Translational Medical Research
Knowledge Translation
Translational Research
Translational Medical Science
Translational Research, Medical
Translational Medicine

The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.


Solute Carrier Family 22 (Organic Anion Transporter), Member 6

A polyspecific transporter for organic cations found primarily in the kidney. It mediates the coupled exchange of alpha-ketoglutarate with organic ions such as P-AMINOHIPPURIC ACID.


Rats, WKY
Rats, Inbred WKY
Rats, Wistar Kyoto

A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).


Buprenorphine, Naloxone Drug Combination

A pharmaceutical preparation that combines buprenorphine, an OPIOID ANALGESICS with naloxone, a NARCOTIC ANTAGONISTS to reduce the potential for NARCOTIC DEPENDENCE in the treatment of pain. It may also be used for OPIOID SUBSTITUTION THERAPY.


Protease F
Fibrinolysin
Fibrogammin
Glu-Plasmin
Plasmin
Thrombolysin

A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.


Cytidine 5'-Diphosphocholine
CDP Choline
Cidifos
Citicholine
Cyticholine
Cytidine Diphosphate Choline
Citicoline

Donor of choline in biosynthesis of choline-containing phosphoglycerides.


Skin Diseases, Bacterial
Bacterial Skin Diseases


Adrenergic beta-2 Antagonists
Adrenergic beta-2 Receptor Blockers
beta-2 Adrenergic Blocking Agents
Adrenergic beta2-Antagonists
Adrenergic beta-2 Receptor Antagonists
beta2-Adrenergic Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-2 RECEPTORS.


T-Lymphotropic Virus Type III Infections, Human

Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).


Techniques, Obstetrical and Gynecological Diagnostic

Technique, Obstetrical and Gynecological Diagnostic

Diagnostic Techniques, Obstetrical and Gynecological

Diagnostic Technics, Obstetrical and Gynecological

Techniques, Obstetric and Gynecologic Diagnostic

Obstetrical and Gynecological Diagnostic Techniques

Diagnostic Technic, Obstetrical and Gynecological

Technique, Obstetric and Gynecologic Diagnostic

Diagnostic Technic, Obstetric and Gynecologic

Diagnostic Technics, Obstetric and Gynecologic

Technics, Obstetrical and Gynecological Diagnostic

Obstetrical and Gynecological Diagnostic Technics

Technic, Obstetrical and Gynecological Diagnostic

Diagnostic Technique, Obstetrical and Gynecological

Obstetric and Gynecologic Diagnostic Technics

Obstetric and Gynecologic Diagnostic Techniques

Diagnostic Techniques, Obstetric and Gynecologic

Technic, Obstetric and Gynecologic Diagnostic

Technics, Obstetric and Gynecologic Diagnostic

Diagnostic Technique, Obstetric and Gynecologic

Methods and procedures for the diagnosis of conditions related to pregnancy, labor, and the puerperium and of diseases of the female genitalia. It includes also demonstration of genital and pregnancy physiology.


Physical Examination
Physical Exam
Examination, Physical
Physical Examinations and Diagnoses

Systematic and thorough inspection of the patient for physical signs of disease or abnormality.


Growth Differentiation Factor 8
Myostatin
GDF-8

A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.


Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.


Those psychological characteristics which differentiate individuals from one another.


Alimentary System
Ailmentary System
Digestive System

A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).


Plant Mycology
Plant Bacteriology
Plant Virology
Plant Pathology
Phytopathology

Study of plant diseases of bacterial origin.


An order of EUKARYOTES found in the gut of termites and other insects that live on LIGNIN. MITOCHONDRIA and GOLGI APPARATUS are absent from oxymonads.


DNA sequences that form the coding region for a protein that down-regulates the expression of human immunodeficiency virus (HIV). nef is short for negative factor.


Dental Implants, Single-Tooth
Single-Tooth Dental Implants
Single-Tooth Implants
Dental Implant, Single-Tooth
Implant, Single-Tooth Dental
Implants, Single-Tooth Dental
Single-Tooth Dental Implant

Devices, usually alloplastic, surgically inserted into or onto the jawbone, which support a single prosthetic tooth and serve either as abutments or as cosmetic replacements for missing teeth.


Gaseous Secondary Messengers
Gasotransmitters
Gaseous Signal Transducers
Gaseous Mediators
Gaseous Messenger Molecules

Endogenously produced lipid-soluble gaseous molecules which function as neurotransmitters and signal mediators targeting ION CHANNELS and transporters.


An adenosine monophosphate analog in which ribose is replaced by an arabinose moiety. It is the monophosphate ester of VIDARABINE with antiviral and possibly antineoplastic properties.


Associated Virus
Satellite Viruses
Virus, Associated
Associated Viruses
Viruses, Associated

Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.


Solute Carrier Family 9 Member 3
Na(+)-H(+) Exchanger 3
NHE-3 Protein
Sodium-Hydrogen Exchanger 3
SLC9A3 Protein

A sodium-hydrogen antiporter expressed primarily by EPITHELIAL CELLS in the kidneys, it localizes to the apical membrane of the PROXIMAL KIDNEY TUBULE, where it functions in sodium and water reabsorption and possibly calcium homeostasis.  It also is expressed in heart, brain, and lung tissues and is resistant to AMILORIDE inhibition.


Surgical Hemorrhage
Surgical Blood Loss
Blood Loss, Surgical
Hemorrhage, Surgical

Loss of blood during a surgical procedure.


Periodontal Splints
Splints, Periodontal

Fixed or removable devices that join teeth together. They are used to repair teeth that are mobile as a result of PERIODONTITIS.


Polyol Dehydrogenase
Sorbitol Dehydrogenase
L-Iditol 2-Dehydrogenase
Iditol Dehydrogenase

An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of NAD. It also acts on D-glucitol to form D-fructose. It also acts on other closely related sugar alcohols to form the corresponding sugar. EC 1.1.1.14


Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.


Oxidoreductases Acting on CH-NH Group Donors

Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.


Respiratory Alkalosis
Alkalosis, Respiratory

A state due to excess loss of carbon dioxide from the body. (Dorland, 27th ed)


GDF-15
Prostate Differentiation Factor
Macrophage Inhibitory Cytokine 1
Growth Differentiation Factor 15

A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.


Bibliography, National
Bibliographies, National
National Bibliographies
National Bibliography

A bibliography which lists all the books and other publications published, or distributed in significant quantity, in a particular country. Sometimes the term is used with respect to the new publications published within a specific period, and sometimes with respect to all those published within a lengthy period of many years. It is also used to indicate a bibliography of publications about a country (whether written by its nationals or not) and those written in the language of the country as well as those published in it. (Harrod's Librarians' Glossary, 7th ed)


Hemorrhagic Disease Virus, Rabbit
Rabbit Haemorrhagic Disease Virus
Rabbit hemorrhagic disease virus

A species in the genus LAGOVIRUS which causes hemorrhagic disease, including hemorrhagic septicemia, in rabbits.


Receptor Capping
Aggregation, Receptor
Capping, Receptor
Receptor Aggregation

Chemically stimulated aggregation of cell surface receptors, which potentiates the action of the effector cell.


Society, Hospital
Hospital Societies
Hospital Society
Societies, Hospital

Societies having institutional membership limited to hospitals and other health care institutions.


E2F-2 Protein
E2F2 Transcription Factor
Transcription Factor E2F-2
E2F2 Protein
E2F Transcription Factor 2 Protein

An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A. E2F2 activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis.


Phosphoinositide Selective Phospholipase C

Phosphoinositol Specific Phospholipase C

A type C phospholipase with specificity towards PHOSPHATIDYLINOSITOLS that contain INOSITOL 1,4,5-TRISPHOSPHATE. Many of the enzymes listed under this classification are involved in intracellular signaling.


Congenital locomotor ataxia of lambs, thought to be associated with copper deficiency. It is characterized clinically by progressive incoordination of the hind limbs and pathologically by disruption of neuron and myelin development in the central nervous system. It is caused by a deficiency of metabolizable copper in the ewe during the last half of her pregnancy. (Dorland, 28th ed; Stedman, 26th ed)


Nicotine Dependence
Tobacco Use Disorder
Tobacco Dependence
Tobacco-Use Disorder
Nicotine Use Disorder

Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.


Pituitary Gland Function Tests
Pituitary Function Tests

Examinations that evaluate functions of the pituitary gland.


Dysfunctional Uterine Bleeding
Intermenstrual Bleeding
Metrorrhagia
Spotting
Breakthrough Bleeding
Bleeding Between Periods

Abnormal uterine bleeding that is not related to MENSTRUATION, usually in females without regular MENSTRUAL CYCLE. The irregular and unpredictable bleeding usually comes from a dysfunctional ENDOMETRIUM.


Platinum Compounds
Plantinum-Containing Compounds
Platinum Compounds, Inorganic

Inorganic compounds which contain platinum as the central atom.


Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).


