Subacute Sclerosing Panencephalitis
Encephalitis, Inclusion Body, Measles
Leukoencephalitis, Subacute Sclerosing
Sclerosing Leukoencephalitis, Subacute
Measles Inclusion Body Encephalitis
SSPE
Sclerosing Panencephalitis, Subacute
Inclusion Body Encephalitis, Measles
Panencephalitis, Subacute Sclerosing
Van Bogaert's Leukoencephalitis
Leukoencephalitis, Van Bogaert's

A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)


Douglas' Pouch
Rectouterine Pouch
Cul-de-Sac, Douglas'
Sac of Douglas
Cul-de-Sac of Douglas

A sac or recess formed by a fold of the peritoneum.


A procedure to increase the flow of blood to the MYOCARDIUM by creating transmural channels in the heart wall via the application of laser pulses to epicardial or endocardial surfaces.


Intra-Articular Fractures
Intraarticular Fractures

Fractures of the articular surface of a bone.


A bony outgrowth on the lower surface of the CALCANEUS. Though often presenting along with plantar fasciitis (FASCIITIS, PLANTAR), they are not considered causally related.


Miller Fisher Variant of Guillain Barre Syndrome

Guillain-Barre Syndrome, Miller Fisher Variant

Guillain Barre Syndrome, Miller Fisher Variant

Ophthalmoplegia, Ataxia and Areflexia Syndrome

A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)


Hematopoiesis, Medullary
Haematopoiesis
Hematopoiesis

The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).


Immune Complexes
Immune Complex
Antigen-Antibody Complexes
Antigen-Antibody Complex

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.


Otitis Media, Suppurative
Otitis Media, Purulent

Inflammation of the middle ear with purulent discharge.


Hemeproteins whose characteristic mode of action involves transfer of reducing equivalents which are associated with a reversible change in oxidation state of the prosthetic group. Formally, this redox change involves a single-electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom (From Enzyme Nomenclature, 1992, p539). The various cytochrome subclasses are organized by the type of HEME and by the wavelength range of their reduced alpha-absorption bands.


Hereditary-Degenerative Disorders, Nervous System

Nervous System Diseases, Degenerative, Hereditary

Heredodegenerative Disorders, Nervous System

Nervous System Hereditary Degenerative Diseases

Nervous System Degenerative Hereditary Diseases

Degenerative Hereditary Diseases, Nervous System

Degenerative Disease, Nervous System, Hereditary

Degenerative Hereditary Disorders, Nervous System

Inherited disorders characterized by progressive atrophy and dysfunction of anatomically or physiologically related neurologic systems.


Matrix Metalloproteinase-9
92-kDa Type IV Collagenase
Matrix Metalloproteinase 9
Gelatinase B
MMP9 Metalloproteinase
MMP-9 Metalloproteinase
92-kDa Gelatinase

An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.


Antineoplastic Protocols
Cancer Treatment Protocols

Clinical protocols used to inhibit the growth or spread of NEOPLASMS.


Biomphalaria
Australorbis glabratus
Australorbis

A genus of planorbid freshwater snails, species of which are intermediate hosts of Schistosoma mansoni.


Ethics, Pharmaceutic
Pharmaceutical Ethics
Ethics, Pharmaceutical
Pharmaceutic Ethics
Pharmacy Ethics
Ethics, Pharmacy

The principles of proper professional conduct concerning the rights and duties of the pharmacist, relations with patients and fellow practitioners, as well as actions of the pharmacist in health care and interpersonal relations with patient families. (From Stedman, 25th ed)


Chondroectodermal Dysplasia
Ellis-Van Creveld Syndrome
Mesoectodermal Dysplasia
Ellis-Van Creveld Dysplasia

Dwarfism occurring in association with defective development of skin, hair, and teeth, polydactyly, and defect of the cardiac septum. (Dorland, 27th ed)


Hepatic Duct
Hepatic Duct, Common
Common Hepatic Duct

Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.


Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester

An organothiophosphorus cholinesterase inhibitor that is used as an insecticide and as a acaricide.


Pregnancy Complications
Complications, Pregnancy

Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.


2-Hydroxy-N-phenylbenzamides. N-phenyl substituted salicylamides. Derivatives have been used as fungicides, anti-mildew agents and topical antifungal agents. In concentrated form may cause irritation of skin and mucous membranes.


Lining of the inner surface of the cheeks.


Myoblasts, Smooth Muscle
Smooth Muscle Myoblasts

Precursor cells destined to differentiate into smooth muscle myocytes (MYOCYTES, SMOOTH MUSCLE).


Lipoperoxides
Fatty Acid Hydroperoxides
Lipid Hydroperoxide
Lipid Peroxides

Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.


rho Guanine Nucleotide Dissociation Inhibitor beta

rho Guanine Nucleotide Dissociation Inhibitor 2

A rho GDP-dissociation inhibitor subtype that is highly expressed in hematopoietic cells and in LYMPHOCYTES. The expression of this subtype is associated with the regulation of CELL PROLIFERATION; TUMORIGENESIS; and APOPTOSIS.


A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.


Paragonimus westermani Infection
Paragonimus Infection
Paragonimiasis

Infection with TREMATODA of the genus PARAGONIMUS.


HBcAg
Hepatitis B Core Antigens
Hepatitis B Core Antigen

The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.


A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)


A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.


United States National Institutes of Health

An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research.


Partial Trisomy
Trisomy
Chromosomal Triplication

The possession of a third chromosome of any one type in an otherwise diploid cell.


An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.


Non-communicable Diseases
Non-infectious Diseases
Noninfectious Diseases
Non-communicable Chronic Diseases
Noncommunicable Diseases

Diseases which are typically non-infectious in origin and do not transmit from an affected individual to others. The four main types of noncommunicable diseases are CARDIOVASCULAR DISEASES (e.g., heart attacks and stroke), CANCER, chronic respiratory diseases (e.g., CHRONIC OBSTRUCTIVE PULMONARY DISEASE and ASTHMA) and DIABETES MELLITUS.


