Proton-translocating ATPases which produce ADENOSINE TRIPHOSPHATE in plants. They derive energy from light-driven reactions that develop high concentrations of protons within the membranous cisternae (THYLAKOIDS) of the CHLOROPLASTS.


Neoplasms, Oropharyngeal
Cancer of Oropharnyx
Oropharyngeal Neoplasms
Oropharyngeal Cancer
Oropharynx Neoplasms
Cancer of the Oropharynx
Oropharynx Cancer


Lectil
Betahistine Biphar
Betaserc
Betahistine Mesylate
Betavert
Fidium
Vertigon
Aequamen
Betahistine Methanesulphonate
Betahistine Dihydrochloride
Betahistine
Vasomotal
Ribrain
Betahistine Hydrochloride
Betahistine Methanesulfonate
PT-9
Melopat
Betahistin Stada
By-Vertin
Betahistine Dihydrobromide
Mersilon
Betahistin AL
Betahistin-Ratiopharm
Serc
Extovyl

A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.


Misuse, Health Services
Health Services Misuse
Abuse of Health Services
Underuse, Health Services
Health Services Underuse
Health Services Underutilization
Misuse of Health Services

Excessive, under or unnecessary utilization of health services by patients or physicians.


Percutaneous Catheter Ablation
Catheter Ablation, Transvenous
Electrical Catheter Ablation
Catheter Ablation
Catheter Ablation, Radiofrequency
Catheter Ablation, Electric
Electric Catheter Ablation
Radiofrequency Catheter Ablation
Transvenous Catheter Ablation
Catheter Ablation, Percutaneous
Ablation, Transvenous Electrical
Ablation, Catheter
Ablation, Transvenous Electric
Catheter Ablation, Electrical

Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.


Lipoma Dolorosa
Adiposis Dolorosa Type III
Familial Multiple Lipomatosis
Dercum's Disease Type III
Familial Multiple Lipomas

A rare autosomal disorder characterized by numerous encapsulated lipomas on the trunk and extremities. The lipomas are usually not painful but can cause pain when growing. In rare cases, one lipoma can become painful and progress to multiple painful lipomas; it is then referred to as Dercum's Disease Type III


Althea officinalis
Marsh Mallow
White Mallow
Marshmallow
Althaea officinalis
Althaea
Mallow, Marsh

A plant genus of the family MALVACEAE known for mucilaginous roots. The common names of hollyhock and mallow are also used for other genera of MALVACEAE.


Genes, PRAD1
bcl-1 Genes
Cyclin D1 Genes
c-bcl-1 Proto-Oncogenes
Genes, Cyclin D1
Genes, bcl-1
c-bcl-1 Genes

The B-cell leukemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 11.


Equidae
Donkeys
Equus asinus
Asses
Zebras
Ass
Mules

Non-fertile offspring of a female horse and male donkey.


Nanoarray Analytical Devices
Microarray Microchips
Microarray Analytical Devices
Microarray Analysis

The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.


Infectious Diseases, Emerging
Communicable Diseases, Re-Emerging
Infectious Diseases, Reemerging
Communicable Diseases, Reemerging
Infectious Diseases, Re-Emerging
Communicable Diseases, Emerging

Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.


Drug Stability
Drugs Shelf Lives
Drug Shelf Life
Shelf Life, Drugs

The chemical and physical integrity of a pharmaceutical product.


Tumescence, Penile
Penile Tumescence
Nocturnal Penile Tumescence
Penile Erection

The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.


Myocyte-Specific Enhancer-Binding Factor 2C

Myocyte-Specific Enhancer-Binding Factor 2A

Myocyte-Specific Enhancer-Binding Factor 2B

Myocyte-Specific Enhancer-Binding Factor 2D

Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.


Nemaline Myopathies
Autosomal Recessive Nemaline Myopathy
Nemaline Myopathy, Autosomal Dominant
Myopathy, Rod
Nemaline Rod Disease
Late Onset Nemaline Myopathy
Nemaline Myopathy, Autosomal Recessive
Adult Onset Nemaline Myopathy
Nemaline Myopathy, Late Onset
Childhood Onset Nemaline Myopathy
Autosomal Dominant Nemaline Myopathy
Nemaline Myopathy, Adult Onset
Myopathy, Nemaline
Nemaline Myopathy
Rod Myopathy
Rod Body Disease
Rod-Body Myopathy
Myopathies, Nemaline
Nemaline Body Disease
Myopathy, Rod-Body
Nemaline Myopathy, Childhood Onset

A group of inherited congenital myopathic conditions characterized clinically by weakness, hypotonia, and prominent hypoplasia of proximal muscles including the face. Muscle biopsy reveals large numbers of rod-shaped structures beneath the muscle fiber plasma membrane. This disorder is genetically heterogeneous and may occasionally present in adults. (Adams et al., Principles of Neurology, 6th ed, p1453)


Sandplay Therapy
Play Therapy
Sandplay
Therapy, Play

A therapeutic method involving the use of sandtray or sandbox, and the nonverbal imageries created by sandplay.


A pyrrolidine and benzodioxole derivative that acts a RECEPTOR, ENDOTHELIN A antagonist. It has therapeutic potential as an antineoplastic agent and for the treatment of DIABETIC NEPHROPATHIES.


Dental Implant Loading, Early
Early Dental Implant Loading
Dental Implant Loading, Immediate
Immediate Dental Implant Loading

Endosseous dental implantation where implants are fitted with an abutment or where an implant with a transmucosal coronal portion is used within 1 week to 2 months.


Chlorisondamine Dichloride
Chlorisondamine
Chlorisondamine Chloride
Ecolid

A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.


Pepleomycin
NK-631
Peplomycin
Peplomycin Sulfate
Peplomycin Sulfate (1:1)

An antineoplastic agent derived from BLEOMYCIN.


Cyclic Nucleotide Phosphodiesterases, Type 2A

Cyclic Nucleotide Phosphodiesterase PDE2 Family

A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.


Tropospheric Ozone
Low Level Ozone
Ground Level Ozone
Ozone

Ozone in the troposphere. It is considered a secondary air pollutant because it is produced by the reaction of solar ULTRAVIOLET RAYS with other AIR POLLUTANTS and because of its harmful effects on the respiratory system and the environment.


A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.


A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.


Language Disorders
Language Disorders, Acquired
Acquired Language Disorders

Conditions characterized by deficiencies of comprehension or expression of written and spoken forms of language. These include acquired and developmental disorders.


Chimeric Antigen Receptor Therapy
Immunotherapy, Adoptive Cellular
Adoptive Immunotherapy
Adoptive Cellular Immunotherapy
Cellular Immunotherapy, Adoptive
CAR T-Cell Therapy
Immunotherapy, Adoptive

Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)


Phosphoprotein p19
Op18b Protein
Alpha-Stathmin
Metablastin
Op18a Protein
Stathmin
Phosphoprotein p18
Oncoprotein 18
Leukemia-Associated Phosphoprotein p18
Beta-Stathmin
Op18 Phosphoprotein
Lap18 Protein
Prosolin

A ubiquitous phosphoprotein that serves as an intracellular substrate for a variety of SIGNAL TRANSDUCTION PATHWAYS. PHOSPHORYLATION of stathmin occurs during CELL CYCLE progression, and stathmin functions as a microtubule-destabilizing protein that promotes MICROTUBULE depolymerization during INTERPHASE and late MITOSIS. Stathmin is expressed at very high levels in a variety of human CANCERS.


Synthetic Peptide Library
Peptide Phage Display Library
Random Peptide Library
Peptide Library
Phage Display Peptide Library
Phage Display Library, Peptide
Synthetic Peptide Combinatorial Library

A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.


5 alpha-Androstane-3 beta,17 beta-diol
5 beta-Androstane-3 alpha,17 beta-diol
5alpha-Androstane-3beta,17alpha-diol
5 alpha-Androstane-3 alpha,17 beta-diol
5 Androstane 3,17 diol
Androstane-3,17-diol
5-Androstane-3,17-diol
5 alpha-Androstane-3alpha,17 beta-diol
5 alpha-Androstane-3 beta,17 alpha-diol

The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.


Vestibular Nerve Inflammation
Vestibular Nerve Neuritis
Neuronitis, Vestibular
Acute Vestibular Neuritis
Neuritis, Vestibular
Subacute Vestibular Neuritis
Epidemic Neurolabyrinthitis
Recurrent Vestibular Neuritis
Acute Peripheral Vestibulopathy
Vestibular Neuritis
Recurrent Vestibulopathy
Vestibular Neuropathy
Episodic Recurrent Vertigo
Vestibular Neuronitis

Idiopathic inflammation of the VESTIBULAR NERVE, characterized clinically by the acute or subacute onset of VERTIGO; NAUSEA; and imbalance. The COCHLEAR NERVE is typically spared and HEARING LOSS and TINNITUS do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304)


Oncogene Products v-fos
Oncogene Protein p75(gag-fos-fox)
p75 gag-fos-fox
p75(gag-fos-fox)
Oncogene Proteins fos
v-fos Proteins
fos Oncogene Proteins
Fusion Proteins, gag-fos-fox
p75(gag-fos)
Oncogene Protein p55(v-fos)
p75 gag-fos
p55(v-fos)
Oncogene Proteins v-fos

Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55-kDa protein and the FBR-MSV v-fos gene encodes a p75-kDa fusion protein.


Pulmonary Cancer
Pulmonary Neoplasms
Lung Cancer
Lung Neoplasms
Cancer of the Lung
Neoplasms, Lung
Cancer of Lung
Neoplasms, Pulmonary


NF-kappaB2
NF-kappa B p100 Precursor Protein
NF-kappaB p52
NF-kappa B p52 Subunit
NK-kappa B p52
NFKB2 Transcription Factor
NF-kappaB p52 Subunit
NF-kappaB2 p100
Transcription Factor H2TF1

NF-kappa B p100 precursor protein helps retain TRANSCRIPTION FACTOR RELB in the CYTOPLASM and its full-length form inhibits NF-kappa B signaling. It is processed by the PROTEASOME to produce NF-kappa B p52 subunit.


