A plant species of the family AQUIFOLIACEAE. It has been used to induce vomiting in purification rites.


2-Nicotinamidoethyl Nitrate
Dancor
2-Nicotinamidethyl Nitrate
SG-75
Ikorel
Nicorandil
Adancor

A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.


Myeloid Leukemia, Chronic, Chronic Phase

Granulocytic Leukemia, Chronic, Stable Phase

Granulocytic Leukemia, Chronic, Stable-Phase

Myelogenous Leukemia, Chronic, Chronic-Phase

Myeloid Leukemia, Chronic, Chronic-Phase

Myelogenous Leukemia, Chronic, Chronic Phase

The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.


Organizational Models
Models, Organizational

Theoretical representations and constructs that describe or explain the structure and hierarchy of relationships and interactions within or between formal organizational entities or informal social groups.


Retinal Bipolar Cells
Bipolar Cells, Retinal

INTERNEURONS of the vertebrate RETINA containing two processes. They receive inputs from the RETINAL PHOTORECEPTOR CELLS and send outputs to the RETINAL GANGLION CELLS. The bipolar cells also make lateral connections in the retina with the RETINAL HORIZONTAL CELLS and with the AMACRINE CELLS.


Alcohol Dehydrogenase
Alcohol Dehydrogenase (NAD+)
Alcohol Dehydrogenase I
Yeast Alcohol Dehydrogenase
Alcohol Dehydrogenase II
Alcohol-NAD+ Oxidoreductase

A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.


Associative Dysphasia
Dysphasia, Conduction
Aphasia, Conduction
Associative Aphasia
Dysphasia, Associative
Aphasia, Associative

A type of fluent aphasia characterized by an impaired ability to repeat one and two word phrases, despite retained comprehension. This condition is associated with dominant hemisphere lesions involving the arcuate fasciculus (a white matter projection between Broca's and Wernicke's areas) and adjacent structures. Like patients with Wernicke aphasia (APHASIA, WERNICKE), patients with conduction aphasia are fluent but commit paraphasic errors during attempts at written and oral forms of communication. (From Adams et al., Principles of Neurology, 6th ed, p482; Brain & Bannister, Clinical Neurology, 7th ed, p142; Kandel et al., Principles of Neural Science, 3d ed, p848)


Intrauterine devices that release contraceptive agents.


Uridine Monophosphate
Uridylic Acid
Uridine 5'-Monophosphate
Uridylic Acids
UMP

5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.


The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.


Excision Repair Cross-Complementing Rodent Repair Deficiency, Group 2 Protein

Xeroderma Pigmentosum Complementation Group D Protein

A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCLEOTIDE EXCISION REPAIR, and mutations in this protein are associated with XERODERMA PIGMENTOSUM.


A painful linear ulcer at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal. (Dorland, 27th ed & Stedman, 25th ed)


The upper part of the trunk between the NECK and the ABDOMEN. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)


Giant Viruses
Giruses
Megaviridae
Megavirales

DNA viruses that have genomes up to several megabases in length and infect primarily single-celled EUKARYOTES.


Gingival Fibromatosis
Fibromatosis, Gingival
Fibromatosis Gingivae

Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)


Filters, Inferior Vena Cava
Vena Cava Filters
Inferior Vena Cava Filters
Umbrella Filters
Filter, Inferior Vena Cava
Inferior Vena Cava Filter

Mechanical devices inserted in the inferior vena cava that prevent the migration of blood clots from deep venous thrombosis of the leg.


Vaccines, Live, Unattenuated
Live Unattenuated Vaccines
Vaccines, Unattenuated

Live vaccines prepared from microorganisms without their virulence altered. Examples include smallpox (vaccinia) and adenovirus vaccines.


Proto-Oncogene Protein vav
Proto-Oncogene Protein vav1
Proto-Oncogene Proteins c-vav
c-vav Protein
vav Proto-Oncogene Protein
Proto-Oncogene Protein c-vav
vav Guanine-Nucleotide Exchange Factor

Proteins that are guanine nucleotide exchange factors for RHO GTPASES. They contain pleckstrin homology and SH2 domains, through which they function as signal transducing adaptor proteins.


Ethyl Alcohol Abuse Neurologic Syndromes

Ethanol Induced Nervous System Disorders

Alcohol-Induced Disorders, Nervous System

Ethanol-Induced Disorders, Nervous System

Ethanol-Induced Nervous System Disorders

Nervous System Disorders, Ethanol-Induced

Acute and chronic neurologic disorders associated with the various neurologic effects of ETHANOL. Primary sites of injury include the brain and peripheral nerves.


The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.


Psychology, Educational
Educational Psychology

The branch of psychology concerned with psychological aspects of teaching and the formal learning process in school.


Cerebral Arterial Diseases
Arterial Diseases, Cerebral
Cerebral Artery Diseases

Pathological conditions of intracranial ARTERIES supplying the CEREBRUM. These diseases often are due to abnormalities or pathological processes in the ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; and POSTERIOR CEREBRAL ARTERY.


TRANSCRIPTION FACTORS that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.


United States Office of Technology Assessment

United States Congress Office of Technology Assessment

An office established to help Congress participate and plan for the consequences of uses of technology. It provided information on both the beneficial and adverse effects of technological applications. The Office of Technology Assessment closed on September 29, 1995.


Deficiency of Glucose-6-Phosphate Dehydrogenase

Glucose 6 Phosphate Dehydrogenase Deficiency

A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.


Psychological Retention
Retention (Psychology)
Retention, Psychology

The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.


Multisystemic Atrophy
Multiple System Atrophy Syndrome
Multisystem Atrophy
Multiple System Atrophy

A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)


Protective Clothing
Clothing, Protective

Clothing designed to protect the individual against possible exposure to known hazards.


Eye Diseases, Hereditary
Hereditary Eye Diseases

Transmission of gene defects or chromosomal aberrations/abnormalities which are expressed in extreme variation in the structure or function of the eye. These may be evident at birth, but may be manifested later with progression of the disorder.


A complex mixture of PHOSPHOLIPIDS; GLYCOLIPIDS; and TRIGLYCERIDES; with substantial amounts of PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; and PHOSPHATIDYLINOSITOLS, which are sometimes loosely termed as 1,2-diacyl-3-phosphocholines. Lecithin is a component of the CELL MEMBRANE and commercially extracted from SOYBEANS and EGG YOLK. The emulsifying and surfactant properties are useful in FOOD ADDITIVES and for forming organogels (GELS).


Graphic Medicine as Topic
Manga as Topic
Graphic Novels as Topic
Comic Books as Topic

Works about a literary genre that uses comics to tell personal stories of illness and health. (https://www.nlm.nih.gov/exhibition/graphicmedicine)


Spinal Epidural Hematoma
Hemorrhage, Spinal Epidural
Hematoma, Epidural, Spinal

A rare epidural hematoma in the spinal epidural space, usually due to a vascular malformation (CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS) or TRAUMA. Spontaneous spinal epidural hematoma is a neurologic emergency due to a rapidly evolving compressive MYELOPATHY.


Sphingomyelinase C
Sphingomyelin Cholinephosphohydrolase
Sphingomyelinase
Sphingomyelin Phosphodiesterase
Sphingomyelin Cleaving Enzyme

An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.


Programs or projects established by religious groups or institution to support and provide missionary activities, including sharing faith or providing educational, medical, or other assistance.


Vaccines or candidate vaccines used to prevent ANTHRAX.


Deconditioning, Cardiovascular
Cardiovascular Deconditioning

A change in cardiovascular function resulting in a reduction in BLOOD VOLUME, and reflex DIURESIS. It occurs frequently after actual or simulated WEIGHTLESSNESS.


Baccharis
Willow, Water
Broom, Desert
Water Willow

A plant genus of the family ASTERACEAE. Other plants called broom include CYTISUS; SPARTIUM; and BROMUS.


Arterial Occlusive Diseases
Arterial Obstructive Diseases

Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.


Cysteine Dioxygenase
Cysteine Oxidase
Cysteine Dioxygenase Type I

An enzyme that catalyzes the conversion of L-CYSTEINE to 3-sulfinoalanine (3-sulfino-L-alanine) in the CYSTEINE metabolism and TAURINE and hypotaurine metabolic pathways.


Hospital Chief Executive Officer
Chief Executive Officers, Hospital
Hospital CEO
Hospital Chief Executive Officers
CEO, Hospital
Chief Executive Officer, Hospital

Individuals who have the formal authority to manage a hospital, including its programs and services, in accordance with the goals and objectives established by a governing body (GOVERNING BOARD).


Diagnostic Screening Programs
Screening Programs, Diagnostic

Services for the presumptive identification of unrecognized disease in an apparently healthy, asymptomatic population by means of tests, examinations or other procedures that can be applied rapidly and easily to the target population. (from World Health Organization http://www.who.int/cancer/prevention/diagnosis-screening/screening/en/ Oct. 24,2017)


Transfer RNA, Phe
RNA, Transfer, Phe
tRNAPhe
Phenylalanine-Specific tRNA
tRNA(Phe)

A transfer RNA which is specific for carrying phenylalanine to sites on the ribosomes in preparation for protein synthesis.


