Muramoylpentapeptide Carboxypeptidase
Carboxypeptidase Transpeptidase

Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN.


beta-Heparin
Dermatan Sulfate
Chondroitin Sulfate B

A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)


The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.


The application of mathematical formulas and statistical techniques to the testing and quantifying of economic theories and the solution of economic problems.


Startle Syndrome
Stiff-Man Syndrome
Stiffman Syndrome
Stiff-Baby Syndrome
Hereditary Hyperekplexia
Stiff-Trunk Syndrome
Stiff-Person Syndrome
Congenital Stiff-Person Syndrome
Familial Hyperekplexia
Moersch-Woltmann Syndrome
Congenital Stiff-Man Syndrome

A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)


Photoreceptor Cell Connecting Cilium
Connecting Cilium of Photoreceptor Cell
Connecting Cilium of Photoreceptor
Photoreceptor Connecting Cilium
Photoreceptor Connecting Cilia

The bridge between the inner and the outer segments of a retinal rod or a cone photoreceptor cell. Through it, proteins synthesized in the inner segment are transported to the outer segment.


An EGF family member that is synthesized as a membrane-bound protein that can be cleaved to release an active secreted form. It has a mitogenic effect on EPITHELIAL CELLS.


Protease Inhibitor WAP3
Protease Inhibitor 3, Skin-derived
Elafin
Skin-Derived Antileukoproteinase
Peptidase Inhibitor 3, Skin-derived

A secretory proteinase inhibitory protein that was initially purified from human SKIN. It is found in a variety mucosal secretions and is present at high levels in SPUTUM. Elafin may play a role in the innate immunity (IMMUNITY, INNATE) response of the LUNG.


Papulopustular Rosacea
Acne Rosacea
Phymatous Rosacea
Rosacea
Granulomatous Rosacea
Ocular Rosacea
Erythematotelangiectatic Rosacea


Sodium Hypochlorite (Solution)
Sodium Hypochlorite
Clorox
Antiformin

It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed)


A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.


The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.


Poisoning, Fungus
Fungus Poisoning
Mycotoxicosis

Poisoning caused by the ingestion of mycotoxins (toxins of fungal origin).


Insulinoma
beta-Cell Tumor
Adenoma, beta-Cell
Insuloma

A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.


Spectroscopy, Near-Infrared
Spectrometry, Near-Infrared
NIR Spectroscopy

A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.


This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.


Professionals who are in charge of assessment, planning, facilitation, care coordination, evaluation, and advocacy for options and services to meet a patient’s and family’s comprehensive health needs.


Kennedy Spinal and Bulbar Muscular Atrophy

Spinal And Bulbar Muscular Atrophy, X-Linked 1

X-Linked Spinal and Bulbar Muscular Atrophy

An X-linked recessive form of spinal muscular atrophy. It is due to a mutation of the gene encoding the ANDROGEN RECEPTOR.


Xiphosura
Tachypleus
Horseshoe Crabs
Crabs, Horseshoe
Limulus polyphemus
Limulus

An arthropod subclass (Xiphosura) comprising the North American (Limulus) and Asiatic (Tachypleus) genera of horseshoe crabs.


Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.


Tumor Necrosis Factor Receptor Superfamily, Member 8

A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of the Ki-1 antigen in hematopoietic malignancies make it clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Exostosis, Osteocartilaginous
Exostosis, Cartilaginous
Chondrosteoma
Osteochondroma

A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.


Suppression, Genetic
Genetic Suppression
Suppressor Mutation

Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).


Benzathine Benzylpenicillin
Pendepon
Penduran
Benzathine Benzylpénicilline Panpharma
Penicillin G Benzathine
Benzetacil
Tardocillin
Permapen
Brevicilina
Provipen Benzatina
Pendysin
Bencelin
Debecillin
Benzathine Penicillin
Extencilline
Bicillin L-A
Cepacilina
Penicillin G Benzathine Anhydrous
Bicillin
Peniroger Retard
Penidural

Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.


Postpartum Weight Retention
Pregnancy Weight Gain
Gestational Weight Gain
Maternal Weight Gain

Increase in body weight of the mother during the course of her PREGNANCY.


A large family of phosphatidylinositol phosphate-binding proteins that are involved in mediating intracellular transport and sorting of proteins via a variety of endocytic pathways.


Mephenytoin
Mesantoin
Methyl Phenetoin
Phenantoin
Methoin
Mefenetoin
5-Ethyl-3-Methyl-5-Phenylhydantoin

An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.


Neurons which send impulses peripherally to activate muscles or secretory cells.


Enzymes that catalyze the transfer of N-acetylhexosaminyl groups to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.


Meconium Inhalation
Aspiration, Meconium
Meconium Aspiration
Meconium Aspiration Syndrome

A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.


Total lack of teeth through disease or extraction.


A genus of the family HYLOBATIDAE consisting of nine species. The members of this genus inhabit rain forests in southeast Asia. They are arboreal and differ from other anthropoids in the great length of their arms and very slender bodies and limbs. Their major means of locomotion is by swinging from branch to branch by their arms. Hylobates means dweller in the trees.


A type II keratin that is found associated with the KERATIN-13 in the internal stratified EPITHELIUM. Defects in gene for keratin-4 are a cause of HEREDITARY MUCOSAL LEUKOKERATOSIS.


Integrin alpha(6)beta(1)
alpha6beta1 Integrin
Integrin alpha6beta1
CD49f-CD29
VLA-6
alpha 6 beta 1 Integrin
Platelet Glycoprotein I'c-IIa
Integrin alpha6Abeta1
Integrin alpha6Bbeta1

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.


Gliflozins
SGLT2 Inhibitors
SGLT-2 Inhibitors
Sodium-Glucose Transporter 2 Inhibitors

Compounds that inhibit SODIUM-GLUCOSE TRANSPORTER 2. They lower blood sugar by preventing the reabsorption of glucose by the kidney, and are used in the treatment of TYPE 2 DIABETES MELLITUS.


Eosinophil-Associated Ribonuclease
RNase 3
RNS3 Protein
Serum Eosinophil Cationic Protein
Eosinophil Cationic Protein

One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.


Adenovirus Infections, Human
Infections, Human Adenovirus
Human Adenovirus Infections
Pharyngo-Conjunctival Fever

Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.


Hospital Libraries
Library, Hospital
Libraries, Hospital
Hospital Library

Information centers primarily serving the needs of hospital medical staff and sometimes also providing patient education and other services.


Hydroxypyruvate Reductase
Beta-Hydroxypyruvate Reductase

An enzyme that catalyzes the oxidation of D-glycerate to hydroxypyruvate in the presence of NADP.


HTLV-III Seronegativity
HIV Seronegativity

Immune status consisting of non-production of HIV antibodies, as determined by various serological tests.


A technetium diagnostic aid used in renal function determination.


Herb-Drug Interactions
Herbal Drug Interactions
Drug-Plant Interactions
Adverse Herb-Drug Interactions
Beneficial Herb-Drug Interactions
Plant-Drug Interactions
Drug-Herb Interactions

The adverse or beneficial effect of MEDICINAL HERBS on the activity, metabolism, or toxicity of PHARMACEUTICALS.


CHARGE Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital and Ear Anomalies

Rare disease characterized by COLOBOMA; CHOANAL ATRESIA; and abnormal SEMICIRCULAR CANALS. Mutations in CHD7 protein resulting in disturbed neural crest development are associated with CHARGE Syndrome.


Avoidant Restrictive Food Intake Disorder

An eating or feeding disturbance (e.g., apparent lack of interest in eating or food; avoidance based on the sensory characteristics of food; concern about aversive consequences of eating) as manifested by persistent failure to meet appropriate nutritional and/or energy needs associated with one (or more) of the following: significant weight loss (or failure to achieve expected weight gain or faltering growth in children); significant nutritional deficiency; dependence on enteral feeding or oral nutritional supplements; or marked interference with psychosocial functioning. (from DSM-V)


Abortion Seekers, Refused
Abortion Seekers, Repeated
Abortion Seekers
Abortion Applicants

Individuals requesting induced abortions.


Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome

A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)


Hippocampal Cholinergic Neurostimulating Peptide Precursor

A ubiquitously found basic protein that binds to phosphatidylethanolamine and NUCLEOTIDES. It is an endogenous inhibitor of RAF KINASES and may play a role in regulating SIGNAL TRANSDUCTION. Phosphatidylethanolamine-binding protein is the precursor of hippocampal cholinergic neurostimulating peptide, which is cleaved from the N-terminal region of the protein.


A plant genus of the family Plantaginaceae. Members contain bis-sesquiterpene and iridoid glucosides.


Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.


