Paranasal Sinus-Nasal Cavity Esthesioneuroblastoma

Esthesioneuroblastoma, Paranasal Sinus-Nasal Cavity

A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)


Ralozam D-65MT Kalma Esparon Apo-Alpraz Tafil Novo-Alprazol Xanax Cassadan Nu-Alpraz Trankimazin Alprox Alprazolan U-31,889 Alprazolam

A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)


FSH, human (follicle stimulating hormone)

A major gonadotropin secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and the LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. The alpha subunit is common in the three human pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.


Antinematodal benzimidazole used in veterinary medicine.


Magnification, Radiographic
Radiographic Magnification

Use of optic and geometric techniques to enhance radiographic image quality and interpretation. It includes use of microfocal X-ray tubes and intensifying fluoroscopic screens.


Polymerase Chain Reaction, Reverse Transcriptase

Reverse Transcriptase Polymerase Chain Reaction

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.


Diffuse Axonal Brain Injury
Diffuse Brain Injury
Brain Injuries, Diffuse
Diffuse Cerebral Injuries

Brain injuries occurring over a wide area instead of specific focal area.


A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.


An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.


beta-Activin
beta-Inhibin
Inhibin-beta Subunits
Activin-beta Subunits
beta-Activin Polypeptide
beta-Inhibin Polypeptide

They are glycopeptides and subunits in INHIBINS and ACTIVINS. Inhibins and activins belong to the transforming growth factor beta superfamily.


Insulae Terminalis
Islets of Calleja
Islands of Calleja
Island of Calleja Magna
Islands of Calleja Complex

Aggregations of GRANULE CELLS in the dorsal aspect of the OLFACTORY TUBERCLE and within the Island of Calleja Magna that lies between the BRAIN SEPTUM and the NUCLEUS ACCUMBENS.


Encephalomyelitis, Ovine
Ovine Encephalomyelitis
Visna

Demyelinating leukoencephalomyelitis of sheep caused by the VISNA-MAEDI VIRUS. It is similar to but not the same as SCRAPIE.


The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.


Tooth, Wisdom
Teeth, Wisdom
Molar, Third

The aftermost permanent tooth on each side in the maxilla and mandible.


Extracorporeal Life Support
ECLS Treatment
ECMO Treatment
Extracorporeal Membrane Oxygenation
Oxygenation, Extracorporeal Membrane

Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of SMOKE INHALATION INJURY; RESPIRATORY FAILURE; and CARDIAC FAILURE.


Administration of a vaccine to large populations in order to elicit IMMUNITY.


Luteinizing Hormone, beta Polypeptide Chain

The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.


A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.


Cloning Vectors
Shuttle Vectors
Genetic Vectors
Vectors, Genetic

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.


Activities associated with the disposition of the dead. It excludes cultural practices such as FUNERAL RITES.


Interleukin 12a
IL-12p35
Interleukin-12 Subunit p35
Interleukin-12 p35

A subunit of interleukin-12. It binds to the INTERLEUKIN-12 SUBUNIT P40 via a disulfide bond that results in the active cytokine.


The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Surgical anastomosis of the pancreatic duct, or the divided end of the transected pancreas, with the jejunum. (Dorland, 28th ed)


The family of true toads belonging to the order Anura. The genera include Bufo, Ansonia, Nectophrynoides, and Atelopus.


Iridoid Glycosides
Iridoidglycosides
Secoiridoid Glycosides

A subclass of iridoid compounds that include a glycoside moiety, usually found at the C-1 position.


Multiple Treatment Comparison Meta-Analysis

Meta-analysis of randomized trials in which estimates of comparative treatment effects are visualized and interpreted from a network of interventions that may or may not have been evaluated directly against each other. Common considerations in network meta-analysis include conceptual and statistical heterogeneity and incoherence.


An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.


Hollow sacs of cells in LARVA that form adult structures in insects during BIOLOGICAL METAMORPHOSIS.


Gymnosperms Cycadophyta Cycadales Cycadopsida


Proto-Oncogene Protein bcl-3
c-bcl-3 Protein
B-Cell Lymphoma 3 Protein
Protein c-bcl-3
Proto-Oncogene Proteins c-bcl-3
BCL-3 Protein
BCL3 Protein

A member of the I kappa B family, B-cell lymphoma 3-encoded (bcl-3) protein is involved in the regulation of TRANSCRIPTIONAL ACTIVATION of NF-KAPPA B target genes.


Spanish American War
Spanish-American War, 1898

Conflict between Spain and the United States, arising out of Spanish policies in Cuba.


Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.


Dormileno Ethylbarbital Veronal Barbitone Diethylmalonylurea Medinal Barbital Diemal

A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.


The anatomical study of specific regions or parts of organisms, emphasizing the relationship between the various structures (e.g. muscles, nerves, skeletal, cardiovascular, etc.).


Raman Spectroscopy
Analysis, Raman Spectrum
Raman Spectrum Analysis
Spectrum Analysis, Raman
Raman Scattering
Raman Optical Activity Spectroscopy

A plot of the difference in intensities between Raman scattered light using right and left circularly polarized incident light (CIRCULAR DICHROISM).


The anterior of the three primitive cerebral vesicles of the embryonic brain arising from the NEURAL TUBE. It subdivides to form DIENCEPHALON and TELENCEPHALON. (Stedmans Medical Dictionary, 27th ed)


Myelopathy
Spinal Cord Diseases
Spinal Cord Disorders

Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.


A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)


Idiopathic Central Nervous System Hypersomnolence

A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)


Alkylated DNA Repair Protein AlkB Homolog 5

Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5

A dioxygenase and alkylation repair homolog  that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes.  It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA.


Equilibrative, Nitrobenzylmercaptopurine Riboside (NBMPR)-Insensitive Nucleoside Transporter

Solute Carrier-Family 29 (Nucleoside Transporters), Member 2

Nitrobenzylmercaptopurine Riboside (NBMPR)-Insensitive, Equilibrative Nucleoside Transporter

A subtype of equilibrative nucleoside transporter proteins that is insensitive to inhibition by 4-nitrobenzylthioinosine.


Hydrophiinae
Hydrophidae
Sea Snakes
Hydrophiidae

A subfamily of marine elapid snakes comprising about 50 species with flattened oar-like tails used as sculls. They are found mostly in the coastal waters of south Asia and Australia. The largest reach a length of almost 9 feet but most species are only about a third as long. They are all venomous. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp331-3; Moore: Poisonous Snakes of the World, 1980, p159)


CDw218a Antigens
IL1 Receptor-Related Protein
CDw218a Antigen
Interleukin 18 Receptor 1
Interleukin-18 Receptor alpha Subunit
Antigens, CDw218a
Interleukin-18 Receptor alpha Chain

A subunit of the interleukin-18 receptor that is responsible of extracellular binding of IL-18.


Intravenous Injections
Injections, Intravenous

Injections made into a vein for therapeutic or experimental purposes.


Dental Sacs
Sac, Dental
Follicle, Dental
Dental Sac
Sacs, Dental
Follicles, Dental
Dental Follicles
Dental Follicle

Dense fibrous layer formed from mesodermal tissue that surrounds the epithelial enamel organ. The cells eventually migrate to the external surface of the newly formed root dentin and give rise to the cementoblasts that deposit cementum on the developing root, fibroblasts of the developing periodontal ligament, and osteoblasts of the developing alveolar bone.


Protein-Proline Kinase
PDPK Enzymes
Proline-Directed Protein Kinase
Proline-Directed Protein Kinases

A subclass of protein serine-threonine kinases that phosphorylate proteins on a SERINE or THREONINE residue that is immediately preceding a PROLINE residue.


A group of elements that include SCANDIUM; YTTRIUM; and the LANTHANOID SERIES ELEMENTS. Historically, the rare earth metals got their name from the fact that they were never found in their pure elemental form, but as an oxide. In addition they were very difficult to purify. They are not truly rare and comprise about 25% of the metals in the earth's crust.


Clinical Chemistry Tests
Test, Clinical Chemistry
Chemistry Tests, Clinical
Tests, Clinical Chemistry
Clinical Chemistry Test
Chemistry Test, Clinical

Laboratory tests demonstrating the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease.


Leukotriene A4 Synthase
LTA4 Synthase
Leukotriene A4 Synthetase
Arachidonate 5-Lipoxygenase
Leukotriene A Synthase
5-Lipoxygenase
Arachidonic Acid 5-Lipoxygenase

An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.


CD195 Antigens
CKR5 Receptors
CC-CKR5
CCR5 Receptor
CC Chemokine Receptor 5
CCR5 Receptors
Antigens, CD195
Receptors, CCR5
Receptors, CKR5

CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.


An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)


Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.