English Sweating Sickness
Sudor Anglicus
Sweating Sickness

A clinical condition characterized by fever and profuse sweating and associated with high mortality. It occurred in epidemic form five times in the fifteenth and sixteenth centuries in England, first in 1485 and last in 1551, specially during the summer and early autumn, attacking the relatively affluent adult male population. The etiology was unknown.


The lateral of the two terminal branches of the sciatic nerve. The peroneal (or fibular) nerve provides motor and sensory innervation to parts of the leg and foot.


Oxamic Acid
Oxalamic Acid
Aminooxoacetic Acid
Oxamidic Acid

Amino-substituted glyoxylic acid derivative.


Outer portion of the intervertebral disc that surrounds the NUCLEUS PULPOSUS.


A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)


Arrestin-3
ARRB2 Protein
beta-Arrestin 2
Arrestin, beta 2

A beta-arrestin that functions similarly to BETA-ARRESTIN 1 in regulating signaling by G-PROTEIN-COUPLED RECEPTORS. It is expressed at high levels in the central nervous system where it may regulate signaling by SYNAPTIC RECEPTORS.


Parasitic Pregnancy Complications
Complications, Parasitic Pregnancy
Pregnancy, Parasitic Complications
Pregnancy Complications, Parasitic

The co-occurrence of pregnancy and parasitic diseases. The parasitic infection may precede or follow FERTILIZATION.


The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.


Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome

Together with the Apc2 subunit, forms the catalytic core of the E3 ubiquitin ligase, anaphase-promoting complex-cyclosome. It has a RING H2 domain which interacts with the cullin domain of Apc2. Apc11 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.


An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants.


Chronobiology Phenomenon
Chronobiology Concepts
Chronobiology Phenomena

Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.


Thiamin Pyrophosphokinase
Thiamine Pyrophosphokinase

An enzyme that catalyzes the formation of thiamine pyrophosphate from ATP and thiamine. EC 2.7.6.2.


G Protein-Coupled Receptor Kinase 1
Rhodopsin Kinase
Opsin Kinase
G-Protein-Coupled Receptor Kinase 1

A PROTEIN-SERINE-THREONINE KINASE that is found in PHOTORECEPTOR CELLS. It mediates light-dependent PHOSPHORYLATION of RHODOPSIN and plays an important role in PHOTOTRANSDUCTION.


Hermanski-Pudlak Syndrome
Hermansky-Pudlak Syndrome

Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.


The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.


Marburg Virus Disease
Marburg Disease
Marburg Hemorrhagic Fever

An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.


National Center for Advancing Translational Sciences (U.S.)

A unit of the National Institutes of Health that seeks to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. The Center was established in 2011.


Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.


Glucose-6-Phosphate Dehydrogenase
Glucosephosphate Dehydrogenase


Infections, Cardiovascular
Cardiovascular Infections

Pathological conditions of the CARDIOVASCULAR SYSTEM caused by infections.


A subtype of enteroendocrine cells found in the gastrointestinal MUCOSA, particularly in the glands of PYLORIC ANTRUM; DUODENUM; and ILEUM. These cells secrete mainly SEROTONIN and some neuropeptides. Their secretory granules stain readily with silver (argentaffin stain).


Disinfectant used in vapor form to sterilize vaccines, grafts, etc. The vapor is very irritating and the liquid form is carcinogenic.


Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.


Corynebacterium parvum
Propionibacterium acnes
Corynebacterium acnes

A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.


Poisoning, Heavy Metals, Nervous System
Heavy Metal Poisoning, Nervous System

Conditions associated with damage or dysfunction of the nervous system caused by exposure to heavy metals, which may cause a variety of central, peripheral, or autonomic nervous system injuries.


NIL-2-A Zinc Finger Protein
Transcription Factor 8
Zeb1 Transcription Factor
TCF8 Protein
Zinc Finger E-box-Binding Homeobox 1

A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.


Coiled-coil Myosin-like Bcl2-interacting Protein

An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of  phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.


Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.


Schwannomin
Moesin-Ezrin-Radixin-Like Protein
Merlin
Neurofibromin 2
NF2 Gene Product
Schwannomin Protein
Neurofibromatosis Type 2 Protein
Neurofibromatosis 2 Gene Product

A membrane protein homologous to the ERM (Ezrin-Radixin-Moesin) family of cytoskeleton-associated proteins which regulate physical properties of membranes. Alterations in neurofibromin 2 are the cause of NEUROFIBROMATOSIS 2.


Estrogen-Like Plant Extracts
Plant Estrogens
Phytoestrogens
Phytoestrogen
Plant Estrogen
Phyto-Estrogen

Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.


Penaeus
Metapenaeus
Penaeid Shrimp
Penaeidae
Shrimp, Penaeid

A family of CRUSTACEA, order DECAPODA, comprising the penaeid shrimp. Species of the genus Penaeus are the most important commercial shrimp throughout the world.


Exophthalmic Goiter
Graves' Disease
Basedow's Disease
Basedow Disease
Graves Disease
Goiter, Exophthalmic
Hyperthyroidism, Autoimmune

A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).


Dental Prosthesis Retention
Prosthesis Retention, Dental
Retention, Dental Prosthesis

Holding a DENTAL PROSTHESIS in place by its design, or by the use of additional devices or adhesives.


Supracommissural Septum
Septum Lucidum
Septum Pelusidum
Septum Pellucidum

A triangular double membrane separating the anterior horns of the LATERAL VENTRICLES of the brain. It is situated in the median plane and bounded by the CORPUS CALLOSUM and the body and columns of the FORNIX (BRAIN).


Nerve XI
Cranial Nerve XI
Spinal Accessory Nerve
Nervus Accessorius
Eleventh Cranial Nerve
Accessory Nerve

The 11th cranial nerve which originates from NEURONS in the MEDULLA and in the CERVICAL SPINAL CORD. It has a cranial root, which joins the VAGUS NERVE (10th cranial) and sends motor fibers to the muscles of the LARYNX, and a spinal root, which sends motor fibers to the TRAPEZIUS and the sternocleidomastoid muscles.


Focal Nodular Hyperplasia
Hyperplasia, Focal Nodular

Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. The pale colored central scar represents large blood vessels with hyperplastic fibromuscular layer and narrowing lumen.


Assimilatory Nitrate Reductase, NADH-Dependent

An NAD-dependent enzyme that catalyzes the oxidation of nitrite to nitrate. It is a FLAVOPROTEIN that contains IRON and MOLYBDENUM and is involved in the first step of nitrate assimilation in PLANTS; FUNGI; and BACTERIA. It was formerly classified as EC 1.6.6.1.


Phosphotransferases, ATP
Kinases
Phosphotransferases
Kinase
Transphosphorylases

A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.


Medical Education, Undergraduate
Undergraduate Medical Education
Education, Medical, Undergraduate
Education, Undergraduate Medical

The period of medical education in a medical school. In the United States it follows the baccalaureate degree and precedes the granting of the M.D.


Entamoebiasis
Entamoeba histolytica Infection
Entamoeba Infections

Infection with amoebae of the genus ENTAMOEBA. Infection with E. histolytica causes DYSENTERY, AMEBIC and LIVER ABSCESS, AMEBIC.


Regulatory Factor X Transcription Factors

A family of eukaryotic transcription factors that recognize and bind to a highly-conserved cis-regulatory sequence (X-box) within the promoter region of MHC CLASS II GENES. They contain a conserved winged-helix DNA binding domain and function as homo or heterodimers.


Proto-Oncogene Protein c-bcl-6
B-Cell Lymphoma 6 Protein
Proto-Oncogene Proteins c-bcl-6
Zinc Finger Protein 51
c-bcl-6 Proto-Oncogene Proteins
bcl-6 Proto-Oncogene Proteins
Proto-Oncogene Protein bcl-6
c-bcl-6 Protein

A DNA-binding protein that contains an N-terminal BTB (POZ) DOMAIN and C-terminal CYS2-HIS2 ZINC FINGERS. It represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES. Aberrant Blc-6 expression is associated with certain types of human B-CELL LYMPHOMA.


Graft-vs-Tumor Response
Graft vs Tumor Effect
Graft-vs-Neoplasm Effect
Graft-vs-Tumor Effect
Graft-vs-Neoplasm Response
Graft vs Neoplasm Effect

Immunological rejection of tumor tissue/cells following bone marrow transplantation.


Hydatidiform Mole
Hydatid Mole
Pregnancy, Molar
Hydatidiform Mole, Complete
Molar Pregnancy
Hydatidiform Mole, Partial

Derived from the fertilization of an apparently normal ovum by two sperm. Partial hydatidiform moles are characterized by focal chorionic villi swelling, focal trophoblastic hyperplasia, and identifiable fetal or embryonic tissue. Partial moles generally have a triploid karyotype.