Gangliosidosis, Generalized GM1, Type III

Gangliosidosis, Generalized GM1, Juvenile Type

Gangliosidosis, Generalized GM1, Infantile Form

Gangliosidosis, Generalized GM1, Chronic Type

Gangliosidosis, Generalized GM1, Adult Type

An autosomal recessive neurodegenerative disorder caused by the absence or deficiency of BETA-GALACTOSIDASE. It is characterized by intralysosomal accumulation of G(M1) GANGLIOSIDE and oligosaccharides, primarily in neurons of the central nervous system. The infantile form is characterized by MUSCLE HYPOTONIA, poor psychomotor development, HIRSUTISM, hepatosplenomegaly, and facial abnormalities. The juvenile form features HYPERACUSIS; SEIZURES; and psychomotor retardation. The adult form features progressive DEMENTIA; ATAXIA; and MUSCLE SPASTICITY. (From Menkes, Textbook of Child Neurology, 5th ed, pp96-7)


DOES (Disorders of Excessive Somnolence)

Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)


gamma-Aminobutyric Acid Subtype A Receptors

Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.


Extensor Plantar Response
Babinski Sign Negative
Babinski Sign Positive
Reflex, Babinski
Babinski's Reflex
Extensor Plantar Reflex
Great Toe Paradoxical Extensor Reflex
Paradoxical Extensor Reflex, Great Toe
Reflexes, Babinski
Babinski Sign
Babinski Sign Absent
Babinski Reflexes
Babinski's Sign
Babinski Reflex

A reflex found in normal infants consisting of dorsiflexion of the HALLUX and abduction of the other TOES in response to cutaneous stimulation of the plantar surface of the FOOT. In adults, it is used as a diagnostic criterion, and if present is a NEUROLOGIC MANIFESTATION of dysfunction in the CENTRAL NERVOUS SYSTEM.


Elephantiasis Nostras Verrucosa
Endemic Elephantiasis
Microcrystal Disease
Bigfoot Disease
Endemic Non-Filarial Elephantiasis
Elephantiasis
Lymphostatic Verrucosis
Podoconiosis
Mossy foot

Nonfilarial, noninfective, usually crystalline blockage of the limb lymphatics, almost always affecting the lower limbs and especially the feet.


Glioblastoma, Retinal
Familial Retinoblastoma
Glioma, Retinal
Sporadic Retinoblastoma
Hereditary Retinoblastoma
Eye Cancer, Retinoblastoma
Neuroblastoma, Retinal
Retinoblastoma

A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)


Chondrodysplasia Punctata 2, X-Linked Dominant

X-Linked Dominant Chondrodysplasia Punctata

A heterogeneous group of bone dysplasias, the common character of which is stippling of the epiphyses in infancy. The group includes a severe autosomal recessive form (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC), an autosomal dominant form (Conradi-Hunermann syndrome), and a milder X-linked form. Metabolic defects associated with impaired peroxisomes are present only in the rhizomelic form.


Penicillin G Jenapharm
Penibiot
Pfizerpen
Pengesod
Van-Pen-G
Penilevel
Benpen
Sodiopen
Peniroger
Penicillin Grünenthal
Coliriocilina
Benzylpenicillin Potassium
Crystapen
Benzylpenicillin
Or-pen
Penicilina G Llorente
Parcillin
Sodipen
Penicillin G Potassium
Sodium Benzylpenicillin
Penicillin G
Sodium Penicillin
Penicillin G Sodium
Pekamin
Ursopen
Unicilina

A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.


Familial High Density Lipoprotein Deficiency Disease

High-Density Lipoprotein Deficiency Disease, Familial

Familial High-Density Lipoprotein Deficiency Disease

Familial alpha-Lipoprotein Deficiency Disease

Lipoprotein Deficiency Disease, HDL, Familial

alpha-Lipoprotein Deficiency Disease, Familial

Conditions with abnormally low levels of ALPHA-LIPOPROTEINS (high-density lipoproteins) in the blood. Hypoalphalipoproteinemia can be associated with mutations in genes encoding APOLIPOPROTEIN A-I; LECITHIN CHOLESTEROL ACYLTRANSFERASE; and ATP-BINDING CASSETTE TRANSPORTERS.


P2X4 Purinoceptor Agonists
P2X1 Purinoceptor Agonists
P2X7 Purinoceptor Agonists
P2X5 Purinoceptor Agonists
Purinergic P2X5 Receptor Agonists
Purinergic P2X6 Receptor Agonists
P2X6 Purinoceptor Agonists
Purinergic P2X4 Receptor Agonists
Purinergic P2X3 Receptor Agonists
Purinergic P2X Receptor Agonists
P2X Purinoceptor Agonists
Purinergic P2X1 Receptor Agonists
Purinergic P2X7 Receptor Agonists
P2X3 Purinoceptor Agonists
P2X2 Purinoceptor Agonists
Purinergic P2X2 Receptor Agonists

Compounds that bind to and stimulate PURINERGIC P2X RECEPTORS. Included under this heading are agonists for specific P2X receptor subtypes.


Receptors, Cell Surface
Endogenous Substances Receptors
Cell Surface Hormone Receptors
Receptors, Endogenous Substances
Hormone Receptors, Cell Surface
Cell Surface Receptors

Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.


A plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida, that are mostly herbs and shrubs growing in warm arid regions. Several produce GLUCOSINOLATES.


Diagnostic-Related Group
DRG
Groups, Diagnostic-Related
DRGs
Group, Diagnostic-Related
Diagnosis-Related Groups
Case Mix
Case Mixes

A system for classifying patient care by relating common characteristics such as diagnosis, treatment, and age to an expected consumption of hospital resources and length of stay. Its purpose is to provide a framework for specifying case mix and to reduce hospital costs and reimbursements and it forms the cornerstone of the prospective payment system.


Peptidoglycan immunoadjuvant originally isolated from bacterial cell wall fragments; also acts as pyrogen and may cause arthritis; stimulates both humoral and cellular immunity.


Neurofibromatosis, Central, NF 2
Acoustic Neurinoma, Bilateral
Neurofibromatosis II
Bilateral Acoustic Neurofibromatosis
Neurofibromatosis, Acoustic, Bilateral
Schwannoma, Acoustic, Bilateral
Central Neurofibromatosis
Neurofibromatosis 2
NF2 (Neurofibromatosis 2)
Acoustic Schwannomas, Bilateral
Neurofibromatosis, Central, NF2
Familial Acoustic Neuromas
Neurofibromatosis, Type 2
Neurofibromatosis, central type
Neuroma, Acoustic, Bilateral
Neurofibromatosis Type II
Neurofibromatosis Type 2
Neurofibromatosis, Central NF2
Neurofibromatosis, Type II

An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.


Neuroaspergillosis
Nervous System Invasive Aspergillosis
Aspergillosis, Nervous System Invasive

Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)


Type 1 Collagen
Collagen Type I, alpha1 Subunit
Type I Procollagen
alpha2(I)-Collagen
Collagen Type I, alpha2 Subunit
COL1A2
Procollagen Type I
alpha 2 Collagen Type I
Pro alpha 2 Collagen
Collagen Type I
Collagen alpha1(I)
alpha2 Type 1 Collagen
Collagen Type 1 alpha-2
alpha 2(I) Collagen
Type I Collagen
Collagen alpha2(I)
alpha1 Type 1 Collagen
Collagen Type I, alpha1 Chain
Pro alpha 1 Collagen
alpha-2 Type 1 Collagen
Collagen Type I, alpha2 Chain

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.


Brentan
Miconazole
Miconazole Nitrate
Monistat
R-14,889
Miconasil Nitrate
Dactarin

An imidazole antifungal agent that is used topically and by intravenous infusion.


Progressive Variant of Kozhevnikow Syndrome

Chronic Progressive Epilepsia Partialis Continua

Epilepsia Partialis Continua, Chronic Progressive

Kozhevnikow Syndrome, Progressive Variant

A variant of EPILEPSY characterized by continuous focal jerking of a body part over a period of hours, days, or even years without spreading to other body regions. Contractions may be aggravated by movement and are reduced, but not abolished during sleep. ELECTROENCEPHALOGRAPHY demonstrates epileptiform (spike and wave) discharges over the hemisphere opposite to the affected limb in most instances. The repetitive movements may originate from the CEREBRAL CORTEX or from subcortical structures (e.g., BRAIN STEM; BASAL GANGLIA). This condition is associated with Russian Spring and Summer encephalitis (see ENCEPHALITIS, TICK BORNE); Rasmussen syndrome (see ENCEPHALITIS); MULTIPLE SCLEROSIS; DIABETES MELLITUS; BRAIN NEOPLASMS; and CEREBROVASCULAR DISORDERS. (From Brain, 1996 April;119(pt2):393-407; Epilepsia 1993;34;Suppl 1:S29-S36; and Adams et al., Principles of Neurology, 6th ed, p319)


Radiation-Sensitizing Agents
Radiosensitizing Effects
Radiosensitizing Effect
Radiation-Sensitizing Effect
Radiosensitizing Drugs
Radiation-Sensitizing Drugs
Agents, Radiation-Sensitizing
Radiation Sensitizing Agents
Radiation Sensitizers
Radiation-Sensitizing Effects
Radiosensitizing Agents

Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.


A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT  that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION.


Heterogeneous-Nuclear Ribonucleoprotein Group F-H

Heterogeneous-Nuclear Ribonucleoprotein Group H

Heterogeneous-Nuclear Ribonucleoprotein H-H'-F-2H9 Family

A group of closely-related heterogeneous-nuclear ribonucleoproteins that are involved in pre-mRNA splicing.


Sulfisoxazole, Monosodium, Monomesylate Salt

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.


Glucagon-Like Peptides
Enteroglucagon
Glucagon-Like Polypeptides
Gut Glucagon
Enteroglucagons

Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.