Dopamine D1 Receptors
Receptors, Dopamine D1
Dopamine-D1 Receptor

A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D1-class receptor genes lack INTRONS, and the receptors stimulate ADENYLYL CYCLASES.


A subclass of segmented worms comprising the tapeworms.


Poisoning, Staphylococcal Food
Staphylococcal Food Poisoning
Food Poisoning, Staphylococcal

Poisoning by staphylococcal toxins present in contaminated food.


A synthetic progestational hormone without significant estrogenic or androgenic properties. It was formerly used as the progestational component in SEQUENTIAL ORAL CONTRACEPTIVE AGENTS .


sPLA(2)-IB
Group IB Secretory Phospholipase A(2)
Phospholipases A2, Group IB
sPLA2-IB
Group IB Phospholipases A2
Group IB Secretory Phospholipase A2

A subclass of group I phospholipases A2 that includes enzymes isolated from PANCREATIC JUICE. Members of this group have specificity for PHOSPHOLIPASE A2 RECEPTORS.


Total Parenteral Nutrition, Home
Home Parenteral Nutrition, Total
Home Total Parenteral Nutrition
Parenteral Nutrition, Home Total
Nutrition, Home Total Parenteral

The at-home administering of nutrients for assimilation and utilization by a patient whose sole source of nutrients is via solutions administered intravenously, subcutaneously or by some other non-alimentary route.


Troponin C1
Troponin C
Troponin C2
Troponin-C

A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.


A subclass of caspases that contain short pro-domain regions. They are activated by the proteolytic action of INITIATOR CASPASES. Once activated they cleave a variety of substrates that cause APOPTOSIS.


Instillation, Rectal
Rectal Drug Administration
Drug Administration, Anal
Drug Administration, Rectal
Rectal Administration
Anal Drug Administration
Administration, Rectal

The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.


Coronary Artery Vasospasm
Coronary Vasospasm

Spasm of the large- or medium-sized coronary arteries.


An analog of benzilylcholine mustard. It is an alkylating nitrogen mustard analog that binds specifically and irreversibly to cholinergic muscarinic receptors and is used as an affinity label to isolate and study the receptors.


The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.


Type IIa Sodium-Phosphate Cotransporter Proteins

Type IIa Sodium-Phosphate Symporter Proteins

Sodium-Phosphate Cotransporter Proteins, Type IIa

An electrogenic sodium-dependent phosphate transporter. It is present primarily in BRUSH BORDER membranes of PROXIMAL RENAL TUBULES.


Artificial Membranes
Membranes, Artificial

Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.


One of the eight permanent teeth, two on either side in each jaw, between the canines (CUSPID) and the molars (MOLAR), serving for grinding and crushing food. The upper have two cusps (bicuspid) but the lower have one to three. (Jablonski, Dictionary of Dentistry, 1992, p822)


Squamous Cell Carcinoma
Carcinoma, Squamous
Carcinoma, Epidermoid
Carcinoma, Squamous Cell
Carcinoma, Planocellular

A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)


Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.


Corneal Topography
Videokeratography
Topography, Corneal

The measurement of curvature and shape of the anterior surface of the cornea using techniques such as keratometry, keratoscopy, photokeratoscopy, profile photography, computer-assisted image processing and videokeratography. This measurement is often applied in the fitting of contact lenses and in diagnosing corneal diseases or corneal changes including keratoconus, which occur after keratotomy and keratoplasty.


Humibid
Breonesin
Glycerol Guaiacolate
Guaifenesin
Guaiphenezine
Guiatuss
My-301
Guaiphenesin
Hytuss
Scott-Tussin
Guaiacol Glyceryl Ether

An expectorant that also has some muscle relaxing action. It is used in many cough preparations.


Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.


Aqueduct of Vestibule
Vestibular Aqueduct

A small bony canal linking the vestibule of the inner ear to the posterior part of the internal surface of the petrous TEMPORAL BONE. It transmits the endolymphatic duct and two small blood vessels.


Sertoli-Leydig Cell Tumor
Androblastoma
Sertoli-Leydig Cell Tumors
Arrhenoblastoma

A sex cord-gonadal stromal tumor consists of LEYDIG CELLS; SERTOLI CELLS; and FIBROBLASTS in varying proportions and degree of differentiation. Most such tumors produce ANDROGENS in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS.


Gamma Spectrophotometry
Spectrometry, Gamma

Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


A plant genus of the family DRYOPTERIDACEAE.


Mullerian Regression Factor
Mullerian Inhibiting Substance
Anti-Mullerian Hormone
Mullerian-Inhibiting Hormone
Mullerian-Inhibitory Substance
Mullerian Inhibiting Hormone
Antimullerian Hormone
Mullerian-Inhibiting Factor
Anti-Mullerian Factor
Anti-Muellerian Hormone

A glycoprotein that causes regression of MULLERIAN DUCTS. It is produced by SERTOLI CELLS of the TESTES. In the absence of this hormone, the Mullerian ducts develop into structures of the female reproductive tract. In males, defects of this hormone result in persistent Mullerian duct, a form of MALE PSEUDOHERMAPHRODITISM.


Talipes Calcaneus
Talipes Calcaneovarus
Talipes
Talipes Varus
Talipedes

Deformity in which the foot is misaligned with respect to the TALUS in the ANKLE JOINT. While mostly congenital, as in CLUBFOOT, acquired deformities are included. Acquired talipedes are often associated with other foot deformities such as SYNDACTYLY and POLYDACTYLY.


Quality of Health Care
Quality of Healthcare
Pharmacy Audit
Quality of Care

The levels of excellence which characterize the health service or health care provided based on accepted standards of quality.


Fat Mass and Obesity Associated (FTO) Protein

A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.


STIs
STDs
Sexually Transmitted Infections
Sexually Transmitted Diseases
Venereal Diseases

Diseases due to or propagated by sexual contact.


Chemotherapy-induced dermal side effects that are associated with the use of various CYTOSTATIC AGENTS. Symptoms range from mild ERYTHEMA and/or PARESTHESIA to severe ulcerative dermatitis with debilitating pain involving typically palmoplantar and intertriginous areas. These cutaneous manifestations are sometimes accompanied by nail anomalies.


C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency
Angioneurotic Edema, Hereditary
Hereditary Angioedema
Hereditary Angioneurotic Edema
Hereditary Angioedemas
Angioedemas, Hereditary
Angioedema, Hereditary

Inherited disorders that are characterized by subcutaneous and submucosal EDEMA in the upper RESPIRATORY TRACT and GASTROINTESTINAL TRACT.


An enzyme of the transferase class that catalyzes the reaction RNA(n+1) and orthophosphate to yield RNA(n) and a nucleoside diphosphate, or the reverse reaction. ADP, IDP, GDP, UDP, and CDP can act as donors in the latter case. (From Dorland, 27th ed) EC 2.7.7.8.


Viral Cell Transformation
Cell Transformation, Viral
Transformation, Viral Cell

An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.


Tracheobronchomegaly
Congenital Tracheobronchomegaly
Mounier-Kuhn Syndrome

A rare and probably congenital condition characterized by great enlargement of the lumen of the trachea and the larger bronchi.


Eating Disorder Diabetes Mellitus Type 1

Eating disorder occurring typically in patients with Diabetes Mellitus, Type 1 who restrict insulin intake in order to lost weight.


In Situ Hybridization, Fluorescent
Fluorescent in Situ Hybridization
In Situ Hybridization, Fluorescence
Hybridization in Situ, Fluorescence
FISH Technic
Hybridization in Situ, Fluorescent
FISH Technique

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.


Root Canal Irrigants
Root Canal Medicaments

Chemicals used mainly to disinfect root canals after pulpectomy and before obturation. The major ones are camphorated monochlorophenol, EDTA, formocresol, hydrogen peroxide, metacresylacetate, and sodium hypochlorite. Root canal irrigants include also rinsing solutions of distilled water, sodium chloride, etc.


Subphrenic Abscess
Abscess, Subphrenic
Subdiaphragmatic Abscess
Abscess, Subdiaphragmatic

Accumulation of purulent EXUDATES beneath the DIAPHRAGM, also known as upper abdominal abscess. It is usually associated with PERITONITIS or postoperative infections.


HLA Class I Histocompatibility Antigen, B-37 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*37 allele family.


Coma Vigil
Akinetic Mutism
Akinetic Autism
Mutism, Akinetic
Coma Vigilans

A syndrome characterized by a silent and inert state without voluntary motor activity despite preserved sensorimotor pathways and vigilance. Bilateral FRONTAL LOBE dysfunction involving the anterior cingulate gyrus and related brain injuries are associated with this condition. This may result in impaired abilities to communicate and initiate motor activities. (From Adams et al., Principles of Neurology, 6th ed, p348; Fortschr Neurol Psychiatr 1995 Feb;63(2):59-67)


Kallikreinogen
Fletcher Factor
Plasma Prokallikrein
Plasma Prokallikrein A
Prekallikrein

A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.