Microgravity
Zero Gravity
Weightlessness

Condition in which no acceleration, whether due to gravity or any other force, can be detected by an observer within a system. It also means the absence of weight or the absence of the force of gravity acting on a body. Microgravity, gravitational force between 0 and 10 -6 g, is included here. (From NASA Thesaurus, 1988)


Tenth Cranial Nerve
Nerve X
Nervus Vagus
Pneumogastric Nerve
Vagus Nerve
Cranial Nerve X

The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).


Solute Carrier Family 25 (Mitochondrial Carrier - Adenine Nucleotide Translocator), Member 4

Adenine Nucleotide Translocator, Muscle Isoform

A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).


Allergic Angina Syndrome
Allergic Acute Coronary Syndrome
Kounis Syndrome
Allergic Myocardial Infarction

A disorder of cardiac function secondary to hypersensitivity reactions. It is characterized by coexistence of acute coronary syndromes and cardiac MAST CELL and PLATELET ACTIVATION. It may be induced by exposure to drugs (e.g., antibiotics, anesthetics, contrast media), food, and environmental triggers (e.g., insect bites and stings, poison ivy).


Operating Room Nursing
Nursing, Operating Room

The functions of the professional nurse in the operating room.


Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.


Transcultural Nursing
Nursing, Transcultural

A nursing specialty created to answer the need for developing a global perspective in the practice of nursing in a world of interdependent nations and people. The focus of this nursing discipline is on the integration of international and transcultural content into the training. Courses include study in the area of cultural differences, nursing in other countries, and international health issues and organizations, as an example.


Morphine Addiction
Morphine Abuse
Morphine Dependence

Strong dependence, both physiological and emotional, upon morphine.


Analysis, Transactional
Transactional Analysis

A psychoanalytic therapy wherein each social transaction is analyzed to determine the involved ego state (whether parent-like, child-like, or adult-like) as a basis for understanding behavior.


Genetic Technic
Genetic Technics
Technique, Genetic
Technics, Genetic
Genetic Technique
Technic, Genetic
Genetic Techniques
Techniques, Genetic

Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.


Monovinyl Protochlorophyllide
MV-PChlide
Protochlorophyllide A
Protochlorophyllide

A photo-active pigment localized in prolamellar bodies occurring within the proplastids of dark-grown bean leaves. In the process of photoconversion, the highly fluorescent protochlorophyllide is converted to chlorophyll.


A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.


An embryonic structure that helps guide proper descent of gonads into their final positions. It attaches the caudal end of the fetal GONADS to the developing SCROTUM in male and the labium majorum in female. It gives rise to the caudal ligaments of the gonad: the scrotal ligament in male and the uterine round and proper ovarian ligaments in female. It includes morphofunctional equivalent structures in non-mammals.


An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.


2,4-Dichlorophenoxyacetic Acid, Lithium Salt

2,4-Dichlorophenoxyacetic Acid, Sodium Salt

2,4-Dichlorophenoxyacetic Acid, Ammonium Salt

2,4-Dichlorophenoxyacetic Acid, Potassium Salt

An herbicide with irritant effects on the eye and the gastrointestinal system.


In certain living species, a period of dormancy during the summer months marked by decreased metabolism.


Arsenamide Caparsolate Thioarsenite Thiacetarsamide

Proposed chemotherapeutic agent against filaria and trichomonas.


An amorphous region of electron dense material in the cytoplasm from which the MICROTUBULES polymerization is nucleated. The pericentriolar region of the CENTROSOME which surrounds the CENTRIOLES is an example.


Nuclear Receptor Coactivator-1
NCoA-1 Protein
Steroid Receptor Coactivator 1
Nuclear Receptor Coactivator 1

A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a HISTONE ACETYLTRANSFRASE activity that may play a role in the transcriptional activation of CHROMATIN regions.


Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome

Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.


A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. It is the source of cedarwood oil. Cedar ordinarily refers to this but also forms part of the name of plants in other genera.


New World marsupials of the family Didelphidae. Opossums are omnivorous, largely nocturnal and arboreal MAMMALS, grow to about three feet in length, including the scaly prehensile tail, and have an abdominal pouch in which the young are carried at birth.


Traditional concepts of medicine and associated methods reflected in medicine in the ARAB WORLD.


Radiation-Induced Abnormalities
Abnormalities, Radiation-Induced

Congenital changes in the morphology of organs produced by exposure to ionizing or non-ionizing radiation.


A plant genus of the family ALISMATACEAE that grows in salty marshes and is used for phytoremediation of oil spills. The unisexual flowers have 3 sepals and 3 petals. Members contain trifoliones (DITERPENES).


A family of enzymes that catalyze the exonucleolytic cleavage of DNA. It includes members of the class EC 3.1.11 that produce 5'-phosphomonoesters as cleavage products.


Compounds based on a 7-membered heterocyclic ring including an oxygen. They can be considered a medium ring ether. A natural source is the MONTANOA plant genus. Some dibenzo-dioxepins, called depsidones, are found in GARCINIA plants.


Phytosteroids
Phytosterols
Phytosteroid
Plant Steroids
Phytosterol
Plant Steroid
Plant Sterol
Plant Sterols

A class of organic compounds known as sterols or STEROIDS derived from plants.


Canthaxanthine
Food Orange 8
Carophyll Red
Orobronze
Canthaxanthin
C.I. 40850
Roxanthin Red 10

A trans-carotenoid pigment widely distributed in nature. The compound is used as an oral suntanning agent and as a food and drug coloring agent. Oral ingestion of the compound causes canthaxanthin retinopathy.


An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.


Orofacial Granulomatosis
Granulomatosis, Orofacial

A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. Among experts there is disagreement on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease.


Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination

Emtricitabine-Tenofovir Disoproxil Fumarate Drug Combination

A pharmaceutical preparation of emtricitabine and tenofovir that is used as an ANTI-HIV AGENT in the treatment and prevention of HIV INFECTIONS.


Transdifferentiation, Cell
Cell Transdifferentiation

A naturally occurring phenomenon where terminally differentiated cells dedifferentiate to the point where they can switch CELL LINEAGES. The cells then differentiate into other cell types.


Absent Right Atrioventricular Connection

Absence of the orifice between the RIGHT ATRIUM and RIGHT VENTRICLE, with the presence of an atrial defect through which all the systemic venous return reaches the left heart. As a result, there is left ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR) because the right ventricle is absent or not functional.


Methylthiouracil Metacil 4-Methyl-2-thiouracil Alkiron Thimecil

A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism.


An oviparous burrowing mammal of the order Monotremata native to Australia, Tasmania, and New Guinea. It has hair mingled with spines on the upper part of the body and is adapted for feeding on ants.


Pentanols
Hydroxypentanes
Methylbutanols
Alcohols, Amyl
Pentyl Alcohols

Isomeric forms and derivatives of pentanol (C5H11OH).


Phosphatidyl Inositol Phosphates
Polyphosphoinositide
Polyphosphoinositides
Phosphatidylinositol Phosphates

Phosphatidylinositols in which one or more alcohol group of the inositol has been substituted with a phosphate group.


Positive Transcriptional Elongation Factor B

Positive Transcription Elongation Factor B

A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.


Tetramon
Tetraethylammonium Compounds
Tetrylammonium

Quaternary ammonium compounds that consist of an ammonium cation where the central nitrogen atom is bonded to four ethyl groups.


A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)


An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)


Petrolatum, Liquid
Liquid Paraffin
Drakeol
Vaseline Oil
Mineral Oil

A mixture of liquid hydrocarbons obtained from petroleum. It is used as laxative, lubricant, ointment base, and emollient.


The discharge of substances from the blood supply via the URINARY TRACT.


Sphingolipid Storage Diseases
Sphingolipidosis
Sphingolipidoses

A group of inherited metabolic disorders characterized by the intralysosomal accumulation of SPHINGOLIPIDS primarily in the CENTRAL NERVOUS SYSTEM and to a variable degree in the visceral organs. They are classified by the enzyme defect in the degradation pathway and the substrate accumulation (or storage). Clinical features vary in subtypes but neurodegeneration is a common sign.


Trimeperidine Dimethylmeperidine Isopromedol Promedol

A narcotic analgesic similar to MEPERIDINE; it exists in four stereoisomers, two of which, the beta (isopromedol) and the gamma (trimeperidine) are active.


Cardioplegia
Induced Heart Arrest
Induced Cardiac Arrest
Cardiac Arrest, Induced
Heart Arrest, Induced

A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).


Gaseous elements, chemicals that are in the atmosphere that may contribute to GREENHOUSE EFFECT.


Viral Activation
Virus Induction
Virus Activation
Prophage Induction
Prophage Excision

The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.


Frameworks of empirical evidence used to study and interpret social phenomena.


Middle East Respiratory Syndrome Coronavirus

Middle East respiratory syndrome-related coronavirus

A coronavirus first reported in the summer of 2012 in a pneumonia patient in SAUDI ARABIA. It is related to SARS VIRUS. MERS-CoV has an estimated incubation period of 12 days and symptoms include renal failure and severe acute pneumonia with often fatal outcome.


Ossicular Prosthesis Implantation
Ossicular Replacement
Replacement, Ossicular

Surgical insertion of an implant to replace one or more of the ear ossicles.


