Ventilation-Perfusion Scintigraphy
Pulmonary Ventilation Perfusion Scans
Lung Ventilation Perfusion Scans
Ventilation-Perfusion Scan
Lung VQ Scan
Ventilation Perfusion Lung Scan
VQ Lung Scan
V-Q Scintigraphy

A two-part radionuclide imaging that measures VENTILATION-PERFUSION RATIO of the lungs often used to investigate PULMONARY EMBOLISM. Image acquisitions may be performed using various combinations of gamma camera, PET and SPECT scanning techniques.


3' UTR
3' Untranslated Region
3'UTR
3' Untranslated Regions

The sequence at the 3' end of messenger RNA that does not code for product. This region contains transcription and translation regulating sequences.


Bluetongue virus
Ovine Catarrhal Fever Virus
Blue Tongue Virus

The type species of ORBIVIRUS causing a serious disease in sheep, especially lambs. It may also infect wild ruminants and other domestic animals.


A group (or phylum) of flagellated, anaerobic EUKARYOTES that are endosymbionts of animals. They lack mitochondria but contain small energy-producing hydrogenosomes. The group is comprised of two major classes: HYPERMASTIGIA and TRICHOMONADIDA.


RNA-Directed RNA Polymerase
RNA Replicase
RNA-Dependent RNA Polymerase

An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)


Armed Conflicts and Warfare
Warfare and Armed Conflicts

Engaging in any type of conflict including war or military conflict against another nation or organized group.


Nutritional Disorders
Nutrition Disorders

Disorders caused by nutritional imbalance, either overnutrition or undernutrition.


Culture Media, Serum-Free
Low-Serum Media
Protein-Free Media
Serum-Free Media

CULTURE MEDIA free of serum proteins but including the minimal essential substances required for cell growth. This type of medium avoids the presence of extraneous substances that may affect cell proliferation or unwanted activation of cells.


A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.


The function of opposing or restraining the excitation of neurons or their target excitable cells.


A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).


Alkylated DNA Repair Protein Alkb Homolog 8

S-Adenosyl-L-Methionine-Dependent tRNA Methyltransferase ABH8

Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH8

A dioxygenase and alkylation repair homolog that catalyzes the methylation of 5-carboxymethyl URIDINE to 5-methylcarboxymethyl uridine at the wobble position of the ANTICODON loop in TRANSFER RNA (tRNA) via its methyltransferase domain. It has a preference for tRNA (ARGININE) and tRNA (GLUTAMATE), and does not bind tRNA (LYSINE).


Dihomogammalinolenic Acid
8,11,14 Eicosatrienoic Acid
8,11,14-Eicosatrienoic Acid
Homo-gamma Linolenic Acid
Ro 12-1989
Dihomo-gamma-Linolenic Acid

A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.


A plant genus of the family ARACEAE that may be confused with other ARACEAE having similar common names.


A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.


EAAT-4 Excitatory Amino Acid Transporter

A glutamate plasma membrane transporter protein that is primarily expressed in cerebellar PURKINJE CELLS on postsynaptic DENDRITIC SPINES.


CD20 Antigens
Antigens, CD20
CD20 Antigen

Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.


Roxarsone
3-Nitro-4-Hydroxyphenylarsonic Acid
3-Nitro-10

An arsenic derivative which has anticoccidial action and promotes growth in animals.


Neonatal Diseases
Infant, Newborn, Diseases

Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.


Influenza A Virus, H9N2 Subtype
H9N2 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 9 and neuraminidase 2. The H9N2 subtype usually infects domestic birds (POULTRY) but there have been some human infections reported.


Trematode Infections
Metagonimiasis
Infections, Trematode
Fasciolopsiasis

Infections caused by infestation with worms of the class Trematoda.


5-HT1 Receptor
Receptors, Serotonin, 5-HT1
Serotonin 5-HT1 Receptors
Serotonin Receptors, 5-HT1
5-HT1 Receptors
Serotonin, 5-HT1 Receptors
Serotonin 5-HT1 Receptor

A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.


Continuing Education
Education, Continuing

Educational programs designed to inform individuals of recent advances in their particular field of interest. They do not lead to any formal advanced standing.


3-Keto-Erythromycins
Ketolides
Erythromycins, 3-Keto

Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.


Food Packaging
Food Containers
Packaging, Food

Containers, packaging, and packaging materials for processed and raw foods and beverages. It includes packaging intended to be used for storage and also used for preparation of foods such as microwave food containers versus COOKING AND EATING UTENSILS. Packaging materials may be intended for food contact or designated non-contact, for example, shipping containers. FOOD LABELING is also available.


Fetishism, Psychiatric
Fetishism (Psychiatric)

A condition in which inanimate objects are utilized as a preferred or exclusive method of stimulating erotic arousal.


Chromosomes, Artificial, Yeast
Artificial Chromosomes, Yeast
YACs (Chromosomes)
Yeast Artificial Chromosomes
YAC (Chromosome)
Chromosomes, Yeast Artificial

Chromosomes in which fragments of exogenous DNA ranging in length up to several hundred kilobase pairs have been cloned into yeast through ligation to vector sequences. These artificial chromosomes are used extensively in molecular biology for the construction of comprehensive genomic libraries of higher organisms.


AMP Pyrophosphorylase
Transphosphoribosidase
Adenine Phosphoribosyltransferase
APRTase

An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 2.4.2.7.


Testosterone-Repressed Prostate Message-2 Protein

A highly conserved heterodimeric glycoprotein that is differentially expressed during many severe physiological disturbance states such as CANCER; APOPTOSIS; and various NEUROLOGICAL DISORDERS. Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE.


Power Sources, Electric
Power Sources
Electric Power Supplies
Power Supplies, Electric
Electric Power Sources
Power Supplies

Devices that control the supply of electric current for running electrical equipment.


Serine Peptidase Inhibitor, Kazal-Type 1

Pancreatic Trypsin Secretory Inhibitor, Kazal

Pancreatic Secretory Trypsin Inhibitor, Kazal

A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.


An enzyme which catalyzes the release of BIOTIN from biocytin. In human, defects in the enzyme are the cause of the organic acidemia MULTIPLE CARBOXYLASE DEFICIENCY or BIOTINIDASE DEFICIENCY.


A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)


Health Knowledge, Attitudes, Practice
Knowledge, Attitudes, Practice

Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).


Gut Absorption
Gastrointestinal Absorption

Uptake of substances via the GASTROINTESTINAL TRACT.


Myocardial Remodeling, Atrial
Atrial Remodeling
Cardiac Remodeling, Atrial
Electrical Remodeling
Atrium Remodeling

Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE.


Epidermolytic Palmoplantar Keratoderma Vorner Type

EPPK (Epidermolytic Palmoplantar Keratoderma)

An autosomal dominant hereditary skin disease characterized by epidermolytic hyperkeratosis that is strictly confined to the palms and soles. It has been associated with mutations in the gene that codes for KERATIN-9.


Ubiquitin-Activating Enzyme E1-like Protein

Ubiquitin-Like Modifier-Activating Enzyme ATG7

An autophagy related protein  that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.


ATP-Dependent Organic Anion Transporters

Organic Anion Transporters, ATP-Dependent

A subclass of ORGANIC ANION TRANSPORTERS whose transport of organic anions is linked directly to the hydrolysis of ATP. The subclass includes those ATP-BINDING CASSETTE TRANSPORTERS that transport organic ions.


A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.


An organism of the vegetable kingdom suitable by nature for use as a food, especially by human beings. Not all parts of any given plant are edible but all parts of edible plants have been known to figure as raw or cooked food: leaves, roots, tubers, stems, seeds, buds, fruits, and flowers. The most commonly edible parts of plants are FRUIT, usually sweet, fleshy, and succulent. Most edible plants are commonly cultivated for their nutritional value and are referred to as VEGETABLES.


Silent Mating Type Information Regulation 2 Homolog 1

A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.


An enzyme that catalyzes the oxidation of succinate semialdehyde to SUCCINIC ACID. It plays a role in the metabolism of GLUTAMATE; TYROSINE; and butanoate.


Pregnancy, Interstitial
Interstitial Pregnancy

A type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the portion of the FALLOPIAN TUBE that traverses the muscular wall of the uterus.


Oncogene Protein E7, Papillomavirus
Papillomavirus E7 Proteins
E7 Oncogene Proteins

ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.


Antinematodal Drugs
Antinematodals
Nematocides
Antinematodal Agents

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.


Dose-Response Relationship, Drug
Dose Response Relationship, Drug

The relationship between the dose of an administered drug and the response of the organism to the drug.


Manual Lymphatic Drainage
Manual Lymph Drainage
Lymphatic Drainage Massage

The application of massage to control EDEMA and improve circulation by manually moving excess lymph out of a tissue.