Plasmacytoma
Plasmocytoma
Plasma Cell Tumor

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.


An order of mostly unicellular, microscopic, freshwater algae that have highly symmetrical and varied shapes.


Maxilase
Mégamylase
alpha-1,4-D-Glucanglucanohydrolase
alpha-Amylase
alpha-Amylases
Alpha-Amylase Bayer
Taka-Amylase A

Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.


Moloney murine leukemia virus
Moloney Leukemia Virus

A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.


Plant Somatic Embryogenesis
Plant Somatic Embryogenesis Techniques

The process of embryo initiation in culture from vegetative, non-gametic, sporophytic, or somatic plant cells.


Microvitellogenin
Vitellogenins
Vitellogenin II
Vitellogenin

A protein found in HEMOLYMPH and OVA of adult female MANDUCA, tobacco hornworm moth.


Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)


Family Relationships
Family Relations
Family Dynamics
Family Relationship

Dynamics of interpersonal interaction and developmental processes taking place between and among members of a biological or socially defined family unit.


Diagnosis, Computer-Assisted
Computer-Assisted Diagnosis

Application of computer programs designed to assist the physician in solving a diagnostic problem.


Cyclic P-Oxides
Heterocyclic P-Oxides
Cyclic P Oxides


Glycine Receptor
Receptors, Glycine
Glycine Receptors

Cell surface receptors that bind GLYCINE with high affinity and trigger intracellular changes which influence the behavior of cells. Glycine receptors in the CENTRAL NERVOUS SYSTEM have an intrinsic chloride channel and are usually inhibitory.


Prostaglandin E2 Receptor, EP4 Subtype
Receptors, Prostaglandin E, EP4 Subtype
Prostanoid Receptor EP4
PGE Receptor, EP4 Subtype
Prostaglandin E Receptor 4
Prostaglandin EP4 Receptors
Receptor, Prostaglandin EP4

A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLYL CYCLASES. The receptor may also signal through the activation of PHOSPHATIDYLINOSITOL 3-KINASE.


Adrenergic-Blocking Agents
Adrenolytic Agents
Adrenergic Blockers
Antiadrenergics
Antiadrenergic Agents
Adrenergic Antagonist
Receptor Antagonists, Adrenergic
Adrenolytics
Adrenergic Receptor Antagonists
Adrenergic Antagonists
Adrenolytic Drugs
Adrenergic Receptor Blockaders
Adrenergic Blocker
Adrenergic Blockaders
Anti-Adrenergics

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.


Propoxycaine
Propoxyprocaine
Propoxycaine Hydrochloride

A local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1017)


n-Dodecyl Alcohol
Dodecanol
Dodecyl Alcohol
1-Dodecanol
Lauryl Alcohol

A saturated 12-carbon fatty alcohol obtained from coconut oil fatty acids. It has a floral odor and is used in detergents, lubricating oils, and pharmaceuticals. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)


Scleredema Adultorum of Buschke
Buschke's Scleredema
Scleredema Diabeticorum
Scleredema Diabeticorum of Buschke
Scleredema
Scleredema Adultorum

A diffuse, non-pitting induration of the skin of unknown etiology that occurs most commonly in association with diabetes mellitus, predominantly in females. It typically begins on the face or head and spreads to other areas of the body, sometimes involving noncutaneous tissues. Often it is preceded by any of various infections, notably staphylococcal infections. The condition resolves spontaneously, usually within two years of onset. (From Dorland, 27th ed)


External Fistula
Skin Fistula
Cutaneous Fistula

An abnormal passage or communication leading from an internal organ to the surface of the body.


The rotation of linearly polarized light as it passes through various media.


Intraaortic Balloon Pumping
Pumping, Intra-Aortic Balloon
Intra-Aortic Balloon Pumping

Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.


Monodelphis domestica
Opossums, Short-Tailed
Monodelphis

A genus of short-tailed OPOSSUMS in the family Didelphidae found in South American, chiefly Brazil. They are opossums least well-adapted to arboreal life.


Speciation, Genetics
Genetic Speciation
Cladogenesis

The splitting of an ancestral species into daughter species that coexist in time (King, Dictionary of Genetics, 6th ed). Causal factors may include geographic isolation, HABITAT geometry, migration, REPRODUCTIVE ISOLATION, random GENETIC DRIFT and MUTATION.


Phosphatidylinositol 3-Kinase
Phosphoinositide 3 Kinase
1-Phosphatidylinositol 3-Kinase

A phosphatidylinositol 3-kinase that catalyzes the conversion of 1-phosphatidylinositol into 1-phosphatidylinositol 3-phosphate.


Stx2 protein
Shiga Toxin 2
SLT-II
Shiga-Like Toxin II
Verotoxin 2
SLTII
Shiga Toxin 2, Escherichia coli
Vero Cytotoxin VT2
VT2 Cytotoxin
Shiga Like Toxin II

A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It shares 50-60% homology with SHIGA TOXIN and SHIGA TOXIN 1.


Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.


A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)


Single-Lung Ventilation
One-Lung Ventilation
Lung Separation Techniques


CYP2C9 Inhibitors
P450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C9.


Urogenital Abnormalities
Abnormalities, Urogenital
Genitourinary Abnormalities

Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.


A course of food intake that is high in FATS and low in CARBOHYDRATES. This diet provides sufficient PROTEINS for growth but insufficient amount of carbohydrates for the energy needs of the body. A ketogenic diet generates 80-90% of caloric requirements from fats and the remainder from proteins.


Betamethasone 17-Valerate
Flubenisolonvalerate
Betnovate
Betamethasone Valerate

The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.


Antiinflammatory Agents, Nonsteroidal
Anti Inflammatory Agents, Nonsteroidal
Analgesics, Anti-Inflammatory
Nonsteroidal Anti-Inflammatory Agents
Antiinflammatory Agents, Non Steroidal
NSAIDs
Aspirin-Like Agents
Anti-Inflammatory Agents, Non-Steroidal
Non-Steroidal Anti-Inflammatory Agents

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.


DNA Typing
DNA Fingerprinting
DNA Profiling
Genetic Fingerprinting
DNA Fingerprints

A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.


Bars of HYALINE CARTILAGE extending from the anterior ends of the upper RIBS. They attach to the STERNUM directly or indirectly by connecting to upper costal cartilage that attaches to the STERNUM. Costal cartilages extend the ribs anteriorly and contribute to the enhanced elasticity of the THORACIC WALL.


Distal Kidney Tubule
Kidney Tubules, Distal
Distal Renal Tubule

The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.


Brown Lung Disease
Brown Lung
Byssinosis

A condition of BRONCHOCONSTRICTION resulting from hypersensitive reaction to inhaled dust during the initial processing of cotton, flax, or hemp in the textile industry. Symptoms include wheezing and tightness in the chest.


Sweet food products combining cane or beet sugars with other carbohydrates and chocolate, milk, eggs, and various flavorings. In the United States, candy refers to both sugar- and cocoa-based confections and is differentiated from sweetened baked goods; elsewhere the terms sugar confectionary, chocolate confectionary, and flour confectionary (meaning goods such as cakes and pastries) are used.


Topoisomerase Inhibitors
DNA Topoisomerase Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASES.


Mono-hydroxylated xanthophylls formed from the hydroxylation of BETA-CAROTENE. Isomers include: beta-cryptoxanthin, alpha-cryptoxanthin, and zeinoxanthin. The alpha- and beta-cryptoxanthin are provitamin A precursors.


A class of insecticides that are structurally similar to NICOTINE and have physiologically similar effects as agonists of NICOTINIC ACETYLCHOLINE RECEPTORS, but are less toxic to vertebrates. They are widely used in agriculture.


Allergy
Hypersensitivity
Allergic Reaction

Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.


Fibromatosis, Palmar
Dupuytren's Disease
Dupuytren's Contracture
Dupuytren Contracture

A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.


Chemosympathectomy
Sympathetic Denervation, Chemical
Chemical Sympathetic Denervation
Chemical Sympathectomy
Denervation, Sympathetic, Chemical
Sympathectomy, Chemical

Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.


A Disintegrin And Metalloproteinase With Thrombospondin Motifs 9 Protein

An ADAMTS protease that contains 15 THROMBOSPONDIN (TS) motifs. It cleaves the PROTEOGLYCANS AGGRECAN and VERSICAN and also functions in protein transport from the ENDOPLASMIC RETICULUM to the GOLGI APPARATUS.


