Cytotrophoblasts Syncytiotrophoblasts Trophoblast Trophoblasts

Trophoblasts with multinuclear cytoplasm and undefined cellular structures. Syncytiotrophoblasts secrete proteolytic enzymes that erode the ENDOMETRIUM for EMBRYO IMPLANTATION. They also produce steroid, peptide, and protein hormones (PLACENTAL HORMONES).


Ligamentum Teres Femoris
Round Ligament of Femur
Ligamentum Capitis Femoris

Ligament that connects the fovea of the FEMUR HEAD and the ACETABULUM notch in the HIP JOINT.


ATP Binding Cassette Transporter, Sub-Family B

ATP Binding Cassette Transporter, Subfamily B

ATP-Binding Cassette, Sub-Family B Proteins

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.


An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.


Proto-Oncogene Protein Int-1 Related Protein

A proto-oncogene protein and member of the Wnt family of proteins. It is frequently up-regulated in human GASTRIC CANCER and is a tumor marker (BIOMARKERS, TUMOR) of gastric and COLORECTAL CANCER.


Mass Administration
Mass Drug Administration

Administration of a medication to at-risk individuals in a population without individual diagnosis. It is often used in order to treat, control, and/or prevent spread of often endemic DISEASE OUTBREAKS such as NEGLECTED DISEASES in high disease burden areas.


Buckwheat, Wild
Buckwheat, Red
Eriogonum

A plant genus of the family POLYGONACEAE.


A hapten capable of eliciting both antibody formation and delayed hypersensitivity when bound to aromatic amino acids, polypeptides or proteins. It is used as an immunologic research tool.


Enamel Agenesis
Enamel Hypoplasia, Dental
Hypoplasia, Dental Enamel
Dental Enamel Hypoplasia
Enamel Hypoplasia
Molar Incisor Hypomineralization
Hypoplastic Enamel

A type of developmental disturbance of AMELOGENESIS involving permanent INCISORS and first permanent MOLARS. It is characterized by asymmetrical enamel defects with severe hypomineralization.


Peptidoglycan TGase
Peptidoglycan Transglycosylase
Peptidoglycan Glycosyltransferase

A hexosyltransferase involved in the transfer of disaccharide molecules to the peptidoglycan structure of the CELL WALL SKELETON. It plays an important role in the genesis of the bacterial CELL WALL.


Low Tension Glaucoma
Normal Tension Glaucoma

A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure.


High Mobility Group-Box Domains
HMG-Box Domains
HMG-1-Box Domain
HMG-Box Domain

DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)


Docosahexaenoic Acid Dimer (All-Z Isomer)

Docosahexaenoic Acid, 4,7,10,13,16,19-(All-Z-Isomer), Cesium Salt

Docosahexaenoic Acid, 4,7,10,13,16,19-(All-Z-Isomer), Potassium Salt

Docosahexaenoic Acid, 4,7,10,13,16,19-Isomer, Sodium Salt

Docosahexaenoic Acid, 4,7,10,13,16,19-(All-Z-Isomer), Cerium Salt

C22-unsaturated fatty acids found predominantly in FISH OILS.


RNA Polymerase III
RNA Polymerase C
DNA-Dependent RNA Polymerase III

A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure where it transcribes DNA into RNA. It has specific requirements for cations and salt and has shown an intermediate sensitivity to alpha-amanitin in comparison to RNA polymerase I and II.


An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.


Glutamate Oxaloacetate-Transaminase-1
Aspartate Aminotransferase, Cytoplasmic

An aspartate aminotransferase found in the CYTOPLASM.


Cervical Dilatation
Labor, First Stage
Labor Stage, First

Period from the onset of true OBSTETRIC LABOR to the complete dilatation of the CERVIX UTERI.


A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy.


A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.


Colitis, Microscopic
Microscopic Colitis

A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology.


TAPA-1 Antigen
CD81 Antigen
Antigens, CD81
Tetraspanin 28

A tetraspanin protein that is involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.


Membrane-Bound Immunoglobulins
Surface Immunoglobulins
Membrane Bound Immunoglobulin
Receptors, Antigen, B-Cell
Immunoglobulins, Membrane-Bound
Receptors, Antigen, B Cell
B-Cell Antigen Receptors
Antigen Receptors, B-Cell
Immunoglobulins, Surface

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.


Respiratory Circulation
Circulation, Pulmonary
Pulmonary Circulation
Circulation, Respiratory

The circulation of the BLOOD through the LUNGS.


Potassium Channel, Tandem Pore Domain
Potassium Channels, Baseline
Potassium Channels, Leak
Potassium Channels, Background
Tandem Pore Domain Potassium Channel
K+ Channels, Tandem Pore Domain
Potassium Channel, Leak
Potassium Channels, Tandem Pore Domain
Potassium Channel, Background
Tandem Pore Domain Potassium Channels
Potassium Channel, Baseline

Potassium channels that contain two pores in tandem. They are responsible for baseline or leak currents and may be the most numerous of all K channels.


Polyethylene Terephthalates
PET Polymer
Dacron
Polyethylene Terephthalate
Nalophan
Poly(Ethylene Terephtalate)
Tedlar

Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.


Growth Inhibitors
Cell Growth Inhibitors

Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).


NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase

An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).


Clopindol Clopidol 3,5-Dichloro-2,6-dimethyl-4-pyridinol Meticlorpindol

A very effective anticoccidial agent used in poultry.


Members of spacecraft crew including those who travel in space, and those in training for space flight.


A growth differentiation factor that is closely-related in structure to BONE MORPHOGENETIC PROTEIN 3. Growth differentiation factor 10 is found at high levels in BONE, however it plays an additional roles in regulating EMBRYONIC DEVELOPMENT.


Neurocysticercosis
Cysticercosis, Central Nervous System
Central Nervous System Cysticercosis
Cysticercosis, Brain

Infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus TAENIA (primarily T. solium in humans). Lesions formed by the organism are referred to as cysticerci. The infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. SEIZURES represent the most common clinical manifestation although focal neurologic deficits may occur. (From Joynt, Clinical Neurology, 1998, Ch27, pp46-50)


An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.


Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.


Adenocarcinoma, Scirrhous
Carcinoma, Scirrhous

An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)


Obesity, Maternal
Maternal Obesity
Obesity in Pregnancy

BODY MASS INDEX in PREGNANT WOMEN that is excessively above the recommended cut-off.


Congenital absence of or defects in structures of the jaw.


Endoplasmic Reticulum, Smooth
Endoplasmic Reticulum, Agranular

A type of endoplasmic reticulum lacking associated ribosomes on the membrane surface. It exhibits a wide range of specialized metabolic functions including supplying enzymes for steroid synthesis, detoxification, and glycogen breakdown. In muscle cells, smooth endoplasmic reticulum is called SARCOPLASMIC RETICULUM.


Polygonum cuspidatum
Japanese Knotweed
Knotweed, Japanese
Fallopia japonica

A plant species of the family POLYGONACEAE. Itadori tea is prepared from the root of this genus.


17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.


VLA Receptors
Very Late Activation Antigen Receptors
VLA Protein Complex
Receptor, Very Late Antigen
Receptors, Very Late Antigen
Very Late Antigen Receptors
VLA Differentiation Antigens
Receptors, Very Late Activation Antigen
Receptors, VLA
VLA Activation Antigens

Members of the integrin family appearing late after T-cell activation. They are a family of proteins initially identified at the surface of stimulated T-cells, but now identified on a variety of cell types. At least six VLA antigens have been identified as heterodimeric adhesion receptors consisting of a single common beta-subunit and different alpha-subunits.


CD14 Antigen
Antigens, CD14
CD14 Monocyte Differentiation Antigen
Receptor, LPS
Receptors, Lipopolysaccharide
Lipoglycan Receptor
Receptor, Lipoglycan
Lipopolysaccharide Receptors
LPS Receptor
CD14 Antigens

Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including MONOCYTES; MACROPHAGES; and some GRANULOCYTES. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.


Caroli's Disease
Caroli's Syndrome
Caroli Disease

Congenital cystic dilatation of the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). It consists of 2 types: simple Caroli disease is characterized by bile duct dilatation (ectasia) alone; and complex Caroli disease is characterized by bile duct dilatation with extensive hepatic fibrosis and portal hypertension (HYPERTENSION, PORTAL). Benign renal tubular ectasia is associated with both types of Caroli disease.


Homing Receptors, T-Cell
Homing Receptor, Lymph Node
Hermes Antigen Family
Receptors, Lymphocyte Homing
Receptor, Lymph Node Homing
Lymphocyte Homing Receptors
Lymph Node Homing Receptor

Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialized blood vessels called high endothelial venules. Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. The adhesion plays a crucial role in the trafficking of lymphocytes.


Antigen-Presenting Cells
Accessory Cells, Immunologic
Immunologic Accessory Cells
Cells, Immunologic Accessory
Immunologic Accessory Cell
Cell, Immunologic Accessory
Accessory Cell, Immunologic

A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.