Clostridium difficile Infection
Clostridium sordellii Infection
Clostridium Infections
Infections, Clostridium
Clostridium perfringens Infections
Clostridium perfringens Food Poisoning

Infections with bacteria of the genus CLOSTRIDIUM.


Silo Fillers Disease
Silo Fillers' Disease
Silo Filler Disease
Silo Filler's Disease

A form of alveolitis or PNEUMONITIS caused by hypersensitivity to high level of inhaled nitrogen oxides, decomposition products of silage.


Congenital Heart Defect
Abnormality, Heart
Heart, Malformation Of
Heart Defect, Congenital
Congenital Heart Defects
Defects, Congenital Heart
Heart Defects, Congenital
Heart Abnormalities

Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.


Chronologic Fetal Maturity
Gestational Age
Maturity, Chronologic Fetal
Fetal Age
Fetal Maturity, Chronologic

The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.


Anoplura
Sucking Louse
Linognathus
Haematopinus
Polyplax
Solenopotes
Hoplopleura
Sucking Lice

An order of insects comprising the sucking lice, which are blood-sucking ectoparasites of mammals. Recognized families include: Echinphthiriidae, Haematopinidae, and Pediculidae. The latter contains the medically important genera affecting humans: PEDICULUS and PHTHIRUS.


Gastroenteritis Virus, Porcine Transmissible

Porcine Transmissible Gastroenteritis Virus

Transmissible Gastroenteritis Virus, Swine

A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.


Air Radiography
Radiography, Air
Contrast Radiography, Negative
Radiography, Insufflation
Negative Contrast Radiography
Insufflation Radiography
Pneumoradiography
Radiography, Negative Contrast

Radiography using air, oxygen, or some other gas as a contrast medium.


Subacute Toxicity Tests
Toxicity Tests, Subacute

Experiments designed to determine the potential toxic effects of a short-term (a few weeks) exposure to a chemical or chemicals.


Calymmatobacterium granulomatis
Calymmatobacterium
Donovania

A genus of bacteria causing GRANULOMA INGUINALE and other granulomatous lesions.


Nephro-ureterectomy Ureteronephrectomy Nephroureterectomy Heminephroureterectomy

Surgical removal of a kidney and adjoining ureter.


5-HT2A Receptor
5-HT(2A) Receptor
Receptor, Serotonin, 5-HT2A
Serotonin 2A Receptors
Receptor, Serotonin 2A
Serotonin 2A Receptor

A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.


Endothelin Antagonists
Endothelin Receptor Antagonists

Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN RECECPTORS.


Professional Ethics
Ethics, Professional

The principles of proper conduct concerning the rights and duties of the professional, relations with patients or consumers and fellow practitioners, as well as actions of the professional and interpersonal relations with patient or consumer families. (From Stedman, 25th ed)


GWA Study
Whole Genome Association Analysis
Whole Genome Association Study
Genome Wide Association Studies
Genome Wide Association Study
Genome Wide Association Scan
Genome Wide Association Analysis
Genome-Wide Association Study

An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.


Borderline Tuberculoid
Leprosy, Paucibacillary
Indeterminate Tuberculoid
Paucibacillary Leprosy

A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with paucibacillary leprosy have fewer than six skin lesions with no causative agent MYCOBACTERIUM LEPRAE on any slit-skin smear testing. Paucibacillary leprosy encompasses indeterminate, borderline tuberculoid, and tuberculoid leprosy.


Nucleus Medialis Dorsalis
Medial Dorsal Nucleus
Medial Thalamic Nucleus
Dorsomedial Nucleus
Medial Dorsal Thalamic Nucleus
Medial Thalamic Nuclei
Dorsomedial Thalamic Nucleus
Nucleus Dorsomedialis Thalami
Mediodorsal Thalamic Nucleus
Mediodorsal Nucleus
Dorsal Medial Nucleus

The largest of the medial nuclei of the thalamus. It makes extensive connections with most of the other thalamic nuclei.


Dendritic Cells, Follicular
Follicular Dendritic Cells
Dendritic Reticulum Cells, Follicular

Non-hematopoietic cells, with extensive dendritic processes, found in the primary and secondary follicles of lymphoid tissue (the B cell zones). They are different from conventional DENDRITIC CELLS associated with T-CELLS. They are derived from MESENCHYMAL STEM CELLS and are negative for class II MHC antigen and do not process or present antigen like the conventional dendritic cells do. Instead, follicular dendritic cells have FC RECEPTORS and C3B RECEPTORS that hold antigen in the form of ANTIGEN-ANTIBODY COMPLEXES on their surfaces for long periods for recognition by B-CELLS.


Spectrophotometry, Infrared
Infrared Spectrophotometry

Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Evoked Potentials, Somatosensory
Somatosensory Evoked Potentials

The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM.


Bunaphtine Bunaphtide Bunaftide Bunaftine

N-Butyl-N-(2-(diethylamino)ethyl)-1-naphthamide. A proposed antiarrhythmic that prolongs myocardial refractory period and stabilizes cell membranes.


Renal NAD(P)H Oxidase
Nox4 Protein
NADPH Oxidase 4
Renox NAD(P)H Oxidase

An NADPH oxidase that is strongly expressed in the kidney. It forms a complex with CYBA-P22PHOX and produces intracellular SUPEROXIDES that may regulate cellular signaling in APOPTOSIS; BONE RESORPTION; and NF-KAPPA B activation.


Leukemia, Myeloid, Philadelphia Positive

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.


At low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either before or at the site of its inhibitory activity.


Muscle Diastasis
Diastasis, Muscle
Myodiastasis


Infectious Diseases
Communicable Diseases

An illness caused by an infectious agent or its toxins that occurs through the direct or indirect transmission of the infectious agent or its products from an infected individual or via an animal, vector or the inanimate environment to a susceptible animal or human host.


Care Givers
Carers
Caregivers
Family Caregivers
Spouse Caregivers

Persons who provide care to those who need supervision or assistance in illness or disability. They may provide the care in the home, in a hospital, or in an institution. Although caregivers include trained medical, nursing, and other health personnel, the concept also refers to parents, spouses, or other family members, friends, members of the clergy, teachers, social workers, fellow patients.


HLA-DP
HLA-PL
HLA-SB Antigens
HLA-SB
HLA-DP Antigens
HLA-PL Antigens

A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.


Displacement, Psychology
Displacement, Psychological
Psychological Displacement

The process by which an emotional or behavioral response that is appropriate for one situation appears in another situation for which it is inappropriate.


Cyclin-Dependent Kinase Inhibitor p19
INK4D Protein
Cyclin-Dependent Kinase Inhibitor 2D
p19INK4D Protein
CDKN2D Protein

An INK4 cyclin-dependent kinase inhibitor containing five ANKYRIN REPEATS. Aberrant expression of this protein has been associated with TESTICULAR CANCER.


Brown Algae
Phaeophyta
Phaeophyceae
Algae, Brown

A division of predominantly marine EUKARYOTA, commonly known as brown algae, having CHROMATOPHORES containing carotenoid PIGMENTS, BIOLOGICAL. ALGINATES and phlorotannins occur widely in all major orders. They are considered the most highly evolved algae because of their well-developed multicellular organization and structural complexity.


Tandem Repeats
Tandem Repeat
Direct Tandem Repeats
Tandem Repeat Sequences

Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (INVERTED TANDEM REPEATS).


An order of slender, flexuous, helically coiled bacteria, with one or more complete turns in the helix.


A genus of gram-negative, anaerobic, rod-shaped bacteria found in cavities of humans and other animals. No endospores are formed. Some species are pathogenic and occur in various purulent or gangrenous infections.


Surgical Procedures, Robotic
Robot-Enhanced Surgery
Robotic Surgical Procedures
Robot-Enhanced Procedures

Surgical procedures performed using a computer that remotely controls surgical instruments attached to mechanical arms designed to perform the tasks of the surgeon.


Disomy, Uniparental
Uniparental Disomy
Uniparental Heterodisomy
Uniparental Isodisomy

The presence in a cell of a chromosome pair that is composed of duplicates of one parental chromosome.


VASODILATION that is mediated via the ENDOTHELIUM-DEPENDENT RELAXING FACTORS or their processes.


WHITE MATTER pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the WHITE MATTER and the BRAINSTEM. It consists of three distinct parts: an anterior limb, posterior limb, and genu.


Anacardic Acids
Salicylic Acids, 6-Alkyl

A group of 6-alkyl SALICYLIC ACIDS that are found in ANACARDIUM and known for causing CONTACT DERMATITIS.


Germline Mutation
Mutation, Germ-Line
Germ-Line Mutation

Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.


Gui Zhi
Cassia, Chinese
Cinnamomum aromaticum
Chinese Cinnamon
Cassia Tree
Cinnamomum cassia

A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).