Leopardus pardalis
Ocelots
Snow Leopards
Uncia
Leopards, Snow
Felidae
Leopards, Clouded
Uncia uncia

Genus of FELIDAE consisting of one species: the SNOW LEOPARD.


mRNA Decay
mRNA Stability
mRNA Instability
RNA Decay
RNA Degradation
mRNA Degradation
mRNA Transcript Degradation
RNA Instability
RNA Stability

The extent to which an RNA molecule retains its structural integrity and resists degradation by RNASE, and base-catalyzed HYDROLYSIS, under changing in vivo or in vitro conditions.


Myosin V2
Ventricular Cardiac beta-Myosin
Cardiac beta-Myosin
Ventricular alpha, beta- Myosin
Myosin V1
Cardiac alpha-Myosin
Ventricular Myosin
Ventricular alpha-Myosin
Ventricular Isomyosins
Ventricular Cardiac alpha-Myosin
alpha-Myosin
Ventricular beta-Myosin
beta-Myosin
Myosin V3
Ventricular Myosins
Myosin, Ventricular

A form of ventricular myosin that contains two alpha-myosin heavy chains. It has a higher ATPase activity and contracts at a faster rate than myosins containing beta-myosin heavy chains.


Frontal Linear Scleroderma en Coup de Sabre

A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.


Neoplasms, Dental Tissue
Odontogenic Tumors
Dental Tissue Neoplasms

Neoplasms produced from tooth-forming tissues.


Dideoxycytidine
Hivid
HIVID Roche
ddC (Antiviral)
Zalcitabine
NSC-606170
2',3'-Dideoxycytidine

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.


Drug Sensitivity Tests, Helminth
Parasitic Sensitivity Tests
Helminth Drug Sensitivity Tests
Protozoal Drug Sensitivity Tests
Parasite Sensitivity Tests
Protozoa Drug Sensitivity Tests
Drug Sensitivity Tests, Parasitic
Drug Sensitivity Tests, Protozoal

Tests that demonstrate the relative effectiveness of chemotherapeutic agents against specific parasites.


Hemidesmus
Hemidesmus indicus
Sarsaparilla, East Indian
Anantamul
Periploca indica

A plant genus of the family Apocynaceae. It is a source of PREGNANES and is sometimes an adulterant of commercial sarsaparilla (SMILAX).


Reflex, Anal, Absent
Palmo-Mental Reflex
Reflex, Biceps, Abnormal
Reflex, Triceps, Absent
Bulbocavernosus Reflex, Decreased
Hyporeflexia
Reflex, Gag, Absent
Reflex, Corneal, Absent
Reflex, Moro, Asymmetric
Reflex, Abnormal
Reflex, Absent
Reflex, Biceps, Decreased
Reflex, Ankle, Abnormal
Hoffman's Reflex
Abnormal Deep Tendon Reflex
Reflex, Biceps, Absent
Reflex, Pendular
Bulbocavernousus Reflex Absent
Reflex, Knee, Abnormal
Abnormal Reflex
Reflex, Acoustic, Abnormal
Reflex, Knee, Decreased
Reflex, Decreased
Reflex, Deep Tendon, Absent
Reflex, Ankle, Decreased
Reflex, Anal, Decreased
Reflex, Gag, Decreased
Reflex, Triceps, Abnormal
Hyperreflexia
Reflex, Corneal, Decreased
Abnormal Reflexes
Reflex, Triceps, Decreased
Reflex, Deep Tendon, Abnormal
Reflexes, Abnormal
Reflex, Ankle, Absent

An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.


Protein Structure, Supersecondary
Protein Motifs
Supersecondary Protein Structure
Amino Acid Motifs
AA Motifs
Motifs, Amino Acid

Three-dimensional protein structural elements that are composed of a combination of secondary structures. They include HELIX-LOOP-HELIX MOTIFS and ZINC FINGERS. Motifs are typically the most conserved regions of PROTEIN DOMAINS and are critical for domain function. However, the same motif may occur in proteins or enzymes with different functions.


Brimonidine Tartrate (1:1), (S-(R*,R*))-Isomer

A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.


Nucleus Amygdalae
Amygdaloid Body
Intercalated Amygdaloid Nuclei
Amygdaloid Nucleus
Massa Intercalata
Corpus Amygdaloideum
Amygdala
Amygdaloid Nuclear Complex
Archistriatum

Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.


Aneurysm, Posterior Communicating Artery

Outpouching of BASILAR ARTERY at the base of the skull. The basilar artery is the most important artery in the posterior cerebral circulation.


Spinal Cord Neoplasms, Primary Intramedullary

Primary Spinal Cord Neoplasms, Intramedullary

Spinal Cord Neoplasms, Intradural-Extramedullary

Intramedullary Spinal Cord Neoplasms, Primary

Intradural-Extramedullary Spinal Cord Neoplasms

Primary Intramedullary Spinal Cord Neoplasms

Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.


Nasal Decongestants
Vasoconstrictors, Nasal
Decongestants
Vasoconstrictor Agents, Nasal

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)


Antiemetic Effect
Antiemetic Effects
Antiemetics
Antiemetic Drugs
Anti-emetics
Anti-Emetic Effect
Anti-Emetic Effects
Antiemetic Agents

Drugs used to prevent NAUSEA or VOMITING.


Stoneworts Charophyta Charophyceae Charales Charophytes

A division of VIRIDIPLANTAE which is equivalent to Charophyceae in some classifications and its parent in others.


Accessory Abducens Nucleus
Central Tegmental Tract
Reticular Formation of Pons
Dorsal Part of Pons
Pontine Tegmentum
Nucleus Subceruleus
Dorsal Acoustic Stria
Paralemniscal Nucleus
Tegmentum of Pons
Pontine Reticular Formation
Pars Dorsalis Pontis
Tegmentum Protuberancial
Nuclei of the Lateral Lemniscus
Tegmentum Pontis

The dorsal region of pons bounded by the middle CEREBELLAR PEDUNCLES and the ventral part of the pons. It is continuous with the TEGMENTUM MESENCEPHALI and contains CEREBELLAR NUCLEI, lemnisci and RETICULAR FORMATION.


ETHINYL ESTRADIOL and NORGESTREL given in fixed proportions.


Robenidine Hydrochloride
Robenzidine
Cytostat
Robenidine
Robenzidene
Robenz

An anticoccidial agent mainly for poultry.


Prolecofen
Rythmol
Propafenone, (+-)-Isomer
Propamerck
Propafenone Hydrochloride, (R)-Isomer
Rytmogenat
Propafenone Hydrochloride
Norfenon
Propafenone Hydrochloride, (S)-Isomer
Propafenone, (S)-Isomer
Propafenone, (R)-Isomer
Nistaken
Rytmo-Puren
SA-79
Fenoprain
Arythmol
Cuxafenon
Propafenon AL
Baxarytmon
Rytmonorm
Propafenone
Pintoform
Propafenon Hexal
Propafenon Minden
Apo-Propafenone
Jutanorm

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.


Visual Pattern Reflex Epilepsy
Musicogenic Epilepsy
Reflex Epilepsy, Eating-Induced
Reflex Epilepsy, Cursive (Running)
Reflex Epilepsy, Visual Pattern
Immersion Related Epilepsy
Reflex Epilepsy, Musicogenic
Tactile Reflex Epilepsy
Writing-Induced Reflex Epilepsy
Audiogenic Epilepsy
Reading Epilepsy
Epilepsy, Reflex
Decision Making Reflex Epilepsy
Photosensitive Epilepsy
Reflex Epilepsy, Audiogenic
Reflex Epilepsy, Reading
Reflex Epilepsy, Photosensitive
Cursive Epilepsy
Epilepsy, Photogenic
Epilepsy, Reading
Eating-Induced Epilepsy
Reflex Epilepsy

A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)


ddNTPs
Dideoxynucleotide Triphosphates
Dideoxynucleotides

The phosphate esters of DIDEOXYNUCLEOSIDES.


A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190)


CD25-negative regulatory cells found in the mucosal immune system. They secrete IL-4; IL-10; and TGF-BETA. The natural origin of this cell type is not clear.


Anterior Pituitary Hyposecretion Syndrome

Hyposecretion Syndrome, Anterior Pituitary

Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.


Duloxetine Ethanedioate (1:1), (+-)-isomer - T353987

A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.


Sequence Alignment
Sequence Homology Determination
Determination, Sequence Homology

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.


Peer Review, Grants
Peer Review, Research
Peer Review, Publishing
Grants, Peer Review

The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.


Gliocladium virens
Hypocrea
Hypocrea virens

A genus of fungus in the family Hypocreaceae, order HYPOCREALES. Anamorphs include TRICHODERMA.


Apple
Malus domestica
Malus
Apple Tree
Crab Apple

A plant genus in the family ROSACEAE, order Rosales, subclass Rosidae. It is best known as a source of the edible fruit (apple) and is cultivated in temperate climates worldwide.


Neuropathy, Superficial Peroneal
Peroneal Nerve Entrapment
External Popliteal Neuropathy
Lateral Popliteal Neuropathy
Peroneal Nerve Diseases
Fibular Neuropathy
Peroneal Nerve Paralysis
Fibular Nerve Diseases
Foot Drop
Common Peroneal Nerve Entrapment
Peroneal Mononeuropathies
Peroneal Neuropathies
Neuropathy, Common Peroneal
Neuropathy, Deep Peroneal
Peroneal Palsy

Disease involving the common PERONEAL NERVE or its branches, the deep and superficial peroneal nerves. Lesions of the deep peroneal nerve are associated with PARALYSIS of dorsiflexion of the ankle and toes and loss of sensation from the web space between the first and second toe. Lesions of the superficial peroneal nerve result in weakness or paralysis of the peroneal muscles (which evert the foot) and loss of sensation over the dorsal and lateral surface of the leg. Traumatic injury to the common peroneal nerve near the head of the FIBULA is a relatively common cause of this condition. (From Joynt, Clinical Neurology, 1995, Ch51, p31)


Orofacial Edema, Cheilitis Granulomatosa, Facial Neuropathy

Facial Neuropathy, Cheilitis Granulomatosa, Orofacial Edema

Facial Neuropathy, Orofacial Edema, Cheilitis Granulomatosa

Cheilitis Granulomatosa, Facial Neuropathy, Orofacial Edema

Orofacial Edema, Facial Neuropathy, Cheilitis Granulomatosa

Cheilitis Granulomatosa, Orofacial Edema, Facial Neuropathy

An idiopathic syndrome characterized by one or more of the following; recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue (lingua plicata). The onset is usually in childhood and relapses are common. Cheilitis granulomatosa is a monosymptomatic variant of this condition. (Dermatol Clin 1996 Apr;14(2):371-9; Magalini & Magalini, Dictionary of Medical Syndromes, 4th ed, p531)


A 5-ALPHA-REDUCTASE INHIBITOR that is reported to inhibit both type-1 and type2 isoforms of the enzyme and is used to treat BENIGN PROSTATIC HYPERPLASIA.