Neurotization
Nerve Crossover
Nerve Transfer

Surgical reinnervation of a denervated peripheral target using a healthy donor nerve and/or its proximal stump. The direct connection is usually made to a healthy postlesional distal portion of a non-functioning nerve or implanted directly into denervated muscle or insensitive skin. Nerve sprouts will grow from the transferred nerve into the denervated elements and establish contact between them and the neurons that formerly controlled another area.


Hyperparathyroidism, Secondary
Secondary Hyperparathyroidism

Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.


ATP Binding Cassette Transporter, Sub-Family B, Member 1

ATP-Binding Cassette, Sub-Family B, Member 1

ATP Binding Cassette Transporter, Subfamily B, Member 1

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).


Gram-Positive Bacteria, High G+C
Actinomycetes
Actinobacteria
High G+C Gram-Positive Bacteria

Class of BACTERIA with diverse morphological properties. Strains of Actinobacteria show greater than 80% 16S rDNA/rRNA sequence similarity among each other and also the presence of certain signature nucleotides. (Stackebrandt E. et al, Int. J. Syst. Bacteriol. (1997) 47:479-491)


5,7,3',4'-tetrahydroxy-flavone, one of the FLAVONES.


Review and Rate Setting
Rate Setting, Review
Rate Setting and Review

A method of examining and setting levels of payments.


Nicotinamide Deamidase
Nicotinamide Amidohydrolase
Nicotinamidase

An enzyme that catalyzes the hydrolysis of nicotinamide to nicotinate and ammonia. EC 3.5.1.19.


Adhesive Receptor Mac-1
CR3 Receptor
Receptor, Complement 3
Integrin alpha-M beta-2
Integrin alphaMbeta2
Mo1 Antigen Receptor
Macrophage-1 Antigen
Complement 3 Receptor
Mac-1 Receptor
Receptor, Mo1 Antigen
Mac-1 Adhesive Receptor
Receptor, Mo1 Glycoprotein
Mac-1 Antigen
Receptor, CR3
Integrin alpha(M)beta(2)
Mo1 Glycoprotein Receptor

An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN. The antigen, which is an integrin, functions both as a receptor for complement 3 and in cell-cell and cell-substrate adhesive interactions.


Examination, Bone Marrow
Bone Marrow Examination

Removal of bone marrow and evaluation of its histologic picture.


Lysosomal Enzyme Disorders
Lysosomal Storage Diseases

Inborn errors of metabolism characterized by defects in specific lysosomal hydrolases and resulting in intracellular accumulation of unmetabolized substrates.


Rats, Inbred OLETF
Rats, OLETF
Otsuka-Long-Evans-Tokushima Fatty Rats
Otsuka-Long-Evans-Tokushima Rats

An inbred strain of Long-Evans rats that develops hyperglycemia, hyperinsulinemia, and mild obesity, mostly in males, that resembles non-insulin-dependent diabetes mellitus in humans. It was developed from outbred Long-Evans stock in 1983.


Gall Bladder Emptying
Gallbladder Emptying

A process whereby bile is delivered from the gallbladder into the duodenum. The emptying is caused by both contraction of the gallbladder and relaxation of the sphincter mechanism at the choledochal terminus.


Apparent Mineralocorticoid Excess Syndrome

Mineralocorticoid Excess Syndrome, Apparent

A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS.


A plant genus of the family Asparagaceae that contains steroidal SAPONINS and should not be confused with death camas (ZIGADENUS).


Mesencephalic Aqueduct
Aqueductus Cerebri
Aqueduct of Sylvius
Sylvian Aqueduct
Mesencephalic Duct
Cerebral Aqueduct

Narrow channel in the MESENCEPHALON that connects the third and fourth CEREBRAL VENTRICLES.


Encephalitis Virus
Virus, Encephalitis
Encephalitis Viruses
Viruses, Encephalitis

A collection of single-stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.


A plant genus of the family POACEAE that is considered a lawn grass by some and a weed by others. It contains allergen Cyn d 7.


Differentiation Antigens, Hairy Cell Leukemia

Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.


Adipocyte Cysteine-Rich Secreted Protein FIZZ3

A 12-kDa cysteine-rich polypeptide hormone secreted by FAT CELLS in the ADIPOSE TISSUE. It is the founding member of the resistin-like molecule (RELM) hormone family. Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake.


Perilipin A Protein
PERI Protein
Perilipin Protein
Perilipin B Protein
Plin Protein
Perilipin-1
Perilipin

A lipid droplet protein that is expressed primarily by ADIPOCYTES of WHITE ADIPOSE TISSUE and BROWN ADIPOSE TISSUE. It co-localizes with MACROPHAGES and FOAM CELLS of artherosclerotic lesions and stabilizes LIPID DROPLETS by inhibiting HORMONE SENSITIVE LIPASE. It may also protect TRIGLYCERIDES against hydrolysis within the PLASMA MEMBRANE and modulate CHOLESTEROL ESTER HYDROLASE activity.


Fusion Proteins, tpr-met
Oncogene Protein tpr-met

The GENETIC TRANSLATION product from a GENE FUSION between a sequence from the tpr protein gene on the human CHROMOSOME 1 and the gene for PROTO-ONCOGENE PROTEINS C-MET.


Porcine Insulin
Insulin, Regular, Pork
Velosulin
Insulin, Regular, Porcine

Regular insulin preparations that contain the SUS SCROFA insulin peptide sequence.


Type II Na-Dependent Phosphate Cotransporter

Type II Sodium-Phosphate Cotransporter Proteins

Type II Sodium-Phosphate Symporter Proteins

Sodium-Phosphate Cotransporter Proteins, Type II

A family of sodium-phosphate cotransporter proteins with eight transmembrane domains. They are present primarily in the KIDNEY and SMALL INTESTINE and are responsible for renal and small intestinal epithelial transport of phosphates.


