Dermal Scales
Epidermal Scales
Animal Scales
Cuticular Scales

Tough, horny, brittle, smooth, striated or plate-like extensions of the stratum corneum or outer layer of the skin. It serves as a protective layer in fishes, reptiles, birds, and mammals.


A dental specialty concerned with the restoration and maintenance of oral function by the replacement of missing TEETH and related structures by artificial devices or DENTAL PROSTHESES.


An infraorder (or suborder) of small PRIMATES comprised of a single family and genus.


A sampling methodology using small sample sizes when conducting surveys in small geographical or population-based areas or lots.


Pediatric Hospitals
Hospitals, Pediatric

Special hospitals which provide care for ill children.


Evaluation, planning, and use of a range of procedures and airway devices for the maintenance or restoration of a patient's ventilation.


Methylmalonyl-CoA Isomerase
Methylmalonyl-CoA Mutase

An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2.


Biological Variation, Within-Individual
Within-Person Variation
Biological Variation, Individual
Within-Individual Biological Variation
Intra-Individual Biological Variation
Within-Subject Variation

Differences in measurable biological values, characteristics, or traits, within one individual under different conditions for the individual such as fasting, season of the year, age, or state of wellness.


A specific streptogramin group B antibiotic produced by Streptomyces graminofaciens and other bacteria.


Oxosuccinates
Ketosuccinates
Oxaloacetates
Oxaloacetic Acids

Derivatives of OXALOACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include a 2-keto-1,4-carboxy aliphatic structure.


Wasp Venom
Vespid Venom
Vespid Venoms
Vespa Venoms
Wasp Venoms

Venoms produced by the wasp (Vespid) family of stinging insects, including hornets; the venoms contain enzymes, biogenic amines, histamine releasing factors, kinins, toxic polypeptides, etc., and are similar to bee venoms.


Multiple Abnormalities
Abnormalities, Multiple

Congenital abnormalities that affect more than one organ or body structure.


Angiogenesis Modulators
Angiogenesis Modulating Agents

Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents.


Photosensitive proteins expressed in the ROD PHOTORECEPTOR CELLS. They are the protein components of rod photoreceptor pigments such as RHODOPSIN.


Cathode Ray Tube
Cathode Ray Tube Display
Cathode Ray Tubes
Cathode Rays

A stream of low-energy ELECTRONS produced in cathode ray tubes.


A region in the pontine tegmentum containing nuclei and fibers associated with AUDITORY PATHWAYS.


MEDICARE Prescription Drug Improvement and Modernization Act of 2003

Assistance in managing and monitoring drug therapy for patients receiving treatment for cancer or chronic conditions such as asthma and diabetes, consulting with patients and their families on the proper use of medication; conducting wellness and disease prevention programs to improve public health; overseeing medication use in a variety of settings.


Haptophyta Prymnesium Emiliania Haptophytes Coccolithophorids Phaeocystis Haptophyceae Prymnesiophyceae Pavlova Pleurochrysis Isochrysis Prymnesiophytes

A group (or phylum) of unicellular EUKARYOTA (or algae) possessing CHLOROPLASTS and FLAGELLA.


Benzoate 4-Hydroxylase
Benzoate-Para-Hydroxylase
Benzoate 4-Monooxygenase

An enzyme that catalyzes the oxidation of BENZOATE to 4-hydroxybenzoate. It requires IRON and tetrahydropteridine.


Membrane-Type 4 Matrix Metalloproteinase

Membrane-Type Matrix Metalloproteinase 4

A membrane-type metalloproteinase that is associated with the CELL MEMBRANE via a GLYCOSYL-PHOSPHATIDYLINOSITOL linkage. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN.


Chlorpropamide Glucamide Diabinese Clorpropamid Meldian Apo-Chlorpropamide Insogen

A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)


Hypofractionated Dose, Radiation
Radiotherapy Minibeams
Radiation Dose Hypofractionation
Radiotherapy Dose Hypofractionation

A treatment schedule in which the total dose of radiation is divided into large doses but fewer exposure times.


PGE2alpha
Prostaglandin E2
Dinoprostone
PGE2 alpha
Prepidil Gel
PGE2
Prostaglandin E2alpha
Prostenon
Prostaglandin E2 alpha

The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.


Physical Therapy Specialty
Physiotherapy Specialty

The auxiliary health profession by which PHYSICAL THERAPISTS make use of PHYSICAL THERAPY MODALITIES to prevent, correct, and alleviate movement dysfunction of anatomic or physiological origin.


A group of AMOEBOZOA comprising two distinct groups with the ability to form fruiting bodies: DICTYOSTELIIDA (dictyostelid cellular slime molds) and MYXOMYCETES (plasmodial slime molds).


Tactical warfare using incendiary mixtures, smokes, or irritant, burning, or asphyxiating gases.


A species of PARVOVIRUS causing reproductive failure in pigs.


Process of evaluating the health of a patient and determining if they are healthy enough for surgery.


Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome

The largest subunit of the anaphase-promoting complex. It acts primarily as a scaffold for the proper organization and arrangement of subunits. The C-terminal region of Apc1 contains a series of tandem amino acid repeats that are also seen in the 26S proteasome regulatory particle, and may assist with forming and stabilizing protein-protein interactions.


Interleukin-21 Receptor alpha Chain
IL-21 Receptor alpha Chain
Interleukin-21 Receptor alpha Subunit

An interleukin-21 receptor subunit that combines with the INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT to form a high affinity receptor for interleukin-21. It signals via interaction of its cytoplasmic domain with JANUS KINASES such as JANUS KINASE 1 and JANUS KINASE 3.


Triatrial Heart
Subdivided Left Atrium
Cor Triatriatum Sinistrum
Cor Triatriatum

A malformation of the heart in which the embryonic common PULMONARY VEIN was not incorporated into the LEFT ATRIUM leaving behind a perforated fibromuscular membrane bisecting the left atrium, a three-atrium heart. The opening between the two left atrium sections determines the degree of obstruction to pulmonary venous return, pulmonary venous and pulmonary arterial hypertension.


Claversal
Ascolitin
meta-Aminosalicylic Acid
Lixacol
m-Aminosalicylic Acid
Mesalamine Monosodium Salt
Asacolon
Pentasa
Asacol
5-Aminosalicylate
5-Aminosalicylic Acid
Fivasa
Novo-5 ASA
Rowasa
Mesasal
Salofalk
Canasa
Mesalamine Hydrochloride
Mesalazine
Mesalamine

An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)


Metal Metabolism, Inborn Errors
Metal Metabolism, Inborn Error

Dysfunctions in the metabolism of metals resulting from inborn genetic mutations that are inherited or acquired in utero.


A plant species of the family VISCACEAE, order Santalales, subclass Rosidae. This is the traditional mistletoe of literature and Christmas. Members contain viscotoxin (5 kDa basic polypeptides related to thionins), beta-galactoside- and N-acetyl-D-galactosamine-specific lectin II (60 kDa), and polysaccharides. Mistletoe lectin I is a type 2 ribosome-inactivating protein. Commercial extracts include Plenosol, Eurixor, Helixor Isorel, Iscador, and NSC 635089 (ANTINEOPLASTIC AGENTS, PHYTOGENIC).


Cellulose
Heweten
alpha-Cellulose
Rayophane
Sulfite Cellulose
Polyanhydroglucuronic Acid
Alphacel
Avicel

A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.


Iron Proteins, Non-Heme
Nonheme Iron Proteins
Non-Heme Iron Proteins

Proteins, usually acting in oxidation-reduction reactions, containing iron but no porphyrin groups. (Lehninger, Principles of Biochemistry, 1993, pG-10)


Otology Laryngology Otolaryngology Otorhinolaryngology

A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.


Double-Masked Method
Double-Masked Study
Double-Blind Method
Double-Blind Study

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.


TPR Domain
Tetratricopeptide Repeat Domain
Tetratricopeptide Repeat
TPR Motif
Tetratricopeptide Motif

A structural motif present in a variety of proteins that mediates protein-protein interactions and assembly of multiprotein complexes. It consists of 3 to 16 tandem repeats of 34 amino acids, mostly of small and large hydrophobic residues, that form ALPHA-HELIX pairs.


Sperm Injections, Intracytoplasmic
ICSI
Injections, Sperm, Intracytoplasmic
Intracytoplasmic Sperm Injections

An assisted fertilization technique consisting of the microinjection of a single viable sperm into an extracted ovum. It is used principally to overcome low sperm count, low sperm motility, inability of sperm to penetrate the egg, or other conditions related to male infertility (INFERTILITY, MALE).


CD40 Receptor-Associated Factor 1
CD40bp Protein
LAP-1 Protein
CRAF1 Protein
TNF Receptor-Associated Factor 3
TRAF-3
TRAF3

A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signaling and activation of MITOGEN-ACTIVATED PROTEIN KINASES.