Neonatal Pyruvate Dehydrogenase Complex Deficiency Disease

Juvenile Pyruvate Dehydrogenase Complex Deficiency Disease

Pyruvate Dehydrogenase Complex Deficiency Disease, Neonatal

Intermittent Ataxia with Pyruvate Dehydrogenase Deficiency

Ataxia, Intermittent, with Abnormal Pyruvate Metabolism

Ataxia, Intermittent, with Pyruvate Dehydrogenase, or Decarboxylase, Deficiency

Pyruvate Dehydrogenase Complex Deficiency Disease, Juvenile

An inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the complex leads to LEIGH DISEASE.


A hardy EDIBLE GRAIN crop, rye, grown in northern climates. It is the most frequent host to ergot (CLAVICEPS), the toxic fungus. Its hybrid with TRITICUM is TRITICALE, another CEREAL crop.


Bayesian Approach
Bayesian Forecast
Bayesian Method
Bayesian Prediction
Bayesian Analysis
Bayes Theorem
Analysis, Bayesian

A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.


Fetal Hypoxia
Anoxia, Fetal
Fetal Anoxia


Congenital Myopathy with Fiber Type Disproportion

Fiber-Type Disproportion Myopathy, Congenital

Autosomal Recessive Centronuclear Myopathy

Myopathy, Congenital, With Fiber-Type Disproportion

Myopathy, Centronuclear, Autosomal Dominant

A heterogeneous group of diseases characterized by the early onset of hypotonia, developmental delay of motor skills, non-progressive weakness. Each of these disorders is associated with a specific histologic muscle fiber abnormality.


Contusio Cerebri
Cerebellar Contusion
Cerebral Contusion
Cortical Contusion
Brain Contusion

A bruise of the brain from an impact of the skull.


Solanum lycopersicum
Tomato
Tomatoes
Lycopersicon esculentum

A plant species of the family SOLANACEAE, native of South America, widely cultivated for their edible, fleshy, usually red fruit.


Growth Factor Receptors
Trophic Factor Receptor
Receptors, Trophic Factor
Receptors, Growth Factors
Receptors, Growth Factor
Trophic Factor Receptors

Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.


Yeast Three-Hybrid System
Yeast Two-Hybrid Assay
Yeast Three-Hybrid Assay
One-Hybrid System Techniques
Reverse One-Hybrid System Techniques
Two-Hybrid Method
One-Hybrid System Technics
Two-Hybrid Assay
Tri-Hybrid System Techniques
Yeast One-Hybrid System Techniques
n-Hybrid System Techniques
Two-Hybrid System Technics
Reverse Two-Hybrid System Techniques
Three-Hybrid System Techniques
Yeast Three-Hybrid System Techniques
Yeast Two-Hybrid System Techniques
Three-Hybrid System Technics
Yeast Two-Hybrid System
Reverse Three-Hybrid System Techniques
Two-Hybrid System Techniques

Variations on the two-hybrid system technique that analyze for mutations or small molecules that interfere with or dissociate specific protein-protein interactions.


Ergotamine
Ergotamine Tartrate (2:1)
Lingraine
Cornutamine
Ergotamine Tartrate
Ergotaminine
Gynergen
Ergodryl Mono
Ergo Sanol
Ergo-Kranit
Ergostat
Ergomar

A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.


Mansonella ozzardi
Filaria demarquayi
Dipetalonema perstans
Mansonella
Tetrapetalonema
Filaria ozzardi
Mansonella perstans
Acanthocheilonema perstans

A genus of parasitic nematodes whose organisms are distributed in Central and South America. Characteristics include a smooth cuticle and an enlarged anterior end.


Traumatic Intracranial Subdural Hematoma

Intracranial Subdural Hematoma, Traumatic

Subdural Hematoma, Traumatic, Intracranial

Accumulation of blood in the SUBDURAL SPACE over the CEREBRAL HEMISPHERE.


Apolipoprotein C-I
Apolipoprotein C1
Apo C-I Precursor
Apo C-I
Pre Apo C-I
Apolipoprotein C-I Precursor

A 6.6-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS; INTERMEDIATE-DENSITY LIPOPROTEINS; and HIGH-DENSITY LIPOPROTEINS. Apo C-I displaces APO E from lipoproteins, modulate their binding to receptors (RECEPTORS, LDL), and thereby decrease their clearance from plasma. Elevated Apo C-I levels are associated with HYPERLIPOPROTEINEMIA and ATHEROSCLEROSIS.


An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.


Sound Spectrography
Speech Sonography
Sonography, Sound
Sonography, Speech

The graphic registration of the frequency and intensity of sounds, such as speech, infant crying, and animal vocalizations.


Molecular Evolution, Directed
In Vitro Molecular Evolution
Directed Molecular Evolution
Evolution, Molecular, Directed
Laboratory Molecular Evolution

The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.


Wnt beta-Catenin Signaling Pathway
Wnt Pathway, Canonical
Wnt Pathway
Wnt Signaling Pathway

A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.


Cerebroside Sulphatase Deficiency Disease

Cerebral sclerosis, Diffuse, Metachromatic Form

Metachromatic Leukodystrophy, Late Infantile

An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.


Cyclic Nucleotide Phosphodiesterases, Type 4C

Cyclic Nucleotide Phosphodiesterases, Type 4A5

Cyclic Nucleotide Phosphodiesterases, Type 4D3

Cyclic Nucleotide Phosphodiesterases, Type 4B

Cyclic Nucleotide Phosphodiesterase PDE4 Family

Type 4 Cyclic Nucleotide Phosphodiesterase

A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.


Placental Labyrinth Layer
Labyrinth of the Placenta
Chorionic Villi
Placental Villi
Labyrinthine Placenta

Chorionic villi equivalent in lower mammals (e.g., mouse and rat)


Arabidopsis thaliana Proteins
Arabidopsis Proteins
Thale Cress Proteins

Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.


Manic Disorder
Manic State
Manic-Depressive Psychosis
Bipolar Disorder
Psychoses, Manic-Depressive
Mania
Psychosis, Manic-Depressive
Affective Psychosis, Bipolar
Depression, Bipolar

A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.


Ethacrinic Acid
Ethacrynate Sodium
Hydromedin
Ethacrynic Acid
Ethacrynic Acid, Sodium Salt
Edecrin
Etacrynic Acid

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.


Standing Orders
Standing Order Prescriptions
Standing Order Prescription

Medical procedures and prescriptions regarding treatment of a patient that can be exercised by other health care personnel when predetermined conditions have been met.


Leukoencephalopathy with Vanishing White Matter

Childhood Ataxia with Diffuse Central Nervous System Hypomyelination

Childhood Ataxia with Central Nervous System Hypomyelination

Childhood Ataxia with Central Nervous System Hypomyelinization

Any of various diseases affecting the white matter of the central nervous system.


Aegiceras
Oncostemon
Loosestrife, Yellow
Myrsinaceae
Lysimachia
Primulaceae

A plant family of the order ERICALES, class MAGNOLIOPSIDA, with flowers having both stamens and pistil, producing encapsulated fruits.


Spongy Degeneration of White Matter In Infancy

Spongy Disease of Central Nervous System

Spongy Degeneration Of Central Nervous System

Spongy Degeneration of the Central Nervous System

A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)


A plant genus of the family LAMIACEAE. Members contain TRITERPENES. Heal all is another common name.


Estrogenic Compounds
Estrogen Effect
Estrogen Receptor Agonists
Estrogens
Estrogenic Agents
Estrogen
Estrogenic Effects
Estrogen Effects
Estrogenic Effect

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.


Health Psychology
Psychology, Health
Medicine, Behavioral
Behavioral Medicine

The interdisciplinary field concerned with the development and integration of behavioral and biomedical science, knowledge, and techniques relevant to health and illness and the application of this knowledge and these techniques to prevention, diagnosis, treatment, and rehabilitation.


Adjuvant Arthritis
Arthritis, Experimental
Arthritis, Collagen-Induced
Arthritis, Adjuvant
Arthritis, Adjuvant-Induced
Collagen Arthritis

An experimental model of arthritis that is induced by injecting adjuvants. These adjuvants generally consists of a mixture of light paraffin oil, emulsifying agent, and infective agents or antigens, such as killed mycobacteria or bacterial lipopolysaccharides.


Energy-Generating Resources
Secondary Energy Resources
Primary Energy Resources
Primary Energy Resource

Natural sources from which power is obtained.


A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.


Epidermolysis Bullosa Dystrophica, Cockayne-Touraine Type

Epidermolysis Bullosa Dystrophica, Dominant

Dystrophic Epidermolysis Bullosa, Autosomal Recessive

Cockayne-Touraine Type Epidermolysis Bullosa

Epidermolysis Bullosa Dystrophica, Autosomal Recessive

Epidermolysis Bullosa Dystrophica, Recessive

Epidermolysis Bullosa Dystrophica, Hallopeau-Siemens Type

Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.


Ocular Vision
Visual Light Signal Transduction
Light Signal Transduction, Visual
Vision
Vision, Ocular
Visual Transduction
Visual Phototransduction

The transducing of light energy to afferent nerve impulses in the retinal rods and cones. After light photons are absorbed by the visual photopigments, the signal is transmitted to the outer segment membrane by the cyclic GMP second messenger system, where it closes the sodium channels. This channel gating ultimately generates an action potential in the inner retina.