Fibroodontoma
Odontoma
Fibro-odontoma, Ameloblastic
Odontoma, Compound
Fibro-Odontoma

A mixed tumor of odontogenic origin, in which both the epithelial and mesenchymal cells exhibit complete differentiation, resulting in the formation of tooth structures. (Jablonski, Illustrated Dictionary of Dentistry, 1982)


A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.


A biomineral consisting of layers of crystalized ARAGONITE, separated by interlamellar layers of organic matrix containing beta-CHITIN, and surrounded by an intercrystalline organic membrane of silk fibroin. Nacre is the iridescent substance better known as mother-of-pearl that is secreted by MOLLUSCS.


Electrical Conductivity
Electric Conductivity

The ability of a substrate to allow the passage of ELECTRONS.


Enamel Proteins, Dental
Proteins, Dental Enamel
Dental Enamel Proteins

The proteins that are part of the dental enamel matrix.


Type A Personality
Personality Type A
Coronary-Prone Personality

Established behavior pattern characterized by excessive drive and ambition, impatience, competitiveness, sense of time urgency, and poorly contained aggression.


Nautical Medicine
Naval Medicine
Medicine, Naval
Medicine, Nautical

The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.


A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.


Onlay, Dental
Dental Onlay
Inlays
Dental Inlay
Dental Onlays
Inlays, Dental
Onlays
Dental Inlays
Inlay, Dental
Onlays, Dental

Restorations of metal, porcelain, or plastic made to fit a cavity preparation, then cemented into the tooth. Onlays are restorations which fit into cavity preparations and overlay the occlusal surface of a tooth or teeth. Onlays are retained by frictional or mechanical factors.


Deleted in Colorectal Carcinoma Protein
DCC Tumor Suppressor Protein
DCC Receptor
DCC-Netrin-1 Receptor

A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1.  Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.


DNA isolated from fossils or other ancient specimens.


Nosocomial Pneumonia
Healthcare-Associated Pneumonia
Hospital Acquired Pneumonia

Infection of the lung often accompanied by inflammation that is acquired through an interaction within a healthcare institution often through a therapeutic experience (e.g., use of catheters or ventilators).


Medical Care Research
Research, Health Services
Healthcare Research
Action Research
Health Services Research
Research, Medical Care
Health Services Evaluation
Health Care Research

The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)


Test, Immunologic Pregnancy
Immunological Pregnancy Tests
Pregnancy Test, Immunologic
Immunologic Pregnancy Tests
Pregnancy Tests, Immunologic
Tests, Immunological Pregnancy
Tests, Immunologic Pregnancy
Immunologic Pregnancy Test
Pregnancy Tests, Immunological

Methods of detecting pregnancy by examining the levels of human chorionic gonadotropin (HCG) in plasma or urine.


Dihydrotestosterone
5-alpha Dihydrotestosterone
Androstanolone
5-alpha-DHT
5 beta-Dihydrotestosterone
Andractim
17 beta-Hydroxy-5 beta-Androstan-3-One
Dihydroepitestosterone
Stanolone
Gelovit
Anaprotin
17beta-Hydroxy-5alpha-Androstan-3-One
5 alpha-Dihydrotestosterone

A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.


National Human Genome Research Institute (U.S.)

National Center for Human Genome Research (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research into the mapping of the human genome and other organism genomes. The National Center for Human Genome Research was established in 1989 and re-named the National Human Genome Research Institute in 1997.


Dentist-Patient Relations
Dentist-Patient Relationship

The psychological relations between the dentist and patient.


INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM.


ERBF
Blood Flow, Renal, Effective
Effective Renal Blood Flow
Renal Blood Flow, Effective

The amount of the RENAL BLOOD FLOW that is going to the functional renal tissue, i.e., parts of the KIDNEY that are involved in production of URINE.


Wounds, Nonpenetrating
Injuries, Blunt
Nonpenetrating Injuries
Injuries, Nonpenetrating
Blunt Injuries

Injuries caused by impact with a blunt object where there is no penetration of the skin.


Vaccines, Live, Attenuated
Vaccines, Attenuated

Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.


Voltage-Gated Sodium Channel beta-4 Subunit

A voltage-gated sodium channel beta subunit subtype that covalently associates with voltage-gated alpha subunits. Defects in the SCN4B gene, which codes for this beta subunit, are associated with long QT syndrome-10.


Choices and ways of doing things that predominate or are fashionable among ordinary people in a society during a point in time.


Melanoma-Specific Antigens
Melanoma Antigens

Cellular antigens that are specific for MELANOMA cells.


N,N',N'',N'''-Tetraisopropylpyrophosphamide. A specific inhibitor of pseudocholinesterases. It is commonly used experimentally to determine whether pseudo- or acetylcholinesterases are involved in an enzymatic process.


Muscle Tonus
Muscle Tightness
Muscular Tension
Muscle Tension

The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)


An emergency treatment commonly used to clear food and other foreign objects causing AIRWAY OBSTRUCTION.


Ranid Herpesvirus 1
Leopard Frog Carcinoma Virus
Lucke frog herpesvirus
Herpesvirus 1, Ranid
Lucke Tumor Virus

A species of the family HERPESVIRIDAE, whose genus is so far unassigned. It is probably the causative agent of ADENOMA or ADENOCARCINOMA in the kidneys of certain frogs.


Calcium Pyrophosphate
Calcium Pyrophosphate (2:1)
Calcium Pyrophosphate Dihydrate
Calcium Pyrophosphate, Monohydrate
Calcium Pyrophosphate (1:2)
Calcium Diphosphate
Calcium Pyrophosphate (1:1)

An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).


Bacteriological Technique
Bacteriologic Technic
Techniques, Bacteriological
Technique, Bacteriological
Bacteriological Techniques
Technics, Bacteriological
Bacteriologic Techniques
Bacteriologic Technics
Technic, Bacteriological


Phospholipid-Sensitive Calcium-Dependent Protein Kinase

Calcium Phospholipid-Dependent Protein Kinase

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.


Nox Proteins
NAD(P)H Oxidases
NADPH Oxidases
NAD(P)H oxidase
NADPH Oxidase

A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.


Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.


Threonine Deaminase
Threonine Dehydratase
Threonine Ammonia-Lyase
Threonine Dehydrase

A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.


Placental-Site Trophoblastic Tumor
Trophoblastic Tumor, Placental Site
Trophoblastic Tumor, Placental

An uncommon variant of CHORIOCARCINOMA. It is composed almost entirely of mononuclear cytotrophoblasts (TROPHOBLASTS). Because its secretion of hCG (CHORIONIC GONADOTROPIN) is low, a large tumor may develop before the hCG can be detected.


Cell Division Control Protein 42 Homolog

G25K GTP-Binding Protein, Placental Isoform

A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS. It is associated with a diverse array of cellular functions including cytoskeletal changes, filopodia formation and transport through the GOLGI APPARATUS. This enzyme was formerly listed as EC 3.6.1.47.


Trypanosoma brucei brucei
Trypanosoma brucei

A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).


Receptors, Purinergic P2Y
P2Y Purinoceptor
P2Y Purinoceptors

A subclass of purinergic P2 receptors whose signaling is coupled through a G-PROTEIN signaling mechanism.


Macro-Creatine Kinase
ATP Creatine Phosphotransferase
ADP Phosphocreatine Phosphotransferase
Creatine Phosphokinase
Creatine Kinase

A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.


Pathological processes involving the PENIS or its component tissues.


Services offered to the library user. They include reference and circulation.


Schizophrenia, Childhood
Childhood-Onset Schizophrenia
Childhood Schizophrenia

An obsolete concept, historically used for childhood mental disorders thought to be a form of schizophrenia. It was in earlier versions of DSM but is now included within the broad concept of PERVASIVE DEVELOPMENT DISORDERS.


Reticulum Cell-Like Sarcoma, Yoshida
Sarcoma, Yoshida


SLC5A2 Protein
SGLT2 Protein
Sodium-Glucose Transporter 2

A sodium-glucose transporter that is expressed in the luminal membrane of the PROXIMAL KIDNEY TUBULES.


Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.


Sutureless Repair
Sutureless Surgery
Sutureless Surgical Procedures
Sutureless Repair Technique

Surgical techniques in which SUTURES are not applied to surgical wounds.


Type VI Secretion System
T6SS Secretion Systems
Bacterial Secretion System, Type VI
Type VI Secretion Systems
Type 6 Secretion Systems
Type 6 Secretion System

Multiprotein complexes in GRAM NEGATIVE BACTERIA that deliver effector proteins into eukaryotic or prokaryotic cells by a mechanism similar to the contractile tail of bacteriophages. They are composed of a cell envelope-spanning tube which is surrounded by a contractile sheath and tipped by a cell puncturing complex; a base plate structure that anchors the assembly to the cell envelope; and an ATPase involved in the sheath contraction and disassembly of the complex.


Type I Interleukin-4 Receptor
Receptors, Interleukin-4, Type I
Interleukin-4 Receptors, Type I
IL-4 Receptors, Type I
Type I Interleukin-4 Receptors
Interleukin-4 Receptor Type I

An interleukin-4 receptor subtype that is found predominantly on hematopoietic cells. It is a heterodimer of the INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.