Lavender
Lavandula
Lavandula angustifolia


Atrial Ectopic Beats
Atrial Premature Complexes
Premature Atrial Contractions
Premature Supraventricular Beats
Premature Atrial Complex
Extrasystole, Atrial
Premature Atrial Beats
Atrial Premature Complex

A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites. The ectopic signals may or may not conduct to the HEART VENTRICLES. Atrial premature complexes are characterized by premature P waves on ECG which are different in configuration from the P waves generated by the normal pacemaker complex in the SINOATRIAL NODE.


Diseases, Pulmonary
Lung Diseases
Disease, Pulmonary
Pulmonary Disease
Pulmonary Diseases

Pathological processes involving any part of the LUNG.


Day Care
Day Care, Medical
Hospitalization, Partial

Institutional health care of patients during the day. The patients return home at night.


ralGDS
ral Guanine Nucleotide Exchange Factor
ral-GDS
ral GDP Dissociation Stimulator

A guanine nucleotide exchange factor that stimulates the dissociation of GDP from RAL GTP-BINDING PROTEINS. It also has GDP exchange activity towards other MONOMERIC GTP-BINDING PROTEINS.


The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.


Hemagglutinating Virus of Japan
Sendai virus

The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.


DMDT
Methoxychlor
Metox
Dianisyl Trichloroethane

An insecticide. Methoxychlor has estrogenic effects in mammals, among other effects.


Bovine ephemeral fever virus
Ephemeral Fever Virus, Bovine

The type species of EPHEMEROVIRUS causing disease in cattle. Transmission is by hematophagous arthropods and the virus has been isolated from both culicoides and mosquitoes.


Patched Receptor-2
Patched-2 Protein
Patched Homolog-2
Patched-2 Receptor
PTCH2 Protein

A patched receptor that may function redundantly with the PATCHED-1 RECEPTOR to modulate hedgehog signaling. It may also play a role in epidermal development and as a TUMOR SUPPRESSOR PROTEIN. Mutations in the patched-2 gene are associated with BASAL CELL NEVUS SYNDROME; CARCINOMA, BASAL CELL; and MEDULLOBLASTOMA.


Serotonin 5-HT4 Receptor Agonists
5-HT4 Agonist
5-HT4 Agonists

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS.


Channel Blockers, Potassium
Potassium Channel Blockers

A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.


Swift Disease
Chronic Childhood Mercurialism
Feer Disease
Acrodynic Erythema
Acrodynia
Swift's Disease
Pink Disease
Feer's Disease

A condition seen primarily in childhood, most often resulting from chronic exposure to MERCURY COMPOUNDS which may result in encephalopathy and POLYNEUROPATHY. Clinical features include pain, swelling and pinkish discoloration of the fingers and toes, weakness in the extremities, extreme irritability, HYPERESTHESIA, and alterations in level of consciousness. (From Menkes, Textbook of Child Neurology, 5th ed, p603)


Primary Hypoadrenalism
Primary Adrenocortical Insufficiency
Addison's Disease
Addison Disease
Primary Adrenal Insufficiency

An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.


National Center for Health Care Technology, U.S.

United States National Center for Health Care Technology

National Center for Health Care Technology (U.S.)

United States Nat'l Center for Health Care Technology

A center in the PUBLIC HEALTH SERVICE which coordinates and administers a program of research, demonstrations, and evaluations of medical technologies and assessments of health care technology.


Dyspraxia, Ideomotor
Apraxia, Ideokinetic
Apraxia, Limb Kinetic
Classic Apraxia
Apraxia, Transcortical
Ideomotor Apraxia
Apraxia, Ideomotor

A form of apraxia characterized by an acquired inability to carry out a complex motor activity despite the ability to mentally formulate the action. This condition has been attributed to a disruption of connections between the dominant parietal cortex and supplementary and premotor cortical regions in both hemispheres. (From Adams et al., Principles of Neurology, 6th ed, p57)


HTH Motifs
Motifs, Helix-Turn-Helix
Helix-Turn-Helix Motifs

The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)


The application of STATISTICS to biological systems and organisms involving the retrieval or collection, analysis, reduction, and interpretation of qualitative and quantitative data.


Rehydration Solutions
Solutions, Rehydration

Fluids restored to the body in order to maintain normal water-electrolyte balance.


Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.


Microscopy, Scanning Probe
Scanning Probe Microscopy

Scanning microscopy in which a very sharp probe is employed in close proximity to a surface, exploiting a particular surface-related property. When this property is local topography, the method is atomic force microscopy (MICROSCOPY, ATOMIC FORCE), and when it is local conductivity, the method is scanning tunneling microscopy (MICROSCOPY, SCANNING TUNNELING).


Anterior Compartment Syndrome
Anterior Tibial Syndrome

Rapid swelling, increased tension, pain, and ischemic necrosis of the muscles of the anterior tibial compartment of the leg, often following excessive PHYSICAL EXERTION.


Invadopodia Invadosomes Podosomes Invadopodium

Actin-rich adhesive structures found at the ventral surface of metazoan ENDOTHELIAL CELLS. When found  in cultured cancer cells they are referred to as invadopodia. These are matrix-degrading structures composed of an ACTIN CYTOSKELETON core and an INTEGRINS-containing ring complex.


Children, Exceptional
Exceptional Child
Child, Exceptional

A child whose needs, abilities, or other characteristics vary so much from the average in mental, physical, or social areas that a greater than usual level of services is needed to facilitate the child's maximum potential development.


Glutamate Dehydrogenase (NADP+)
NADPH-Dependent Glutamate Dehydrogenase
NADP-Specific Glutamate Dehydrogenase
NADP-Dependent Glutamate Dehydrogenase
NADP+-Dependent Glutamate Dehydrogenase

An enzyme that catalyzes the conversion of L-glutamate, H2O, and NADP+ to 2-oxoglutarate, NH3, and NADPH. (From Enzyme Nomenclature, 1992) EC 1.4.1.4.


Dermatosis, Neutrophilic, Febrile, Acute

Condition characterized by large, rapidly extending, erythematous, tender plaques on the upper body usually accompanied by fever and dermal infiltration of neutrophilic leukocytes. It occurs mostly in middle-aged women, is often preceded by an upper respiratory infection, and clinically resembles ERYTHEMA MULTIFORME. Sweet syndrome is associated with LEUKEMIA.


Deoxyribonucleic acid that makes up the genetic material of protozoa.


beta-N-Acetylhexosaminidase beta-N-Acetyl-D-hexosaminidase N-Acetyl-beta-D-hexosaminidase beta-N-Acetylhexosaminidases beta-N-Acetyl-hexosaminidase beta-Hexosaminidase

A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.


Korsakoff Psychosis
Korsakoff Syndrome
Wernicke-Korsakoff Syndrome

An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is frequently associated with chronic ALCOHOLISM; but it may also result from dietary deficiencies; CRANIOCEREBRAL TRAUMA; NEOPLASMS; CEREBROVASCULAR DISORDERS; ENCEPHALITIS; EPILEPSY; and other conditions. (Adams et al., Principles of Neurology, 6th ed, p1139)


An annexin family member that plays a role in MEMBRANE FUSION and signaling via VOLTAGE-DEPENDENT CALCIUM CHANNELS.


Polyinosinic-Polycytidylic Acid (High MW)

Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.


Autopsy
Postmortem Examination
Post-Mortem Examination
Autopsies


A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.


Prostaglandin Endoperoxide Analogs
Prostaglandin Endoperoxide Analogues
Synthetic Prostaglandin Endoperoxides
Prostaglandin Endoperoxides, Synthetic

Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.


Out-of-Hospital Cardiac Arrest
Out-of-Hospital Heart Arrest

Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.


Maternal-Fetal Exchange
Transplacental Exposure

Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.


Interdigitating Dendritic Cell Sarcoma
Dendritic Cell Sarcoma, Interdigitating
Interdigitating Cell Sarcoma

A rare sarcoma of INTERDIGITATING CELLS found in the lymph nodes and non-lymphoid organs. They exhibit a variable immunophenotype and lack Birbeck granules.


A granulomatous disease caused by KLEBSIELLA RHINOSCLEROMATIS infection. Despite its name, this disease is not limited to the nose and NASOPHARYNX but may affect any part of the RESPIRATORY TRACT, sometimes with extension to the lip and the skin.


N(6)-Phenylisopropyl-Adenosine Phenylisopropyladenosine L-Phenylisopropyladenosine Isopropylphenyladenosine

N-Isopropyl-N-phenyl-adenosine. Antilipemic agent. Synonym: TH 162.


The act or practice of engaging in sexual relations for money or other benefit.


MPTP-Induced Degeneration of the Striatum

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)


Single chain carbohydrates that are the most basic units of CARBOHYDRATES. They are typically colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn.


Dermatosis
Dermatoses
Skin Diseases
Skin and Subcutaneous Tissue Disorders

Diseases involving the DERMIS or EPIDERMIS.