Screw Worm Infection
Screw Worm Myiasis
Infection, Screw Worm
Chrysomya bezziana Infestation
Chrysomya bezziana Myiasis
Cochliomyia hominivorax Infestation
Chrysomya bezziana Infection
Cochliomyia hominivorax Myiasis
Cochliomyia hominivorax Infection

Infection with larvae of the blow fly Cochliomyia hominivorax (Callitroga americanum), a common cause of disease in livestock in the southern and southwestern U.S.A.


Single-Blind Study
Single-Blind Method
Single-Masked Study
Single-Masked Method

A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.


Pentetates
DTPA
Pentaind
Pentetic Acid
Sn-DTPA
Pentacine
CaDTPA
Zinc-DTPA
DETAPAC
Pentacin
Pentetate Zinc Trisodium
Indium-DTPA
Diethylenetriamine Pentaacetic Acid
Pentetate Calcium Trisodium
CaNa-DTPA
Ca-DTPA
Penthanil
Mn-Dtpa
Calcium Trisodium Pentetate

An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.


Posture Balance
Postural Control
Postural Balance
Posture Control
Balance, Postural
Posture Equilibrium
Musculoskeletal Equilibrium
Postural Equilibrium

A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking.


Tumor-Free Margins
Resection Margin
Positive Surgical Margins
Negative Surgical Margins
Margins of Excision
Surgical Margins

The edges of tissue removed in a surgery for assessment of the effectiveness of a surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. When the margin is negative or not involved by tumor (e.g., CANCER) it suggests all of the tumor has been removed by the surgery.


Cementoplasty
Percutaneous Cementoplasty
Percutaneous Osteoplasty

Injection of BONE CEMENTS into bone to treat bone lesions.


Biologic Markers
Viral Marker
Surrogate Marker
Markers, Serum
Markers, Viral
Markers, Clinical
Marker, Immunologic
Surrogate Endpoints
Marker, Biochemical
Marker, Biological
Marker, Laboratory
Laboratory Markers
Immunologic Markers
Clinical Markers
Marker, Clinical
Markers, Immunologic
Biochemical Marker
Surrogate Endpoint
Biological Markers
Marker, Serum
Biomarkers
Markers, Biological
Surrogate Markers
Viral Markers
Surrogate End Point
Immunologic Marker
Biochemical Markers
Immune Marker
Markers, Biochemical
Laboratory Marker
Markers, Laboratory
Marker, Surrogate
Immune Markers
Markers, Surrogate
Biologic Marker
Clinical Marker
Serum Markers
Serum Marker
Surrogate End Points

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc.


Ankle Bones
Tarsus Osseus
Tarsal Bones
Os Naviculare
Cuboid Bone
Cuneiform Bones
Navicular Bone of Foot

The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.


Drug Preparation
Pharmaceutical Formulation
Drug Compounding
Drug Formulation
Drug Microencapsulation

The preparation, mixing, and assembly of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814).


Dauno-Rubidomycine
Rubomycin
Daunorubicin
Daunomycin
Rubidomycin
Daunoblastin
NSC-82151
Daunoblastine
Cerubidine
Daunorubicin Hydrochloride

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.


2-Phospho-D-Glycerate Hydro-Lyase
beta-Enolase
Phosphopyruvate Hydratase
Neuron-Specific Enolase
Enolase 2
Muscle-Specific Enolase
Non-Neuronal Enolase
Enolase 3
2-Phospho-D-Glycerate Hydrolase
Enolase
gamma-Enolase
Nervous System-Specific Enolase
alpha-Enolase
2-Phosphoglycerate Dehydratase

A hydro-lyase that catalyzes the dehydration of 2-phosphoglycerate to form PHOSPHOENOLPYRUVATE. Several different isoforms of this enzyme exist, each with its own tissue specificity.


Ligustrum lucidum
Ligustrum
Ligustri lucidi
Privet

A plant genus of the family OLEACEAE. Oleuropein, a phenolic secoiridoid glycoside, is found in the leaves.


Dipyridamole Kurantil Apo-Dipyridamole Cléridium Persantin Antistenocardin Curantil Persantine Novo-Dipiradol Cerebrovase Dipyramidole Miosen Curantyl

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)


Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester

Synthetic analogs of the naturally occurring insecticides cinerin, jasmolin, and pyrethrin. (From Merck Index, 11th ed)


Ulmus
Slippery Elm
Elm Tree
Ulmus fulva
Ulmus rubra

A plant genus of the family ULMACEAE that is susceptible to Dutch elm disease which is caused by the ASCOMYCOTA fungus, Ophiostoma.


Calcium Saccharate Anhydrous
Calcium Glucarate, Anhydrous
Glucosaccharic Acid
Tetrahydroxyadipic Acid
D-Glucaric Acid
Saccharic Acid
Glucaric Acid
Calcium Saccharate
Calcium Saccharate, Anhydrous
Calcium Glucarate
Levo-Gularic Acid
Calcium Saccharate Tetrahydrate
D-Saccharic Acid
L-Gularic Acid

A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.


B-15000
Iopamidol, (+-)-Isomer
Solutrast 370
Iopamiro
Solutrast Gastro
B-15,000
Isovue 370
Isovue
Iopamidol
Iopamidol, (R)-Isomer
Iopamidol, Sodium Salt, (S)-Isomer
Niopam
Solutrast
Gastromiro
Jopamidol
SQ 13,396

A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.


Carbonated Water
Carbonated Mineral Water
Club Soda
Seltzer Water
Sparkling Water
Soda Water

Carbonated water which also contains sodium or potassium salts.


Lumbarsacral Spondylosis
Spondylosis Deformans
Thoracic Spondylosis
Spondylosis, Cervical
Cervical Spondylosis
Spondylosis

A form of spondylosis involving the INTERVERTEBRAL DISK, including both the annulus and the nucleus of the disk. It is usually the consequence of normal aging.


Home Care Dental Devices
Dental Floss
Dental Devices, Home Care
Floss, Dental

Devices used in the home by persons to maintain dental and periodontal health. The devices include toothbrushes, dental flosses, water irrigators, gingival stimulators, etc.


Microscopy, Differential Interference Contrast

Microscopy, Nomarski Interference Contrast

The science and application of a double-beam transmission interference microscope in which the illuminating light beam is split into two paths. One beam passes through the specimen while the other beam reflects off a reference mirror before joining and interfering with the other. The observed optical path difference between the two beams can be measured and used to discriminate minute differences in thickness and refraction of non-stained transparent specimens, such as living cells in culture.


Branchiostoma nigeriense
Amphioxus
Branchiostoma
Branchiostoma floridae
Branchiostoma lanceolatum
Mediterranean Amphioxus
Florida Lancelet
Lancelets
Branchiostoma belcheri
Branchiostoma japonicum
Amphioxi
Amphioxus lanceolatus

Small fish-like marine creatures often used in phylogenetic comparative studies of CHORDATES.


Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).


Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.


United States Substance Abuse and Mental Health Services Administration

Substance Abuse and Mental Health Services Administration (U.S.)

United States Health Services and Mental Health Administration

Health Services and Mental Health Administration (U.S.)

Alcohol, Drug Abuse, and Mental Health Administration (U.S.)

An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to substance abuse and mental health. It is commonly referred to by the acronym SAMHSA. On 1 October 1992, the United States Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA) became SAMHSA.


Performance-Enhancing Drugs
Performance-Enhancing Substances
Performance-Enhancing Effect
Ergogenic Substances
Ergogenic Effects
Performance-Enhancing Effects

Agents that improve the ability to carry out activities such as athletics, mental endurance, work, and resistance to stress. The substances can include PRESCRIPTION DRUGS; DIETARY SUPPLEMENTS; phytochemicals; and ILLICIT DRUGS.


Benzethonium Chloride
Puri-Clens
Phemethryn
Benzethonium
Phemeride
Quatrachlor
Solamin
Bencetonium Chloride
Formula Magic
Hyamine 1622
Phemerol
Orchid Fresh II

Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.


Herceptin Trastuzumab Trazimera Trastuzumab-qyyp

A humanized monoclonal antibody against the ERBB-2 RECEPTOR (HER2). As an ANTINEOPLASTIC AGENT, it is used to treat BREAST CANCER where HER2 is overexpressed.


Public-Private Partnerships
Public-Private Sector Cooperation
Public-Private Cooperation
Public-Private Sector Partnerships


Taro, Giant
Alocasia
Alocasia macrorrhiza

A plant genus of the family ARACEAE. Members contain beta-glucosidases and trypsin inhibitors.


Ampelopsis
Porcelainberry Plant
Porcelain Berry Plant

A plant genus of the family VITACEAE. Members contain momordin and SITOSTEROLS.


Polyadenylic Acids
Poly A
Poly(rA)
Adenine Polynucleotides

A group of adenine ribonucleotides in which the phosphate residues of each adenine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.


Soft Coal Fly Ash
Fly Ash
Bottom Ash
Oil Fly Ash
ROFA Pollutant
Coal Ash

Fraction of soggy texture coal ash collected from top section of chimneys.


MDI (Inhalers)
Metered Dose Inhalers
Spacer-Inhalers
Inhalers, Metered Dose
Spinhalers
Spacer Inhalers

Inhalation devices with INHALATION SPACERS. They are generally used for dry powder medications.


Vaccinium macrocarpon
Cranberry
Cranberries

A plant species of the family VACCINIUM known for the sour fruit which is sometimes used for urinary tract infections.


Histamine H2 Agonists
Histamine H1 Receptor Agonist
H3 Agonists
Histamine Agonists
H1 Agonists
H2 Agonists
Histamine H1 Agonist
Histamine H2 Receptor Agonist
Histamine H2 Receptor Agonists
Histamine H1 Agonists
Histamine Agonist
Histamine H3 Agonist
Histamine H3 Receptor Agonists
H1 Agonist
Histaminergic Agonist
Histamine H1 Receptor Agonists
H2 Agonist
Histamine H3 Agonists
Histaminergic Agonists
H3 Agonist
Histamine H2 Agonist

Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.