Encephalitis Virus, Japanese
Japanese B Encephalitis Virus
Japanese Encephalitis Virus
Virus, Japanese Encephalitis

A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent.


Trichomoniasis
Infections, Trichomonas
Trichomonas Infections

Infections in birds and mammals produced by various species of Trichomonas.


Synaptic Terminals
Nerve Endings, Presynaptic
Presynaptic Terminals
Axon Terminals
Synaptic Boutons

The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.


Cation Exchangers (Resins)
Cation Exchange Resins

High molecular weight insoluble polymers which contain functional anionic groups that are capable of undergoing exchange reactions with cations.


Chromosome 10
Chromosomes, Human, Pair 10

A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.


Lipoprotein
Circulating Lipoproteins
Lipoproteins

Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.


ADP-Ribosylation Factor
ARF Protein Cofactor
ADP-Ribosylation Factors

MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(ADP-RIBOSE) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. They are involved in vesicle trafficking and activation of PHOSPHOLIPASE D. This enzyme was formerly listed as EC 3.6.1.47


Pancreatitis, Chronic
Chronic Pancreatitis

INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.


Escherichia coli Vaccines
Escherichia coli Vaccine
E coli Vaccines

Vaccines or candidate vaccines used to prevent or treat both enterotoxigenic and enteropathogenic Escherichia coli infections.


Focal Adhesion Protein-Tyrosine Kinase Family

A family of non-receptor, PROLINE-rich protein-tyrosine kinases.


The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.


Negatrons
Positrons
Electrons
Fast Electrons

Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.


Guanosine 5'-Diphosphate 3'-Diphosphate
Guanosine Tetraphosphate
Guanosine 3'-Diphosphate 5'-Diphosphate

Guanosine 5'-diphosphate 2'(3')-diphosphate. A guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis. Synonym: magic spot I.


Alternate Binaural Loudness Balance Test

Tests for measuring loudness recruitment.


Pericardiostomy
Pericardial Window Technics
Pericardial Window Techniques

Surgical construction of an opening or window in the pericardium. It is often called subxiphoid pericardial window technique.


Carduus
Thistle, Plumeless
Thistle, Musk

A plant genus of the family ASTERACEAE. Members contain arctiin and onopordopicrin.


Phosphoric acid 2,2-dichloroethenyl dimethyl ester

An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.


The region in the abdomen extending from the thoracic DIAPHRAGM to the plane of the superior pelvic aperture (pelvic inlet). The abdominal cavity contains the PERITONEUM and abdominal VISCERA, as well as the extraperitoneal space which includes the RETROPERITONEAL SPACE.


Nutrition Science
Nutrition Sciences
Nutritional Sciences
Nutritional Science

The study of NUTRITION PROCESSES as well as the components of food, their actions, interaction, and balance in relation to health and disease.


Disintegrin and Metalloproteinase Domain-Containing Protein 10

A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.


Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.


Meningitis, Escherichia coli
Escherichia coli Meningitis

A form of gram-negative meningitis that tends to occur in neonates, in association with anatomical abnormalities (which feature communication between the meninges and cutaneous structures) or as OPPORTUNISTIC INFECTIONS in association with IMMUNOLOGIC DEFICIENCY SYNDROMES. In premature neonates the clinical presentation may be limited to ANOREXIA; VOMITING; lethargy; or respiratory distress. Full-term infants may have as additional features FEVER; SEIZURES; and bulging of the anterior fontanelle. (From Menkes, Textbook of Child Neurology, 5th ed, pp398-400)


Congenital structural abnormalities of the skin.


A brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations. (From Miall's Dictionary of Chemistry, 5th ed; Hawley's Condensed Chemical Dictionary, 12th ed,).


Cicatrix, Hypertrophic
Scars, Hypertrophic

An elevated scar, resembling a KELOID, but which does not spread into surrounding tissues. It is formed by enlargement and overgrowth of cicatricial tissue and regresses spontaneously.


Takus Cerulein Ceruletid Caerulein Ceruletide FI-6934

A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.


Farm Workers
Ranchers
Agricultural Workers
Farmworkers
Farmers

Persons who cultivate land or crops, or raise LIVESTOCK.


Injury, Third Cranial Nerve
Oculomotor Nerve Trauma
Oculomotor Nerve Contusion
Oculomotor Nerve Injury
Third-Nerve Palsy, Traumatic
Oculomotor Nerve Avulsion
Traumatic Third-Nerve Palsy
Oculomotor Nerve Injuries
Third-Nerve Trauma
Injury, Cranial Nerve III
Third Cranial Nerve Injuries
Cranial Nerve III Injury
Third Cranial Nerve Injury
Oculomotor Neuropathy, Traumatic
Oculomotor Nerve Transection

Traumatic injuries to the OCULOMOTOR NERVE. This may result in various eye movement dysfunction.


Peroxisome Proliferator-Activated Receptor gamma

A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.


A plant genus of the family Plantaginaceae. Members contain linarin (also called acaciin).


Proteins produced from GENES that have acquired MUTATIONS.


Atrioventricular Conduction Block
Atrioventricular Block
AV Block

Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.


Mink enteritis virus
Infectious Enteritis Virus of Mink

A species of the genus PARVOVIRUS and a host range variant of FELINE PANLEUKOPENIA VIRUS. It causes a highly contagious inflammatory gastroenteritis (MINK VIRAL ENTERITIS). In addition to mink, this virus can also infect cats and dogs.


Visco Supplements
Viscosupplement
Viscosupplements

Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS.


Minnesota Multiphasic Personality Inventory

A personality inventory consisting of statements to be asserted or denied by the individual. The patterns of response are characteristic of certain personality attributes.


Carboxylic acids that have a homocyclic ring structure in which all the ring atoms are carbon.


Disclosure
Information Disclosure
Financial Disclosure

Revealing of information, by oral or written communication.


Proprotein Convertase, Subtilisin-Kexin Type 9

A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR (LDLR); the VLDL receptor, and the APOLIPOPROTEIN E RECEPTOR. It also regulates neuronal APOPTOSIS.


Public attitudes toward health, disease, and the medical care system.


A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.


Biperiden, 1R-(1 alpha,2 alpha(R*),4 alpha)-Isomer

Biperiden, 1S-(1 alpha,2 alpha(R*),4 alpha)-Isomer

A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.


Chromosomes, Artificial, P1 Bacteriophage

Artificial Chromosomes, P1 Bacteriophage

Chromosomes, P1 Bacteriophage Artificial

DNA constructs that are derived from the DNA of BACTERIOPHAGE P1. They can carry large amounts (about 100-300 kilobases) of other sequence for a variety of bioengineering purposes.


Defoliants, Chemical
Chemical Defoliants

Herbicides that remove leaves from trees and growing plants. They may be either organic or inorganic. Several of the more persistent types have been used in military operations and many are toxic. (From Hawley's Condensed Chemical Dictionary, 11th ed)


Lymphocytic Leukemia
Leukemia, Lymphoid
Leukemia, Lymphocytic
Lymphoid Leukemia

Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.


Airway Hyper-Responsiveness
Respiratory Hypersensitivity
Hypersensitivity, Respiratory

A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.


Glyceric acids where two of the hydroxyl groups have been replaced by phosphates.


The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.


Activin Receptors, Type I
Activin Receptor-Like Kinases, Type I

One of the two types of ACTIVIN RECEPTORS or activin receptor-like kinases (ALK'S). There are several type I activin receptors. The major active ones are ALK-2 (ActR-IA) and ALK-4 (ActR-IB).


BVP-4
Bovine Papillomavirus Type 4
Bovine papillomavirus 4

A type of XIPAPILLOMAVIRUS causing alimentary carcinoma in cattle. It is related to Bovine papillomavirus 3.


Pyroptosomes Inflammasomes Inflammasome Pyroptosome

Multiprotein complexes that mediate the activation of CASPASE-1. Dysregulation of inflammasomes has also been linked to a number of autoinflammatory and autoimmune disorders.


Doppler Ultrasonography, Duplex
Ultrasonography, Doppler, Duplex
Duplex Doppler Ultrasonography
Duplex Ultrasonography, Doppler
Ultrasonography, Doppler Duplex
Doppler Duplex Ultrasonography
Ultrasonography, Duplex Doppler

Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.


A protein involved in transport between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS. This enzyme was formerly listed as EC 3.6.1.47.


A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. It occurs frequently intramuscularly where it may be mistaken for a sarcoma. It appears also in the jaws and the skin. (From Stedman, 25th ed)


Carbohydrate Metabolism, Inborn Error
Carbohydrate Metabolism, Inborn Errors

Dysfunctions of CARBOHYDRATE METABOLISM resulting from inborn genetic mutations that are inherited or acquired in utero.


