Manipulation, Orthopedic
Orthopedic Manipulation

The planned and carefully managed manual movement of the musculoskeletal system, extremities, and spine to produce increased motion. The term is sometimes used to denote a precise sequence of movements of a joint to determine the presence of disease or to reduce a dislocation. In the case of fractures, orthopedic manipulation can produce better position and alignment of the fracture. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p264)


Atheroembolism
Cholesterol Embolism
Embolism, Cholesterol

Blocking of a blood vessel by CHOLESTEROL-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.


Operating Room Tables
Operation Tables
Operating Tables

A raised flat surface on which a patient is placed during surgical procedures.


Ticks, Relapsing Fever
Ornithodoros
Relapsing Fever Ticks

A genus of softbacked TICKS, in the family ARGASIDAE, serving as the vector of BORRELIA, causing RELAPSING FEVER, and of the AFRICAN SWINE FEVER VIRUS.


Telefax
Facsimile Transceiver
Telefacsimile
Facsimile Transmission
Fax

A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.


Phosphorylase b Kinase
Glycogen Phosphorylase Kinase
Phosphorylase Kinase

An enzyme that catalyzes the conversion of ATP and PHOSPHORYLASE B to ADP and PHOSPHORYLASE A.


A plant genus of the family POACEAE that contains the Phl p 4 allergen.


Child Neglect
Child Abuse
Child Maltreatment
Child Mistreatment

Abuse of children in a family, institutional, or other setting. (APA, Thesaurus of Psychological Index Terms, 1994)


Amphipathic Cationic Antimicrobial Peptides

Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.


Genes, Adenomatous Polyposis Coli
Genes, APC

Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.


Defective Interfering Particles
Incomplete Viruses
Defective Interfering Viruses
Defective Hybrids
Defective Viruses

Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.


Hypotension, Controlled
Controlled Hypotension
Hypotension, Induced
Induced Hypotension

Procedure in which arterial blood pressure is intentionally reduced in order to control blood loss during surgery. This procedure is performed either pharmacologically or by pre-surgical removal of blood.


The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.


A genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes.


A vine (Uncaria tomentosa) indigenous to the Amazon rainforest whose name is derived from its hook-like thorns. It contains oxindole alkaloids and glycosides and has many medicinal uses.


Receptors, Imidazoline-Guanidinium
Imidazoline-Guanidinium Receptors
Imidazoline Receptors

Receptors of CLONIDINE and other IMIDAZOLINES. Activity of the ligands was earlier attributed to ADRENERGIC ALPHA-2 RECEPTORS. Endogenous ligands include AGMATINE, imidazoleacetic acid ribotide, and harman.


Inflammation of the loose connective tissues around the ORBIT, bony structure around the eyeball. It is characterized by PAIN; EDEMA of the CONJUNCTIVA; swelling of the EYELIDS; EXOPHTHALMOS; limited eye movement; and loss of vision.


Nasal Disorders
Nose Diseases
Nasal Diseases

Disorders of the nose, general or unspecified.


Substance K Receptors
NK-2 Receptor
Neurokinin-2 Receptor
SP-K Receptor
Neurokinin A Receptors
NK-2 Receptor Site
Neurokinin-2 Receptors
Receptors, NK-2
Substance K Receptor
NK-2 Receptors
SP-K Receptors
Receptors, Substance K
Receptors, Neurokinin-2

A class of cell surface receptors for tachykinins that prefers neurokinin A; (NKA, substance K, neurokinin alpha, neuromedin L), neuropeptide K; (NPK); or neuropeptide gamma over other tachykinins. Neurokinin-2 (NK-2) receptors have been cloned and are similar to other G-protein coupled receptors.


Cancer-Associated Fibroblasts
Cancer Associated Fibroblasts
Tumor-Associated Fibroblasts

Subpopulation of heterogeneous fibroblasts within the TUMOR MICROENVIRONMENT that support NEOPLASTIC CELL TRANSFORMATION and NEOPLASTIC PROCESSES.


KvLQT Potassium Channels
KCNQ Potassium Channels

A family of delayed rectifier voltage-gated potassium channels that share homology with their founding member, KCNQ1 PROTEIN. KCNQ potassium channels have been implicated in a variety of diseases including LONG QT SYNDROME; DEAFNESS; and EPILEPSY.


Chromosomes, Human, Pair 19
Chromosome 19

A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.


Visceral Nervous System
Vegetative Nervous System
Autonomic Nervous System

The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.


Bombesin Dihydrochloride
Bombesin 14
Bombesin

A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.


Circulation, Cerebrovascular
Cerebrovascular Circulation
Cerebral Circulation
Cerebral Perfusion Pressure
Cerebral Blood Flow

The circulation of blood through the BLOOD VESSELS of the BRAIN.


Macroporous hydrogels that are produced at subzero temperatures. Cryogels have pores that are produced by growing ice crystals and have been developed with a tissue-like elasticity that is suitable for cell immunization experiments.


Chlorgyline Clorgilin Clorgyline Clorgiline

An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.


Type 4 Secretion System
Bacterial Secretion System, Type IV
Type 4 Secretion Systems
T4SS Secretion System
Type IV Secretion Systems
Bacterial Secretion Systems, Type IV
Type IV Secretion System

Multiprotein complexes that transport single proteins, multiprotein complexes, and nucleoprotein complexes from the CYTOPLASM into the EXTRACELLULAR SPACE or into recipient cells. T4SSs are found in GRAM-NEGATIVE BACTERIA, while homologous components to T4SSs are found in GRAM-POSTIVE BACTERIA.


Female Genital Diseases
Genital Diseases, Female
Gynecologic Diseases

Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).


Acoustic Phonons
Phonon
Phonons
Optical Phonons

Phonons generated by the effect of light on some crystals.


Perineural Cysts
Sacral Tarlov Cysts
Tarlov Cysts
Perineurial Cysts
Sacral Perineural Cysts

Perineurial cysts commonly found in the SACRAL REGION. They arise from the PERINEURIUM membrane within the SPINAL NERVE ROOTS. The distinctive feature of the cysts is the presence of spinal nerve root fibers within the cyst wall, or the cyst cavity itself.


The amount of PLASMA that perfuses the KIDNEYS per unit time, approximately 10% greater than effective renal plasma flow (RENAL PLASMA FLOW, EFFECTIVE). It should be differentiated from the RENAL BLOOD FLOW; (RBF), which refers to the total volume of BLOOD flowing through the renal vasculature, while the renal plasma flow refers to the rate of plasma flow (RPF).


Rare autosomal recessive syndrome characterized by delayed closing of CRANIAL SUTURES, short stature, ACRO-OSTEOLYSIS of distal phalanges, dental and MAXILLOFACIAL ABNORMALITIES and an increase in bone density that results in frequent BONE FRACTURES. It is associated with BONE RESORPTION defect due to mutations in the lysosomal cysteine protease CATHEPSIN K.


Glandulae Tarsales
Meibomian Glands
Tarsal Glands

The sebaceous glands situated on the inner surface of the eyelids between the tarsal plates and CONJUNCTIVA.


Oncolytic Virotherapy
Oncolytic Virus Therapy
Virotherapy, Oncolytic

Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.


Pheresis
Blood Component Removal
Apheresis

Any procedure in which blood is withdrawn from a donor, a portion is separated and retained, at the same time the remainder is returned to the donor.


A neural tract which connects the TECTUM MESENCEPHALI and the SPINAL CORD and is involved in head and eye movement coordination.


Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted

Parenterally-Transmitted Non-A, Non-B Hepatitis

INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.


An enzyme that catalyzes reversibly the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to yield phosphatidylethanolamine (cephalin) and CMP. The enzyme is found in the endoplasmic reticulum. EC 2.7.8.1.


A plant genus of the family MALVACEAE. It is the source of COTTON FIBER; COTTONSEED OIL, which is used for cooking, and GOSSYPOL. The economically important cotton crop is a major user of agricultural PESTICIDES.


Transient Receptor Potential Cation Channel Subfamily A, Member 1

A highly conserved, non-selective TRP cation channel  that contains 14-17 ANKYRIN REPEATS. It functions in cold sensation and NOCICEPTION of endogenous inflammatory factors and volatile irritants. TRPA1 is also activated by CANNABINOIDS and may play a role in sound perception by hair cells of the inner ear.


Genetic Transduction
Transduction, Genetic

The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.


L-Kynurenine-3-Hydroxylase
Kynurenine 3-Monooxygenase
Kynurenine Hydroxylase
Kynurenine 3-Hydroxylase

An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3-hydroxykynurenine. It was formerly characterized as EC 1.14.1.2 and EC 1.99.1.5.