Granular Cell Tumor
Granular Cell Myoblastoma
Myoblastoma, Granular Cell

Unusual tumor affecting any site of the body, but most often encountered in the head and neck. Considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. It affects women more often than men. When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.


Infections, Mycoplasmatales
Mycoplasmatales Infections

Infections with bacteria of the order MYCOPLASMATALES.


Histamine H3 Receptor
H3 Receptors
Receptors, Histamine H3
Histamine H3 Receptors

A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)


ras-GAP
ras-GAPs
ras GTPase-Activating Proteins

PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.


Viridans Streptococci
Streptococcus Viridans Group
Streptococcus viridans

A large heterogeneous group of mostly alpha-hemolytic streptococci. They colonize the respiratory tract at birth and generally have a low degree of pathogenicity. This group of species includes STREPTOCOCCUS MITIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS SANGUIS; STREPTOCOCCUS SOBRINUS; and the STREPTOCOCCUS MILLERI GROUP. The latter are often beta-hemolytic and commonly produce invasive pyogenic infections including brain and abdominal abscesses.


Cubital Tunnel Syndrome
Ulnar Nerve Compression, Cubital Tunnel
Ulnar Nerve Entrapment, Elbow

Compression of the ULNAR NERVE in the cubital tunnel, which is formed by the two heads of the flexor carpi ulnaris muscle, humeral-ulnar aponeurosis, and medial ligaments of the elbow. This condition may follow trauma or occur in association with processes which produce nerve enlargement or narrowing of the canal. Manifestations include elbow pain and PARESTHESIA radiating distally, weakness of ulnar innervated intrinsic hand muscles, and loss of sensation over the hypothenar region, fifth finger, and ulnar aspect of the ring finger. (Joynt, Clinical Neurology, 1995, Ch51, p43)


CD4 Immunoadhesins
CD4-IgG
Immunoadhesins, CD4

Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.


Metals with low specific gravity, typically smaller than 5, characterized by a single valence (1, 2, or 3), a simple spectrum, strong electromotive force (positive), and colorless compounds. (From Grant & Hackh's Chemical Dictionary, 5th ed)


Body Image Disorders
Body Image Disfunction
Body Dysmorphic Disorders

Preoccupations with appearance or self-image causing significant distress or impairment in important areas of functioning.


Matricellular CCN Proteins
CYR61 CTGF NOV Matricellular Proteins
CCN Family Proteins
CCN Intercellular Signaling Proteins

A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.


CCAAT Sequence-Specific DNA-Binding Proteins

A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.


Interstitial Cells, Testicular
Leydig Cells
Testicular Interstitial Cells

Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.


Father-Child Relationship
Father-Child Relations

Interaction between the father and the child.


Kraurosis Penis
Balanitis Xerotica Obliterans

An atrophic and sclerotic condition of the head of the PENIS, glans penis. Sometimes it leads to stenosis and occasionally obliteration of the external meatal orifice.


Alu-Like Repetitive Sequence
Alu Repetitive Sequences
Alu Elements
Alu Family

The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). It is derived from the 7SL RNA component of the SIGNAL RECOGNITION PARTICLE and contains an RNA polymerase III promoter. Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases.


beta-Isopropylmalate Dehydrogenase
3-Isopropylmalate Dehydrogenase
beta-IPM Dehydrogenase

An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. It is involved in the biosynthesis of VALINE; LEUCINE; and ISOLEUCINE.


Myofascial Pain Syndrome, Diffuse
Rheumatism, Muscular
Fibromyalgia-Fibromyositis Syndrome
Fibromyalgia, Secondary
Fibromyositis-Fibromyalgia Syndrome
Diffuse Myofascial Pain Syndrome
Fibromyalgia
Fibrositis
Fibromyalgia, Primary

A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)


An extra-embryonic membranous sac derived from the YOLK SAC of REPTILES; BIRDS; and MAMMALS. It lies between two other extra-embryonic membranes, the AMNION and the CHORION. The allantois serves to store urinary wastes and mediate exchange of gas and nutrients for the developing embryo.


Recycling, Equipment
Product Recycling
Equipment Reusability
Equipment Reuse

Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.


Inflammation of the DENTAL PULP, usually due to bacterial infection in dental caries, tooth fracture, or other conditions causing exposure of the pulp to bacterial invasion. Chemical irritants, thermal factors, hyperemic changes, and other factors may also cause pulpitis.


Estradiol Receptor alpha
ERalpha
Estrogen Receptors alpha
Receptor alpha, Estrogen
Estrogen Receptor 1
Estrogen Receptor alpha

One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.


PII Nitrogen Regulatory Proteins
P(II) Nitrogen Regulatory Proteins
Nitrogen Regulatory Proteins
Nitrogen-Regulated Response Proteins

A family of signal transducing adaptor proteins that control the METABOLISM of NITROGEN. They are primarily found in prokaryotes.


Retinal Photoreceptor Cell Outer Segment

The light sensitive outer portion of a retinal rod or a cone photoreceptor cell. The outer segment contains a stack of disk membranes laden with photoreceptive pigments (RETINAL PIGMENTS). The outer segment is connected to the inner segment by a PHOTORECEPTOR CONNECTING CILIUM.


Psychology, Developmental
Developmental Psychology

Field of study concerned with age-related changes in BEHAVIOR that occur in human beings over the course of life, from birth to death. It includes all aspects of human growth, including emotional, intellectual, social, perceptual and personality development.


Leontideus
Leontopithecus
Tamarin, Lion
Black Lion Tamarin
Tamarin, Golden

The genus of lion tamarins in the subfamily CALLITRICHINAE. The common name refers to the mane on the shoulders.


Meningococcus, Serogroup B
Neisseria meningitidis, Serogroup B
Meningococci, Serogroup B

Strains of Neisseria meningitidis which are the most common ones causing infections or disease in infants. Serogroup B strains are isolated most frequently in sporadic cases, and are less common in outbreaks and epidemics.


Problem-Oriented Medical Records
Medical Records, Problem-Oriented
Medical Record, Problem-Oriented
Record, Problem-Oriented Medical
Records, Problem-Oriented Medical
Medical Records, Problem Oriented

A system of record keeping in which a list of the patient's problems is made and all history, physical findings, laboratory data, etc. pertinent to each problem are placed under that heading.


Pepsinogen C
Pepsinogen II
Progastricsin

This is one of the 2 related pepsinogen systems in humans. It is found in prostate and seminal fluid whereas PEPSINOGEN A is not.


A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.


The processes whereby the internal environment of an organism tends to remain balanced and stable.


Autophagy-Related Protein 12
ATG12 Protein
Ubiquitin-Like Protein ATG12

A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.


Group V Secretory Phospholipase A2
Phospholipases A2, Group V
Group V Phospholipases A2
Group V sPLA2

A subcategory of secreted phospholipases A2 that contains both a negatively charged carboxy-terminal segment and interfacial-binding region specific for PHOSPHATIDYL CHOLINE-containing membranes. This enzyme group may play a role in the release of ARACHIDONIC ACID from phospholipid membranes.


Thyroxine-Binding Protein
Thyroxine-Binding Proteins
Thyroxine Transport Protein

Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system.


Pond Lily, Yellow
Lily, Yellow Pond
Nuphar

A plant genus of the family NYMPHAEACEAE. Members contain sesquiterpene thioalkaloids.


Jelly-like connective tissue of the UMBILICAL CORD that contains MESENCHYMAL STEM CELLS.


A pre-emergence, selective herbicide for the control of wild oats in various crops.


Tumor Necrosis Factor Receptor Superfamily, Member 7

A member of the tumor necrosis factor receptor superfamily found on most T-LYMPHOCYTES. Activation of the receptor by CD70 ANTIGEN results in the increased proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Emotional, nutritional, financial, or physical maltreatment, exploitation, or abandonment of the older person generally by family members or by institutional personnel.


The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.


Papillotomy, Endoscopic
Endoscopic Biliary Sphincterotomy
Sphincterotomy, Endoscopic
Endoscopic Sphincterotomy
Endoscopic Papillotomy

Incision of SPHINCTER OF ODDI or VATER'S AMPULLA performed by inserting a sphincterotome through DUODENOSCOPE often following or performed during ERCP (ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY).


IUD Migration
Intrauterine Device Migration

The shifting in position or location of an INTRAUTERINE DEVICE from its original placement.


Systems, Communication Hospital
Hospital Communication Systems
Communication Systems, Hospital
Hospital Communication System
System, Hospital Communication
Communication System, Hospital

The transmission of messages to staff and patients within a hospital.


Histological Types of Neoplasms
Neoplasms by Histological Type
Neoplasms by Histologic Type
Histological Type of Neoplasm

A collective term for the various histological types of NEOPLASMS. It is more likely to be used by searchers than by indexers and catalogers.