Carboxypeptidase B
Protaminase
Procarboxypeptidase B

A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. The enzyme catalyzes the preferential cleavage of a C-terminal peptidyl-L-lysine or arginine. It was formerly classified as EC 3.4.2.2 and EC 3.4.12.3.


Pappataci Fever
Sandfly Fever
Phlebotomus Fever

Influenza-like febrile viral disease caused by several members of the BUNYAVIRIDAE family and transmitted mostly by the bloodsucking sandfly Phlebotomus papatasii.


Nursing care of the aged patient given in the home, the hospital, or special institutions such as nursing homes, psychiatric institutions, etc.


Glucagon-Like Peptide 1
GLP-1
Glucagon-Like Peptide-1

A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.


Entorhinal Cortex
Entorhinal Cortices
Entorhinal Area
Secondary Olfactory Cortex
Area Entorhinalis

Cerebral cortex region on the medial aspect of the PARAHIPPOCAMPAL GYRUS, immediately caudal to the OLFACTORY CORTEX of the uncus. The entorhinal cortex is the origin of the major neural fiber system afferent to the HIPPOCAMPAL FORMATION, the so-called PERFORANT PATHWAY.


Digestive System Abnormalities
Abnormalities, Digestive System

Congenital structural abnormalities of the DIGESTIVE SYSTEM.


Hamadryas
Papio hamadryas
Hamadryas Baboon

A species of baboon in the family CERCOPITHECIDAE, which has a well-studied trilevel social structure consisting of troops, bands, and clans.


Cortex Piriformis
Prepyriform Cortex
Pyriform Area
Prepyriform Region
Prepyriform Area
Prepiriform Cortex
Piriform Area
Pyriform Cortex
Piriform Cortex

An area of the olfactory cortex comprising the rostral half of the uncus of the PARAHIPPOCAMPAL GYRUS and the anterior PARAHIPPOCAMPAL GYRUS. It receives major afferents directly from the OLFACTORY BULB.


The non-susceptibility to infection of a large group of individuals in a population. A variety of factors can be responsible for herd immunity and this gives rise to the different definitions used in the literature. Most commonly, herd immunity refers to the case when, if most of the population is immune, infection of a single individual will not cause an epidemic. Also, in such immunized populations, susceptible individuals are not likely to become infected. Herd immunity can also refer to the case when unprotected individuals fail to contract a disease because the infecting organism has been banished from the population.


A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.


Health Care Economics and Organizations
Healthcare Economics and Organizations

The economic aspects of health care, its planning, and delivery. It includes government agencies and organizations in the private sector.


Cavity Preparation, Dental
Preparations, Dental Cavity
Dental Cavity Preparations
Dental Cavity Preparation
Preparation, Dental Cavity
Cavity Preparations, Dental

An operation in which carious material is removed from teeth and biomechanically correct forms are established in the teeth to receive and retain restorations. A constant requirement is provision for prevention of failure of the restoration through recurrence of decay or inadequate resistance to applied stresses. (Boucher's Clinical Dental Terminology, 4th ed, p239-40)


Compounds that include a single 2-methyl-1,3-butadiene (also known as isoprene) within their structure.


Glyburide
Neogluconin
HB-419
Euglucon 5
Glibenclamide
Diabeta
Maninil
Micronase
Euglucon N
Daonil
Glybenclamide
HB-420

An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.


Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.


Lymphocyte Count
Total Lymphocyte Count
Lymphocyte Number

The number of LYMPHOCYTES per unit volume of BLOOD.


Serine Transhydroxymethylase
Serine Hydroxymethylase
Allothreonine Aldolase
Serine Aldolase
Serine Hydroxymethyltransferase
Glycine Hydroxymethyltransferase
Threonine Aldolase

A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.


Proteins that contain an iron-porphyrin, or heme, prosthetic group resembling that of hemoglobin. (From Lehninger, Principles of Biochemistry, 1982, p480)


ras Proteins
Gene Products, ras
ras GTPases

Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.


Glands situated on each side of the prostate that secrete a fluid component of the seminal fluid into the urethra.


Arthroscopic Meniscectomy
Meniscal Resection
Meniscectomy


Proto-Oncogene Protein ets-1
Proto-Oncogene Protein c-ets-1
Ets-1 Transcription Factor
c-ets1 Transcription Factor
c-ets-1 Protein
Proto-Oncogene Proteins c-ets-1

An ets proto-oncogene protein expressed primarily in adult LYMPHOID TISSUE; BRAIN; and VASCULAR ENDOTHELIAL CELLS.


Fibroblast Intermediate Filament Proteins

Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.


Dental Technician
Technician, Dental
Technicians, Dental
Dental Technicians

Individuals responsible for fabrication of dental appliances.


Catalyzes the final step in the galactocerebroside biosynthesis pathway.


Rats, Inbred ACI
Rats, Inbred A x C 9935 Irish
Rats, ACI

An inbred strain of rat that is widely used in BIOMEDICAL RESEARCH. Applications include the study of spontaneous NEOPLASMS; CHRONIC KIDNEY DISEASES, and CONGENITAL ABNORMALITIES.


The inspection of one's own body, usually for signs of disease (e.g., BREAST SELF-EXAMINATION, testicular self-examination).


4-Fluorophenylalanine
para-Fluorophenylalanine
p-Fluorophenylalanine
p Fluorophenylalanine


The plant family of order Equisetales, class Equisetopsida (Sphenopsida), division Equisetophyta (Sphenophyta).


A long-chain fatty acid ester of carnitine which facilitates the transfer of long-chain fatty acids from cytoplasm into mitochondria during the oxidation of fatty acids.


Luria Nebraska Neuropsychological Battery

A series of tests designed to assess neuropsychological function. The battery is used to diagnose specific cerebral dysfunction and also to determine lateralization.


Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.


A form of analgesia accompanied by general quiescence and psychic indifference to environmental stimuli, without loss of consciousness, and produced by the combined administration of a major tranquilizer (neuroleptic) and a narcotic.


p-Acetamidophenol Acephen Anacin-3 Datril Paracetamol Hydroxyacetanilide Panadol Acetominophen APAP Algotropyl Tylenol Acamol Acetamidophenol Acetaco N-(4-Hydroxyphenyl)acetanilide N-Acetyl-p-aminophenol Acetaminophen p-Hydroxyacetanilide

Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.


ATPases that provide energy for the translocation of proteins across bacterial PLASMA MEMBRANES and THYLAKOID membranes, by the SEC TRANSLOCATION CHANNELS. SecA is a component of the bacterial preprotein translocase which is comprised of SecA, the SECYEG TRANSLOCON, and the accessory domain proteins SecD, SecF, YajC, and YidC.


Fetal Maturity, Functional
Fetal Organ Maturity

Functional competence of specific organs or body systems of the FETUS in utero.


One of several indole alkaloids extracted from Tabernanthe iboga, Baill. It has a complex pharmacological profile, and interacts with multiple systems of neurotransmission. Ibogaine has psychoactive properties and appears to modulate tolerance to opiates.


Specialists, Clinical Nurse
Nurse Specialists, Clinical
Nurse Clinicians
Nurse Specialist, Clinical
Clinical Nurse Specialists
Specialist, Clinical Nurse
Clinical Nurse Specialist

Registered nurses who hold Master's degrees in nursing with an emphasis in clinical nursing and who function independently in coordinating plans for patient care.


Keratitis, Dendritic
Keratitis, Furrow
Furrow Keratitis

A form of herpetic keratitis characterized by the formation of small vesicles which break down and coalesce to form recurring dendritic ulcers, characteristically irregular, linear, branching, and ending in knoblike extremities. (Dictionary of Visual Science, 3d ed)


Nitroblue Tetrazolium
Nitrotetrazolium Blue
Tetrazolium Nitroblue
Nitro-BT

Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.


Pneumonia of Calves, Enzootic
Enzootic Calf Pneumonia
Enzootic Pneumonia of Calves

Chronic endemic respiratory disease of dairy calves and an important component of bovine respiratory disease complex. It primarily affects calves up to six months of age and the etiology is multifactorial. Stress plus a primary viral infection is followed by a secondary bacterial infection. The latter is most commonly associated with PASTEURELLA MULTOCIDA producing a purulent BRONCHOPNEUMONIA. Sometimes present are MANNHEIMIA HAEMOLYTICA; HAEMOPHILUS SOMNUS and mycoplasma species.


Bacteriophage HK022
Enterobacteria phage HK022

A tentative species in the genus lambda-like viruses, family SIPHOVIRIDAE.


Enteral Feeding
Gastric Feeding Tubes
Tube Feeding
Force Feeding
Enteral Nutrition
Nutrition, Enteral

Nutritional support given via the alimentary canal or any route connected to the gastrointestinal system (i.e., the enteral route). This includes oral feeding, sip feeding, and tube feeding using nasogastric, gastrostomy, and jejunostomy tubes.