Occupational Burnout
Burnout, Professional
Career Burnout

An excessive stress reaction to one's occupational or professional environment. It may be characterized by feelings of emotional and physical exhaustion, coupled with a sense of frustration and failure.


Cytidine Phosphates
Cytosine Nucleotides

A group of pyrimidine NUCLEOTIDES which contain CYTOSINE.


Congenital Ichthyosiform Erythroderma, Dry Type

Congenital Ichthyosiform Erythroderma, Wet Type

Designation for several severe forms of ichthyosis, present at birth, that are characterized by hyperkeratotic scaling. Infants may be born encased in a collodion membrane which begins shedding within 24 hours. This is followed in about two weeks by persistent generalized scaling. The forms include bullous (HYPERKERATOSIS, EPIDERMOLYTIC), non-bullous (ICHTHYOSIS, LAMELLAR), wet type, and dry type.


Interferon beta 1a
Avonex Pen
Avonex
Interferon beta-1a
Rebif

An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS.


P450 CYP2E1 Inhibitors
Cytochrome P-450 CYP2E1 Inhibitors
CYP2E1 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2E1.


A plant genus of the family Orobanchaceae that is parasitic on the roots of other plants. Members contain the flavones, APIGENIN and LUTEOLIN.


Phenylalanine-Hydroxylase Deficiency Disease, Maternal

Maternal Phenylalanine Hydroxylase Deficiency Disease

A condition occurring in untreated or partially treated females with PHENYLKETONURIA when they become pregnant. This may result in damages to the FETUS, including MICROCEPHALY; MENTAL RETARDATION; congenital heart disease; FETAL GROWTH RETARDATION; and CRANIOFACIAL ABNORMALITIES. (From Am J Med Genet 1997 Mar 3;69(1):89-95)


Voltage-Dependent Anion Channel 2
VDAC2 Protein

Voltage-dependent anion channel 2 is a low abundance mammalian isoform of VDAC that interacts with the inactive form of BAK PROTEIN.


Mammaglobin-B
Lacryglobin
Secretoglobin family 2A member 1
Mammaglobin B
Mammaglobin-2
Lipophilin-C

A MAMMAGLOBIN A-related secretoglobin that is expressed in several HUMAN tissues including the UTERUS; BREAST; SALIVARY GLAND; and LACRIMAL GLAND.


Shiga Toxin
Stx Protein
Shigella Toxin
Stx Protein, Shigella dysenteria
Shigella Cytotoxin

A toxin produced by SHIGELLA DYSENTERIAE. It is the prototype of class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA, RIBOSOMAL) with PEPTIDE ELONGATION FACTORS.


Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.


HLA Class I Histocompatibility Antigen, B-39 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*39 allele family.


Employment, Supported
Supported Employment

Paid work for mentally or physically disabled persons, taking place in regular or normal work settings. It may be competitive employment (work that pays minimum wage) or employment with subminimal wages in individualized or group placement situations. It is intended for persons with severe disabilities who require a range of support services to maintain employment. Supported employment differs from SHELTERED WORKSHOPS in that work in the latter takes place in a controlled working environment. Federal regulations are authorized and administered by the U.S. Department of Education, Office of Special Education and Rehabilitative Services.


Baculoviral IAP Repeat Containing Protein 3

Baculoviral IAP Repeat-Containing 3 Protein

A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. It contains three baculoviral IAP repeats in its N-terminal half, a CARD DOMAIN, and a RING finger domain at its C-terminus. It is highly expressed in fetal lung and kidney, and adult lymphoid tissues such as spleen, thymus, and peripheral blood lymphocytes. It functions in INFLAMMATION signaling, the INNATE IMMUNE RESPONSE, cell growth and proliferation, and metastasis of tumor cells.


Neural Transmission
Neurotransmission
Transmission, Neural
Transmission, Synaptic
Synaptic Transmission

The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.


Fourier Transform
Cyclic Analysis
Analysis, Cyclic
Analysis, Fourier
Fourier Analysis
Fourier Series

Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)


Primary Hyperparathyroidism
Hyperparathyroidism, Primary

A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.


A nonlinear electrophoretic technique used to separate a variety of ionic compounds, ranging from small metal ions to large molecules like proteins. Unlike "linear" zone electrophoresis in which separating solute bands continually spread by diffusion or dispersion, isotachophoresis forms self-sharpening, adjacent zones of substantially pure solute whose concentrations often exceed several mgs/ml. In isotachophoresis a multianalyte sample is introduced between the leading electrolyte and the terminating electrolyte where the sample ions have lower electrophoretic mobilities than the leading ion but larger than the terminating ion. (From "Isotachophoresis" on the AES Web Site [Internet]. Madison, WI: The American Electrophoresis Society; c2000-2008 [cited 2009 Aug 20]. Available from http://www.aesociety.org/areas/isotachophoresis.php)


Student-Run Free Clinic
Resident Run Clinic
Student Run Clinic

A healthcare setting serviced predominantly by medical personnel in training, at no cost to the patients.


Diffusing Capacity, Pulmonary
Capacity, Pulmonary Diffusing
Pulmonary Diffusing Capacity

The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.


Metabolic Detoxification, Phase II
Metabolic Detoxication, Conjugative
Phase II Detoxification
Metabolic Detoxication, Phase II

The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.


NAmPRTase
Pre-B-Cell Colony-Enhancing Factor
Visfatin
Nicotinamide Phosphoribosyltransferase
NMN Pyrophosphorylase
NAMPT Protein

An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).


Liliidae
Liliopsida
Magnoliopsida
Liliatae
Dicotyledoneae
Hamamelididae
Oncothecales
Commelinidae
Magnoliatae
Metteniusales
Asteridae
Caryophyllidae
Dilleniidae
Angiospermae
Angiosperma
Angiosperms
Flowering Plants
Arecidae
Rosidae
Zingiberidae
Hamamelidae
Icacinales
Vahliales

A class of vascular plants which produce flowers and seeds. They include monocotyledons, dicotyledons, and about 80% of all known plant species.


Receptor, EphA4
Cek-8 Kinase
Ephrin Receptor A4
EphA4 Receptor
Sek-1 Receptor Tyrosine Kinase
EphA4 Protein
Receptor Tyrosine Kinase Eph-A4
Eph-A4 Receptor Tyrosine Kinase

An eph family receptor found in variety of tissues including BRAIN. During embryogenesis, EphA4 receptor exhibits a diverse spatial and temporal patterns of expression suggesting its role in multiple developmental processes.


Biological Select Agents
Biological Warfare Agents
Biowarfare Agents
Biological Weapons
Bioterrorism Agents

Living organisms or their toxic products that are used to cause disease or death of humans during WARFARE.


Potassium or potassium compounds used in foods or as foods.


G2 Cell Cycle Checkpoints
G2 Restriction Point
Antephase Checkpoint
G2 Cell Cycle Arrest
G2 Cell Cycle Control
G2 Phase Checkpoints
G2 Phase Cell Cycle Checkpoints
G2-M Cell Cycle Checkpoint

Cell cycle controls at a phase between G2 PHASE and MITOSIS when chromosome condensation is reversible.


Histologic Technic
Histological Technics
Histological Techniques
Histologic Technique
Technic, Histologic
Histologic Technics
Histologic Techniques
Technique, Histologic
Techniques, Histologic
Technics, Histologic

Methods of preparing tissue for examination and study of the origin, structure, function, or pathology.


An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)


Globozoospermia
Teratospermia
Abnormal Spermatozoa
Teratozoospermia

Conditions in which sperm show abnormal morphology.


Hemophilus paragallinarum
Haemophilus paragallinarum

A species of gram-negative bacteria in the genus HAEMOPHILUS, causing respiratory tract disease in CHICKENS known as infectious coryza.


Tonic Pupil, Local
Adie Pupil
Tonic Pupil
Tonic Pupil, Neuropathic
Pupillotonia
Myotonic Pupil
Adie's Pupil
Pupil, Tonic

A pupillary abnormality characterized by a poor pupillary light reaction, reduced accommodation, iris sector palsies, an enhanced pupillary response to near effort that results in a prolonged, "tonic" constriction, and slow pupillary redilation. This condition is associated with injury to the postganglionic parasympathetic innervation to the pupil. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp492-500)


The superficial GRAY MATTER of the CEREBELLUM. It consists of two main layers, the stratum moleculare and the stratum granulosum.


Health Information Exchange
Medical Information Exchange

Organizational framework for the dissemination of electronic healthcare information or clinical data, across health-related institutions and systems. Its overall purpose is to enhance PATIENT CARE.


Retinopathy of Prematurity
Retrolental Fibroplasia

A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)


A family of soluble metal binding proteins that are involved in the intracellular transport of specific metal ions and their transfer to the appropriate metalloprotein precursor.