EphA7 Receptor
EphA7 Protein
Receptor Tyrosine Kinase Cek11
Receptor, EphA7
Cek11 Kinase

An eph family receptor found widely expressed in embryo tissues, including the NERVOUS SYSTEM. In the BRAIN high levels of EphA7 expression occurs in the anterior tectum, medulla, RHOMBENCEPHALON, and SUBCOMMISSURAL ORGAN. Several isoforms of the protein occur due to multiple alternative spicing of the EphA7 mRNA.


Trepanation Trepanning Trephining Trephination

The removal of a circular disk of the cranium.


Trauma Severity Index
Trauma Severity Indices
Trauma Severity Indexes

Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.


Pentanucleotide Repeats
Simple Sequence Repeats
Simple Repetitive Sequence
Tetranucleotide Repeats
Microsatellites
Short Tandem Repeats
Microsatellite Markers
Microsatellite Repeats

A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).


Plasma Thromboplastin Antecedent Deficiency

A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.


Th17 Cells
TH-17 Cells
Type 17 Helper T Cells
T Helper 17 Cells

A subset of helper-effector T-lymphocytes which synthesize and secrete INTERLEUKINS IL-17; IL-17F; and IL-22. These cytokines are involved in host defenses and tissue inflammation in autoimmune diseases.


Protein Chain Termination, Translational

Peptide Chain Termination, Translational

Chain Termination, Peptide, Translational

A process of GENETIC TRANSLATION whereby the terminal amino acid is added to a lengthening polypeptide. This termination process is signaled from the MESSENGER RNA, by one of three termination codons (CODON, TERMINATOR) that immediately follows the last amino acid-specifying CODON.


Biocompatible Materials
Bioartificial Materials
Hemocompatible Materials
Biomaterials

Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.


Bone Mineral Content
Bone Density
Bone Mineral Density

The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.


Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.


Apolipoprotein L1
ApoL1 Protein
ApoL Protein
Apolipoprotein L

An ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS .


CD4 Receptors
T4 Antigens, T-Cell
Receptors, CD4
CD4 Antigen
Surface CD4 Receptor
Antigens, CD4
Receptors, Surface CD4
CD4 Molecule
CD4 Antigens

55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.


Cardiomyoplasty, Dynamic
Dynamic Cardiomyoplasty
Cardiomyoplasty

An operation that uses stimulated latissimus dorsi muscle (SKELETAL MUSCLE VENTRICLE) to assist cardiac function. The latissimus dorsi muscle is mobilized from the chest wall and moved into the thorax through the bed of the resected 2nd or 3rd rib. The muscle is then wrapped around the left and right ventricles and stimulated to contract during cardiac systole by means of an implanted burst-stimulator. (Stedman, 26th ed)


Wissler's Syndrome
Wissler-Fanconi Syndrome
Subsepsis Hyperergica
Subsepsis Allergica

A rheumatic syndrome of possibly allergic origin, usually affecting children and adolescents, and characterized by high fever, exanthema, arthralgia, leukocytosis, and increased sedimentation rate.


Immuno-Receptor Tyrosine-Based Inhibition Motif

Immune Receptor Tyrosine-Based Inhibition Motif

Immunoreceptor Tyrosine-Based Inhibition Motif

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.


Zigadenus
Death Camas
Camas, Death
Zygadenus

A plant genus of the family Melanthiaceae that is fatally toxic to grazing animals. The name is similar to another plant called Camas (CAMASSIA).


A family of extracellular proteins that are related structurally to LAMININ. They function as CHEMOTACTIC FACTORS for CELL MIGRATION and AXON GUIDANCE, acting as chemoattractants for some cell types, and as chemorepellents for others.


An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).


A synaptic membrane protein involved in MEMBRANE FUSION of SYNAPTIC VESICLES with the presynaptic membranes. It is the prototype member of the R-SNARE PROTEINS.


Imagery, Psychotherapeutic
Psychotherapy Imagery
Imagery, Guided
Imagery Psychotherapy
Guided Imagery
Psychotherapeutic Imagery
Directed Reverie Therapy
Imagery, Psychotherapy
Imagery (Psychotherapy)

The use of mental images produced by the imagination as a form of psychotherapy. It can be classified by the modality of its content: visual, verbal, auditory, olfactory, tactile, gustatory, or kinesthetic. Common themes derive from nature imagery (e.g., forests and mountains), water imagery (e.g., brooks and oceans), travel imagery, etc. Imagery is used in the treatment of mental disorders and in helping patients cope with other diseases. Imagery often forms a part of HYPNOSIS, of AUTOGENIC TRAINING, of RELAXATION TECHNIQUES, and of BEHAVIOR THERAPY. (From Encyclopedia of Human Behavior, vol. 4, pp29-30, 1994)


1,4,5-InsP3
Myo-Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Triphosphate
1,4,5-IP3
Myoinositol 1,4,5-Triphosphate
Inositol 1,4,5-Trisphosphate

Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.


Feedback (Learning)
Formative Feedback
Constructive Feedback

Information communicated to the learner that is intended to modify the learner’s thinking or behavior for the purpose of improving learning.


3D Echocardiography
Echocardiography, Three-Dimensional
Three-Dimensional Echocardiography
Echocardiography, 3-D
Echocardiography, 3D
3-D Echocardiography

Echocardiography amplified by the addition of depth to the conventional two-dimensional ECHOCARDIOGRAPHY visualizing only the length and width of the heart. Three-dimensional ultrasound imaging was first described in 1961 but its application to echocardiography did not take place until 1974. (Mayo Clin Proc 1993;68:221-40)


A class of natural cyclic peptide antibiotics produced by certain subspecies of STREPTOMYCES. They include two structurally unrelated components, STREPTOGRAMIN GROUP A and STREPTOGRAMIN GROUP B, which generally act synergistically to inhibit bacterial growth.


Hypertrophy, Right Ventricular
Ventricular Hypertrophy, Right
Right Ventricular Hypertrophy

Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality.


Receptors, Dopamine D5
Dopamine D1B Receptor
Dopamine D5 Receptor
Dopamine D5 Receptors

A subtype of dopamine D1 receptors that has higher affinity for DOPAMINE and differentially couples to GTP-BINDING PROTEINS.


VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.


MAP Kinase Kinase Kinase 2
MEKK2 Protein Kinase
MEKK-2 Protein Kinase
MEK Kinase 2
MAP3K2 Protein Kinase
MEKK2 Protein

A 70-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 5. It is activated during the cellular response to GROWTH FACTORS, oxidative stress, and hyperosmotic conditions.


Postcesarean Section
Abdominal Delivery
C-Section (OB)
Caesarean Section
Cesarean Section
Delivery, Abdominal

Extraction of the FETUS by means of abdominal HYSTEROTOMY.


A developmental malformation of the heart characterized by a twisted but not defective atrioventicular connection. The abnormal rotation of the ventricular mass around its long axis results in the crossing of the inflow streams of the two ventricles. Other features include hypoplasia of the TRICUSPID VALVE and RIGHT VENTRICLE.


Oral Surgery
Surgery, Maxillofacial
Exodontics
Maxillofacial Surgery
Surgery, Oral

A dental specialty concerned with the diagnosis and surgical treatment of disease, injuries, and defects of the human oral and maxillofacial region.


Histiocytic Necrotising Lymphadenitis
Histiocytic Necrotizing Lymphadenitis
Kikuchi Necrotizing Lymphadenitis
Kikuchi-Fujimoto's Disease
Kikuchi-Fujimoto Disease
Kikuchi's Disease
Kikuchi Disease
Nosocomial Kikuchi's Disease
Lymphadenitis, Histiocytic Necrotizing

Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue.


ACTR2 Protein
Actin-Related Protein 2
Arp2 Protein

A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.


Phosphatidylserines
Phosphatidylserine
Serine Phosphoglycerides
Phosphatidyl Serine
Phosphatidyl Serines

Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a SERINE moiety.


Hyper-IgM Immunodeficiency Syndrome, Type 1

An X-linked hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding CD40 LIGAND.


The dilatation of the aortic wall behind each of the cusps of the aortic valve.


HMGA1c Protein
AT-Hook 1c Protein, High Mobility Group

An AT-hook-containing (AT-HOOK MOTIFS) nuclear protein that may be involved in retinoid-dependent transcriptional activity.


Systematic efforts to assist individuals in selecting an occupation or suitable employment on the basis of aptitude, education, etc.


A plant genus of the family EUPHORBIACEAE that is the source of tung oil and a phorbol diester (PHORBOL ESTERS).


Dental Facility
Facility, Dental
Facilities, Dental
Dental Facilities

Use for material on dental facilities in general or for which there is no specific heading.


The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.


A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.


Anders Syndrome
Lipomatosis Dolorosa
Dercum Disease
Dercum's Disease
Adipose Tissue Rheumatism
Adiposis Dolorosa
Adiposalgia
Morbus Dercum
Ander's Syndrome
Decum-Vitaut Syndrome

A rare disease characterized by multiple tumor-like fatty deposits that press on nerves in various sites causing pain and weakness. Often these lipoma-like structures are located on the trunk and limbs but not on the face and hands.