Transcription Factor E2F
E2F Transcription Factors
E2F Proteins

A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.


The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)


A type of SEBACEOUS GLAND located in the area surrounding the ANUS of some mammals such as dogs, cats, opossums, and guinea pigs.


Transient Receptor Potential Cation Channels

A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.


The functional hereditary units of HELMINTHS.


Nucleus Accumbens
Nucleus Accumbens Septi
Accumbens Nucleus

Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.


Campylobacteriosis
Infections, Campylobacter
Campylobacter Infections

Infections with bacteria of the genus CAMPYLOBACTER.


DNA Polymerase II
DNA Pol II
DNA-Dependent DNA Polymerase II
DNA Polymerase epsilon

A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents. EC 2.7.7.7.


An opening in the wall between the right and the left upper chambers (HEART ATRIA) of a fetal heart. Oval foramen normally closes soon after birth; when it fails to close the condition is called PATENT OVAL FORAMEN.


AAA+ Superfamily
AAA Superfamily
P-Loop NTPases
AAA Proteins

A large, highly conserved and functionally diverse superfamily of NTPases and nucleotide-binding proteins that are characterized by a conserved 200 to 250 amino acid nucleotide-binding and catalytic domain, the AAA+ module. They assemble into hexameric ring complexes that function in the energy-dependent remodeling of macromolecules. Members include ATPASES ASSOCIATED WITH DIVERSE CELLULAR ACTIVITIES.


Transplantation, Heart
Cardiac Transplantation
Grafting, Heart
Heart Transplantation
Transplantation, Cardiac

The transference of a heart from one human or animal to another.


Mammaplasty
Mammoplasty
Breast Reconstruction

Surgical reconstruction of the breast including both augmentation and reduction.


Bender-Gestalt Test
Bender Visual Motor Gestalt Test

A psychological test consisting of nine geometric designs on cards. The subject is asked to redraw them from memory after each one is presented individually.


Chlormadinone Acetate, (9 beta,10 alpha)-Isomer

An orally active synthetic progestational hormone used often in combinations as an oral contraceptive (CONTRACEPTIVES, ORAL).


Psychosomatic Medicine
Medicine, Psychosomatic

A system of medicine which aims at discovering the exact nature of the relationship between the emotions and bodily function, affirming the principle that the mind and body are one.


Amygdalase
Gentiobiase
Cellobiase
Cellobiases
Emulsion beta-D-Glucosidase
beta-Glucosidase

An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of GLUCOSE.


Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I

Pituitary Adenylate Cyclase-Activating Peptide Receptor Type I

A pituitary adenylate cyclase-activating peptide receptor subtype that is found in the HYPOTHALAMUS; BRAIN STEM; PITUITARY GLAND; ADRENAL GLAND; PANCREAS; and TESTES and has a high affinity only for PACAP.


Interleukin-4, 13 Receptor Shared Subunit

An interleukin receptor subunit with specificity for INTERLEUKIN-13. It dimerizes with the INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT to form the TYPE II INTERLEUKIN-4 RECEPTOR which has specificity for both INTERLEUKIN-4 and INTERLEUKIN-13. Signaling of this receptor subunit occurs through the interaction of its cytoplasmic domain with JANUS KINASES such as the TYK2 KINASE.


U.S. Office of the Assistant Secretary for Health Office of Research Integrity

United States Office of the Assistant Secretary for Health Office of Research Integrity

United States Office of Research Integrity

The office at the UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES that leads efforts for protecting human subjects in biomedical and behavioral research. It was created in 2000. It replaces the Office for Protection from Research Risks (OPRR), which was part of the National Institutes of Health (NIH) and had authority over NIH-funded research.


Shrimp, Palaemonid
Palaemonetes
Palaemonidae
Palaemonid Shrimp
Palaemon
Macrobrachium

Genus of freshwater shrimp in the family Palaemonidae.


Erythema Induratum
Bazin Disease
Tuberculosis Cutis Indurativa
Bazin's Disease

A type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis. It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent. It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves. The nodules may progress to form indurations, ulcerations, and scars.


Medical Device Regulation
Medical Equipment Legislation
Medical Device Legislation

Laws, statutes, and regulations pertaining to devices used in medicine.


Marijuana
Cannabis
Hemp
Hemp Plant
Marihuana
Cannabis indica
Ganja
Bhang
Cannabis sativa
Hashish

The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber.


Fibrin Fibrinogen Split Products
Antithrombin VI
Fibrin Fibrinogen Degradation Products
Fibrin Degradation Products

Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.


Radiography, Interventional
Interventional Radiography

Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.


Anesthesia, Rebreathing
Closed-Circuit Anesthesia
Anesthesia, Closed-Circuit

Inhalation anesthesia where the gases exhaled by the patient are rebreathed as some carbon dioxide is simultaneously removed and anesthetic gas and oxygen are added so that no anesthetic escapes into the room. Closed-circuit anesthesia is used especially with explosive anesthetics to prevent fires where electrical sparking from instruments is possible.


MEAT or flesh of a pig (Sus scrofa) used as food.


Plasma Factor VIII Complex
Factor VIII-Related Antigen
Factor VIIIR-RCo
von Willebrand Factor
Ristocetin-Willebrand Factor
von Willebrand Protein
Factor VIIIR-Ag
Ristocetin Cofactor

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.


Serotonergic Neurons
Serotoninergic Neurons

Neurons whose primary neurotransmitter is SEROTONIN.


Promyelocytic Leukemia Zinc Finger Protein

Zinc Finger and BTB Domain Containing 16 Protein

Promyelocytic Leukaemia Zinc Finger Protein

A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.


Iron Sulfur Proteins
Iron-Sulfur Proteins

A group of proteins possessing only the iron-sulfur complex as the prosthetic group. These proteins participate in all major pathways of electron transport: photosynthesis, respiration, hydroxylation and bacterial hydrogen and nitrogen fixation.


Eph Family Receptor Interacting Protein B1

A transmembrane domain containing ephrin that is specific for EPHB1 RECEPTOR; EPHB2 RECEPTOR and EPHB3 RECEPTOR. It is widely expressed in a variety of developing and adult tissues.


Labyrinth Supporting Cells
Supporting Cells, Labyrinth

Cells forming a framework supporting the sensory AUDITORY HAIR CELLS in the organ of Corti. Lateral to the medial inner hair cells, there are inner pillar cells, outer pillar cells, Deiters cells, Hensens cells, Claudius cells, Boettchers cells, and others.


Prostitutes
Sex Workers
Sex Worker
Sex Worker Clients

People who engage in occupational sexual behavior in exchange for economic rewards or other extrinsic considerations.


Conium maculatum
Poison Hemlock
Hemlock, Poison
Conium

Conium maculatum is a large toxic umbelliferous plant, which contains the alkaloid coniine which affects the nervous system. The dried, fully grown, unripe fruit has sedative, anodyne, and antispasmodic effects.


An NAPH-dependent cytochrome P450 enzyme that catalyzes the oxidation of the side chain of sterol intermediates such as the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol.


A plant genus of the family EUPHORBIACEAE. The trees contain hippomanin A and the latex is a skin irritant.


Granuloma of Larynx
Granuloma, Laryngeal
Laryngeal Granuloma

A tumor-like nodule or mass of inflammatory granulation tissue projecting into the lumen of the LARYNX.


Resource Allocation
Allocation of Resources
Allocative Efficiency

Optimal distribution of goods and services.


An early non-mammalian embryo that follows the MORULA stage. A blastula resembles a hollow ball with the layer of cells surrounding a fluid-filled cavity (blastocele). The layer of cells is called BLASTODERM.


Landfill Leachate
Chemical Water Pollutants
Water Pollutants, Chemical

Liquid produced when water percolates through landfill waste.


vpr Gene Products
Viral Protein R (vpr)
vpr Protein
Gene Products, vpr
Gene Product, vpr
Viral Protein R

Trans-acting proteins which accelerate retroviral virus replication. The vpr proteins act in trans to increase the levels of specified proteins. vpr is short for viral protein R, where R is undefined.


COP-I
COPI Protein
COPI
Coat Protein Complex I
COP-1

A protein complex comprised of COATOMER PROTEIN and ADP RIBOSYLATION FACTOR 1. It is involved in transport of vesicles between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS.


Acetobacter xylinum
Gluconacetobacter xylinus
Gluconacetobacter xylinum
Acetobacter xylinus

A species of acetate-oxidizing bacteria, formerly known as Acetobacter xylinum.


Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.


Coccidioides immitis Infection
Valley Fever
San Joaquin Valley Fever
Coccidioidomycosis

Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN.