Retinal Dehydrogenase
Cytosolic Retinal Dehydrogenase
Retinaldehyde Dehydrogenase

A metalloflavoprotein enzyme involved the metabolism of VITAMIN A, this enzyme catalyzes the oxidation of RETINAL to RETINOIC ACID, using both NAD+ and FAD coenzymes. It also acts on both the 11-trans- and 13-cis-forms of RETINAL.


Chest, Medicine
Chests, Medicine
Medicine Chest
Medicine Chests

Boxes in which physicians kept their drugs and other medications, medical instruments and supplies, manuals, etc. As a carrying case or convenient storage receptacle, or a kind of portable pharmacy, the medicine chest was indispensable to the itinerant physician. The chest was usually larger and sturdier than a doctor's kit or bag.


Brain Stem Infarctions
Top of the Basilar Syndrome
Infarctions, Brain Stem
Infarctions, Brainstem
Benedict Syndrome
Brainstem Infarctions
Millard-Gublar Syndrome
Weber Syndrome
Brainstem Stroke
Brain Stem Infarct
Claude Syndrome
Foville Syndrome

Infarctions that occur in the BRAIN STEM which is comprised of the MIDBRAIN; PONS; and MEDULLA OBLONGATA. There are several named syndromes characterized by their distinctive clinical manifestations and specific sites of ischemic injury.


Automated External Defibrillators
Defibrillators, External
Stimulators, Electrical, Cardiac, Shock
Defibrillators
Electric Shock Cardiac Stimulators

Cardiac electrical stimulators that apply brief high-voltage electroshocks to the HEART. These stimulators are used to restore normal rhythm and contractile function in hearts of patients who are experiencing VENTRICULAR FIBRILLATION or ventricular tachycardia (TACHYCARDIA, VENTRICULAR) that is not accompanied by a palpable PULSE. Some defibrillators may also be used to correct certain noncritical dysrhythmias (called synchronized defibrillation or CARDIOVERSION), using relatively low-level discharges synchronized to the patient's ECG waveform. (UMDNS, 2003)


Maintenance of Luteal Function
Corpus Luteum Maintenance
Luteal Maintenance

Process of maintaining the functions of CORPORA LUTEA, specifically PROGESTERONE production which is regulated primarily by pituitary LUTEINIZING HORMONE in cycling females, and by PLACENTAL HORMONES in pregnant females. The ability to maintain luteal functions is important in PREGNANCY MAINTENANCE.


Phospholipases A2, Cytosolic
Cytosolic Phospholipases A2
cPLA2 Phospholipases

A subcategory of phospholipases A2 that occur in the CYTOSOL.


Idiopathic CD4 Positive T-Lymphocytopenia

Reproducible depletion of CD4+ lymphocytes below 300 per cubic millimeter in the absence of HIV infection or other known causes of immunodeficiency. This is a rare, heterogeneous syndrome and does not appear to be caused by a transmissible agent.


CYP17 Family
Cytochrome P450 Family 17
CYP17 Enzymes

A cytochrome P450 enzyme family that functions in the biosynthesis of STEROIDS and includes STEROID 17-ALPHA-HYDROXYLASE.


D-3-Hydroxybutyrate Dehydrogenase
Hydroxybutyrate Dehydrogenase
D-beta-Hydroxybutyrate Dehydrogenase
3-Hydroxybutyrate Dehydrogenase


Dihydroxypropyltheophylline Dyphylline Dilin Diphylline Diprophylline Lufyllin Dylix Neothylline

A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis.


Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN.


L-Serine O-Acetyltransferase
Serine Acetyltransferase
Serine Transacetylase
Serine O-Acetyltransferase

An enzyme that catalyzes the conversion of L-SERINE to COENZYME A and O-acetyl-L-serine, using ACETYL-COA as a donor.


A congenital abnormality that is characterized by a blocked CHOANAE, the opening between the nose and the NASOPHARYNX. Blockage can be unilateral or bilateral; bony or membranous.


PTS2 Protein
Peroxisomal Targeting Signal 2 Receptor
Pex7p
PTS2 Receptors
Peroxin-7
PEX7 Protein
PTS2 Receptor

A cytoplasmic receptor and peroxin that contains a series of WD40 REPEATS and binds to PEROXISOME TARGETING SIGNAL 2. It is essential for protein import into PEROXISOMES; mutations in the human PEX7 gene are associated with PEROXISOMAL DISORDERS such as Type 1 CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC.


Nematospiroides dubius
Heligmosomoides polygyrus

A species of intestinal nematode parasites which occur most commonly in mice. Infection is by ingesting larvae. This particular species is used extensively in immunological research.


Ear Diseases
Otological Diseases
Otologic Diseases

Pathological processes of the ear, the hearing, and the equilibrium system of the body.


Fibronectin Type III Domains
Fibronectin Type III Domain
FN III Domain
FN Type III Domain

A highly conserved immunoglobulin-like protein domain of about 100 amino acids that forms a beta sandwich structure.


Technics and Procedures, Diagnostic
Techniques and Procedures, Diagnostic
Diagnostic Technics and Procedures
Diagnostic Techniques and Procedures

Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.


A pattern recognition receptor that is expressed in LUNG and in B-LYMPHOCYTES.


Otological Diagnostic Technics
Diagnostic Techniques, Otologic
Diagnostic Technics, Otologic
Diagnostic Techniques, Otological
Otological Diagnostic Techniques
Techniques, Otological Diagnostic
Otological Diagnostic Technique
Diagnostic Technique, Otological
Technique, Otological Diagnostic
Otological Diagnostic Technic
Diagnostic Technic, Otological
Technics, Otological Diagnostic
Technic, Otological Diagnostic
Diagnostic Technics, Otological

Methods and procedures for the diagnosis of diseases of the ear or of hearing disorders or demonstration of hearing acuity or loss.


Equine Encephalomyelitis Virus Infections

Infections, Equine Encephalomyelitis Virus

Equine Encephalomyelitis Viral Infections

A group of ALPHAVIRUS INFECTIONS which affect horses and man, transmitted via the bites of mosquitoes. Disorders in this category are endemic to regions of South America and North America. In humans, clinical manifestations vary with the type of infection, and range from a mild influenza-like syndrome to a fulminant encephalitis. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-10)


A class of amoeboid EUKARYOTES that forms either filiform subpseudopodia or lobopodia. Characteristics include the absence of sorocarps, sporangia, or similar fruiting bodies. Lobosea were formerly members of the phylum Sarcomastigophora, subphylum Sarcodina, under the old five kingdom paradigm.


A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.


A natural product that has been considered as a growth factor for some insects.


Eye Injuries, Penetrating
Penetrating Eye Injuries
Injuries, Penetrating Eye

Deeply perforating or puncturing type intraocular injuries.


Radioimmunosorbent Assay of Allergens
Radioallergosorbent Test

An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.


Government-controlled hospitals which represent the major health facility for a designated geographic area.


Fatty Acid Synthase, Bacterial, Plant, and Fungi Form

The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.


A nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.


A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly overexpressed in primary BRAIN TUMORS and in experimental models of GLIOMA.


A sterol usually substituted with radioactive iodine. It is an adrenal cortex scanning agent with demonstrated high adrenal concentration and superior adrenal imaging.


e-Nose
Electronic Tongue
Artificial Nose
Electronic Nose

A device used to detect airborne odors, gases, flavors, volatile substances or vapors.


Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.


A group of desmosomal cadherins with cytoplasmic tails that resemble those of classical CADHERINS.


Platelet Glycoprotein Ia
CD49b Antigens
VLA-2 alpha Chain
Antigens, CD49b
GPIa
Integrin alpha2
alpha2 Integrin
CD49b Antigen

An integrin alpha subunit that primarily combines with INTEGRIN BETA1 to form the INTEGRIN ALPHA2BETA1 heterodimer. It contains a domain which has homology to collagen-binding domains found in von Willebrand factor.


Bowhead Whale
Greenland, Right Whale
Right Whale, Greenland
Balaena mysticetus

The species Balaena mysticetus, in the family Balaenidae, found in the colder waters of the Northern Hemisphere. The common name is derived from the extreme arching of the lower jaw.


Pyruvate Decarboxylase (Lipoamide)
Pyruvate Dehydrogenase (Lipoamide)
Pyruvate Dehydrogenase-E1
Pyruvate Dehydrogenase Component E1

The E1 component of the multienzyme PYRUVATE DEHYDROGENASE COMPLEX. It is composed of 2 alpha subunits (pyruvate dehydrogenase E1 alpha subunit) and 2 beta subunits (pyruvate dehydrogenase E1 beta subunit).


tertiary-Butyl Alcohol
t-Butanol
tert-Butyl Alcohol
tert-Butanol

An isomer of butanol that contains a tertiary butyl group that consists of three methyl groups, each separately attached to a central (tertiary) carbon.


The study of the structures of organisms for applications in art: drawing, painting, sculpture, illustration, etc.


Endothelium-Dependent Vasodilators
Endothelium-Dependent Relaxing Factor
Endothelium-Derived Relaxant Factor
Neutrophil-Derived Relaxant Factor
Endothelium-Derived Relaxing Factor
Endothelium-Dependent Relaxing Factors

Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been identified, including NITRIC OXIDE and PROSTACYCLIN.