Sinus Augmentation Therapy
Maxillary Sinus Floor Augmentation
Sinus Floor Augmentation

Guided BONE TRANSPLANTATION of the MAXILLARY SINUS surface with a BONE SUBSTITUTE grafting. It increases the bone volume at the site of the DENTAL IMPLANT and helps stabilize it.


Nuclear Waste
Radioactive Waste
Hazardous Waste, Radioactive

Liquid, solid, or gaseous waste resulting from mining of radioactive ore, production of reactor fuel materials, reactor operation, processing of irradiated reactor fuels, and related operations, and from use of radioactive materials in research, industry, and medicine. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


A subclass of nematodes characterized by reduced or absent caudal papillae and an excretory system lacking lateral canals. Its organisms are usually infective to their final host.


Contraceptive History
History, Reproductive
Birth History
Pregnancy History
Reproductive History

An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage.


TLR9 Receptor
CD289 Antigen
TLR9 Protein
Toll-Like Receptor 9

A pattern recognition receptor that binds unmethylated CPG CLUSTERS. It mediates cellular responses to bacterial pathogens by distinguishing between self and bacterial DNA.


Transference, Psychology
Psychological Transference
Transference (Psychology)

The unconscious transfer to others (including psychotherapists) of feelings and attitudes which were originally associated with important figures (parents, siblings, etc.) in one's early life.


Sperm Whale
Physeter catodon
Physeter macrocephalus

The species Physeter catodon (also called Physeter macrocephalus), in the family Physeteridae. The common name is derived from the milky wax substance in its head (spermaceti). The species also produces an intestinal secretion AMBERGRIS, which was previously used in perfumes. The sperm whale is the largest toothed MAMMAL in the world.


1,3,7-Trimethylxanthine
Quick-Pep
Caffeine
Coffeinum N
Dexitac
Coffeinum Purrum
No Doz
Percutaféine
Vivarin
Percoffedrinol N
Caffedrine
Durvitan

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.


Neurotransmitter Transporter Proteins
Neurotransmitter Transport Proteins
Neurotransmitter Transporters

Membrane transport proteins found predominately in NEURONS and neuroendocrine cells that facilitate neurotransmitter transport. They include two distinct families of proteins that transport NEUROTRANSMITTERS across the PLASMA MEMBRANE and that transport NEUROTRANSMITTERS into SECRETORY VESICLES.


Artificial Liver
Liver, Artificial
Bioartificial Liver

Devices for simulating the activities of the liver. They often consist of a hybrid between both biological and artificial materials.


Cell Separation
Cell Segregation
Isolation, Cell
Cell Isolation

Techniques for separating distinct populations of cells.


Competence, DNA Transformation
DNA Transformation Competence

The ability of bacterial cells to take up exogenous DNA and be genetically transformed by it.


Pharmacy Administration
Administrations, Pharmacy
Pharmacy Administrations
Administration, Pharmacy

The business and managerial aspects of pharmacy in its broadest sense.


Organogenesis, Plant
Plant Organ Formation
Plant Organ Development

Transformative processes which occur in cells and tissues to produce differentiated plant organs.


Receptors, Progesterone
Receptors, Progestin
Progesterone Receptor
Progestin Receptors
Progesterone Receptors

Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.


Historical Trauma
Historic Trauma
Intergenerational Trauma
Transgenerational Trauma
Historical Psychological Trauma

Clinical distress among descendants of survivors of mass trauma, as if they had suffered through the same extreme historic circumstances. Symptoms may persist through generations.


Leucovorin, Monopotassium Salt, (S)-Isomer

Leucovorin, Calcium (1:1) Salt, (S)-Isomer

A folate analog consisting of the pharmacologically active isomer of LEUCOVORIN.


A plant species of the genus VICIA, family FABACEAE. The seed is used for food and contains THIOCYANATES such as prunasin, cyanoalanine, cyanogen, and vicine.


An N-methylated indoleamine derivative and serotonergic hallucinogen which occurs naturally and ubiquitously in several plant species including Psychotria veridis. It also occurs in trace amounts in mammalian brain, blood, and urine, and is known to act as an agonist or antagonist of certain SEROTONIN RECEPTORS.


Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.


Works about published pieces of paper or other material, usually printed on one side and intended to be read unfolded and usually intended to be posted, publicly distributed, or sold, e.g., proclamations, handbills, newssheets, etc.


An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.


Avatec
Lasalocid
Ro 2-2985
X-537A
Lasalocid A

Cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry.


NIH-3T3 Cells
NIH 3T3 Cells
3T3 Cells, NIH

A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)


Filopodia
Reticulopodia
Axopodia
Microspikes, Cell Surface
Pseudopodium
Lobopodia
Lamellipodia
Pseudopodia

A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.


The forepart of the foot including the metatarsals and the TOES.


Triazide Trichlormethiazide Trichloromethiazide Aquazide Naqua

A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)


Receptors, Adipokine
Adipokine Receptors

Cell surface receptors for ADIPOKINES, cytokines secreted by the ADIPOCYTES.


Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.


Xylulose
Lyxulose
Xylulose, (D-threo)-Isomer
Xylulose, (L-threo)-Isomer


People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.


First Nation Peoples
Indigenous Peoples
Native Peoples

Descendants who self-identify as members of a group who inhabited a country or region at the time when people of different cultures or ethnic origins arrived. They often maintain their distinct language, culture, and beliefs.


Cryptophthalmos with Other Malformations

Rare autosomal recessive congenital malformation syndrome characterized by cryptophthalmos, SYNDACTYLY and UROGENITAL ABNORMALITIES. Other anomalies of bone, ear, lung, and nose are common. Mutations on FRAS1 and FREM2 are associated with the syndrome.


Derivatives of orthoaminobenzoic acid that have a phenyl group bound to the orthoamino nitrogen. Members modulate ION CHANNELS and are used as ANTI-INFLAMMATORY AGENTS.


Membrane Potential, Mitochondrial
Delta Psi M
DeltaPsi M
Mitochondrial Transmembrane Potential
DeltapsiM
Mitochondrial Membrane Potential

The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.


Inositol Phospholipids
PtdIns
Phosphatidylinositols
Inositol Phosphoglycerides
Phosphatidylinositol
Phosphatidyl Inositol
Phosphoinositides
Inositide Phospholipids

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids.


Receptors, 5-HT-2
5-HT-2 Receptors
Serotonin-2 Receptors
Serotonin 5-HT2 Receptors
Receptors, Serotonin S2
Serotonin S2 Receptors
Receptors, Serotonin, 5-HT2
Receptors, Serotonin-2
Serotonin Receptors, 5-HT2

A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to the GQ-G11 G-PROTEINS resulting in increased intracellular levels of INOSITOL PHOSPHATES and free CALCIUM.


INDEL Mutation
Insertion-Deletion Mutation

A mutation named with the blend of insertion and deletion. It refers to a length difference between two ALLELES where it is unknowable if the difference was originally caused by a SEQUENCE INSERTION or by a SEQUENCE DELETION. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a FRAMESHIFT MUTATION.


Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).


The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.


Chloretone
Chlorbutol
Acetonchloroform
Chlorobutanol, Anhydrous
Chlorobutanol
Trichlorbutanol

A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics.


TRF1 Protein
TTAGGG Repeat Binding Factor 1
TERF1 Protein
PIN2 Protein
Telomeric Repeat Binding Protein 1

An alternatively spliced form of telomeric repeat binding protein 1. In human it lacks 20 amino acids.


Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.


The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.


Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.


CFL1 Protein
N-Cofilin
Non-Muscle Cofilin
Cofilin 1

Cofilin 1 is a member of the cofilin family of proteins that is expressed in non-muscle CELLS. It has ACTIN depolymerization activity that is dependent on HYDROGEN-ION CONCENTRATION.


P450 CYP2B6 Inducers
Cytochrome P-450 CYP2B6 Inducers
CYP2B6 Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP2B6.


Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.


Myocardia
Myocardium
Cardiac Muscle
Muscle, Cardiac
Muscle, Heart

The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.


Vagal Body
Glomus Aorticum
Glomus Vagale
Aortic Bodies
Aortic Glomus

Small clusters of chemoreceptive and supporting cells located near the ARCH OF THE AORTA; the PULMONARY ARTERIES; and the CORONARY ARTERIES. The aortic bodies sense PH; CARBON DIOXIDE; and OXYGEN concentrations in the BLOOD and participate in the control of RESPIRATION. The aortic bodies should not be confused with the PARA-AORTIC BODIES in the abdomen (which are sometimes also called aortic bodies).


Polymer of polytetrafluoroethylene and carbon filaments; porous biocompatible material used in orofacial and middle ear reconstruction and as coating for metal implants.


Permeability, Cell Membrane
Cell Membrane Permeability

A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.