NF-E1C Protein
Transcription Factor GATA3
Nuclear Factor-Erythroid 1C
GATA3 Transcription Factor
GATA-3 Factors

A GATA transcription factor that is found predominately in LYMPHOID CELL precursors and has been implicated in the CELL DIFFERENTIATION of HELPER T-CELLS. Haploinsufficiency of GATA3 is associated with HYPOPARATHYROIDISM; SENSORINEURAL HEARING LOSS; and renal anomalies syndrome.


An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.


Transcription Factor POU
POU Domain Factors
Pit-Oct-Unc Proteins
POU Proteins

A family of transcription factors characterized by the presence of a bipartite DNA-binding domain known as the POU domain. The POU domain contains two subdomains, a POU-specific domain and a POU-homeodomain. The POU domain was originally identified as a region of approximately 150 amino acids shared between the Pit-1, Oct-1, Oct-2, and Unc-86 transcription factors.


Piperidinediols
5-Imino-Pyranoses
Imino Pyranoses
1,5-Imino Sugars
1-N-Imino Sugars

Six-carbon pyranose sugars in which the OXYGEN is replaced by a NITROGEN atom.


Central Venous Pressure
Venous Pressure, Central

The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.


Neutral Amino Acid Transport Defect
Transport Disorder, Neutral Amino Acids
Hartnup Disease
Transport Disorder, Neutral Amino Acid
Hartnup Disorder
Amino Acid Transport Disorder, Neutral
Neutral Amino Acid Transport Disorder

An autosomal recessive disorder due to defective absorption of NEUTRAL AMINO ACIDS by both the intestine and the PROXIMAL RENAL TUBULES. The abnormal urinary loss of TRYPTOPHAN, a precursor of NIACIN, leads to a NICOTINAMIDE deficiency, PELLAGRA-like light-sensitive rash, CEREBELLAR ATAXIA, emotional instability, and aminoaciduria. Mutations involve the neurotransmitter transporter gene SLC6A19.


Methyl Mercury Compounds
Methylmercury Compounds

Organic compounds in which mercury is attached to a methyl group.


HPV DNA Tests
Human Papillomavirus DNA Tests

Methods for detecting or typing the DNA of an ALPHAPAPILLOMAVIRUS in biological tissues and fluids.


Diuretics, Potassium Sparing
Potassium Sparing Diuretics

A subclass of diuretics that limits the secretion of POTASSIUM into the URINE.


Iduronate Sulfatase
Hunter Corrective Factor
Iduronatesulfate Sulfohydrolase
Iduronate Sulfate Sulfatase
Sulfoiduronate Sulfatase

An enzyme that specifically cleaves the ester sulfate of iduronic acid. Its deficiency has been demonstrated in Hunter's syndrome, which is characterized by an excess of dermatan sulfate and heparan sulfate. EC 3.1.6.13.


ras Oncogene Protein p21
p21(v-H-ras)
p21 Transforming Viral Protein
p21 v-ras
p21(v-K-ras)
p21(v-Ki-ras)
Oncogene Protein p21(ras)
p21 v-Ki-ras
ras Oncogene Product p21
ras Oncogene p21 Product
p21 v-Ha-ras
p21 v-H-ras
p21(v-Ha-ras)

Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.


The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


Scala Media
Ductus Cochlearis
Cochlear Duct

A spiral tube that is firmly suspended in the bony shell-shaped part of the cochlea. This ENDOLYMPH-filled cochlear duct begins at the vestibule and makes 2.5 turns around a core of spongy bone (the modiolus) thus dividing the PERILYMPH-filled spiral canal into two channels, the SCALA VESTIBULI and the SCALA TYMPANI.


Antigen, Proliferating Cell Nuclear
Proliferating Cell Nuclear Antigen
PCNA

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.


CD22 Antigen
Antigens, CD22
CD22 Glycoprotein
B-Lymphocyte Cell Adhesion Molecule
CD22 Antigens
Sialic Acid Binding Ig-like Lectin 2
Siglec-2

A lectin and cell adhesion molecule found in B-LYMPHOCYTES. It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS.


A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of nursing care.


An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.


Grafil
Composipost
Carbon Fibre
Carbon Felt
Carbon Fiber

Fiber with a diameter of approximately 5 to 10 micrometers that is composed mostly of carbon atoms. It has a variety of applications.


Nuclear Reprogramming
Cell Reprogramming
Cellular Reprogramming

The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state.


The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.


CDP-Choline 1,2-Diglyceride Choline Phosphotransferase

An enzyme that catalyzes the synthesis of phosphatidylcholines from CDPcholine and 1,2-diacylglycerols. EC 2.7.8.2.


Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3

A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.


3,4,5-Trihydroxybenzoic Acid
Gallic Acid

A colorless or slightly yellow crystalline compound obtained from nutgalls. It is used in photography, pharmaceuticals, and as an analytical reagent.


The identification, analysis, and resolution of moral problems that arise in the care of patients. (Bioethics Thesaurus)


Bacteriophage Typing
Phage Typing
Typing, Bacteriophage

A technique of bacterial typing which differentiates between bacteria or strains of bacteria by their susceptibility to one or more bacteriophages.


Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.


L-Gulonooxidase
L-Gulono-Gamma-Lactone Oxidase
L-Gulono-Gamma-Lactone Dehydrogenase
L-Gulonolactone Oxidase

An enzyme involved in the metabolism of ASCORBIC ACID and aldarate. It catalyzes the oxidation of L-gulono-1,4-lactone to L-xylo-hex-3-ulonolactone.


Religious Hospitals
Hospitals, Religious

Private hospitals that are owned or sponsored by religious organizations.


Enterobacteria
Sodalis
Paracolobactrum
Enterobacteriaceae
Ewingella
Leclercia
Coliform Bacilli

A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.


Gene Knock In
Gene Knock-In
Gene Knock-In Techniques
Gene Knock In Techniques

Techniques used to add in exogenous gene sequence such as mutated genes; REPORTER GENES, to study mechanisms of gene expression; or regulatory control sequences, to study effects of temporal changes to GENE EXPRESSION.


The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.


Central Nervous System Parasitic Infections

Parasitic Infections, Central Nervous System

Infections, Central Nervous System, Parasitic

Infections, Parasitic, Central Nervous System

Infections of the brain, spinal cord, and meninges caused by parasites.


Moving and Lifting Patients
Patient Moving and Lifting
Patient Moving
Patient Handling
Patient Lifting
Patient Repositioning

Physical management of the patient while they are being moved or lifted, or during rehabilitation.


Mercaptovaline
Copper Penicillaminate
Cuprimine
D-3-Mercaptovaline
beta,beta-Dimethylcysteine
Cuprenil
Penicillamine
Dimethylcysteine
Metalcaptase
D-Penicillamine

3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.


Mechanotransduction, Cellular
Signal Transduction, Mechanical
Cellular Mechanotransduction
Mechanosensory Transduction

The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory.


Mitochondrion, Heart
Mitochondria, Heart
Myocardial Mitochondria
Heart Mitochondria


Nuchal Cord
Single Nuchal Cord
Fetal Cord Entanglement
Double Nuchal Cord
Triple Nuchal Cord
Quadruple Nuchal Cord

A complication of pregnancy in which the UMBILICAL CORD wraps around the fetal neck once or multiple times. In some cases, cord entanglement around fetal neck may not affect pregnancy outcome significantly. In others, the nuchal cord may lead to restricted fetal blood flow, oxygen transport, fetal development, fetal movement, and complicated delivery at birth.


Tarui Disease
Deficiency, Muscle Phosphofructokinase
Glycogenosis 7
Glycogen Storage Disease VII
Tarui's Disease
Muscle Phosphofructokinase Deficiency
Glycogen Storage Disease Type VII
Pfkm Deficiency
GSD VII

An autosomal recessive glycogen storage disease in which there is deficient expression of 6-phosphofructose 1-kinase in muscle (PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE) resulting in abnormal deposition of glycogen in muscle tissue. These patients have severe congenital muscular dystrophy and are exercise intolerant.


Vehicle Emissions
Automobile Exhaust
Traffic-Related Pollutants
Vehicular Emissions
Engine Exhaust
Diesel Exhaust
Transportation Emissions

Gases, fumes, vapors, and ODORANTS escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)


The process of SMOKING specific to TOBACCO.


Factor 11A
Coagulation Factor XIa
Activated Factor XI
Factor XI, Activated
Factor XIa
Contact Activation Product
Blood Coagulation Factor XI, Activated
Factor Eleven A

Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.


Hepatitis, Viral, Animal
Viral Hepatitis, Animal

INFLAMMATION of the LIVER in animals due to viral infection.


Antigens, CD164
CD164 Antigen
Endolyn
CD164 Antigens

A sialomucin protein that functions as a cell adhesion molecule. It is a negative regulator of certain types of HEMATOPOIETIC STEM CELLS.


Molecular Probe
Probes, Molecular
Probe, Molecular
Molecular Probes

A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.