The aggregate business enterprise of manufacturing textiles. (From Random House Unabridged Dictionary, 2d ed)


Amazon Manatee
Trichechus inunguis
Manatee, Brazilian
Manatee, Amazon
Brazilian Manatee

Member of the genus Trichechus found in the Amazon and Orinoco drainages of northeastern South America. (From Scott, Concise Encyclopedia Biology, 1996)


TFIIIB-beta
Transcription Factor TFIIIB
TFIIIB-alpha
TFIIIB
Transcription Factor IIIB

One of several general transcription factors that are specific for RNA POLYMERASE III. TFIIIB recruits and positions pol III over the initiation site and remains stably bound to the DNA through multiple rounds of re-initiation by RNA POLYMERASE III.


Peripheral Nerve Injury
Peripheral Nerve Injuries


Influenza A Virus, H7N1 Subtype
H7N1 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 7 and neuraminidase 1. This subtype has demonstrated the ability to mutate from a low pathogenic form to a highly pathogenic form in birds. It was responsible for a 1999 outbreak in turkeys in Italy.


Bcl10 Protein
B-Cell CLL-Lymphoma 10 Protein
Bcl-10 Protein
B-Cell Lymphoma-Leukemia 10 Protein

A signal transducing adaptor protein that contains an N-terminal CARD DOMAIN and functions in the ADAPTIVE IMMUNE RESPONSE. It promotes PRO-CASPASE-9 maturation and APOPTOSIS, activation of NF-KAPPA B, and is a substrate for MALT1 PARACASPASE.


Common member of the Gramineae family used as cattle FODDER. It harbors several fungi and other parasites toxic to livestock and people and produces allergenic compounds, especially in its pollen. The most commonly seen varieties are L. perenne, L. multiflorum, and L. rigidum.


Complement Component 2b
Complement 2b
Complement C2b
Complement C2b Fragment
C2b Complement

The N-terminal fragment of COMPLEMENT 2, released by the action of activated COMPLEMENT C1S.


Influenza A Virus, H7N9 Subtype
H7N9 Virus

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 7 and neuraminidase 9. This avian origin virus was first identified in humans in 2013.


A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.


Carboxylase Deficiency, Multiple, Neonatal Form

Infantile Multiple Carboxylase Deficiency

Early-Onset Combined Carboxylase Deficiency

Early-Onset Biotin-Responsive Multiple Carboxylase Deficiency

Multiple Carboxylase Deficiency, Neonatal Form

Deficiency, Multiple Carboxylase, Neonatal Form

Multiple Carboxylase Deficiency, Early Onset

The neonatal form of MULTIPLE CARBOXYLASE DEFICIENCY that is caused by a defect or deficiency in holocarboxylase synthetase. HLCS is the enzyme that covalently links biotin to the biotin dependent carboxylases (propionyl-CoA-carboxylase, pyruvate carboxylase, and beta-methylcrotonyl-CoA carboxylase).


Psychoanalytic Theory
Oral Character
Theory, Psychoanalytic
Psychoanalytical Theory

Conceptual system developed by Freud and his followers in which unconscious motivations are considered to shape normal and abnormal personality development and behavior.


Migration-Inhibition Factors, Leukocyte
Leukocyte Migration-Inhibitory Factors
Leukocyte Migration-Inhibition Factors
Migration-Inhibitory Factors, Leukocyte

Protein factor(s) released by sensitized lymphocytes (and possibly other cells) that inhibit the movement of LEUKOCYTES, especially polymorphonuclear cells, away from their site of release. Assays for these factors are used as tests for cellular immunity. Two of the common assays are the LEUKOCYTE MIGRATION CAPILLARY TUBE TECHNIQUE (LMCT) and the LEUKOCYTE MIGRATION AGAROSE TEST (LMAT).


Flavivirus Infections
Infections, Flavivirus

Infections with viruses of the genus FLAVIVIRUS, family FLAVIVIRIDAE.


A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).


Methane-Oxidizing Bacteria
Methylococcaceae
Methane Oxidizing Bacteria
Methylomonadaceae
Methylmonadaceae
Methanomonadaceae

A family of gram-negative, aerobic bacteria utilizing only one-carbon organic compounds and isolated from in soil and water.


GLPR Proteins
Glucagon-Like Receptors
Glucagon-Like Peptide Receptors

G-PROTEIN COUPLED CELL SURFACE RECEPTORS that bind GLUCAGON-LIKE PEPTIDES and are expressed by cells in pancreatic, intestinal, and neural tissues. These receptors regulate cellular responses to BLOOD GLUCOSE, INSULIN, and INFLAMMATION signals.


Antifolates
Dihydrofolate Reductase Inhibitors
Folic Acid Metabolism Inhibitors
Folic Acid Antagonists

Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)


A highly selective and specific beta antagonist that is used to characterize beta-adrenoceptors.


Mannose-Binding Lectins
Mannose-Specific Lectin

A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE.


Aggressive Systemic Mastocytosis
Indolent Systemic Mastocytosis
Systemic Mast-Cell Disease
Mastocytosis, Systemic

A form of systemic mastocytosis in which patients experience no pain. It is characterized by the multifocal mast cell filtrates, mostly in skin and bone marrow (<20% MAST CELLS). It has a low cytomorphological grade.


An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.


Apoptotic Protease-Activating Factor 1
Apaf-1 Protease-Activating Factor
Apoptotic Peptidase Activating Factor 1

A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.


Dental Fistulas
Gingival Fistula
Fistula, Dental
Fistulas, Dental
Dental Fistula

An abnormal passage in the oral cavity on the gingiva.


Cuff Tear Arthropathy
Milwaukee Shoulder Syndrome
Rotator Cuff Tear Arthropathy
Milwaukee Shoulder

Rapidly destructive shoulder joint and bone disease found mainly in elderly, and predominantly in women. It is characterized by SHOULDER PAIN; JOINT INSTABILITY; and the presence of crystalline CALCIUM PHOSPHATES in the SYNOVIAL FLUID. It is associated with ROTATOR CUFF INJURIES.


Polydipsia, Primary
Polydipsia, Psychogenic

A clinical disorder characterized by excessive fluid intake (polydipsia); HYPONATREMIA; and POLYURIA in SCHIZOPHRENIA and other psychiatric disorders. Impaired water metabolism in psychogenic polydipsia can result in WATER INTOXICATION.


Psychological Conflict
Conflict, Psychological
Conflict, Psychology

The internal individual struggle resulting from incompatible or opposing needs, drives, or external and internal demands. In group interactions, competitive or opposing action of incompatibles: antagonistic state or action (as of divergent ideas, interests, or persons). (from Merriam-Webster's Collegiate Dictionary, 10th ed)


jun-NH2-Terminal Kinase
c-jun N-Terminal Kinase
c-jun Amino-Terminal Kinase
jun-NH2-Terminal Kinases
JNK Mitogen-Activated Protein Kinases

A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.


Enterotoxigenic E. coli
E coli, Enterotoxigenic
Enterotoxigenic Escherichia coli
ETEC
Escherichia coli, Enterotoxigenic

Strains of ESCHERICHIA COLI that produce or contain at least one member of either heat-labile or heat-stable ENTEROTOXINS. The organisms colonize the mucosal surface of the small intestine and elaborate their enterotoxins causing DIARRHEA. They are mainly associated with tropical and developing countries and affect susceptible travelers to those places.


Inflammatory Response Syndrome, Systemic

A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.


Twelfth Cranial Nerve
Nerve XII
Hypoglossal Nerve
Cranial Nerve XII
Nervus Hypoglossus

The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.


A type II keratin that is found associated with the KERATIN-12 in the CORNEA and is regarded as a marker for corneal-type epithelial differentiation. Mutations in the gene for keratin-3 have been associated with MEESMANN CORNEAL EPITHELIAL DYSTROPHY.


Long-Term Care Insurance
Insurance, Long-Term Care

Health insurance to provide full or partial coverage for long-term home care services or for long-term nursing care provided in a residential facility such as a nursing home.


p24 protein, Human Immunodeficiency Virus

A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.


LacZ Genes
Lac Operon
Lac Gene
Lactose Operon

The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.


Signaling Lymphocytic Activation Molecule Family Member 2

Signaling Lymphocytic Activation Molecule 2

A 40-45 KDa GPI-linked protein in the SLAM family that consists of two IMMUNOGLOBULIN C2-SET DOMAINS. It is expressed on the surface of a variety of cells with immune functions, including THYMOCYTES; mature B-LYMPHOCYTES and T-LYMPHOCYTES; NATURAL KILLER CELLS; DENDRITIC CELLS; MAST CELLS; and EOSINOPHILS. It  binds to CD2 and 2B4 (CD244) receptors to activate and modulate the immunologic response.


RFID
Radio Frequency Identification Device
Radio Frequency Identification

Machine readable patient or equipment identification device using radio frequency from 125 kHz to 5.8 Ghz.