Muscle, Voluntary
Gastrocnemius Muscle
Skeletal Muscle
Anterior Tibial Muscle
Plantaris Muscle
Soleus Muscle
Muscle, Skeletal

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.


Hydrocolloid Dressing
Bandages, Hydrocolloid
Duoderm
Bandages, Hydrogel

Dressings comprised of a self-adhesive matrix to which hydrophilic absorbent particles are embedded. The particles consist of CELLULOSE derivatives; calcium ALGINATES; PECTINS; or GELS. The utility is based on providing a moist environment for WOUND HEALING.


Tumor Necrosis Factor Receptor Superfamily, Member 11a

Receptors, Tumor Necrosis Factor, Member 11a

Receptor Activator of Nuclear Factor-kappaB

Receptor Activator of Nuclear Factor-kappa B

A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


epsilon-Chain Immunoglobulins
Immunoglobulins, epsilon-Chain
Ig epsilon Chains
epsilon-Immunoglobulin Heavy Chain
Immunoglobulin epsilon-Chain
Immunoglobulin epsilon-Chains
epsilon-Immunoglobulin Heavy Chains

The class of heavy chains found in IMMUNOGLOBULIN E. They have a molecular weight of approximately 72 kDa and they contain about 550 amino acid residues arranged in five domains and about three times more carbohydrate than the heavy chains of IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; and IMMUNOGLOBULIN G.


Oncogene Proteins, Viral
Viral Oncogene Proteins
v-onc Proteins
Viral Transforming Proteins

Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.


Spinal Cord Compression, Extramedullary
Spinal Cord Compression
Conus Medullaris Syndrome
Extramedullary Spinal Cord Compression
Myelopathy, Compressive

Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.


Postural Orthostatic Tachycardia Syndrome

A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.


Porphyria, Hepatoerythropoietic
Porphyria, Erythrohepatic
Hepatoerythropoietic Porphyria

An autosomal recessive cutaneous porphyria that is due to a deficiency of UROPORPHYRINOGEN DECARBOXYLASE in both the LIVER and the BONE MARROW. Similar to PORPHYRIA CUTANEA TARDA, this disorder is caused by defects in the fifth enzyme in the 8-enzyme biosynthetic pathway of HEME, but is a homozygous enzyme deficiency with less than 10% of the normal enzyme activity. Cutaneous lesions are severe and mutilating.


GAP Protein
GTPase-Activating Protein
GAP Proteins
GTPase-Activating Proteins

Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.


Hazard Analysis and Critical Control Points

A system of safety management (abbreviated HACCP) applied mainly to the food industry. It involves the analysis and control of biological, chemical, and physical hazards, from raw material production, procurement and handling, to manufacturing, distribution and consumption of finished products.


Commercial Catalogs as Topic
Catalogs, Commercial as Topic

Works about lists of merchandise for sale.


beta-Hexosaminidase beta Chain
beta-N-Acetylhexosaminidase beta Chain
Hexosaminidase B, beta Chain
Hexosaminidase A, beta Chain

The beta subunit of hexosaminidase A and hexosamininidase B. Mutations in the gene that encodes this protein are linked to SANDHOFF DISEASE and can result in loss of both hexosaminidase A activity and hexosaminidase B activity.


Johne Disease
Paratuberculosis
Johne's Disease

A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.


Employees
Employee
Group, Occupational
Occupational Groups
Workers
Occupational Group
Worker
Groups, Occupational
Personnel

Members of the various professions (e.g., PHYSICIANS) or occupations (e.g., POLICE).


Serratia Infections
Infections, Serratia

Infections with bacteria of the genus SERRATIA.


Rehabilitation Nursing
Nursing, Rehabilitation

A nursing specialty involved in the diagnosis and treatment of human responses of individuals and groups to actual or potential health problems with the characteristics of altered functional ability and altered life-style.


Postural Drainage
Postural Drainage, Pulmonary
Drainage, Respiratory, Postural
Respiratory Drainage, Postural
Drainage, Postural

A rehabilitation therapy for removal of copious mucus secretion from the lung of patients with diseases such as CHRONIC BRONCHITIS; BRONCHIECTASIS; PULMONARY ABSCESS; or CYSTIC FIBROSIS. The patient's head is placed in a downward incline (so the TRACHEA is inferior to the affected area) for 15- to 20-minute sessions.


Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.


Multicomponent ribonucleoprotein structures found in the CYTOPLASM of all cells, and in MITOCHONDRIA, and PLASTIDS. They function in PROTEIN BIOSYNTHESIS via GENETIC TRANSLATION.


A chemically and thermodynamically stable derivative of BENZIDINE.


Infant, Extremely Premature
Extremely Preterm Infants
Extremely Premature Infants

A human infant born before 28 weeks of GESTATION.


Cytochrome P450 Family 3
CYP3 Family
CYP3 Enzymes

A cytochrome P450 enzyme family that includes members with critical functions in the metabolism of drugs and SEX HORMONES.


A pea-shaped carpal bone that actually sits in the tendon of the flexor carpi ulnaris muscle.


Sudden death from overwork, most often as a result of acute CARDIOVASCULAR STROKE.


Receptors, ANF
Atrial Natriuretic Peptides Receptor
Receptors, Atrial Natriuretic Factor
Atrial Natriuretic Peptides Receptors
Receptors, Atrial Natriuretic Peptides
Atrial Natriuretic Factor Receptor
ANP Receptors
Atriopeptin Receptors
Atrial Natriuretic Factor Receptors
ANF Receptors
Receptors, ANP
Receptors, Atriopeptin

Cell surface proteins that bind ATRIAL NATRIURETIC FACTOR with high affinity and trigger intracellular changes influencing the behavior of cells. They contain intrinsic guanylyl cyclase activity.


Leber's Optic Atrophy
Leber's Optic Neuropathy
Optic Atrophy, Leber Type
Leber Hereditary Optic Neuropathy
Leber Hereditary Optic Atrophy
Leber's Disease
Optic Atrophy, Hereditary, Leber
Leber Optic Atrophy and Dystonia
Leber's Hereditary Optic Atrophy
Optic Atrophy, Leber, Hereditary
Leber Optic Atrophy
Hereditary Optic Neuroretinopathy
Leber's Hereditary Optic Neuropathy

A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))


A specialty concerned with the diagnosis and treatment of foot disorders and injuries and anatomic defects of the foot.


Human immunodeficiency virus 1
HIV-1
Immunodeficiency Virus Type 1, Human
Human Immunodeficiency Virus Type 1
HIV-I

The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.


Serine Peptidase Inhibitors, Kazal Type
SPINK Family Proteins
Serine Protease Inhibitors, Kazal Type

A family of serine peptidase inhibitors that occur in animals, some single-cell eukaryotes, and higher plants. They contain variable numbers of KAZAL MOTIFS and inhibit SERINE ENDOPEPTIDASES such as ACROSIN and TRYPSIN.


Pin, Dental
Peg, Dental
Pegs, Dental
Dental Pegs
Dental Pins
Dental Pin
Dental Peg
Pins, Dental

Small cylindrical pieces of metal used to enhance retention.


Plants of the division Rhodophyta, commonly known as red algae, in which the red pigment (PHYCOERYTHRIN) predominates. However, if this pigment is destroyed, the algae can appear purple, brown, green, or yellow. Two important substances found in the cell walls of red algae are AGAR and CARRAGEENAN. Some rhodophyta are notable SEAWEED (macroalgae).


Compounds with a core of fused benzo-pyran rings.


Postal Service
Mail-Order
Mail Distribution
Service, Postal
Mail

The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.


Phosphoric Monoester Hydrolases
Phosphohydrolases
Phosphatases
Phosphomonoesterases

A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate.


Skin Transplantation
Transplantation, Skin
Dermatoplasty
Grafting, Skin

The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.


Descemet Membrane
Lamina Elastica Posterior
Descemet's Membrane

A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.


Biologic Psychiatry
Biological Psychiatry
Psychiatry, Biological

An interdisciplinary science concerned with studies of the biological bases of behavior - biochemical, genetic, physiological, and neurological - and applying these to the understanding and treatment of mental illness.


Substances elaborated by viruses that have antigenic activity.


Fetal Therapies
Fetal Therapy
Therapy, Fetal

Prenatal interventions to correct fetal anomalies or treat FETAL DISEASES in utero. Fetal therapies include several major areas, such as open surgery; FETOSCOPY; pharmacological therapy; INTRAUTERINE TRANSFUSION; STEM CELL TRANSPLANTATION; and GENETIC THERAPY.


Dentin-Bonding Agents
Bonding Agents, Dentin

Cements that act through infiltration and polymerization within the dentinal matrix and are used for dental restoration. They can be adhesive resins themselves, adhesion-promoting monomers, or polymerization initiators that act in concert with other agents to form a dentin-bonding system.