The posterior of the three primitive cerebral vesicles of an embryonic brain. It consists of myelencephalon, metencephalon, and isthmus rhombencephali from which develop the major BRAIN STEM components, such as MEDULLA OBLONGATA from the myelencephalon, CEREBELLUM and PONS from the metencephalon, with the expanded cavity forming the FOURTH VENTRICLE.


Tetrabromocresolsulfonphthalein
Bromocresol Green
Bromcresol Green

An indicator and reagent. It has been used in serum albumin determinations and as a pH indicator.


Chromosomes, Human, Pair 11
Chromosome 11

A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.


Methiothepin Maleate
Metitepine
Methiothepine
Methiothepin

A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.


The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).


A plant genus of the family MORACEAE. Members contain maclurin, antifungal chalcones, and other compounds.


Sulfamethoxazole Gantanol Sulphamethoxazole Sulfisomezole Sulfamethylisoxazole

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)


3-Hydroxy-3-methylpentanedioic Acid
3-Hydroxy-3-methylglutaric Acid
beta-Hydroxy-beta-Methylglutarate
Meglutol

An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.


Calcium Pyrophosphate Deposition Disease

Calcium Pyrophosphate Dihydrate Deposition

Presence of CALCIUM PYROPHOSPHATE in the connective tissues such as the cartilaginous structures of  joints. When accompanied by GOUT-like symptoms, it is referred to as pseudogout.


Polyprenol Derivatives
Polyisoprenols
Polyisoprenoid Alcohols
Polyprenols
Long Chain Isoprenoid Alcohols
Polyprenoids

Long chain isoprene compounds that include a hydroxyl group at the terminal carbon atom.


Deoxyribonucleic acid that makes up the genetic material of archaea.


A netrin that binds the DCC RECEPTOR or UNC5 receptors, resulting respectively in axon attraction or repulsion. Its interaction with these receptors also prevents APOPTOSIS; it may function as a tumor suppressor protein.


Globulins, Immune
Immunoglobulin
Immunoglobulins
Immune Globulins

Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.


Gliosarcoma
Glioblastoma with Sarcomatous Component
Sarcomatous Glioma

Rare mixed tumors of the brain and rarely the spinal cord which contain malignant neuroectodermal (glial) and mesenchymal components, including spindle-shaped fibrosarcoma cells. These tumors are highly aggressive and present primarily in adults as rapidly expanding mass lesions. They may arise in tissue that has been previously irradiated. (From Br J Neurosurg 1995 Apr;9(2):171-8)


Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).


Acyl Coenzyme A
Long-Chain Acyl CoA
Fatty Acyl CoA
Acyl CoA

S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.


An infant during the first 28 days after birth.


A plant genus of the family FUMARIACEAE that contains fumariline and other isoquinoline alkaloids.


Rare autosomal recessive disease with variable expressions. Clinical features of the disease include variable ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL; bamboo hair (trichorrhexis invaginata); and ATOPIC DERMATITIS. The disease is caused by mutations in the SPINK5 gene.


Tinea Capitis Profunda
Kerion Celsi
Trichophytia Profunda Capitis
Tinea Capitis
Trichophytia Profunda Barbae

An inflammatory manifestation of tinea capitis with a pronounced swelling that develops into suppurative central and indurated peripheral area called kerion.


A family of bivalve MOLLUSKS with heart-shaped shells, commonly known as cockles. Unlike most BIVALVES, cockles are hermaphroditic.


Insulin-Like Growth Factor Binding Protein 1

One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)


Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.


Discoidin Domain Receptor Family, Member 1 Protein

Discoidin Domain Receptor Tyrosine Kinase 1

A discoidin domain receptor for FIBRILLAR COLLAGEN that functions in a variety of cellular processes. For example, it regulates cell attachment to the EXTRACELLULAR MATRIX, remodeling of the extracellular matrix, CELL MIGRATION; CELL DIFFERENTIATION; CELL PROLIFERATION; and CELL SURVIVAL.


Bacterial Polysaccharides
Polysaccharides, Bacterial

Polysaccharides found in bacteria and in capsules thereof.


Schools, Veterinary
Veterinary Schools
Veterinary School
School, Veterinary

Educational institutions for individuals specializing in the field of veterinary medicine.


CX3CL1 Chemokine
Chemokine CX3CL1
Neurotactin
Fractalkine
Chemokine (C-X3-C Motif) Ligand 1

A CX3C chemokine that is a transmembrane protein found on the surface of cells. The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. The membrane form of the protein may also play a role in cell adhesion.


Infections, Coxsackievirus
Infections, Coxsackie Virus
Coxsackievirus Infections
Coxsackie Virus Infections

A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.


Subdural Hematoma, Traumatic
Subdural Hematoma
Hematoma, Subdural
Hemorrhage, Subdural

Accumulation of blood in the SUBDURAL SPACE between the DURA MATER and the arachnoidal layer of the MENINGES. This condition primarily occurs over the surface of a CEREBRAL HEMISPHERE, but may develop in the spinal canal (HEMATOMA, SUBDURAL, SPINAL). Subdural hematoma can be classified as the acute or the chronic form, with immediate or delayed symptom onset, respectively. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.


A developmental deformity of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward. (Dorland, 27th ed)


SR-Rich Splicing Proteins
Serine-Arginine-Rich Splicing Proteins
Serine-Arginine Splicing Factors

A family of regulatory factors essential for constitutive and alternative splicing in RNA metabolism.


Local Government
County Government
Government, Local
Municipal Government
Metropolitan Government
City Government

Smallest political subdivisions within a country at which general governmental functions are carried-out.


Lymphoma, Lymphocytic, Diffuse, Well-Differentiated

Diffuse Well-Differentiated Lymphocytic Lymphoma

Lymphoma, Small Lymphocytic, Plasmacytoid

Lymphocytic Lymphoma, Diffuse, Well-Differentiated

Lymphoma, Lymphocytic, Well Differentiated

Lymphocytic Lymphoma, Diffuse, Well Differentiated

Lymphocytic Lymphoma, Well Differentiated

Lymphoma, Lymphocytic, Diffuse, Well Differentiated

A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.


Solute Carrier Family 7-(Cationic Amino Acid Transporter, y+ System), Member 1

A high-affinity, low capacity system y+ amino acid transporter found ubiquitously. It has specificity for the transport of ARGININE; LYSINE; and ORNITHINE. It may also act as an ecotropic leukemia retroviral receptor.


Mutant Strains of Mice
Mouse, Mutant Strain
Mutant Mouse Strain
Mice, Mutant Strains
Mutant Strain of Mouse

Mice bearing mutant genes which are phenotypically expressed in the animals.


A genus of parasitic nematodes that causes TRICHINELLOSIS in man and other animal.


A carbodiimide that is used as a chemical intermediate and coupling agent in peptide synthesis. (From Hawley's Condensed Chemical Dictionary, 12th ed)


The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.


Methods of preparing tissue specimens for visualization using an electron microscope, usually a scanning electron microscope. The methods involve the creation of exact copies of the specimens by making a mold or cast (i.e., replica) of the specimen.


GTP-Binding Protein alpha Subunits
GTP-Binding Protein alpha Subunit
G-Protein alpha Subunit

The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.


D-Amino Acid Dehydrogenase
D-Amino-Acid Oxidase
dextro-Amino Acid Oxidase


Dental Faculty
Faculty, Dental
Dental Faculties
Faculties, Dental

The teaching staff and members of the administrative staff having academic rank in a dental school.


Phosphinic Acid
Phosphinic Acids
Hypophosphorous Acids

Inorganic or organic derivatives of phosphinic acid, H2PO(OH). They include phosphinates and phosphinic acid esters.


Saint Anthony's Fire
St. Anthony's Fire
Ergot Poisoning
Saint Anthonys Fire
Ergotism
Poisoning, Ergot
St. Anthonys Fire

Poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.


beta1-Adrenergic Antagonists
Adrenergic beta-1 Receptor Blockers
Adrenergic beta1-Antagonists
Adrenergic beta-1 Antagonists
beta-1 Adrenergic Blocking Agents
Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.


TNF Receptor-Associated Protein 1
TNF Receptor-Associated Factor 1
TRAF1

A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 2 to inhibit APOPTOSIS.


Organisms of the INSECTA class that are used as food or are suitable as a nutritional source, especially by humans.


Oculomotor Nerve
Nervus Oculomotorius
Cranial Nerve III
Nerve III
Third Cranial Nerve

The 3d cranial nerve. The oculomotor nerve sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye. It also sends parasympathetic efferents (via the ciliary ganglion) to the muscles controlling pupillary constriction and accommodation. The motor fibers originate in the oculomotor nuclei of the midbrain.


An aromatic ketone containing the aniline structure (ANILINE COMPOUNDS).


TR beta
Receptors beta, Thyroid Hormone
NR1A2 Gene Products
Thyroid Hormone Receptor beta
Thyroid Hormone Receptor beta-1
ERBA2 Gene Products
Thyroid Hormone Receptors beta
Thyroid Hormone Receptor beta-2
THRB Gene Products
c-erbA beta

An isoform produced by alternative splicing.