A uroplakin subtype that heterodimerizes with UROPLAKIN IA to form a component of the asymmetric unit membrane found in urothelial cells.


A major dental enamel-forming protein found in mammals. In humans the protein is encoded by GENES found on both the X CHROMOSOME and the Y CHROMOSOME.


Abscess, Tubercular, Intracranial
Intracranial Tuberculoma
Tuberculoma, Intracranial

A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with SEIZURES, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as OPPORTUNISTIC INFECTIONS, but also occur in immunocompetent individuals.


14-carbon saturated monocarboxylic acids.


cis-9-Octadecenoic Acid
9-Octadecenoic Acid
Oleate
Oleic Acid

An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)


Deoxyribonucleases
Nucleases, DNA
Alkaline DNase
Desoxyribonucleases
DNase
DNAase
Acid DNase

Enzymes which catalyze the hydrolases of ester bonds within DNA. EC 3.1.-.


Assisted Circulation
Circulation, Assisted

Pumping that aids the natural activity of the heart. (Dorland, 27th ed)


SSEA Antigens
Stage-Specific Embryonic Antigen
Stage-Specific Embryonic Antigens

Cell-surface molecules that exhibit lineage-restricted patterns of expression during EMBRYONIC DEVELOPMENT. The antigens are useful markers in the identification of EMBRYONIC STEM CELLS.


Cholecystitis, Acalculous
Gallbladder Inflammation, Acalculous
Acalculous Gallbladder Inflammation
Acalculous Cholecystitis

Inflammation of the GALLBLADDER wall in the absence of GALLSTONES.


Syncytia
Giant Cells, Multinucleated
Giant Cells
Syncytium
Polykaryocytes
Multinucleated Giant Cells

Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.


Oxygen Inhalation Therapy
Inhalation Therapy, Oxygen
Therapy, Oxygen Inhalation

Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)


Fluorescence Resonance Energy Transfer
Forster Resonance Energy Transfer

A type of FLUORESCENCE SPECTROSCOPY using two FLUORESCENT DYES with overlapping emission and absorption spectra, which is used to indicate proximity of labeled molecules. This technique is useful for studying interactions of molecules and PROTEIN FOLDING.


Insulin, Semilente
Insulin, Long-Acting
Long-Acting Insulin

Insulin formulations that contain substances that retard absorption thus extending the time period of action.


Electrodes with an extremely small tip, used in a voltage clamp or other apparatus to stimulate or record bioelectric potentials of single cells intracellularly or extracellularly. (Dorland, 28th ed)


Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).


Pituitary Hormone-Release Inhibiting Hormones

Pituitary Hormone Release Inhibiting Hormones

Polypeptide hormones produced in the hypothalamus which inhibit the release of pituitary hormones. Used for PHRIH in general or for which there is no specific heading.


Investigational New Drug Applications
Investigational New Drug Application

An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)


Cytotoxic T-Lymphocytes
TC2 Cells
Cell-Mediated Lympholytic Cells
TC1 Cells
T-Lymphocytes, Cytotoxic

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.


Protein Tyrosine Phosphatase, Non-Receptor Type 3

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an amino-terminal FERM domain, an intervening region containing one or more PDZ domains, and a carboxyl-terminal phosphatase domain. Expression of this phosphatase subtype has been observed in BONE MARROW; fetal LIVER; LYMPH NODES; and T LYMPHOCYTES.


Legislation, Pharmacy
Pharmacy Legislation
Pharmacy Law

Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.


Platelet Glycoproteins
Platelet Membrane Glycoproteins
PM-GPs

Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.


Salmonella enterica serovar Typhi
Salmonella typhosa
Salmonella typhi

A serotype of SALMONELLA ENTERICA which is the etiologic agent of TYPHOID FEVER.


Spectrometry, Mass, Fast Atom Bombardment

Spectroscopy, Mass, Fast Atom Bombardment

Mass Spectrometry, Fast Atom Bombardment

Mass Spectroscopy, Fast Atom Bombardment

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.


Postmeiotic Segregation Increased-S. cerevisiae-2

A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.


Greasy Pig Disease
Epidermitis, Exudative, of Swine
Epidermitis, Exudative of Swine
Exudative Dermatitis of Swine

An acute generalized dermatitis of pigs which occurs from 5 to 35 days of age, characterized by sudden onset, with morbidity of 10 to 90% and mortality of 5 to 90%. The lesions are caused by Staphylococcus hyos but the bacterial agent is unable to penetrate the intact skin. Abrasions on the feet and legs or lacerations on the body frequently precede infection. In acute cases, a vesicular-type virus may be the predisposing factor. The causative organism is inhibited by most antibiotics. (Merck Veterinary Manual, 5th ed)


Human females as cultural, psychological, sociological, political, and economic entities.


A plant genus in the family BERBERIDACEAE. The common names of Barberry or Oregon Grape are also used for MAHONIA. The similar-named Bayberry is the unrelated MYRICA. Oregon Grape was classified by Pursh as a Berberis but Nuttall claimed it is different enough to call it a new genus, MAHONIA. Botanists insist on this name while horticulturists stay with Mahonia. They are shrubs with yellow wood and usually three-branched spines at the base of leafstalks. Flowers are yellow, six-petaled and fruit is a berry with one to several seeds. Members contain BERBERINE.


Decentralized transaction and data management technology providing security, anonymity and data integrity without any third party control of transactions. Related research is focused on improving aspects  regarding privacy and security. (From PLoS One. 2016 Oct 3;11(10):e0163477)


A branch of psychology in which there is collaboration between psychologists and physicians in the management of medical problems. It differs from clinical psychology, which is concerned with the diagnosis and treatment of behavior disorders.


Leptin
Obese Gene Product
Ob Protein
Obese Protein
Ob Gene Product

A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.


The bones of the free part of the upper extremity including the HUMERUS; RADIUS; and ULNA.


Oviducts, Mammalian
Fallopian Tubes
Uterine Tubes
Salpinges
Salpinx
Fallopian Tube

A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.


Higher plants that live primarily in terrestrial habitats, although some are secondarily aquatic. Most obtain their energy from PHOTOSYNTHESIS. They comprise the vascular and non-vascular plants.


The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.


Genealogy and Heraldry
Geneology and Heraldry
Heraldry and Genealogy
Heraldry

Descent of a person, family, or group from an ancestor and coats of arms and other armorial bearings associated with an ancestor.


T Cell Leukemia Virus II Antibodies, Human

Human T-Cell Leukemia Virus II Antibodies

Leukemia-Lymphoma Virus II Antibodies, Human T-Cell

T-Cell Leukemia Virus II Antibodies, Human

Human T Lymphotropic Virus II Antibodies

Human T Cell Leukemia Virus II Antibodies

Leukemia Lymphoma Virus II Antibodies, Human T Cell

Human T-Lymphotropic Virus II Antibodies

Antibodies reactive with the HTLV-II ANTIGENS.


Gardnerella vaginalis
Hemophilus vaginalis
Haemophilus vaginalis
Corynebacterium vaginale

A species in the genus GARDNERELLA previously classified as Haemophilus vaginalis. This bacterium, also isolated from the female genital tract of healthy women, is implicated in the cause of bacterial vaginosis (VAGINOSIS, BACTERIAL).


Psychogenic Parasitosis
Ekbom Dermatozoic Delusion
Dermatozoic Delusion
Ekbom Delusory Parasitosis
Ekbom Delusional Parasitosis
Delusional Parasitosis
Ekbom Psychogenic Parasitosis
Delusory Parasitosis

A delusional disorder of belief in infestation by insects or other parasites. This FORMICATION is typically accompanied by dermatological manifestation such as PRURITUS that may lead to self-mutilation in order to remove the perceived parasites. It can be either primary or secondary to a somatic or psychiatric condition.


Processes, Neoplastic
Neoplastic Processes

The pathological mechanisms and forms taken by tissue during degeneration into a neoplasm and its subsequent activity.


Geological formations consisting of underground enclosures with access from the surface.


A monoterpene cyclohexanol produced from mint oils.


Psychiatry, Preventive
Preventive Psychiatry

A discipline concerned with the prevention of mental illness and the promotion of mental health.


Marek's Disease Herpesvirus 2
Marek's Disease Virus Serotype 2
Herpesvirus 3, Gallid
Marek Disease Herpesvirus 2
Gallid Herpesvirus 3

A species in the genus MAREK'S DISEASE-LIKE VIRUSES, in the family HERPESVIRIDAE, infecting chickens.


Schizophrenia and Disorders with Psychotic Features

Schizophrenia Spectrum and Other Psychotic Disorders

Marked disorders of thought (delusions, hallucinations, or other thought disorder accompanied by disordered affect or behavior), and deterioration from a previous level of functioning. Individuals have one o more of the following symptoms: delusions, hallucinations, and disorganized speech. (from DSM-5)


Thymidine Kinase
Deoxythymidine Kinase
Deoxypyrimidine Kinase

An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.