Expression of a GENDER IDENTITY inconsistent with, or not culturally-associated with the gender assigned to an individual at birth, combined with the desire to permanently transition to the gender with which they identify.


Late Fetal Mortality
Fetal Mortality
Mortality, Fetal

Number of fetal deaths with stated or presumed gestation of 20 weeks or more in a given population. Late fetal mortality is death after of 28 weeks or more.


Embovin
Combantrin
Pyrantel Embonate
Pyrantel Pamoate
Antiminth

Broad spectrum antinematodal anthelmintic used also in veterinary medicine.


Teleradioisotope Therapy
Teletherapy, Radioisotope
Radioisotope Teletherapy
Therapy, Teleradioisotope

A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.


Vero Cytotoxin-Producing Escherichia coli

Strains of ESCHERICHIA COLI with the ability to produce at least one or more of at least two antigenically distinct, usually bacteriophage-mediated cytotoxins: SHIGA TOXIN 1 and SHIGA TOXIN 2. These bacteria can cause severe disease in humans including bloody DIARRHEA and HEMOLYTIC UREMIC SYNDROME.


Mitochondrial DNA
DNA, Mitochondrial
mtDNA

Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.


TCF7L2 Transcription Factor
Transcription Factor 7-Like 2 Protein
T Cell Factor 4
T-Cell-Specific Transcription Factor 4
T Cell Transcription Factor 4

A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN. Transcription factor 7-like 2 protein plays an important role in the embryogenesis of the PANCREAS and ISLET CELLS.


An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.


Venoms from animals of the phylum Arthropoda. Those most investigated are from scorpions and spiders of the class Arachnidae and from ant, bee, and wasp families of the Insecta order Hymenoptera. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.


Oculocutaneous Albinism with Leukocyte Defect

A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.


Central Nervous System Infection
CNS Infections
Central Nervous System Infections
Infections, Central Nervous System

Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.


Mitochondrial Apoptosis-Inducing Factor
Apoptosis Inducing Factor
AIF Apoptosis Regulatory Protein
Apoptosis-Inducing Factor

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.


Services, School Health
School-Based Services
School Health Services
School-Based Health Services
School Health Promotion
Health Services, School

Preventive health services provided for students. It excludes college or university students.


Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.


Niemann-Pick Disease, Acute Neuronopathic Form

Niemann-Pick Disease, Neuronopathic Type

Niemann-Pick Disease, Acute Neurovisceral Form

The classic infantile form of Niemann-Pick Disease, caused by mutation in SPHINGOMYELIN PHOSPHODIESTERASE. It is characterized by accumulation of SPHINGOMYELINS in the cells of the MONONUCLEAR PHAGOCYTE SYSTEM and other cell throughout the body leading to cell death. Clinical signs include JAUNDICE, hepatosplenomegaly, and severe brain damage.


CXC Chemokine Receptors 3
CXCR3 Receptor
Chemokine (C-C Motif) Receptor 3
CXC Chemokine Receptor 3
CMKBR3 Chemokine Receptors
CD183 Antigens
Receptors, CXCR3
CXCR3 Receptors
Antigens, CD183

CXCR receptors that are expressed on the surface of a number of cell types, including T-LYMPHOCYTES; NK CELLS; DENDRITIC CELLS; and a subset of B-LYMPHOCYTES. The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11.


Handling, Psychology
Handling, Psychological
Handling (Psychology)

Physical manipulation of animals and humans to induce a behavioral or other psychological reaction. In experimental psychology, the animal is handled to induce a stress situation or to study the effects of "gentling" or "mothering".


Translocation, Chromosomal
Chromosomal Translocation
Translocation, Genetic

A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.


A plant genus of the family ASTERACEAE. Oil from the seed (SAFFLOWER OIL) is an important food oil of commerce.


Killer Cell Immunoglobulin-Like Receptor 3DL2

A KIR receptor that has specificity for HLA-A3 ANTIGEN. It is an inhibitory receptor that contains D0, D1, and D2 extracellular immunoglobulin-like domains and a long cytoplasmic tail.


Nodal Signaling Ligands
Nodal Signaling Proteins

Members of the transforming growth factor superfamily that play a role in pattern formation and differentiation during the pregastrulation and GASTRULATION stages of chordate development. Several nodal signaling ligands are specifically involved in the genesis of left-right asymmetry during development. The protein group is named after a critical region of the vertebrate embryo PRIMITIVE STREAK referred to as HENSEN'S NODE.


A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.


HLA Class II Histocompatibility Antigen, DP beta Chains

Transmembrane proteins that form the beta subunits of the HLA-DP antigens.


Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.


Arsphenamine
Sodium Arsenobenzol
Salvarsan
Arsenobenzol

An organoarsenic compound that was commonly used for treating SYPHILIS and other diseases.


An amino sugar formed when glucose non-enzymatically reacts with the N-terminal amino group of proteins. The fructose moiety is derived from glucose by the "classical" Amadori rearrangement.


Closed Head Injuries
Head Injury, Blunt
Head Injury, Nonpenetrating
Head Trauma, Closed
Head Injuries, Closed
Head Injuries, Nonpenetrating
Injuries, Closed Head

Traumatic injuries to the cranium where the integrity of the skull is not compromised and no bone fragments or other objects penetrate the skull and DURA MATER. This frequently results in mechanical injury being transmitted to intracranial structures which may produce TRAUMATIC BRAIN INJURIES, hemorrhage, or CRANIAL NERVE INJURIES. (From Rowland, Merritt's Textbook of Neurology, 9th ed, p417)


Psychoanalytic Interpretation
Psychoanalytical Interpretation
Interpretation, Psychoanalytic

Utilization of Freudian theories to explain various psychologic aspects of art, literature, biographical material, etc.


Ciguatera Fish Poisoning
Ciguatera
Ciguatera Poisoning

Poisoning caused by ingestion of SEAFOOD containing microgram levels of CIGUATOXINS. The poisoning is characterized by gastrointestinal, neurological and cardiovascular disturbances.


Bone Cysts, Aneurysmal
Aneurysmal Bone Cysts

Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.


A plant genus of the family Apiaceae. Commonly called snakeroot but that name is used for many other plants such as ASARUM; ARISTOLOCHIA; and Polygala.


Encephalomyelitis-like Virus, Avian
Avian Encephalomyelitis Virus
Tremovirus A
Avian encephalomyelitis virus 1
Encephalomyelitis Virus, Avian
Avian Encephalomyelitis Viruses
Epidemic Tremor Virus

A tentative species in the genus HEPATOVIRUS infecting primarily young chicks, but also found in turkeys, pheasants, and guinea fowl. It causes a fatal neuronal degeneration and is transmitted by mechanical contact.


Projections and Predictions
Forecasting
Future
Futurology

The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.


The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.


Diverticulosis, Colonic
Colonic Diverticulosis

A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.


Depilation
Epilation
Hair Removal
Electrolytic Depilation

Methods used to remove unwanted facial and body hair.


Colonoscopy, Virtual
CT Colonography
Virtual Colonoscopy
Colonography, Computed Tomographic
Computed Tomographic Colonography

A non-invasive imaging method that uses computed tomographic data combined with specialized imaging software to examine the colon.


Dihydropteridine Reductase
6,7-Dihydropteridine Reductase

An enzyme that catalyzes the reduction of 6,7-dihydropteridine to 5,6,7,8-tetrahydropteridine in the presence of NADP+. Defects in the enzyme are a cause of PHENYLKETONURIA II. Formerly listed as EC 1.6.99.7.


Pachymeningitis, Fungal
Fungal Meningitis
Meningitis, Fungal

Meningitis caused by fungal agents which may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.


ATP Binding Cassette Transporter, Subfamily B, Member 2

ATP Binding Cassette Transporter, Sub-Family B, Member 2

Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR-TAP)

ATP-Binding Cassette Sub-Family B Member 2

An ATP-binding cassette, sub-family B protein (ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B) that functions in the transport of ANTIGENS from the CYTOPLASM to the ENDOPLASMIC RETICULUM for association with HISTOCOMPATIBILITY ANTIGENS CLASS I peptides. It also acts as a molecular scaffold for the final stage of MHC class I PROTEIN FOLDING.


Self Control
Self-Control
Self-Regulation
Self Regulation

An individual's ability to manage and monitor their emotions, behaviors, and desires in the face of external demands in order to function in society.


Vestibular Hair Cells
Hair Cells, Vestibular

Sensory cells in the acoustic maculae with their apical STEREOCILIA embedded in a gelatinous OTOLITHIC MEMBRANE. These hair cells are stimulated by the movement of otolithic membrane, and impulses are transmitted via the VESTIBULAR NERVE to the BRAIN STEM. Hair cells in the saccule and those in the utricle sense linear acceleration in vertical and horizontal directions, respectively.


AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.


Branchial Cyst
Branchial Cleft Cyst
Branchioma
Branchial Cysts

A tumor derived from branchial epithelium or branchial rests. (Dorland, 27th ed)


Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome

A highly evolutionarily conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc subunits 6, 7, and 8, have been shown to mediate protein-protein interactions, suggesting that Apc3 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to co-activators and APC-C inhibitors.


A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.


Inclusion Bodies, Intranuclear
Nuclear Inclusion Bodies
Intranuclear Inclusion Bodies
Intranuclear Inclusions
Nuclear Inclusions

Circumscribed masses of foreign or metabolically inactive materials, within the CELL NUCLEUS. Some are VIRAL INCLUSION BODIES.


Follicle Stimulating Hormone-Releasing Hormone Receptors

Luteinizing Hormone Releasing Hormone Receptors

Luteinizing Hormone Releasing-Hormone Receptor

Receptors with a 6-kDa protein on the surfaces of cells that secrete LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE, usually in the adenohypophysis. LUTEINIZING HORMONE-RELEASING HORMONE binds to these receptors, is endocytosed with the receptor and, in the cell, triggers the release of LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE by the cell. These receptors are also found in rat gonads. INHIBINS prevent the binding of GnRH to its receptors.


Cochleovestibular Nerve
Vestibulocochlear Nerve
Cranial Nerve VIII
Statoacoustic Nerve
Eighth Cranial Nerve

The 8th cranial nerve. The vestibulocochlear nerve has a cochlear part (COCHLEAR NERVE) which is concerned with hearing and a vestibular part (VESTIBULAR NERVE) which mediates the sense of balance and head position. The fibers of the cochlear nerve originate from neurons of the SPIRAL GANGLION and project to the cochlear nuclei (COCHLEAR NUCLEUS). The fibers of the vestibular nerve arise from neurons of Scarpa's ganglion and project to the VESTIBULAR NUCLEI.


Erythrocyte Number
Erythrocyte Count
Blood Cell Count, Red
Red Blood Cell Count

The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.


SUMO Protein
PIC1 Protein
UBL1 Protein
Sentrin 1
Ubiquitin-like 1 Gene Product
PIC 1 Protein
SMT3C Protein
SUMO-1 Protein
Gap-modifying Protein 1
Sentrin
PML-Interacting Clone Protein
Protein GMP1

A 1.5-kDa small ubiquitin-related modifier protein that can covalently bind via an isopeptide link to a number of cellular proteins. It may play a role in intracellular protein transport and a number of other cellular processes.


Coproporphyria, Hereditary
Coproporphyrinogen Oxidase Deficiency
Hereditary Coproporphyria

An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.


The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.


Education, Premedical
Medical Propedeutics
Premedical Education

Introductory courses leading to an advance study in medicine.


The third tooth to the left and to the right of the midline of either jaw, situated between the second INCISOR and the premolar teeth (BICUSPID). (Jablonski, Dictionary of Dentistry, 1992, p817)


Economic Development
Development, Economic
Economic Growth

Increase in the level of production of goods and services.


Receptors, IL-10
Receptors, Interleukin-10
IL-10 Receptor
Receptor, Interleukin-10
Interleukin-10 Receptor
Interleukin-10 Receptors

Cell surface receptors for INTERLEUKIN-10. They exist as a tetramer of two alpha chains (INTERLEUKIN-10 RECEPTOR ALPHA CHAIN) and two beta chains (INTERLEUKIN-10 RECEPTOR, BETA CHAIN). Signaling from interleukin-10 receptors occurs through their interaction with JANUS KINASES.


Pronase
Pronase E
Pronase P
Protease XIV

A proteolytic enzyme obtained from Streptomyces griseus.


Encephalopathy, Traumatic
Traumatic Encephalopathy
TBI (Traumatic Brain Injury)
Injury, Brain, Traumatic
Traumatic Brain Injury
TBIs (Traumatic Brain Injuries)
Brain Injuries, Traumatic
Trauma, Brain

A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.


Citraconic Anhydrides
Methylmaleic Anhydrides


A family of hepatotropic DNA viruses which contains double-stranded DNA genomes and causes hepatitis in humans and animals. There are two genera: AVIHEPADNAVIRUS and ORTHOHEPADNAVIRUS. Hepadnaviruses include HEPATITIS B VIRUS, duck hepatitis B virus (HEPATITIS B VIRUS, DUCK), heron hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis B virus (HEPATITIS B VIRUS, WOODCHUCK).


Economic aspects of the nursing profession.


A genus of the Proteidae family with five recognized species, which inhabit the Atlantic and Gulf drainages.


Mitogen-Activated Protein Kinase 12
Extracellular Signal-Regulated Kinase 6
p38gamma MAP Kinase
SAP Kinase-3
Stress-Activated Protein Kinase-3
SAPK3
MAPK12 Mitogen-Activated Protein Kinase
ERK6 Protein
SAP Kinase 3

A 38-kDa mitogen-activated protein kinase found primarily in SKELETAL MUSCLE.


Chlorinated Steroids
Steroids, Chlorinated

Steroids which are substituted with one or more chlorine atoms in any position.


Order of winged insects also known as beetles comprising over 350,000 species in 150 families. They possess hard bodies with mouthparts adapted for chewing.


Somnography
Polysomnography
Monitoring, Sleep

Simultaneous and continuous monitoring of several parameters during sleep to study normal and abnormal sleep. The study includes monitoring of brain waves, to assess sleep stages, and other physiological variables such as breathing, eye movements, and blood oxygen levels which exhibit a disrupted pattern with sleep disturbances.


Simian Immunodeficiency Viruses
SIV (Simian immunodeficiency virus)
Simian Immunodeficiency Virus
Immunodeficiency Viruses, Simian

Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.


Capsule, Bacterial
Capsules, Bacterial
Bacterial Capsule
Bacterial Capsules

An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.


Temporary shelter provided in response to a major disaster or emergency.


T-Cell-Specific Surface Glycoprotein CD28

Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.


Opportunistic Infections, HIV-Related
HIV-Related Opportunistic Infections
Opportunistic Infections, AIDS-Related
AIDS-Related Opportunistic Infections

Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.


A disease or state in which death is possible or imminent.


Colitis, Collagenous
Collagenous Colitis

A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show larger-than-normal band of subepithelial COLLAGEN.


Receptors, Guanylate Cyclase-Coupled
Guanylyl Cyclase-Linked Receptors
Guanylyl Cyclase Receptors
Guanylate Cyclase-Coupled Receptors

A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or are closely coupled to specific guanylate cyclases within the cell.


Hereditary Spinal Sclerosis
Sclerosis, Hereditary Spinal
Friedreich's Ataxia
Friedreich Hereditary Spinal Ataxia
Friedreich Ataxia
Friedreich's Disease
Friedreich's Familial Ataxia
Hereditary Spinal Ataxia, Friedreich
Friedreich Hereditary Ataxia
Friedreich's Hereditary Spinal Ataxia
Friedreich Familial Ataxia
Friedreich Disease
Friedreich Spinocerebellar Ataxia
Hereditary Spinal Ataxia, Friedreich's
Friedreich's Hereditary Ataxia

An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)


A narrow cleft inferior to the CORPUS CALLOSUM, within the DIENCEPHALON, between the paired thalami. Its floor is formed by the HYPOTHALAMUS, its anterior wall by the lamina terminalis, and its roof by EPENDYMA. It communicates with the FOURTH VENTRICLE by the CEREBRAL AQUEDUCT, and with the LATERAL VENTRICLES by the interventricular foramina.


A monocot family within the order Liliales.


Clinical Pathways
Critical Paths
Critical Pathways
Clinical Paths

Schedules of medical and nursing procedures, including diagnostic tests, medications, and consultations designed to effect an efficient, coordinated program of treatment. (From Mosby's Medical, Nursing & Allied Health Dictionary, 4th ed)


Macacus speciosus
M. arctoides
Bear Macaque
M. brunneus
Stump-Tailed Macaque
M. ursinus
Brown Stump-tailed Macaque
Macacus brunneus
M. speciosus
Macacus ursinus
Macaca arctoides

A species of the genus MACACA inhabiting India, China, and other parts of southern Asia. The species is characterized by its thick brown fur covering most of its body except the face and short tail.


One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.


INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.


Eardrum Perforation
Tympanic Membrane Rupture
Tympanic Membrane Perforation

A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.


The field of dentistry involved in procedures for designing and constructing dental appliances. It includes also the application of any technology to the field of dentistry.


