Rooms, Hospital Recovery
Recovery Rooms, Hospital
Hospital Recovery Room
Hospital Recovery Rooms
Recovery Room
Room, Recovery
Rooms, Recovery
Recovery Rooms
Room, Hospital Recovery
Recovery Room, Hospital

Hospital unit providing continuous monitoring of the patient following anesthesia.


Cyclin-Dependent Protein Kinases
cdk Proteins
Cyclin-Dependent Kinases

Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.


Inorganic derivatives of ammonia by substitution of one or more hydrogen atoms with chlorine atoms or organic compounds with the general formulas R2NCl and RNCl2 (where R is an organic group).


Dialysates
Dialyzates
Dialysis Solutions

Solutions prepared for exchange across a semipermeable membrane of solutes below a molecular size determined by the cutoff threshold of the membrane material.


A membrane protein that contains multiple C2 DOMAINS. It is highly expressed in skeletal muscle and functions as a calcium ion sensor in SYNAPTIC VESICLE-PLASMA MEMBRANE fusion, as well as in SARCOLEMMA repair following mechanical stress. Mutations in the dysferlin (DYSF) gene are associated with several hereditary MUSCULAR DYSTROPHIES.


Myodystrophy
Myodystrophica
Muscular Dystrophies
Muscular Dystrophy

A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.


GATA5 Transcription Factor
GATA-5 Protein
GATA5 Protein
GATA Binding Protein 5

A GATA transcription factor that is expressed predominately in SMOOTH MUSCLE CELLS and is involved in the CELL DIFFERENTIATION of CARDIAC MYOCYTES. In the developing heart, GATA5 becomes restricted to the ENDOCARDIUM and regulates transcription of genes such as cardiac TROPONIN C.


Iridoid Glucosides
Secoiridoid Glucosides
Iridoidglucosides

A subclass of iridoid compounds that include a glucoside moiety, usually found at the C-1 position.


Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.


Reflex, Vestibuloocular
Reflexes, Vestibo-Ocular
Vestibulo-Ocular Reflex
Reflexes, Vestibuloocular
Reflex, Vestibulo-Ocular

A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS.


A form of osteosclerosis extending in a linear track mainly through one of the long bones of the upper and lower limbs.


Matrix metalloproteinases that are associated with the CELL MEMBRANE, either through transmembrane domains or GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORS. Membrane-type matrix metalloproteinases may act within the pericellular environment to influence the process of CELL MIGRATION.


Mice, Inbred DBA
Mouse, DBA
Mouse, Inbred DBA
Mice, DBA

An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS.


A pesticide or chemical agent that kills mites and ticks. This is a large class that includes carbamates, formamides, organochlorines, organophosphates, etc, that act as antibiotics or growth regulators.


Heterocyclic Cpds, 1-Ring
Heterocyclic Compounds, 1-Ring

Organic compounds that contain a ring structure made up of carbon and one or more additional elements such as nitrogen and oxygen.


Myeloblastin, Human
Neutrophil Proteinase 3, Human
PRTN3 Gene Protein
Azurophil Granule Protein 7
Myeloblastin
N-Proteinase 4
C-ANCA Antigen
Neutrophil Proteinase 4
Proteinase 3
Neutrophil Proteinase 3
Wegener Autoantigen
Leukocyte Proteinase 3

A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.


Chemistry, Inorganic
Inorganic Chemistry

A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate).


Drooping of the upper lid due to deficient development or paralysis of the levator palpebrae muscle.


Dressings, Periodontal
Periodontal Dressings

Surgical dressings, after periodontal surgery, applied to the necks of teeth and the adjacent tissue to cover and protect the surgical wound. (Boucher's Clinical Dental Terminology, 4th ed, p218)


Cannabinoid Receptor Activators
Cannabinoid Agonists
Cannabinoid Receptor Agonists

Compounds that interact with and stimulate the activity of CANNABINOID RECEPTORS.


Worms, Segmented
Annelida
Segmented Worms

A phylum of metazoan invertebrates comprising the segmented worms, and including marine annelids (POLYCHAETA), freshwater annelids, earthworms (OLIGOCHAETA), and LEECHES. Only the leeches are of medical interest. (Dorland, 27th ed)


Deficiency, Platelet Storage Pool
Storage Pool Deficiency
Storage Pool Deficiency, Platelet
Storage Pool Platelet Disease
Platelet Storage Pool Deficiencies
Platelet Storage Pool Disease
Familial Platelet Storage Pool Disease
Deficiency, Storage Pool
Acquired Storage Pool Disease
Platelet Storage Pool Deficiency

Disorder characterized by a decrease or lack of platelet dense bodies in which the releasable pool of adenine nucleotides and 5HT are normally stored.


Peptidyl-Prolyl Cis-Trans Isomerase Pin1

A highly-conserved peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated SERINE- or THREONINE-PROLINE (pSer/Thr-Pro) motifs and causes conformational changes in certain proteins associated with the CELL CYCLE. It displays a preference for an acidic residue N-terminal to the isomerized proline bond and regulates MITOSIS, possibly by attenuating the mitosis-promoting activity of NIMA-RELATED KINASE 1.


Organisation for Economic Co-Operation and Development

Organization for Economic Cooperation and Development

An international organization whose mission is to stimulate world trade and economic progress by offering a forum where governments can collectively develop and refine social and economic policies.


The species Orcinus orca, in the family Delphinidae, characterized by its black and white coloration, and huge triangular dorsal fin. It is the largest member of the DOLPHINS and derives its name from the fact that it is a fearsome predator.


Bullous Type of Ichthyosis
Ichthyosis Bullosa of Siemens
Ichthyosis, Bullous Type of Siemens
Ichthyosis, Bullous Type

An autosomal dominant form of ichthyosis characterized by generalized reddening of the skin (ERYTHEMA) and widespread blistering. The disease shows similar, but somewhat milder, clinical and histopathological findings to those in HYPERKERATOSIS, EPIDERMOLYTIC and is associated with the gene that encodes KERATIN-2A.


Metabolically Healthy Obesity
Metabolically Benign Obesity
Obesity, Metabolically Benign

A sub-PHENOTYPE of obese individuals who have a risk for CARDIOVASCULAR DISEASES between that of healthy individuals with normal weight and unhealthy individuals with obesity.


Placenta Diseases
Placental Diseases
Placenta Disorders

Pathological processes or abnormal functions of the PLACENTA.


Postpartum Women
Postpartum Period
Puerperium
Postpartum

A period after PARTURITION, from the time of giving BIRTH to the complete involution of the UTERUS to its pre-pregnant state. Puerperium generally lasts about six to eight weeks.


An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)


A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.


Ductal, Lobular, and Medullary Neoplasms

Neoplasms, Ductal, Lobular, and Medullary

Neoplasms, usually carcinoma, located within the center of an organ or within small lobes, and in the case of the breast, intraductally. The emphasis of the name is on the location of the neoplastic tissue rather than on its histological type. Most cancers of this type are located in the breast.


Paired Box 5 Protein
B-Cell-Specific Activator Protein
B Cell-Specific Transcription Factor
Pax5A Transcription Factor
Transcription Factor PAX5
PAX5 Transcription Factor
Early B Cell-Specific Binding Protein-1

Pax5A transcription factor is the major isoform of B-cell-specific activator protein.


Recombinant 1-165 Erythropoietin, Glycoform Alpha

A recombinant glycosylated form of erythropoietin which stimulates the differentiation and proliferation of erythroid precursors. It is used for the treatment of ANEMIA associated with CHRONIC RENAL FAILURE in dialysis and predialysis patients.


Infections, Mononegavirales
Mononegavirales Infections

Infections with viruses of the order MONONEGAVIRALES. The concept includes FILOVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; and RHABDOVIRIDAE INFECTIONS.


Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.


A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.


A plant species of the family Ephedraceae, order Ephedrales, class Gnetopsida, division Gnetophyta. It is a source of EPHEDRINE and other alkaloids.


Lamina VIII
Cornu Anterius
Lamina IX
Spinal Cord Anterior Horn
Spinal Cord Ventral Horn
Cervical Spinal Cord Ventral Horn

One of three central columns of the spinal cord. It is composed of GRAY MATTER spinal laminae VIII and IX.


An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)


Carcinomatosis
Carcinoma, Spindle-Cell
Epithelial Neoplasms, Malignant
Epithelial Tumors, Malignant
Carcinoma
Carcinoma, Undifferentiated
Malignant Epithelial Neoplasms
Epithelioma
Neoplasms, Malignant Epithelial
Carcinoma, Anaplastic

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer."