A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.


Complement C3 Convertase, Classical Pathway

A serine protease that cleaves multiple COMPLEMENT 3 into COMPLEMENT 3A (anaphylatoxin) and COMPLEMENT 3B in the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. It is a complex of COMPLEMENT 4B and COMPLEMENT 2A (C4b2a).


Leucenine Leucaenine Mimosine Leucaenol Leucenol

3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.


Systematic Evolution of Ligands by Exponential Enrichment

A method of generating a large library of randomized nucleotides and selecting NUCLEOTIDE APTAMERS by iterative rounds of in vitro selection. A modified procedure substitutes AMINO ACIDS in place of NUCLEOTIDES to make PEPTIDE APTAMERS.


Students, Pharmacy
Student, Pharmacy
Pharmacy Students
Pharmacy Student

Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.


The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.


Active Transport, Cell Nucleus
Nuclear Import
Nuclear Export
Nucleocytoplasmic Transport
Nuclear Transport
Nucleo-cytoplasmic Transport

Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.


Medical Faculty
Faculty, Medical
Faculties, Medical
Medical Faculties

Teaching and administrative staff having academic rank in a medical school.


Basement Membrane Tumor Protein
Osteonectin
BM-40
BM 40 Protein
SPARC Glycoprotein

Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein, the acronym stands for Secreted Protein, Acidic and Rich in Cysteine.


Enteritis, Infectious, of Mink
Mink Viral Enteritis

A highly contagious parvovirus infection in mink, caused by MINK ENTERITIS VIRUS or the closely related FELINE PANLEUKOPENIA VIRUS or CANINE PARVOVIRUS. Transmission usually occurs by the fecal/oral route.


Adrenergic alpha-Receptor Agonists
alpha-Adrenergic Receptor Agonist
Adrenergic alpha-Receptor Agonist
Receptor Agonists, alpha-Adrenergic
alpha-Adrenergic Receptor Agonists
Receptor Agonists, Adrenergic alpha
Adrenergic alpha-Agonist
alpha-Adrenergic Agonists
Adrenergic alpha-Agonists
alpha-Adrenergic Agonist

Drugs that selectively bind to and activate alpha adrenergic receptors.


These compounds function as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. Include the pyrophosphates.


A plant genus of the order Lamiales, family Linderniaceae.


Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.


Incompetent Cervix
Cervix Incompetence
Uterine Cervical Incompetence

Incompetent UTERINE CERVIX is usually diagnosed in the second trimester of PREGNANCY. It is characterized by passive painless cervical dilation in the absence of UTERINE CONTRACTION; BLEEDING; INFECTION; and sometimes with the amniotic sac (AMNIOTIC MEMBRANE) bulging through the partially dilated cervix. Left untreated, this condition may lead to premature pregnancy loss, such as HABITUAL ABORTION.


Cellular Apoptosis Susceptibility Protein

A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and participates in their export into CYTOPLASM. It is also associated with the regulation of APOPTOSIS and microtubule assembly.


General or unspecified injuries involving the leg.


The N-acetyl derivative of galactosamine.


Leukemia-Lymphoma Virus II Antigens, Human T-Cell

Leukemia Lymphoma Virus II Antigens, Human T Cell

T-Cell Leukemia Virus II Antigens, Human

T Cell Leukemia Virus II Antigens, Human

Antigens associated with HUMAN T-LYMPHOTROPIC VIRUS 2.


Coagulation Factor Xa
Factor X, Activated
Blood Coagulation Factor X, Activated
Factor Xa
Autoprothrombin C
Activated Factor X
Factor 10A
Thrombokinase
Factor Ten A

Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.


Declaration of Helsinki
Helsinki Declaration

An international agreement of the World Medical Association which offers guidelines for conducting experiments using human subjects. It was adopted in 1962 and revised by the 18th World Medical Assembly at Helsinki, Finland in 1964. Subsequent revisions were made in 1975, 1983, 1989, and 1996. (From Encyclopedia of Bioethics, rev ed, 1995)


Dimethylallyltranstransferase
Geranylpyrophosphate Synthetase
Geranylgeranyl Pyrophosphate Synthetase
Dolichyl Phosphate Synthetase
Dimethylallyltransferase
Prenyltransferase
Nerylpyrophosphate Synthetase

An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.


BMP Receptors
Bone Morphogenetic Protein Receptors
Receptor, BMP
BMP Receptor

A family of CELL SURFACE RECEPTORS that bind BONE MORPHOGENETIC PROTEINS. They are PROTEIN-SERINE-THREONINE KINASES that mediate SIGNAL TRANSDUCTION PATHWAYS through SMAD PROTEINS.


Receptor, Amylin
Islet Amyloid Polypeptide Receptor
Amylin Receptors
Receptors, Islet Amyloid Polypeptide
Amylin Receptor
IAPP Receptor

G-protein coupled receptors that are formed through the dimerization of the CALCITONIN RECEPTOR with a RECEPTOR ACTIVITY-MODIFYING PROTEIN. Their affinity for ISLET AMYLOID POLYPEPTIDE is dependent upon which of several receptor activity-modifying protein subtypes they are bound to.


beta-Endorphin
beta-Endorphin (1-31)
Endorphin, beta

A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.


Invertebrate Hormones
Hormones, Invertebrate

Hormones produced by invertebrates, usually insects, mollusks, annelids, and helminths.


G-Box Binding Factors
GBF Transcription Factors

A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.


Latent Stage Syphilis
Syphilis, Latent Stage
Syphilis, Latent

The stage of syphilis that occurs following the primary (CHANCRE) and secondary stages. The patient is asymptomatic at the latent stage but remains seropositive for the SPIROCHETE.


Persons or entities that introduce a novel composition, device, or process, as well as improvements thereof.


Apolipoprotein A5
Apo A-V Protein
APOA5 Protein
ApoA-V Protein
Apolipoprotein A-V
Apo A5 Protein

A minor apolipoprotein that associates with HIGH-DENSITY LIPOPROTEINS (HDL), VERY-LOW-DENSITY LIPOPROTEINS (VLDL), and CHYLOMICRONS. It regulates levels of plasma TRIGLYCERIDES by activating APOLIPOPROTEIN C-II LIPOPROTEIN LIPASE and inhibiting hepatic VLDL triglyceride hydrolysis.


Product of epinephrine O-methylation. It is a commonly occurring, pharmacologically and physiologically inactive metabolite of epinephrine.


Neuronal Protection
Neuron Protection
Neuroprotection
Neural Protection

The physiological processes and techniques used by the body to prevent neuronal injury and degeneration in the central nervous system following acute disorders or as a result of chronic neurodegenerative diseases.


Barosmin
Buchu Resin
Diosmin
Venosmine
Daflon

A bioflavonoid that strengthens vascular walls.


Immunofluorescence Antibody Test, Direct

A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)


Cytochrome P450, Family 1, Subfamily B, Polypeptide 1

A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. CYP1B1 has been shown to be physiologically important for FETAL DEVELOPMENT with mutations in the CYP1B1 gene resulting in congenital forms of GLAUCOMA and Peter's anomaly.


POU Domain, Class 4, Transcription Factor 1

A POU domain factor that activates GENETIC TRANSCRIPTION of GENES encoding NEUROFILAMENT PROTEINS; alpha internexin; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; and BCL-2 PROTO-ONCOGENE PROTEINS.


TCF Transcription Factors
T-Cell Factors
LEF Transcription Factors
Lymphoid Enhancer Factors

A family of DNA-binding proteins that are primarily expressed in T-LYMPHOCYTES. They interact with BETA CATENIN and serve as transcriptional activators and repressors in a variety of developmental processes.


Cytochrome c'
Cytochromes c Prime
Cytochromes c'
Ferricytochrome c'

A widely occurring subclass of c type cytochromes which function as electron carriers in the electron transport chain in photosynthetic and denitrifying BACTERIA.


Axonal Trigger Zone
Axon Initial Segments
Axon Hillock
Axon Initial Segment

First segment of axon that connects distal axon segments to the neuronal CELL BODY at the axon hillock region. The axon initial segment is not protected by the MYELIN SHEATH and has properties critical for axonal growth. The axon initial segment and the axon hillock form an axonal trigger zone.


Anorectics
Appetite Suppressants
Appetite-Suppressant Drugs
Anorectic Agents
Appetite Depressants
Appetite-Depressing Drugs
Anorexic Drugs
Anorexigenic Drugs

Agents that are used to suppress appetite.


The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.


Social Alienation
Alienation, Social
Social Breakdown Syndrome

The state of estrangement individuals feel in cultural settings that they view as foreign, unpredictable, or unacceptable.