Exoproteases Exopeptidases Exoprotease Exopeptidase

A sub-class of PEPTIDE HYDROLASES that act only near the ends of polypeptide chains.


ets Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ets
c-ets Proto-Oncogene Proteins
Proto-Oncogene Protein ets
c-ets Protein
ets Transcription Factors

A family of transcription factors that share a unique DNA-binding domain. The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS.


Environment, Extraterrestrial
Space (Astronomy)
Extraterrestrial Environment

The environment outside the earth or its atmosphere. The environment may refer to a closed cabin (such as a space shuttle or space station) or to space itself, the moon, or other planets.


Ear Canal
External Acoustic Meatus
Auditory Canal, External
External Auditory Canal
External Ear Canal
External Acoustic Canal

The narrow passage way that conducts the sound collected by the EAR AURICLE to the TYMPANIC MEMBRANE.


Carcinogen Tests
Carcinogenesis Tests
Carcinogenic Potency Tests
Tumorigenicity Tests
Carcinogenicity Tests
Carcinogenic Activity Tests

Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.


Folie a Deux
Folie a Trois
Paranoid Disorder, Shared
Shared Psychotic Disorder
Shared Paranoid Disorder

A condition in which closely related persons, usually in the same family, share the same delusions.


DNA-Dependent Protein Serine-Threonine Kinase

A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.


Prosthesis-Related Infections
Infections, Prosthesis-Related

Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).


WD40 Repeat
beta-Transducin Repeats
WD40 Repeats
WD40 Motif
WD Repeats

Protein interaction motifs of approximately 40 amino acids that usually terminate in TRYPTOPHAN and ASPARTIC ACID. They form characteristic beta-propeller structures and occur in many eukaryotic proteins that function in a variety of cellular processes. Proteins that contain WD40 repeats often function as assembly platforms for MULTIPROTEIN COMPLEXES.


Bone Morphogenetic Proteins
Bone Morphogenetic Protein

Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.


Prostatropin
FGF-2
HBGF-2
Class II Heparin-Binding Growth Factor
Prostate Epithelial Cell Growth Factor
Cartilage-Derived Growth Factor
Fibroblast Growth Factor 2
Fibroblast Growth Factor, Basic
Heparin-Binding Growth Factor Class II
FGF2
Fibroblast Growth Factor-2
Basic Fibroblast Growth Factor

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).


Integrase Inhibitors
Inhibitors, Integrase

Compounds which inhibit or antagonize biosynthesis or actions of integrase.


An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. It plays a role in the degradation of VALINE; LEUCINE; and ISOLEUCINE.


Group Practice, Dental
Dental Group Practice
Group Practices, Dental
Practices, Dental Group
Dental Group Practices
Practice, Dental Group

Any group of three or more full-time dentists, organized in a legally recognized entity for the provision of dental care, sharing space, equipment, personnel and records for both patient care and business management, and who have a predetermined arrangement for the distribution of income.


Practice Patterns, Nurses'
Nurse's Practice Patterns
Nurse-Led Clinics

Patterns of practice in nursing related to provision of services including diagnosis and treatment.


Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.


Micronucleus, Germline
Germline Micronucleus
Germinal Micronucleus
Micronuclei, Germline

The smaller, reproductive, transcriptionally inert nucleus in the cells of ciliate protozoans, as distinguished from the larger, vegetative, transcriptionally active MACRONUCLEUS. Micronuclei participate in MEIOSIS and autogamy during GENETIC CONJUGATION.


A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.


Children of Impaired Parents
Impaired Parents' Children
Offspring of Impaired Parents
Child of Impaired Parents

Child with one or more parents afflicted by a physical or mental disorder.


Spontaneous verbalization of whatever comes to mind.


A carpal bone with a rounded head located between the TRAPEZOID BONE and the HAMATE BONE.


Secretogogue Secretagogues Secretogogues Secretagogue

Substances that stimulate the secretion of another substance.


Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.


Sensing of noxious mechanical, thermal or chemical stimuli by NOCICEPTORS. It is the sensory component of visceral and tissue pain (NOCICEPTIVE PAIN).


Research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.


Diastasis Symphysis Pubis
Pubic Symphysis Diastasis
Symphysis Pubis Diastasis

Separation of the PUBIC SYMPHYSIS. It is an uncommon complication of CHILDBIRTH causing postpartum PAIN, but it can also arise from other causes.


Guidelines for Health Planning
Health Planning Guidelines
Recommendations, Health Planning

Recommendations for directing health planning functions and policies. These may be mandated by PL93-641 and issued by the Department of Health and Human Services for use by state and local planning agencies.


Russo-Japanese War, 1904-1905
Russian-Japanese War

Conflict from 1904 through 1905 between Russia and Japan regarding Manchuria and Korea.


Compounds also known as tetrahydropyridines with general molecular formula (CH2)4NH.


A plant species of the genus CITRUS, family RUTACEAE that provides the familiar orange fruit which is also a source of orange oil.


Histone Marks
Histone Code
Histone Modifications

The specific patterns of changes made to HISTONES, that are involved in assembly, maintenance, and alteration of chromatin structural states (such as EUCHROMATIN and HETEROCHROMATIN). The changes are made by various histone modification processes that include ACETYLATION; METHYLATION; PHOSPHORYLATION; and UBIQUITINATION.


Follicle-Stimulating Hormone, alpha Subunit

Thyroid-Stimulating Hormone, alpha Subunit

Pituitary Glycoprotein Hormone, alpha Subunit

Follicle Stimulating Hormone, alpha Subunit

Common alpha Subunit Glycoprotein Hormones

Glycoprotein Hormones, alpha Polypeptide

The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.


Programs of disease surveillance, generally within health care facilities, designed to investigate, prevent, and control the spread of infections and their causative microorganisms.


Acute Cholecystitis
Cholecystitis, Acute

Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.


Relation, Centric
Dental Centric Relation
Centric Relation, Dental
Centric Relation
Relation, Dental Centric

The location of the maxillary and the mandibular condyles when they are in their most posterior and superior positions in their fossae of the temporomandibular joint.


Genes, Neoplasm
Neoplasm Genes
Cancer Genes

Genes whose abnormal expression, or MUTATION are associated with the development, growth, or progression of NEOPLASMS.


Freshly frozen PLASMA after the removal of PLATELETS.


Furazolidine Furazol Furoxone Furazolidone Nifurazolidone

A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)


Sinusitis, Ethmoid
Ethmoidal Sinusitis
Ethmoid Sinusitis

Inflammation of the NASAL MUCOSA in the ETHMOID SINUS. It may present itself as an acute (infectious) or chronic (allergic) condition.


Gonadal Steroid Hormones
Sex Hormones
Sex Steroid Hormones

Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.


Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase

A phosphoric diester hydrolase with specificity for the cleavage of GLYCEROL from 1-(sn-glycero-3-phospho)-1D-myo-inositol. It also has specificity for hydrolysis of the cyclic phosphate bond in inositol 1,2-cyclic phosphate


Acid Sensing Ion Channel Inhibitors
Acid Sensing Ion Channel Blockers
Proton-Gated Sodium Channel Blockers
ASIC Inhibitors
ASIC Channel Blockers
ASIC Blockers
ASIC Channel Antagonists

A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS.


NES Peptide
Nuclear Export Signal Peptide
Nuclear Export Signal
Nuclear Export Signals

Specific amino acid sequences present in the primary amino acid sequence of proteins which mediate their export from the CELL NUCLEUS. They are rich in hydrophobic residues, such as LEUCINE and ISOLEUCINE.


Quinol-Nitrate Oxidoreductase
Nitrate Reductase
Respiratory Nitrate Reductase

An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contains IRON and MOLYBDENUM.


Models, Surgical
Models, Anatomical
Anatomic Models
Moulages
Models, Anatomic

Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study.


Odontogenic Dysplasia
Ghost Teeth
Ghost Tooth
Odontodysplasia
Odontogenesis Imperfecta

A localized arrested tooth development which appears to involve most commonly the anterior teeth, usually on one side of the midline, most often the maxillary central and lateral incisors. Roentgenographically, the teeth have a ghostlike appearance. Calcification and bits of prismatic enamel may be found in the pulp and the enamel is thin and absent in part. (Jablonski, Illustrated Dictionary of Dentistry, 1982)


Instruments for the visual examination of interior structures related to NEUROSURGICAL PROCEDURES. There are two broad categories of neuroendoscopes, the rigid scope and the flexible scope, for various types of procedures.


Technetium Tc 99m Methylenediphosphonate

A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.


Hematoporphyrin Photoradiation
Hematoporphyrin Photochemotherapy
Photochemotherapy, Hematoporphyrin
Photoradiation, Hematoporphyrin

Photochemotherapy using visible light, usually red, topically or delivered locally by fiberoptic probe to tissues sensitized with hematoporphyrins.