The presence of bacteria, viruses, and fungi in the air. This term is not restricted to pathogenic organisms.


The use of systematic methods of ethical examination, such as CASUISTRY or ETHICAL THEORY, in reasoning about moral problems.


An iron-binding cyclic trimer of 2,3-dihydroxy-N-benzoyl-L-serine. It is produced by E COLI and other enteric bacteria.


Glia-Derived Nexin 1
Protease Nexin I
Serpin E2
Protease Inhibitor 7
Serpin Peptidase Inhibitor, Clade E

A protease nexin and serpin subtype that is specific for several SERINE PROTEASES including UROKINASE; THROMBIN; TRYPSIN; and PLASMINOGEN ACTIVATORS.


Uroporphyrinogen Carboxy-Lyase
Uroporphyrinogen Decarboxylase
Uroporphyrinogen III Decarboxylase

An enzyme that catalyzes the decarboxylation of UROPORPHYRINOGEN III to coproporphyrinogen III by the conversion of four acetate groups to four methyl groups. It is the fifth enzyme in the 8-enzyme biosynthetic pathway of HEME. Several forms of cutaneous PORPHYRIAS are results of this enzyme deficiency as in PORPHYRIA CUTANEA TARDA; and HEPATOERYTHROPOIETIC PORPHYRIA.


Equinus Deformity
Talipes Equinus
Talipes Equinovalgus
Equinus Contracture


Inflammation of the OUTER EAR including the external EAR CANAL, cartilages of the auricle (EAR CARTILAGE), and the TYMPANIC MEMBRANE.


N-Nitrosodimethylamine
Nitrosodimethylamine
Dimethylnitrosamine
NDMA Nitrosodimethylamine

A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.


Behavior, Adolescent
Adolescent Behavior

Any observable response or action of an adolescent.


UDP-Glucuronic Acid 3-O-beta-D-Galactosyl-D-Galactose Glucuronosyltransferase

A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.


Bio-Resonance Therapy
Bio-Physical Information Therapy
Bioresonance Therapy
MORA Therapy

A form of holistic medicine in which ELECTROMAGNETIC WAVES are used to diagnose and treat human and animal illness via manipulation of endogenous electromagnetic oscillations corresponding to the patient's current physiological condition.


Pyrexial Convulsion
Seizure, Febrile, Simple
Convulsions, Febrile
Seizures, Febrile
Febrile Fit
Febrile Convulsion Seizure
Fever Convulsion
Fever Seizure
Pyrexial Seizure
Febrile Seizures
Seizure, Febrile, Complex

Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)


The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.


Cognitive Enhancers
Anti-Dementia Agents
Nootropic Drugs
Procognitive Agents
Nootropics
Nootropic Agents
Antidementia Agents

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms.


Helper Cells
T-Lymphocytes, Helper
Inducer Cells
T-Lymphocytes, Helper-Inducer
Helper T-Cells
Helper-Inducer T-Lymphocytes
T-Cells, Helper-Inducer
T-Lymphocytes, Inducer

Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.


ER-Negative PR-Negative HER2-Negative Breast Cancer

ER-Negative PR-Negative HER2-Negative Breast Neoplasms

Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.


B-Lymphocytes, Regulatory
Regulatory B-Cells
Breg Cells
B-Cells, Regulatory

B-cells that have a role in regulating the immune response including the production of CYTOKINES. This function is in addition to their traditional role in making antibodies.


An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.


Immune Thrombocytopenia
Autoimmune Thrombocytopenia
Idiopathic Thrombocytopenic Purpura
Thrombocytopenic Purpura, Autoimmune
Werlhof's Disease
Purpura, Thrombocytopenic, Autoimmune
Autoimmune Thrombocytopenic Purpura
Immune Thrombocytopenic Purpura
Purpura, Thrombocytopenic, Idiopathic
Werlhof Disease

Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.


Central retinal vein and its tributaries. It runs a short course within the optic nerve and then leaves and empties into the superior ophthalmic vein or cavernous sinus.


Viral Hepatitis, Human
Hepatitis, Viral, Human

INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).


15-Lipoxygenase
Arachidonic Acid 15-Lipoxygenase
Arachidonate 15-Lipoxygenase

An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.


Pyridine nucleotide transhydrogenase, AB-Specific

A NADP transhydrogenase subtype found in certain types of BACTERIA and mammalian MITOCHONDRIA. This transhydrogenase uses a mechanism that can transfer hydrogen to either side, A or B, of the NAD(+) or NADP(+) ring structure. In heart mitochondria, the enzyme is A-specific with respect to NAD(+) and B-specific with respect to NADP(+).


Chromatography, Ion Exchange
Chromatography, Ion-Exchange
Ion-Exchange Chromatography

Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.


Transfer RNA, Pro
Iso-tRNA(Pro)
RNA, Transfer, Pro
Proline-Specific tRNA
tRNA(Pro)
tRNAPro

A transfer RNA which is specific for carrying proline to sites on the ribosomes in preparation for protein synthesis.


T-Lymphocytes
Thymus-Dependent Lymphocytes
T-Cells

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.


Staphylococcus Phages
Staphylococcal Bacteriophage
Staphylococcal Phages
Staphylococcal Bacteriophages
Staphylococcus Phage


Respiratory Paralysis
Paralysis, Respiratory Muscle
Diaphragmatic Paralysis

Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHERAL NERVE DISEASES; NEUROMUSCULAR JUNCTION DISEASES; SPINAL CORD DISEASES; injury to the PHRENIC NERVE; and other disorders.


Chemically-engineered oligonucleotides used to selectively inhibit expression of target genes through sequence-specific binding of corresponding microRNA (miRNA) sites.


Cubozoa
Carybdea
Sea Wasps
Jellyfish, Box
Box Jellyfish
Chironex

Genus of box jellyfish in the family Carybdeidae.


Bone Marrow Neoplasms
Neoplasms, Bone Marrow

Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.


alpha Proteobacteria
Alphaproteobacteria
Proteobacteria alpha

A class in the phylum PROTEOBACTERIA comprised mostly of two major phenotypes: purple non-sulfur bacteria and aerobic bacteriochlorophyll-containing bacteria.


ROC Curve
ROC Analysis
Receiver Operating Characteristic
Analysis, ROC

A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.


Problem Behavior
Disruptive Behavior
Dysfunctional Behavior, Psychology
Behavioral Problem

Troublesome or disruptive behavioral displays.


A vascular malformation of developmental origin characterized pathologically by ectasia of superficial dermal capillaries, and clinically by persistent macular erythema. In the past, port wine stains have frequently been termed capillary hemangiomas, which they are not; unfortunately this confusing practice persists: HEMANGIOMA, CAPILLARY is neoplastic, a port-wine stain is non-neoplastic. Port-wine stains vary in color from fairly pale pink to deep red or purple and in size from a few millimeters to many centimeters in diameter. The face is the most frequently affected site and they are most often unilateral. (From Rook et al., Textbook of Dermatology, 5th ed, p483)


cdc25 Guanine Nucleotide Exchange Factor

ras Guanine Nucleotide Releasing Factor 1

A guanine nucleotide exchange factor that is expressed primarily in neuronal tissue and may be specific for the Ha-ras homolog of the RAS PROTEINS.


Atlanto-Occipital Joint
Atloido-Occipital Joint

The point of articulation between the OCCIPITAL BONE and the CERVICAL ATLAS.


Bemecor 4'''-O-Methyldigoxin Lanitop Medigoxin Lanirapid Metildigoxin Medixin beta-Methyldigoxin Methyldigoxin

A semisynthetic digitalis glycoside with the general properties of DIGOXIN but more rapid onset of action. Its cardiotonic action is prolonged by its demethylation to DIGOXIN in the liver. It has been used in the treatment of congestive heart failure (HEART FAILURE).


The functional hereditary units of FUNGI.


Viruses whose hosts are bacterial cells.


A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, with a single species: HERPESVIRUS 1, GALLID.


A course of study offered by an educational institution.


Leucine Enkephalin
Leu(5)-Enkephalin
Enkephalin, Leucine
Leu-Enkephalin
5-Leucine Enkephalin

One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.


Major Histocompatibility Complex Enhancer-Binding Protein MAD3

An I-kappa B protein that inhibits the activity of dimeric NF-KAPPA B P50-REL complexes, sequesters transcription factor NF-kappaB as an inactive complex in the cytoplasm; and prevents NF-kappaB nuclear translocation and DNA binding.


A venomous New World spider with an hourglass-shaped red mark on the abdomen.


Neoplasm Micrometastases
Micrometastases, Neoplasm
Neoplasm Micrometastasis
Micrometastasis
Micrometastasis, Neoplasm

Newly arising secondary tumors so small they are difficult to detect by physical examination or routine imaging techniques.


Psychology, Forensic
Forensic Psychology

A specialty in professional psychology characterized by activities primarily intended to provide professional psychological expertise within the judicial and legal systems.


Carboxylic acids that have open-chain molecular structures as opposed to ring-shaped structures.