Antibodies directed against immunogen-coupled phosphorylated PEPTIDES corresponding to amino acids surrounding the PHOSPHORYLATION site. They are used to study proteins involved in SIGNAL TRANSDUCTION pathways. (From Methods Mol Biol 2000; 99:177-89)


Transplantation, Bone
Grafting, Bone
Bone Transplantation

The grafting of bone from a donor site to a recipient site.


Ureaplasma Infections
Infections, Ureaplasma

Infections with bacteria of the genus UREAPLASMA.


Fluoroimmunoassay
Immunofluorometric Assay
Time-Resolved Immunofluorometric Assay

The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.


Abnormalities, Maxillofacial
Maxillofacial Abnormalities

Congenital structural deformities, malformations, or other abnormalities of the maxilla and face or facial bones.


Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.


A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.


Nuclear Receptor Subfamily 2, Group C, Member 2

An orphan nuclear receptor that has specificity for hormone response elements found in the promoters of target genes. It binds DNA either as a homodimer or as heterodimer with the closely-related orphan nuclear receptor NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 1. The protein was originally identified as a TESTES-specific protein and is involved in the regulation of variety of cellular processes, including CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS.


Biliary Surgical Procedures
Surgical Procedures, Biliary
Surgical Procedure, Biliary
Biliary Tract Surgical Procedure
Biliary Surgical Procedure
Biliary Tract Surgical Procedures
Surgical Procedures, Biliary Tract
Surgical Procedure, Biliary Tract

Any surgical procedure performed on the biliary tract.


gamma-Chemokines
Chemokines, C
C Chemokines

Group of chemokines without adjacent cysteines that are chemoattractants for lymphocytes only.


Leuprolide Acetate
Enantone
Leuprolide, (DL-Leu)-Isomer
Leuprorelin
Leuprolide, (L-Leu)-Isomer
TAP-144
A-43818
Leuprolide Monoacetate
Lupron
Leuprolide

A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.


Emphysema, Subcutaneous
Subcutaneous Emphysema

Presence of air or gas in the subcutaneous tissues of the body.


A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.


Photoallergic Contact Dermatitis
Dermatitis, Contact, Photoallergic
Photoallergy
Dermatitis, Photoallergic
Photosensitive Contact Dermatitis
Dermatitis, Photocontact
Dermatitis, Contact, Photosensitive

A delayed hypersensitivity involving the reaction between sunlight or other radiant energy source and a chemical substance to which the individual has been previously exposed and sensitized. It manifests as a papulovesicular, eczematous, or exudative dermatitis occurring chiefly on the light-exposed areas of the skin.


Cyclic GMP
Guanosine Cyclic 3',5'-Monophosphate
Guanosine Cyclic-3',5'-Monophosphate
Guanosine Cyclic Monophosphate
Guanosine Cyclic 3,5 Monophosphate

Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)


Smad Proteins, Receptor-Regulated
Receptor-Regulated Smad Proteins
R-Smad Proteins

A family of smad proteins that undergo PHOSPHORYLATION by CELL SURFACE RECEPTORS in response to TRANSFORMING GROWTH FACTOR BETA; ACTIVIN; or BONE MORPHOGENETIC PROTEIN signaling.


The burning of a small, thimble sized, smoldering plug of dried leaves on the SKIN at an ACUPUNCTURE point. Usually the plugs contain leaves of MUGWORT or moxa.


National Institute of Child Health and Human Development (U.S.)

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Component of the NATIONAL INSTITUTES OF HEALTH. It was initially established to investigate the broad aspects of human development as a means of understanding developmental disabilities, including mental retardation, and the events that occur during pregnancy. It now conducts and supports research on all stages of human development. It was established in 1962.


Diseases of the domestic or wild goat of the genus Capra.


gag-pol Fused Protein
gag-pol Protein
gag-pol Fusion Proteins
Fusion Proteins, gag-pol

Polyprotein products of a fused portion of retroviral mRNA containing the gag and pol genes. The polyprotein is synthesized only five percent of the time since pol is out of frame with gag, and is generated by ribosomal frameshifting.


Sugar analogs in which the ring oxygen is replaced by a sulfur.


Multisection Computed Tomography
Multidetector-Row Computed Tomography
Multislice Computed Tomography
Multidetector Computed Tomography

Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.


Angiography, Radioisotope
Radionuclide Angiography
Angiography, Radionuclide
Radioisotope Angiography

The measurement of visualization by radiation of any organ after a radionuclide has been injected into its blood supply. It is used to diagnose heart, liver, lung, and other diseases and to measure the function of those organs, except renography, for which RADIOISOTOPE RENOGRAPHY is available.


Education, Nursing, Post-Basic
Education, Nursing, Continuing
Education, Nursing, Post-Registration
Nursing Education, Post-Basic
Post-Basic Nursing Education
Continuing Nursing Education
Nursing Education, Continuing
Post-Registration Nursing Education
Nursing Education, Post-Registration

Educational programs designed to inform nurses of recent advances in their fields.


Postresuscitation Disease
Post-Cardiac Arrest Syndrome
Postcardiac Arrest Syndrome

A reperfusion syndrome characterized by various pathophysiological processes after CARDIAC ARREST.  It may include post-cardiac arrest brain injury (HYPOXIA-ISCHEMIA, BRAIN), cardiocirculatory dysfunction, (e.g., systemic ISCHEMIA), HYPERGLYCEMIA; MULTIPLE ORGAN FAILURE and delayed death.


Wake-Promoting Agents
Wake-Promoting Drugs
Wake-Promoting Substances
Eugeroic Drugs
Wakefulness-Promoting Agents

A specific category of drugs that prevent sleepiness by specifically targeting sleep-mechanisms in the brain. They are used to treat DISORDERS OF EXCESSIVE SOMNOLENCE such as NARCOLEPSY. Note that this drug category does not include broadly-acting central nervous system stimulants such as AMPHETAMINES.


The study of laws, theories, and hypotheses through a systematic examination of pertinent facts and their interpretation in the field of dentistry. (From Jablonski, Illustrated Dictionary of Dentistry, 1982, p674)


Mitogen-Activated Protein Kinase Kinase 5

A mitogen-activated protein kinase kinase with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 7.


Migraine without Aura
Common Migraine
Migraine, Common

Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)


Schizophrenia, Hebephrenic
Hebephrenic Schizophrenia
Schizophrenia, Disorganized

A type of schizophrenia characterized by frequent incoherence; marked loosening of associations, or grossly disorganized behavior and flat or grossly inappropriate affect that does not meet the criteria for the catatonic type; associated features include extreme social withdrawal, grimacing, mannerisms, mirror gazing, inappropriate giggling, and other odd behavior. (Dorland, 27th ed)


A metabolite of 17-ALPHA-HYDROXYPROGESTERONE, normally produced in small quantities by the GONADS and the ADRENAL GLANDS, found in URINE. An elevated urinary pregnanetriol is associated with CONGENITAL ADRENAL HYPERPLASIA with a deficiency of STEROID 21-HYDROXYLASE.


Osteotomy, Sagittal Split Ramus
Sagittal Split Ramal Osteotomy
Sagittal Split Ramus Osteotomy

Sagittal sectioning and repositioning of the ramus of the MANDIBLE to correct a mandibular retrusion, MALOCCLUSION, ANGLE CLASS III; and PROGNATHISM. The oblique sectioning line consists of multiple cuts horizontal and vertical to the mandibular ramus.


Infections, Morbillivirus
Morbillivirus Infections

Infections with viruses of the genus MORBILLIVIRUS, family PARAMYXOVIRIDAE. Infections mainly cause acute disease in their hosts, although in some cases infection is persistent and leads to degenerative conditions.


A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)


Phenols substituted in any position by an amino group.


Whole Transcriptome Shotgun Sequencing
RNA-Seq

High-throughput nucleotide sequencing techniques developed for determining and analyzing the composition of the TRANSCRIPTOME of a sample.


Lactococcus lactis
Lactococcus lactis subsp. lactis
Streptococcus lactis

A non-pathogenic species of LACTOCOCCUS found in DAIRY PRODUCTS and responsible for the souring of MILK and the production of LACTIC ACID.


HuD Paraneoplastic Encephalomyelitis Antigen

An RRM protein which binds AU-rich sequences in the 3' UNTRANSLATED REGIONS of mRNAs for PROTO-ONCOGENE PROTEINS C-FOS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; and GAP-43 PROTEIN. It functions in neuron-specific RNA processing.


Nucleus Shape, Cell
Cell Nuclear Shape
Cell Nucleus Shape
Nuclear Shape, Cell

The quality of surface form or outline of the CELL NUCLEUS.