Salmonella typhi Infection
Typhus, Abdominal
Enteric Fever
Typhoid
Typhoid Fever

An acute systemic febrile infection caused by SALMONELLA TYPHI, a serotype of SALMONELLA ENTERICA.


Thyroid Stimulating Hormone, beta Subunit

The beta subunit of thyroid stimulating hormone, thyrotropin. It is a 112-amino acid glycopolypeptide of about 16 kD. Full biological activity of TSH requires the non-covalently bound heterodimers of an alpha and a beta subunit.


Epidemiology, Pharmaceutical
Pharmacoepidemiology
Pharmaceutical Epidemiology

The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))


Hypercholesteremia
High Cholesterol Levels
Hypercholesterolemia
Elevated Cholesterol

A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.


Artificial Sweeteners
Sugar Substitutes
Sweetening Agents
Sweeteners

Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)


Rabies Human Diploid Cell Vaccine
Rabies Vaccines
Rabies Vaccine

Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.


Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically.


The hollow, muscular organ that maintains the circulation of the blood.


Doubly unsaturated pregnane derivatives with two hydroxy groups substituted anywhere on the rings or side chains.


Salivary Gland Calculi
Salivary Gland Stones
Sialoliths
Sialolithiasis

Calculi occurring in a salivary gland. Most salivary gland calculi occur in the submandibular gland, but can also occur in the parotid gland and in the sublingual and minor salivary glands.


Paraoxon
Fosfakol
Diethyl-p-Nitrophenyl Phosphate
E-600
Phosphacol

An organophosphate cholinesterase inhibitor that is used as a pesticide.


Breast Prosthesis Implantation
Breast Implantation

Surgical insertion of an inert sac filled with silicone or other material to augment the female form cosmetically.


Metalloexopeptidase Metalloexoproteinase Metalloexoproteinases Metalloexopeptidases

EXOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.


Anti-CD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral T-cell depletion and modulation of the T-cell receptor complex (CD3/Ti).


Patterson-Brown-Kelly Syndrome
Patterson-Kelly Syndrome
Plummer-Vinson Syndrome
Patterson's Syndrome
Syndrome, Plummer-Vinson
Kelly's Syndrome

A syndrome of DYSPHAGIA with IRON-DEFICIENCY ANEMIA that is due to congenital anomalies in the ESOPHAGUS (such as cervical esophageal webs). It is known as Patterson-Kelly syndrome in the United Kingdom.


CD11c Antigen
Antigens, CD11c
Integrin alphaX
CD11c Antigens
Leu-M5 Antigens

An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.


2',3'-Dideoxynucleosides Dideoxynucleosides Dideoxyribonucleosides ddNus

Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.


A sulfhydryl reagent that is widely used in experimental biochemical studies.


Abnormalities, Musculoskeletal
Musculoskeletal Abnormalities

Congenital structural abnormalities and deformities of the musculoskeletal system.


Health Insurance
Insurance, Health
Health Insurance, Voluntary
Group Health Insurance

Insurance providing coverage of medical, surgical, or hospital care in general or for which there is no specific heading.


Aids, Pharmaceutic
Aids, Pharmaceutical
Pharmaceutical Aids
Pharmaceutic Aids

Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.


Fire Fighters
Firefighters
Fire and Rescue Personnel

Professional or volunteer members of a fire department who are trained to suppress fire and respond to related emergency.


Organizations, Consumer
Consumer Organizations

Organized groups of users of goods and services.


Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.


Iatrogenic Disease
Hospital-Acquired Condition

Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.


Therapy, Anti-Rejection
Antirejection Therapy
Immunosuppression
Therapy, Antirejection
Anti-Rejection Therapy

Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.


Dental Amalgams
Dental Amalgam
Amalgams, Dental
Amalgam, Dental

An alloy used in restorative dentistry that contains mercury, silver, tin, copper, and possibly zinc.


Sialyl Stage-Specific Embryonic Antigen-1

A sialylated version of Lewis X antigen expressed on cell surfaces. It is a ligand for SELECTINS.


Extraction, Obstetrical
Extraction, Obstetric

Extraction of the fetus by means of obstetrical instruments.


Found in large amounts in the plasma and urine of patients with malignant melanoma. It is therefore used in the diagnosis of melanoma and for the detection of postoperative metastases. Cysteinyldopa is believed to be formed by the rapid enzymatic hydrolysis of 5-S-glutathionedopa found in melanin-producing cells.


Signs and Location Directories
Location Directories
Location Directories and Signs
Location Signs

Directory signs or listings of designated areas within or without a facility.


Infections, Chlamydia
Chlamydia Infections

Infections with bacteria of the genus CHLAMYDIA.


An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.


Acidic water usually pH 2.5 to 4.5, which poisons the ecosystem and adversely affects plants, fishes, and mammals. It is caused by industrial pollutants, mainly sulfur oxides and nitrogen oxides, emitted into the atmosphere and returning to earth in the form of acidic rain water.


HMO
Prepaid Group Health Organizations
Health Maintenance Organization
Group Health Organizations, Prepaid
Organizations, Health Maintenance
Health Maintenance Organizations

Organized systems for providing comprehensive prepaid health care that have five basic attributes: (1) provide care in a defined geographic area; (2) provide or ensure delivery of an agreed-upon set of basic and supplemental health maintenance and treatment services; (3) provide care to a voluntarily enrolled group of persons; (4) require their enrollees to use the services of designated providers; and (5) receive reimbursement through a predetermined, fixed, periodic prepayment made by the enrollee without regard to the degree of services provided. (From Facts on File Dictionary of Health Care Management, 1988)


ARHB GTP-Binding Protein
rhoB Protein
ARHB Protein
arh6 Protein
arh6 GTP-Binding Protein
rhoB GTP-Binding Protein
rhoB p20 Protein

A GTP-BINDING PROTEIN involved in regulating a signal transduction pathway that controls assembly of focal adhesions and actin stress fibers. This enzyme was formerly listed as EC 3.6.1.47.


Hexametapol
HMPA
Hexamethylphosphoramide
Hexamethylphosphoric Triamide
Hempa

A chemosterilant agent that is anticipated to be a carcinogen.


Glue Proteins, Drosophila
Glue Protein, Drosophila
Drosophila Glue Proteins

Glycosylated proteins which are part of the salivary glue that Drosophila larvae secrete as a means of fixing themselves to an external substrate for the duration of the pre-pupal and pupal period.


Guanosine Diphosphate Fucose
GDP Fucose
Guanosine Diphosphofucose

A nucleoside diphosphate sugar formed from GDPmannose, which provides fucose for lipopolysaccharides of bacterial cell walls, and for blood group substances and other glycoproteins.


Acquired Form of Epidermolysis Bullosa
Epidermolysis Bullosa, Acquired
Epidermolysis Bullosa Acquisita

Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.


Polymerase I Complex Transcription Factors

Pol1 Transcription Initiation Complex Proteins

Pol I Transcription Initiation Complex Proteins

Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.


Diol Dehydrase
Propanediol Dehydratase
Diol Dehydratase

An enzyme that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. EC 4.2.1.28.


Leu-1 Antigen
CD5 Antigen
CD5 Antigens
Antigens, CD5
T1 Antigen

Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)


AMA - American Medical Association
American Medical Association

Professional society representing the field of medicine.


Carbohydrate Dehydrogenases
Carbohydrate Oxidoreductases

Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.


Dental Impression Technic
Impression Techniques, Dental
Impression Technic, Dental
Techniques, Dental Impression
Technic, Dental Impression
Impression Technique, Dental
Technics, Dental Impression
Dental Impression Technique
Dental Impression Techniques
Technique, Dental Impression
Impression Technics, Dental
Dental Impression Technics

Procedure of producing an imprint or negative likeness of the teeth and/or edentulous areas. Impressions are made in plastic material which becomes hardened or set while in contact with the tissue. They are later filled with plaster of Paris or artificial stone to produce a facsimile of the oral structures present. Impressions may be made of a full complement of teeth, of areas where some teeth have been removed, or in a mouth from which all teeth have been extracted. (Illustrated Dictionary of Dentistry, 1982)


An agricultural fungicide and seed treatment agent.


GBetaL Protein
mTOR Associated Protein, LST8 Homolog
G protein beta Subunit-like Polypeptide
mLST8 Protein

An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and mTORC2 COMPLEX. It interacts directly with mTOR to enhance its kinase activity and stabilizes the mTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of mTOR activity.