Services, Outsourced
Outsourcing
Outsourced Services

Organizational activities previously performed internally that are provided by external agents.


Chemokine CCL21
SLC Chemokine
CCL21 Chemokine
Exodus-2 Chemokine
Secondary Lymphoid-Tissue Chemokine
6Ckine
Thymus-Derived Chemotactic Agent 4

A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.


A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.


HLA Class I Histocompatibility Antigen, A-11 alpha Chain

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family.


SHOX Protein
PHOG Protein
Short Stature Homeobox Protein
SHOXY Protein
GCFX Protein

A homeodomain protein that is highly expressed in the nuclei of skeletal muscle, bone marrow, and osteogenic cells and has critical roles in growth and development. Its gene resides within PSEUDOAUTOSOMAL REGION 1 of X and Y chromosomes and mutations are associated with several growth disorders including LERI-WEIL SYNDROME; LANGER MESOMELIC DYSPLASIA; and SHORT STATURE, IDIOPATHIC, X-LINKED.


Contact Lenses, Extended-Wear
Contact Lens, Extended-Wear

Hydrophilic contact lenses worn for an extended period or permanently.


Advice and support given to individuals to help them understand and resolve their sexual adjustment problems. It excludes treatment for PSYCHOSEXUAL DISORDERS or PSYCHOSEXUAL DYSFUNCTION.


CD66e Antigen
Carcinoembryonic Antigen
Antigen, CD66e
Antigens, CD66e

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.


Education, Vocational
Vocational Training
Vocational Education

EDUCATION that prepares the student for a specific trade such as plumbing, masonry, and carpentry.


Glaucoma, Angle-Closure
Glaucoma, Uncompensated
Glaucoma, Uncompensative
Glaucoma, Narrow-Angle
Glaucoma, Closed-Angle
Glaucoma, Angle Closure

A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber.


Unintended Pregnancy
Pregnancy, Unplanned
Unplanned Pregnancy

Unintended or accidental pregnancy, including pregnancy resulting from failed contraceptive measures.


A genus of chiefly Eurasian and African land snails including the principal edible snails as well as several pests of cultivated plants.


HLA-DC Antigens
HLA-DQ
HLA-MB
HLA-DS
HLA-DQ Antigens
HLA-DS Antigens
HLA-LB
HLA-DC
HLA-MB Antigens
HLA-LB Antigens

A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.


Angiography, Coronary
Coronary Angiography

Radiography of the vascular system of the heart muscle after injection of a contrast medium.


Cytological Technique
Cytologic Technics
Techniques, Cytological
Technics, Cytological
Cytological Techniques
Technic, Cytological
Cytological Technic
Technique, Cytological
Cytological Technics


Social Accountability
Accountability
Obligation, Social
Communitarianism
Social Responsibility
Responsibility, Social
Obligations to Society
Future Generations

A movement in social thought that emphasizes the responsibilities of the individual within the larger community.


Sex Determination Technics
Sex Determination Analysis
Sex Determination Techniques

Validation of the SEX of an individual by inspection of the GONADS and/or by genetic tests.


Diabetes Mellitus, Non Insulin Dependent

A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.


An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)


Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease

Insulin-Like-Growth Factor Binding Protein-4 Protease

Pregnancy Associated alpha Plasma Protein

A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.


CDC33 Gene Product
Eukaryotic Peptide Initiation Factor-4E
Eukaryotic Initiation Factor-4E
EIF4E
EIF-4E
Peptide Initiation Factor EIF-4E

A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.


MAPK1 Mitogen-Activated Protein Kinase
p42(Mapk) Kinase
p42 MAP Kinase
Mitogen-Activated Protein Kinase 1
MAP Kinase 2
MAPK2 Mitogen-Activated Protein Kinase
p42 MAPK
Extracellular Signal-Regulated Kinase 2
p42(Mitogen-Activated Protein Kinase)
Mitogen-Activated Protein Kinase 2
p42(Mapk)

A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.


COX2 Inhibitors
Cyclooxygenase 2 Inhibitors
Cyclooxygenase-2 Inhibitors
Coxibs
COX-2 Inhibitors

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.


Out-of-Frame Insertion
Frameshift Mutation
Out-of-Frame Deletion
Frame Shift Mutation
Out-of-Frame Mutation
Mutation, Frameshift

A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.


Infections, Torovirus
Torovirus Infections

Infections with viruses of the genus TOROVIRUS, family CORONAVIRIDAE.


Glutaryl CoA Dehydrogenase
Glutaryl-Coenzyme A Dehydrogenase
Glutaryl-CoA Dehydrogenase

A flavoprotein enzyme that is responsible for the catabolism of LYSINE; HYDROXYLYSINE; and TRYPTOPHAN. It catalyzes the oxidation of GLUTARYL-CoA to crotonoyl-CoA using FAD as a cofactor. Glutaric aciduria type I is an inborn error of metabolism due to the deficiency of glutaryl-CoA dehydrogenase.


Societies, Pharmacy
Society, Pharmaceutical
Pharmacy Societies
Societies, Pharmaceutical
Societies, Pharmaceutic
Pharmaceutical Society
Pharmaceutic Society
Pharmaceutical Societies
Pharmacy Society
Pharmaceutic Societies
Society, Pharmaceutic
Society, Pharmacy

Societies whose membership is limited to pharmacists.


Hemolytic Anemia, Congenital Nonspherocytic

Anemia, Congenital Nonspherocytic Hemolytic

Anemia, Hemolytic Congenital, Nonspherocytic

Anemia, Hemolytic, Congenital Nonspherocytic

Congenital Nonspherocytic Hemolytic Anemia

Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. Common causes include deficiencies in GLUCOSE-6-PHOSPHATE ISOMERASE; PYRUVATE KINASE; and GLUCOSE-6-PHOSPHATE DEHYDROGENASE.


Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.


Guanosine 5'-triphosphate 2'(3')-diphosphate. A guanine nucleotide containing five phosphate groups. Three phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis. Synonym: magic spot II.


TAL Effectors
Transcription Activator-Like Effectors

Virulence factors of pathogenic plant bacteria, such as XANTHOMONAS species, that bind to specific sequences in the PROMOTER REGIONS of host DNA to induce transcription of specific host genes.  Variations in the DNA binding domain of TALE family members account for the variations in DNA specificity. The TALE DNA-binding domains are used in various GENETIC TECHNIQUES by fusing them with various DNA modifying enzymes to detect and manipulate sequence-specific targeted DNA sites.


Law of Nations
International Law
Public International Law

The body of law that governs the legal relations between or among sovereign states or nations.


A phylum of fungi that produce their sexual spores (basidiospores) on the outside of the basidium. It includes forms commonly known as mushrooms, boletes, puffballs, earthstars, stinkhorns, bird's-nest fungi, jelly fungi, bracket or shelf fungi, and rust and smut fungi.


Corticotrophin
Corticotropin
ACTH (1-39)
Adrenocorticotropic Hormone
Corticotropin (1-39)
Adrenocorticotropin
ACTH
Adrenocorticotrophic Hormone
1-39 ACTH
Corticotrophin (1-39)

An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).


A complete or partial separation of the EPIPHYSES from the DIAPHYSES.


Lentinula edodes
Lentinus edodes
Shiitake Mushrooms

Mushrooms in the order AGARICALES containing B vitamins, cortinelin, and the polysaccharide LENTINAN.


Cordran Flurandrenolone Haelan Flurandrenolide

A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)


Adaptor Protein Complex 4
Adaptor-Related Protein Complex 4
AP-4 protein complex

An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.


Photopic Vision
Daylight Vision
Color Vision

Function of the human eye that is used in bright illumination or in daylight (at photopic intensities). Photopic vision is performed by the three types of RETINAL CONE PHOTORECEPTORS with varied peak absorption wavelengths in the color spectrum (from violet to red, 400 - 700 nm).


Hyperinsulinism, Familial, with Pancreatic Nesidioblastosis

An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.


p38alpha Mitogen-Activated Protein Kinase

Cytokine Suppressive Anti-inflammatory Drug Binding Protein

A 38-kDa mitogen-activated protein kinase that is abundantly expressed in a broad variety of cell types. It is involved in the regulation of cellular stress responses as well as the control of proliferation and survival of many cell types. The kinase activity of the enzyme is inhibited by the pyridinyl-imidazole compound SB 203580.


A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*11 and DRB1*12 alleles.


Interleukin-2 Receptors alpha
Interleukin-2Ralpha
CD25 Antigens
Antigens, CD25
Interleukin-2 Receptor alpha
Interleukin-2 Receptor alpha Subunit
Tac P55 Peptide
CD25 Antigen
Interleukin-2 Receptor alpha Chain
IL-2Ralpha
alpha-subunit, Receptor, Interleukin-2

A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-2.