Enterobacteria phage lambda
Phage lambda
lambda Phage
Bacteriophage lambda
Coliphage lambda

A temperate inducible phage and type species of the genus lambda-like viruses, in the family SIPHOVIRIDAE. Its natural host is E. coli K12. Its VIRION contains linear double-stranded DNA with single-stranded 12-base 5' sticky ends. The DNA circularizes on infection.


Osterix Protein
Sp7 Transcription Factor

An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.


DNA, Concatenated
Concatenated DNA
DNA, Concatemers

Head to tail array of covalently joined DNA sequences generated by concatenation. Concatenated DNA is attached end to end in contrast to CATENATED DNA which is attached loop to loop.


Neuritis, Experimental Autoimmune
Neuritis, Autoimmune, Experimental
EAN (Experimental Allergic Neuritis)
Neuritis, Experimental Allergic
Experimental Autoimmune Neuropathy
Autoimmune Neuritis, Experimental
Experimental Autoimmune Neuritis
Experimental Allergic Neuritis
EAN (Experimental Autoimmune Neuritis)
Allergic Neuritis, Experimental

An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)


A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.


Developed Countries
Industrialized Countries
Industrialized Nations
Developed Nations

Countries that have reached a level of economic achievement through an increase of production, per capita income and consumption, and utilization of natural and human resources.


Antigens, CD197
Receptors, CCR7
CD197 Antigen
CD197 Antigens
CCR7 Receptors
CC Chemokine Receptor CCR7
CC Chemokine Receptor 7

CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.


Dihydrohydroxycodeinone
Dinarkon
Oxycontin
Pancodine
Eucodal
Oxycodone
Oxycodone Hydrochloride
Oxycone
Theocodin
Dihydrone
Oxiconum
Oxycodeinon


MAP Phosphatase-1
MAPK Phosphatase
Map Kinase Phosphatase 1
MKP-1 Phosphatase
CL100 Phosphatase
Externally Regulated Phosphatase (ERP)
3CH134 Phosphatase
Mitogen-Activated Protein Phosphatase-1
Dual Specificity Phosphatase 1

A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES and JNK MITOGEN-ACTIVATED PROTEIN KINASES.


Ostamer Spandex Polyisocyanates Pellethane Polyurethanes

A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.


Traumatic Carotid-Cavernous Sinus Fistula

An acquired or spontaneous abnormality in which there is communication between CAVERNOUS SINUS, a venous structure, and the CAROTID ARTERIES. It is often associated with HEAD TRAUMA, specifically basilar skull fractures (SKULL FRACTURE, BASILAR). Clinical signs often include VISION DISORDERS and INTRACRANIAL HYPERTENSION.


The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.


beta-Ara A
alpha-Ara A
Vidarabine
9-beta-D-Arabinofuranosyladenine
9-beta-Arabinofuranosyladenine
Ara-A
Vira-A
Arabinosyladenine
Adenine Arabinoside
Arabinofuranosyladenine
alpha-D-Arabinofuranosyladenine
Ara A

A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.


Rhythmic compression of the heart by pressure applied manually over the sternum (closed heart massage) or directly to the heart through an opening in the chest wall (open heart massage). It is done to reinstate and maintain circulation. (Dorland, 28th ed)


Adrenal Rest Tumor
Adrenal Cortical Rest Tumor

Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.


Plants or plant parts which are harmful to man or other animals.


External Ear Cartilage
Ear Cartilages
Ear Cartilage
Auricular Cartilage

Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.


Stem Cell Assays
Colony Forming Units Assays
Colony-Forming Units Assays
Clonogenic Cell Assays
Colony-Forming Units Assay
Clonogenic Cell Assay
Stem Cell Assay

A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.


Alouatta caraya
Black Howler Monkey, Paraguayan
Mono Aullador
Black-and-Gold Howler Monkeys
Paraguayan Black Howler Monkey

A species of the genus ALOUATTA, family ATELIDAE, inhabiting the forests of South America. Although sometimes known as black howler only adult males have black hair and adult females and juveniles are gold in color. Closely related A. pigra in Central America and A. nigerrima in the Amazon are also called black howlers.


Volar Ligament, Toe
Toe Volar Plate
Plantar Ligament
Ligamenta Tarsometatarsea Plantaria
Plantar Plate
Toe Volar Ligament
Ligamenta Plantaria

Fibrocartilaginous ligament at the metatarsophalangeal and the interphalangeal joint of the toe.


Abortion, Veterinary
Veterinary Abortion

Premature expulsion of the FETUS in animals.


Latent Tuberculosis Infection
Latent Tuberculosis

The dormant form of TUBERCULOSIS where the person shows no obvious symptoms and no sign of the causative agent (Mycobacterium tuberculosis) in the SPUTUM despite being positive for tuberculosis infection skin test.


Antibiotics, Cephalosporin
Cephalosporanic Acids
Cephalosporins

A family of organic compounds that are composed of a dihydrothiazine ring and a beta-lactam ring.


Actinoid Series Elements
Actinoids
Metals, Actinide
Metals, Actinoid
Actinides

A series of radioactive elements from ACTINIUM, atomic number 89, to and including LAWRENCIUM, atomic number 103.


Nuclear Respiratory Factor
Nuclear Respiratory Factors

A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.


A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.


Co-Immunoprecipitation
Immunoprecipitation
Immune Precipitation

The aggregation of soluble ANTIGENS with ANTIBODIES, alone or with antibody binding factors such as ANTI-ANTIBODIES or STAPHYLOCOCCAL PROTEIN A, into complexes large enough to fall out of solution.


The lateral extension of the spine of the SCAPULA and the highest point of the SHOULDER.


Receptors, Stretch, Pulmonary
Pulmonary Stretch Receptors
Receptors, Pulmonary Stretch
Stretch Receptors, Lung
Receptors, Stretch, Lung
Lung Stretch Receptors
Stretch Receptors, Pulmonary

Stretch receptors found in the bronchi and bronchioles. Pulmonary stretch receptors are sensors for a reflex which stops inspiration. In humans, the reflex is protective and is probably not activated during normal respiration.


Spinal Cord Regeneration
Spinal Cord Repair

Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.


The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.


Group II Chaperonins
Type II Chaperonins
Group II Chaparonins

A subcategory of chaperonins found in ARCHAEA and the CYTOSOL of eukaryotic cells. Group II chaperonins form a barrel-shaped macromolecular structure that is distinct from GROUP I CHAPERONINS in that it does not utilize a separate lid like structure to enclose proteins.


A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.


Receptor, PAR-2
PAR-2 Receptor
Proteinase Activated Receptor 2
Receptor, Trypsin
Trypsin Receptors
PAR2 Receptor
Protease-Activated Receptor 2
Trypsin Receptor

A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.


Shadowing Technique, Histology
Shadowing (Histology)
Shadowing Technique (Histology)
Shadowing, Histology

The technique of spraying a tissue specimen with a thin coat of a heavy metal such as platinum. The specimen is sprayed from an oblique angle, which results in the uneven deposition of the coating. The varying thicknesses create a shadow effect and give a three-dimensional appearance to the specimen.


Food prepared for consumption without exposure to heat.


RNA Polymerase I
RNA Polymerase A
DNA-Dependent RNA Polymerase I

A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. The enzyme functions in the nucleolar structure and transcribes DNA into RNA. It has different requirements for cations and salts than RNA polymerase II and III and is not inhibited by alpha-amanitin.


Small Nucleolar Ribonucleoproteins
snoRNP
Ribonucleoproteins, Small Nucleolar

Nucleolar RNA-protein complexes that function in pre-ribosomal RNA processing.


The triad of benign FIBROMA or other ovarian tumors with ASCITES, and HYDROTHORAX due to large PLEURAL EFFUSIONS.


Mesoplastics
Plastic Microparticles
Plastic Nanoparticles
Microplastics

Plastic particles, less than 5 millimeters in diameter, that are generated from the degradation of larger pieces or are manufactured to be microstructures or smaller.


Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.


Secretion Systems, Type VII
Type 7 Secretion Systems
ESX Secretion Systems
Secretion Systems, Type 7
T7SS Secretion System
Secretion Systems, ESX
Type VII Secretion Systems

Bacterial secretion systems found in bacteria that have a MYCOLIC ACID-containing outer membrane such as MYCOBACTERIACEAE; Corynebacteriaceae; and NOCARDIACEAE. These are also known as ESX secretion systems because the first to be discovered is involved in secreting major virulence factors EsxA and EsxB. There are several subtypes of T7SSs including ESX-1, ESX-2, ESX-3, ESX-4, and ESX-5 secretion systems. The subtypes share some core components including an inner membrane channel-forming ATPase complex, a membrane-anchored mycosin, and a second channel that spans the outer mycolic acid-containing membrane.