8-Bromo Cyclic Adenosine Monophosphate, Monosodium Salt

8-Bromo Cyclic Adenosine Monophosphate, Sodium Salt

A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.


Tobacco Mosaic Virus Satellite
Satellite Tobacco Mosaic Virus
Tobacco mosaic satellite virus

A spherical RNA satellite virus which requires an obligatory helper TOBACCO MOSAIC VIRUS for replication.


Glutamine Phosphoribosyl Pyrophosphate Amidotransferase

An enzyme, involved in the early steps of purine nucleotide biosynthesis, that catalyzes the formation of 5-phosphoribosylamine from glutamine and phosphoribosylpyrophosphate. EC 2.4.2.14.


Wiskott-Aldrich Syndrome Protein
WASP Protein

WASP protein is mutated in WISKOTT-ALDRICH SYNDROME and is expressed primarily in hematopoietic cells. It is the founding member of the WASP protein family and interacts with CDC42 PROTEIN to help regulate ACTIN polymerization.


Neuroendocrine System
Neurosecretory Systems

A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.


Reagents and Indicators
Indicators
Indicators and Reagents
Reagents

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)


L-Cell Line
L Cells
L Cell Line
L-Cells
L Cells (Cell Line)
L-Cells, Cell Line

A cultured line of C3H mouse FIBROBLASTS that do not adhere to one another and do not express CADHERINS.


Carnivores of the genus Procyon of the family PROCYONIDAE. Two subgenera and seven species are currently recognized. They range from southern Canada to Panama and are found in several of the Caribbean Islands.


Gingko
Gingko biloba
Ginkgo biloba
Ginkgo
Ginkgophyta
Ginko
Maidenhair Tree

The only specie of the genus Ginkgo, family Ginkgoacea. It is the source of extracts of medicinal interest, especially Egb 761. Ginkgo may refer to the genus or species.


Protein Heteromultimerizaton
Protein Trimerization
Protein Dimerization
Protein Multimer Assembly
Protein Multimerization

The assembly of the QUATERNARY PROTEIN STRUCTURE of multimeric proteins (MULTIPROTEIN COMPLEXES) from their composite PROTEIN SUBUNITS.


Lymecycline
N-Lysinomethyltetracycline
Tetracycline-L-Methylene Lysine
Tetracyclinemethylene Lysine
Lymecycline Hydrochloride

A semisynthetic antibiotic related to TETRACYCLINE. It is more readily absorbed than TETRACYCLINE and can be used in lower doses.


HLA Class I Histocompatibility Antigen, B-8 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.


Circadian Rhythm
Diurnal Rhythm
Nyctohemeral Rhythm
Twenty-Four Hour Rhythm
Nycthemeral Rhythm

A circadian rhythm that is synchronized with the day-night cycle.


A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.


Topography, Moire
Moire Patterns
Moire Photographs
Moire Topography

A method of three-dimensional morphometry in which contour maps are produced from the overlapping interference fringes created when an object is illuminated by beams of coherent light issuing from two different point sources.


Ornithine Carbamoyltransferase
Ornithine Carbamylphosphate Transferase
Ornithine Transcarbamylase

A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.


Financial assistance for the impoverished elderly through public funding of programs, services, and individual income supplements.


Protoporphyrinogen Dehydrogenase
Protoporphyrinogen Oxidase
Protoporphyrinogen IX Oxidase
Protoporphyrinogenase
Protox

A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.


HuC Paraneoplastic Encephalomyelitis Antigen

A neural-specific RRM protein which contains three RNP-type RNA recognition motifs (RRMs). Human ELAVL3 is recognized by the anti-Hu serum antibody from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN). It also functions in neurogenesis.


Parvoviruses, Insect
Densovirus
Junonia coenia densovirus
Insect Parvoviruses


Nucleus Interpeduncularis
Interpeduncular Nucleus

A nucleus located at the midline of the ventral MIDBRAIN TEGMENTUM with primarily GABAergic projections to the median and dorsal raphe nuclei and the MIDBRAIN CENTRAL GRAY.


Cyclin-Dependent Kinase 3
Cell Division Protein Kinase 3
Cdk3 Protein Kinase

A cyclin-dependent kinase that forms a complex with CYCLIN C and is active during the G1 PHASE of the CELL CYCLE. It plays a role in the transition from G1 to S PHASE and in transcriptional regulation.


Aquaglyceroporins
Multi-Functional Aquaporins
Non-Specific Aquaporins

A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.


An acute necrotizing inflammation of the CECUM occurring in neutropenic patients.


Hemolytic Plaque Technic
Hemolytic Plaque Technique
Jerne's Plaque Technique
Jerne's Plaque Technic

A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)


Retinol Binding Proteins
Retinoid Binding Proteins
Retinol-Binding Proteins
Retinoid Binding Protein, F-Type

Proteins which bind with RETINOL. The retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of about 21 kDa. The retinol-protein complex (MW=80-90 kDa) circulates in plasma in the form of a protein-protein complex with prealbumin. The retinol-binding protein found in tissue has a molecular weight of 14 kDa and carries retinol as a non-covalently-bound ligand.


Dihydrostilbenes
Dihydrostilbenoids
Dihydrostilbene Derivatives

Organic compounds characterized by the functional group 1,2-dihydrostilbene.


A plant species of the family PHYTOLACCACEAE. The root has been used in traditional medicine and contains SAPONINS used to poison SNAILS.


Glomerular Visceral Epithelial Cells
Visceral Epithelial Cells, Glomerular
Podocytes
Epithelial Cells, Glomerular Visceral

Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.


cAMP-Dependent Protein Kinase, gamma-Catalytic Subunit

cAMP-Dependent Protein Kinase, alpha-Catalytic Subunit

cAMP-Dependent Protein Kinase, beta-Catalytic Subunit

Cyclic AMP-Dependent Protein Kinase Catalytic Subunits

Specific enzyme subunits that form the active sites of the type I and type II cyclic-AMP protein kinases. Each molecule of enzyme contains two catalytic subunits.


Molecular Docking Simulations
Molecular Docking Simulation
Molecular Docking Analysis

A computer simulation technique that is used to model the interaction between two molecules. Typically the docking simulation measures the interactions of a small molecule or ligand with a part of a larger molecule such as a protein.


Syndromic Surveillance
Biosurveillance Systems
Sentinel Surveillance
Sentinel Health Event

Monitoring of rate of occurrence of specific conditions to assess the stability or change in health levels of a population. It is also the study of disease rates in a specific cohort such as in a geographic area or population subgroup to estimate trends in a larger population. (From Last, Dictionary of Epidemiology, 2d ed)


Water containing no significant amounts of salts, such as water from RIVERS and LAKES.


Alternative Splicing
Nested Transcripts
RNA Splicing, Alternative
Alternate Splicing
Splicing, Alternative

Alternatively spliced RNA transcripts that are derived from a set of exons that are located in the middle of the primary transcript (RNA PRECURSORS), between unused exons.


Plagiocephaly, Positional
Plagiocephaly, Nonsynostotic
Plagiocephaly, Deformational
Nonsynostotic Plagiocephaly

A deformity of the SKULL that is not due to bone fusion (SYNOSTOSIS), such as craniosynostoses, and is characterized by an asymmetric skull and face. It is observed with an increased frequency in INFANTS after the adoption of supine sleeping recommendations to prevent SUDDEN INFANT DEATH SYNDROME.


A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.


Mesona Schizonepeta Tetradenia Micromeria Glechoma Leonotis Lamiaceae Labiatae

A plant genus. The distilled essential oil is approximately 1/3 borneol and 1/8 CAMPHOR.


Muscle Fatigue
Fatigue, Muscle
Muscular Fatigue

A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.


Medical Liability
Torts
Personal Liability
Professional Liability
Legal Liability
Institutional Liability
Liability, Legal

Accountability and responsibility to another, enforceable by civil or criminal sanctions.


Antigens, CD43
Leukosialin
Leukocyte Sialoglycoprotein
Sialophorin
CD43 Antigens
CD43 Antigen

A sialic acid-rich protein and an integral cell membrane mucin. It plays an important role in activation of T-LYMPHOCYTES.


Neoplasms, Bony Tissue
Bone Tissue Neoplasms
Neoplasms, Bone Tissue
Bony Tissue Neoplasms

Neoplasms composed of bony tissue, whether normal or of a soft tissue which has become ossified. The concept does not refer to neoplasms located in bones.


Poxvirus muris
Mousepox virus
Mouse Pox Virus
Ectromelia virus

A species of ORTHOPOXVIRUS infecting mice and causing a disease that involves internal organs and produces characteristic skin lesions.