Glucose Metabolism Disorder
Glucose Metabolism Disorders
Glucose Metabolic Disorder
Glucose Metabolic Disorders

Pathological conditions in which the BLOOD GLUCOSE cannot be maintained within the normal range, such as in HYPOGLYCEMIA and HYPERGLYCEMIA. Etiology of these disorders varies. Plasma glucose concentration is critical to survival for it is the predominant fuel for the CENTRAL NERVOUS SYSTEM.


Rhodospirillaceae
Bacteria, Purple Nonsulfur
Purple Nonsulfur Bacteria

A family of phototrophic bacteria, in the order Rhodospirillales, isolated from stagnant water and mud.


Hypokalemic Periodic Paralysis, Familial

An autosomal dominant familial disorder characterized by recurrent episodes of skeletal muscle weakness associated with falls in serum potassium levels. The condition usually presents in the first or second decade of life with attacks of trunk and leg paresis during sleep or shortly after awakening. Symptoms may persist for hours to days and generally are precipitated by exercise or a meal high in carbohydrates. (Adams et al., Principles of Neurology, 6th ed, p1483)


Rh Factors
Rh-Hr Blood-Group System
Antigen D, Rh Blood Group
Rhesus Blood-Group System

Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.


A class of acids containing a ring structure in which at least one atom other than CARBON is incorporated.


Agrobacterium tumefaciens
Rhizobium radiobacter
Agrobacterium radiobacter

A species of gram-negative, aerobic bacteria isolated from soil and the stems, leafs, and roots of plants. Some biotypes are pathogenic and cause the formation of PLANT TUMORS in a wide variety of higher plants. The species is a major research tool in biotechnology.


Solute Carrier Family-7 (Cationic Amino Acid Transporter, y+ System), Member 5

A CD98 antigen light chain that when heterodimerized with CD98 antigen heavy chain (FUSION REGULATORY PROTEIN-1 HEAVY CHAIN) forms a protein that mediates sodium-independent L-type amino acid transport.


Statement of the position requirements, qualifications for the position, wage range, and any special conditions expected of the employee.


A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.


Zoalene Dinitrotoluamide Methyldinitrobenzamide Dinitolmide Coccidot


Pre-Symptomatic Diseases
Asymptomatic Conditions
Asymptomatic States
Presymptomatic Diseases
Asymptomatic Diseases


A hydrocarbon used as an industrial solvent. It has been used as an aerosal propellent, as a refrigerant and as a local anesthetic. (From Martindale, The Extra Pharmacopoeia, 31st ed, p1403)


A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.


Eck RPTK Ligand
Eck Ligand
LERK-1 Protein
Epl1 Protein
Ephrin-A1
EPLG1
B61 Secreted Protein, Endothelium
Endothelium Secreted Protein B61

An ephrin that was originally identified as the product of an early response gene induced by TUMOR NECROSIS FACTORS. It is linked to the CELL MEMBRANE via a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR and binds EPHA2 RECEPTOR with high affinity. During embryogenesis high levels of ephrin-A1 are expressed in LUNG; KIDNEY; SALIVARY GLANDS; and INTESTINE.


High Cardiac Output
Cardiac Output, High

A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. These conditions may include ANEMIA; ARTERIOVENOUS FISTULA; THYROTOXICOSIS; PREGNANCY; EXERCISE; FEVER; and HYPOXIA. In time, compensatory changes of the heart can lead to pathological form of high cardiac output and eventual HEART FAILURE.


Compounds based on a propanolamine attached via an OXYGEN atom to a phenoxy ring. The side chain is one carbon longer than PHENYLETHYLAMINES.


Condensation products of aromatic amines and aldehydes forming azomethines substituted on the N atom, containing the general formula R-N:CHR. (From Grant & Hackh's Chemical Dictionary, 5th ed)


Echovirus 9, Human
Echo Virus 9
Human echovirus 9
Echovirus 9

A species of ENTEROVIRUS associated with outbreaks of aseptic meningitis (MENINGITIS, ASEPTIC).


Obstetrical Analgesia
Analgesia, Obstetric
Analgesia, Obstetrical

The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.


Procollagen C-Endopeptidase
Bone Morphogenetic Protein 1

A bone morphogenetic protein family member that includes an active tolloid-like metalloproteinase domain. The metalloproteinase activity of bone morphogenetic protein 1 is specific for the removal of the C-propeptide of PROCOLLAGEN and may act as a regulator of EXTRACELLULAR MATRIX deposition. Alternative splicing of MRNA for bone morphogenetic protein 1 results in the production of several PROTEIN ISOFORMS.


The articulations between the various CARPAL BONES. This does not include the WRIST JOINT which consists of the articulations between the RADIUS; ULNA; and proximal CARPAL BONES.


Toxic, chlorinated, saturated hydrocarbons. Include both the 1,1- and 1,2-dichloro isomers. The latter is considerably more toxic. It has a sweet taste, ethereal odor and has been used as a fumigant and intoxicant among sniffers. Has many household and industrial uses.


Mastigomycotina
Batrachochytrium dendrobatidis
Chytridiomycota

A species of Chytridiomycota fungi that is the causative agent of chytridiomycosis in amphibians.


Giant Cells, Langhans
Langhans Giant Cells
Langhans-Type Giant Cells

Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.


Nicocap
Niacin Aluminum Salt
Niacin Potassium Salt
Niacin Hydrochloride
Nicotinic Acid
Niacin Tartrate
Lithium Nicotinate
Nicotinate
Niacin Magnesium Salt
Induracin
Niacin Zinc Salt
Niacin Calcium Salt
Niacin Tosylate
Niacin Manganese (2+) Salt
Niacin Sodium Salt
Nicobid
Nicolar
3-Pyridinecarboxylic Acid
Niacin Cobalt (2+) Salt
Nicamin
Niacin Copper (2+) Salt
Niacin
Niacin Ammonium Salt
Enduracin
Niacin Iron (2+) Salt
Niacin Lithium Salt
Niacin Lithium Salt, Hemihydrate
Nico-400
Wampocap

A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.


Methylnitrosourea N-Methyl-N-nitrosourea NSC-23909 Nitrosomethylurea

A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.


Zonula Occludens Proteins
Zona Occludens Proteins

A family of proteins that play a role in TIGHT JUNCTION formation by binding to and anchoring proteins to the ACTIN CYTOSKELETON.


School, Pharmacy
Schools, Pharmacy
Pharmacy School
Pharmacy Schools

Educational institutions for individuals specializing in the field of pharmacy.


Schools, Health Occupations
Health Occupations Schools

Schools which offer training in the area of health.


Rhodobacter spheroides
Rhodobacter sphaeroides
Rhodopseudomonas sphaeroides
Rhodopseudomonas spheroides

Spherical phototrophic bacteria found in mud and stagnant water exposed to light.


Protein Structure, Quaternary
Quaternary Protein Structure

The characteristic 3-dimensional shape and arrangement of multimeric proteins (aggregates of more than one polypeptide chain).


Immunity, Cellular
Cellular Immune Response
Cell-Mediated Immunity

Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.


Anodynin Antipyrine Pyramidone Phenazone

An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)


A constituent element or influence that could be used in studies for racial disparities as variables such as those related to risk factors and disease and or differential access to services.


A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.


Lymphangioma, Cystic
Cystic Hygroma Colli
Hygroma, Cystic
Hygroma

A cystic growth originating from lymphatic tissue. It is usually found in the neck, axilla, or groin.


Radioactive Elements
Elements, Radioactive

Unstable elements with atomic numbers greater than 83 that exist in nature solely as radioisotopes.


Benzoporphyrin Derivative Monoacid Ring A

A benzoporphyrin derivative that is used in PHOTOCHEMOTHERAPY to treat wet type MACULAR DEGENERATION.


Bacillary Peliosis
Bacillary Angiomatosis
Angiomatosis, Epithelioid
Angiomatosis, Bacillary
Angiomatosis, Bacillary Epithelioid

A reactive vascular proliferation that is characterized by the multiple tumor-like lesions in skin, bone, brain, and other organs. Bacillary angiomatosis is caused by infection with gram-negative Bartonella bacilli (such as BARTONELLA HENSELAE), and is often seen in AIDS patients and other IMMUNOCOMPROMISED HOSTS.


Tyrosine Transaminase
Tyrosine Aminotransferase

An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.


A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*13 and DRB1*14 alleles.


Antibiotic pigment produced by Pseudomonas aeruginosa.


Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.