Semantic Network
Semantic Web
Linked Data

A framework for development and promotion of common data formats and exchange protocols linked in a way that can be read directly by computers. Semantic Web is a platform for sharing and reusing data across application, enterprise, and community boundaries, by linking concepts rather than just documents.


A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-LYSINE onto 2-oxoglutarate to generate 2-aminoadipate 6-semialdehyde and L-GLUTAMATE.


Attachment of a bone in which its head and neck is rotated excessively backward.


Methylpartricin
Methyl Partricin
Mepartricin
SPA-S 160
Tricandil
Mepartricin A
Mepartricin B

Polyene macrolide antibiotic with unknown composition. It is obtained from Streptomyces aureofaciens. It is used as an antifungal agent, an antiprotozoal agent, and in the treatment of BENIGN PROSTATIC HYPERTROPHY.


HLA-DRB3
HLA-DRB3 Chains
HLA DRB3
HLA-DRB3 Antigen

A subtype of HLA-DRB beta chains that includes over 50 allelic variants. The HLA-DRB3 beta-chain subtype is associated with HLA-DR52 serological subtype.


Pathologic Constriction
Constriction, Pathologic
Stricture
Stenosis
Constriction, Pathological

The condition of an anatomical structure's being constricted beyond normal dimensions.


Silent Information Regulator Proteins, Saccharomyces cerevisiae

Silent Information Regulator Proteins, S cerevisiae

Silent Mating Type Information Regulator Protein, S cerevisiae

A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.


Sextuplets
Multiple Births
Multiple Birth Offspring
Multiple Birth

The offspring in multiple pregnancies (PREGNANCY, MULTIPLE): TWINS; TRIPLETS; QUADRUPLETS; QUINTUPLETS; etc.


rab3A Protein
smg25a GTP Binding Protein
smg p25A Protein
rab3A GTP-Binding Protein

The most abundant member of the RAB3 GTP-BINDING PROTEINS. It is involved in calcium-dependent EXOCYTOSIS and is localized to neurons and neuroendocrine cells. This enzyme was formerly listed as EC 3.6.1.47.


Hydrobromic acid (HBr). A solution of hydrogen bromide gas in water.


Andersen's Disease
Amylopectinosis
Gbe1 Deficiency
Glycogenosis 4
Glycogen Storage Disease Type IV
Glycogenosis IV
Glycogen Storage Disease Type 4
Andersen Disease
Glycogen Branching Enzyme Deficiency
Brancher Deficiency
Type IV Glycogenosis
Deficiency, Brancher

An autosomal recessive metabolic disorder due to a deficiency in expression of glycogen branching enzyme 1 (alpha-1,4-glucan-6-alpha-glucosyltransferase), resulting in an accumulation of abnormal GLYCOGEN with long outer branches. Clinical features are MUSCLE HYPOTONIA and CIRRHOSIS. Death from liver disease usually occurs before age 2.


Adenoviruses, Porcine
Porcine Adenoviruses

Species of the genus MASTADENOVIRUS, causing neurological disease in pigs.


Tumorigenic Transformation
Transformation, Neoplastic Cell
Neoplastic Cell Transformation
Cell Transformation, Neoplastic
Neoplastic Transformation, Cell

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.


The process by which an observer comprehends speech by watching the movements of the speaker's lips without hearing the speaker's voice.


alpha-Glucan Phosphorylases
Glucan Phosphorylase
Phosphorylases

A class of glucosyltransferases that catalyzes the degradation of storage polysaccharides, such as glucose polymers, by phosphorolysis in animals (GLYCOGEN PHOSPHORYLASE) and in plants (STARCH PHOSPHORYLASE).


Adenoma, Eosinophil
Adenoma, Eosinophilic
Adenoma, Acidophil
Adenoma, Acidophilic

A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)


A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.


Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.


Central Venous Catheter
Central Venous Catheters

Catheters that are inserted into a large central vein such as a SUBCLAVIAN VEIN or FEMORAL VEIN.


Hemostatic Techniques
Hemostatic Technics


Centrally Acting Muscle Relaxants
Muscle Relaxants, Central

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)


Insurance providing coverage for vision care.


Mal and Related Proteins for Vesicle Trafficking and Membrane Link Domain Proteins

A family of proteins that share a domain with a four transmembrane-helix architecture referred to as the MARVEL domain. The MARVEL domain proteins play important role in vesicular trafficking and in the formation of TIGHT JUNCTIONS.


Testosterone Dehydrogenases
17-Ketosteroid Reductases
17 beta-Hydroxysteroid Dehydrogenases
17-Hydroxysteroid Dehydrogenases

A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.


Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.


Compromising of Data
Computer Viruses
Information Protection
Data Protection
Computer Security
Cybersecurity
Cyber Security
Data Encryption
Computer Hackers
Data Security
Computer Worms

Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or accompanying data; especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or computer hackers aiming to compromise stored data.


Disorders Usually Diagnosed in Infancy, Childhood or Adolescence

These are a group of conditions with onset in the developmental period. The disorders typically manifest early in development, often before the child enters grade school, and are characterized by developmental deficits that produce impairments of personal, social, academic, or occupational functioning.  (From DSM-5).


Lewis X Antigen
Leu-M1 Antigens
SSEA-1 Determinant
CD15 Antigens
Stage-Specific Embryonic Antigen-1
3 alpha-Fucosyl-N-Acetyl Lactosamine
SSEA-1
Lewis X Related Antigens
Galbeta(1-4)Fucalpha(1-3)GlcNAc
Lewis X Hapten
Le(X) Antigen
Antigens, CD15
CD15 Antigen
SSEA 1
Hapten X

A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, Lewis X antigen is a stage-specific embryonic antigen.