Antipruritic Drugs
Antipruritic Agents
Antipruritics

Agents, usually topical, that relieve itching (pruritus).


A plant genus of the family TILIACEAE. Members contain lupeol and betulin TRITERPENES.


RNF71 Protein
TRIM19 Protein
Promyelocytic Leukemia Protein

A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.


Community, Therapeutic
Therapeutic Community

Psychotherapeutic technique which emphasizes socioenvironmental and interpersonal influences in the resocialization and rehabilitation of the patient. The setting is usually a hospital unit or ward in which professional and nonprofessional staff interact with the patients.


Intractable Epilepsy
Drug Refractory Epilepsy
Epilepsy, Intractable
Epilepsy, Drug Refractory
Drug Resistant Epilepsy
Medication Resistant Epilepsy
Epilepsy, Drug Resistant
Refractory Epilepsy

Epileptic condition in which adequate trials of two tolerated and appropriately chosen and used ANTIEPILEPTIC DRUGS schedules to achieve sustained seizure freedom failed.


High Molecular Weight Salivary Mucin MG1

A gel-forming mucin that is predominantly expressed by submucosal glands of airway tissues and the SUBLINGUAL GLAND. It is one of the principal components of high molecular weight salivary mucin.


Mutagenicity Tests
Toxicity Tests, Genetic
Genotoxicity Tests
Genetic Toxicity Tests
Mutagen Screening
Tests, Genetic Toxicity

Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.


PDZ Interaction Domains
PDZ Domains
PSD95-DLG-ZO1 Domains
GLGF Repeats Domains
DLG Homology Repeats Domains
DHR Domains

Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.


Cholecystitis, Emphysematous
Emphysematous Cholecystitis

A variant of acute cholecystitis with inflammation of the GALLBLADDER that is characterized by the pockets of gas in the gallbladder wall. It is due to secondary infection caused by gas-forming organisms, and has a high risk of perforation.


Test to determine the presence of blood infection (e.g. SEPSIS; BACTEREMIA).


Colorectal Cancer, Hereditary Nonpolyposis, Type 2

Colon Cancer, Familial Nonpolyposis, Type 2

Hereditary nonpolyposis colorectal neoplasms associated with other malignancies, more commonly of ovarian or uterine origin. When also associated with SEBACEOUS GLAND NEOPLASMS, it is called MUIR-TORRE SYNDROME.


A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.


Mouse, SENCAR
Mice, Inbred SENCAR
Mouse, Inbred SENCAR
Mice, SENCAR

Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.


Local Anesthesia
Neural Therapy of Huneke
Anesthesia, Infiltration
Anesthesia, Local

An ALTERNATIVE MEDICINE concept that local injection of anesthetics can interrupt symptoms in other, distant body locations.


Cystostomy
Suprapubic Cystostomy
Vesicostomy

Surgical creation of an opening (stoma) in the URINARY BLADDER for drainage.


A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices.


Methanes substituted with three halogen atoms, which may be the same or different.


A plant genus of the family ASTERACEAE that contains phenyl propanoids.


Esophago-Pharyngeal Diverticula
Zenker's Diverticulum
Pharyngoesophageal Diverticulum
Pharyngeal Diverticula
Pharyngoesophageal Diverticula
Pharyngoesophageal Pulsion Diverticula
Esophagopharyngeal Diverticulum
Pharyngoesophageal Pulsion Diverticulum
Pharyngo-Esophageal Diverticulum
Zenker Diverticulum
Zenker's Diverticula
Esophago-Pharyngeal Diverticulum
Pharyngo-Esophageal Diverticula
Pharyngeal Diverticulum

A DIVERTICULUM at the upper end of the ESOPHAGUS through the cricopharyngeal muscle at the junction of the PHARYNX and the esophagus.


Carcinoma 256, Walker
Carcinosarcoma 256, Walker

A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)


IGF-1
IGF-I
IGF-I-SmC
Insulin-Like Growth Factor I
Somatomedin C
Insulin-Like Somatomedin Peptide I
Insulin Like Growth Factor I

A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.


Adultery
Extramarital Relations
Extramarital Sex Behavior

Voluntary SEXUAL INTERCOURSE between a married person and someone other than the SPOUSE.


Tissue Preservation Solutions
Organ Preservation Solutions
Solutions, Organ Preservation

Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.


Mitogen-Activated Protein Kinase Phosphatase 3

A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CYTOSOL.


4-Trimethylaminobutyrate, 2-Oxoglutarate Oxygen Oxidoreductase (3-Hydroxylating)

An enzyme that catalyzes the HYDROXYLATION of gamma-butyrobetaine to L-CARNITINE. It is the last enzyme in the biosynthetic pathway of L-CARNITINE and is dependent on alpha-ketoglutarate; IRON; ASCORBIC ACID; and OXYGEN.


Cochliobolus Ascomycota Sclerotinia Ascomycetes

A phylum of fungi which have cross-walls or septa in the mycelium. The perfect state is characterized by the formation of a saclike cell (ascus) containing ascospores. Most pathogenic fungi with a known perfect state belong to this phylum.


Phenylmethylsulfonyl Fluoride
Phenylmethanesulfonyl Fluoride
Benzenemethanesulfonyl Fluoride

An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.


An abnormal lipoprotein present in large amounts in patients with obstructive liver diseases such as INTRAHEPATIC CHOLESTASIS. LP-X derives from the reflux of BILE lipoproteins into the bloodstream. LP-X is a low-density lipoprotein rich in free CHOLESTEROL and PHOSPHOLIPIDS but poor in TRIGLYCERIDES; CHOLESTEROL ESTERS; and protein.


Cytophagocytosis
Cytophagy
Cell Phagocytosis
Cell Cannibalism

The engulfment and degradation of cells by other cells.


Isocitrate Hydro-Lyase
Aconitase
Aconitate Hydratase
Citrate Hydro-Lyase
Citrate Hydrolyase

An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2.1.3.


Hair Colorants
Dyes, Hair
Coloring Agents, Hair
Hair Dyes

Dyes used as cosmetics to change hair color either permanently or temporarily.


The functional hereditary units of INSECTS.


Nitric Oxide Synthase
NO Synthase
Nitric-Oxide Synthetase
Nitric-Oxide Synthase

An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.


Satellite Cells, Perineuronal
Perineuronal Satellite Cells

The non-neuronal cells that surround the neuronal cell bodies of the GANGLIA. They are distinguished from the perineuronal satellite oligodendrocytes (OLIGODENDROGLIA) found in the central nervous system.


RNA Splicing
Splicing, RNA
RNA, Messenger, Splicing

The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.


Intratympanic Injection
Transtympanic Administration
Injection, Intratympanic

The administration of  liquid substances into the TYMPANIC CAVITY with a hypodermic syringe.


Molecular Farming
Molecular Pharming
Pharming

The large scale production of pharmaceutically important and commercially valuable RECOMBINANT PROTEINS.


Marek Disease-like Viruses
Marek's Disease-like Viruses
Mardivirus

A genus in the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, associated with malignancy in birds.


DNA, Single-Stranded
Single-Stranded DNA

A single chain of deoxyribonucleotides that occurs in some bacteria and viruses. It usually exists as a covalently closed circle.


A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)


gamma-L-Glu-L-Cys-Gly
Reduced Glutathione
gamma-L-Glutamyl-L-Cysteinylglycine
Glutathione

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.


Glutamyl-tRNA Synthetase
Glutamyl T RNA Synthetase
Glutamate-tRNA Ligase
Glu-tRNA Ligase

An enzyme that activates glutamic acid with its specific transfer RNA. EC 6.1.1.17.


Carbohydrate Isomerases
Carbohydrate Epimerases

Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.


Amino Acid Repeat Sequence
Amino Acid Repetitive Seq
Repetitive Sequences, Amino Acid

A sequential pattern of amino acids occurring more than once in the same protein sequence. There often is some sequence variation between the repeated segments. Many PROTEIN DOMAINS are constituted from repeats.


Pediamycin
Wyamycin E
Eyrthromycin Ethyl Succinate
Erythromycin Ethylsuccinate
Monomycin
E-Mycin E
Erythroped
EryPed

A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.


A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.


Movement Sensation
Kinesthetic Sense
Kinesthesia
Kinesthesis

Sense of movement of a part of the body, such as movement of fingers, elbows, knees, limbs, or weights.