Hereditary, Type VII, Motor and Sensory Neuropathy

Hereditary Motor and Sensory Neuropathy Type III

Hereditary Motor and Sensory Neuropathy 3

Hypertrophic Neuropathy of Dejerine-Sottas

Hereditary, Type III, Motor and Sensory Neuropathy

Hereditary Motor and Sensory Neuropathies

Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Neuropathies, Hereditary Motor and Sensory

A group of slowly progressive inherited disorders affecting motor and sensory peripheral nerves. Subtypes include HMSNs I-VII. HMSN I and II both refer to CHARCOT-MARIE-TOOTH DISEASE. HMSN III refers to hypertrophic neuropathy of infancy. HMSN IV refers to REFSUM DISEASE. HMSN V refers to a condition marked by a hereditary motor and sensory neuropathy associated with spastic paraplegia (see SPASTIC PARAPLEGIA, HEREDITARY). HMSN VI refers to HMSN associated with an inherited optic atrophy (OPTIC ATROPHIES, HEREDITARY), and HMSN VII refers to HMSN associated with retinitis pigmentosa. (From Adams et al., Principles of Neurology, 6th ed, p1343)


Genetically Engineered Animals
Animals, Transgenic
Animals, Genetically Modified
Founder Animals, Transgenic
GMO Animals
Transgenic Animals
Genetically Modified Animals

Animals, or the offspring of such animals, into which cloned genetic material has been experimentally transferred by microinjection of foreign DNA, either directly or into embryos or differentiated cell types.


Genotoxic Stress
DNA Damage
Stress, Genotoxic
DNA Injury
Injury, DNA


Caspase 10-a
Mch4 Protease
Caspase 10
Caspase 10a
Caspase 10c
Caspase 10d
Caspase 10-d
Caspase-10
Caspase 10-c

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. Caspase 10 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.


A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.


Fucus vesiculosus
Bladderwrack
Bladder Wrack
Fucus

A genus of BROWN ALGAE in the family Fucaceae. It is found in temperate, marine intertidal areas along rocky coasts and is a source of ALGINATES. Some species of Fucus are referred to as KELP.


Colony-Forming Units, Neoplastic
Tumor Initiating Cells
Tumor Stem Cells
Cancer Stem Cells
Stem Cells, Neoplastic
Neoplastic Colony-Forming Units
Neoplastic Stem Cells

Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.


EEDTs (Eosinophil Extracellular DNA Traps)

Extracellular structure primarily composed of CHROMATIN and associated PROTEASES.


Oncogene Proteins v-mil
v-mil Protein
Oncogene Proteins v-raf
Oncogene Protein mil
Protein v-mil
v-raf Kinases

A family of transforming proteins isolated from retroviruses such as MOUSE SARCOMA VIRUSES. They are viral-derived members of the raf-kinase family of serine-theonine kinases.


Viral Encephalitis, Arthropod-Borne
Arthropod-Borne Encephalitis
Encephalitis, Arbovirus
Encephalitis, Arthropod-Borne
Mosquito-Borne Encephalitis
Encephalitis, Mosquito-Borne
Encephalitis, Epidemic
Epidemic Encephalitis
Arthropod-Borne Viral Encephalitis
Arboviral Encephalitis

Infections of the brain caused by arthropod-borne viruses (i.e., arboviruses) primarily from the families TOGAVIRIDAE; FLAVIVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; and RHABDOVIRIDAE. Life cycles of these viruses are characterized by ZOONOSES, with birds and lower mammals serving as intermediate hosts. The virus is transmitted to humans by the bite of mosquitoes (CULICIDAE) or TICKS. Clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)


Fibrous Dysplasia with Pigmentary Skin Changes and Precocious Puberty

Albright's Syndrome with Precocious Puberty

FIBROUS DYSPLASIA OF BONE affecting several bones. When melanotic pigmentation (CAFE-AU-LAIT SPOTS) and multiple endocrine hyperfunction are additionally associated it is referred to as Albright syndrome.


Angiogenesis Stimulators
Angiogenesis Inducing Agents
Angiogenesis Factor
Angiogenesis Stimulating Agents
Angiogenesis Effects
Angiogenesis Inducers
Angiogenic Factor
Tumor Angiogenic Factor
Angiogenesis Effect

Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.


Switchboard Service
Service, Switchboard
Telephone

An instrument for reproducing sounds especially articulate speech at a distance. (Webster, 3rd ed)


Olfactory Bulb
Bulbus Olfactorius
Olfactory Tract
Olfactory Glomerulus
Lateral Olfactory Tract
Main Olfactory Bulb
Accessory Olfactory Bulb

Ovoid body resting on the CRIBRIFORM PLATE of the ethmoid bone where the OLFACTORY NERVE terminates. The olfactory bulb contains several types of nerve cells including the mitral cells, on whose DENDRITES the olfactory nerve synapses, forming the olfactory glomeruli. The accessory olfactory bulb, which receives the projection from the VOMERONASAL ORGAN via the vomeronasal nerve, is also included here.


Lesser Galagos
Needle-Clawed Galagos
Euoticus
Galagoides
Otolemur
Paragalago
Sciurocheirus
Galagidae
Squirrel Galagos
Greater Galagos

A family of Primates of the suborder Strepsirhini containing six genera. The family is widely distributed in Africa near Subsaharan region. The six genera are: Euoticus (needle-clawed galagos), GALAGO (bush babies), Galagoides (dwarf galagos), Otolemur (greater galagos), Paragalago and Sciurocheirus (squirrel galagos). All are primarily arboreal and nocturnal.


Follistatin-Like Protein 1
FSTL1 Gene Product
Follistatin-Like Protein 3
Follistatin-Like Secreted Glycoprotein
Follistatin-Related Protein 1
Follistatin-Related Proteins
Follistatin Secreted Related Protein
FSTL3 Gene Product
FLRG Protein

A secreted glycoprotein of approximately 28 kD, encoded by the FLRG or FSTL3 gene.


Auriculotemporal Syndrome
Hyperhidrosis, Gustatory
von Frey's Syndrome
Frey's Syndrome
Salivosudoriparous Syndrome
Auriculotemporal Nerve Syndrome
Baillarger Syndrome
Gustatory Sweating
von Frey Syndrome
Sweating, Gustatory
Frey Syndrome

An autonomic disorder characterized by excessive sweating of the forehead, upper lip, perioral region, or sternum subsequent to gustatory stimuli. The auriculotemporal syndrome features facial flushing or sweating limited to the distribution of the auriculotemporal nerve and may develop after trauma to the parotid gland, in association with PAROTID NEOPLASMS, or following their surgical removal. (From Ann Neurol 1997 Dec;42(6):973-5)


Novobiocin Calcium
Crystallinic Acid
Novobiocin Sodium
Novobiocin, Monosodium Salt
Novobiocin
Streptonivicin

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)


Enalapril Maleate
MK-421
MK421
Renitec
Renitek
Enalapril

An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.


Voltage-Gated Sodium Channel Type 8 Subunit alpha

A voltage-gated sodium channel subtype found widely expressed in neurons of the central and peripheral nervous systems. Defects in the SCN8A gene which codes for the alpha subunit of this sodium channel are associated with ATAXIA and cognitive deficits.


p120-GAP Protein
p120 GAP
p125-GAP Protein
p125 GAP
p120rasGAP
p100 GAP
p100-GAP Protein
p120 GTPase Activating Protein

A 120-kDa RAS GTPase-activating protein that binds to tyrosine phosphoproteins through its SH2 domains. The 100-kDa RNA-splicing variant (p100 GAP protein) is expressed in placenta.


A plant genus of the family LAMIACEAE. The common names of beebalm or lemonbalm are also used for MONARDA.


Retinal Vein Occlusion
Thrombosis, Retinal Vein
Central Retinal Vein Occlusion
Retinal Branch Vein Occlusion
Branch Vein Occlusion
Retinal Vein Thrombosis

Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHEROSCLEROSIS; and other CARDIOVASCULAR DISEASES.


Breast Cancer Treatment-Related Lymphedema

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical treatment (e.g., MASTECTOMY) or radiation treatment of breast cancer.


Legal Medicine
Medicine, Legal
Forensic Medicine
Medicine, Forensic

The application of medical knowledge to questions of law.


Coronavirus HKU15
Bulbul coronavirus HKU11
Coronavirus, Rabbit
Munia coronavirus HKU13
Deltacoronavirus
Rabbit Coronavirus
Coronavirus
Thrush coronavirus HKU12

A member of CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.


Sisomycin
Sisomicin
Extramycin
Sch-13475
Antibiotic 6640
4,5-Dehydrogentamicin
Siseptin
Rickamicin
Sissomicin
Sizomycin
Sisomicin Sulfate (2:5) Salt
Sisomicin Sulfate
Pathomycin

Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).


Schizosaccharomyces
Yeast, Fission
S pombe
Fission Yeast
Schizosaccharomyces pombe

A genus of ascomycetous fungi of the family Schizosaccharomycetaceae, order Schizosaccharomycetales.


24,25-Dihydroxyvitamin D 3, (3beta,5Z,7E,24R)-Isomer

A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL.


Endonuclease RhsI
Endonuclease AacI
Deoxyribonuclease BstI
BamNI Endonuclease
Endonuclease BamHI
RhsI Endonuclease
Endonuclease AliI
AaeI Endonuclease
Endonuclease GoxI
Endonuclease AccEBI
GinI Endonuclease
AliI Endonuclease
NspSAIV Endonuclease
BamHI Deoxyribonuclease
Endonuclease MleI
BstI Endonuclease
Endonuclease AaeI
AccEBI Endonuclease
Endonuclease NspSAIV
SolI Endonuclease
DNA Restriction Enzyme BamHI
Endonuclease DdsI
NasBI Endonuclease
MleI Endonuclease
Endonuclease Ali12258I
BamKI Endonuclease
DdsI Endonuclease
AacI Endonuclease
Endonuclease SolI
Endonuclease GinI
BstI Deoxyribonuclease
Endonuclease BamKI
Endonuclease GdoI
ApaCI Endonuclease
GoxI Endonuclease
Deoxyribonuclease BamHI
GdoI Endonuclease
Endonuclease BamNI
BamI Endonuclease
Endonuclease BnaI
Endonuclease NasBI
Endonuclease BamFI
BnaI Endonuclease
Endonuclease BstI
BamHI Endonuclease
Endonuclease Ali12257I
BamFI Endonuclease
Endonuclease Bst1503

One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/GATCC at the slash. BamHI is from Bacillus amyloliquefaciens N. Numerous isoschizomers have been identified. EC 3.1.21.-.