Vesicoureteral Reflux
Vesico-Ureteral Reflux
Vesicoureteral Reflux 1

Retrograde flow of urine from the URINARY BLADDER into the URETER. This is often due to incompetence of the vesicoureteral valve leading to ascending bacterial infection into the KIDNEY.


Natural Cytotoxicity Triggering Receptor 1

A 46-kD stimulatory receptor found on resting and activated NATURAL KILLER CELLS. It has specificity for VIRAL HEMAGGLUTININS that are expressed on infected cells.


Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.


Lipoatrophic Diabetes
Diabetes Mellitus, Lipoatrophic

A type of diabetes mellitus that is characterized by severe INSULIN RESISTANCE and LIPODYSTROPHY. The latter may be generalized, partial, acquired, or congenital (LIPODYSTROPHY, CONGENITAL GENERALIZED).


A genus of RHODOCYCLACEAE occurring as rod-shaped cells embedded in a gelatinous matrix. It includes Z. filipendula.


Peripheral Blood Stem Cell Transplantation

Transplantation of PERIPHERAL BLOOD STEM CELLS. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.


Infectious Disease Transmission, Patient-to-Professional

The transmission of infectious disease or pathogens from patients to health professionals or health care workers. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.


Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.


Comamonas acidovorans
Delftia acidovorans
Pseudomonas acidovorans

A species of gram-negative rod-shaped bacteria found ubiquitously and formerly called Comamonas acidovorans and Pseudomonas acidovorans. It is the type species of the genus DELFTIA.


Aphasmidia Infections
Adenophorea Infections
Infections, Adenophorea
Infections, Aphasmidia

Infections with nematodes of the subclass ADENOPHOREA.


Hydrocarbons, Iodinated
Iodinated Hydrocarbons

Hydrocarbon compounds with one or more HYDROGEN atoms substituted with IODINE.


Deoxyribonucleases, Type I, Site Specific

Deoxyribonucleases, Type I, Site-Specific

Deoxyribonucleases, Type I Site-Specific

Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.


Receptors, Stretch, Arterial
Stretch Receptors, Arterial
Pressoreceptors
Stretch Receptors, Vascular
Baroreceptors
Receptors, Stretch, Vascular

Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.


Chelating Agents
Metal Antagonists
Chelators
Complexons
Metal Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.


Seborrheic Keratosis
Keratosis Seborrheica
Keratosis, Seborrheic

Benign eccrine poromas that present as multiple oval, brown-to-black plaques, located mostly on the chest and back. The age of onset is usually in the fourth or fifth decade.


Apocytochrome b
Cytochrome b
Cytochromes b

Cytochromes of the b group that have alpha-band absorption of 563-564 nm. They occur as subunits in MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III.


Service Costs, Direct
Direct Service Costs
Costs, Direct Service

Costs which are directly identifiable with a particular service.


Cell Surface Glycoproteins
Membrane Glycoprotein
Surface Glycoproteins
Membrane Glycoproteins
Cell Surface Glycoprotein
Surface Glycoprotein

Glycoproteins found on the membrane or surface of cells.


Ritter's Disease
Ritter Disease
Staphylococcal Scalded-Skin Syndrome
Staphylococcal Scalded Skin Syndrome
Scalded Skin Syndrome, Staphylococcal

A disease of infants due to group 2 phage type 17 staphylococci that produce an epidermolytic exotoxin. Superficial fine vesicles and bullae form and rupture easily, resulting in loss of large sheets of epidermis.


Klippel-Feil Syndrome
Vertebral Cervical Fusion Syndrome
Dystrophia Brevicollis Congenita
Klippel-Feil Sequence
Cervical Fusion Syndrome

A syndrome characterised by a low hairline and a shortened neck resulting from a reduced number of vertebrae or the fusion of multiple hemivertebrae into one osseous mass.


Hip Dislocation
Hip Dysplasia
Hip Displacement

Displacement of the femur bone from its normal position at the HIP JOINT.


Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems.


Cervical Intraepithelial Neoplasia, Grade III

A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)


Antimitotic Drugs
Antimitotic Agents
Antimitotics

Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.


A lipotropic peptide that is the N-terminal fragment of beta-lipotropin. It is a peptide of 56 amino acids in humans and 58 amino acids in pigs.


HLA Class I Histocompatibility Antigen, A-24 alpha Chain

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*24 allele family.


Allachesthesia Allochiria Dyschiria Alloesthesia Allesthesia

A condition in which a person is unable to tell which side of the body has been touched.


Idiopathic Myelofibrosis
Primary Myelofibrosis
Myelosclerosis
Agnogenic Myeloid Metaplasia
Myelosis, Nonleukemic
Chronic Idiopathic Myelofibrosis
Fibrosis, Bone Marrow
Bone Marrow Fibrosis
Myelofibrosis
Myeloid Metaplasia
Myelofibrosis With Myeloid Metaplasia

A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.


Microbial, plant, or animal cells which are immobilized by attachment to solid structures, usually a column matrix. A common use of immobilized cells is in biotechnology for the bioconversion of a substrate to a particular product. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)


Physical activity of the FETUS in utero. Gross or fine fetal body movement can be monitored by the mother, PALPATION, or ULTRASONOGRAPHY.


Facial Transplant
Face Transplant
Face Transplantation
Facial Transplantation

The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.


Idiopathic Interstitial Pneumonia
Idiopathic Interstitial Pneumonias

A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.


Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.


Adaptive Clinical Trials as Topic
Adaptive Clinical Trial as Topic
Adaptive Clinical Trial Design

Works about clinical studies in which a prospectively planned opportunity is included to modify trial designs and hypotheses based on analysis of data from subjects in the study.


Nursing, Home
Home Care, Nonprofessional
Home Care, Non-Professional
Home Nursing

Nursing care given to an individual in the home. The care may be provided by a family member or a friend. Home nursing as care by a non-professional is differentiated from HOME CARE SERVICES provided by professionals: visiting nurse, home health agencies, hospital, or other organized community group.


Nevus, Pigmented
Nevi, Pigmented
Nevus, Melanocytic
Nevi, Melanocytic
Pigmented Moles

A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.


Mercapto Compounds
Sulfhydryl Compounds
Mercaptans
Thiols


RNA-Induced Silencing Complex
RISC Multicomponent Nuclease

A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).


Defensive Practice
Medicine, Defensive
Defensive Medicine

The alterations of modes of medical practice, induced by the threat of liability, for the principal purposes of forestalling lawsuits by patients as well as providing good legal defense in the event that such lawsuits are instituted.


Tetramethylthiuram Disulfide
Thiuram
Nobecutan
Sadoplon 75
Thiram
TMT Disulfide
Bacteriostat
Thiuram D
TMTD

A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.


Anemia, Refractory, with Excess of Blasts

Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.


Hypoxia, Cellular
Anoxia, Cellular
Cell Anoxia
Cell Hypoxia

A condition of decreased oxygen content at the cellular level.


Research, Nursing Clinical
Clinical Research, Nursing
Research, Clinical Nursing
Nursing Clinical Research
Clinical Practice Nursing Research
Clinical Nursing Research
Nursing Research, Clinical

Research carried out by nurses in the clinical setting and designed to provide information that will help improve patient care. Other professional staff may also participate in the research.


Ubiquitin-Specific Peptidases
Ubiquitin-Specific Proteases
Ubiquitin-Specific Protease Family

Members of the peptidase C19 family which regulate signal transduction by removing UBIQUITIN from specific protein substrates via a process known as deubiquitination or deubiquitylation.


Plant Photoreceptors
Photoreceptors, Plant

Plant proteins that mediate LIGHT SIGNAL TRANSDUCTION. They are involved in PHOTOTROPISM and other light adaption responses during plant growth and development . They include the phototropins, phytochromes (PHYTOCHROME), and members of the ubiquitous cryptochrome family.


Cultural Body Modification
Non-Therapeutic Body Modification
Body Modification, Non-Therapeutic

The wounding of the body or body parts by branding, cutting, piercing (BODY PIERCING), or TATTOOING as a cultural practice or expression of creativity or identity.


A NAD-dependent oxidoreductase that catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5,10-methenyl-tetrahdyrofolate. It has been found in a variety of microorganisms.


Cutaneous Elimination
Cutaneous Excretion

The discharge of substances from the blood supply to the glands of the skin and excretion in the SWEAT and SEBUM.


Brain Ventricular Neoplasms
Cerebral Ventricle Tumors
Intraventricular Neoplasms
Neoplasms, Cerebral Ventricle
Cerebral Ventricle Neoplasms
Neoplasms, Intraventricular
Ventricular Tumors, Brain
Neoplasms, Cerebroventricular
Cerebroventricular Neoplasms
Ventricular Neoplasms, Brain
Neoplasms, Ventricular, Brain

Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.