Birdshot Retinochoroiditis
Birdshot Chorioretinopathy
Birdshot Retinochoroidopathy
Birdshot Chorioretinitis

A form of chorioretinitis characterized by multiple small, cream-colored LESIONS, symmetrically scattered mainly around the OPTIC DISK. These lesions are the most distinctive sign and often appear at the level of the RETINAL PIGMENT EPITHELIUM but, on occasion, suggest an even deeper infiltration and may ultimately lead to visual loss. An association with HLA-A29 antigen (see HLA-A ANTIGENS) has been observed in nearly all patients.


Soft Tissue Infections
Infections, Soft Tissue

Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)


Activin Receptor-like Kinase
Activin Receptor
Receptor, Activin
Activin Receptor-Like Kinases
Activin Receptors

Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.


A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.


Carcinoma, Signet Ring Cell
Signet Ring Cell Carcinoma

A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.


Ethanolamine Phosphoglycerides
Phosphatidylethanolamines
Cephalins
Ethanolamineglycerophospholipids

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.


Parathyroid Hormone Like Tumor Factor
Parathyroid Hormone-Related Peptide
PTH-Related Peptide
PTH-Like Protein
PTH Like Tumor Factor
PTHrP
Hypercalcemic Hormone of Malignancy
Tumor Hypercalcemic Factor
Parathyroid Hormone-Like Protein
Parathyroid Hormone-Related Protein

A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.


Carbapen
Microcillin
Carbenicillin
Pyopen
Carbecin
Carboxybenzyl Penicillin
Carbenicillin Disodium
Geopen
Anabactyl

Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.


Sphenoidal Sinusitis
Sinusitis, Sphenoid
Sphenoid Sinusitis

Inflammation of the NASAL MUCOSA in the SPHENOID SINUS. Isolated sphenoid sinusitis is uncommon. It usually occurs in conjunction with other paranasal sinusitis.


DNA, Satellite
Satellite DNA
Satellite I DNA

Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.


Protein Tyrosine Phosphatase, Non-Receptor Type 22

Tyrosine Protein Phosphatase, Non-Receptor Type 22

An alternatively spliced variant of tyrosine protein phosphatase, non-receptor type 22.


Livedo Reticularis And Cerebrovascular Accidents

Livedo Reticularis, Systemic Involvement

A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of livedo reticularis, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60)


Enzymes that remove UBIQUITIN from a protein substrate, including POLYUBIQUITIN, or from other molecules.


Leptospira interrogans serovar canicola
Leptospira canicola

A serovar of the bacterial species LEPTOSPIRA INTERROGANS, whose natural host is DOGS. The disease is characterized by GASTROENTERITIS, and INTERSTITIAL NEPHRITIS.


Compounds based on benzeneacetamide, that are similar in structure to ACETANILIDES.


Adhesin, Escherichia coli
Escherichia coli Adhesins
Adhesins, Escherichia coli
Adhesin, E coli

Thin, filamentous protein structures, including proteinaceous capsular antigens (fimbrial antigens), that mediate adhesion of E. coli to surfaces and play a role in pathogenesis. They have a high affinity for various epithelial cells.


Amino Acids, Phosphorus
Phosphoamino Acids

Amino acids that contain phosphorus as an integral part of the molecule.


The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.


Chemokine (C-X-C Motif) Ligand 5 Protein

Endothelial Neutrophil-Activating Peptide 78

A CXC chemokine that is predominantly expressed in EPITHELIAL CELLS. It has specificity for the CXCR2 RECEPTORS and is involved in the recruitment and activation of NEUTROPHILS.


Diagnostic Technique, Urological
Urological Diagnostic Technique
Technic, Urological Diagnostic
Diagnostic Techniques, Urological
Diagnostic Technic, Urological
Technique, Urological Diagnostic
Urological Diagnostic Techniques
Techniques, Urological Diagnostic
Diagnostic Technics, Urological
Diagnostic Technics, Urologic
Diagnostic Techniques, Urologic
Urological Diagnostic Technics
Technics, Urological Diagnostic
Urological Diagnostic Technic

Methods and procedures for the diagnosis of diseases or dysfunction of the urinary tract or its organs or demonstration of its physiological processes.


A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)


T2 Toxin
T-2 Toxin, alpha,4 beta-Isomer
Fusariotoxin
T-2 Toxin
Fusaritoxin

A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.


Transcatheter Aortic Valve Replacement
Transcatheter Aortic Valve Implantation

Surgical treatment for severe AORTIC VALVE STENOSIS. Transcatheter aortic valve replacement (TAVR) is used as an alternative option in patients who are deemed at high risk or inoperable for traditional open-heart surgery.


Gestational Hypertension
Pregnancy Induced Hypertension
Hypertension, Pregnancy-Induced
Transient Hypertension, Pregnancy

HYPERTENSION that develops as a result of PREGNANCY and regresses post partum. It is hypertension without PROTEINURIA or pathological EDEMA.


Cares, Hospital-Based Home
Home Care, Hospital-Based
Hospital Home Care Services
Hospital-Based Home Care Services
Hospital-Based Home Care
Hospital Based Home Cares
Home Care Services, Hospital Based
Home Care Services, Hospital-Based
Care, Hospital-Based Home
Home Cares, Hospital-Based

Hospital-sponsored provision of health services, such as nursing, therapy, and health-related homemaker or social services, in the patient's home. (Hospital Administration Terminology, 2d ed)


A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)


Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.


Receptors, Chemokine
Chemokine Receptors

Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.


Adrenergic beta-Antagonists
beta-Adrenoceptor Antagonists
beta-Adrenergic Antagonists
Adrenergic beta-Receptor Blockaders
beta-Adrenergic Receptor Blockaders
beta-Blockers, Adrenergic
beta-Adrenergic Blockers
beta-Adrenergic Blocking Agents

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.


1,2,4,5-Tetraoxanes Tetraoxanes Tetra-Oxanes Tetroxanes

Compounds with two peroxide groups, that is, two pairs of adjacent OXYGEN atoms. They may have activity against PLASMODIUM similar to the ARTEMISININS.


A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.


Aqueductal Stenosis
Hydrocephalus
Congenital Hydrocephalus
Fetal Cerebral Ventriculomegaly
Cerebral Ventriculomegaly
Communicating Hydrocephalus
Post-Traumatic Hydrocephalus
Hydrocephalus Ex-Vacuo
Hydrocephaly
Obstructive Hydrocephalus

Enlargement of CEREBRAL VENTRICLES. Although it is often isolated without other CNS anomalies it can be associated with other congenital malformations (e.g., ARNOLD-CHIARI MALFORMATION; DANDY-WALKER MALFORMATION, and ACROCALLOSAL SYNDROME).


Cryptochrome Proteins
Cryptochromes
Cryptochrome

Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.


Asymptomatic Multiple Myeloma
Smoldering Myeloma
Smoldering Multiple Myeloma

An asymptomatic and slow-growing PLASMA CELL dyscrasia characterized by presence of MYELOMA PROTEINS and clonal bone marrow plasma cells without end-organ damage (e.g., renal impairment). It is distinguished from MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE by a much higher risk of progression to symptomatic MULTIPLE MYELOMA.


IL13Ralpha2
Interleukin-13 Receptor alpha2 Subunit
Antigens, CD213a2
Interleukin-13 Decoy Receptor
Interleukin-13 Receptor alpha2
Receptor, Interleukin-13 alpha2
Interleukin-13 Receptor alpha2 Chain
IL-13 Receptor alpha2
CD213a2 Antigens
CD213a2 Antigen

An interleukin-13 receptor subunit that is closely-related to the INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT. The receptor is found as a monomeric protein and has been considered to be a decoy receptor for interleukin-13 due the fact that it lacks cytoplasmic signaling domains.


Vasopeptidase Inhibitors
ACE-NEP Inhibitors
NEP-ACE Inhibitors

A class of cardiovascular drugs indicated for hypertension and congestive heart failure that simultaneously inhibit both NEUTRAL ENDOPEPTIDASE and ANGIOTENSIN CONVERTING ENZYME. They increase the availability of NATRIURETIC PEPTIDES and BRADYKININ and inhibit production of ANGIOTENSIN II.


The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.


Phosphorylcholine, Acetyl Glyceryl Ether

A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.


Regenerating Islet-Derived 1 beta Protein

Regenerating Islet-Derived 1 alpha Protein

The proteinaceous component of the pancreatic stone in patients with PANCREATITIS.