Percutaneous Absorption
Transdermal Absorption
Intracutaneous Absorption
Absorption, Skin
Intradermal Absorption
Transcutaneous Absorption
Skin Absorption


SRY (Sex Determining Region Y)-Box 21 Transcription Factor

SRY (Sex Determining Region Y)-Box 14 Transcription Factor

A subclass of SOX transcription factors that are expressed in neuronal tissue where they may play a role in the regulation of CELL DIFFERENTIATION. Members of this subclass are generally considered to be transcriptional repressors.


Droleptan Dehidrobenzperidol Inapsine Droperidol Dehydrobenzperidol

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)


Hemangioblasts
Hemogenic Endothelium
Hemangioblast
Hemogenic Endothelial Cells


Ambulances
Emergency Mobile Units
Mobile Emergency Units

A vehicle equipped for transporting patients in need of emergency care.


A cardioselective beta-1 adrenergic antagonist that has intrinsic symopathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION.


Liposarcoma, Dedifferentiated
Well Differentiated Liposarcoma
Liposarcoma, Pleomorphic
Atypical Lipomatous Tumor
Liposarcoma
Liposarcoma, Well Differentiated

A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)


Calcium Aluminosilicate Clay
Calcium Aluminosilicate
CASAD
Calcium Aluminosilicate Anti-Diarrheal

Aluminosilicate salts of calcium, the most common of which are CaAl2Si2O8 and Ca2Al2SiO7; a naturally occurring form in CLAY may be used to treat DIARRHEA.


Symmetric Diabetic Proximal Motor Neuropathy

Asymmetric Diabetic Proximal Motor Neuropathy

Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)


Proprotein Convertase, Subtilisin-Kexin Family

Proprotein Convertases, Subtilisin-Kexin Family

Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.


Threadworms
Oxyuris vermicularis
Enterobius vermicularis
Enterobius
Pinworms

A genus of intestinal nematode worms which includes the pinworm or threadworm Enterobius vermicularis.


Continuous Batch Culture
Batch Culture
Shake-Flask Culture
Fed-Batch Culture
Batch Cell Culture Techniques
Fed-Batch Culture Techniques
Batch Culture Techniques
Fed Batch Culture Techniques

Batch cell culture technique where the culture is fed with nutrients throughout the process, instead of all at once in the beginning.


Saccharopine Dehydrogenase (NADP+, L-Glutamate Forming)

Saccharopine Dehydrogenase (NAD+, L-Lysine Forming)

Saccharopine Dehydrogenase (NAD+, L-Glutamate Forming)

Saccharopine Dehydrogenase (NADP+, L-Lysine Forming)

Amine oxidoreductases that use either NAD+ (EC 1.5.1.7) or NADP+ (EC 1.5.1.8) as an acceptor to form L-LYSINE or NAD+ (EC 1.5.1.9) or NADP+ (EC 1.5.1.10) as an acceptor to form L-GLUTAMATE. Deficiency of this enzyme causes HYPERLYSINEMIAS.


hasA Enzyme
Hyaluronate Synthase
Hyaluronate Synthetase
Hyaluronan Synthase 2
Hyaluronan Synthase 1
Hyaluronan Synthase
Hyaluronic Acid Synthetase
HAS2 Protein
Hyaluronan Synthases
Hyaluronan Synthetase
HAS1 Protein
Hyaluronan Synthase 3
HAS3 Protein

Membrane-associated glucuronosyltransferases that catalyze the reaction of UDP-N-acetyl-D-glucosamine and UDP-D-glucuronate to produce HYALURONAN. HYALURONAN SYNTHASE 2 (HAS2) is essential for embryogenesis and its expression by tumor cells is associated with metastasis.


A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.


Persons specially trained and licensed in NUTRITION SCIENCES and DIETETICS.


Marmoset, Short-Tusked
Callithrix jacchus
Marmosets
Hapale
Callithrix
Marmoset, Common

A genus of the subfamily CALLITRICHINAE occurring in forests of Brazil and Bolivia and containing seventeen species.


HSP47 Heat-Shock Proteins
Heat Shock Protein 47
Heat-Shock Protein 47
Serpin H1

Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.


Adenosine Triphosphate, Magnesium Chloride

Adenosine Triphosphate, Chromium Ammonium Salt

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.


Synaptotagmin VIII
Synaptotagmin XII
Synaptotagmin IX
Synaptotagmin 11
Synaptotagmin XIV
Synaptotagmin
Synaptotagmin XV
Synaptotagmin 3
Synaptotagmin XIII
Synaptotagmin 8
Tagmin
Synaptotagmin III
Synaptotagmin XI
Synaptotagmin VII
Synaptotagmin 13
Synaptotagmin 12
SytVII Protein
Synaptotagmin 6
Synaptotagmin 14
Synaptotagmin 5
SytIV Protein
Synaptotagmin 4
Synaptotagmins
Synaptotagmin IV
Synaptotagmin VI
Synaptotagmin V
Synaptotagmin 15
Synaptotagmin 7
Synaptotagmin 9
SytXIII Protein

A family of vesicular transport proteins characterized by an N-terminal transmembrane region and two C-terminal calcium-binding domains.


Movement Disorders
Status Marmoratus
Dyskinesia Syndromes
Movement Disorder Syndromes
Etat Marbre

Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.


A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.


Minnows
Cyprinidae
Tinca tinca
Tinca
Chub
Shiner
Dace
Tench
Rutilus rutilus
Barbus
Roach (Fish)
Barbels

A genus of fish. It includes the species Tinca tinca, which is also called Tench.


Arvin IRC-50
Venacil
Arvin
Agkistrodon rhodostoma Venom Protease
Agkistrodon Serine Proteinase
Ancrod
Arwin

An enzyme fraction from the venom of the Malayan pit viper, Agkistrodon rhodostoma. It catalyzes the hydrolysis of a number of amino acid esters and a limited proteolysis of fibrinogen. It is used clinically to produce controlled defibrination in patients requiring anticoagulant therapy. EC 3.4.21.-.


Toxicodendron
Oak, Poison
Rhus toxicodendron
Ivy, Poison
Poison Ivy
Poison Oak
Poison Sumac
Sumac, Poison

A genus (formerly part of Rhus genus) of shrubs, vines, or trees that yields a highly allergenic oleoresin which causes a severe contact dermatitis (DERMATITIS, TOXICODENDRON). The most toxic species are Toxicodendron vernix (poison sumac), T. diversilobum (poison oak), and T. radicans (poison ivy). T. vernicifera yields a useful varnish from which certain enzymes (laccases) are obtained.


An inactive peptide prodrug that is slowly converted in the body to lypressin. It is used to control bleeding of ESOPHAGEAL VARICES and for the treatment of HEPATORENAL SYNDROME.


Transcutaneous Electrical Nerve Stimulation

Percutaneous Electrical Nerve Stimulation

Transcutaneous Electric Nerve Stimulation

The use of specifically placed small electrodes to deliver electrical impulses across the SKIN to relieve PAIN. It is used less frequently to produce ANESTHESIA.


Eugenic Abortion
Abortion, Eugenic
Abortion, Selective
Selective Abortion

Abortion performed because of possible fetal defects.


Tendinosis Tendinopathy Tendonopathy Tendonosis Tendonitis Tendinitis

Inflammation of TENDONS. It is characterized by the degeneration of tendons accompanied by an inflammatory repair response, fibroblastic proliferation, and formation of granulation tissue. Tendinitis is not a clinical diagnosis and can be confirmed only by histopathological findings.


Chamomile, Stinking
Camomile, Stinking
Fennel, Dog
Anthemis cotula
Mayweed, Stinking
Anthemis

A plant genus of the family ASTERACEAE that is similar to MATRICARIA but this has tiny chaffy bract scales between each pair of florets. Members contain sesquiterpene lactones. Other plants with similar common names include FERULA; FOENICULUM; MATRICARIA; CHAMAEMELUM and TRIPLEUROSPERMUM.


A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.


Hilus of the Fascia Dentata
Cornu Ammonis 4 Area
Hippocampal Sector CA4
Hilus of Dentate Gyrus
Dentate Fascia
Area Dentata
Dentate Gyrus
Hippocampal CA4 Field
CA4 of Lorente de No
CA4 Region, Hippocampal
CA4 Field of Hippocampal Formation
Hilus Gyri Dentati
Fascia Dentata
Gyrus Dentatus

A subsection of the hippocampal formation, described by Lorente de No, that composes the hilus of the DENTATE GYRUS.


Aurintricarboxylic Acid, Calcium (1:3) Salt

Aurintricarboxylic Acid, Calcium (2:3) Salt

Aurintricarboxylic Acid, Triammonium Salt

A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.


Anterior Cruciate Ligament
Cruciate Ligament, Anterior
Anterior Cranial Cruciate Ligament
Cranial Cruciate Ligament

A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.


Hepatolenticular Degeneration
Progressive Lenticular Degeneration
Hepatic Form of Wilson Disease
Wilson Disease, Hepatic Form
Wilson Disease
Hepatolenticular Degeneration Syndrome
Hepato-Neurologic Wilson Disease
Pseudosclerosis
Wilson's Disease
Cerebral Pseudosclerosis
Copper Storage Disease
Neurohepatic Degeneration
Westphal-Strumpell Syndrome
Kinnier-Wilson Disease
Hepatocerebral Degeneration

A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.


Core I Protein, Ubiquinol-Cytochrome c Reductase

Core II Protein, Ubiquinol-Cytochrome c Reductase

A dimer of CYTOCHROME B and CYTOCHROME C1.