Antiasthmatics
Antiasthmatic Drugs
Anti-Asthmatic Agents
Anti-Asthmatics
Anti-Asthmatic Drugs
Antiasthmatic Agents


HIV Proteinase
HTLV-III Protease
HIV Protease
p16 pol gene product, HIV
p16 protease, HIV

Enzyme of the human immunodeficiency virus that is required for post-translational cleavage of gag and gag-pol precursor polyproteins into functional products needed for viral assembly. HIV protease is an aspartic protease encoded by the amino terminus of the pol gene.


Polysaccharides consisting of mannose units.


A technique of closing incisions and wounds, or of joining and connecting tissues, in which staples are used as sutures.


Pseudonyms and Anonyms
Pseudonyms
Anonyms and Pseudonyms
Anonyms

Designations for persons whose names are not known or who wish to remain anonymous (anonyms) and for persons who wish to conceal or obscure their identity by assuming a fictitious name (pseudonyms).


Congocidine
Sinanomycin
Netropsin Hydrochloride
T-1384
Netropsin
IA-887

A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.


Skin Surface Microscopy
Epiluminescence Microscopy
Dermoscopy
Dermatoscopy

A noninvasive technique that enables direct microscopic examination of the surface and architecture of the SKIN.


NRF1 Transcription Factor
Nuclear Respiratory Factor 1

A transcription factor that controls the expression of variety of proteins including CYTOCHROME C and 5-AMINOLEVULINATE SYNTHETASE. It plays an important role in maintenance of the RESPIRATORY CHAIN of MITOCHONDRIA.


Second Sino-Japanese War 1937-1945
Sino-Japanese War 1937-1945
2nd Sino-Japanese War
Sino-Japanese War

Military conflict involving China and Japan 1937 - 1945.


Proposed as an adjuvant to cancer chemotherapy; may have radiation protective properties.


NF-E1 Erythroid-Specific Transcription Factor

Eryf1 Erythroid-Specific Transcription Factor

A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.


Pulmonary Infundibular Stenoses
Obstructive Subaortic Conus
Infundibular Stenoses, Pulmonary
Stenoses, Pulmonary Subvalvular
Stenosis, Subvalvular Pulmonary
Pulmonary Stenoses, Subvalvular
Stenosis, Pulmonary Subvalvular
Subvalvular Pulmonary Stenoses
Stenoses, Pulmonary Infundibular
Subvalvular Pulmonary Stenosis
Subvalvular Stenosis, Pulmonary
Infundibular Stenosis, Pulmonary
Pulmonary Subvalvular Stenoses
Pulmonary Stenosis, Subvalvular
Pulmonary Infundibular Stenosis
Stenoses, Subvalvular Pulmonary
Subvalvular Stenoses, Pulmonary
Pulmonary Subvalvular Stenosis
Stenosis, Pulmonary Infundibular

Narrowing below the PULMONARY VALVE or well below it in the infundibuluar chamber where the pulmonary artery originates, usually caused by a defective VENTRICULAR SEPTUM or presence of fibrous tissues. It is characterized by restricted blood outflow from the RIGHT VENTRICLE into the PULMONARY ARTERY, exertional fatigue, DYSPNEA, and chest discomfort.


Mice, Athymic
Nude Mice
Mouse, Nude
Mice, Nude
Mouse, Athymic
Athymic Mice

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.


Environmental Pollutants
Pollutants
Pollutants, Environmental

Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.


Onecut Transcription Factors
Onecut Homeodomain Proteins

A family of transcription factors that contain a single cut domain and a divergent homeodomain. They regulate gene networks by controlling the expression of other transcription factors and they play an important role in CELL DIFFERENTIATION and METABOLISM.


Angiotensin AT2 Receptor
Receptor, Angiotensin, Type 2
Angiotensin Type 2 Receptor
Receptor, Angiotensin II Type 2
Angiotensin II Type 2 Receptor

An angiotensin receptor subtype that is expressed at high levels in fetal tissues. Many effects of the angiotensin type 2 receptor such as VASODILATION and sodium loss are the opposite of that of the ANGIOTENSIN TYPE 1 RECEPTOR.


Pyorrhea Alveolaris
Periodontal Diseases
Parodontosis

Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.


Abortion, Therapeutic
Therapeutic Abortion

Abortion induced to save the life or health of a pregnant woman. (From Dorland, 28th ed)


Back to Work
Return to Work
Return-to-Work
Back-to-Work

Resumption of normal work routine following a hiatus or period of absence due to injury, disability, or other reasons.


Cellular Respiration
Respiration, Cell
Cell Respiration

The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.


Dystrophin-Related Protein 1
UTRN Protein
Dystrophin-Related Protein
Utrophin

An autosomally-encoded 376-kDa cytoskeletal protein that is similar in structure and function to DYSTROPHIN. It is a ubiquitously-expressed protein that plays a role in anchoring the CYTOSKELETON to the PLASMA MEMBRANE.


A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.


Quixin
Levofloxacin Anhydrous
Ofloxacin, (S)-Isomer
Levaquin
Levofloxacin


Cystic Fibrosis Transmembrane Conductance Regulator

A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)


Basic-Leucine Zipper Transcription Factors

A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.


Human papillomavirus type 18
HPV-18
Human papillomavirus 18

A type of human papillomavirus especially associated with malignant tumors of the genital and RESPIRATORY MUCOSA.


ASIC Channel
Acid Sensing Ion Channels
Proton-Gated Sodium Channels
Acid-Sensing Ion Channels

A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. They are AMILORIDE-sensitive and are implicated in the signaling of a variety of neurological stimuli, most notably that of pain in response to acidic conditions.


Pregnancy, Extrauterine
Pregnancy, Ectopic
Ectopic Pregnancy

A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).


Neoplasms by Site
Sites, Neoplasm
Neoplasms by Sites
Site, Neoplasm

A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.


A nursing specialty concerned with health and nursing care given to primary and secondary school students by a registered nurse.


Study of past events and development in the field of Nursing.


Monoglyceride Hydrolase
Glycerol Monoester Hydrolases
Monoglyceride Lipases
Monoacylglycerol Lipases
Monoglyceride Esterases

An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23.


Debrisoquine 4-Monooxygenase
Sparteine Monooxygenase
Cytochrome P450 2D6
CYP2D6
CYP 2D6
Cytochrome P-450 CYP2D6
Debrisoquine Hydroxylase
Debrisoquine 4-Hydroxylase
Imipramine 2-Hydroxylase

A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.


NSC-89671
Synergisidin
Ascotoxin
Decumbin
Cyanein
Brefeldin A

A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.


Protein Kinase C-epsilon
PKC epsilon
Protein Kinase C epsilon
PKC-epsilon Serine Threonine Kinase

A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.


Expulsion of milk from the mammary alveolar lumen, which is surrounded by a layer of milk-secreting EPITHELIAL CELLS and a network of myoepithelial cells. Contraction of the myoepithelial cells is regulated by neuroendocrine signals.


Combining Site
Binding Sites
Binding Site

The parts of a macromolecule that directly participate in its specific combination with another molecule.


Cesarean Section, Repeat
Repeat Cesarean Section

Extraction of the fetus by abdominal hysterotomy anytime following a previous cesarean.


Sermion
Nicergolin-Ratiopharm
Nicergolin Von Ct
Nimergoline
Fisifax
Nicergoline
Nicerium
Circo-Maren
Nicergobeta
Nicergolin Atid
F.I. 6714
Nicergolin-Neuraxpharm
Nicotergoline
Nicergolin Lindo
Ergobel
Nicergolin-TEVA

An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It may ameliorate cognitive deficits in CEREBROVASCULAR DISORDERS.


Burkholderia cepacia
Pseudomonas cepacia

A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.


Black Water Fever
Blackwater Fever
Malaria, Hemolytic

A complication of MALARIA, FALCIPARUM characterized by the passage of dark red to black urine.


Arthritis, Rheumatoid
Rheumatoid Arthritis

A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.


An inhibitor of glutamate decarboxylase and an antagonist of GAMMA-AMINOBUTYRIC ACID. It is used to induce convulsions in experimental animals.


Psychological Distress
Emotional Stress
Emotional Distress

Negative emotional state characterized by physical and/or emotional discomfort, pain, or anguish.


Diastolic Heart Failure
Heart Failure, Diastolic

Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.


Pedodontics
Dentistry, Pediatric
Pediatric Dentistry

The practice of dentistry concerned with the dental problems of children, proper maintenance, and treatment. The dental care may include the services provided by dental specialists.


25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).


beta-D-Mannosidase
manA protein (beta-Mannosidase)
beta-Mannanase
beta-Mannosidase

An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.


pADPr-Binding Proteins
Poly-ADP-Ribose Binding Proteins

Proteins that contain POLY-ADP RIBOSE BINDING MOTIFS. They include HISTONES and other proteins that function in DNA REPAIR, replication, gene transcription, and APOPTOSIS.