Instruments designed to inspect or auscultate the ear. They are designed primarily to examine the outer ear canal and tympanic membrane by means of light and air under moderate pressure, as with a pneumatic otoscope. (UMDNS, 1999)


Medial Plantar Neuropathy
Internal Popliteal Neuropathy
Tibial Nerve Diseases
Posterior Tibial Neuropathy
Medial Plantar Nerve Disease
Lateral Plantar Neuropathy
Posterior Tibial Nerve Diseases
Tibial Neuropathy
Medial Popliteal Neuropathy
Tibial Neuropathy, Post-Traumatic

Disease of the TIBIAL NERVE (also referred to as the posterior tibial nerve). The most commonly associated condition is the TARSAL TUNNEL SYNDROME. However, LEG INJURIES; ISCHEMIA; and inflammatory conditions (e.g., COLLAGEN DISEASES) may also affect the nerve. Clinical features include PARALYSIS of plantar flexion, ankle inversion and toe flexion as well as loss of sensation over the sole of the foot. (From Joynt, Clinical Neurology, 1995, Ch51, p32)


Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.


Group VI Phospholipases A2
iPLA(2)-2
Group VI Phospholipase A(2)
iPLA(2)-1
Group VI Phospholipase A2
Phospholipases A2, Group VI

A calcium-independent phospholipase A2 group that may play a role in membrane phospholipid remodeling and homeostasis by controling the levels of PHOSPHATIDYLCHOLINE in mammalian cell membranes.


A condition with abnormally low levels of PREBETA-LIPOPROTEINS in the blood.


Alveolar Resorption
Alveolar Process Atrophy
Periodontal Resorption
Bone Loss, Alveolar
Alveolar Bone Loss
Periodontal Bone Loss
Bone Loss, Periodontal
Alveolar Bone Atrophy

Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.


Metabotropic Glutamate Receptors
Receptors, Glutamate, Metabotropic
Metabotropic Glutamate Receptor
Glutamate Receptors, Metabotropic
Receptors, Metabotropic Glutamate

Cell surface proteins that bind glutamate and act through G-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action.


Case-Base Studies
Nested Case-Control Studies
Case-Referent Studies
Case-Referrent Studies
Case-Compeer Studies
Case-Control Studies
Matched Case-Control Studies
Case-Comparison Studies
Case Control Studies

Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time.


Nuclear Receptor Subfamily 1, Group D, Member 1

A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.


Medetomidine Hydrochloride
Medetomidine
Levomedetomidine
MPV-785

An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.


Zebrafishes
Zebrafish
Brachydanio rerio
D. rerio
Zebra Fish
Danio rerio
Zebra danio
B. rerio
Zebra Fishes

An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. Zebrafish is a model organism for drug assay and cancer research.


Dopamine D2 Receptor Antagonists
Receptor Antagonists, Dopamine D2
Dopamine D2 Antagonists

Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS.


Nitrogen Species, Reactive
Reactive Nitrogen Species

Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.


Leukotriene B4 Receptors
LTB4 Receptor
Receptors, Leukotriene B4
LTB4 Receptors
Leukotriene B4 Receptor

A class of cell surface leukotriene receptors with a preference for leukotriene B4. Leukotriene B4 receptor activation influences chemotaxis, chemokinesis, adherence, enzyme release, oxidative bursts, and degranulation in polymorphonuclear leukocytes. There are at least two subtypes of these receptors. Some actions are mediated through the inositol phosphate and diacylglycerol second messenger systems.


Mitochondria, Liver
Liver Mitochondrion
Mitochondrion, Liver
Liver Mitochondria

Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)


GABA-A Agonists
GABA-A Receptor Agonist
GABA-A Receptor Agonists

Endogenous compounds and drugs that bind to and activate GABA-A RECEPTORS.


WHO
Organization, World Health
World Health Organization

A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.


A trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.


Automated Medical Records System
Computerized Medical Records System
Medical Record Systems, Computerized
Computerized Patient Medical Records
Automated Medical Record Systems
Medical Records System, Computerized
Medical Records Systems, Automated
Computerized Medical Records Systems
Medical Record System, Automated
Medical Record Systems, Automated
Computerized Medical Record System
Automated Medical Record System
Automated Medical Records Systems
Medical Records Systems, Computerized
Medical Records System, Automated
Medical Record System, Computerized
Computerized Medical Record Systems

Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.


K-Strophanthidin Corchsularin Cymarigenin Convallatoxigenin Strophanthidin

3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. The aglycone cardioactive agent isolated from Strophanthus Kombe, S. gratus and other species; it is a very toxic material formerly used as digitalis. Synonyms: Apocymarin; Corchorin; Cynotoxin; Corchorgenin.


Molecular Cytogenetic Technics
Cytogenetic Analysis
Cytogenetic Techniques
Molecular Cytogenetic Techniques
Cytogenetic Technics

Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.


A plant genus of the family APIACEAE that is sometimes called Hemlock Water Dropwort but should not be confused with HEMLOCK. It contains enanthotoxin.


An abnormal balloon- or sac-like dilatation in the wall of AORTA.


Animals, Outbred Strains
Outbred Strain of Animal
Outbred Animal Strains
Outbred Strains, Animals
Outbred Strains of Animals

Animals that are generated from breeding two genetically dissimilar strains of the same species.


Drug Prescriptions
Drug Prescription
Drug Prescribing

Directions written for the obtaining and use of DRUGS.


A plant genus of the family Cuscutaceae. It is a threadlike climbing parasitic plant that is used in DRUGS, CHINESE HERBAL.


Personnel Staffing Scheduling Information Systems

Personnel Staffing and Scheduling Information Systems

Computer-based systems for use in personnel management in a facility, e.g., distribution of caregivers with relation to patient needs.


Virus Particle
Viral Particle
Viral Particles
Virion

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.


The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.


Substantia Nigra Compacta
Pars Compacta
Substantia Nigra Pars Compacta

A region in the substantia nigra located dorsal to the PARS RETICULATA.


A protein domain originally identified in DISCOIDINS. It occurs in a variety of unrelated proteins in multicellular organisms, where it recognizes different ligands with distinct biological functions. Structurally, it consists of two antiparallel beta sheets that form a "jellyroll" configuration stabilized by two intramolecular disulfide bonds. Sequence differences within this module determine ligand specificity; in DISCOIDIN DOMAIN RECEPTORS, it binds to FIBRILLAR COLLAGENS and NON-FIBRILLAR COLLAGENS.


Antibiotic substance produced by Streptomyces garyphalus.


Connexin Cx26
beta2 Connexin
Connexin 26
Gap Junction beta-2 protein
Connexin beta-2

A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.


Trehalose Dimycolates
Cord Factor
Cord Factors
Trehalose-6,6'-Dimycolate

Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.


Trichophytosis
Trichophyton mentagrophytes Infection
Dermatophytosis
Ringworm
Epidermophytosis
Dermatophytoses
Tinea

Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.


Flumadine
Remantadine
Riamantadine
Rimantadine
Roflual
Rimantadine Hydrochloride

An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.


Terminal facilities used for aircraft takeoff and landing and including facilities for handling passengers. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed.)


Radio-Frequency Therapy
Radiofrequency Therapy

The use of RADIO WAVES to conduct therapeutic procedures. The specific frequency, dosage, and intensity used vary depending on the desired effects which include heating, electrical stimulation, or ablation of tissues.


A rare, X-linked immunodeficiency syndrome characterized by ECZEMA; LYMPHOPENIA; and, recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IMMUNOGLOBULIN M levels are low and IMMUNOGLOBULIN A and IMMUNOGLOBULIN E levels are elevated. Lymphoreticular malignancies are common.


Central Serous Retinopathy
Central Serous Chorioretinopathy

A visual impairment characterized by the accumulation of fluid under the retina through a defect in the retinal pigment epithelium.


A distinct subnuclear domain enriched in splicesomal snRNPs (RIBONUCLEOPROTEINS, SMALL NUCLEAR) and p80-coilin.


Hippel-Lindau Disease
Lindau Disease
Cerebelloretinal Angiomatosis, Familial
Lindau's Disease
von Hippel-Lindau Disease
von Hippel-Lindau Syndrome
Familial Cerebello-Retinal Angiomatosis
VHL Syndrome
Angiomatosis Retinae

An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions.


RNA, Small Nucleolar
Small Nucleolar RNA
snoRNA

Small nuclear RNAs that are involved in the processing of pre-ribosomal RNA in the nucleolus. Box C/D containing snoRNAs (U14, U15, U16, U20, U21 and U24-U63) direct site-specific methylation of various ribose moieties. Box H/ACA containing snoRNAs (E2, E3, U19, U23, and U64-U72) direct the conversion of specific uridines to pseudouridine. Site-specific cleavages resulting in the mature ribosomal RNAs are directed by snoRNAs U3, U8, U14, U22 and the snoRNA components of RNase MRP and RNase P.


Ballet
Dance
Salsa Dancing
Square Dance
Modern Dance
Dancing
Tap Dance
Line Dancing
Hip-Hop Dance
Jazz Dance

Country dance style that involves couples facing each other in a square following steps that are called out.


Saccharum repens
Rose Natal Grass
Natal Grass
Tricholaena repens
Melinis repens
Rhynchelytrum repens
Tricholaena rosea nees
Rhynchelytrum roseum

Formerly known as Rhynchelytrum repens, a member of the perennial grass family native to South Africa, widely distributed and known by different common names. It is used as a diabetes cure in folk medicine and actively studied for its hypoglycemic properties.