Vasopressor Agents
Vasoconstrictor Drugs
Vasoconstrictors
Vasoactive Agonists
Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels.


Analysis, Restriction Enzyme
Restriction Enzyme Analysis
Endonuclease Mapping, Restriction
Enzyme Mapping, Restriction
Enzyme Analysis, Restriction
Restriction Mapping
Site Mapping, Restriction

Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.


Blood Coagulation Factor IV
Coagulation Factor IV
Factor IV
Calcium-40
Calcium

A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.


A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.


Pott Disease
Tuberculosis, Spinal
Pott's Disease
Pott's Paraplegia

Osteitis or caries of the vertebrae, usually occurring as a complication of tuberculosis of the lungs.


Vaginal Lavage
Vaginal Irrigation
Vaginal Douching

The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.


Vocal Ligament
Vocal Fold
Vocal Cords
Vocal Folds

A pair of cone-shaped elastic mucous membrane projecting from the laryngeal wall and forming a narrow slit between them. Each contains a thickened free edge (vocal ligament) extending from the THYROID CARTILAGE to the ARYTENOID CARTILAGE, and a VOCAL MUSCLE that shortens or relaxes the vocal cord to control sound production.


A genus of gram-negative bacteria characteristically appearing in chains of several segmenting organisms. It occurs in man and arthropod vectors and is found only in the Andes region of South America. This genus is the etiologic agent of human bartonellosis. The genus Rochalimaea, once considered a separate genus, has recently been combined with the genus Bartonella as a result of high levels of relatedness in 16S rRNA sequence data and DNA hybridization data.


A collective term for the various types of nevi and melanomas.


An enzyme that catalyzes the transfer of cytidylate (CMP) to choline phosphate to form CDPcholine. It is the rate-limiting enzyme in the choline pathway for the biosynthesis of phosphatidylcholine. Its activity is increased by glucocorticoids. EC 2.7.7.15.


Antiestrogen
Antiestrogens
Estrogen Receptor Modulator
Estrogen Receptor Modulators

Substances that possess antiestrogenic actions but can also produce estrogenic effects as well. They act as complete or partial agonist or as antagonist. They can be either steroidal or nonsteroidal in structure.


Cysteine Proteinase Inhibitors, Endogenous

Cysteine Proteinase Inhibitors, Exogenous

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.


Pulmonary Surfactant-Associated Protein A

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.


Antigens, CD80
CD80 Antigens
B7-1 Ligand
Antigen, B7-1
B7-1 Antigen
B-Cell Activation Antigen
CD80 Antigen
B7-1 Costimulatory Molecule

A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.


Regulation, Gene Expression, Leukemic
Gene Expression Regulation, Leukemic
Regulation of Gene Expression, Leukemic
Leukemic Gene Expression Regulation

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.


An enzyme that catalyzes the chlorination of a range of organic molecules, forming stable carbon-chloride bonds. EC 1.11.1.10.


Excitement, Psychomotor
Psychomotor Hyperactivity
Psychomotor Agitation
Agitation, Psychomotor
Psychomotor Restlessness
Restlessness
Akathisia

A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.


Writings originating from the 15th century A.D. to the present


Pregnancy in Diabetics
Pregnancy in Diabetes

The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.


Orthodontic Adhesives
Dental Adhesives
Dental Cement
Cement, Dental
Cements, Dental
Dental Cements
Luting Agents

Substances used to bond COMPOSITE RESINS to DENTAL ENAMEL and DENTIN. These bonding or luting agents are used in restorative dentistry, ROOT CANAL THERAPY; PROSTHODONTICS; and ORTHODONTICS.


Pilot Study
Pilot Projects
Pilot Studies

Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.


Receptors, Interstitial Cell Stimulating Hormone

Receptors, Interstitial Cell-Stimulating Hormone

Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesize and secrete sex steroids. The hormone-receptor complex is internalized from the plasma membrane and initiates steroid synthesis.


The most common form of DNA found in nature. It is a right-handed helix with 10 base pairs per turn, a pitch of 0.338 nm per base pair and a helical diameter of 1.9 nm.


DNA, Recombinant
Genes, Spliced
Recombinant DNA Research
Recombinant DNA
Recombination Joint

Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.


An abnormal elevation of body temperature, usually as a result of a pathologic process.


Enzymes that recombine DNA segments by a process which involves the formation of a synapse between two DNA helices, the cleavage of single strands from each DNA helix and the ligation of a DNA strand from one DNA helix to the other. The resulting DNA structure is called a Holliday junction which can be resolved by DNA REPLICATION or by HOLLIDAY JUNCTION RESOLVASES.


Clathrin Assembly Protein Complex delta Subunits

A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.


An enzyme that catalyzes the endohydrolysis of 1,6-alpha-glucosidic linkages in isomaltose and dextrins produced from starch and glycogen by ALPHA-AMYLASES. EC 3.2.1.10.


Complement Component 4b-Binding Protein
Complement C4b-Binding Protein
C4bC3bINA-Cofactor
C4b-C3b Inactivator Cofactor
C4b-Binding Protein
Complement C3b-C4b Inactivator Cofactor
Complement 4b Binding Protein

A serum protein that regulates the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. It binds as a cofactor to COMPLEMENT FACTOR I which then hydrolyzes the COMPLEMENT C4B in the CLASSICAL PATHWAY C3 CONVERTASE (C4bC2a).


Primary Thrombocythemia
Hemorrhagic Thrombocythemia
Thrombocythemia, Essential
Thrombocytosis, Autosomal Dominant
Thrombocythemia, Idiopathic
Thrombocythemia, Hemorrhagic
Thrombocythemia, Primary
Thrombocytosis, Primary

A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.


A cyclin subtype that binds to the CYCLIN-DEPENDENT KINASE 3 and CYCLIN-DEPENDENT KINASE 8. Cyclin C plays a dual role as a transcriptional regulator and a G1 phase CELL CYCLE regulator.