Regulatory Genes
Regulator Gene
Gene, Regulator
Regulator Genes
Genes, Regulator

Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.


Flanking Region, 3'
3' Flanking Sequence
3' Flanking Region

The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located.


Energy transmitted from the sun in the form of electromagnetic radiation.


Dicarboxylic Acid Transporters
Dicarboxylate Carrier
Dicarboxylic Acid Transport Proteins
Dicarboxylate Transport Protein
Dicarboxylate-Binding Protein
Dicarboxylate Transporter

A family of organic anion transporters that specifically transport DICARBOXYLIC ACIDS such as alpha-ketoglutaric acid across cellular membranes.


Triticosecale
Triticale
Triticum x Secale

A CEREAL GRAIN plant resulting from a cross between TRITICUM and SECALE CEREALE.


Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.


Anaplasma phagocytophilum
Cytoecetes phagocytophila
HGE Agent
Ehrlichia equi
Ehrlichia phagocytophila

A species of gram-negative bacteria in the genus ANAPLASMA, family ANAPLASMATACEAE, formerly called Ehrlichia phagocytophila or Ehrlichia equi. This organism is tick-borne (IXODES) and causes disease in horses and sheep. In humans, it causes human granulocytic EHRLICHIOSIS.


Jaw Relation Record
Record, Jaw Relation
Records, Jaw Relation
Sirognathography
Bite Registration
Axiography

A registration of any positional relationship of the mandible in reference to the maxillae. These records may be any of the many vertical, horizontal, or orientation relations. (Jablonski, Illustrated Dictionary of Dentistry)


HTLV I Associated T Cell Leukemia Lymphoma

Human T Lymphotropic Virus-Associated Leukemia-Lymphoma

Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated

Leukemia Lymphoma, T Cell, Acute, HTLV I Associated

Human T Lymphotropic Virus Associated Leukemia Lymphoma

T Cell Leukemia Lymphoma, HTLV I Associated

Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.


Vaginal Spermicides
Spermicidal Contraceptive Agents
Contraceptive Agents, Spermatocidal
Spermatocidal Agents
Spermicidal Agents
Spermatocidal Drugs
Spermatocides

Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.


Patched Receptors
Patched Protein
Patched Receptor
Patched Sonic Hedgehog Receptors

A family of 12-pass transmembrane proteins originally identified in Drosophila that are receptors for HEDGEHOG PROTEINS. They have important roles in regulating CELL PROLIFERATION; CELL DIFFERENTIAION; and BODY PATTERNING and may also function as TUMOR SUPPRESSOR PROTEINS.


Transcriptional Silencer Elements
Silencer Elements, Transcriptional
Silencing Elements
Silencer Elements

Nucleic acid sequences that are involved in the negative regulation of GENETIC TRANSCRIPTION by chromatin silencing.


X-ray screening of large groups of persons for diseases of the lung and heart by means of radiography of the chest.


Thymopoietin Pentapeptide
TP-5
Thymopentin
Timunox

Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.


Crescent-shaped cartilaginous tissue interposed between two articulating bones.


Microchip Analysis
Microchip Analytical Procedures

The preparation and analysis of samples on miniaturized devices.


A heterogeneous mixture of glycoproteins responsible for the gel structure of egg white. It has trypsin-inhibiting activity.


The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.


Aortopulmonary Septal Defect
Septal Defect, Aortopulmonary
Septal Defects, Aorticopulmonary
Septal Defect, Aorticopulmonary
Aorticopulmonary Septal Defect
Aortopulmonary Septal Defects
Septal Defects, Aortopulmonary
Aorticopulmonary Septal Defects

A developmental abnormality in which the spiral (aortopulmonary) septum failed to completely divide the TRUNCUS ARTERIOSUS into ASCENDING AORTA and PULMONARY ARTERY. This abnormal communication between the two major vessels usually lies above their respective valves (AORTIC VALVE; PULMONARY VALVE).


A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.


A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.


A condition characterized by the presence of multiple diverticuli in the walls of an organ.


5-Methoxy Psoralen
Bergapten
5-Methoxypsoralen
Pentaderm

A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.


Medieval Literature
Literature, Medieval

Writings originating in the 5th century A.D. through the 15h century.


Aminolevulinic Acid Dehydratase
Porphobilinogen Synthase
ALA-Dehydrase
Aminolevulinate Hydro-Lyase
delta-Aminolevulinic Acid Dehydratase
delta-Aminolevulinate Dehydratase

An enzyme that catalyzes the formation of porphobilinogen from two molecules of 5-aminolevulinic acid. EC 4.2.1.24.


Community centers for older adults and providers of resources for the community. In addition to providing services and activities for older adults that reflect the community's diversity, they link participants with resources offered by other agencies.


Interleukin Enhancer Binding Factor 2
ILF2 Protein
Nuclear Factor 45 Protein
NF45 Protein

A protein subunit that takes part in forming nuclear factor 90 protein complexes.


Noise present in occupational, industrial, and factory situations.


Hepatoma, Benign
Adenoma, Hepatocellular
Adenoma, Liver Cell


SIDS
SID
Sudden Infant Death Syndrome
Death, Sudden Infant
Sudden Infant Death
Crib Death
Cot Death

The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)


Habituation, Psychophysiologic
Habituation, Psychophysiological
Psychophysiologic Habituation
Psychophysiological Habituation
Habituation (Psychophysiology)

The disappearance of responsiveness to a repeated stimulation. It does not include drug habituation.


Low Angle Scattering
Small Angle Scattering
Scattering, Small Angle
Scattering, Low Angle

Scattering of a beam of electromagnetic or acoustic RADIATION, or particles, at small angles by particles or cavities whose dimensions are many times as large as the wavelength of the radiation or the de Broglie wavelength of the scattered particles. Also know as low angle scattering. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Small angle scattering (SAS) techniques, small angle neutron (SANS), X-ray (SAXS), and light (SALS, or just LS) scattering, are used to characterize objects on a nanoscale.


Antigens, CD99
CD99 Antigen
CD99 Molecule
MIC2 Protein
12E7 Antigen
12E7 Protein
E2 Antigen
T-Cell Surface Glycoprotein E2

A cell adhesion molecule that, in humans, is encoded by a gene on the PSEUDOAUTOSOMAL REGION of SEX CHROMOSOMES. It functions in CELL ADHESION of T-LYMPHOCYTES and ROSETTE FORMATION by ERYTHROCYTES. It is also involved in the migration of LEUKOCYTES through the ENDOTHELIUM BASEMENT MEMBRANE. The 12E7 antigen co-localizes with, but functions independently of PECAM-1.


Endothelium, Lymphatic
Lymphatic Endothelium

Unbroken cellular lining (intima) of the lymph vessels (e.g., the high endothelial lymphatic venules). It is more permeable than vascular endothelium, lacking selective absorption and functioning mainly to remove plasma proteins that have filtered through the capillaries into the tissue spaces.


Limonene Hydroxylases
(S)-Limonene 6-Monooxygenase
(S)-Limonene 7-Monooxygenase
(R)-Limonene 6-Monooxygenase
Limonene Monooxygenases

Members of the P-450 enzyme family that take part in the hydroxylation of limonene.


Parvovirus B19 Infection
Fifth Disease
Erythema Infectiosum

Contagious infection with human B19 Parvovirus most commonly seen in school age children and characterized by fever, headache, and rashes of the face, trunk, and extremities. It is often confused with RUBELLA.


Microsomal Monooxygenases
Xenobiotic Monooxygenases
Aryl Hydrocarbon Hydroxylases

Monooxygenases that oxidize exogenous substrates.


Geriatric long-term care facilities which provide supervision and assistance in activities of daily living with medical and nursing services when required.


Activation-Inducible Lymphocyte Immunomediatory Molecule

A costimulatory receptor that is specific for INDUCIBLE T-CELL CO-STIMULATOR LIGAND. The receptor is associated with a diverse array of immunologically-related effects including the increased synthesis of INTERLEUKIN 10 in REGULATORY T-LYMPHOCYTES and the induction of PERIPHERAL TOLERANCE.


Injuries, Preconception
Preconception Injuries

Damages to reproductive health prior to conception (FERTILIZATION), a legal term for torts liability concerning environmental safety issues. Preconception injuries may involve either the male or the female, such as chromosomal mutations in the OVA or the SPERMATOZOA.


Squamous Cell Carcinoma of the Head and Neck

Carcinoma, Squamous Cell of Head and Neck

Squamous Cell Carcinoma of Head and Neck

The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.


Eastern Equine Encephalomyelitis Virus Infection

A form of arboviral encephalitis (primarily affecting equines) endemic to eastern regions of North America. The causative organism (ENCEPHALOMYELITIS VIRUS, EASTERN EQUINE) may be transmitted to humans via the bite of AEDES mosquitoes. Clinical manifestations include the acute onset of fever, HEADACHE, altered mentation, and SEIZURES followed by coma. The condition is fatal in up to 50% of cases. Recovery may be marked by residual neurologic deficits and EPILEPSY. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)


Ribonucleic acid in archaea having regulatory and catalytic roles as well as involvement in protein synthesis.