Sweet Almond
Amygdalus communis
Almonds
Almond Tree
Prunis communis
Prunus dulcis
Prunus amygdalus

Nuts from almond tree and from which almond oil is pressed.


Anapolon 50
Oxymetholone
Anadrol
Hydroxymetholone
Oxymetholone, (5 alpha,17 alpha)-Isomer
Oxymetholone, (17 beta)-Isomer
Oxymethalone

A synthetic hormone with anabolic and androgenic properties. It is used mainly in the treatment of anemias. According to the Fourth Annual Report on Carcinogens (NTP 85-002), this compound may reasonably be anticipated to be a carcinogen. (From Merck Index, 11th ed)


Total Elbow Replacement
Elbow Replacement Arthroplasty
Arthroplasty, Replacement, Elbow


Anti-HIV Drugs
Anti-HIV Agents
Anti-AIDS Agents
Anti-AIDS Drugs
AIDS Drugs

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.


PH Domain
Pleckstrin Homology Domains
PH Domains
Pleckstrin Homology Domain

Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of  HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.


Phosphotransbutyrylase
Phosphoacylase
Phosphate Acetyltransferase
Phosphotransacetylase
Phosphotransacylase

An enzyme that catalyzes the synthesis of acetylphosphate from acetyl-CoA and inorganic phosphate. Acetylphosphate serves as a high-energy phosphate compound. EC 2.3.1.8.


National Institute of Neurological Disorders and Stroke (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It supports and conducts research, both basic and clinical, on the normal and diseases nervous system. It was established in 1950.


A group of flagellated, mostly symbiotic EUKARYOTES characterized by twofold symmetry associated with the presence of a pair of karyomastigont organellar systems. Two nuclei are attached by fibers to the flagella and there are no MITOCHONDRIA. Diplomonadida were formerly members of the class Zoomastigophora in the old five kingdom paradigm.


Psychological Extinction
Extinction (Psychology)
Extinction, Psychological

The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.


Epitopes, B-Lymphocyte
B-Cell Epitope
B-Cell Epitopes
B-Lymphocyte Epitope
B-Lymphocyte Epitopes

Antigenic determinants recognized and bound by the B-cell receptor. Epitopes recognized by the B-cell receptor are located on the surface of the antigen.


Interleukin-1 Receptor-Like 1 Protein
Interleukin-33 Receptor
Interleukin 1 Receptor-Related Protein
IL1RL1 Protein

A receptor for INTERLEUKIN-33 that is related structurally to the interleukin-1 receptor. It  contains three extracellular IMMUNOGLOBULIN-LIKE DOMAIN regions and associates with INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN upon binding IL-33 to initiate signaling. It may function in the response of HELPER T CELLS to INFLAMMATION.


An order of BIRDS comprised of several families and more than 300 species. It includes COCKATOOS; PARROTS; PARAKEETS; macaws; and BUDGERIGARS.


Chondroitin-Sulfate-ABC Endolyase
Chondroitin ABC Lyase
Chondroitinase ABC

An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)


Sulformethoxine
Sulphormetoxin
Sulforthomidine
Sulfadoxine
Sulphorthodimethoxine
Sulformetoxine
Ro 4-4393
Fanasil

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.


beta-Hexosaminidase alpha Chain
beta-N-Acetylhexosaminidase alpha Chain
Hexosaminidase A, alpha Chain

The alpha subunit of hexosaminidase A. Mutations in the gene that encodes this protein can result in loss of hexosaminidase A activity and are linked to TAY-SACHS DISEASE.


Synapsis
Synapsis, Chromosomal
Chromosome Pairing

The alignment of CHROMOSOMES at homologous sequences.


Epistropheus
Axis, Cervical Vertebra
Os Odontoideum
Cervical Vertebra Axis
C2 Vertebra

An anatomical variant of the cervical vertebra axis in which the ODONTOID PROCESS is unfused from the body of the axis.


Phospholipase A2 Receptors
PLA(2) Receptor
Receptor, Phospholipase A2
Phospholipase A2 Receptor
Receptors, Phospholipase A2

Cell surface receptors that bind to and internalize SECRETED PHOSPHOLIPASES A2. Although primarily acting as scavenger receptors, these proteins may also play a role in intracellular signaling. Soluble forms of phospholipase A2 receptors occur through the action of proteases and may a play a role in the inhibition of extracellular phospholipase activity.


Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44)


CpG-Rich Islands
CpG Clusters
CpG Islands

Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.


Prolongation of Life
Life Support Care
Extraordinary Treatment

Care provided patients requiring extraordinary therapeutic measures in order to sustain and prolong life.


Neisseriaceae Infections
Infections, Neisseriaceae

Infections with bacteria of the family NEISSERIACEAE.


Hallucinogenic Drugs
Hallucinogenic Agents
Psychedelic Agents
Hallucinogens
Hallucinogenic Substances
Psychedelics
Psychotomimetic Agents

Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise.


The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.


Innovation Diffusion
Diffusion of Innovation

The broad dissemination of new ideas, procedures, techniques, materials, and devices and the degree to which these are accepted and used.


Glossitis, Benign Migratory
Erythema Migrans, Lingual
Geographic Tongue
Glossitis Areata Exfoliativa
Tongue, Geographic

An idiopathic disorder of the tongue characterized by the loss of filiform papillae leaving reddened areas of circinate macules bound by a white band. The lesions heal, then others erupt.


Antibodies, Monoclonal
Monoclonal Antibodies

Antibodies produced by a single clone of cells.


Sex Chromosome Disorders of Sex Development

Congenital conditions of atypical sexual development associated with abnormal sex chromosome constitutions including MONOSOMY; TRISOMY; and MOSAICISM.


Cullin Proteins
Cullin Protein
Cullins
Cullin Domain Proteins
Cullin Domain Protein

A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. They play important roles in regulation of the CELL CYCLE and as components of UBIQUITIN-PROTEIN LIGASES.


A childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL. (Stedman, 25th ed)


Solomon Seal
Solomon's Seal
Smilacina, False
Polygonatum
Solomon's-seal
False Smilacina

A plant genus of the family Asparagaceae. Members contain benzoquinones, steroidal saponin, and ribosome-inactivating proteins.


Truth Disclosure
Disclosure, Error
Disclosure, Truth

Truthful revelation of information, specifically when the information disclosed is likely to be psychologically painful ("bad news") to the recipient (e.g., revelation to a patient or a patient's family of the patient's DIAGNOSIS or PROGNOSIS) or embarrassing to the teller (e.g., revelation of medical errors).


Poxvirus Infections
Infections, Poxvirus
Infections, Poxviridae
Milker's Nodes
Poxviridae Infections

Virus diseases caused by the POXVIRIDAE.


Abnormal concretion or calcified deposit that forms around the teeth or dental prostheses.


TAF (TATA-Associated Factors)
TBP-Associated Factor
TATA-Binding Protein Associated Factors
TBP-Associated Factors

Factors that associate with TATA-BOX BINDING PROTEIN. Many of them are components of TRANSCRIPTION FACTOR TFIID


Diseases, Peripheral Vascular
Peripheral Vascular Diseases
Vascular Diseases, Peripheral
Peripheral Angiopathies

Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.


Body Contour Surgery
Body Contouring
Body Lift Surgery
Body Contouring Surgery

Plastic surgery to shape many areas of the body simultaneously. This may include LIPECTOMY or RHYTIDOPLASTY or both.


A plant genus of the family OLEACEAE. Members contain suspensaside.


Schistosomal Myelitis
Schistosomal Myelopathy
Neuroschistosomiasis
Central Nervous System Schistosomiasis
Schistosomiasis, Central Nervous System
Schistosomal Myeloradiculopathy

SCHISTOSOMIASIS of the brain, spinal cord, or meninges caused by infections with trematodes of the genus SCHISTOSOMA (primarily SCHISTOSOMA JAPONICUM; SCHISTOSOMA MANSONI; and SCHISTOSOMA HAEMATOBIUM in humans). S. japonicum infections of the nervous system may cause an acute meningoencephalitis or a chronic encephalopathy. S. mansoni and S. haematobium nervous system infections are associated with acute transverse myelitis involving the lower portions of the spinal cord. (From Joynt, Clinical Neurology, 1998, Ch27, pp61-2)


Posterior Cerebellar Commissure
Posterior Commissure, Cerebellar

A bundle of nerve fibers that crosses the midline in the tectum mesencephali dorsal to the CEREBRAL AQUEDUCT.


Toxicologic Phenomenon
Toxicological Phenomenon
Toxicological Concepts
Toxicological Phenomena
Toxicologic Phenomena

The nature and effects of chemical, physical or biological poisons on living organisms.