Members of the phylum ARTHROPODA composed or organisms characterized by division into three parts: head, thorax, and abdomen. They are the dominant group of animals on earth with several hundred thousand different kinds. Three orders, HEMIPTERA; DIPTERA; and SIPHONAPTERA; are of medical interest in that they cause disease in humans and animals. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p1).


CCL27 Chemokine
ESkine
Cutaneous T-Cell-Attracting Chemokine
Chemokine CCL27
Small Inducible Cytokine A27
CTACK Chemokine

A CC-type chemokine with specificity for CCR10 RECEPTORS. It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION.


Anti-Sense Oligonucleotides
Oligonucleotides, Antisense
Antisense Oligonucleotides

Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.


A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta.


Receptor, Cholecystokinin A
CCK(1) Receptor
CCK-A Receptor
Cholecystokinin A Receptor

A subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.


Cytochrome B-245 Beta Chain
NADPH Oxidase 2
CYBB Protein
Chronic Granulomatous Disease Protein
NOX2 Protein
GP91-PHOX Protein

An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.


Cephaloglycin
Cephaloglycin Dihydrate
Cephaloglycine
Cefaloglycin


Consensus Development Conferences, NIH as Topic

NIH Consensus Development Conferences as Topic

Articles on conferences sponsored by NIH presenting summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus on a subject of interest. This heading is used for NIH consensus conferences as a means of scientific communication. In indexing it is viewed as a type of review article and as a tag for any article appearing in any publication of the NIH Office of Medical Applications of Research (OMAR).


Nuclear Trans-Acting Factor
Trans-Acting Factors
Trans-Acting Factor
Trans-Activator
Trans-Activators
Transactivators
Transactivator

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.


Substance-Induced Psychoses
Psychoses, Substance-Induced
Psychoses, Toxic
Psychoses, Drug
Toxic Psychoses

Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.


Aqueous Shunts
Glaucoma Drainage Implants
Aqueous Humor Shunts
Krupin Valves
Baerveldt Implants
Glaucoma Filtration Implants

Devices, usually incorporating unidirectional valves, which are surgically inserted in the sclera to maintain normal intraocular pressure.


Administration Routes, Drug
Drug Administration Routes

The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.


Elementary Particles
Baryons
Fundamental Particles

Individual components of atoms, usually subatomic; subnuclear particles are usually detected only when the atomic nucleus decays and then only transiently, as most of them are unstable, often yielding pure energy without substance, i.e., radiation.


The field of medicine concerned with conditions affecting the health of people in submarines or sealabs.


Fixed sums paid regularly to individuals.


Nasal Obstruction
Nasal Blockage
Unilateral Nasal Obstruction
Bilateral Nasal Obstruction
Nasal Airway Obstruction

Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.


Retinoid X Receptor-Interacting Protein 13

A nuclear protein that regulates the expression of genes involved in a diverse array of processes related to metabolism and reproduction. The protein contains three nuclear receptor interaction domains and three repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 2.


The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.


Raphe Obscurus Nucleus
Nucleus Obscurus Raphe
Nucleus Raphe Obscurus
Nucleus Raphes Obscurus

A nucleus in the medullary Raphe nuclei located caudal to the NUCLEUS RAPHE PALLIDUS.


Thiosphaera pantotropha
Paracoccus pantotrophus

A species of gram-negative, coccoid, mostly chemolithoautotrophic bacteria, in the family RHODOBACTERACEAE. Some strains can grow anaerobically.


Connective and Soft Tissue Neoplasms
Neoplasms, Connective and Soft Tissue

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.


HNPCC1 Protein
MutS Homolog 2 Protein
HNPCC Protein

A highly conserved eukaryotic homolog of the MUTS DNA MISMATCH-BINDING PROTEIN. It plays an essential role in meiotic RECOMBINATION and DNA REPAIR of mismatched NUCLEOTIDES.


Group Process
Group Processes
Group Thinking
Group Meetings

A faulty dynamic with a group that may lead to poor conclusions and beliefs.


Coronaviridae Infections
Infections, Coronaviridae


tRNA Ligase
RNA Ligase (ATP)
Polyribonucleotide Synthetase

An enzyme that catalyzes the conversion of linear RNA to a circular form by the transfer of the 5'-phosphate to the 3'-hydroxyl terminus. It also catalyzes the covalent joining of two polyribonucleotides in phosphodiester linkage. EC 6.5.1.3.


Stilbenoids
Stilbenes
Stilbene Derivatives

Organic compounds that contain 1,2-diphenylethylene as a functional group.


Regression Analysis
Analysis, Regression
Regression Diagnostics
Statistical Regression

Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.


Heparan Sulfate Proteoglycan
Heparan Sulfate Proteoglycans
HSPG
Proteoheparan Sulfate

Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)


Values, Social
Social Values
Value Orientation

Abstract standards or empirical variables in social life which are believed to be important and/or desirable.


Q-N-ethylmaleimide-Sensitive-Factor Attachment Protein Receptors

SNARE proteins in which the central amino acid residue of the SNARE motif is a GLUTAMINE. They are classified separately from the R-SNARE PROTEINS where the central amino acid residue of the SNARE motif is an ARGININE. Subfamilies, the QA-SNARES; QB-SNARES; and QC-SNARES are grouped by the position of their SNARE motif-containing-domains in the SNARE complex and by their sequence similarities.


A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.


Warfare involving the use of NUCLEAR WEAPONS.


A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.


Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.


An oval semitransparent membrane separating the external EAR CANAL from the tympanic cavity (EAR, MIDDLE). It contains three layers: the skin of the external ear canal; the core of radially and circularly arranged collagen fibers; and the MUCOSA of the middle ear.


DNA sequences that form the coding region for the protein responsible for trans-activation of transcription (tat) in human immunodeficiency virus (HIV).


An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.


