Testing
Substance Abuse Testing
Illicit Drug Detection

Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.


One of the PPAR nuclear transcription factors.


Tumor Necrosis Factor Receptor Superfamily, Member 3

A member of the tumor necrosis factor receptor superfamily. It has specificity for LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14. The receptor plays a role in regulating lymphoid ORGANOGENESIS and the differentiation of certain subsets of NATURAL KILLER T-CELLS. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Gynecologic Surgical Procedures
Procedures, Gynecologic Surgical
Surgical Procedure, Gynecologic
Gynecological Surgical Procedure
Gynecologic Surgery
Procedure, Gynecologic Surgical
Surgical Procedures, Gynecologic
Gynecologic Surgical Procedure
Surgery, Gynecological

Surgery performed on the female genitalia.


Environmental Monitoring
Environmental Surveillance
Monitoring, Environmental

The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.


Gram Positive Asporogenous Rods, Irregular

Gram-Positive Asporogenous Rods, Irregular

A group of irregular rod-shaped bacteria that stain gram-positive and do not produce endospores.


United States Health Insurance Portability and Accountability Act

Public Law 104-91 enacted in 1996, was designed to improve the efficiency and effectiveness of the healthcare system, protect health insurance coverage for workers and their families, and to protect individual personal health information.


Skin Window Technic
Skin Window Technique
Rebuck Skin Window Technique

A technique to study CELL MIGRATION in the INFLAMMATION process or during immune reactions. After an area on the skin is abraded, the movement of cells in the area is followed via microscopic observation of the exudate through a coverslip or tissue culture chamber placed over the area.


Impact Seizure
Epilepsy, Post-Traumatic
Concussive Convulsion
Epilepsy, Traumatic
Early Post-Traumatic Seizures
Late Post-Traumatic Seizures
Seizure Disorder, Post-Traumatic
Post-Traumatic Seizure Disorder

Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)


A genus of the pea family (Fabaceae), native from Europe to Central Asia and used in TRADITIONAL MEDICINE.


Cat Plague
Panleukopenia, Feline
Feline Panleukopenia
Feline Ataxia
Agranulocytosis, Feline
Feline Infectious Enteritis
Show Fever
Distemper, Feline
Ataxia, Feline

A highly contagious DNA virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. It is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. It is caused by FELINE PANLEUKOPENIA VIRUS or the closely related MINK ENTERITIS VIRUS or CANINE PARVOVIRUS.


Planets, Minor
Minor Planets
Planetoids
Plutoids
Asteroids

Small solar system planetary bodies including asteroids. Most asteroids are found within the gap lying between the orbits of Mars and Jupiter.


Process by which living organisms produce MINERALS that accumulate into hardened tissues (e.g., bones, teeth and shells), and cellular nanostructures that sequester away into macromolecules. Biosynthesized minerals include CALCIUM CARBONATE; FLUOROAPATITE; HYDROXYAPATITE; and MAGNETITE.


A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.


Tooth Socket
Alveolus Dentalis
Dental Alveolus

A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.


Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.


Propylamine Transferase
Spermidine Synthetase
Spermidine Synthase
Aminopropyltransferase
Putrescine Aminopropyltransferase

An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthiopropylamine)sulfonium adenosine to putrescine in the biosynthesis of spermidine. The enzyme has a molecular weight of approximately 73,000 kDa and is composed of two subunits of equal size.


Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.