Angiogranuloma
Granuloma Telangiecticum
Hemangioma, Lobular Capillary
Granuloma Pyogenicum
Granuloma, Pyogenic

A disorder of the skin, the oral mucosa, and the gingiva, that usually presents as a solitary polypoid capillary hemangioma often resulting from trauma. It is manifested as an inflammatory response with similar characteristics to those of a granuloma.


Carbon-Carbon Double Bond Isomerases
C-C Double Bond Isomerases

Enzymes that catalyze the shifting of a carbon-carbon double bond from one position to another within the same molecule. EC 5.3.3.


AL-1
Repulsive Axon Guidance Signal Protein
REK7 Ligand AL-1
AL-1 Protein
Ephrin-A5
RAGS Protein
LERK-7 Protein

A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It has been shown to mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It is found in a variety of adult tissues of BRAIN; HEART; and KIDNEY.


PSML
Sorbitan Derivatives
Polysorbate 20
Tween 85
Polysorbates
Tween 81
Tweens
Polyoxyethylene Sorbitan Monolaurate
Polysorbate 80
Tween 80
Tween 60
Tween 20

Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.


Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.


Spectrometry, Fluorescence
Fluorescence Spectroscopy
Fluorescence Spectrophotometry
Spectrofluorometry

Measurement of the intensity and quality of fluorescence.


A genus of snakes of the subfamily Crotalinae, having a hollowed out pit in the maxillary bone between the eye and nostril. Most of the recognized species are found in the southwestern United States and northern Mexico. Several species are found as far north as Canada and east of the Mississippi, including southern Appalachia. They are named for the jointed rattle (Greek krotalon) at the tip of their tail. (Goin, Goin, and Zug: Introduction to Herpetology, 3d ed; Moore: Poisonous Snakes of the World, 1980, p335).


Epidemic, Opioid
Opioid Crisis
Opiate Epidemic
Opioid Epidemic

Widespread use of OPIOIDS by disproportionately large numbers of individuals within a population, community, or region occurring within a relatively narrow window of time.


Voltage-Gated Potassium Channel
Kv Potassium Channels
Voltage-Gated K+ Channels
Voltage-Gated Potassium Channels
Potassium Channel, Voltage-Gated
Potassium Channels, Voltage-Gated

Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.


Cdh1 Subunit, Anaphase-Promoting Complex

Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication.


Cerebromedullospinal Disconnection
Locked-In Syndrome
Ventral Pontine Syndrome

Acquired neuromuscular disorder characterized by complete paralysis of voluntary muscles and lower CRANIAL NERVES except for limited voluntary eye movements. It is due to various cerebrospinal disconnections at or near the PONS and the POSTERIOR CRANIAL FOSSA, typically secondary to pontine hemorrhage or infarct. Because cognitive function is intact it is sometimes referred to as a pseudocoma state.


Peritoneal Lavage
Lavage, Peritoneal
Peritoneal Irrigation
Irrigation, Peritoneal

Washing out of the peritoneal cavity. The procedure is a diagnostic as well as a therapeutic technique following abdominal trauma or inflammation.


Systolic Heart Failure
Heart Failure, Systolic

Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.


Lymphadenopathy, Immunoblastic
Immunoblastic Lymphadenopathy
Angioimmunoblastic Lymphadenopathy

A disorder characterized by proliferation of arborizing small vessels, prominent immunoblastic proliferations and amorphous acidophilic interstitial material. Clinical manifestations include fever, sweats, weight loss, generalized lymphadenopathy and frequently hepatosplenomegaly.


Intravenous Anesthetics
Anesthetics, Intravenous

Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)


Uridine Diphosphate Glucuronic Acid
UDPGA
Uridine Diphosphoglucuronic Acid
UDP Glucuronic Acid

A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones.


Receptor, Muscarinic M2
Muscarinic Receptor M2
Muscarinic Receptors M2
Receptors, Muscarinic M2

A specific subtype of muscarinic receptor found in the lower BRAIN, the HEART and in SMOOTH MUSCLE-containing organs. Although present in smooth muscle the M2 muscarinic receptor appears not to be involved in contractile responses.


ADAM (A Disintegrin and Metalloprotease) Proteins

A Disintegrin and Metalloprotease Proteins

A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain.


Chimpanzee
Chimpanzee troglodytes
Pan troglodytes

The common chimpanzee, a species of the genus Pan, family HOMINIDAE. It lives in Africa, primarily in the tropical rainforests. There are a number of recognized subspecies.


Trager duck spleen necrosis virus
Spleen Necrosis Virus

A species in the group RETICULOENDOTHELIOSIS VIRUSES, AVIAN of the genus GAMMARETROVIRUS originally isolated from ducks.


Mesothelial Neoplasms
Neoplasms, Mesothelial

Neoplasms composed of tissue of the mesothelium, the layer of flat cells, derived from the mesoderm, which lines the body cavity of the embryo. In the adult it forms the simple squamous epithelium which covers all true serous membranes (peritoneum, pericardium, pleura). The concept does not refer to neoplasms located in these organs. (From Dorland, 27th ed)


Ileojejunal Bypass
Jejunoileal Bypass
Intestinal Bypass
Jejuno-Ileal Bypass

A procedure consisting of the SURGICAL ANASTOMOSIS of the proximal part of the JEJUNUM to the distal portion of the ILEUM, so as to bypass the nutrient-absorptive segment of the SMALL INTESTINE. Due to the severe malnutrition and life-threatening metabolic complications, this method is no longer used to treat MORBID OBESITY.


Human Experimentation, Nontherapeutic
Research, Nontherapeutic
Nontherapeutic Human Experimentation
Nontherapeutic Research

Human experimentation that is not intended to benefit the subjects on whom it is performed. Phase I drug studies (CLINICAL TRIALS, PHASE I AS TOPIC) and research involving healthy volunteers are examples of nontherapeutic human experimentation.


Works about a written account of a person's life and the branch of literature concerned with the lives of people.


Forkhead Transcription Factors
Forkhead Proteins
Forkhead Box Transcription Factors
Fox Transcription Factors
Forkhead Box Proteins

A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.


Receptors, Parathyroid Hormone
Parathyroid Hormone Receptors

Cell surface proteins that bind PARATHYROID HORMONE with high affinity and trigger intracellular changes which influence the behavior of cells. Parathyroid hormone receptors on BONE; KIDNEY; and gastrointestinal cells mediate the hormone's role in calcium and phosphate homeostasis.


PC-3 (Human Prostatic Carcinoma) Cell Line

An epithelial cell line initiated from a human bone metastasis of a grade IV prostatic ADENOCARCINOMA.


Economic aspects of the field of medicine, the medical profession, and health care. It includes the economic and financial impact of disease in general on the patient, the physician, society, or government.


Biological Adaptation
Adaptation, Biologic
Adaptation, Biological

Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.


Catheters, Indwelling
Implantable Catheters
In-Dwelling Catheters

Catheters designed to be left within an organ or passage for an extended period of time.


3-Mercaptopropionic Acid
3-Mercaptopropanoic Acid
beta-Mercaptopropionate

An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.


Coronavirus 229E, Human
Human Coronavirus 229E
HCoV-229E

A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.


Adipocyte Complement-Related Protein 30-kDa

Adipocyte, C1q and Collagen Domain Containing Protein

A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.


Cerebral Primitive Neuroectodermal Tumor

A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)


Renal Calculus
Nephrolith
Kidney Stones
Renal Calculi
Kidney Calculi

Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.


Muscle Cells, Cardiac
Myocytes, Cardiac
Cardiomyocytes
Muscle Cells, Heart

Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).


Arachidonate 5-Lipoxygenase Activating Proteins

Scaffolding proteins that play an important role in the localization and activation of 5-LIPOXYGENASE.


Sodium Dithionite
Hyposulfite
Dithionite

Dithionite. The dithionous acid ion and its salts.


Derivatives of phosphatidic acid in which the hydrophobic regions are composed of two fatty acids and a polar alcohol is joined to the C-3 position of glycerol through a phosphodiester bond. They are named according to their polar head groups, such as phosphatidylcholine and phosphatidylethanolamine.


A form of psychotherapy with emphasis on the interplay of organism and environment. Basic to this therapy is the development of awareness and maturity, as well as self-confidence.


Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.


Arp2-3 Protein Complex
Actin-Related Protein 2-3 Complex
Arp2-3 Complex

A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.


Watchful Waiting
Expectant Management
Active Surveillance

Clinical management approach wherein immediate therapy is not provided but there is a period of observation during which periodic tests monitor patient and the progression of the illness. (Driffield T, Smith PC Med Decis Making. 2007 Mar-Apr;27(2):178-88)


Endopiriform Claustrum
Insular Claustrum
Claustrum
Claustra

A gray matter lamina located underneath the inner NEOCORTEX lateral to the PUTAMEN and medial to the INSULAR CORTEX. It is considered to be a part of the basal ganglia. Extensive claustral projections exist to most cortices and subcortical structures including the AMYGDALA, the CAUDATE NUCLEUS, the HIPPOCAMPUS and the THALAMUS.