Quinestrol
Ethinyl Estradiol 3-Cyclopentyl Ether
Estrovis

The 3-cyclopentyl ether of ETHINYL ESTRADIOL. After gastrointestinal absorption, it is stored in ADIPOSE TISSUE, slowly released, and metabolized principally to the parent compound. It has been used in ESTROGEN REPLACEMENT THERAPY. (From AMA Drug Evaluations Annual, 1992, p1011)


Viral Hepatitis Vaccines
Hepatitis, Viral, Vaccines

Any vaccine raised against any virus or viral derivative that causes hepatitis.


2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.


Informatics Applications, Medical
Medical Informatics Applications
Applications, Medical Informatics
Application, Medical Informatics

Automated systems applied to the patient care process including diagnosis, therapy, and systems of communicating medical data within the health care setting.


A complex process that involves the proliferation of MEGAKARYOCYTES in BONE MARROW, their differentiation in size and ploidy, and maturation before the release of functional BLOOD PLATELETS.


An opioid analgesic, MU OPIOID RECEPTOR agonist, and noradrenaline reuptake inhibitor that is used in the treatment of moderate to severe pain, and of pain associated with DIABETIC NEUROPATHIES.


Harvey Sarcoma Virus
Harvey murine sarcoma virus

A replication-defective mouse sarcoma virus (SARCOMA VIRUSES, MURINE) first described by J.J. Harvey in 1964.


Perioperative Nursing
Nursing, Perioperative
Surgical Nursing
Perianesthesia Nursing

Nursing care of the surgical patient before, during, and after surgery.


A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.


Vaginal Cervicectomy
Cervicectomy
Vaginal Trachelectomy
Trachelectomy

Surgical removal or resection of the CERVIX UTERI.


Infections, Picornaviridae
Infections, Picornavirus
Picornavirus Infections
Picornaviridae Infections

Virus diseases caused by the PICORNAVIRIDAE.


The variety of all native living organisms and their various forms and interrelationships.


Fibroblast Growth Factor 8b
Androgen-Induced Growth Factor
Fibroblast Growth Factor 8

A fibroblast growth factor that preferentially activates FIBROBLAST GROWTH FACTOR RECEPTOR 4. It was initially identified as an androgen-induced growth factor and plays a role in regulating growth of human BREAST NEOPLASMS and PROSTATIC NEOPLASMS.


Intratracheal Anesthesia
Endotracheal Anesthesia
Anesthesia, Endotracheal
Anesthesia, Intratracheal

Procedure in which an anesthetic such as a gas or mixture of gases is inhaled through a tube into the lungs.


The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.


Glycyram
Arthrodont
Po 12
Jintan
Glycyrrhetinic Acid
Rhetinic Acid
Glyciram
Uralenic Acid
Enoxolone
Glycyrrhetic Acid

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.


Rotating column of air extending from a thunderstorm to the ground. Tornadoes generally produce damage paths of 100 yards wide or less, with path lengths of a couple miles.


Barmah Forest Virus Infection
Alphavirus Infections
Alpha Virus Infections
Mayaro Virus Infection
Infections, Alphavirus
O'nyong-nyong Virus Infection
Ross River Virus Infection

Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.


Tetanus Toxins
Clostridial Neurotoxin
Tetanus Toxin
Clostridium tetani Toxin

Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.


Visna Virus
Maedi-Visna Virus
Visna-maedi virus
Maedi Virus

A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), that can cause chronic pneumonia (maedi), mastitis, arthritis, and encephalomyelitis (visna) in sheep. Maedi is a progressive pneumonia of sheep which is similar to but not the same as jaagsiekte (PULMONARY ADENOMATOSIS, OVINE). Visna is a demyelinating leukoencephalomyelitis of sheep which is similar to but not the same as SCRAPIE.


X Ray Emission Spectrometry, Electron Microscopic

Spectrometry, X-Ray Emission, Electron Probe

X-Ray Emission Spectrometry, Electron Microscopic

Spectrometry, X-Ray Emission, Electron Microscopic

X-Ray Microanalysis, Electron Microscopic

Microscopy, Electron, X-Ray Microanalysis

Spectrometry, X Ray Emission, Electron Microscopic

X-Ray Emission Spectrometry, Electron Probe

Spectrometry, X Ray Emission, Electron Probe

X Ray Emission Spectrometry, Electron Probe

Identification and measurement of ELEMENTS and their location based on the fact that X-RAYS emitted by an element excited by an electron beam have a wavelength characteristic of that element and an intensity related to its concentration. It is performed with an electron microscope fitted with an x-ray spectrometer, in scanning or transmission mode.


Allylnormorphine
Lethidrone
Nalorphine Hydrobromide
Nalorphine, L-tartrate (1:1)
Nalorphine, (14 alpha)-Isomer
Nalorphine
Nalorphine Hydrochloride

A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.


Deoxyribonucleic acid that makes up the genetic material of algae.


Health Services Geographic Accessibility

The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.


Lemierre Disease
Lemierre's Disease
Lemierre's Syndrome
Lemierre Syndrome
Postanginal Sepsis

A superinfection of the damaged oropharyngeal mucosa by FUSOBACTERIUM NECROPHORUM leading to the secondary septic THROMBOPHLEBITIS of the internal jugular vein.


A plant genus of the family MORACEAE that is widely planted for shade.


Peritoneal Effusion
Peritoneal Fluid
Ascitic Fluid

The serous fluid of ASCITES, the accumulation of fluids in the PERITONEAL CAVITY.


Determinant, Epidemiologic
Epidemiologic Factor
Determinants, Epidemiologic
Epidemiologic Factors
Factors, Epidemiologic
Epidemiologic Determinant
Factor, Epidemiologic
Epidemiologic Determinants

Events, characteristics, or other definable entities that have the potential to bring about a change in a health condition or other defined outcome.


Projection of near-IR light (INFRARED RAYS), in the 700-1000 nm region, across an object in parallel beams to an array of sensitive photodetectors. This is repeated at various angles and a mathematical reconstruction provides three dimensional MEDICAL IMAGING of tissues. Based on the relative transparency of tissues to this spectra, it has been used to monitor local oxygenation, brain and joints.


Amyloid Fibrils
Amyloid Substance
Amyloid

A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.


Sirolimus
AY 22-989
Rapamune
Rapamycin
I-2190A

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.


Midges, Nonbiting
Chironomidae
Chironomus

A family of nonbiting midges, in the order DIPTERA. Salivary glands of the genus Chironomus are used in studies of cellular genetics and biochemistry.


Topical Drug Administration
Administration, Topical
Topical Administration
Drug Administration, Topical
Administration, Topical Drug

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.


Recurrent Laryngeal Neuropathy, Traumatic

Traumatic injuries to the RECURRENT LARYNGEAL NERVE that may result in vocal cord dysfunction.


Aplasia Pure Red Cell
Erythrocyte Aplasia
Red-Cell Aplasia, Pure
Pure Red-Cell Aplasia

Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.


Dentistry, Geriatric
Geriatric Dentistry

The branch of dentistry concerned with the dental problems of older people.


Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)


Tetragastrin
Cholecystokinin 4
CCK-4
Gastrin Tetrapeptide
CKK-4
CCK (30-33)
Cholecystokinin-Tetrapeptide
Cholecystokinin (30-33)
AOC-Tetragastrin
AOC-Tetrapeptide

L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.


Farnesyl Diphosphate Synthase
Farnesyl Diphosphate Synthetase
Farnesyl Pyrophosphate Synthetase
Geranyltranstransferase
FPP Synthetase
Geranyltransferase

An enzyme involved in the MEVALONATE pathway, it catalyses the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.


Sleep Latency
REM Sleep Latency
Sleep Onset Latency

The time it takes to reach REM SLEEP. It is typically measured by POLYSOMNOGRAPHY or EEG as a part of various sleep pattern tests (e.g., multiple sleep latency test).


Toxicity Tests, Chronic
Chronic Toxicity Tests

Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.


T11 Erythrocyte-Binding Glycoprotein
CD2 Antigens
CD2 Antigen
Antigens, CD2

Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.


HIV Integrase Inhibitors
Integrase Inhibitors, HIV

Inhibitors of HIV INTEGRASE, an enzyme required for integration of viral DNA into cellular DNA.


Pharmacoeconomics
Economics, Pharmaceutical
Pharmacy Economics
Pharmaceutical Economics

Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))


Status Asthmaticus
Asthmatic Shock
Asthmatic Crisis

A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.


ICP (Intracranial Pressure) Increase
Elevated ICP (Intracranial Pressure)
ICP (Intracranial Pressure) Elevation
Elevated Intracranial Pressure
Intracranial Pressure Increase
Intracranial Hypertension

Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.