Biocisplatinum
cis-Dichlorodiammineplatinum(II)
Platinum Diamminodichloride
cis-Platinum
Platinol
Platino
NSC-119875
Platidiam
cis-Diamminedichloroplatinum
Dichlorodiammineplatinum
Cisplatin
cis-Diamminedichloroplatinum(II)

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.


Animal Nutritional Physiology Phenomenon

Animal Nutritional Physiological Phenomena

Animal Nutritional Physiological Phenomenon


Measure of the number of the PARASITES present in a host organism.


HuR Paraneoplastic Encephalomyelitis Antigen

An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.


Helix-Turn-Helix, ETS-Type Domain Containing

A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.


CSF Receptors
Receptors, Colony-Stimulating Factor
Colony-Stimulating Factor Receptor
Hematopoietic Growth Factors Receptors
Receptors, Hematopoietic Growth Factors
Hematopoietic Growth Factor Receptor
Colony-Stimulating Factor Receptors

Cell surface receptors for colony stimulating factors, local mediators, and hormones that regulate the survival, proliferation, and differentiation of hemopoietic cells.


Condition wherein the force of gravity is less than or is decreased below that on the surface of the earth. This is expressed as being between 0 and 1 g.


Leukocytes, Mononuclear
Mononuclear Leukocytes

Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.


Ethoxazolamide Ethamide Ethoxyzolamide Ethoxzolamide

A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.


Phospholipid Hydroperoxide Glutathione Peroxidase GPX4

GPX4 Phospholipid Hydroperoxide Glutathione Peroxidase

Selenium-Dependent Glutathione Peroxidase Type-4

A selenoenzyme that converts GLUTATHIONE plus FATTY ACID HYDROPEROXIDES to GLUTATHIONE DISULFIDE plus hydroxy fatty acids and water.


Guanase
Guanine Aminohydrolase
Guanine Deaminase
Guanine Aminase

An enzyme that catalyzes the deamination of guanine to form xanthine. EC 3.5.4.3.


Pseudosugars Carbasugars Carba-Sugars Carba-Monosaccharides

Sugar analogs in which the ring oxygen is replaced by a methylene (CH2) carbon.


Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).


Herpes Virus B
Herpesvirus Simiae
Herpes B Virus
Herpesvirus B
Macacine Herpesvirus 1
Herpesvirus 1, Cercopithecine
Herpesvirus 1 (alpha), Cercopithecine
B Virus
Simian Herpesvirus
Macacine alphaherpesvirus 1
Cercopithecine Herpesvirus 1
Monkey B Virus

A species of SIMPLEXVIRUS that causes vesicular lesions of the mouth in monkeys. When the virus is transmitted to man it causes an acute encephalitis or encephalomyelitis, which is nearly always fatal.


Influenza A Virus, H1N1 Subtype
Swine-Origin Influenza A H1N1 Virus
H1N1 Virus

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.


A single protein comprised of tandem repeats of the UBIQUITIN 78-amino acid sequence. It is a product of the polyubiquitin gene which contains multiple copies of the ubiquitin coding sequence. Proteolytic processing of ubiquitin C results in the formation of individual ubiquitin molecules. This protein is distinct from POLYUBIQUITIN, which is a protein formed through isopeptide linkage of multiple ubiquitin species.


Receptors, Cholinergic
Receptors, ACh
ACh Receptors
Cholinoceptive Sites
Cholinergic Receptors
Acetylcholine Receptors
Receptors, Acetylcholine
Cholinoceptors

Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.


Diacetyl Reductase ((R)-Acetoin Forming)

Diacetyl Reductase ((S)-Acetoin Forming)

An enzyme that catalyzes the conversion of acetoin to diacetyl in the presence of NAD.


APOE-epsilon2
ApoE2
Apo E2
Apolipoprotein E-epsilon2
Apolipoprotein E2
Apolipoprotein E-2
APOE-epsilon 2
Apo E-2

One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.


Cell surface receptors that bind thyrotropin releasing hormone (TRH) with high affinity and trigger intracellular changes which influence the behavior of cells. Activated TRH receptors in the anterior pituitary stimulate the release of thyrotropin (thyroid stimulating hormone, TSH); TRH receptors on neurons mediate neurotransmission by TRH.


Psoriasis, Arthritic
Arthritis, Psoriatic
Psoriatic Arthropathy
Psoriasis Arthropathica
Psoriatic Arthritis

A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.


gag Polyproteins
gag Gene Related Protein
gag Gene Products
gag Viral Proteins
Viral gag Proteins
Gene Product, gag
Retroviral Antigen gag Protein
gag Polyprotein
Gene Products, gag
gag Antigens
gag Protein

Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.


Tooth Extrusion
Orthodontic Extrusion
Forced Eruption

Orthodontic movement in the coronal direction achieved by outward tension on the PERIODONTAL LIGAMENT. It does not include the operative procedure that CROWN LENGTHENING involves.


U1 Small Nuclear Ribonucleoproteins
Small Nuclear Ribonucleoproteins, U1
Ribonucleoproteins, Small, U1
U1 snRNP
Ribonucleoprotein, U1 Small Nuclear

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.


Hepatocyte Nuclear Factor 1
HNF-1 Protein
Hepatic Nuclear Factor 1
HNF1 Transcription Factor

A transcription factor and homeodomain protein that regulates the expression of a large set of hepatic proteins including SERUM ALBUMIN; beta-fibrinogen; and ALPHA 1-ANTITRYPSIN. It is composed of hetero- or homo-dimers of HEPATOCYTE NUCLEAR FACTOR 1-ALPHA and HEPATOCYTE NUCLEAR FACTOR 1-BETA.


Seven membered heterocyclic rings containing a NITROGEN atom.


Growth Hormone Insensitivity Syndrome
Laron Type Dwarfism I
Growth Hormone Receptor Defect
Laron Syndrome
Laron Dwarfism
Growth Hormone Receptor Deficiency
Pituitary Dwarfism II
Primary Growth Hormone Resistance
Primary GH Resistance
Severe GH Insensitivity

An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.


Leptospira interrogans serovar pomona
Leptospira pomona

A serovar of the bacterial species LEPTOSPIRA INTERROGANS, whose primary hosts include CATTLE and SWINE.


P3a Event-Related Potentials
Evoked Potentials, P300 Component
Event-Related Potentials, P300
P300 Component
P300 Event-Related Potentials
Event-Related Potentials, P3
P3 Event-Related Potentials
P3b Event-Related Potentials

A late-appearing component of the event-related potential. P300 stands for a positive deflection in the event-related voltage potential at 300 millisecond poststimulus. Its amplitude increases with unpredictable, unlikely, or highly significant stimuli and thereby constitutes an index of mental activity. (From Campbell, Psychiatric Dictionary, 6th ed)


WHO regional office for the Americas acting as a coordinating agency for the improvement of health conditions in the hemisphere. The four main functions are: control or eradication of communicable diseases, strengthening of national and local health services, education and training, and research.


CRPPP
Mg CTP
CTP
Cytidine Triphosphate
Magnesium CTP

Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.


beta-Fructosidase
Saccharase
beta-Fructofuranosidase
Acid Invertase
beta-D-Fructofuranosidase
Sucraid
Sucrose 6-Phosphate Hydrolase
Sacrosidase
Invertase

A glycoside hydrolase found primarily in PLANTS and YEASTS. It has specificity for beta-D-fructofuranosides such as SUCROSE.


Minor Histocompatibility Antigens
Minor Histocompatibility Peptides
Histocompatibility Antigens, Minor

Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.


Chronic Brain Injury
Brain Injury, Chronic

Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from DIFFUSE AXONAL INJURY; INTRACRANIAL HEMORRHAGES; BRAIN EDEMA; and other conditions. Clinical features may include DEMENTIA; focal neurologic deficits; PERSISTENT VEGETATIVE STATE; AKINETIC MUTISM; or COMA.


Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of FLUORIDE compounds.


Oxalacetic Acid
2-Ketosuccinic Acid
Oxaloacetate
Oxaloacetic Acid
2-oxo-Butanedioic Acid
Ketosuccinic Acid


A genus of hard-shelled clams in the family Veneridae, class BIVALVIA, commonly called quahogs. They are found just below the surface in the subtidal or lower intertidal coastal waters.


A mature haploid female germ cell extruded from the OVARY at OVULATION.


The enhancement of physical, cognitive, emotional and social skills so an individual may participate in chosen activities. Recreational modalities are used in designed intervention strategies, incorporating individual's interests to make the therapy process meaningful and relevant.