Audiometry, Electroencephalic Response
Electrocochleography
Evoked Response Audiometry
Audiometry, Evoked Response

A form of electrophysiologic audiometry in which an analog computer is included in the circuit to average out ongoing or spontaneous brain wave activity. A characteristic pattern of response to a sound stimulus may then become evident. Evoked response audiometry is known also as electric response audiometry.


Persons who are enrolled in research studies or who are otherwise the subjects of research.


The ejection of gas or air through the mouth from the stomach.


An abnormal opening or fissure between two adjacent teeth.


Watery fluid produced in the serous and visceral pericardium surrounding the surface of the HEART.


C 5b-9
C5b-8-poly-C9
Complement Membrane Attack Complex
Complement Complex C5b-9
Terminal Complement Complex
Cytolytic Terminal Complement Complex
C5b-9
Membrane Attack Complex

A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.


HAC (Chromosome)
HACs (Chromosomes)
Human Artificial Chromosomes
Chromosomes, Artificial, Human
Artificial Chromosomes, Human
Chromosomes, Human Artificial

DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful replication, propagation to and maintainance in progeny human cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.


Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)


Nurse Training Schools
Schools, Nurse Training
Nursing Schools
Schools, Nursing

Educational institutions for individuals specializing in the field of nursing.


Volunteer, Hospital
Volunteers, Hospital
Hospital Volunteers
Hospital Volunteer

Individuals who donate their services to the hospital.


Library Associations
Associations, Library

Organizations of persons and institutions associated with a type of library or region.


Sabril
Vigabatrin
Sabrilex
gamma-Vinyl-GABA
gamma-Vinyl-gamma-Aminobutyric Acid

An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA-AMINOBUTYRIC ACID and is used as an anticonvulsant. (From Martindale The Extra Pharmacopoeia, 31st ed)


Face Perception
Identity Recognition
Facial Recognition

Identification of another individual by their facial and other bodily features.


A method of detection of the number of cells in a sample secreting a specific molecule. With this method, a population of cells are plated over top of the immunosorbent substrate that captures the secreted molecules.


Biology, Radiation
Radiation Biology
Radiobiology

Study of the scientific principles, mechanisms, and effects of the interaction of ionizing radiation with living matter. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Leptomeningeal Carcinomatosis
Meningeal Carcinomatosis
Carcinomatous Meningitis

Primary or secondary neoplasm in the ARACHNOID or SUBARACHNOID SPACE. It appears as a diffuse fibrotic thickening of the MENINGES associated with variable degrees of inflammation.


Models, Statistical
Model, Statistical
Statistical Model
Two-Parameter Models
Statistical Models
Models, Binomial
Probabilistic Models
Models, Polynomial

Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.


Cuemid
Questran
Quantalan
Colestyramine
Cholestyramine Resin
MK-135
Colestyramin
Cholestyramine

A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.


Relationship, Immunologic Dose-Response
Immunologic Dose-Response Relationship
Dose-Response Relationship, Immunologic

A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.


Health Service Area
Service Area, Health
Health Catchment Area
Catchment Area, Health

A geographic area defined and served by a health program or institution.


The loosestrife plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. Members are mainly herbs and many of them contain ALKALOIDS.


Inotropism
Muscle Contraction
Muscular Contraction

The quality of affecting MUSCLE contractility, positively or negatively.


Streptococcus faecium
Enterococcus faecium

A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.


Commonwealth of Independent States
CIS Nations

An economic union of Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine.


Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.


An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.


Medical Receptionist
Receptionists, Medical
Medical Receptionists
Receptionist, Medical

Individuals who receive patients in a medical office.


Hemophthalmos
Hemorrhage, Eye
Eye Hemorrhage

Intraocular hemorrhage from the vessels of various tissues of the eye.


Sternocostoclavicular Hyperostosis
Hyperostosis, Sternocostoclavicular

A rare, benign rheumatologic disorder or syndrome characterized by hyperostosis and soft tissue ossification between the clavicles and the anterior part of the upper ribs. It is often associated with the dermatologic disorder palmoplantar pustulosis, particularly in Japan. Careful diagnosis is required to distinguish it from psoriatic arthritis, OSTEITIS DEFORMANS, and other diseases. Spondylitis of pustulosis palmaris et plantaris is one of the possible causes; also, evidence suggests one origin may be bone infection. Bone imaging is especially useful for diagnosis. It was originally described by Sonozaki in 1974.


A plant genus of the family LAMIACEAE used to flavor food.


Anthropology, Cultural
Cultural Anthropology
Material Culture
Ethnography

Study of objects made or used by people, especially the folk artifacts produced by traditional methods, as well as techniques of their production.


Shoulder Joint
Glenoid Labrum
Glenohumeral Joint

The articulation between the head of the HUMERUS and the glenoid cavity of the SCAPULA.


A field of anatomical pathology in which living tissue is surgically removed for the purpose of diagnosis and treatment.


Phenethylazocine
Phenazocine Hydrobromide
Narphen
Phenbenzorphan
Phenazocine

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)


Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS).


Labor Presentation, Breech
Frank Breech Presentation
Presentation, Breech
Breech Presentation
Fetal Presentation, Breech
Complete Breech
Incomplete Breech

A malpresentation of the FETUS at near term or during OBSTETRIC LABOR with the fetal cephalic pole in the fundus of the UTERUS. There are three types of breech: the complete breech with flexed hips and knees; the incomplete breech with one or both hips partially or fully extended; the frank breech with flexed hips and extended knees.


alpha5 Integrin
Platelet Glycoprotein Ic
VLA-5 alpha Chain
Integrin alpha5
CD49e Antigen
alpha(5) Integrin
Integrin alphaF
Antigens, CD49e
CD49e Antigens

This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.


Pharmaceutic Preservative
Preservatives, Pharmaceutic
Pharmaceutic Aids (Preservatives)
Preservative, Pharmaceutical
Pharmaceutical Preservative
Pharmaceutical Preservatives
Preservatives, Pharmaceutical
Pharmaceutic Preservatives
Preservative, Pharmaceutic

Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.


Cadherin-Related Proteins
CDHR Proteins
Cadherin Related Proteins

Membrane proteins that contain at least two typical consecutive CADHERIN motifs but typically more than cadherin or protocadherin proteins. Their overall domain organization also differs from those of cadherins and protocadherins, and contains different and unique cytoplasmic domains.


Acute Retinal Necrosis
Retinal Necrosis Syndrome, Acute

Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome.


Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)


A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Gram Negative Oxygenic Photosynthetic Bacteria

Gram-Negative Oxygenic Photosynthetic Bacteria

Widely distributed unicellular or multicellular bacteria. The CYANOBACTERIA use chlorophyll a and phycobilins for oxygenic photosynthesis while genera in the Prochlorales use both chlorophyll a and b but not phycobilins.


Steroid Hydroxylases
Steroid Monooxygenases

Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.


Inosinate Phosphatase
Thymidine Phosphatase
IMP Phosphatase
Uridylate 5'-Nucleotidase
5'-AMP Nucleotidase
CD73 Antigens
Cytidylate Phosphatase
IMP Nucleotidase
Antigens, CD73
IMPase
Adenylate Phosphatase
5'-Nucleotidase
Pyrimidine 5'-Nucleotidase
Antigen, CD73
5'-Nucleotidase Phosphoribolase
AMP Phosphatase
Ecto-5'-Nucleotidase

A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.


Inclusion Disease
Cytomegalic Inclusion Disease
Cytomegalovirus Infections
Infections, Cytomegalovirus
Salivary Gland Virus Disease

Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.


An essential branched-chain amino acid important for hemoglobin formation.


Hydroxyamphetamin
para-Hydroxyamphetamine
Paredrine
Hydroxyamphetamine
p-Hydroxyamphetamine
Methyltyramine
Hydroxyamfetamine
Oxyamphetamine
Norpholedrin
Hydroxyamphetamine Hydrobromide
Hydroxyphenylisopropylamine

Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine.


Ganglia, Sensory
Sensory Ganglia
Ganglion, Sensory

Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.


A primitive form of vertebrate kidney that is found in adults of some primitive FISHES and in the embryos of more advanced fishes. In some species of fishes it contains phagocytic cells and is also a major site of HEMATOPOIESIS, analogous to the mammalian BONE MARROW.


N-Succinyl Diaminopimelic Acid Aminotransferase

A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer amino group from N-succinyl-L-2,6-diaminoheptanedioate to 2-oxoglutarate in order to generate N-succinyl-2-L-amino-6-oxoheptanedioate and L-GLUTAMATE, respectively.


beta-Chemokines
CC Chemokines
C-C Chemokines
Chemokines, CC

Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.