Adenosine Diphosphatase
ATP-ADPase
ADP Phosphohydrolase
ADPase
ATP Diphosphohydrolase
Apyrase
ATP-Diphosphatase

A calcium-activated enzyme that catalyzes the hydrolysis of ATP to yield AMP and orthophosphate. It can also act on ADP and other nucleoside triphosphates and diphosphates. EC 3.6.1.5.


An enzyme that catalyzes the demethylation of L-homocysteine to L-METHIONINE.


c-jun Kinase-1
Stress-Activated Protein Kinase JNK1
Stress-Activated Protein Kinase gamma
SAP Kinase-1
Stress-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 8
c-jun N-Terminal Kinase 1
MAPK8 Mitogen-Activated Protein Kinase
JNK1 Kinase
SAPK1 Mitogen-Activated Protein Kinase

A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.


Videotapes
Tape Recording, Video
Videotape Recording

Recording of visual and sometimes sound signals on magnetic tape.


Canine respiratory coronavirus
Coronavirus, Canine
Canine Coronavirus

A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.


Bacteriophages T
Phages T
T-Phages
Coliphages T

A series of 7 virulent phages which infect E. coli. The T-even phages T2, T4; (BACTERIOPHAGE T4), and T6, and the phage T5 are called "autonomously virulent" because they cause cessation of all bacterial metabolism on infection. Phages T1, T3; (BACTERIOPHAGE T3), and T7; (BACTERIOPHAGE T7) are called "dependent virulent" because they depend on continued bacterial metabolism during the lytic cycle. The T-even phages contain 5-hydroxymethylcytosine in place of ordinary cytosine in their DNA.


Infant, Newborn, Screening
Newborn Screening
Neonatal Screening
Newborn Infant Screening

The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.


beta-N-Acetylglucosaminide beta 1-4 Galactosyltransferase

An enzyme that catalyzes the transfer of galactose from UDP-galactose to a specific glycoprotein receptor, 2-acetamido-2-deoxy-D-glucosyl-glycopeptide, during glycopeptide synthesis. EC 2.4.1.38.


Glyceraldehyde-3-Phosphate Dehydrogenase, NADP-Dependent, Phosphorylating

Glyceraldehyde-3-Phosphate Dehydrogenase, NADP, Phosphorylating

A phosphorylating glyceraldehyde-3-phosphate dehydrogenase found in the CHLOROPLASTS of higher plants. This enzyme exists as an A2B2 heterotetramer and transfers hydrogen to NADP. It plays an important role in catalyzing the reductive step of the Calvin cycle.


Calcium-Calmodulin-Dependent Protein Kinase IV

Calcium-Calmodulin-Dependent Protein Kinase Type 4

A monomeric calcium-calmodulin-dependent protein kinase subtype that is primarily expressed in neuronal tissues; T-LYMPHOCYTES and TESTIS. The activity of this enzyme is regulated by its phosphorylation by CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE.


Adenosine Cyclic Monophosphate-Dependent Protein Kinases

A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.


Analogs of RNA cap compounds which do not have a positive charge. These compounds inhibit the initiation of translation of both capped and uncapped messenger RNA.


Common form of habitual body manipulation which is an expression of tension.


Kidney Concentrating Ability
Urine Concentrating Ability

The ability of the kidney to excrete in the urine high concentrations of solutes from the blood plasma.


Peptidylarginine Deiminase I
PADI1 Protein
Peptidyl Arginine Deiminase Type I
Peptidylarginine Deiminase Type I
Peptidylarginine Deiminase Type 1
Protein Arginine Deiminase 1
Protein Arginine Deiminase Type I
Protein-Arginine Deiminase Type I
PAD Type I
Protein-Arginine Deiminase Type 1
Protein Arginine Deiminase Type 1
Peptidyl Arginine Deiminase Type 1

A peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.


Scintillation Cameras
Scinti-Cameras
Gamma Cameras
Nuclear Cameras

Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.


Sexual Abuse, Child
Child Abuse, Sexual
Molestation, Sexual, Child
Sexual Abuse of Child
Child Molestation, Sexual

Sexual maltreatment of the child or minor.


Creatine Kinase, Mitochondrial Form
Mitochondrial Creatine Kinase
Creatine Kinase, Mitochondrial

A form of creatine kinase found in the MITOCHONDRIA.


Liquid Phase Extraction
Liquid-Liquid Extraction

The removal of a soluble component from a liquid mixture by contact with a second liquid, immiscible with the carrier liquid, in which the component is preferentially soluble. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


Confounding Variables
Confounding Factors, Epidemiology
Confounding Variables, Epidemiologic
Confounding Factor, Epidemiologic
Confounding Variables, Epidemiological
Confounding Factors, Epidemiologic
Confounding Factors, Epidemiological

Factors that can cause or prevent the outcome of interest but are not intermediate variables of the factor(s) under investigation.


Noncompaction of the Left Ventricular Myocardium, Autosomal Dominant

Isolated Noncompaction of the Left Ventricular Myocardium, X-Linked

Isolated Noncompaction of the Ventricular Myocardium

Isolated Non-compaction of the Ventricular Myocardium

Mutations in the tafazzin gene are associated with X-Linked Isolated Noncompaction of the Left Ventricular Myocardium. BARTH SYNDROME is an allelic disorder.


Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

Receptor, Granulocyte-Macrophage Colony-Stimulating Factor

Receptors that bind and internalize the granulocyte-macrophage stimulating factor. Their MW is believed to be 84 kD. The most mature myelomonocytic cells, specifically human neutrophils, macrophages, and eosinophils, express the highest number of affinity receptors for this growth factor.


Hib
Haemophilus influenzae type b
Hemophilus influenzae type b

A type of H. influenzae isolated most frequently from biotype I. Prior to vaccine availability, it was a leading cause of childhood meningitis.


Excitatory Amino Acid
Amino Acids, Excitatory
Excitatory Amino Acids

Endogenous amino acids released by neurons as excitatory neurotransmitters. Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory transmitter for many years, but the extent of its role as a transmitter is unclear.


Acute Encephalitis Syndrome
Encephalopathy, Febrile
Acute Febrile Encephalopathy

Acute onset of fever accompanied by seizures, cerebral inflammation and a change in mental status (e.g., confusion, disorientation, and coma).


Depiction of medical issues or themes via the arts including visual, oral, or written forms of expression.


Ectromelia, Infectious
Mousepox
Infectious Ectromelia
Mouse Pox

A viral infection of mice, causing edema and necrosis followed by limb loss.


jun Oncogene
jun Genes
Genes, jun
c-jun Proto-Oncogenes
v-jun Genes
v-jun Oncogenes
c-jun Genes
jun Proto-Oncogene

Retrovirus-associated DNA sequences (jun) originally isolated from the avian sarcoma virus 17 (ASV 17). The proto-oncogene jun (c-jun) codes for a nuclear protein which is involved in growth-related transcriptional control. Insertion of c-jun into ASV-17 or the constitutive expression of the c-jun protein produces tumorgenicity. The human c-jun gene is located at 1p31-32 on the short arm of chromosome 1.


Intermediate Lobe of Pituitary
Pars Intermedia of Pituitary
Pituitary Gland, Intermediate
Pituitary Pars Intermedia

The intermediate lobe of the pituitary gland. It shows considerable size variation among the species, small in humans, and large in amphibians and lower vertebrates. This lobe produces mainly MELANOCYTE-STIMULATING HORMONES and other peptides from post-translational processing of pro-opiomelanocortin (POMC).


Compounds that either share the structure of fibric acid in their molecular arrangement or are considered variants of the fibric acid structure.


Athletic Injuries
Injuries, Sports
Injuries, Athletic
Sports Injuries

Injuries incurred during participation in competitive or non-competitive sports.


Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.


Amino Acid Transport System y+L
Amino Acid Transport System yPlus L
System y+L Transporter

A leucine-sensitive amino acid transport system with high affinity for basic amino acids( AMINO ACIDS, BASIC).


Inhaling
Inhalation
Inspiration, Respiratory


Brite Fat Cells
Beige Brite Cells
Adipocytes, Brite
Adipocytes, Beige
Beige Brite Adipocytes
Beige Fat Cells

Brown fat-like cells that develop in the WHITE FAT from non-MYOGENIC REGULATORY FACTOR 5 expressing CELL LINEAGE.


Chromatography, Paper
Paper Chromatography

An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).


Camurati-Engelmann Syndrome
Progressive Diaphyseal Dysplasia
Diaphyseal Hyperostosis
Diaphyseal Dysplasia 1, Progressive
Camurati-Engelmann Disease
Engelmann Disease
Diaphyseal Dysplasia, Progressive
Engelmann's Disease

An autosomal dominant form of dysplasia that is characterized by progressive thickening of diaphyseal cortex of long bones. Mutations in the gene that encodes TRANSFORMING GROWTH FACTOR BETA1 are one cause of this disorder.


A mild, eruptive skin disease of milk cows caused by COWPOX VIRUS, with lesions occurring principally on the udder and teats. Human infection may occur while milking an infected animal.


Dicoumarin Bishydroxycoumarin Dicumarol Dicoumarol

An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.