Molecular Libraries, Small
Small Molecule Libraries
Chemical Libraries

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions. It includes virtual libraries.


Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.


Non-AB Component of AD Amyloid Protein
alpha-Synuclein

A synuclein that is a major component of LEWY BODIES and plays a role in SYNUCLEINOPATHIES, neurodegeneration and neuroprotection.


Chelating agent used for heavy metal poisoning and assay. It causes diabetes.


Dopamine and cAMP-Regulated Phosphoprotein 32

Dopamine and Adenosine 3',5'-Monophosphate-Regulated Phosphoprotein

Dopamine- and Cyclic AMP-Regulated Phosphoprotein Mr 32,000

A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.


Sharks of the family Squalidae, also called dogfish sharks. They comprise at least eight genera and 44 species. Their LIVER is valued for its oil and its flesh is often made into fertilizer.


Minichromosome Maintenance Complex Component 8

A minichromosome maintenance protein that forms a hexameric complex with MINICHROMSOME MAINTENANCE COMPLEX COMPONENT 9. The MCM8-MCM9 helicase complex is involved in HOMOLOGOUS RECOMBINATION REPAIR following the formation of DNA interstrand cross-links.


Laboratory Critical Values
Laboratory Alert Values

Test results which deviate substantially from normal ranges of REFERENCE VALUES or other qualitative results. They trigger CLINICAL LABORATORY SERVICES to place a special alert to ensure PATIENT SAFETY.


Estrogens, Nonsteroidal
Estrogens, Non-Steroidal

Non-steroidal compounds with estrogenic activity.


Aluminum Oxide (Al2O)
Aluminum Oxide (AlO2)
Bauxite
Corundum
Sapphire
Aluminum Oxide (Al130O40)
Alumina
Alumina Ceramic
Aluminum Oxide

An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.


Faculty, Nursing
Nursing Faculties
Faculties, Nursing
Nursing Faculty

The teaching staff and members of the administrative staff having academic rank in a nursing school.


Chromosome Inversion
Inversion, Chromosome
Inversion, Chromosomal

An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.


Buruli Ulcer Disease
Infections, Mycobacterium ulcerans
Buruli Ulcer
Mycobacterium ulcerans Infection

A lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa.


A group of XANTHENES that contain a 9-keto OXYGEN.


Hepatitis B Virus, Woodchuck
Woodchuck Hepatitis B Virus
Woodchuck Hepatitis Virus
Hepatitis Virus, Woodchuck

An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. It closely resembles the human hepatitis B virus.


PI-3 Kinase
PI-3K
Phosphatidylinositol 3-Kinases
PI3-Kinase
PtdIns 3-Kinase
PI3 Kinases
Phosphoinositide 3 Kinases
PI 3-Kinase
PtdIns 3-Kinases
Phosphatidylinositol-3-OH Kinase
Phosphoinositide 3-Hydroxykinase

Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.


Cervix Dentis
CEJ
Tooth Cervix
Cementoenamel Junction

The constricted part of the tooth at the junction of the crown and root or roots. It is often referred to as the cementoenamel junction (CEJ), the line at which the cementum covering the root of a tooth and the enamel of the tooth meet. (Jablonski, Dictionary of Dentistry, 1992, p530, p433)


Spousal Abuse
Spouse Abuse
Wife Abuse
Partner Abuse

Deliberate severe and repeated injury to one domestic partner by the other.


The specialty or practice of nursing in the care of the orthopedic patient.


alpha-Endosulfan Endosulfan beta-Endosulfan Thiodon Thiotox Thiodan

A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61)


Receptors, Oncostatin M, Type II
Oncostatin M Type II Receptor

A subtype of oncostatin receptors that are formed by dimerization of ONCOSTATIN M RECEPTOR BETA SUBUNIT and CYTOKINE RECEPTOR GP130. They are activated specifically by ONCOSTATIN M and signal through interaction of their cytoplasmic domains with JANUS KINASES.


Sialitis
Salivary Gland Inflammation
Sialadenitis
Chronic Sialadenitis
Sialoadenitis
Adenitis, Salivary Gland
Irradiation-Induced Sialadenitis

INFLAMMATION of salivary tissue (SALIVARY GLANDS), usually due to INFECTION or injuries.


Silybum marianum
Milk Thistle
Carduus marianus

The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L.


Pain in the adjacent areas of the teeth.


Adapalene, Benzoyl Peroxide Drug Combination

Adapalene - Benzoyl Peroxide Drug Combination

Adapalene-Benzoyl Peroxide Drug Combination

Adapalene Benzoyl Peroxide Drug Combination

A pharmaceutical preparation of adapalene and benzoyl peroxide that is used as a DERMATOLOGIC AGENT for the topical treatment of ACNE.


Capillary Zone Electrophoresis
Electrophoresis, Capillary

A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)


Aspiration, Psychology
Aspirations, Psychology
Aspirations, Psychological
Aspiration, Psychological

Strong desires to accomplish something. This usually pertains to greater values or high ideals.


ATP-Dependent Citrate Lyase
ATP Citrate Lyase
Citrate Cleavage Enzyme
ATP Citrate (pro-3S)-Lyase
ATP Citrate (pro-S)-Lyase
ATP Citrate Synthase

An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.


Gram Positive Endospore Forming Bacteria

Bacteria that form endospores and are gram-positive. Representative genera include BACILLUS; CLOSTRIDIUM; MICROMONOSPORA; SACCHAROPOLYSPORA; and STREPTOMYCES.


Chronic Idiopathic Intestinal Pseudo-Obstruction

A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.


Left Ventricular Hypertrophy
Hypertrophy, Left Ventricular
Ventricular Hypertrophy, Left

Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.


CD44 Antigens
Hyaluronan-Binding Protein
Antigens, CD44
Chondroitin Sulfate Proteoglycan 8
Receptors, Hyaluronan
Hyaluronan Receptor
Hyaluronan Receptors
CD44 Antigen
Hyaluronic Acid Binding Protein

Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary THYMOCYTES; GRANULOCYTES; MACROPHAGES; erythrocytes, and fibroblasts. Their interaction with HYALURONIC ACID mediates binding of lymphocytes to high endothelial VENULES.


NAD(P)H Dehydrogenase (FMN)
FMN Reductase
NAD(P)H-Flavin Oxidoreductase
NADPH-Flavin Reductase
NADH-FMN Oxidoreductase
NADH-Flavin Oxidoreductase
NAD(P)H-FMN Oxidoreductase
Flavin Mononucleotide Reductase
FMN Oxidoreductase

An enzyme that utilizes NADH or NADPH to reduce FLAVINS. It is involved in a number of biological processes that require reduced flavin for their functions such as bacterial bioluminescence. Formerly listed as EC 1.6.8.1 and EC 1.5.1.29.


Postmenopausal Osteoporosis
Bone Loss, Perimenopausal
Osteoporosis, Post-Menopausal
Osteoporosis, Postmenopausal
Bone Loss, Postmenopausal
Perimenopausal Bone Loss
Postmenopausal Bone Loss

Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.


A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.


Learning, Instrumental
Operant Conditioning
Instrumental Learning
Conditioning, Operant

Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.


Auditory Ganglion
Spiral Ganglia
Spiral Ganglion
Ganglion of Corti

The sensory ganglion of the COCHLEAR NERVE. The cells of the spiral ganglion send fibers peripherally to the cochlear hair cells and centrally to the COCHLEAR NUCLEI of the BRAIN STEM.


Practicing, Psychology
Practicing, Psychological
Practice, Psychology
Practice, Psychological
Practice (Psychology)

Performance of an act one or more times, with a view to its fixation or improvement; any performance of an act or behavior that leads to learning.


N-Acetylglucosamine Receptor
GlcNAc Specific Lectin
N-Acetylglucosamine Specific Lectin
N-Acetylglucosamine Receptors
Receptor, N-Acetylglucosamine
Receptors, N-Acetylglucosamine

Cell surface receptors that bind to ACETYLGLUCOSAMINE.


Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma

A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.


A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)


TRAF2
LMP1-Associated Protein 1
TNF Receptor-Associated Factor 2

A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 1 to inhibit APOPTOSIS.


Commercial Oils
Oils, Industrial
Industrial Oils
Polishes

Oils which are used in industrial or commercial applications.


Glial Activating Factor
Fibroblast Growth Factor 9

A fibroblast growth factor that was originally identified as a mitogen for GLIAL CELLS. It is expressed primarily in NEURONS.


Creosote Bush
Larrea tridentata
Larrea
Gobernadora

A plant genus of the family ZYGOPHYLLACEAE. It is sometimes called chaparral but that is a generic word which is used with a number of other plants. Members contain NORDIHYDROGUAIARETIC ACID.