Onychoosteodysplasia
Fong Disease
Hereditary Onycho-Osteodysplasia
Osteo-Onychodysplasia, Hereditary
Osterreicher Syndrome
Pelvic Horn Syndrome
Hereditary Osteo-Onychodysplasias
Turner-Kieser Syndrome
Nail-Patella Syndrome

A syndrome of multiple abnormalities characterized by the absence or hypoplasia of the PATELLA and congenital nail dystrophy. It is a genetically determined autosomal dominant trait.


Infections with bacteria of the genus PROTEUS.


Velopharyngeal Sphincter
Palatopharyngeal Sphincter

A group of muscles attached to the SOFT PALATE (or velum) and the PHARYNX. They include the superior constrictor, the PALATOPHARYNGEUS, the levator veli palatini muscle, and the muscularis uvulae. This sphincter is situated between the oral and nasal cavities. A competent velopharyngeal sphincter is essential for normal speech and swallowing.


Organ Transplantation
Transplantation, Organ
Grafting, Organ

Transference of an organ between individuals of the same species or between individuals of different species.


Leishmaniasis Vaccines
Leishmania Vaccines

Vaccines or candidate vaccines used to prevent infection with LEISHMANIA.


An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.


Bioaffinity Chromatography
Affinity Chromatography
Chromatography, Affinity
Immunochromatography
Chromatography, Bioaffinity

A type of affinity chromatography where ANTIBODIES are used in the affinity capture reaction on the solid support, in the mobile phase, or both.


Nudivirus
Oryctes Viruses
Nudiviridae
Nudiviruses

A family of ARTHROPOD viruses, including INSECT VIRUSES and crustacean viruses. They are rod-shaped, enveloped, and circular dsDNA viruses that share structural and replication characteristics with BACULOVIRIDAE. Genera include Alphanudivirus and Betanudivirus.


Hydrocholeretics
Cholagogues
Cholagogues, Choleretics
Choleretics
Cholagogues and Choleretics
Choleretics and Cholagogues

Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).


A ubiquitously expressed member of the syntaxin subfamily of SNARE proteins that localizes to the GOLGI APPARATUS.


Proteus-Like Syndrome
Proteus Syndrome
Elephant Man Disease

Hamartoneoplastic malformation syndrome of uncertain etiology characterized by partial GIGANTISM of the hands and/or feet, asymmetry of the limbs, plantar hyperplasia, hemangiomas (HEMANGIOMA), lipomas (LIPOMA), lymphangiomas (LYMPHANGIOMA), epidermal NEVI; MACROCEPHALY; cranial HYPEROSTOSIS, and long-bone overgrowth. Joseph Merrick, the so-called "elephant man", apparently suffered from Proteus syndrome and not NEUROFIBROMATOSIS, a disorder with similar characteristics.


Blood Coagulation Tests
Coagulation Tests, Blood
Tests, Blood Coagulation

Laboratory tests for evaluating the individual's clotting mechanism.


Carcinoma, Colloid
Adenocarcinoma, Mucinous
Carcinoma, Mucinous

An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)


Ig J-Peptide
Immunoglobulin J Polypeptide
J-Chains, Immunoglobulin
Immunoglobulin J-Chains
Immunoglobulin J-Peptide
Ig J Chains

A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.


Spinal Roots
Ventral Roots
Dorsal Roots
Spinal Nerve Roots

Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.


kappa-Chain Immunoglobulins
kappa-Immunoglobulin Subgroup VK-21
Immunoglobulin kappa-Chain
Immunoglobulins, kappa-Chain
Ig kappa Chains
kappa-Immunoglobulin Light Chains
kappa-Immunoglobulin Subgroup VK-12
Immunoglobulin kappa-Chains
kappa-Immunoglobulin Light Chain

One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.


Bovine Immunodeficiency Virus
BIV
Immunodeficiency Virus, Bovine
Bovine Immunodeficiency-Like Virus

The type species of LENTIVIRUS, subgenus bovine lentiviruses (LENTIVIRUSES, BOVINE), found in cattle and causing lymphadenopathy, LYMPHOCYTOSIS, central nervous system lesions, progressive weakness, and emaciation. It has immunological cross-reactivity with other lentiviruses including HIV.


Cytochrome a3
Cytochrome a(3)
Cytochromes a3
Ferrocytochrome a3

A subclass of heme a containing cytochromes with an alpha-band absorption of 605 nm. They are found in a variety of microorganisms and in eukaryotes as a high-spin cytochrome component of MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.


T-Lymphotropic Virus Type III Antibodies, Human

T Lymphotropic Virus Type III Antibodies, Human


Hepatitis B Vaccines
Hepatitis B Vaccine

Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.


Antihypertensives
Anti-Hypertensive Agents
Anti-Hypertensive Drugs
Anti-Hypertensives
Antihypertensive Agents
Antihypertensive Drugs

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.


Ledderhose's Disease
Fibromatosis, Plantar
Ledderhose Disease

A fibromatosis of the plantar fascia characterized by thickening of the fibrous bands on the plantar aponeurosis in the sole of the foot and toes.


Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.


Enteropathogenic Escherichia coli
Escherichia coli, Enteropathogenic
Enteropathogenic E. coli
EPEC
E coli, Enteropathogenic

Strains of ESCHERICHIA COLI characterized by attaching-and-effacing histopathology. These strains of bacteria intimately adhere to the epithelial cell membrane and show effacement of microvilli. In developed countries they are associated with INFANTILE DIARRHEA and infantile GASTROENTERITIS and, in contrast to ETEC strains, do not produce ENDOTOXINS.


Trypanosoma congolense
Trypanosoma (Nannomonas) congolense

A species of Trypanosome hemoflagellates that is carried by tsetse flies and causes severe anemia in cattle. These parasites are also found in horses, sheep, goats, and camels.