Real World Clinical Trials
Pragmatic Clinical Trials
Practical Clinical Trials
Pragmatic Clinical Trials as Topic
Pragmatic Trials
Naturalistic Randomized Clinical Trial

Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.


Areas of attractive or repulsive force surrounding MAGNETS.


Anti-Phospholipid Syndrome
Antiphospholipid Antibody Syndrome
Anti-Phospholipid Antibody Syndrome
Antiphospholipid Syndrome
Hughes Syndrome

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).


Autologous Transplants
Autografts
Autotransplants

Transplant comprised of an individual's own tissue, transferred from one part of the body to another.


Urinary Bladder Diseases
Bladder Diseases

Pathological processes of the URINARY BLADDER.


Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.


A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.


MafF Transcription Factor
Transcription Factor Maf

A small maf protein that forms dimers with NRF1 protein; NRF2 PROTEIN; and P45 NF-E2 PROTEIN. MafF complexes bind Maf recognition elements to regulate tissue-specific GENETIC TRANSCRIPTION.


Hematopoietic Stem Cell-Activating Factors

These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes.


White-Throated Capuchin
Cebus capucinus
Cebus capucinus imitator
C. capucinus
White-Faced Capuchin Monkeys
Colombian White-Faced Capuchin
White-Faced Capuchin

A species of the genus CEBUS, family CEBIDAE, consisting of capuchin monkeys with white markings over most of frontal areas of the face, chest and upper arms.


French Revolution
France Revolution, 1789-1799

Conflict during which traditional monarchy was ended and modern government functions were instituted.


Tyrosinase
Phenoloxidase A
Monophenol Monooxygenase
Phenoloxidase
Phenol Oxidase
Phenoloxidase B
Cresolase
Dopa Oxidase

An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.


Cervical Mucus
Palm-Leaf Reaction
Fern Test
Cervix Mucus

A slightly alkaline secretion of the endocervical glands. The consistency and amount are dependent on the physiological hormone changes in the menstrual cycle. It contains the glycoprotein mucin, amino acids, sugar, enzymes, and electrolytes, with a water content up to 90%. The mucus is a useful protection against the ascent of bacteria and sperm into the uterus. (From Dictionary of Obstetrics and Gynecology, 1988)


Eye Lens Protein
Crystallins
Lens Proteins
Crystallin

A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. The presence of these proteins accounts for the transparency of the lens. The family is composed of four major groups, alpha, beta, gamma, and delta, and several minor groups, which are classed on the basis of size, charge, immunological properties, and vertebrate source. Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses.


Technetium Tc 99m Dimercaptosuccinic Acid

A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.


A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.


CYP12 Family
Cytochrome P450 Family 12
CYP12 Enzymes

A cytochrome P450 enzyme family that occurs in insects and is expressed in MITOCHONDRIA.


A semisynthetic anthracycline with the amino sugar on the D ring. It displays broad-spectrum antineoplastic activity against a variety of tumors.


Macular Holes
Retinal Breaks
Retinal Tears
Retinal Holes
Retinal Perforations
Retinal Dialyses

Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.


Socialized Dentistry
Dentistry, Socialized
Dentistry, State
State Dentistry

Control, direction and financing of the total dental care of the population by a national government.


Diarylquinoline Derivatives
Diarylquinolines
Diaryl Quinoline Derivatives

A class of quinoline compounds defined by the presence of two aromatic ring structures which are attached via a side chain to carbon 3 of the qunolinyl structure. The two aromatic moieties are typically NAPTHALENE and BENZENE. Several compounds in this class are used as ANTITUBERCULAR AGENTS.


Anthracenediones
Anthraquinone Derivatives
Anthraquinones
Anthranoids
Anthraquinone Compounds

Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.


Incentive Plans, Employee
Employee Incentive Plans

Programs designed by management to motivate employees to work more efficiently with increased productivity, and greater employee satisfaction.


A plant genus of the family EUPHORBIACEAE that contains bukittinggine and PHORBOL ESTERS.


Sex Hormone-Binding Globulin
Testosterone-Estradiol Binding Globulin
Sex Steroid-Binding Protein

A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.


Rickettsia tsutsugamushi
Orientia tsutsugamushi

A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.


An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.


Technology, High-Cost
High-Cost Technology

Advanced technology that is costly, requires highly skilled personnel, and is unique in its particular application. Includes innovative, specialized medical/surgical procedures as well as advanced diagnostic and therapeutic equipment.


Respiratory Syncytial Virus Infection
Respiratory Syncytial Virus Infections
Infections, Respiratory Syncytial Virus

Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.


Gene Expression Regulation, Plant
Plant Gene Expression Regulation
Regulation, Gene Expression, Plant
Regulation of Gene Expression, Plant

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.


Cytoplasmic Elongation Factor 2
NSP100
Peptide Elongation Factor 2
EF-2
Elongation Factor 2
NSP 100

Peptide Elongation Factor 2 catalyzes the translocation of peptidyl-tRNA from the A site to the P site of eukaryotic ribosomes by a process linked to the hydrolysis of GTP to GDP.


Metabolic Surgery
Bariatric Surgeries
Bariatric Surgery
Bariatric Surgical Procedures
Stomach Stapling

Surgical procedures aimed at affecting metabolism and producing major WEIGHT REDUCTION in patients with MORBID OBESITY.


Hydrea Hydroxycarbamid Hydroxyurea Oncocarbide

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.


MEK2 (MAPK Extracellular Signal-Regulated Kinase 2)

Mitogen-Activated Protein Kinase Kinase 2

MEK-2 (MAPK Extracellular Signal-Regulated Kinase 2)

A 44 kDa mitogen-activated protein kinase kinase with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.


Rheography, Light Reflection
Light Reflection Rheography
Photoreflexometry
Photoplethysmography

Plethysmographic determination in which the intensity of light reflected from the skin surface and the red cells below is measured to determine the blood volume of the respective area. There are two types, transmission and reflectance.


Computing, Medical Informatics
Informatics Computing, Medical
Medical Informatics Computing

Precise procedural mathematical and logical operations utilized in the study of medical information pertaining to health care.


Compounds that include the structure of dibenzofuran.


Licensure, Nursing
Nursing Licensure
Licensures, Nursing
Nursing Licensures

The granting of a license to practice the profession of nursing.


Xanthomonas maltophilia
Stenotrophomonas maltophilia
Pseudomonas maltophilia

A species of STENOTROPHOMONAS, formerly called Xanthomonas maltophilia, which reduces nitrate. It is a cause of hospital-acquired ocular and lung infections, especially in those patients with cystic fibrosis and those who are immunosuppressed.


Herniation of the RECTUM into the VAGINA.


5,8,11,14,17-Eicosapentaenoic Acid
Eicosapentanoic Acid
Timnodonic Acid
omega-3-Eicosapentaenoic Acid
5,8,11,14,17-Icosapentaenoic Acid
Eicosapentaenoic Acid

Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.


The number of times an organism breathes with the lungs (RESPIRATION) per unit time, usually per minute.


Video-Assisted Surgery
Surgery, Video-Assisted

Endoscopic surgical procedures performed with visualization via video transmission. When real-time video is combined interactively with prior CT scans or MRI images, this is called image-guided surgery (see SURGERY, COMPUTER-ASSISTED).


Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.


Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.


Facial Nucleus
Nucleus Nervi Facialis
Nucleus Facialis
Facial Motor Nucleus

A region in the pontine tegmentum that is the nucleus of the FACIAL NERVE.


Sensory System Drugs
Sensory System Agents

Drugs that act on neuronal sensory receptors resulting in an increase, decrease, or modification of afferent nerve activity. (From Smith and Reynard, Textbook of Pharmacology, 1991, p367)


HSP110 Heat-Shock Proteins
Heat-Shock Proteins 110
110-kDa Heat Shock Protein
Heat-Shock Protein 110

A group of eukaryotic high-molecular mass heat-shock proteins that represent a subfamily of HSP70 HEAT-SHOCK PROTEINS. Hsp110 proteins prevent protein aggregation and can maintain denatured proteins in folding-competent states.


Wnt3 Proteins
Wnt-3 Protein
Wnt3 Protein

A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE. Defects in Wnt3 protein are associated with autosomal recessive tetra-AMELIA in humans.


A crystalline compound used as a laboratory reagent in place of HYDROGEN SULFIDE. It is a potent hepatocarcinogen.


Glutamylcysteine Synthetase
gamma-Glutamyl-Cysteine Synthetase
Glutamate-Cysteine Ligase

One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.