Vesicular Acetylcholine Transporter Proteins

Vesicular Acetylcholine Transport Proteins

Vesicular amine transporter proteins that transport the neurotransmitter ACETYLCHOLINE into small SECRETORY VESICLES. Proteins of this family contain 12 transmembrane domains and exchange vesicular PROTONS for cytoplasmic acetylcholine.


Tiorphan
Thiorphan, (S)-Isomer
(3-Mercapto-2-benzylpropionyl)glycine
Thiorphan, (R)-Isomer
Thiorphan

A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.


Behavior pattern characterized by a generally calm and even-tempered demeanor. Emotionally, such personality types show less frequent irritation, anger, hostility, and aggression than Type A individuals. (from International Encyclopedia of the Social Sciences, 2008, p. 223)


Insulin, Lysyl(28B)-Prolyl(28B)-
LYSPRO
28(B)-Lysine-29(B)-Prolineinsulin
Insulin, Lys(28B)-Pro(29B)-
Lispro
28(B)-Lys-29(B)-Pro-Insulin
Humalog
Insulin Lispro
Humalog Kwikpen

Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.


A macrolide antibiotic isolated from cultures of Streptomyces lucensis.


Myofunctional Therapy
Oral Myotherapy
Orofacial Myology
Orofacial Myotherapy

Training or retraining of the buccal, facial, labial, and lingual musculature in toothless conditions; DEGLUTITION DISORDERS; TEMPOROMANDIBULAR JOINT DISORDERS; MALOCCLUSION; and ARTICULATION DISORDERS.


Oocyte Collection
Oocyte Retrieval
Oocyte Aspiration

Procedures to obtain viable OOCYTES from the host. Oocytes most often are collected by needle aspiration from OVARIAN FOLLICLES before OVULATION.


The individuals employed by the hospital.


Futility, Medical
Treatment Futility
Medical Futility
Futile Treatment
Futility

The absence of a useful purpose or useful result in a diagnostic procedure or therapeutic intervention. The situation of a patient whose condition will not be improved by treatment or instances in which treatment preserves permanent unconsciousness or cannot end dependence on intensive medical care. (From Ann Intern Med 1990 Jun 15;112(12):949)


Monitors, Blood Pressure
Sphygmomanometers, Continuous
Blood Pressure Monitors

Devices for continuously measuring and displaying the arterial blood pressure.


Leukemia, Myeloid, Acute, M3
AML M3
Leukemia, Promyelocytic, Acute
M3 ANLL
Leukemia, Acute Promyelocytic
Progranulocytic Leukemia
Acute Promyelocytic Leukemia
Promyelocytic Leukemia, Acute
Myeloid Leukemia, Acute, M3
Leukemia, Progranulocytic

An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.


Acholeplasma laidlawii
Mycoplasma laidlawii

An organism originally isolated from sewage, manure, humus, and soil, but recently found as a parasite in mammals and birds.


COMP (Cartilage Oligomeric Matrix Protein)

Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.


Kölliker-Fuse Nucleus
Kolliker-Fuse Nucleus

A nucleus in the pons associated with RESPIRATION RATE control.


Receptor, Melanocortin 3
MC3 Receptor
Melanocortin Receptor 3
Receptor, Melanocortin, Type 3
Melanocortin-3 Receptor

A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH; GAMMA-MSH and ADRENOCORTICOTROPIC HORMONE.


AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.


A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.


Achilles Tendon
Calcaneal Tendon
Tendo Calcaneus

Tendon that connects the muscles in the back of the calf to the HEEL BONE.


Pidolic Acid
Pyrrolidonecarboxylic Acid
5-Ketoproline
Pyroglutamic Acid
Magnesium Pidolate
5-Oxopyrrolidine-2-Carboxylic Acid
Pyroglutamate
5-Oxoproline

A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.


A tooth that is prevented from erupting by a physical barrier, usually other teeth. Impaction may also result from orientation of the tooth in an other than vertical position in the periodontal structures.


Electron Cryomicroscopy
Cryo-electron Microscopy
Cryoelectron Microscopy

Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.


Aberrant chromosomes with no ends, i.e., circular.


Gastrin-Releasing Peptide
Gastrin-Releasing Peptide (1-27)

Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.


Single Photon Emission Computed Tomography Computed Tomography

An imaging technique using a device which combines TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON and TOMOGRAPHY, X-RAY COMPUTED in the same session.


The family Erinaceidae, in the order INSECTIVORA. Most are true hedgehogs possessing a coat of spines and a very short tail. Those members of the family found in Southeast Asia (moonrats or gymnures) have normal body hair and a long tail.


Abutments, Dental
Abutment, Dental
Dental Abutments
Dental Abutment

Natural teeth or teeth roots used as anchorage for a fixed or removable denture or other prosthesis (such as an implant) serving the same purpose.


A facility set up for the purpose of handling large volumes of telephone calls. Call Centers typically utilize some form of computer automation for receiving, dispatching, screening, logging and forwarding telephone calls.


Neuronal Differentiation Factor, Cholinergic

A family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor (RECEPTORS, ERBB-2). Multiple variant forms of NEUREGULINS occur due to alternative splicing of their mRNAs. The NEUREGULINS include products from the three known genes (NGR1; NGR2 and NGR3).


Surgical Diathermy
Thermocoagulation
Electrocoagulation
Diathermy, Surgical
Endocavitary Fulguration
Electrocautery
Galvanocautery

Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.


Neuroreceptors
Nerve Endings, Sensory
Receptors, Neural
Sensory Receptor Cells
Neurons, Sensory
Receptors, Sensory
Neural Receptors
Sensory Receptors
Sensory Neurons

Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.


Troleandomycin Oleandocetin Triacetyloleandomycin TAO

A macrolide antibiotic that is similar to ERYTHROMYCIN.


Complement Cytolysis Inhibiting Agents
Complement Inhibiting Agents
Complement Inhibitors
Complement Inactivating Agents

Compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host.


Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.


Fibronectins
Opsonic Glycoprotein
Fibronectin
alpha 2-Surface Binding Glycoprotein
Opsonic alpha(2)SB Glycoprotein
LETS Proteins
Cold-Insoluble Globulins

Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.


RNase D
Ribonuclease III
Ribonuclease D
RNase III
Dicer Enzyme

An endoribonuclease that is specific for double-stranded RNA. It plays a role in POST-TRANSCRIPTIONAL RNA PROCESSING of pre-RIBOSOMAL RNA and a variety of other RNA structures that contain double-stranded regions.


The study and treatment of defects in binocular vision resulting from defects in the optic musculature or of faulty visual habits. It involves a technique of eye exercises designed to correct the visual axes of eyes not properly coordinated for binocular vision.


Carbon Sequestration
Carbon Sequestration Techniques
Carbon Sink

Any of several processes for the permanent or long-term artificial or natural capture or removal and storage of carbon dioxide and other forms of carbon, through biological, chemical or physical processes, in a manner that prevents it from being released into the atmosphere.


Guanylate Cyclase
Inosinate Cyclase
Guanyl Cyclase
Guanylyl Cyclase
Deoxyguanylate Cyclase

An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.


Dynamin 3
T-Dynamin
Dynamin, Testicular
Dynamin III

A subtype of dynamin found expressed exclusively in the testis, lung and brain.


Dental Fluorosis
Dental Fluoroses
Mottled Enamel
Fluoroses, Dental
Fluorosis, Dental

A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)


2-Isopropylmalate Synthase
alpha-Isopropylmalate Synthase

An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.


Air Pollutants, Radioactive
Radioactive Air Pollutants

Pollutants present in air which exhibit radioactivity.


POU Transcription Factor Oct-6
Octamer-Binding Protein Oct-6
Octamer Transcription Factor-6
Oct-6 Transcription Factor
SCIP Protein
Transcription Factor Tst-1
Transcription Factor Oct-6

An octamer transcription factor that plays an important role in the MYELIN SHEATH development by SCHWANN CELLS.


An acute form of MEGACOLON, severe pathological dilatation of the COLON. It is associated with clinical conditions such as ULCERATIVE COLITIS; CROHN DISEASE; AMEBIC DYSENTERY; or CLOSTRIDIUM ENTEROCOLITIS.


Tuberculosis, Multi-Drug Resistant
Tuberculosis, Drug-Resistant
Tuberculosis, MDR
Tuberculosis, Multidrug-Resistant

Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.


Education, Continuing Medical
Education, Medical, Continuing
Continuing Medical Education
Medical Education, Continuing

Educational programs designed to inform physicians of recent advances in their field.


IL-6beta-NF
CCAAT-Enhancer-Binding Protein-delta
C-EBP delta Protein
Nuclear Factor Interleukin 6beta
Interleukin-6beta Nuclear Factor

A member of the C-EBP protein family of transcription factors. It plays a key role in G0 PHASE mammary EPITHELIAL CELL growth arrest, and it is involved in transcriptional regulation of INTERLEUKIN 1; INTERLEUKIN 6; and TUMOR NECROSIS FACTOR-ALPHA.


Atlantoaxial Joint
Atlanto Axial Joint
Atlanto-Axial Joint

The joint involving the CERVICAL ATLAS and axis bones.