Intracranial Hemorrhages
Hemorrhage, Intracranial
Brain Hemorrhage
Posterior Fossa Hemorrhage

Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.


A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).


Spider Mites
Tetranychidae
Mites, Spider

Family of spider MITES, in the superfamily Tetranychoidea, suborder Trombidiformes.


Interleukin Receptor
Receptors, Interleukins
Interleukin Receptors
Receptors, Interleukin

Cell surface proteins that bind interleukins and trigger intracellular changes influencing the behavior of cells.


Dishevelled Protein
Dishevelled Proteins
Dishevelled-3 Protein
Dishevelled-2 Protein
Dishevelled-1 Protein

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.


Pharmacogenomic Variants
Pharmacokinetic Genetic Variants
Pharmacogenetic Variants

Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).


Heterogeneous Nuclear Ribonucleoprotein D0

AU-rich Element RNA-binding Protein 1, 37 kDa

Member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) specifically binds RNA molecules that contain AU RICH ELEMENTS found within the 3'-UTR of many PROTO-ONCOGENES and CYTOKINES mRNAs. It functions as a transcription factor, binds to double- and single-stranded DNA sequences in a specific manner.


Transplantation, Heterologous
Heterologous Transplantation
Heterograft Transplantation
Heterografting
Xenograft Transplantation
Xenotransplantation
Xenografting

Transplantation between animals of different species.


Beverages used in TRADITIONAL MEDICINE that are prepared from the infusion of plant tissue (HERBAL TEA), and/or animal tissue or other organisms such as FUNGI.


Angle Class I
Malocclusion, Angle Class I

Malocclusion in which the mandible and maxilla are anteroposteriorly normal as reflected by the relationship of the first permanent molar (i.e., in neutroclusion), but in which individual teeth are abnormally related to each other.


Hypesthesia, Tactile
Hypesthesia
Hypoesthesia
Impaired Sensation
Hypesthesia, Thermal
Reduced Sensation
Numbness

Absent or reduced sensitivity to cutaneous stimulation.


An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.


Cordocentesis
Percutaneous Umbilical Blood Sampling
Cord Blood Sampling

The collecting of fetal blood samples typically via ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE ASPIRATION from the umbilical vein.


Type 3 Von Willebrand's Disease
Type 3 VWD
von Willebrand Disease, Type 3
Von Willebrand Disease, Severe Form

A subtype of von Willebrand disease that results from a total or near total deficiency of VON WILLEBRAND FACTOR.


Bufo marinus
Toad, Giant
Toad, Marine
Rhinella marina

A species of the true toads, Bufonidae, becoming fairly common in the southern United States and almost pantropical. The secretions from the skin glands of this species are very toxic to animals.


A genus of Old World monkeys, subfamily COLOBINAE, family CERCOPITHECIDAE, that inhabits the forests of Africa. It consists of eight species: C. angolensis (Angolan colobus), C. badius or C. rufomitratus (Red or Bay colobus), C. guereza (Guereza or Eastern black-and-white colobus), C. kirkii (Kirk's colobus), C. polykomos (King colobus or Western black-and-white colobus), C. satanas (Black colobus), and C. verus (Olive colobus). Some authors recognize Procolobus as a separate genus and then the olive colobus is recognized as the species P. verus.


Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.


Prescription Drug Overuse
Prescription Drug Overutilization
Medication Overutilization
Medication Overuse

The use of a medication in an amount more than as prescribed.


Sex Selection
Sex Preselection
Sex Predetermination

Methods for controlling genetic SEX of offspring.


Babesia Infection
Babesia Parasite Infection
Babesiasis
Piroplasmosis
Human Babesiosis
Babesiosis

A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.


Water Lily
Lily, Water
Nymphaea
Waterlily
Nymphaea lotus

A genus of Nymphaea, also called white Egyptian lotus, which should not be confused with the unrelated genus Lotus (LOTUS) or with NELUMBO species which they resemble and are also commonly called lotus.


Nucleotides containing arabinose as their sugar moiety.


The brain stem nucleus that receives the central input from the cochlear nerve. The cochlear nucleus is located lateral and dorsolateral to the inferior cerebellar peduncles and is functionally divided into dorsal and ventral parts. It is tonotopically organized, performs the first stage of central auditory processing, and projects (directly or indirectly) to higher auditory areas including the superior olivary nuclei, the medial geniculi, the inferior colliculi, and the auditory cortex.


Retinal Cone Photoreceptor Cells
Retinal Cone
Cone Photoreceptors
Retinal Cone Photoreceptors
Cones (Retina)
Cone Photoreceptor Cells
Retinal Cone Cells
Photoreceptors, Cone

Photosensitive afferent neurons located primarily within the FOVEA CENTRALIS of the MACULA LUTEA. There are three major types of cone cells (red, blue, and green) whose photopigments have different spectral sensitivity curves. Retinal cone cells operate in daylight vision (at photopic intensities) providing color recognition and central visual acuity.


The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.


Irradiation, Half-Body
Hemibody Irradiation
Irradiation, Hemibody
Sequential Hemibody Irradiation
Systemic Hemibody Irradiation
Half-Body Irradiation
Hemi-Body Irradiation

Irradiation of one half or both halves of the body in the treatment of disseminated cancer or widespread metastases. It is used to treat diffuse metastases in one session as opposed to multiple fields over an extended period. The more frequent treatment modalities are upper hemibody irradiation (UHBI) or lower hemibody irradiation (LHBI). Less common is mid-body irradiation (MBI). In the treatment of both halves of the body sequentially, hemibody irradiation permits radiotherapy of the whole body with larger doses of radiation than could be accomplished with WHOLE-BODY IRRADIATION. It is sometimes called "systemic" hemibody irradiation with reference to its use in widespread cancer or metastases. (P. Rubin et al. Cancer, Vol 55, p2210, 1985)


Cytidine Monophosphate N-Acetylneuraminic Acid

Cytidine Monophosphate N Acetylneuraminic Acid

A nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein.