Antibodies, Helminth
Helminth Antibodies

Immunoglobulins produced in a response to HELMINTH ANTIGENS.


Radio-Frequency Ablation
Radiofrequency Ablation
Radio Frequency Ablation

Removal of tissue using heat generated from electrodes delivering an alternating electrical current in the frequency of RADIO WAVES.


Nerve Growth Cone Membrane Protein GAP-43

A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.


Posttranslational Amino Acid Modification

Amino Acid Modification, Posttranslational

Amino Acid Modification, Post-Translational

Post-Translational Amino Acid Modification

Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.


A genus of the family Lemuridae consisting of five species: L. catta (ring-tailed lemur), L. fulvus, L. macaco (acoumba or black lemur), L. mongoz (mongoose lemur), and L. variegatus (white lemur). Most members of this genus occur in forested areas on Madagascar and the Comoro Islands.


Exfoliative Toxin B
Exfoliative Toxins
Epidermolytic Toxins
Staphylococcal Exfoliative Toxin
Dermolysins
Epidermolysins
Exfoliatins
Exfoliatin Toxin A

Protein exotoxins from Staphylococcus aureus, phage type II, which cause epidermal necrolysis. They are proteins with a molecular weight of 26,000 to 32,000. They cause a condition variously called scaled skin, Lyell or Ritter syndrome, epidermal exfoliative disease, toxic epidermal necrolysis, etc.


IL-11 Receptors
Interleukin-11 Receptor
Interleukin-11 Receptors
Receptors, Interleukin-11
IL-11 Receptor
IL11 Receptor
Receptor, Interleukin-11

Cell surface receptors that are specific for INTERLEUKIN-11. They consist of heterodimers of the INTERLEUKIN-11 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130.


Integrin beta1
4B4 Antigen
beta1 Integrin
CDw29 Antigen
Antigens, CD29
CD29 Antigens
CD29 Antigen

Integrin beta chain expressed as a heterodimer that is non-covalently associated with specific alpha-chains of the CD49 family (CD49a-f). It is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)


Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.


The functional hereditary units of protozoa.


Corneoscleral Junction
Sclerocorneal Limbus
Limbus Corneae
Corneal Limbus

An annular transitional zone, approximately 1 mm wide, between the cornea and the bulbar conjunctiva and sclera. It is highly vascular and is involved in the metabolism of the cornea. It is ophthalmologically significant in that it appears on the outer surface of the eyeball as a slight furrow, marking the line between the clear cornea and the sclera. (Dictionary of Visual Science, 3d ed)


Specific substances elaborated by plants, microorganisms or animals that cause damage to the skin; they may be proteins or other specific factors or substances; constituents of spider, jellyfish or other venoms cause dermonecrosis and certain bacteria synthesize dermolytic agents.


Transfer to Adult Care
Pediatric Transition To Adult Care
Transfer from Pediatric to Adult Care
Transferring to Adult Care
Transition to Adult Care


Teaching and administrative staff having academic rank in a pharmacy school or department.


ras Homolog Family Member C
rhoC GTPase
rhoC GTP-Binding Protein

A rho GTP-binding protein that is prenylated (see PROTEIN PRENYLATION) at its C-terminus and cycles between the cytoplasm and plasma membrane, linking receptor signaling pathways with assembly of FOCAL ADHESIONS; STRESS FIBERS; and contractile ring formation during CYTOKINESIS. It is overexpressed in proliferating and metastatic tumor cells.


Thorium Dioxide
Thorium Oxide
Thorotrast

Thorium oxide (ThO2). A radiographic contrast agent that was used in the early 1930s through about 1954. High rates of mortality have been linked to its use and it has been shown to cause liver cancer.


Conjunctivitides, Bacterial
Conjunctivitis, Purulent
Bacterial Conjunctivitis
Bacterial Conjunctivitides
Conjunctivitis, Mucopurulent
Conjunctivitis, Bacterial

Purulent infections of the conjunctiva by several species of gram-negative, gram-positive, or acid-fast organisms. Some of the more commonly found genera causing conjunctival infections are Haemophilus, Streptococcus, Neisseria, and Chlamydia.


Hypertriglyceridemic Waist
Enlarged Waist Elevated Triglycerides

A screening phenotype consisting of both elevated WAIST CIRCUMFERENCE and elevated fasting TRIGLYCERIDES level.


5-Bromo-2'-deoxycytidine. Can be incorporated into DNA in the presence of DNA polymerase, replacing dCTP.


Euthanasia, Negative
Allowing to Die
Passive Euthanasia
Euthanasia, Passive
Negative Euthanasia

Failing to prevent death from natural causes, for reasons of mercy by the withdrawal or withholding of life-prolonging treatment.


A genus of Sciuridae consisting of 14 species. They are shortlegged, burrowing rodents which hibernate in winter.


Glycine Dehydrogenase (Decarboxylating)
P-protein, Glycine Decarboxylase
Glycine Cleavage System P-Protein
Glycine Decarboxylase
Glycine Decarboxylase Complex P-Protein

A PYRIDOXAL PHOSPHATE dependent enzyme that catalyzes the decarboxylation of GLYCINE with the transfer of an aminomethyl group to the LIPOIC ACID moiety of the GLYCINE DECARBOXYLASE COMPLEX H-PROTEIN. Defects in P-protein are the cause of non-ketotic hyperglycinemia. It is one of four subunits of the glycine decarboxylase complex.


Acetate ester of norethindrone that is used as a long-term contraceptive (CONTRACEPTIVE AGENTS).


Emotional Adjustment
Psychological Adjustment
Emotional Adaptation

Psychological process that occurs when an individual adapts to a significant emotional event or stimulus.


Pathology Department, Hospital
Hospital Pathology Department
Pathology Departments, Hospital
Department, Hospital Pathology

Hospital department which administers and provides pathology services.


Tumor Necrosis Factor Ligand Superfamily Member 5

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.


Proerythroblasts
Erythrocytes, Nucleated
Normoblasts
Erythroblasts
Pronormoblasts

Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.


Middle Ear Cholesteatoma
Aural Cholesteatoma
Cholesteatoma, Middle Ear

A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR.


Task Forces
Advisory Committees
Review Committees
Governmental Commissions

Committees established to monitor compliance with standards or policies.


Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.


Health Status Disparity
Health Status Disparities

Variation in rates of disease occurrence and disabilities between population groups defined by socioeconomic characteristics such as age, ethnicity, economic resources, or gender and populations identified geographically or similar measures.


Lysine-Specific tRNA
tRNALys
tRNA(Lys)
Transfer RNA, Lys
RNA, Transfer, Lys

A transfer RNA which is specific for carrying lysine to sites on the ribosomes in preparation for protein synthesis.


Behcet Disease
Triple-Symptom Complex
Behcet's Syndrome
Behcet Triple Symptom Complex
Adamantiades-Behcet Disease
Behçet Disease
Triple Symptom Complex
Behcet Syndrome
Old Silk Route Disease

Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.


A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.


This single species of Gorilla, which is a member of the HOMINIDAE family, is the largest and most powerful of the PRIMATES. It is distributed in isolated scattered populations throughout forests of equatorial Africa.


Intrapleural Analgesia
Interpleural Analgesia

Injection of ANALGESICS; LOCAL ANESTHETICS; or NARCOTICS into the PLEURAL CAVITY between the two pleural membranes.


Membrane Transport-Proteins, Organic Cation

A family of proteins involved in the transport of organic cations. They play an important role in the elimination of a variety of endogenous substances, xenobiotics, and their metabolites from the body.


Chronic Esophagitis, Eosinophilic
Esophagitis, Eosinophilic
Eosinophilic Esophagitis

Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.


Meiotic Recombination 11 Homolog 1 Protein

A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.


Hyalin Substance
Hyaline Substance
Hyaline
Hyalin

A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.


Visual Fatigue
Asthenopia
Eye Fatigue
Fatigue, Visual
Eyestrain

Term generally used to describe complaints related to refractive error, ocular muscle imbalance, including pain or aching around the eyes, burning and itchiness of the eyelids, ocular fatigue, and headaches.


Nervous System Diseases, Manganese-Induced

Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)


Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.


Cleavage Stimulation Factor
CstF Protein

A RNA-binding protein that stimulates the cleavage of the 3' end of MRNA near the POLYADENYLATION site. It is a heterotrimer of 55-, 64- and 77-kDa subunits and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.


Treatment of MUSCULOSKELETAL PAIN by injecting a substance into a joint space, ligament, or tendon to promote the growth of new tissue.