The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.


Hemorrhagic Fever, Korean
HFRS
Hemorrhagic Nephroso-Nephritis
Hemorrhagic Fever with Renal Syndrome
Nephropathia Epidemica
Hemorrhagic Fever, Epidemic

Mild form of HFRS rarely hemorrhagic and seldom fatal. Caused by the PUUMALA VIRUS.


Bacterial Genomes
Bacterial Genome
Genomes, Bacterial
Genome, Bacterial

The genetic complement of a BACTERIA as represented in its DNA.


Bacteria that can survive and grow in the complete, or nearly complete absence of oxygen.


Fanconi Anemia Complementation Group N Protein

A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.


Fetal Distress
Nonreassuring Fetal Status

A nonreassuring fetal status (NRFS) indicating that the FETUS is compromised (American College of Obstetricians and Gynecologists 1988). It can be identified by sub-optimal values in FETAL HEART RATE; oxygenation of FETAL BLOOD; and other parameters.


Parasitic Infections
Parasitic Diseases
Parasite Infections

Infections or infestations with PARASITES. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.


PDE5 Inhibitors
Phosphodiesterase Type 5 Inhibitors
PDE-5 Inhibitors
Phosphodiesterase 5 Inhibitors

Compounds that specifically inhibit PHOSPHODIESTERASE 5.


Heterotrimeric GTP-Binding Proteins
Heterotrimeric G-Proteins

GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.


Organizational Culture
Corporate Culture

Beliefs and values shared by all members of the organization. These shared values, which are subject to change, are reflected in the day to day management of the organization.


Anti-HAV
Hepatitis A Virus Antibodies
Hepatitis A Antibodies

Antibodies to the HEPATITIS A ANTIGENS including antibodies to envelope, core, and non-structural proteins.


Stimulants (Historical)
Tonics, Historical
Stimulants, Historical

Historical remedies or medicinal preparations believed to have the power of invigorating or promoting restoration of tissues or the body.


tert-Butylhydroperoxide
tertiary-Butylhydroperoxide
t-Butylhydroperoxide
tert-Butyl Hydroperoxide
t-Butyl Hydroperoxide

A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.


An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).


Unc-51 Like Autophagy Activating Kinase 1

A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.


Thermoduric Bacteria
Bacteria, Thermoduric

Bacteria resistant to high temperatures, as in PASTEURIZATION.


Cytomegaloviral Retinitis
Retinitis, Cytomegalovirus
Cytomegalovirus Retinitis

Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.


Malignant Eccrine Poroma
Eccrine Porocarcinoma

A rare malignant neoplasm of the sweat glands. It most often develops as a form of degenerative progression from a benign ECCRINE POROMA.


Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.


Acidic Amino Acid Transport Proteins
Amino Acid Transport Systems, Acidic
Amino Acid Transport Systems, Anionic
Anionic Amino Acid Transport Systems
Acidic Amino Acid Transport Systems
Anionic Amino Acid Transport Proteins
Anionic Amino Acid Transporters
Acidic Amino Acid Transporters

Amino acid transporter systems capable of transporting acidic amino acids (AMINO ACIDS, ACIDIC).


Lactation, Prolonged
Lactation
Milk Secretion

The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.


GLYCEROL esterified with a single acyl (FATTY ACIDS) chain.


Neurinoma
Schwannomatosis, Plexiform
Neurilemmoma
Schwannoma
Neurilemoma

A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)


Non-Nutritive Sweeteners
Artificial Sweeteners, Non-Nutritive
High-Intensity Sweeteners

Chemical additives, such as aspartame, saccharin, and sucralose, that give a sweet taste to foods without contributing significant calories or promoting tooth decay. They are generally much sweeter than sucrose.


Indirect Thrombin Inhibitors
Anticoagulant Agents
Anticoagulant
Anticoagulant Drugs
Anticoagulation Agents
Anticoagulants


Integration, Prophage
Lysogeny
Prophage Integration

The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.


Controlled Clinical Trials as Topic
Clinical Trials, Controlled as Topic

Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.


Receptors, H2
Receptors, Histamine H2
H2 Receptors
Histamine H2 Receptors

A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)


NADH2 Tetrazolium Reductase
NADH Tetrazolium Reductase
NAD(P)H Nitroblue Tetrazolium Reductase

Catalyzes the reduction of tetrazolium compounds in the presence of NADH.


A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for CONTRACEPTION.


Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.


Carotid Endarterectomy
Endarterectomy, Carotid

The excision of the thickened, atheromatous tunica intima of a carotid artery.


I kappa B
I-kappa B Proteins
IkB DNA-Binding Proteins
I-kappa B

A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.


Characteristics, properties, and effects of magnetic substances and magnetic fields.


RNA, Transfer, Gln
tRNAGln
Transfer RNA, Gln
tRNA(Gln)
Glutamine-Specific tRNA

A transfer RNA which is specific for carrying glutamine to sites on the ribosomes in preparation for protein synthesis.


gamma-Carboxyglutamic Acid
3-Amino-1,1,3-propanetricarboxylic Acid
1-Carboxyglutamic Acid
gamma-Carboxyglutamate

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.


Major Basic Protein, Eosinophil
Eosinophil Major Basic Protein
MBP Protein, Eosinophil
Eosinophil Basic Protein

One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil major basic protein is a 14-kDa cytotoxic peptide with a pI of 10.9. In addition to its direct cytotoxic effects, it stimulates the release of variety of INFLAMMATION MEDIATORS.


Mulibrey Nanism
Muscle-Liver-Brain-Eye Nanism
Perheentupa Syndrome
Nanism, Mulibrey
Mulibrey Nanism Syndrome

Growth failure from birth that is due to mutations in a gene (TRIM37) on chromosome 17q22-q23 which encodes a RING-B-box-coiled-coil protein.


Home Blood Glucose Monitoring
Blood Sugar Self-Monitoring
Self-Monitoring, Blood Glucose
Glucose, Blood, Self Monitoring
Glucose, Blood, Self-Monitoring
Monitoring, Home Blood Glucose
Blood Glucose Self-Monitoring

Self evaluation of whole blood glucose levels outside the clinical laboratory. A digital or battery-operated reflectance meter may be used. It has wide application in controlling unstable insulin-dependent diabetes.


Fat Shaming
Weight Prejudice
Obesity Bias
Weight-based Discrimination

Negative attitudes towards and beliefs about others because of their weight. These negative attitudes are manifested by stereotypes and/or prejudice towards people with weight over or under a cultural norm.


Acupuncture, Auricular
Auricular Acupuncture
Acupuncture, Ear
Ear Acupuncture

Acupuncture therapy by inserting needles in the ear. It is used to control pain and for treating various ailments.


MG Dysfunction
Meibomian Gland Dysfunction

A chronic dysfunction of MEIBOMIAN GLANDS characterized by altered tear film stability and function due to a decrease or alteration in lipid quality/content in meibum. It is often associated with evaporative-type DRY EYE SYNDROME.


A synthetic polymer which agglutinates red blood cells. It is used as a heparin antagonist.


Substances that are recognized by the immune system and induce an immune reaction.


Tumor Necrosis Factor-like Weak Inducer of Apoptosis Receptor

Tumor Necrosis Factor Receptor Superfamily, Member 12A

A receptor for TWEAK cytokine that is highly expressed by cells in the heart, placenta, and kidney. It plays a role in ANGIOGENESIS and the proliferation of endothelial cells; it may also modulate cellular adhesion to the extracellular matrix.


Tumor Necrosis Factor-a (TNF-a) Inhibitors

Tumor Necrosis Factor-a (TNF-a) Antagonists

Tumor Necrosis Factor-a (TNF-a) Blockers

Compounds or agents that bind to and inhibit the synthesis or activity of TUMOR NECROSIS FACTOR-alpha. Such agents are used to treat inflammatory bowel diseases and other inflammatory diseases.


A species of fruit fly frequently used in genetics because of the large size of its chromosomes.


Biofuels
Biofuel Oils
Biofuel
Biodiesel
Biogas

Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).


Aromatic diamine used in the plastics industry as curing agent for epoxy resins and urethane rubbers. It causes bladder, liver, lung, and other neoplasms.


Centesis
Culdocentesis
Puncture and Drainage
Paracentesis
Puncture and Aspiration

Withdrawal of PERITONEAL FLUID from the DOUGLAS' POUCH.