A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the LARYNX. This results in a floppy laryngeal wall making patency difficult to maintain.


Glial Cell-Line Derived Neurotrophic Factor

Glial Cell Line-Derived Neurotrophic Factor

The founding member of the glial cell line-derived neurotrophic factor family. It was originally characterized as a NERVE GROWTH FACTOR promoting the survival of MIDBRAIN dopaminergic NEURONS, and it has been studied as a potential treatment for PARKINSON DISEASE.


Materials, frequently computer applications, that combine some or all of text, sound, graphics, animation, and video into integrated packages. (Thesaurus of ERIC Descriptors, 1994)


HTLV-III gp160
gp160(HIV)
gp160 Envelope Glycoprotein, HIV
HIV Envelope Protein gp160
HIV Envelope Glycoprotein gp160
env Protein gp160, HIV
Envelope Glycoprotein gp160, HIV

An envelope protein of the human immunodeficiency virus that is encoded by the HIV env gene. It has a molecular weight of 160,000 kDa and contains numerous glycosylation sites. It serves as a precursor for both the HIV ENVELOPE PROTEIN GP120 and the HIV ENVELOPE PROTEIN GP41.


Programmed Cell Death, Type I
Classical Apoptosis
Classic Apoptosis
Caspase-Dependent Apoptosis
Programmed Cell Death
Apoptosis, Extrinsic Pathway
Apoptosis, Intrinsic Pathway
Apoptosis

Physiological forms of regulated cell death that occur during growth and development and tissue turnover.


Antitumor Assays, Xenograft Model
Xenograft Antitumor Assays
Tumor Xenograft Assay
Xenograft Model Antitumor Assays

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.


Arcuate Nucleus
Infundibular Nucleus
Arcuate Nucleus of Hypothalamus

A nucleus located in the middle hypothalamus in the most ventral part of the THIRD VENTRICLE near the entrance of the infundibular recess. Its small cells are in close contact with the EPENDYMA.


Merkel's Receptor
Receptor, Merkel
Merkel Receptors
Receptors, Merkel's
Merkel Cells

Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. Do not confuse with Merkel's corpuscle which is a combination of a neuron and an epidermal cell.


A species of gram-negative bacteria in the genus ALIIVIBRIO, which exhibits LUMINESCENCE. A. fischeri is found in a symbiotic relationship with the SQUID Euprymna scolopes.


Myoblasts
Muscle Cells, Precursor
Muscle Cells, Embryonic

Embryonic (precursor) cells of the myogenic lineage that develop from the MESODERM. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes (MYOCYTES, SKELETAL; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE).


Heparin Secretory Transforming Protein-1

Kaposi's Sarcoma Fibroblast Growth Factor

A HEPARIN binding fibroblast growth factor that may play a role in LIMB BUDS development.


Plantibodies
Antibodies, Plant-Derived
Plant Antibodies, Recombinant

Recombinant antibodies produced in TRANSGENIC PLANTS. The plants serve as BIOREACTORS to produce the antibodies for medical use or industrial processes.


T-Cell Leukemia Virus I Antibodies, Human

Human T Cell Leukemia Virus I Antibodies

Leukemia-Lymphoma Virus I Antibodies, Human T-Cell

Leukemia Lymphoma Virus I Antibodies, Human T Cell

T Cell Leukemia Virus I Antibodies, Human

T Cell Leukemia Virus I Antibodies, Adult

Human T-Cell Leukemia Virus I Antibodies

T-Cell Leukemia Virus I Antibodies, Adult

Antibodies reactive with the HTLV-I ANTIGENS.


Pharyngotympanic Tube
Auditory Tube
Eustachian Tube

A narrow passageway that connects the upper part of the throat to the TYMPANIC CAVITY.


Plasmablastic Diffuse Large B-cell Lymphoma

Plasmablasts Diffuse Large B-cell Lymphoma

Malignant lymphoma composed of large B lymphoid cells which have the immunophenotype of plasma cells and a predilection for the ORAL CAVITY.


Congenital Oculofacial Paralysis, Moebius

Congenital Ophthalmoplegia and Facial Paresis

Moebius Congenital Oculofacial Paralysis

A syndrome of congenital facial paralysis, frequently associated with abducens palsy and other congenital abnormalities including lingual palsy, clubfeet, brachial disorders, cognitive deficits, and pectoral muscle defects. Pathologic findings are variable and include brain stem nuclear aplasia, facial nerve aplasia, and facial muscle aplasia, consistent with a multifactorial etiology. (Adams et al., Principles of Neurology, 6th ed, p1020)


A species of fish in the cod family GADIDAE, known as the Atlantic cod. It is one of the most important commercial FISHES.


A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.


National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research for a national program in diabetes, endocrinology, and metabolic diseases; digestive diseases and nutrition; and kidney, urologic, and hematologic diseases. It was established in 1948.


Gamma-Glutamylphosphate Reductase
Beta-Glutamylphosphate Reductase
Glutamate-5-Semialdehyde Dehydrogenase
Glutamate-Semialdehyde Dehydrogenase
Glutamate 5-Semialdehyde Dehydrogenase

An NADP+ dependent enzyme that catalyzes the oxidation of L-glutamate 5-semialdehyde to L-glutamyl 5-phosphate. It plays a role in the urea cycle and metabolism of amino groups.


An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.


eEF-2-Specific Ca and Calmodulin-Dependent Protein Kinase III

Calcium-Calmodulin-Dependent Protein Kinase Type 3

A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.


Vacuolar ATPase
Vacuolar Proton-Translocating ATPases
Vacuolar H+-ATPase
Lysosomal Proton-Translocating ATPases
Vacuolar Membrane H(+)-ATPase
V-Type ATPase
Lysosomal F(1)F(0) ATPase
Vacuolar F(1)F(0) ATPases
Vacuolar F(1)F(0) ATPase

Proton-translocating ATPases that are involved in acidification of a variety of intracellular compartments.


EAAT-5 Excitatory Amino Acid Transporter

A glutamate plasma membrane transporter protein that is primarily expressed in the RETINA.


rab3 Proteins
rab3 Protein
rab3 GTP-Binding Proteins

A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in calcium-dependent EXOCYTOSIS. This enzyme was formerly listed as EC 3.6.1.47.


Abnormal balloon- or sac-like dilatation in the wall of any one of the iliac arteries including the common, the internal, or the external ILIAC ARTERY.


Retrospective Study
Retrospective Studies

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.


An enzyme found primarily in the LIVER that catalyzes the N-methylation of NICOTINAMIDE and other structurally related compounds.


Mannitol Mustard
Decranol
Degranol
Mannomustine
Mannitol Nitrogen Mustard
Mannitlost

Nitrogen mustard derivative alkylating agent used as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant.


Cold Autoinflammatory Syndrome 1 Protein

NACHT, LRR and PYD Domains-Containing Protein 3

NLR Family, Pyrin Domain-Containing 3 Protein

An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.


Drug Effects on Physiology
Drug Physiological Effects
Physiological Effects of Drugs

Activities which affect organs and systemic functions without regard to a particular disease.


Cardiac Murmurs
Innocent Murmurs
Heart Murmurs
Diastolic Murmurs

Heart sounds caused by vibrations resulting from the flow of blood through the heart. Heart murmurs can be examined by HEART AUSCULTATION, and analyzed by their intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc).


Meleagrid Herpesvirus 1
Herpesvirus 1, Meleagrid
Marek's Disease Virus Serotype 3
Turkey Herpesvirus

A species in the genus MAREK'S DISEASE-LIKE VIRUSES, in the family HERPESVIRIDAE, infecting turkeys.


Lamin A
Type A Lamins
Lamin Type A
Lamin A-C

A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.


A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.


Semen Quality
Semen Analysis
Semen Quality Analysis

Measurable parameters of semen related to male fertility (e.g., SPERM COUNT; SPERM MOTILITY, volume, concentration, morphology, and viability).


An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyacetone and L-glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. EC 2.7.1.30.


A condition caused by occlusion of terminal aorta, the primary branches of the ABDOMINAL AORTA, as in aortoiliac obstruction. Leriche syndrome usually occurs in males and is characterized by IMPOTENCE, absence of a pulse in the femoral arteries, weakness and numbness in the lower back, buttocks, hips, and lower limbs.


Disorders, Sex Chromosome Abnormality
Disorders, Sex Chromosome
Sex Chromosome Disorders
Sex Chromosome Abnormality Disorders

Clinical conditions caused by an abnormal sex chromosome constitution (SEX CHROMOSOME ABERRATIONS), in which there is extra or missing sex chromosome material (either a whole chromosome or a chromosome segment).


Closed Reduction, Fracture
Closed Fracture Reduction

A procedure in which normal alignment of a fractured bone is restored by ORTHOPEDIC MANIPULATION without incision.


An endocrine state in men, characterized by a significant decline in the production of TESTOSTERONE; DEHYDROEPIANDROSTERONE; and other hormones such as HUMAN GROWTH HORMONE. Andropause symptoms are related to the lack of androgens including DEPRESSION, sexual dysfunction, and OSTEOPOROSIS. Andropause may also result from hormonal ablation therapy for malignant diseases.