Fir, Balsam
Abies balsamea
Abies
Fir Tree
Balsam Fir

A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. Balm of Gilead is a common example.


Corporate Ethics
Business Ethics
Ethics, Business
Ethics, Corporate

The moral obligations governing the conduct of commercial or industrial enterprises.


Histiocytic Sarcoma
True Histiocytic Lymphoma
True Malignant Histiocytosis
Histiocytosis, Malignant
Malignant Histiocytosis

A rare, usually progressive disorder comprising an invasive proliferation of neoplastic HISTIOCYTES. Many previous cases are now thought to represent ANAPLASTIC LARGE-CELL LYMPHOMA.


(15S)-Hydroxy-11 alpha, 9 alpha-(epoxymethano)prosta-5Z, 13E-dienoic Acid

9,11-Dideoxy-11 alpha,9 alpha-epoxymethanoprostaglandin F2 alpha

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)


RAD2 Homolog-1 Nuclease
Flap Endonuclease-1
Flap Endonucleases
RTH-1 Nuclease
Fen1 Protein
FEN-1

Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.


Orobanchaceae
Castilleja
Paintbrush, Indian
Indian Paintbrush

A plant genus of the family Orobanchaceae. It contains acteoside and isoacteoside (phenylethanoid glycosides).


Aromatic Amino Acid Decarboxylase Inhibitors

Compounds and drugs that block or inhibit the enzymatic action of AROMATIC AMINO ACID DECARBOXYLASES. Pharmaceutical agents in this category are used in conjunction with LEVODOPA in order to slow its metabolism.


Congenital Immunodeficiency Diseases
Primary Immunodeficiency Disorders
Primary Immunodeficiency Syndromes
Inherited Immunodeficiency Diseases
Primary Immune Deficiency Syndromes
Primary Antibody Deficiency Syndromes
Primary Immune Deficiency Diseases
Congenital Immunodeficiency Disorders
Inherited Immunodeficiency Syndromes
Primary Antibody Deficiency Disorders
Inherited Immunodeficiency Disorders
Primary Immune Deficiency
Primary Immune Deficiency Disorders
Primary Immunodeficiency Diseases
Congenital Immunodeficiency Syndromes
Primary Antibody Deficiencies

Genetic immunologic deficiency diseases and syndromes due to mutations in genes involved in IMMUNITY generally characterized by an increased susceptibility to infectious diseases. They are often associated with AUTOIMMUNE DISEASE manifestations.


An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.


Carotenoids found in fruits and vegetables. Zeaxanthin accumulates in the MACULA LUTEA.


Ascidia
Ascidiacea
Urochordates
Urochordata
Sea Squirts
Tunicata
Tunicates
Ascidians

A subphylum of chordates intermediate between the invertebrates and the true vertebrates. It includes the Ascidians.


Triticum turgidum subsp. durum
Triticum spelta
Triticum aestivum
Triticum turgidum
Wheat
Triticum
Durum Wheat
Triticum durum
Triticum vulgare

A variety which is the source of spelt (which should not be confused with oat spelt).


Family Planning Instructors
Education, Sex
Education, Family Planning
Family Planning Education
Family Planning Training
Sex Education

Education which increases the knowledge of the functional, structural, and behavioral aspects of human reproduction.


Porokeratosis Plantaris, Palmaris, Et Disseminata

Porokeratosis Plantaris Palmaris et Disseminata

Disseminated Superficial Actinic Porokeratosis

Keratoderma Palmoplantar, Punctate Type 2

Porokeratosis Palmaris et Plantaris Disseminata

Porokeratosis, Disseminated Superficial Actinic 2

Porokeratosis, Disseminated Superficial Actinic, 2

Porokeratosis, Palmar, Plantar, And Disseminated 1

The classical form of porokeratosis with isolated lesions.


Loosestrife
Purple Loosestrife
Loosestrife, Purple
Lythrum
Lythrum salicaria

A plant genus of the family LYTHRACEAE that contains ALKALOIDS.


Co-infection
Mixed Infection
Polymicrobial Infection
Coinfection
Secondary Infections
Secondary Infection

Simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses.


Respiratory Therapy
Therapy, Inhalation
Inhalation Therapy
Therapy, Respiratory

Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.


Orthosiphon aristatus
Orthosiphon stamineus
Java Tea
Orthosiphon
Clerodendranthus stamineus

A plant genus of the family LAMIACEAE that contains pimarane-type diterpenes. Several species of Orthosiphon are also called Java tea.


Acquired-Immune Deficiency Syndrome Dementia Complex

Dementia Complex, Acquired Immune Deficiency Syndrome

HIV-1-Associated Cognitive Motor Complex

A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)


Nuclear Respiratory Factor 2, Alpha Subunit

Nuclear Respiratory Factor 2, Beta Subunit

A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE. GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS, and cellular METABOLISM.


Kidney, Polycystic
Polycystic Renal Disease
Polycystic Kidney
Polycystic Kidneys
Polycystic Kidney Disease
Polycystic Kidney Diseases

Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.


S Phase Cell Cycle Checkpoints
Intra-S Checkpoints
S Phase Checkpoint
S Phase Cell Cycle Checkpoint
Intra-S Checkpoint

Cell regulatory signaling system that controls progression through S PHASE and stabilizes the replication forks during conditions that could affect the fidelity of DNA REPLICATION, such as DNA DAMAGE or depletion of nucleotide pools.


mu-Conotoxin alpha-Conotoxins alpha-Conotoxin Conotoxins mu-Conotoxins Conotoxin

Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)


Organic Chemistry Process
Organic Chemistry Processes
Organic Chemistry Concepts
Organic Chemistry Phenomenon
Organic Chemistry Phenomena

The conformation, properties, reaction processes, and the properties of the reactions of organic carbon compounds.


Surgery, Proctoscopic
Surgical Procedures, Proctoscopic
Proctoscopic Surgical Procedures
Proctoscopic Surgery
Proctoscopy

Endoscopic examination, therapy or surgery of the rectum.


Teichoic Acids
Glycerol Teichoic Acids
Glycerol Teichoic Acid

Bacterial polysaccharides that are rich in phosphodiester linkages. They are the major components of the cell walls and membranes of many bacteria.


Cardiotocogram
Cardiotocography
Electronic Fetal Monitoring
External Fetal Monitoring
Internal Fetal Monitoring
External Cardiotocography
CTG, Antepartum
Internal Cardiotocography

Monitoring of FETAL HEART frequency before birth in order to assess impending prematurity in relation to the pattern or intensity of antepartum UTERINE CONTRACTION.


Interleukin-17 Receptor E
Interleukin-17 Receptor B
Interleukin-17 Receptor
IL-17 Receptors
Antigens, CDw217
Interleukin-17 Receptor D
Interleukin-17 Receptor C
Receptors, Interleukin-17
CDw217 Antigen
Cdw217 Antigens
Interleukin-17 Receptors
Interleukin-17 Receptor A


Uterus
Fundus Uteri
Womb
Uterine Cornua
Uteri
Uterine Fundus
Uterus Cornua

The superior portion of the uterus above the uterine tube line opposite to the cervix.


Family Medical History
History Taking, Medical
Family Health History
Family History, Health
Family History, Medical
Medical History Taking

Acquiring information from a patient on past medical conditions and treatments.


Antifibrinolytics
Plasmin Inhibitor
Plasmin Inhibitors
Antifibrinolytic Agents
Antiplasmins
Antifibrinolysins

Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.


Phascolarctidae
Phascolarctos cinereus
Koala

A family of marsupials in the order Diprotodontia, native to Australia and possessing vestigial tails. There is a single living genus and species: Phascolarctos cinereus, the koala.


Genetically Engineered Plants
Plants, Transgenic
Genetically Modified Plants
GMO Plants
Plants, Genetically Modified
Transgenic Plants

Plants into which genetic material from another species has been transferred.


Developmental Disorders of Scholastic Skills

Developmental Disabilities of Scholastic Skills

Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.


Aspergillosis, Bronchopulmonary
Lung Aspergillosis
Pulmonary Aspergillosis
Bronchopulmonary Aspergilloses
Aspergilloses, Bronchopulmonary
Bronchopulmonary Aspergillosis

Infections of the respiratory tract with fungi of the genus ASPERGILLUS.


Bay-Vp-2674
Enrofloxacin
Endrofloxicin
Bay Vp 2674
Baytril

A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice.


Principal Sensory Nucleus of Trigeminal Nerve

Main Sensory Nucleus of Trigeminal Nerve

Nucleus located in the pontine tegmentum with motor neurons that innervate the muscles of the JAW through the motor portion of the TRIGEMINAL NERVE.


Tarsal Joints
Tarsal Joint
Articulationes intertarsales
Articulationes intertarseae
Intertarsal Joint

The articulations between the various TARSAL BONES. This does not include the ANKLE JOINT which consists of the articulations between the TIBIA; FIBULA; and TALUS.


A long-acting beta-2-adrenergic receptor agonist.


Ribulose-Bisphosphate Carboxylase Large Subunit

Ribulose-Bisphosphate Carboxylase Small Subunit

A carboxy-lyase that plays a key role in photosynthetic carbon assimilation in the CALVIN-BENSON CYCLE by catalyzing the formation of 3-phosphoglycerate from ribulose 1,5-biphosphate and CARBON DIOXIDE. It can also utilize OXYGEN as a substrate to catalyze the synthesis of 2-phosphoglycolate and 3-phosphoglycerate in a process referred to as photorespiration.


Thermal Water Pollution
Water Pollution
Water Pollution, Thermal

Contamination of bodies of water (such as LAKES; RIVERS; SEAS; and GROUNDWATER.)


Mobile Phone
Telephone, Cellular
Cellular Phone
Transportable Cellular Phone
Cell Phone
Mobile Telephone
Cell Phones
Portable Cellular Phone
Car Phone

Type of CELLULAR PHONE installed in a car, truck, or van. This phone is attached to the vehicle and draws power from the vehicle's battery.