Adenosine A3 Receptor
Receptor, Adenosine A3
Adenosine A3 Receptors

A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.


Congenital Hemolytic Anemia
Anemia, Hemolytic, Hereditary
Hemolytic Anemia, Hereditary
Hemolytic Anemia, Congenital
Hereditary Hemolytic Anemia
Anemia, Hemolytic, Congenital

Hemolytic anemia due to various intrinsic defects of the erythrocyte.


Enviomycin
Tuberactinomycin-N
Tuberactinomycin N

Cyclic basic peptide related to VIOMYCIN. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.


An Ephemerovirus infection of cattle caused by bovine ephemeral fever virus (EPHEMERAL FEVER VIRUS, BOVINE). It is characterized by respiratory symptoms, increased oropharyngeal secretions and lacrimation, joint pains, tremor, and stiffness.


Round Ligament of Uterus
Ligamentum Teres Uteri

A fibromuscular band that attaches to the UTERUS and then passes along the BROAD LIGAMENT, out through the INGUINAL RING, and into the labium majus.


A form of group psychotherapy. It involves treatment of more than one member of the family simultaneously in the same session.


Virus, Western Equine Encephalitis
Encephalomyelitis Virus, Western Equine
Encephalitis Virus, Western Equine
Western Equine Encephalitis Viruses
Encephalitis Viruses, Western Equine
Western equine encephalitis virus
WEE Virus
Viruses, Western Equine Encephalitis

A species of ALPHAVIRUS that is the etiologic agent of encephalomyelitis in humans and equines in the United States, southern Canada, and parts of South America.


A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).


Measurement of this acid in the urine after oral administration of histidine provides the basis for the diagnostic test of folic acid deficiency and of megaloblastic anemia of pregnancy.


Load-Bearing
Weight-Bearing
Loadbearing
Axial Loading
Weightbearing

Application of force along the axis of the body (see AXIS), body parts, or PROSTHESES AND IMPLANTS.


Lymphoma, Mucosa-Associated Lymphoid Tissue

Mucosa-Associated Lymphoid Tissue Lymphoma

Lymphoma of Mucosa-Associated Lymphoid Tissue

Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.


Autobiography as Topic
Autobiographies as Topic

Works about self-described narratives of a person's life.


Glandular Fever
Mononucleosis, Infectious
Infectious Mononucleosis

A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.


Anti-Vaccine Movement
Anti-Vaccination Movement
Anti-Vaccination Groups
Antivaccination Movement
Anti-Vaccine Groups

Group activities directed against VACCINATION.


Baroreceptor Reflexes
Baroreceptor Reflex
Reflex, Baroreceptor
Baroreflexes
Baroreflex

A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.


The subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involved a diverse array of cellular functions including cell division, transport within the GOLGI APPARATUS, and maintaining MICROVILLI structure.


The granting of a license to practice medicine.


Lysinopril
MK-521
Zestril
Lisinopril
Prinivil
Lisinopril Sulfate (1:2)
Lisinopril Maleate (1:1)

One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.


Systemic Sclerosis
Systemic Scleroderma
Sclerosis, Systemic
Scleroderma, Systemic

A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.


Ovulation Prediction
Predicting Ovulation

Predicting the time of OVULATION can be achieved by measuring the preovulatory elevation of ESTRADIOL; LUTEINIZING HORMONE or other hormones in BLOOD or URINE. Accuracy of ovulation prediction depends on the completeness of the hormone profiles, and the ability to determine the preovulatory LH peak.


Alcoholic Cirrhosis
Hepatic Cirrhosis, Alcoholic
Liver Cirrhosis, Alcoholic

FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.


Murine-Derived Monoclonal Antibodies
Antibodies, Monoclonal, Murine-Derived

Antibodies obtained from a single clone of cells grown in mice or rats.


Methacrylic Acid Polymers
Polymethacrylic Acids

Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.


Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.


Genetic Cross
Crosses, Genetic
Genetic Crosses
Cross, Genetic

Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.


A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.


Brain Regeneration
Endogenous Regeneration of Brain


Infectious Disease Outbreaks
Outbreaks
Disease Outbreaks

Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.


Knowledge Bases
Knowledge Bases (Computer)
Knowledgebases

Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).


Archaeal Antibodies
Antibodies, Archaeal

Immunoglobulins produced in a response to ARCHAEAL ANTIGENS.


Membrane Glycoprotein IIb
GP IIb
CD41 Cell Surface Antigen
Antigens, CD41
Plasma Membrane Glycoprotein IIb
Platelet Membrane Glycoprotein IIb
GPalpha IIb
Integrin alpha IIb
CD41 Antigen
HUPL-ml Surface Antigen
Integrin alphaIIb
CD41 Antigens

Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.


Ethylmorphine Hydrochloride, Dihydrate, (5alpha,6alpha)-Isomer

Ethylmorphine Sulfate (2:1), (5alpha,6alpha)-Isomer

A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.


A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.


Calcitonin Gene-Related Peptide Receptors

Calcitonin-Gene Related Peptide Receptor

Receptors, Calcitonin Gene-Related Peptide

Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.


Vibrio salmonicida
Aliivibrio salmonicida

A species of gram-negative bacteria in the genus ALIIVIBRIO. Aliivibrio salmonicida is the causative agent of cold water vibriosis, a HEMORRHAGIC SEPTICEMIA of ATLANTIC SALMON.


Tetraethylammonium Iodide
Tetraethylammonium Ion
Tetraethylammonium Chloride
Tetraethylammonium Hydroxide
Tetraethylammonium
Tetraethylammonium Bromide

A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)


Apo C-II
Apolipoprotein C-2
ApoC2
Apolipoprotein C-II
Apolipoprotein CII
Apoprotein C-II

A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.


Hospital Nuclear Medicine Department
Nuclear Medicine Departments, Hospital
Hospital Nuclear Medicine Departments
Nuclear Medicine Department, Hospital

Hospital department responsible for the administration and management of nuclear medicine services.


A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.


DNA Virus Infections
Infections, DNA Virus


Early Growth Response Transcription Factors

A family of transcription factors that are induced by GROWTH FACTORS and contain a highly conserved DNA-binding domain composed of three ZINC FINGER MOTIFS.


Glutamyl Transpeptidase
GGTP
gammaglutamyltransferase
gamma-Glutamyltransferase
gamma-Glutamyl Transpeptidase

An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.


ADA Inhibitors
Adenosine Deaminase Inhibitors

Drugs that inhibit ADENOSINE DEAMINASE activity.


Ampullary Hair Cells
Hair Cells, Ampulla

Sensory cells in the ampullary crest of each of the semicircular ducts, with their apical STEREOCILIA embedded in a wedge-shaped gelatinous cupula. These hair cells sense the movement of ENDOLYMPH resulting from angular acceleration of the head, and send signals via the VESTIBULAR NERVE to the brain to maintain balance.


Isoetharine Mesylate
Isoetharine
Bronkometer
Isoetarin
Etyprenalinum

Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.


GABA-A Receptor Antagonists
GABA-A Receptor Antagonist
GABA-A Antagonists

Drugs that bind to but do not activate GABA-A RECEPTORS thereby blocking the actions of endogenous or exogenous GABA-A RECEPTOR AGONISTS.


The application of NURSING knowledge to questions of law. It is a specialty of nursing practice involving victims of crime which includes not only attending to the physical and emotional distress of victims, but also the identifying, collecting, and preserving evidence for law enforcement and the criminal justice system.


CDP Diacylglycerols
CDP-Diacylglycerol
Cytidine Diphosphodiacylglycerols
Cytidine Diphosphate Diglycerides
CDP Diglycerides

The ester of diacylglycerol with the terminal phosphate of cytidine diphosphate. It serves as an intermediate in the biosynthesis of phosphatidylethanolamine and phosphatidylserine in bacteria.


Caricature as Topic
Caricatures as Topic

Works about portraying in a critical or facetious way a real individual or group, or a figure representing a social, political, ethnic, or racial type. (Genre Terms: A Thesaurus for Use in Rare Book and Special Collections Cataloguing, 2d ed)


Josamycine
EN-141
Leucomycin A3
Kitasamycin A3
Wilprafen
Turimycin A5
Josamycin

A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.


Tooth Uprighting
Tooth Movement Techniques
Tooth Movement, Minor
Tooth Intrusion
Tooth Depression
Orthodontic Tooth Movement

Orthodontic techniques used to correct the malposition of a tooth or teeth.


Vesicular Stomatitis
Stomatitis, Vesicular

A viral disease caused by at least two distinct species (serotypes) in the VESICULOVIRUS genus: VESICULAR STOMATITIS INDIANA VIRUS and VESICULAR STOMATITIS NEW JERSEY VIRUS. It is characterized by vesicular eruptions on the ORAL MUCOSA in cattle, horses, pigs, and other animals. In humans, vesicular stomatitis causes an acute influenza-like illness.