Dermatitis, Contact, Allergic
Dermatitis, Allergic Eczematous
Allergic Contact Dermatitis
Dermatitis, Allergic Contact

A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.


Niemann-Pick Diseases
Niemann-Pick Disease

A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.


The underlying rationale or theoretical basis for the principles of NURSING.


Bathrooms
Lavatories
Restrooms
Latrines
Toilet Facilities

Facilities containing equipment for disposal of human excrement, often with an accompanying hand-washing station.


One of the largest genera of PARROTS, ranging from South American to Northern Mexico. Many species are commonly kept as house pets.


Subtraction Technique
Subtraction Technic

Combination or superimposition of two images for demonstrating differences between them (e.g., radiograph with contrast vs. one without, radionuclide images using different radionuclides, radiograph vs. radionuclide image) and in the preparation of audiovisual materials (e.g., offsetting identical images, coloring of vessels in angiograms).


The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.


Cyclic Somatostatin
Stilamin
SRIH-14
Somatotropin Release-Inhibiting Factor
Somatostatin
Somatostatin, Cyclic
Somatotropin Release-Inhibiting Hormone
Somatofalk
Somatostatin-14

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.


Cytochrome P-450 CYP2C19 Inhibitors
CYP2C19 Inhibitors
P450 CYP2C19 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19.


Cyclothymic Disorder
Cyclothymic Personality

An affective disorder characterized by periods of depression and hypomania. These may be separated by periods of normal mood.


A plant genus of the family OROBANCHACEAE. Lacking chlorophyll, they are nonphotosynthetic parasitic plants. The common name is similar to Broom or Scotch Broom (CYTISUS) or Butcher's Broom (RUSCUS) or Desert Broom (BACCHARIS) or Spanish Broom (SPARTIUM) or Brome (BROMUS).


Histiocytosis, Sea-Blue
Sea-Blue Histiocyte Disease
Sea-Blue Histiocytosis
Histiocyte Syndromes, Sea Blue
Histiocyte Syndrome, Sea Blue
Sea Blue Histiocytosis
Sea-Blue Histiocyte Syndrome

A congenital disease caused by an inborn error involving APOLIPOPROTEINS E leading to abnormal LIPID METABOLISM and the accumulation of GLYCOSPHINGOLIPIDS, particularly SPHINGOMYELINS in the HISTIOCYTES. This disorder is characterized by SPLENOMEGALY and the sea-blue histiocytes in the spleen and bone marrow after May Grunwald staining.


A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE


Beverages prepared from an infusion of plant tissues.


A 7-carbon keto sugar having the mannose configuration.


Aftereffect, Figural
Figural Aftereffect

A perceptual phenomenon used by Gestalt psychologists to demonstrate that events in one part of the perceptual field may affect perception in another part.


Cytoreduction Surgical Procedures
Cytoreductive Surgery
Cytoreductive Surgical Procedures
Debulking Surgical Procedures

Operative procedures carried out to reduce a mass of tissue, for example, to reduce the total amount of tissue composing a tumor.


Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part
Alveolar Soft Part Sarcoma

A variety of rare sarcoma having a reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue. It is a rare tumor, usually occurring between 15 and 35 years of age. It appears in the muscles of the extremities in adults and most commonly in the head and neck regions of children. Though slow-growing, it commonly metastasizes to the lungs, brain, bones, and lymph nodes. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1365)


Leader Sequences, mRNA
5' Untranslated Regions
5'UTR
5' UTR
Leader mRNA Sequences
mRNA Leader Sequences

The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.


Tape Recordings
Tape Recording
Audiotapes

Recording of information on magnetic or punched paper tape.


Abscisic Acid Monoammonium Salt, (R)-Isomer

2,4-Pentadienoic acid, 5-(1-hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl)-3-methyl-, (S-(Z,E))-

Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.


ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.


Trinitrobenzenesulfonic Acid, Sodium Salt

A reagent that is used to neutralize peptide terminal amino groups.


Hospital Food Service
Food Service, Hospital
Service, Hospital Food

Hospital department that manages and supervises the dietary program in accordance with the patients' requirements.


Medicine, Sports
Medicine, Sport
Sport Medicine
Sports Medicine

The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.


Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency

Deficiency of Guanine Phosphoribosyltransferase

Juvenile Gout, Choreoathetosis, Mental Retardation Syndrome

Choreoathetosis Self-Mutilation Hyperuricemia Syndrome

Deficiency of Hypoxanthine Phosphoribosyltransferase

Total Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency

Complete Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

Hypoxanthine Guanine Phosphoribosyltransferase Deficiency

An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)


Dentin formed by normal pulp after completion of root end formation.


Fat-Restricted Diet
Diet, Low-Fat
Diet, Fat-Restricted
Diet, Fat-Free

A diet that contains limited amounts of fat with less than 30% of calories from all fats and less than 10% from saturated fat. Such a diet is used in control of HYPERLIPIDEMIAS. (From Bondy et al, Metabolic Control and Disease, 8th ed, pp468-70; Dorland, 27th ed)


HIN Recombinational Enhancer Binding Protein

Factor For Inversion Stimulation Protein

A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. The protein plays a role in regulating DNA topology and activation of RIBOSOMAL RNA transcription. It was originally identified as a factor required for inversion stimulation by the Hin recombinase of SALMONELLA and Gin site-specific recombinase of BACTERIOPHAGE MU.


Double Refraction
Birefraction
Birefringence

The property of nonisotropic media, such as crystals, whereby a single incident beam of light traverses the medium as two beams, each plane-polarized, the planes being at right angles to each other. (Cline et al., Dictionary of Visual Science, 4th ed)


Inhibition (Psychology)
Inhibition, Psychology
Psychological Inhibition
Inhibition, Psychological

The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process.


Integumentary System Physiological Phenomenon Concepts

Integumentary System Physiological Phenomena

The properties and relationships and biological processes that characterize the nature and function of the SKIN and its appendages.


Exoglycosidases
Glycoside Hydrolases
Glycohydrolases
Endoglycosidases
Glycosidases


A beverage made from cow's milk fermented by LACTIC ACID-producing bacteria, especially LACTOCOCCUS LACTIS and LACTOBACILLUS BULGARICUS.


Children, Adult
Adult Daughters
Adult Offspring
Offspring, Adult
Adult Children
Adult Sons

Children who have reached maturity or the legal age of majority.


Picrorrhiza
Picrorhiza kurrooa
Picrorhiza

A plant genus of the family Plantaginaceae. Members contain scrosides (CINNAMATES) and phenylethanoid glycoside. P. kurrooa is the source of picroliv (a purified iridoid glycoside fraction from the roots having hepatoprotective, anti-inflammatory and antioxidant properties).


Weight Reduction Programs
Weight Loss Programs

Services providing counseling and activities that help overweight individuals to attain a more healthy body weight.


Ralstonia solanacearum
Pseudomonas solanacearum
Burkholderia solanacearum

A species of Ralstonia previously classed in the genera PSEUDOMONAS and BURKHOLDERIA. It is an important plant pathogen.


Galanin-2 Receptor
Receptor, Galanin, Type 2
Galanin Receptor 2
GALR2 Galanin Receptor

A galanin receptor subtype with broad specificity for full length GALANIN, galanin peptide fragments and GALANIN-LIKE PEPTIDE.


Blood Coagulation Factor V
Factor Pi
Proaccelerin
Coagulation Factor V
Factor V
Factor Five
AC Globulin
Factor 5

Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.


A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.


Bedridden Patients
Person, Non-Mobile
Bedridden Persons

Persons unable or unwilling, or otherwise incapacitated and not able to leave the bed due to physical or mental conditions.


Undecylenic Acids
Undecylenic Acid Dervatives
Undecylenates

Salts and derivatives of undecylenic acid.


HLA Class I Histocompatibility Antigen, B-38 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*38 allele family.


alpha-Adrenergic Receptors
Receptors, alpha-Adrenergic
Receptor, Adrenergic, alpha
Adrenergic alpha-Receptors
Receptors, Adrenergic, alpha

One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.


Antiparasitic Drugs
Parasiticides
Antiparasitics
Antiparasitic Agents

Drugs used to treat or prevent parasitic infections.


Karyometric Image Analysis
Karyometry
Karyometric Analysis

Microscopic study of the spacial distribution pattern of CHROMATIN in CELL NUCLEI and CELL NUCLEOLI.


Heterogeneous Nuclear Ribonucleoprotein A1

A heterogeneous ribonucleoprotein that contains an RNA-BINDING MOTIF and has poly(ADP)ribose-binding capability. It functions in the packaging of pre-mRNA into hnRNP particles for export to the cytoplasm and may play a role in RNA SPLICING site selection.


dsRBD
dsRBM
Double-Stranded RNA Binding Domain
Double-Stranded RNA Binding Motif

An RNA-binding motif characterized by an alpha-beta-beta-beta-alpha fold that binds DOUBLE-STRANDED RNA. It occurs in many eukaryotic proteins as well as in bacterial and viral proteins.