An NADPH oxidase that contains four EF HANDS and is expressed primarily by SPERMATOCYTES and LYMPHOCYTES, as well as by endothelial cells. It functions as a calcium-dependent proton channel to generate SUPEROXIDES that regulate cell growth, APOPTOSIS; and PHYSIOLOGIC ANGIOGENESIS.


Channelopathy-Associated Insensitivity To Pain

A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)


A division of multicellular organisms that was a subkingdom under Animalia in the old five kingdom paradigm.


One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).


Smith-Magenis Syndrome
Chromosome 17p11.2 Deletion Syndrome
17p11.2 Monosomy

Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.


o-Aminoazotoluene
ortho-Aminoazotoluene
C.I. Solvent Yellow 3

An azo dye with carcinogenic properties.


United States. Dept. of Homeland Security

United States Department of Homeland Security

A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to domestic national security.


Anemia, Addison's
Addison's Anemia
Pernicious Anemia
Anemia, Pernicious

A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)


Monocyte Chemotactic Activating Factor 3

A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. Chemokine CCL7 has specificity for CCR1 RECEPTORS; CCR2 RECEPTORS; and CCR5 RECEPTORS.


Inflammation of the parametrium, the connective tissue of the pelvic floor, extending from the subserous coat of the uterus laterally between the layers of the BROAD LIGAMENT.


Murine coronavirus
Hepatitis Virus, Mouse
Gastroenteritis Virus, Murine
Murine hepatitis virus
Mouse Hepatitis Virus
Murine Gastroenteritis Virus
MHV-JHM


Burns produced by contact with electric current or from a sudden discharge of electricity.


Complexes of RNA-binding proteins with ribonucleic acids (RNA).


A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.


Subthalamic Nucleus
Body of Luys
Nucleus of Luys
Nucleus Subthalamicus
Subthalamic Nucleus of Luys
Corpus Luysi

Lens-shaped structure on the inner aspect of the INTERNAL CAPSULE. The SUBTHALAMIC NUCLEUS and pathways traversing this region are concerned with the integration of somatic motor function.


Volvulus
Intestinal Volvulus
Volvulus, Intestine

A twisting in the intestine (INTESTINES) that can cause INTESTINAL OBSTRUCTION.


Diffuse Large-Cell Lymphoma
Lymphoma, Large Lymphoid, Diffuse
Lymphoma, Large Cell, Diffuse
Large Lymphoid Lymphoma, Diffuse
Histiocytic Lymphoma
Large-Cell Lymphoma, Diffuse
Lymphoma, Histiocytic
Lymphoma, Histiocytic, Diffuse
Lymphoma, Large-Cell, Diffuse
Histiocytic Lymphoma, Diffuse
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Diffuse Large-Cell
Diffuse, Large B-Cell, Lymphoma

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.


Insurance, Medigap
Medigap Insurance
Medicare Supplement Insurance
Medicare Supplemental Insurance
Medigap Policy

A supplemental health insurance policy sold by private insurance companies and designed to pay for health care costs and services that are not paid for either by Medicare alone or by a combination of Medicare and existing private health insurance benefits. (From Facts on File Dictionary of Health Care Management, 1988)


Chenopodium ambrosioides
Wormseed
Epazote

A plant species of the genus Chenopodium known for toxicity to intestinal worms and other simple organisms.


Q-Type Voltage-Dependent Calcium Channels

CALCIUM CHANNELS located in the neurons of the brain.


Eck Fistula
Portacaval Shunt, Surgical
Surgical Portacaval Shunt
Portacaval Shunt
Portacaval Anastomosis
Shunt, Surgical Portacaval

Surgical portasystemic shunt between the portal vein and inferior vena cava.


Strongylocentrotus purpuratus
Purple Sea Urchin

A species of SEA URCHINS in the family Strongylocentrotidae found on the Pacific coastline from Alaska to Mexico. This species serves as a major research model for molecular developmental biology and other fields.


HMG-I(Y) Protein
High Mobility Group I(Y) Protein
HMG I-Type Protein
HMG I-Y Phosphoprotein
HMGA1a Protein
HMGI Protein
HMGI(Y) Gene Product
AT-Hook 1a Protein, High Mobility Group

An 11-kDa AT-hook motif-containing (AT-HOOK MOTIFS) protein that binds to the minor grove of AT-rich regions of DNA. It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation.


Benzodiazepines
Benzodiazepine
Benzodiazepine Compounds

A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.


The type species of YATAPOXVIRUS, a tumor-producing DNA virus discovered in monkeys in Yaba, Nigeria. It has been found to produce histiocytomas in monkeys and humans.


Cyclodol
Trihexyphenidyl
Benzhexol
Hipokinon
Artane
Parkinane
Apo-Trihex
Trihexidyl Hydrochloride
Trihexyphenidyl Hydrochloride
Trihexane
Parkopan
Trihexyphenidyl Hydrochloride Elixir

One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.


Genes, Immediate-Early
Immediate-Early Genes

Genes that show rapid and transient expression in the absence of de novo protein synthesis. The term was originally used exclusively for viral genes where immediate-early referred to transcription immediately following virus integration into the host cell. It is also used to describe cellular genes which are expressed immediately after resting cells are stimulated by extracellular signals such as growth factors and neurotransmitters.


Arterivirus Infections
Infections, Arterivirus

Infections caused by viruses of the genus ARTERIVIRUS.


Ribosome Subunits, Small, Bacterial
Small Ribosome Subunits, Bacterial
30S Ribosome Subunits, Bacterial
Small Ribosomal Subunits, Bacterial
Ribosomal Subunits, 30S, Bacterial
Ribosomal Subunits, Small, Bacterial
Bacterial Small Ribosomal Subunits
30S Ribosomal Subunits, Bacterial
Bacterial Small Ribosome Subunits
Ribosome Subunits, 30S, Bacterial

The small subunit of eubacterial RIBOSOMES. It is composed of the 16S RIBOSOMAL RNA and about 23 different RIBOSOMAL PROTEINS.


A fluorene derivative that is used in combination with ARTEMETHER for the treatment of MALARIA (see ARTEMETHER-LUMEFANTRINE DRUG COMBINATION).


Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.


An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.


A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.


A metabolic excess of REACTIVE NITROGEN SPECIES, including NITRIC OXIDE and PEROXYNITRITE, that leads to damaging effects of oxidation and nitration.


The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.


Porichthys Toadfishes Batrachoidiformes Opsanus

Genus in the family Batrachoididae whose members possess an elongated, tapered body.


Prekallikrein Activator
Factor 12A
Factor XIIa
Factor Twelve A
Hageman-Factor Fragments
Factor XII, Activated
Activated Factor XII
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa

Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.


Obesity-Hypoventilation Syndrome
Pickwickian Syndrome
Obesity Hypoventilation Syndrome

HYPOVENTILATION syndrome in very obese persons with excessive ADIPOSE TISSUE around the ABDOMEN and DIAPHRAGM. It is characterized by diminished to absent ventilatory chemoresponsiveness; chronic HYPOXIA; HYPERCAPNIA; POLYCYTHEMIA; and long periods of sleep during day and night (HYPERSOMNOLENCE). It is a condition often related to OBSTRUCTIVE SLEEP APNEA but can occur separately.


Hypoplastic Anemia, Congenital
Anemia, Hypoplastic, Congenital
Congenital Hypoplastic Anemia

An inborn condition characterized by deficiencies of red cell precursors that sometimes also includes LEUKOPENIA and THROMBOCYTOPENIA.


Central Spinal Cord Syndrome
Central Cord Syndrome
Central Cord Injury Syndrome

A syndrome associated with traumatic injury to the cervical or upper thoracic regions of the spinal cord characterized by weakness in the arms with relative sparing of the legs and variable sensory loss. This condition is associated with ischemia, hemorrhage, or necrosis involving the central portions of the spinal cord. Corticospinal fibers destined for the legs are spared due to their more external location in the spinal cord. This clinical pattern may emerge during recovery from spinal shock. Deficits may be transient or permanent.


A technique encompassing morphometry, densitometry, neural networks, and expert systems that has numerous clinical and research applications and is particularly useful in anatomic pathology for the study of malignant lesions. The most common current application of image cytometry is for DNA analysis, followed by quantitation of immunohistochemical staining.


A pattern recognition receptor that recognizes GUANOSINE and URIDINE-rich single-stranded RNA.


A disease of pregnant and lactating cows and ewes leading to generalized paresis and death. The disease, which is characterized by hypocalcemia, occurs at or shortly after parturition in cows and within weeks before or after parturition in ewes.


A family of marine mollusks in the class BIVALVIA, commonly known as oysters. They have a rough irregular shell closed by a single adductor muscle.


Ether, Ethyl
Diethyl Ether
Ether
Ethyl Ether

A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.