A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae.


gamma Proteobacteria
Proteobacteria gamma
Gammaproteobacteria

A group of the proteobacteria comprised of facultatively anaerobic and fermentative gram-negative bacteria.


Phasmidia Infections
Infections, Secernentea
Secernentea Infections
Infections, Phasmidia

Infections with nematodes of the subclass SECERNENTEA.


A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.


Ataxin-7
ATXN7 Protein
SCA7 Protein
Spinocerebellar Ataxia 7 Protein
Atxn-7 Protein

A component of the STAGA transcription coactivator-HAT complex that functions in Cone Rod Homeobox Protein (CRX)-dependent gene activation. It also stabilizes MICROTUBULES. CAG repeat expansion in the ATXN-7 coding region is associated with the development of SPINOCEREBELLAR ATAXIA 7.


p65(gag-jun)
v-jun Protein
p65 gag-jun
Oncogene Protein v-jun
Oncogene Protein p65(gag-jun)
Oncogene Product v-jun
Oncogene Protein jun
jun Oncogene Protein
Fusion Proteins, gag-jun

Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kDa derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.


An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.


Substantia Grisea Centralis Mesencephali

Central gray matter surrounding the CEREBRAL AQUEDUCT in the MESENCEPHALON. Physiologically it is probably involved in RAGE reactions, the LORDOSIS REFLEX; FEEDING responses, bladder tonus, and pain.


p-Dihydroxybenzenes Hydroquinones Quinols para-Dihydroxybenzenes

Derivatives of hydroquinone (1,4-dihydrobenzene) made by reduction of BENZOQUINONES.


EAAT-3 Excitatory Amino Acid Transporter

A neuronal and epithelial type glutamate plasma membrane transporter protein.


Carrageenin Carrageenan kappa-Carrageenan lambda-Carrageenan iota-Carrageenan

A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.


Receptors, Toll-Like
Toll-Like Receptors
Toll-Like Receptor

A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.


Psychiatry, Geriatric
Geriatric Psychiatry
Psychogeriatrics

A subspecialty of psychiatry concerned with the mental health of the aged.


UDPglucose 4-Epimerase
UDP Glucose Epimerase
UDP-Galactose 4-Epimerase
UDP Galactose Epimerase
UDP-Glucose 4-Epimerase
Uridine Diphosphate Glucose Epimerase
UDPgalactose 4-Epimerase

A necessary enzyme in the metabolism of galactose. It reversibly catalyzes the conversion of UDPglucose to UDPgalactose. NAD+ is an essential component for enzymatic activity. EC 5.1.3.2.


Esters formed between the aldehydic carbon of sugars and the terminal phosphate of adenosine diphosphate.


Phage mu
mu Phage
Bacteriophage mu
Coliphage mu
Enterobacteria phage Mu

A temperate coliphage, in the genus Mu-like viruses, family MYOVIRIDAE, composed of a linear, double-stranded molecule of DNA, which is able to insert itself randomly at any point on the host chromosome. It frequently causes a mutation by interrupting the continuity of the bacterial OPERON at the site of insertion.


A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.


Subchronic Toxicity Tests
Toxicity Tests, Subchronic

Experiments designed to determine the potential toxic effects of mid-term (a few months) exposure to a chemical or chemicals.


Books, Medical Reference
Reference Books, Medical
Medical Reference Books

Books in the field of medicine intended primarily for consultation.


tat Gene Products, Human Immunodeficiency Virus

Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.


A plant genus of the family RHAMNACEAE. Members contain nummularogenin (a spirostane) and is the source of an edible fruit.


Endothelial Cell-Viability Maintaining Factor

A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.


Papillary Carcinoma Of Thyroid
Thyroid Carcinoma, Papillary
Nonmedullary Thyroid Carcinoma
Thyroid Cancer, Papillary
Familial Nonmedullary Thyroid Cancer
Papillary Thyroid Carcinoma

An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.


Dislocation Fracture
Fracture Dislocation

Fracture of a bone near an articulation with concomitant dislocation of that joint.


A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.


A family of non-enveloped, vertebrate, single-stranded DNA Viruses.


Hormonal Oral Contraceptive Agents
Contraceptive Agents, Oral, Hormonal
Contraceptive Agents, Estrogen
Contraceptives, Oral, Hormonal
Oral Contraceptives, Hormonal
Oral Contraceptive Agents, Hormonal

Oral contraceptives which owe their effectiveness to hormonal preparations.


An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.


Metals with high specific gravity, typically larger than 5. They have complex spectra, form colored salts and double salts, have a low electrode potential, are mainly amphoteric, yield weak bases and weak acids, and are oxidizing or reducing agents (From Grant & Hackh's Chemical Dictionary, 5th ed)


Werner Syndrome RecQ-Like Helicase
RECQL2 Protein
RECQ3 Protein
Werner Syndrome Helicase
Werner Syndrome ATP-Dependent Helicase

A DNA-dependent helicase and 3'-5' exonuclease. It has  3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.


Piriform Fossa
Pyriform Sinus
Piriform Sinus
Piriform Recess

A recess on each side in the wall of the HYPOPHARYNX.


Epidermolysis Bullosa
Acantholysis Bullosa

Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.


Bone Marrow Failure Syndromes, Congenital

Congenital Bone Marrow Failure Syndromes

Bone Marrow Failure Syndromes, Inherited

Inherited syndromes characterized by deficiency or absence of various blood cells due to mutations that affect HEMATOPOIETIC STEM CELLS development and proliferation.


Vascular Endothelium
Capillary Endothelium
Endothelium, Vascular

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.


Hospital-Physician Relations
Physician-Hospital Relations

Includes relationships between hospitals, their governing boards, and administrators in regard to physicians, whether or not the physicians are members of the medical staff or have medical staff privileges.


F-Box and WD-40 Domain-Containing Protein 7

A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.


The dependence of tumor cells on a single oncogenic pathway or protein for their continued proliferation and survival.


Radiation Injuries, Experimental
Injuries, Experimental Radiation
Experimental Radiation Injuries

Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.


Pituitary Melanotropin-Producing Cells
Pituitary MSH-Producing Cells
Melanotrophs

Neuroendocrine cells in the INTERMEDIATE LOBE OF PITUITARY. They produce MELANOCYTE STIMULATING HORMONES and other peptides from the post-translational processing of pro-opiomelanocortin (POMC).


Wnt-4 Protein
Wnt4 Protein
Wnt-4 Proteins

A Wnt protein that is involved in regulating multiple developmental processes such as the formation of the KIDNEY; ADRENAL GLANDS; MAMMARY GLANDS; the PITUITARY GLAND; and the female reproductive system. Defects in WNT4 are a cause of ROKITANSKY KUSTER HAUSER SYNDROME.


Leukemia, Myelomonocytic, Chronic
Myelomonocytic Leukemia, Chronic

A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.


Regulation of the concentration, folding, interactions, and cellular localization of each of the proteins that comprise the PROTEOME.


Human Herpesvirus 4
EBV
Herpesvirus 4 (gamma), Human
HHV-4
Burkitt's Lymphoma Virus
Herpesvirus 4, Human
Infectious Mononucleosis Virus
E-B Virus
Epstein-Barr Virus
Burkitt Lymphoma Virus
Burkitt Herpesvirus

The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.


Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.


Non-therapeutic positive end-expiratory pressure occurring frequently in patients with severe airway obstruction. It can appear with or without the administration of external positive end-expiratory pressure (POSITIVE-PRESSURE RESPIRATION). It presents an important load on the inspiratory muscles which are operating at a mechanical disadvantage due to hyperinflation. Auto-PEEP may cause profound hypotension that should be treated by intravascular volume expansion, increasing the time for expiration, and/or changing from assist mode to intermittent mandatory ventilation mode. (From Harrison's Principles of Internal Medicine, 12th ed, p1127)


Hypochondriasis
Neurosis, Hypochondriacal
Hypochondriacal Neuroses

Preoccupation with the fear of having, or the idea that one has, a serious disease based on the person's misinterpretation of bodily symptoms. (APA, DSM-IV)


Ezetimibe-Simvastatin Drug Combination
Ezetimibe Simvastatin Drug Combination
Ezetimibe-Simvastatin Combination
Ezetimibe, Simvastatin Drug Combination
Inegy
Vytorin

A pharmaceutical preparation of ezetimibe and simvastatin that is used in the treatment of HYPERCHOLESTEROLEMIA and HYPERLIPIDEMIAS.


Reproductive Tract Infections
Genital Tract Infections

Infections of the genital tract in females or males. They can be caused by endogenous, iatrogenic, or sexually transmitted organisms.


Risk Reduction
Lifestyle Risk Reduction
Risk Reduction Behavior

Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.