Occlusion, Centric Dental
Dental Occlusion, Centric
Centric Dental Occlusion

Contact between opposing teeth during a person's habitual bite.


Parry-Romberg Disease
Romberg's Disease
Progressive Hemifacial Atrophy
Romberg Hemi-Facial Atrophy
Romberg Disease
Facial Hemiatrophy of Romberg
Parry-Romberg Syndrome
Hemifacial Atrophy
Facial Hemiatrophy
Progressive Facial Hemiatrophy
Hemifacial Atrophy, Progressive

A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.


Aversion Therapy
Therapy, Aversive
Aversive Therapy
Therapy, Aversion

A treatment that suppresses undesirable behavior by simultaneously exposing the subject to unpleasant consequences.


Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.


Zonula Occludens-2 Protein
Zonula Occludens-2 Protein Isoform C1
Zonula Occludens-2 Protein Isoform A1
Zona Occludens 2 Protein
Tight Junction Protein 2

A zonula occludens protein subtype found in epithelial cell junctions. Several isoforms of zonula occludens-2 protein exist due to use of alternative promoter regions and alternative mRNA splicings.


A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)


A term used in Eastern European research literature for the functional neural unit that provides the basis for differential sensitivity; the analyzer consists of receptor, afferent nerves, and their central connections. (From Campbell's Psychiatric Dictionary, 8th ed.)


The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.


Prolonged dry periods in natural climate cycle. They are slow-onset phenomena caused by rainfall deficit combined with other predisposing factors.


Re-Irradiation
Re Irradiation
Reirradiation

Treatment in which a repeat course of RADIOTHERAPY is administered.


Receptors, Interleukin-1
IL-1 Receptors
IL1 Receptors
Receptors, IL-1
Interleukin 1 Receptor
Interleukin-1 Receptors

Cell surface receptors that are specific for INTERLEUKIN-1. Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. Signaling from interleukin-1 receptors occurs via interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88.


Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.


Grass, Barnyard
Echinochloa
Millet, Barnyard
Millet, Japanese
Grass, Cockspur

A plant genus of the family POACEAE that is grown mainly as a hay crop.


Multiprotein Complexes
Macromolecular Protein Complexes

Macromolecular complexes formed from the association of defined protein subunits.


DUSP Phosphatases
Dual-Specificity Phosphatases
Dual-Specificity Phosphatase

A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.


Alphabaculovirus
Nucleopolyhedroviruses
Gammabaculovirus
Deltabaculovirus
Nucleopolyhedrovirus
Nuclear Polyhedrosis Virus

Genera of the family BACULOVIRIDAE, characterized by the formation of crystalline, polyhedral occlusion bodies in the host cell nucleus. Nucleopolyhedrovirus is the common name for viruses from the Alphabaculovirus, Deltabaculovirus, or Gammabaculovirus genera.


Enzymes that hydrolyze GTP to GDP. EC 3.6.1.-.


Erythrocebus patas
Monkey, Patas
Patas Monkey
Monkey, Red
Red Monkey

A species of the genus ERYTHROCEBUS, subfamily CERCOPITHECINAE, family CERCOPITHECIDAE. It inhabits the flat open arid country of Africa. It is also known as the patas monkey or the red monkey.


Young's Modulus
Modulus of Elasticity
Elastic Modulus
Young Modulus

Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.


Outer Auditory Hair Cells
Cochlear Outer Hair Cells
Auditory Hair Cells, Outer
Outer Hair Cells
Hair Cells, Auditory, Outer
Auditory Hair Cell, Outer
Cochlear Outer Hair Cell
Hair Cells, Auditory, Outer Inner
Outer Auditory Hair Cell
Hair Cell, Auditory, Outer

Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.


Semilunar Ganglion
Gasser's Ganglion
Trigeminal Ganglia
Gasserian Ganglion
Trigeminal Ganglion

The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.


A plant genus of the family ASTERACEAE. Some species of the CHRYSANTHEMUM and the old Pyrethrum genera have been reclassified to this genus. The common name of tansy usually refers to this but also forms part of the common name of other plants such as Tansy Ragwort (SENECIO) and Tansyaster (HAPLOPAPPUS).


Polyneuropathy, Inflammatory Demyelinating, Chronic

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)


Telecommunications, Satellite
Satellite Communications
Communication, Satellite

Communications using an active or passive satellite to extend the range of radio, television, or other electronic transmission by returning signals to earth from an orbiting satellite.


Deltaretrovirus Infections
HTLV-BLV Infections
HTLV Infections
BLV Infections

Infections caused by the HTLV or BLV deltaretroviruses. They include human T-cell leukemia-lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED).


Antigens, CD126
CD126 Receptor
CD126 Antigens
Interleukin-6 Receptor alpha Subunit

A low affinity interleukin-6 receptor subunit that combines with the CYTOKINE RECEPTOR GP130 to form a high affinity receptor for INTERLEUKIN-6.


A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.


Utilization Review, Drug
Drug Utilization Evaluation
Evaluation, Drug Utilization
Drug Utilization Review
Drug-Use Review
Review, Drug Utilization
Review, Drug-Use

Formal programs for assessing drug prescription against some standard. Drug utilization review may consider clinical appropriateness, cost effectiveness, and, in some cases, outcomes. Review is usually retrospective, but some analysis may be done before drugs are dispensed (as in computer systems which advise physicians when prescriptions are entered). Drug utilization review is mandated for Medicaid programs beginning in 1993.


Bacterin
Bacterial Vaccines
Bacterial Vaccine
Vaccine, Bacterial
Vaccines, Bacterial

Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.


Heterotopic Ossification
Pathologic Ossification
Ossification, Ectopic
Ossification, Pathologic
Ossification, Pathological
Ossification, Heterotopic
Ectopic Ossification

The development of bony substance in normally soft structures.


An aspect of protein kinase (EC 2.7.1.37) in which serine residues in protamines and histones are phosphorylated in the presence of ATP.


Splenorenal Shunt, Surgical
Shunt, Surgical Splenorenal
Surgical Splenorenal Shunt
Splenorenal Shunt

Anastomosis of splenic vein to renal vein to relieve portal hypertension.


A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors (RECEPTORS, EICOSANOID).


Effect Modifier, Epidemiologic
Epidemiologic Effect Modifier
Hawthorne Effect
Modifiers, Epidemiologic Effect
Conditional Variables
Halo Effect
Effect Modifiers, Epidemiologic
Interviewer Effect
Moderator Variables
Epidemiologic Effect Modifiers

Factors that modify the effect of the putative causal factor(s) under study.


Lithocholic Acid
Lithocholate
Isolithocholic Acid

A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.


Bunion, Tailor's
Bunionette
Tailor's Bunion

Abnormal swelling of the outer aspect of the fifth metatarsal head affecting the fifth METATARSOPHALANGEAL JOINT.


A direct communication system, usually telephone, established for instant contact. It is designed to provide special information and assistance through trained personnel and is used for counseling, referrals, and emergencies such as poisonings and threatened suicides.


The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.


Cytochrome P450 Family 2
CYP2 Enzymes
CYP2 Family

A cytochrome P450 enzyme family that includes members which function in the metabolism of STEROIDS; COUMARINS; and NICOTINE.


Fibroblast Growth Factor Soluble Receptor 1

Receptor, Fibroblast Growth Factor, Type 1

A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.


Chromosomes, Human, Pair 13
Chromosome 13

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.


Postoperative Cognitive Dysfunction
Postoperative Cognitive Complications
Postoperative Decline

COGNITIVE IMPAIRMENT or functional decline after a surgical procedure.


Dermatophyte Infection
Fungal Skin Diseases
Dermatomycoses
Skin Diseases, Fungal
Dermatomycosis

Superficial infections of the skin or its appendages by any of various fungi.


Inflammation of the mediastinum, the area between the pleural sacs.


Suborder of dog-like carnivores which include dogs, coyotes, skunks, mustelids, walruses, seals, bears, and procyonids.


Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.


Substances of fungal origin that have antigenic activity.


Histidyl-tRNA Synthetase
Histidine-tRNA Ligase
His-tRNA Ligase
Jo-1 Antigen
Histidyl T RNA Synthetase

An enzyme that activates histidine with its specific transfer RNA. EC 6.1.1.21.


A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506) and SIROLIMUS.


Collections of information resources relevant to NURSING.


Peptidyl-Prolyl Cis-Trans Isomerase Pin4

Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4

A NIMA-interacting peptidylprolyl isomerase. It binds to double-stranded DNA and functions in the biogenesis of RIBOSOMES.


Therapeutic Research
Therapeutic Human Experimentation
Research, Therapeutic
Human Experimentation, Therapeutic

Human experimentation that is intended to benefit the subjects on whom it is performed.


The granting of a license to practice dentistry.


A nonsteroidal anti-inflammatory agent with analgesic properties used in the treatment of RHEUMATISM and ARTHRITIS.


Crystallins, alpha B Chain
alpha-Crystallin, B Subunit
Rosenthal Fiber Component
alpha-Crystallin B Chain
alpha B-Crystallin

One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.


VERTEBRATES belonging to the class amphibia such as frogs, toads, newts and salamanders that live in a semiaquatic environment.