Legislation, Nursing
Nursing Legislation

Laws and regulations, pertaining to the field of nursing, proposed for enactment by a legislative body.


Albuterol-Ipratropium Drug Combination
Combivent Respimat
Albuterol, Ipratropium Drug Combination
Dey Combination
Albuterol-Ipratropium
Combivent

A combined pharmaceutical preparation of Ipratropium Bromide and Albuterol Sulfate that is used to treat the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE.


A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity.


Schizoid Personality Disorder
Schizoid Personality
Personality Disorder, Schizoid

A personality disorder manifested by a profound defect in the ability to form social relationships, no desire for social involvement, and an indifference to praise or criticism.


Crustecdysone Beta-Ecdysone Ecdysterone 20-Hydroxyecdysone

A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.


Fullterm Birth
Birth of Full-Term Infant
Birth of Full-Term Newborn
Term Birth

CHILDBIRTH at the end of a normal duration of PREGNANCY, between 37 to 40 weeks of gestation or about 280 days from the first day of the mother's last menstrual period.


Self-Examination, Breast
Breast Self-Examination

The inspection of one's breasts, usually for signs of disease, especially neoplastic disease.


Steroid delta(5)-3 beta-ol Dehydrogenase

An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of NAD. It converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. EC 1.1.1.145.


Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.


Used in the manufacture of acetophenetidin.


MMP20 Metalloproteinase
MMP-20 Metalloproteinase
Matrix Metalloproteinase 20
Enamelysin

A secreted matrix metalloproteinase that is the predominant proteolytic activity in the enamel matrix. The enzyme has a high specificity for dental enamel matrix protein AMELOGENIN.


A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.


Forced Expiratory Flow Rates
Flow Rates, Expiratory Forced
Expiratory Forced Flow Rates
Flow Rates, Forced Expiratory

The rate of airflow measured during a FORCED VITAL CAPACITY determination.


Plectin
Hemidesmosomal Protein HD1
500-kDa HD1 Protein

A cytoskeletal linker protein with a molecular weight of greater than 500 kDa. It binds INTERMEDIATE FILAMENTS; MICROTUBULES; and ACTIN CYTOSKELETON and plays a central role in the organization and stability of the CYTOSKELETON. Plectin is phosphorylated by CALMODULIN KINASE; PROTEIN KINASE A; and PROTEIN KINASE C.


Epidermal Cell Derived Thymocyte-Activating Factor

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.


Hospital Bed Capacity, 500 and over
Hospital Bed Capacity 500 Over

The number of beds 500 or more which a hospital has been designed and constructed to contain. It may also refer to the number of beds set up and staffed for use.


3 alpha,20 beta Hydroxysteroid Dehydrogenase

An enzyme that catalyzes the interconversion of a ketone and hydroxy group at C-20 of cortisone and other 17,20,21-trihydroxy steroids. EC 1.1.1.53.


A highly fatal contagious disease of goats and sheep caused by PESTE-DES-PETITS-RUMINANTS VIRUS. The disease may be acute or subacute and is characterized by stomatitis, conjunctivitis, diarrhea, and pneumonia.


A state of insufficient flesh on the body usually defined as having a body weight less than skeletal and physical standards. Depending on age, sex, and genetic background, a BODY MASS INDEX of less than 18.5 is considered as underweight.


Leishmania enriettii
Leishmania (Leishmania) enrietti
Leishmania (Leishmania) enriettii
Leishmania leishmania enriettii
Leishmania leishmania enrietti
Leishmania enrietti

A parasitic hemoflagellate of the subgenus Leishmania leishmania that has been found as a natural infection of the Brazilian guinea pig. Its host-tissue relationship is, in general, comparable to that of L. braziliensis.


Ikaros Transcription Factor
Ikaros Protein

A transcription factor that plays a role as a key regulator of HEMATOPOIESIS. Aberrant Ikaros expression has been associated with LYMPHOBLASTIC LEUKEMIA.


13,14-dihydroprostaglandin F2 alpha Synthetase

NADPH-dependent reductase that catalyzes the reduction of many carbonyl compounds including QUINONES; PROSTAGLANDINS; and XENOBIOTICS.


Intermittent Positive Pressure Breathing (IPPB)

Application of positive pressure to the inspiratory phase of spontaneous respiration.


Peptide Initiation Factor 2
Initiation Factor-2
Prokaryotic Initiation Factor-2
infB Gene Product
Peptide Initiation Factor IF-2
infB Protein
IF2 Protein
Translational Initiation Factor 2

The largest of the three prokaryotic initiation factors with a molecular size of approximately 80 kD. It functions in the transcription initiation process by promoting the binding of formylmethionine-tRNA to the P-site of the 30S ribosome and by preventing the incorrect binding of elongator tRNA to the translation initiation site.


Postabortion
After Care
Postabortal Programs
Aftercare
Follow-Up Care
After-Treatment

The care and treatment of a convalescent patient, especially that of a patient after surgery.


Hepatocyte Nuclear Factor 3-beta
Forkhead Box A2 Protein
Hepatocyte Nuclear Factor 3beta
HNF-3beta Protein

A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. Mutations in HNF-3beta have been associated with CONGENITAL HYPERINSULINISM.


The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM.


Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.


Idiopathic Orthostatic Hypotension, Shy-Drager Type

A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)


Islet Cell Tumor, Ulcerogenic
Gastrin-Producing Tumor
Gastrinoma
Ulcerogenic Islet Cell Tumor

A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).


Eye Gaze
Focusing, Ocular
Ocular Fixation
Fixation, Ocular

Positioning and accommodation of eyes that allows the image to be brought into place on the FOVEA CENTRALIS of each eye.


Uridine Pyrophosphate
UDP
Uridine Diphosphate

A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.


Hydroxymethylglutaryl CoA Reductase, NAD-Dependent

Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. This class of enzymes performs a catabolic role in microorganisms such as Pseudomonas mevalonii where it oxidatively acetylates MEVALONIC ACID to form 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A and NADH.


Critical Care Nursing
Intensive Care Nursing

A nursing specialty that deals specifically with the care of patients who are critically ill.


Metamorphosis, Biological
Biological Metamorphosis

Profound physical changes during maturation of living organisms from the immature forms to the adult forms, such as from TADPOLES to frogs; caterpillars to BUTTERFLIES.


Histoplasma capsulatum Infection
Histoplasmosis
Histoplasma Infection

Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.


A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.


Stealing of corpses after burial, especially for medical dissection. In the late 18th and early 19th centuries, in the absence of laws governing the acquisition of dissecting material for the study of anatomy, the needs of anatomy classes were met by surreptitious methods: body-snatching and grave robbing. (Random House Unabridged Dictionary, 2d ed; from Garrison, An Introduction to the History of Medicine, 4th ed, p447; from Castiglioni, A History of Medicine, 2d ed, p676)


Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2

A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.


Interleukin 1 Receptor Antagonist Protein

A synthetic form of native human IL-1Ra that has an additional methionine residue at its amino terminus.


Optic Tectum
Anterior Colliculus
Tectum, Optic
Optic Lobe, Mammalian
Superior Colliculus
Superior Colliculi
Colliculus, Superior
Optic Lobe, Human

The anterior pair of the quadrigeminal bodies which coordinate the general behavioral orienting responses to visual stimuli, such as whole-body turning, and reaching.


Ala-tRNA Ligase
Alanyl-tRNA Synthetase
Alanyl T RNA Synthetase
Alanine-tRNA Ligase

An enzyme that activates alanine with its specific transfer RNA. EC 6.1.1.7.


Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.


Histidine
Histidine, L-isomer
L-Histidine

An essential amino acid that is required for the production of HISTAMINE.


Mass Spectrometry-Mass Spectrometry
Tandem Mass Spectrometry

A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.


Myoclonic Epilepsy of Unverricht and Lundborg

Progressive Myoclonus Epilepsybaltic Myoclonic Epilepsy

Myoclonus Progressive Epilepsy of Unverricht and Lundborg

An autosomal recessive condition characterized by recurrent myoclonic and generalized seizures, ATAXIA, slowly progressive intellectual deterioration, DYSARTHRIA, and intention tremor. Myoclonic seizures are severe and continuous, and tend to be triggered by movement, stress, and sensory stimuli. The age of onset is between 8 and 13 years, and the condition is relatively frequent in the Baltic region, especially Finland. (From Menkes, Textbook of Child Neurology, 5th ed, pp109-110)


Cellulase
Endoglucanase E
beta-1,4-Glucan-4-Glucanohydrolase
Endoglucanase C
Endoglucanase IV
Endoglucanase A
Endoglucanase
Endoglucanase Y
Endo-1,4-beta-Glucanase
Cellulysin

An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.