Dimethyl Suberimidate
Bismethyl Suberimidate
Dimethylsuberimidate

The methyl imidoester of suberic acid used to produce cross links in proteins. Each end of the imidoester will react with an amino group in the protein molecule to form an amidine.


Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.


Duties that are based in ETHICS, rather than in law.


Hybridization, Genetic
Hybridization, Intraspecies
Crossbreeding

The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.


Care provided the pregnant woman in order to prevent complications, and decrease the incidence of maternal and prenatal mortality.


Muscle Cramp
Cramp
Limb Cramp
Muscular Cramp

A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)


Idiopathic Tropical Malabsorption Syndrome

A chronic malabsorption syndrome, occurring mainly in residents of or visitors to the tropics or subtropics. The failed INTESTINAL ABSORPTION of nutrients from the SMALL INTESTINE results in MALNUTRITION and ANEMIA that is due to FOLIC ACID deficiency.


Health Services, Maternal
Services, Maternal Health
Maternal Health Services

Organized services to provide health care to expectant and nursing mothers.


Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANGIOTENSIN SYSTEM. These include angiotensins derived naturally from precursor ANGIOTENSINOGEN, and those synthesized.


Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.


Imprinting, Molecular
Molecular Imprinting

A methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for molecularly imprinted polymers (MIPs) include separations, assays and biosensors, and catalysis.


Facial Spasm, Unilateral
Hemifacial Myokymia
Spasm, Hemifacial
Hemifacial Spasm

Recurrent clonic contraction of facial muscles, restricted to one side. It may occur as a manifestation of compressive lesions involving the seventh cranial nerve (FACIAL NERVE DISEASES), during recovery from BELL PALSY, or in association with other disorders. (From Adams et al., Principles of Neurology, 6th ed, p1378)


Benzyl Carbinol
beta-Phenylethanol
Phenylethyl Alcohol
2-Phenylethanol
Phenethyl Alcohol
Phenylethanol

An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.


Intraventricular Septal Defects
Heart Septal Defects, Ventricular
Ventricular Septal Defect
Ventricular Septal Defects

Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.


Antidepressants, Tricyclic
Tricyclic Antidepressive Agents
Antidepressive Agents, Tricyclic
Antidepressant Drugs, Tricyclic

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.


MicroRNAs found in cell-free BODY FLUIDS such as SERUM; PLASMA; SALIVA; OR URINE.


L-myc Genes
v-myc Oncogenes
N-myc Genes
L-myc Proto-Oncogenes
N-myc Proto-Oncogenes
c-myc Proto-Oncogenes
Genes, myc
myc Oncogene
c-myc Genes
myc Genes
v-myc Genes

Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.


Monobactams
Antibiotics, Monobactam
Monocyclic beta-Lactams
beta-Lactams, Monocyclic

Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.


Adenosine A2B Receptor
Adenosine A(2B) Receptor
Adenosine A2B Receptors
Receptor, Adenosine A2B

A subclass of adenosine A2 receptors found in the CECUM, the COLON, the BLADDER, and a variety of other tissues. It is generally considered to be a low affinity receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.


Erythroid-Specific Nuclear Factors
Erythroid-Specific DNA-Binding Factors

A group of transcription factors that were originally described as being specific to ERYTHROID CELLS.


Awareness During Anesthesia
Anesthesia Awareness
Intraoperative Awareness

Occurence of a patient becoming conscious during a procedure performed under GENERAL ANESTHESIA and subsequently having recall of these events. (From Anesthesiology 2006, 104(4): 847-64.)


Electrodeposition
Metal Plating
Electroplating

Coating with a metal or alloy by electrolysis.


Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.


A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.


Osteoarthritis of the Hip
Osteoarthritis Of Hip
Osteoarthritis, Hip
Coxarthrosis

Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.


Nucleolus Organizer Region
Nucleolar Organizer

The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.


Radionuclide ventriculography where a bolus of radionuclide is injected and data are recorded from one pass through the heart ventricle. Left and right ventricular function can be analyzed independently during this technique. First-pass ventriculography is preferred over GATED BLOOD-POOL IMAGING for assessing right ventricular function.


Dopar Levopa Dopaflex L-3,4-Dihydroxyphenylalanine 3-Hydroxy-L-tyrosine L-Dopa Levodopa Larodopa

The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.


Tooth Demineralization
Demineralization, Tooth
Tooth Hypomineralization
Hypomineralization, Tooth

A tooth's loss of minerals, such as calcium in hydroxyapatite from the tooth matrix, caused by acidic exposure. An example of the occurrence of demineralization is in the formation of dental caries.


A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.


Cytochromes b6
Cytochrome b6
Apocytochrome b6

Cytochromes of the b group that are found as components of the CYTOCHROME B6F COMPLEX. They contain two non-covalently bound HEME B groups.


The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.


Simple rapid heartbeats caused by rapid discharge of impulses from the SINOATRIAL NODE, usually between 100 and 180 beats/min in adults. It is characterized by a gradual onset and termination. Sinus tachycardia is common in infants, young children, and adults during strenuous physical activities.


A person 65 through 79 years of age. For a person older than 79 years, AGED, 80 AND OVER is available.


CC CKR3
CCR3 Receptors
Antigens, CD193
Receptors, CCR3
CCR3 Receptor
CC Chemokine Receptors 3
CC Chemokine Receptor 3
CD193 Antigens

CCR receptors with specificity for CHEMOKINE CCL11 and a variety of other CC CHEMOKINES. They are expressed at high levels in T-LYMPHOCYTES; EOSINOPHILS; BASOPHILS; and MAST CELLS.


RNA 3' Polyadenylation Signal
AAUAAA RNA Sequence
3' Polyadenylation Signal
RNA 3' Polyadenylation Signals

A hexanucleotide sequence found 10-30 nucleotides upstream of the site of polyandenylation of MRNA.


A class of weak acids with the general formula R-CONHOH.


An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.


Respiratory System Abnormalities
Abnormalities, Respiratory System

Congenital structural abnormalities of the respiratory system.


Neutron Capture Therapy, Boron
Boron Neutron Capture Therapy
Boron-Neutron Capture Therapy
Therapy, Boron Neutron Capture

A technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons.


Neurokinin-3 Receptors
Neurokinin B Receptors
Receptors, Neurokinin-3
NK-3 Receptors
Receptors, Neuromedin K
Receptors, NK-3
Neuromedin K Receptor
Neurokinin-3 Receptor
NK-3 Receptor

A class of cell surface receptors for tachykinins that prefers neurokinin B (neurokinin beta, neuromedin K) over other tachykinins. Neurokinin-3 (NK-3) receptors have been cloned and are members of the G-protein coupled receptor superfamily. They have been found in the central nervous system and in peripheral tissues.


Defective bone formation involving individual bones, singly or in combination.


Broad Thumbs and Great Toes, Characteristic Facies, and Mental Retardation

A chromosomal disorder characterized by MENTAL RETARDATION, broad thumbs, webbing of fingers and toes, beaked nose, short upper lip, pouting lower lip, agenesis of corpus callosum, large foramen magnum, keloid formation, pulmonary stenosis, vertebral anomalies, chest wall anomalies, sleep apnea, and megacolon. The disease has an autosomal dominant pattern of inheritance and is associated with deletions of the short arm of chromosome 16 (16p13.3).


Chorea Acanthocytosis
Chorea Acanthocytosis Syndrome
Neuroacanthocytosis
Choreoacanthocytosis
Chorea-Acanthocytosis
Acanthocytosis with Neurologic Disorder
Levine-Critchley Syndrome

An inherited autosomal disorder that is characterized by neurodegeneration; orofacial and buccal DYSKINESIAS; CHOREA; and thorny-looking red cells (ACANTHOCYTES). This disorder is due to mutations of chorein which is important in protein trafficking and is encoded by Vps13a on chromosome 9q21.


A neoplastic disease of cats frequently associated with feline leukemia virus infection.


Pulmonary Ventilator
Ventilators, Mechanical
Ventilators, Pulmonary
Ventilators
Ventilator, Pulmonary
Respirators
Pulmonary Ventilators

Mechanical devices used to produce or assist pulmonary ventilation.


Seedbank
Seed Bank
Germplasm Bank
Seeds Bank

A repository of seeds maintained under optimal conditions that ensure long term storage, intended for use as a source of replenishment of seed stock or plant genetic material.


Spiritual Healing
Therapies, Spiritual
Spiritual Therapies
Exorcism

Practice of evicting demons or other spiritual entities from a person or area believed to be possessed.


Dental Crowns
Crown, Dental
Crowns, Dental
Crowns
Dental Crown

A prosthetic restoration that reproduces the entire surface anatomy of the visible natural crown of a tooth. It may be partial (covering three or more surfaces of a tooth) or complete (covering all surfaces). It is made of gold or other metal, porcelain, or resin.