Terminals, Computer
Video Display Terminals
Computer Terminals

Input/output devices designed to receive data in an environment associated with the job to be performed, and capable of transmitting entries to, and obtaining output from, the system of which it is a part. (Computer Dictionary, 4th ed.)


Glycine Decarboxylase Complex T-Protein
Aminomethyltransferase
T-Protein, Glycine Cleavage System
Glycine Synthase
Tetrahydrofolate Aminomethyltransferase

A one-carbon group transferase that transfers lipoamide-linked methylamine groups to tetrahydrofolate (TETRAHYDROFOLATES) to form methylenetetrahydrofolate and AMMONIA. It is one of four components of the glycine decarboxylase complex.


Sodium Oxybutyrate
Somsanit
Xyrem
Oxybate Sodium
4-Hydroxybutyrate Sodium
Sodium gamma-Hydroxybutyrate
Sodium Oxybate
gamma-Hydroxybutyrate

The sodium salt of 4-hydroxybutyric acid. It is used for both induction and maintenance of ANESTHESIA.


Supplementary Medical Insurance Program, Medicare

Medicare Supplementary Medical Insurance Program

The voluntary portion of Medicare, known as the Supplementary Medical Insurance (SMI) Program, that includes physician's services, home health care, medical services, outpatient hospital services, and laboratory, pathology, and radiology services. All persons entitled to Medicare Part A may enroll in Medicare Part B on a monthly premium basis.


Passive Range of Motion
Range of Motion, Articular
Joint Flexibility
Joint Range of Motion
Range of Motion

The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.


A normal developing tooth which has not yet perforated the oral mucosa or one that fails to erupt in the normal sequence or time interval expected for the type of tooth in a given gender, age, or population group.


The larval form of the diphyllobothriid tapeworms of the genus DIPHYLLOBOTHRIUM and SPIROMETRA. Fish-eating mammals and man are the final hosts.


A plant genus of the family PTERIDACEAE. Members contain entkaurane DITERPENES. The name is similar to bracken fern (PTERIDIUM).


Chloride Channel Activators
Chloride Channel Agonists
Chloride Channel Stimulators

A class of drugs that stimulate chloride ion influx through cell membrane channels.


Sjogren Syndrome
Sicca Syndrome
Sjogren's Syndrome

Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.


Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit

Regulatory Subunit RIIbeta, Cyclic-AMP-Dependent Protein Kinase

cAMP-Dependent Protein Kinase, Type 2beta-Regulatory Subunit

Cyclic-AMP-Dependent Protein Kinase RIIbeta Subunit

A type II cAMP-dependent protein kinase regulatory subunit that plays a role in confering CYCLIC AMP activation of protein kinase activity. It has a lower affinity for cAMP than the CYCLIC-AMP-DEPENDENT PROTEIN KINASE RIIALPHA SUBUNIT. Binding of this subunit by A KINASE ANCHOR PROTEINS may play a role in the cellular localization of type II protein kinase A.


Loxosceles reclusa
Brown Violin Spider
Violin Spider
Brown Recluse Spider

A spider of the genus Loxosceles, found in the midwestern and other parts of the United States, which carries a hemolytic venom that produces local necrosis or ulceration.


Cholestasis
Bile Duct Obstruction
Biliary Stasis

Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).


Long Term Adverse Effects
Adverse Effects, Long Term

Persistent detrimental effects from treatment for a condition. Included are effects from surgery such as POSTOPERATIVE COMPLICATIONS, and from DRUG THERAPY, such as CHEMICALLY INDUCED DISORDERS, or other THERAPEUTICS. Failure to attain a desired outcome from treatment for the condition is not considered an adverse effect.


Injury, Smoke Inhalation
Inhalation Injury, Smoke
Smoke Inhalation Injury

Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.


Articulator, Dental
Articulators, Dental
Articulators
Dental Articulator
Dental Articulators

Mechanical devices that simulate the temporomandibular joints and jaws to which maxillary and mandibular casts are attached. The entire assembly attempts to reproduce the movements of the mandible and the various tooth-to-tooth relationships that accompany those movements.


Acetic Acid
Glacial Acetic Acid
Acetic Acid Glacial
Vinegar

Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)


Liver Insufficiency
Hepatic Insufficiency

Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.


Carbohydrate-Restricted Diet
Low-Carbohydrate Diet
Diet, Low Carbohydrate
Diet, Carbohydrate-Restricted

A diet that contains limited amounts of CARBOHYDRATES. This is in distinction to a regular DIET.


Hypoprothrombinemia
Prothrombin Deficiency
Factor II Deficiency
Hypoprothrombinemias
Deficiency, Factor II

Absence or reduced levels of PROTHROMBIN in the blood.


Formyltetrahydrofolate Synthetase
Formate-Tetrahydrofolate Ligase
Tetrahydrofolate Formylase

A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.


Epichlorohydrin
Epichlorohydrin, (S)-Isomer
Epichlorohydrin, (+-)-Isomer
Epichlorhydrin

A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.


Fumarate Reductase
Succinic Dehydrogenase
Succinic Oxidase
Succinate Dehydrogenase

A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.


Blue-light receptors that regulate a range of physiological responses in PLANTS. Examples include: PHOTOTROPISM, light-induced stomatal opening, and CHLOROPLAST movements in response to changes in light intensity.


A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).


Immobilization, Physical
Restraint, Physical
Physical Restraint

Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.


A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.


Skin Electric Conductance
Electrodermal Response
Galvanic Skin Response
Electric Conductance, Skin
Reflex, Psychogalvanic

A change in electrical resistance of the skin, occurring in emotion and in certain other conditions.


epsilon-Crystallins
Crystallins, epsilon
epsilon-Crystallin

A group of crystallins that have been found in the lens (LENS, CRYSTALLINE) of DUCKS and CROCODILES. They are inactivated forms of the B chain subunit of lactate dehydrogenase.


Plethysmography, Whole Body
Whole Body Plethysmography

Measurement of the volume of gas in the lungs, including that which is trapped in poorly communicating air spaces. It is of particular use in chronic obstructive pulmonary disease and emphysema. (Segen, Dictionary of Modern Medicine, 1992)


Mitochondrial Uncoupling Protein 2
Uncoupling Protein 2
UCP2 Protein
Uncoupling Protein-2
SLC25A8 Protein
Solute Carrier Family 25 Member 8

A mitochondrial uncoupling protein that is expressed in many tissues and exhibits the greatest expression in SKELETAL MUSCLE. It regulates mitochondrial ATP production and the generation of REACTIVE OXYGEN SPECIES.


Esophageal Achalasia
Megaesophagus
Cardiospasm
Achalasia
Achalasia, Esophageal

A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).


CC Chemokine Ligand 1
Chemokine TCA3
T Cell Activation 3 Protein
Chemokine I-309
Chemokines CCL1
Chemokine CCL1
CCL1 Chemokine

A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. It has specificity for CCR8 RECEPTORS.


Complementary DNA
DNA, Complementary
cDNA
cDNA Probes

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.


Open Fracture Reduction
Open Reduction, Fracture

Restoration of normal alignment of a fractured bone via an OPERATIVE SURGICAL PROCEDURE.


Juxtaglomerular Hyperplasia with Secondary Aldosteronism

Aldosteronism with Hyperplasia of the Adrenal Cortex

A group of disorders caused by defective salt reabsorption in the ascending LOOP OF HENLE. It is characterized by severe salt-wasting, HYPOKALEMIA; HYPERCALCIURIA; metabolic ALKALOSIS, and hyper-reninemic HYPERALDOSTERONISM without HYPERTENSION. There are several subtypes including ones due to mutations in the renal specific SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.


An inherited autosomal dominant trait characterized by abnormally elevated levels of total serum THYROXINE; (T4) in euthyroid patients with abnormal SERUM ALBUMIN that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and TSH are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the ALB gene on CHROMOSOME 4.


ATP Binding Cassette Transporter, Sub-Family A

ATP Binding Cassette Transporter, Subfamily A

A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.


Abortion, Recurrent
Abortion, Habitual
Recurrent Early Pregnancy Loss
Miscarriage, Recurrent

Three or more consecutive spontaneous abortions.


Abscess, Periodontal
Periodontal Abscess

Localized circumscribed purulent area of inflammation in the periodontal tissue. It is a derivative of marginal periodontitis and commonly associated with suprabony and infrabony pockets and interradicular involvements, in contrast to periapical abscess which is attributable to pulp necrosis.