Congenital Nystagmus
Nystagmus, Congenital

Nystagmus present at birth or caused by lesions sustained in utero or at the time of birth. It is usually pendular, and is associated with ALBINISM and conditions characterized by early loss of central vision. Inheritance patterns may be X-linked, autosomal dominant, or recessive. (Adams et al., Principles of Neurology, 6th ed, p275)


The carbohydrate-rich zone on the cell surface. This zone can be visualized by a variety of stains as well as by its affinity for lectins. Although most of the carbohydrate is attached to intrinsic plasma membrane molecules, the glycocalyx usually also contains both glycoproteins and proteoglycans that have been secreted into the extracellular space and then adsorbed onto the cell surface. (Alberts et al., Molecular Biology of the Cell, 3d ed, p502)


ATP Binding Cassette Transporter, Subfamily B, Member 11

ATP Binding Cassette Subfamily B Member 11

ATP Binding Cassette Transporter, Sub-Family B, Member 11

ATP-binding cassette, subfamily B, protein (P-glycoproteins) that functions in the ATP-dependent secretion of BILE SALTS into the BILE CANALICULI of HEPATOCYTES. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis 2 (see CHOLESTASIS, INTRAHEPATIC).


Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular. Acute and chronic gouty arthritis are associated with accumulation of MONOSODIUM URATE in and around affected joints.


Whole Body Screening
Whole Body Scan
Whole Body Imaging
Whole Body Scanning

The creation of a visual display of the inside of the entire body of a human or animal for the purposes of diagnostic evaluation. This is most commonly achieved by using MAGNETIC RESONANCE IMAGING; or POSITRON EMISSION TOMOGRAPHY.


Gene Rearrangement, alpha-Chain T Cell Antigen Receptor

T-Lymphocyte Antigen Receptor alpha-Chain Gene Rearrangement

T Lymphocyte alpha-Chain Gene Rearrangement

Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor

T-Cell Antigen Receptor alpha-Chain Gene Rearrangement

Ordered rearrangement of T-cell variable gene regions coding for the alpha-chain of antigen receptors.


Enterococcus hirae
Streptococcus faecalis ATCC 9790
Streptococcus faecium ATCC 9790

A species of Enterococcus that occurs in the GASTROINTESTINAL TRACT of birds and mammals, and to a lesser extent humans. Some strains cause diseases including DIARRHEA; BACTEREMIA; and ENDOCARDITIS  in humans and animals.


Statistical Data Interpretation
Interpretation, Statistical Data
Data Analysis, Statistical
Statistical Data Analysis
Data Interpretations, Statistical
Data Interpretation, Statistical

Application of statistical procedures to analyze specific observed or assumed facts from a particular study.


The longest of all venomous snakes and largest Elapid. It is not a member of the Naja genus, although its hood resembles the hood of Naja species. Its bite can deliver large quantities of neurotoxic and cardiotoxic venom, consisting primarily of ALPHA-NEUROTOXINS. King cobras are indigenous to forests of India and Southeast Asia.


A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site.


Insulin-Like Growth Factor Binding Protein 4

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.


Acid Etching, Dental
Dental Acid Etching
Etching, Dental Acid

Preparation of TOOTH surfaces and DENTAL MATERIALS with etching agents, usually phosphoric acid, to roughen the surface to increase adhesion or osteointegration.


An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia. This enzyme is specific for arginine biosynthesis or the urea cycle. Absence or lack of this enzyme may cause CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY DISEASE. EC 6.3.4.16.


Glucosyl Ceramides
Glucosylceramides
Glucocerebrosides

Cerebrosides which contain as their polar head group a glucose moiety bound in glycosidic linkage to the hydroxyl group of ceramides. Their accumulation in tissue, due to a defect in beta-glucosidase, is the cause of Gaucher's disease.


Hallux Duplication, Postaxial Polydactyly, and Absence of Corpus Callosum

Autosomal recessive syndrome characterized by hypogenesis or agenesis of CORPUS CALLOSUM. Clinical features include MENTAL RETARDATION; CRANIOFACIAL ABNORMALITIES; digital malformations, and growth retardation.


Persons trained in PHYSICAL THERAPY SPECIALTY to make use of PHYSICAL THERAPY MODALITIES to prevent, correct, and alleviate movement dysfunction.


Abnormal placentation in which the PLACENTA implants in the lower segment of the UTERUS (the zone of dilation) and may cover part or all of the opening of the CERVIX. It is often associated with serious antepartum bleeding and PREMATURE LABOR.


A metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.


Plantaginaceae
Speedwell Family
Globularia
Stemodia

A plant family of order Lamiales. The Plantago genus is best known. Lesser known members include Hippuris, Littorella and Callitriche.


A technique utilizing a laser coupled to a catheter which is used in the dilatation of occluded blood vessels. This includes laser thermal angioplasty where the laser energy heats up a metal tip, and direct laser angioplasty where the laser energy directly ablates the occlusion. One form of the latter approach uses an EXCIMER LASER which creates microscopically precise cuts without thermal injury. When laser angioplasty is performed in combination with balloon angioplasty it is called laser-assisted balloon angioplasty (ANGIOPLASTY, BALLOON, LASER-ASSISTED).


Specialized NEURONS that produce hormones, such as NEUROPEPTIDES or BIOGENIC AMINES. They generally are in the NERVOUS SYSTEM, such as HYPOTHALAMUS, but can be found in other organs or systems. These neurons contain dense neurosecretory granules and PROPROTEIN CONVERTASES allowing the rapidly release of NEUROHORMONES into the blood circulation upon stimulation.


A synthetic steroid that has been used for its anabolic action.


Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome

A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34 amino acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc8, have been shown to mediate protein-protein interactions, suggesting that Apc7 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.


COX-1 Prostaglandin Synthase
Cyclooxygenase-1
Cyclooxygenase 1
Prostaglandin H Synthase-1
Cyclo-Oxygenase I

A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes.


Spiral Ligament
Spiral Ligament of Cochlea

A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous COCHLEAR DUCT to the bony spiral canal of the COCHLEA. Its spiral ligament fibrocytes function in conjunction with the STRIA VASCULARIS to mediate cochlear ion homeostasis.


Bladder Extrophy
Exstrophy of the Bladder
Exstrophy Of Bladder
Urinary Bladder Exstrophy
Bladder Exstrophy

A birth defect in which the URINARY BLADDER is malformed and exposed, inside out, and protruded through the ABDOMINAL WALL. It is caused by closure defects involving the top front surface of the bladder, as well as the lower abdominal wall; SKIN; MUSCLES; and the pubic bone.


Trigeminal Nerve Disorders
Trigeminal Neuropathy, Idiopathic
Raeder Paratrigeminal Syndrome
Trigeminal Nerve Diseases
Cranial Nerve V Diseases
Trigeminal Neuropathy
Fifth Cranial Nerve Diseases

Diseases of the trigeminal nerve or its nuclei, which are located in the pons and medulla. The nerve is composed of three divisions: ophthalmic, maxillary, and mandibular, which provide sensory innervation to structures of the face, sinuses, and portions of the cranial vault. The mandibular nerve also innervates muscles of mastication. Clinical features include loss of facial and intra-oral sensation and weakness of jaw closure. Common conditions affecting the nerve include brain stem ischemia, INFRATENTORIAL NEOPLASMS, and TRIGEMINAL NEURALGIA.


Neoplasms, Colorectal
Colorectal Neoplasms
Colorectal Cancer
Colorectal Tumors
Colorectal Carcinoma

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.


Unwanted Pregnancies
Pregnancy, Unwanted

Pregnancy, usually accidental, that is not desired by the parent or parents.


A phylum or class of freshwater microscopic EUKARYOTA considered to be plants or MICROALGAE. Their CHLOROPLASTS (called cyanelles) are believed to be derived from the direct endosymbiosis of CYANOBACTERIA.


That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.


Imprinting, Genetic
Genetic Imprinting
Parental Imprinting
Genomic Imprinting

The variable phenotypic expression of a GENE depending on whether it is of paternal or maternal origin, which is a function of the DNA METHYLATION pattern. Imprinted regions are observed to be more methylated and less transcriptionally active. (Segen, Dictionary of Modern Medicine, 1992)


A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.


TIE2 Tyrosine Kinase
Tek Receptor
Receptor, TIE-2
Tie2 Receptor
TIE-2 Receptor Tyrosine Kinase
Angiopoietin Receptor Tie-2
TIE-2-RTK

A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).


Headache, Vascular
Cephalgia, Vascular
Vascular Headache
Vascular Headaches

Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.


Cathepsin C
Dipeptidyl Aminopeptidase I
Dipeptidyl Transferase
Dipeptidyl Peptidase I

A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.


United States Food and Drug Administration

An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.


A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).