A family of DNA plant viruses that infect eukaryotic algae.


Organizational Case Studies
Management Case Studies
Case Studies, Organizational

Descriptions and evaluations of specific health care organizations.


A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.


Amino Acids, Acidic
Acidic Amino Acids
Amino Acid, Acidic

Amino acids with side chains that are negatively charged at physiological pH.


Process in which a patient is induced into a trance-like state in order to relieve anxiety during a dental procedure.


CA 125 Antigen
Mucin-16
CA-125 Antigen
Antigen CA-125

A carbohydrate antigen that occurs in tumors of the ovary as well as in breast, kidney, and gastrointestinal tract tumors and normal tissue. While it is tumor-associated, it is not tumor-specific and may have a protective function against particles and infectious agents at mucosal surfaces.


Schizophrenia, Catatonic
Catatonic Schizophrenia

A type of schizophrenia characterized by abnormality of motor behavior which may involve particular forms of stupor, rigidity, excitement or inappropriate posture.


Soft Palate
Velum Palatinum
Palate, Soft

A movable fold suspended from the posterior border of the hard palate. The uvula hangs from the middle of the lower border.


Galactose Dehydrogenases
Galactose Oxidoreductases

D-Galactose:NAD(P)+ 1-oxidoreductases. Catalyzes the oxidation of D-galactose in the presence of NAD+ or NADP+ to D-galactono-gamma-lactone and NADH or NADPH. Includes EC 1.1.1.48 and EC 1.1.1.120.


Two off-spring from the same PREGNANCY. They are from a single fertilized OVUM that split into two EMBRYOS. Such twins are usually genetically identical and of the same sex.


Dipetalonema Infections
Dipetalonemiasis
Infections, Dipetalonema

Infections with nematodes of the genus DIPETALONEMA.


Below normal weather temperatures that may lead to serious health problems. Extreme cold is a dangerous situation that can bring on health emergencies in susceptible people.


Epidemic Parotitis Virus
Mumps virus
Myxovirus parotitidis

The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.


Fatty Acid-Transport Protein
Fatty Acid Transport Proteins

A broad category of membrane transport proteins that specifically transport FREE FATTY ACIDS across cellular membranes. They play an important role in LIPID METABOLISM in CELLS that utilize free fatty acids as an energy source.


A disorder characterized by grinding and clenching of the teeth.


Diverticulum, Meckel
Meckel Diverticulum
Meckel's Diverticulum

A congenital abnormality characterized by the outpouching or sac formation in the ILEUM. It is a remnant of the embryonic YOLK SAC in which the VITELLINE DUCT failed to close.


Healthy Eating Index
Prudent Diet
Healthy Eating
Healthy Diet
Healthy Nutrition
Diet, Healthy

Dietary patterns which have been found to be important in reducing disease risk.


Secondary Amino Acids
Imino Acids
Acids, Secondary Amino
Amino Acids, Secondary

Carboxylic acids that contain an imino group (C=NH).


Sesquiterpene Derivatives
Farnesenes
Sesquiterpenes
Farnesanes
Sesquiterpenoids

Fifteen-carbon compounds formed from three isoprenoid units with general formula C15H24.


Posterior Inferior Cerebellar Artery Syndrome

INFARCTION of the dorsolateral aspect of MEDULLA OBLONGATA in the BRAIN STEM. It is caused by occlusion of the VERTEBRAL ARTERY and/or the posterior inferior cerebellar artery. Clinical manifestations vary with the size of infarction, but may include loss of pain and temperature sensation in the ipsilateral face and contralateral body below the chin; ipsilateral HORNER SYNDROME; ipsilateral ATAXIA; DYSARTHRIA; VERTIGO; nausea, hiccup; dysphagia; and VOCAL CORD PARALYSIS. (From Adams et al., Principles of Neurology, 6th ed, p801)


Perilipins
Perilipin-Adipophilin-TIP47 Proteins
PAT Proteins
Perilipin Proteins
PLIN Proteins

A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.


An aspartate aminotransferase found in MITOCHONDRIA.


Heat Adaptation
Thermotolerance
Heat Tolerance

The ability of an organism to reduce susceptibility to heat shock, and adapt to HOT TEMPERATURE.


A spasm of the diaphragm that causes a sudden inhalation followed by rapid closure of the glottis which produces a sound.


The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed)


A plant genus of the family APIACEAE. Members contain SAPONINS.


Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.


Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.


Leukocyte L1 Protein Light Chain
Cystic Fibrosis Antigen
MRP-8 Protein
Macrophage-Related Protein-8
60B8-B Antigen
CABP-P8
Myeloid Calcium-Binding Protein P8
Calgranulin A
MRP8 Protein
S100A8 Protein
S100 A8 Protein

A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.


Central Nervous System Helminthiasis
Cerebral Helminthiasis
Helminthiasis, Central Nervous System
CNS Helminthiasis

Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).


Indigenous Health Services
Health Services, Indigenous
Indigenous Services, Health
Services, Indigenous Health

Health care provided to specific cultural or tribal peoples which incorporates local customs, beliefs, and taboos.


Fo-Ti
Polygonum multiflorum
Fallopia multiflora

A species of Fallopia in the buckwheat family (Polygonaceae). Its roots are used in TRADITIONAL CHINESE MEDICINE.


Extracellular Signal-Regulated MAP Kinases

MAP Kinases, Extracellular Signal-Regulated

A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.


The systematic checking of the condition and function of a patient's CENTRAL NERVOUS SYSTEM during the course of a surgical operation.


A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process.


Truncated Hemoglobins
Truncated Hemoglobin
TrHb Hemoglobins
Hemoglobins, Truncated

A family of hemoglobin-like proteins found in BACTERIA; PLANTS; and unicellular eukaryotes. Truncated hemoglobins are distantly related to vertebrate hemoglobins and are typically shorter than vertebrate hemoglobins by 20-40 residues.


A rare congenital abnormality resulting in the URETER passing dorsal to and being obstructed by the INFERIOR VENA CAVA.


An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.


Grandparents Grandmother Grandfather Grandparent

Member of a family who has children and grandchildren.


Proteins found in the tail sections of DNA and RNA viruses. It is believed that these proteins play a role in directing chain folding and assembly of polypeptide chains.


Two identical genes showing the same phenotypic action but localized in different regions of a chromosome or on different chromosomes. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)


Dilatation, Pathological
Dilatation, Pathologic
Pathologic Dilatations
Ectasia
Dilatations, Pathological
Pathologic Dilatation
Dilatations, Pathologic

The condition of an anatomical structure's being dilated beyond normal dimensions.


Interventional Radiology
Radiology, Interventional

Subspecialty of radiology that combines organ system radiography, catheter techniques and sectional imaging.


IBDV
Bursal Agent, Infectious
Gumboro Disease Virus
Infectious Bursal Agent
Infectious bursal disease virus
Avian Nephrosis Virus
Bursal Disease Virus, Infectious

A species of AVIBIRNAVIRUS causing severe inflammation of the bursa of Fabricius in chickens and other fowl. Transmission is thought to be through contaminated feed or water. Vaccines have been used with varying degrees of success.


A chronic infection of the CONJUNCTIVA and CORNEA caused by CHLAMYDIA TRACHOMATIS.


Oxidoreductases Acting on other Nitrogenous Compounds as Donors

Enzymes which reduce nitro groups (NITRO COMPOUNDS) and other nitrogenous compounds.


A plant genus of the family RANUNCULACEAE. Members contain isoquinoline alkaloids and triterpene glycosides.


Monkey, Bonnet
Bonnet Monkey
Macaca radiata
Bonnet Macaques

A species of macaque monkey that mainly inhabits the forest of southern India. They are also called bonnet macaques or bonnet monkeys.


PLIN5 Protein
Perilipin 5 Protein
Lipid Storage Droplet Protein 5
LSDP5 Protein
Perilipin-5
OXPAT Protein

A perilipin that functions in LIPOGENESIS; LIPOLYSIS; and fatty acid oxidation in BROWN ADIPOSE TISSUE; heart, liver, and skeletal muscle. It recruits MITOCHONDRIA to the surface of LIPID DROPLETS where it functions in both the storage of fatty acids as TRIGLYCERIDES, and their release for mitochondrial fatty acid oxidation in response to metabolic needs.


Bronze Schilder Disease
X-Linked Adrenoleukodystrophy
Schilder-Addison Complex
Adrenomyeloneuropathy
Melanodermic Leukodystrophy
Siemerling-Creutzfeldt Disease
ALD (Adrenoleukodystrophy)
Adrenoleukodystrophy
X-ALD
Addison Disease and Cerebral Sclerosis
X-ALD (X-Linked Adrenoleukodystrophy)

An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).


Bradykinin Receptors
Bradykinin Receptor
Receptors, Bradykinin

Cell surface receptors that bind BRADYKININ and related KININS with high affinity and trigger intracellular changes which influence the behavior of cells. The identified receptor types (B-1 and B-2, or BK-1 and BK-2) recognize endogenous KALLIDIN; t-kinins; and certain bradykinin fragments as well as bradykinin itself.


Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy.


Nucleoside Triphosphate Phosphohydrolase II

An enzyme which catalyzes the hydrolysis of nucleoside triphosphates to nucleoside diphosphates. It may also catalyze the hydrolysis of nucleotide triphosphates, diphosphates, thiamine diphosphates and FAD. The nucleoside triphosphate phosphohydrolases I and II are subtypes of the enzyme which are found mostly in viruses.


Web-based Intervention
Internet Intervention
Online Intervention
Internet-Based Intervention

Use of the INTERNET to facilitate the dissemination of health-related information and to connect patients to support.


Parkinson Disease, Idiopathic
Primary Parkinsonism
Lewy Body Parkinson's Disease
Parkinson's Disease
Parkinson's Disease, Lewy Body
Idiopathic Parkinson's Disease
Parkinson Disease
Lewy Body Parkinson Disease
Parkinson's Disease, Idiopathic
Paralysis Agitans
Idiopathic Parkinson Disease

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)


Receptor, Cannabinoid, CB2
CB2 Receptor
Cannabinoid Receptor CB2

A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.


Assistive Technology
Assistive Devices
Self-Help Devices

Devices, not affixed to the body, designed to help persons having musculoskeletal or neuromuscular disabilities to perform activities involving movement.


Sexual attraction or relationship between females.


Polycyclic ethers produced by Gambierdiscus (DINOFLAGELLATES) from gambiertoxins, which are ingested by fish which in turn may be ingested by humans who are susceptible to the CIGUATERA POISONING.


The portion of a cell that contains the NUCLEUS and CYTOPLASM but not CELL SURFACE EXTENSIONS such as FLAGELLA and NEURITES.


A plant genus of the family FABACEAE that contains julibroside (triterpenoid saponins).


Package Inserts
Product Labelling
Labeling, Product
Product Labeling

Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.


Enterohepatic Circulation
Circulation, Enterohepatic
Entero-Hepatic Circulation

Recycling through liver by excretion in bile, reabsorption from intestines (INTESTINAL REABSORPTION) into portal circulation, passage back into liver, and re-excretion in bile.


Sports Nutrition Sciences
Exercise Nutritional Sciences
Sports Nutritional Sciences

The study of NUTRITION PROCESSES during EXERCISE and ATHLETIC PERFORMANCE as well as specific NUTRITIONAL REQUIREMENTS of ATHLETES and the relationship between NUTRITIONAL STATUS and NUTRITION DISORDERS in athletes.


CDP Diglyceride Serine O-Phosphatidyltransferase

An enzyme that catalyzes the formation of phosphatidylserine and CMP from CDPdiglyceride plus serine. EC 2.7.8.8.


Remicade
Renflexis
Infliximab-dyyb
Inflectra
Infliximab-abda
Infliximab
Monoclonal Antibody cA2
MAb cA2

A chimeric monoclonal antibody to TNF-ALPHA that is used in the treatment of RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; PSORIATIC ARTHRITIS and CROHN'S DISEASE.


Aloxiprimum
Endosprin
2-(Acetyloxy)benzoic Acid
Magnecyl
Acylpyrin
Ecotrin
Acetysal
Easprin
Zorprin
Solupsan
Polopirin
Micristin
Dispril
Aspirin
Polopiryna
Colfarit
Acetylsalicylic Acid
Solprin

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)


A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.


The relative amount by which the average fitness of a POPULATION is lowered, due to the presence of GENES that decrease survival, compared to the GENOTYPE with maximum or optimal fitness. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)


RANTES Protein, T-Cell
RANTES
Chemokine CCL5
CCL5 Chemokine

A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.


The generic term for salts derived from silica or the silicic acids. They contain silicon, oxygen, and one or more metals, and may contain hydrogen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th Ed)


A non-neoplastic cyst of the MEIBOMIAN GLANDS of the eyelid.


Melanoma Cell Adhesion Molecule
Antigens, CD146
CD146 Antigens
S-Endo 1 Endothelial-Associated Antigen
Gicerin
CD146 Antigen
Glycoprotein MUC18

A cell adhesion molecule of the immunoglobulin superfamily that is expressed by ENDOTHELIAL CELLS where it functions to stabilize INTERCELLULAR JUNCTIONS. It is also highly expressed by melanoma tumor cells and may facilitate their METASTASIS.


Trioses
Three Carbon Sugars
Three Carbon Monosaccharides

Monosaccharide molecules that contain a three carbon backbone.


Secondary Immunization
Immunization, Secondary
Revaccination
Immunization, Booster

Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.


Administration, Intravenous
Intravenous Administration

Delivery of substances through VENIPUNCTURE into the VEINS.


Use for general articles concerning nursing education.


Premenstrual Dysphoric Disorder
Premenstrual Dysphoric Syndrome

A condition in which a woman suffers from severe depression, irritability, and tension before MENSTRUATION. Premenstrual dysphoric disorder (PMDD) may involve a wide range of physical or emotional symptoms, which are more severe and debilitating than those seen with premenstrual syndrome (PMS), and which include at least one mood-related symptom. Symptoms usually stop when, or shortly after, menstruation begins.


Traffic Pollution
Vehicle Pollution
Traffic-Related Pollution

Contamination of the ENVIRONMENT by VEHICLE EMISSIONS.


Glycogen stored in the liver. (Dorland, 28th ed)


MYND Domain
MYND Motif
MYND Domains
Zinc Finger MYND-Type

Zinc finger domains (named for myeloid, Nervy and DEAF-1) that occur in a variety of eukaryotic proteins, including RUNT-RELATED TRANSCRIPTION FACTOR 1 . They are characterized by a cluster of cysteine and histidine residues with conserved spacing that forms the zinc-binding motif and have beta-beta-alpha (see BETA-SHEET and ALPHA-HELIX) topology, similar to LIM domains (see LIM DOMAIN PROTEINS) and RING FINGER DOMAINS. MYND domains function as protein interaction motifs and have affinity for PROLINE-RICH PROTEIN DOMAINS.


Blood Plateletpheresis
Plateletpheresis
Thrombocytopheresis
Thrombocytapheresis

The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.


The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.


A plant genus of the family Plantaginaceae. Members contain DEFICIENS PROTEIN.


Bone Substitute
Replacement Material, Bone
Bone Replacement Material
Substitutes, Bone
Replacement Materials, Bone
Bone Substitutes
Bone Replacement Materials

Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.


Lymphocytic Leukemia, Acute, B and T Cell

B- and T-Cell Acute Lymphoblastic Leukemia

Leukemia, Lymphocytic, Acute, Mixed Cell

B and T Cell Acute Lymphoblastic Leukemia

Lymphocytic Leukemia, Acute, B- and T-Cell

Leukemia, Lymphocytic, Acute, Mixed-Cell

An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS.


Infections, Lentivirus
Lentivirus Infections

Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.


Pentamethylenediamine
BioDex 1
1,5-Pentanediamine
Cadaverine

A foul-smelling diamine formed by bacterial decarboxylation of lysine.


Influenza Viruses Type C
Influenza C Virus
Orthomyxoviruses Type C
Influenzavirus C

A genus of the family ORTHOMYXOVIRIDAE comprising viruses similar to types A and B but less common, more stable, more homogeneous, and lacking the neuraminidase protein. They have not been associated with epidemics but may cause mild influenza. Influenza C virus is the type species.


Developmentally Regulated EPH-Related Tyrosine Kinase

An eph family receptor found widely expressed in embryonic and adult tissues. High levels of EphB2 receptor are observed in growing AXONS and NERVE FIBERS. Several isoforms of the protein exist due to multiple alternative mRNA splicing.


Inhibitors, Adrenergic Uptake
Adrenergic Uptake Inhibitors
Adrenergic Reuptake Inhibitors
Uptake Inhibitors, Adrenergic
Reuptake Inhibitors, Adrenergic
Inhibitors, Adrenergic Reuptake

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.


Therapy, Megavitamin
Orthomolecular Therapy
Therapy, Orthomolecular
Megavitamin Therapy

The use of very large doses of vitamins or other naturally occurring substances normally present in the body, frequently for the treatment of mental disorders.


A plant genus of the family CONVOLVULACEAE. The common name of morning glory also refers to IPOMOEA. The common name of bindweed also refers to IPOMOEA; CALYSTEGIA; or POLYGONUM.


A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)


Chylomicron Remnants
Chylomicron Remnant

Metabolic products of chylomicron particles in which TRIGLYCERIDES have been selectively removed by the LIPOPROTEIN LIPASE. These remnants carry dietary lipids in the blood and are cholesterol-rich. Their interactions with MACROPHAGES; ENDOTHELIAL CELLS; and SMOOTH MUSCLE CELLS in the artery wall can lead to ATHEROSCLEROSIS.


A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.


Methodology Research, Nursing
Research, Nursing Methodology
Nursing Methodology Research
Nursing Methodological Issues Research
Clinical Methodology Research, Nursing

Research carried out by nurses concerning techniques and methods to implement projects and to document information, including methods of interviewing patients, collecting data, and forming inferences. The concept includes exploration of methodological issues such as human subjectivity and human experience.