A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species.


Bacterial Genes
Bacterial Gene
Genes, Bacterial
Gene, Bacterial

The functional hereditary units of BACTERIA.


Arthrometry, Articular
Goniometry, Articular
Articular Goniometry
Articular Arthrometry

Measurements of joint flexibility (RANGE OF MOTION, ARTICULAR), usually by employing an angle-measuring device (arthrometer). Arthrometry is used to measure ligamentous laxity and stability. It is often used to evaluate the outcome of ANTERIOR CRUCIATE LIGAMENT replacement surgery.


Dental Laminate
Dental Veneer
Dental Veneers
Laminates, Dental
Veneer, Dental
Veneers, Dental
Dental Laminates
Laminate, Dental

The use of a layer of tooth-colored material, usually porcelain or acrylic resin, applied to the surface of natural teeth, crowns, or pontics by fusion, cementation, or mechanical retention.


Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.


Operating Room Information Systems
Information Systems, Operating Room

Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of operating room services and facilities.


Preservation, Biologic
Biological Preservation
Preservation, Biological

The process of protecting various samples of biological material.


Acquired Aphasia with Convulsive Disorder

Aphasia, Acquired, With Convulsive Disorder

Acquired Childhoood Aphasia with Convulsive Disorder

Landau-Kleffner Acquired Epileptiform Aphasia

A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495).


Interview, Psychological
Psychological Interviews
Psychological Interview
Interview, Psychologic
Interviews, Psychological

A directed conversation aimed at eliciting information for psychiatric diagnosis, evaluation, treatment planning, etc. The interview may be conducted by a social worker or psychologist.


The protein components of milk obtained from the whey.


Otitis Media, Secretory
Middle Ear Effusion
Otitis Media, Serous
Otitis Media with Effusion

Inflammation of the middle ear with a clear pale yellow-colored transudate.


Carbon Compounds, Inorganic
Inorganic Carbon Compounds

Inorganic compounds that contain carbon as an integral part of the molecule but are not derived from hydrocarbons.


An arylsulfatase with high specificity towards sulfated steroids. Defects in this enzyme are the cause of ICHTHYOSIS, X-LINKED.


Anion Exchangers (Resins)
Anion Exchange Resins

High-molecular-weight insoluble polymers that contain functional cationic groups capable of undergoing exchange reactions with anions.


Angiotensin I-Converting Enzyme Inhibitors

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.


beta-1 Adrenergic Receptors
Receptors, beta-1 Adrenergic
Receptors, Adrenergic, beta-1
beta 1 Adrenergic Receptor
Adrenergic beta-1 Receptors
Adrenergic Receptor, beta-1
Receptor, Adrenergic, beta-1

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.


Church of Jesus Christ of Latter-day Saints

A group of religious bodies tracing their origin to Joseph Smith in 1830 and accepting the Book of Mormon as divine revelation. (from Merriam-Webster's Collegiate Dictionary, 10th ed)


Herpes Simplex Virus Infection
Herpes Simplex

A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)


Photographic Memory
Memory, Photographic
Eidetic Imagery

A visual image which is recalled in accurate detail. It is a sort of projection of an image on a mental screen.


Pseudomonas Bacteriophages
Pseudomonas Phages

Viruses whose host is Pseudomonas. A frequently encountered Pseudomonas phage is BACTERIOPHAGE PHI 6.


RNA-Directed DNA Polymerase
DNA Polymerase, RNA-Directed
Revertase
RNA-Dependent DNA Polymerase
Reverse Transcriptase
RNA Transcriptase

An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.


A subdiscipline of genetics that studies RADIATION EFFECTS on the components and processes of biological inheritance.


Reverse Transcriptase, Human Immunodeficiency Virus

A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.


Spectral Karyotyping
Karyotyping, Spectral

The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.


Receptor-Associated Protein, Heymann Nephritis

A specific preparation of Heymann nephritis antigenic complex.


Flesh Fly
Sarcophaga
Fleshfly
Flesh Flies
Sarcophagidae

Family of flies in the order DIPTERA, commonly known as flesh flies. They lay their eggs in dead or decaying matter or open wounds.


Inflammatory Bowel Disease, Ulcerative Colitis Type

Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.


Deformity, Congenital Foot
Deformities, Congenital Foot
Foot Deformity, Congenital
Congenital Foot Deformity
Congenital Foot Deformities
Foot Deformities, Congenital

Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.


An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.


Melibiase
alpha-Galactosidase
Beano
alpha-Galactosidases
alpha-D-Galactopyranosidase
alpha-Galactisidase
alpha-D-Galactosidase
alpha-Galactosidase A

An enzyme that catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-galactosides including galactose oligosaccharides, galactomannans, and galactolipids.


Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.


Enzyme Tests, Clinical
Clinical Enzyme Tests

Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status.


Axonal Fasciculation
Neurite Fasciculation
Axon Fasciculation
Axonal Bundling

Process of organizing neighboring AXONS into a bundle or a fascicle during neurite outgrowth mediated by CELL ADHESION MOLECULES.


Sentinel Lymph Node Biopsy
Biopsy, Sentinel Lymph Node
Lymph Node Biopsy, Sentinel

A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The SENTINEL LYMPH NODE is the first lymph node to receive drainage from a neoplasm.


Choroid Hemorrhage
Choroidal Hemorrhage
Hemorrhage, Choroid

Hemorrhage from the vessels of the choroid.


tRNA(Ser)
Transfer RNA, Ser
RNA, Transfer, Ser
Serine-Specific tRNA
tRNASer

A transfer RNA which is specific for carrying serine to sites on the ribosomes in preparation for protein synthesis.


Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).


Peptide Initiation Factor IF-3
Peptide Initiation Factor 3
Prokaryotic Initiation Factor-3
Prokaryotic Peptide Initiation Factor-3
Initiation Factor IF-3
Translation Initiation Factor 3
TIF IF3

A prokaryotic initiation factor that plays a role in recycling of ribosomal subunits for a new round of translational initiation. It binds to 16S RIBOSOMAL RNA and stimulates the dissociation of vacant 70S ribosomes. It may also be involved in the preferential binding of initiator tRNA to the 30S initiation complex.


Encephalitis, Viral
Viral Encephalitis
Encephalomyelitis, Infectious, Viral
Infectious Encephalomyelitis, Viral

Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.


Cytidine Cyclic-3',5'-Monophosphate
Cytidine Cyclic 3,5 Monophosphate
Cytidine Cyclic Monophosphate
Cyclic CMP, Monosodium Salt
Cyclic CMP

A cyclic nucleotide formed from CYTIDINE TRIPHOSPHATE by the action of cytidylate cyclase. It is a potential cyclic nucleotide intracellular mediator of signal transductions.


Hyperbilirubinemia 2
Jaundice, Chronic Idiopathic
Dubin-Johnson Syndrome
Hyperbilirubinemia II

A benign, autosomally recessive inherited hyperbilirubinemia characterized by the presence of a dark pigment in the centrilobular region of the liver cells. There is a functional defect in biliary excretion of bilirubin, cholephilic dyes, and porphyrins. Affected persons may be asymptomatic or have vague constitutional or gastrointestinal symptoms. The liver may be slightly enlarged, and oral and intravenous cholangiography fails to visualize the biliary tract.


Glutamate Carboxy-Lyase
Glutamate Decarboxylase
Glutamic Acid Decarboxylase

A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.


A high-affinity, ATP-binding, co-transporter for CARNITINE that is highly expressed in kidney, skeletal muscle, heart, and placental tissues. It transports one sodium ion with one carnitine molecule. It has a lower affinity for other organic cations and transports them independently of sodium. Mutations in the SLC22A5 gene are associated with systemic carnitine deficiency.


Anisoylated Plasminogen-Streptokinase Activator Complex

An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.


Peritoneal Absorption
Intraperitoneal Absorption

Uptake of substances from the PERITONEAL CAVITY.


Monocyte Chemotactic and Activating Factor

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.


Personal satisfaction relative to the work situation.


Physicians specializing in physiological and pathological aspects of aging and the aged, including the clinical problems of senescence and senility.


Pyrocatechols o-Dihydroxybenzenes ortho-Dihydroxybenzenes Catechols

A group of 1,2-benzenediols that contain the general formula R-C6H5O2.


Pregnancy, High-Risk
High-Risk Pregnancy

Pregnancy in which the mother and/or FETUS are at greater than normal risk of MORBIDITY or MORTALITY. Causes include inadequate PRENATAL CARE, previous obstetrical history (ABORTION, SPONTANEOUS), pre-existing maternal disease, pregnancy-induced disease (GESTATIONAL HYPERTENSION), and MULTIPLE PREGNANCY, as well as advanced maternal age above 35.