Auditory Hyperesthesia
Loudness Perception Disturbances
Recruitment, Loudness
Loudness Recruitment
Phonophobia
Hyperacusia
Hyperacusis

An abnormally disproportionate increase in the sensation of loudness in response to auditory stimuli of normal volume. COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; FACIAL NERVE DISEASES; STAPES SURGERY; and other disorders may be associated with this condition.


A plant genus of the family MALPIGHIACEAE which includes an Amazonian psychoactive plant that contains the beta-carboline harmine and N,N-dimethyltryptamine.


Dideoxyadenosine
2',3'-Dideoxyadenosine
ddA (Antiviral)

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.


Hospital Medical Records Department
Medical Records Department
Medical Records Department, Hospital

Hospital department responsible for the creating, care, storage and retrieval of medical records. It also provides statistical information for the medical and administrative staff.


Gastrotrast Propyliodone Dionosil Propiodone

Radiopaque medium usually in oil; used in bronchography.


Vascular Endothelial Growth Factor Receptor-2

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.


The degeneration and resorption of an OVARIAN FOLLICLE before it reaches maturity and ruptures.


A SYNOVIAL CYST located in the back of the knee, in the popliteal space arising from the semimembranous bursa or the knee joint.


A plant species of the genus GYMNEMA that contains gymnemic acid (triterpene SAPONINS) which affects blood sugar level, and gurmarin protein. The common name of Gurmar should not be confused with Guar (CYAMOPSIS).


Tissue Cages
Diffusion Chambers, Culture
Semi-Permeable Chambers
Semipermeable Chambers
Culture Diffusion Chambers

Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.


Chromatography, Agarose
Agarose Chromatography
Sepharose Chromatography
Chromatography, Sepharose

A method of gel filtration chromatography using agarose, the non-ionic component of agar, for the separation of compounds with molecular weights up to several million.


A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.


Nursing Models
Models, Nursing
Nursing Model
Model, Nursing
Orem Self-Care Model

Theoretical models simulating behavior or activities in nursing, including nursing care, management and economics, theory, assessment, research, and education. Some examples of these models include Orem Self-Care Model, Roy Adaptation Model, and Rogers Life Process Model.


An amino acid that occurs in endogenous proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis.


Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)


Safety, Consumer Product
Product Approval
Consumer Product Safety

The sum total of measures taken and regulatory policies enacted to ensure the safe use of consumer products.


Agnosia for Faces
Facial Recognition Agnosia
Prosopagnosia
Prosopagnosia, Developmental
Prosopagnosia, Acquired

The inability to recognize a familiar face or to learn to recognize new faces. This visual agnosia is most often associated with lesions involving the junctional regions between the temporal and occipital lobes. The majority of cases are associated with bilateral lesions, however unilateral damage to the right occipito-temporal cortex has also been associated with this condition. (From Cortex 1995 Jun;31(2):317-29)


Cholinergic Agonists, Nicotinic
Nicotinic Agonist
Cholinergic Agonist, Nicotinic
Nicotinic Agonists

Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.


Hemorrhagic Septicemia, Viral
Haemorrhagic Septicaemia, Viral

A systemic infection of various salmonid and a few nonsalmonid fishes caused by Viral hemorrhagic septicemia virus (see NOVIRHABDOVIRUS),


Biologic Therapy
Therapy, Biological
Biotherapy
Biological Therapy

Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.


Dye Dilution Technic
Dye Dilution Technique

Method for assessing flow through a system by injection of a known quantity of dye into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)


Technic, Psychological
Technics, Psychological
Psychological Techniques
Psychologic Technics
Techniques, Psychological
Psychologic Techniques
Technique, Psychological
Psychological Technique
Psychological Technic
Psychological Technics
Theoretical Technics
Theoretical Techniques

Methods used in the diagnosis and treatment of behavioral, personality, and mental disorders.


Peptidyl Arginine Deiminase Type 4
Peptidyl Arginine Deiminase Type IV
Protein Arginine Deiminase 4
Peptidylarginine Deiminase V
Protein Arginine Deiminase Type IV
Peptidylarginine Deiminase Type IV
Peptidylarginine Deiminase Type 4
PAD V Enzyme
Peptidylarginine Deiminase IV
PADI4 Protein
Protein-Arginine Deiminase Type IV
Protein Arginine Deiminase Type 4
Protein-Arginine Deiminase Type 4
PADI5 Protein

A histone modification enzyme, which converts both ARGININE and monomethyl-arginine to CITRULLINE. It is one of several protein-arginine deiminase isoenzymes. It is a gene regulator involved in APOPTOSIS and CELL DIFFERENTIATION and a potential therapeutic target for the treatment of a variety of diseases.


(3 beta, 17 alpha)-19-Norpregn-4-en-20-yne-3,17 diol Diacetate

A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).


Eryptosis
Erythrocyte Apoptosis
Suicidal Erythrocyte Death

Suicidal death of ERYTHROCYTES which results in features typical of apoptotic nucleated cells such as cell shrinkage, membrane blebbing, and scrambling of cell membrane to expose membrane PHOSPHATIDYLSERINES, which triggers engulfment and degradation by MACROPHAGES.


Image-Guided Biopsy
Imaging Guided Biopsy

Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.


Integrin beta Subunits
beta Integrins
Integrin beta Chains

Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.


Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.


Methylphenobarbital Methylphenobarbitone Mephobarbital N-Methylphenobarbital Prominal Mebaral

A barbiturate that is metabolized to PHENOBARBITAL. It has been used for similar purposes, especially in EPILEPSY, but there is no evidence mephobarbital offers any advantage over PHENOBARBITAL.


Pressure suits for wear in space or at very low ambient pressures within the atmosphere, designed to permit the wearer to leave the protection of a pressurized cabin. (NASA Thesaurus, 1994)


Muscular Spasm
Spasm, Generalized
Spasm
Spasm, Ciliary Body
Muscle Spasm

An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.


Enterobacteria phage T3
Bacteriophage T3
Phage T3
T3 Phage
Coliphage T3

Bacteriophage in the genus T7-like phages, of the family PODOVIRIDAE, which is very closely related to BACTERIOPHAGE T7.


Urogenital Surgical Procedure
Procedures, Urogenital Surgical
Urogenital Surgical Procedures
Procedure, Urogenital Surgical
Surgical Procedures, Urogenital
Surgical Procedure, Urogenital

Surgery performed on the urinary tract or its organs and on the male or female genitalia.


Forests
Woodland
Forested Areas
Forestlands

An ecosystem dominated by trees and other woody vegetation.


Phosphonoacetate
Fosfonet Sodium
Disodium Phosphonoacetate
Phosphonoacetic Acid
Phosphonacetic Acid

A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.


A transcriptional activator that contains five adjacent CYS2-HIS2 ZINC FINGERS. It functions in the hedgehog signaling pathway and is required for normal embryonic development. Mutations in the GLI2 gene are associated with type 9 HOLOPROSENCEPHALY and type 2 PALLISTER-HALL SYNDROME.


Genes, sry
Sex-Related Gene On Y
Sex-Determining Region Gene On Y
Genes, Sex-Related Y
Gene, sry
Gene, Sex-Determining Region Y

The primary testis-determining gene in mammalians, located on the Y CHROMOSOME. It codes for a high mobility group box transcription factor (TRANSCRIPTION FACTORS) which initiates the development of the TESTES from the embryonic GONADS.


Proteins obtained from species of REPTILES.


Cytotoxic Lymphocyte Maturation Factor
IL-12
Interleukin-12 p70
IL 12
Interleukin 12
Edodekin Alfa
IL12
Natural Killer Cell Stimulatory Factor
Interleukin-12
IL-12 p70

A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.


Cerumenolytic Agents
Cerumenolytic
Cerumen Remover
Wax Solvent

Compounds that disintegrate natural waxy exudates such as EAR WAX.


A 60-kDa extracellular protein of Streptomyces avidinii with four high-affinity biotin binding sites. Unlike AVIDIN, streptavidin has a near neutral isoelectric point and is free of carbohydrate side chains.


The upper rounded extremity of the humerus fitting into the GLENOID CAVITY of the SCAPULA.


Stapedectomy
Stapes Surgery
Surgery, Stapes

Surgery performed in which part of the STAPES, a bone in the middle ear, is removed and a prosthesis is placed to help transmit sound between the middle ear and inner ear.


An arrangement of wires distributing electricity.


Anger Management
Anger Management Therapy
Anger Management Training

System of psychological and/or therapeutic techniques used to control and or reduce the triggers, degrees, and effects of ANGER.


Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth.


Medical and nursing care of patients in the terminal stage of an illness.


Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)


Hydroxyvitamins D
Hydroxycholecalciferol
Hydroxycholecalciferols

Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.


Cowdria ruminantium
Ehrlichia ruminantium

A species of gram-negative bacteria in the family ANAPLASMATACEAE, that causes HEARTWATER DISEASE in ruminants.


Mitochondrial Membrane Transport Proteins

Membrane Transport Proteins, Mitochondrial

Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.