Creating an INTERNET-based personal journal which may consist of reflections, comments, and often hyperlinks.


The complete genetic complement contained in a DNA or RNA molecule in a virus.


Stomatitis, Gangrenous
Noma
Cancrum Oris

A severe gangrenous process occurring predominantly in debilitated and malnourished children, especially in underdeveloped countries. It typically begins as a small vesicle or ulcer on the gingiva that rapidly becomes necrotic and spreads to produce extensive destruction of the buccal and labial mucosa and tissues of the face, which may result in severe disfigurement and even death. Various bacteria have been implicated in the etiology. (Dorland, 27th ed)


Matrilysin
Matrix Metalloproteinase 7
MMP7 Metalloproteinase
MMP-7 Metalloproteinase
Matrix Metalloproteinase-7

The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression.


Transferrin-Binding Protein 2
Tbp2 Transferrin-Binding Protein
Transferrin-Binding Protein B
TbpB Transferrin-Binding Protein

A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.


Doppler Ultrasonography
Doppler Ultrasound
Ultrasonography, Doppler
Doppler Ultrasound Imaging

Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)


Bloodsucking flies of the genus Glossina, found primarily in equatorial Africa. Several species are intermediate hosts of trypanosomes.


K+ Channels, Ca2+-Activated
K+ Channels, Calcium-Activated
Potassium Channels, Calcium-Dependent
Ca2+-Activated K+ Channels
Potassium Channels, Calcium-Activated
Calcium-Dependent Potassium Channels
Calcium-Activated Potassium Channel
Potassium Channel, Calcium-Activated
Calcium-Activated Potassium Channels

Potassium channels whose activation is dependent on intracellular calcium concentrations.


Unexplained symptoms reported by veterans of the Persian Gulf War with Iraq in 1991. The symptoms reported include fatigue, skin rash, muscle and joint pain, headaches, loss of memory, shortness of breath, gastrointestinal and respiratory symptoms, and extreme sensitivity to commonly occurring chemicals. (Nature 1994 May 5;369(6475):8)


Delta-6 Fatty Acid Desaturase
Linoleoyl Coenzyme A Desaturase
Linoleic Acid Delta-6 Desaturase
Delta-6-Desaturase
Linoleoyl-CoA Desaturase
Delta(6)-Desaturase
Fatty Acid Delta-6-Desaturase
Delta-6-FADTase
Linoleoyl CoA Desaturase

An enzyme that catalyzes the syn-dehydrogenation of linoleol-CoA gamma-linolenoyl-CoA. It was formerly characterized as EC 1.14.99.25.


An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.


Fiber, Dietary
Wheat Bran
Roughage
Dietary Fiber

The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.


Hospital Services, Centralized
Centralized Services, Hospital
Centralized Hospital Services
Services, Centralized Hospital

The coordination of services in one area of a facility to improve efficiency.


Choline Alphoscerate
Choline Glycerophosphate
L-alpha-Glycerylphosphorylcholine
Glycerophosphorylcholine
Glycerol 3-Phosphocholine
Choline Alfoscerate
Glycerylphosphorylcholine

A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (From Stedman, 26th ed)


A plant genus of the family RANUNCULACEAE. Members contain ACONITINE and other diterpenoid alkaloids.


Chemical Stimulation
Stimulation, Chemical

The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.


A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.


delta Proteobacteria
Deltaproteobacteria
Proteobacteria delta

A group of PROTEOBACTERIA represented by morphologically diverse, anaerobic sulfidogens. Some members of this group are considered bacterial predators, having bacteriolytic properties.


Jak1 Kinase
JAK1 Protein Tyrosine Kinase
JAK-1 Protein Tyrosine Kinase
Janus Kinase 1

A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS.


Internal Ribosome Entry Site
Internal Ribosome Entry Sites

Sequences within MESSENGER RNA that enable PROTEIN TRANSLATION INITIATION independent of 5' CAPPED RNA.


A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.


Outcome Measures
Outcomes Research
Outcomes Assessment
Outcome Assessment, Health Care
Outcome Studies
Outcome Assessment (Health Care)
Assessment, Outcomes

Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).


Protein-Serine-Threonine Kinases
Serine-Threonine Protein Kinases
Threonine Kinase
Serine-Threonine Kinase
Serine-Threonine Kinases
Protein-Threonine Kinase
Protein-Serine Kinase
Serine Kinase
Protein-Serine-Threonine Kinase

A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.


rev Genes
Genes, rev
art-trs Genes
trs-art Genes

DNA sequences that form the coding region for a protein that regulates the expression of the viral structural and regulatory proteins in human immunodeficiency virus (HIV). rev is short for regulator of virion.


Deep Circumflex Iliac Artery
Iliac Artery

Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.


Respiratory Muscle Training
Breathing Exercises

Therapeutic exercises aimed to deepen inspiration or expiration or even to alter the rate and rhythm of respiration.


Complement C3c Fragment
C3c Complement
Complement 3c
Complement Component 3c
Complement C3c

A 206-amino-acid fragment in the alpha chain (672-1663) of C3b. It is generated when C3b is inactivated (iC3b) and its alpha chain is cleaved by COMPLEMENT FACTOR I into C3c (749-954), and C3dg (955-1303) in the presence COMPLEMENT FACTOR H.


Coenzyme A Synthetases
Acyl CoA Synthetases
Coenzyme A Ligases
Acid-Thiol Ligases
Acyl Coenzyme A Synthetases
Co A Ligases

Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1.


Acute-On-Chronic Liver Failure
Liver Failure, Acute-On-Chronic
Acute-On-Chronic Liver Failure (ACLF)

Sudden liver failure in the presence of underlying compensated chronic LIVER DISEASE (e.g., LIVER CIRRHOSIS; HEPATITIS; and liver injury and failure) due to a precipitating acute hepatic insult.


T-Lymphoma Invasion and Metastasis-inducing Protein 1

A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.


Deficiency, Oxygen
Anoxemia
Oxygen Deficiency
Hypoxemia
Anoxia
Hypoxia

Relatively complete absence of oxygen in one or more tissues.


Manpower
Womanpower
Workforce
Labor Supply
Human Resources
Staffing

The number of people working or available for work or service.


Monosialosyl Tetraglycosyl Ceramide
GM1a Monosialoganglioside
G(M1) Ganglioside
GM1 Ganglioside

A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.


Osteoarthritis of the Knee
Osteoarthritis of Knee
Osteoarthritis, Knee

Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)


Housekeeping, Hospital
Hospital Housekeeping

Hospital department which manages and provides the required housekeeping functions in all areas of the hospital.


Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography

Tomography using single-photon emitting RADIONUCLIDES to create images that are captured in times corresponding to various points in the cardiac cycle.


Transmitter receptors on or near presynaptic terminals (or varicosities) which are sensitive to the transmitter(s) released by the terminal itself. Receptors for the hormones released by hormone-releasing cells are also included.


Technetium Tc 99m Hexamethylpropyleneamine Oxime

Technetium Tc 99m Hexamethylpropylene-amine Oxime

A gamma-emitting RADIONUCLIDE IMAGING agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and MYOCARDIAL PERFUSION IMAGING. It has also been used to label leukocytes in the investigation of INFLAMMATORY BOWEL DISEASES.


Atractyloside
Atractylic Acid
Atractylate

A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.


Embryonic Germ Cells
EG Cells
Germ Cells, Embryonic

PLURIPOTENT STEM CELLS that are derived from early GERM CELLS.


Urocarb
Bethanecol
Myocholine
Bethanechol Chloride
Myotonine
Bethanechol
Myotonachol
PMS-Bethanechol Chloride
Duvoid
Myo Hermes
Urecholine

A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.


Plant Root Nodulation
Nodulation, Plant Root

The formation of a nitrogen-fixing cell mass on PLANT ROOTS following symbiotic infection by nitrogen-fixing bacteria such as RHIZOBIUM or FRANKIA.


Bone Morphogenetic Protein 2B
Bone Morphogenetic Protein 4

A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.


E-Box Elements
E-Box Motifs
E-Box Sites
E-Box Sequences

DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.


Nucleoside Diphosphate Kinase, Mitochondrial

A nucleoside diphosphate kinase subtype that is localized to the intermembrane space of MITOCHONDRIA. It is believed to play a role in the synthesis of triphosphonucleotides using ATP formed through OXIDATIVE PHOSPHORYLATION.


A class of terpenes (the general formula C30H48) formed by the condensation of six isoprene units, equivalent to three terpene units.


An enzyme that catalyzes the conversion of UDP-galactose and N-acylsphingosine to D-galactosylceramide and UDP.


Merycism
Rumination Disorders
Rumination Syndrome

A gastrointestinal disorder characterized by repetitive and effortless regurgitation of ingested food from the stomach to the oral cavity in the early POSTPRANDIAL PERIOD. It is associated with functional gastrointestinal pathology (e.g., increased intra-gastric pressure) and psychiatric disorders (e.g., anxiety, depression). It is not limited to infants and distinct from GERD and VOMITING.