Pneumonia, Rickettsial
Rickettsial Pneumonia

Pneumonia caused by infection with bacteria of the family RICKETTSIACEAE.


A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein

An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.


The process by which the nature and meaning of tactile stimuli are recognized and interpreted by the brain, such as realizing the characteristics or name of an object being touched.


Swiss Blue
Methylthionine Chloride
Methylene Blue
Basic Blue 9
Chromosmon
Methylene Blue N
Urolene Blue
Methylthioninium Chloride

A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.


Cardiotonic Drugs
Cardiotonics
Cardioprotective Agents
Cardiac Stimulants
Inotropic Agents, Positive Cardiac
Cardiotonic Agents
Myocardial Stimulants

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).


Bone Cements
Bone Paste
Bone Glues
Bone Glue
Bone Pastes

Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.


Gloves, usually rubber, worn by surgeons, examining physicians, dentists, and other health personnel for the mutual protection of personnel and patient.


Federal Trade Commission (U.S.)
Federal Trade Commission
United States Federal Trade Commission
USFTC

An independent administrative agency concerned with maintaining competitive free enterprise by prohibiting unfair methods of competition and unfair deceptive acts or practices.


Chronic Hepatitis B
Hepatitis B Virus Infection, Chronic
Hepatitis B, Chronic
Chronic Hepatitis B Virus Infection

INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.


Glucose Dehydrogenase
Glucose 1-Dehydrogenase

A glucose dehydrogenase that catalyzes the oxidation of beta-D-glucose to form D-glucono-1,5-lactone, using NAD as well as NADP as a coenzyme.


Community Dentistry
Dentistry, Community

The practice of dentistry concerned with preventive as well as diagnostic and treatment programs in a circumscribed population.


Lysosomal beta A Mannosidosis
beta-Mannosidosis
beta-Mannosidase Deficiency
Lysosomal beta-Mannosidase Deficiency
Mannosidosis, beta A, Lysosomal

An inborn error of metabolism marked by a defect in the lysosomal isoform of BETA-MANNOSIDASE that results in lysosomal accumulation of mannose-rich intermediate metabolites containing 1,4-beta linkages. The human disease occurs through autosomal recessive inheritance and manifests in the form of a variety of symptoms that depend upon the type of gene mutation.


Cytochrome P-450 IIE1
Cytochrome P-450 (ALC)
Cytochrome P-450-J
Cytochrome P-450 CYP2E1
Dimethylnitrosamine N-Demethylase
CYP IIE1
CYP 2E1
CYPIIE1
N-Nitrosodimethylamine Demethylase
4-Nitrophenol-2-Hydroxylase
Cytochrome P450 2E1
CYP2E1

An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.


Bridged Bicyclo Compounds, Heterocyclic
Heterocyclic Cpds, Bicyclic
Heterocyclic Bicyclo Compounds
Bicyclo Compounds, Heterocyclic
Bicyclic Heterocyclic Compounds

Heterocyclic compounds that contain two rings that share two non-adjacent atoms in common.


CD49a Antigen
alpha1 Integrin
VLA-1 alpha Subunit
Antigens, CD49a
Integrin alpha1
CD49a Antigens
Integrin alpha(1)

An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.


TFF3 Protein
Intestinal Trefoil Factor
TFF3 Peptide
Trefoil Factor-3

A 59 amino acid (6.6 kDa) trefoil factor that contains a single trefoil domain. It is expressed in all tissues with MUCOUS MEMBRANES, including GOBLET CELLS of the SMALL INTESTINE and LARGE INTESTINE. It associates with MUCIN-2 in the small intestine and may regulate epithelial CELL MIGRATION and WOUND HEALING.


A plant genus of the family ASCLEPIADACEAE. Members contain the alkaloids quindoline, CSA-3, cryptolepine, and neocryptolepine.


A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).


Diseases of domestic and mountain sheep of the genus Ovis.


Minor Histocompatibility Loci
Histocompatibility Loci, Minor

Genetic loci responsible for the encoding of histocompatibility antigens other than those encoded by the MAJOR HISTOCOMPATIBILITY COMPLEX. The antigens encoded by these genes are often responsible for graft rejection in cases where histocompatibility has been established by standard tests. The location of some of these loci on the X and Y chromosomes explains why grafts from males to females may be rejected while grafts from females to males are accepted. In the mouse roughly 30 minor histocompatibility loci have been recognized, comprising more than 500 genes.


TMEM16A Protein
Transmembrane Protein 16A
Anoctamin-1

An anoctamin chloride channel expressed at high levels in the liver, skeletal muscle, and gastrointestinal muscles that functions in transepithelial anion transport and smooth muscle contraction. It is essential for the function of the INTERSTITIAL CELLS OF CAJAL and plays a major role in chloride conduction by airway epithelial cells and in tracheal cartilage development.


Transplantation, Tissue
Tissue Transplantation
Grafting, Tissue

Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.


National Institute of Dental and Craniofacial Research (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It seeks to improve oral, dental and craniofacial health through research, research training, and the dissemination of health information by conducting and supporting basic and clinical research. It was established in 1948 as the National Institute of Dental Research and re-named in 1998 as the National Institute of Dental and Craniofacial Research.


Conclusions derived from the nursing assessment that establish a health status profile for the patient and from which nursing interventions may be ordered.


Fluorine-19 Magnetic Resonance Imaging
19F MRI

Magnetic resonance imaging diagnostic technique which uses fluorine-19 perfluorocarbon probes and contrast agents for high resolution image detection and quantitation.


Neuronal Tract-Tracers
Neuroanatomical Tract-Tracing Markers

Substances used to identify the location and to characterize the types of NEURAL PATHWAYS.


An order of flightless birds comprising the ostriches, which naturally inhabit open, low rainfall areas of Africa.


(Methyl-ONN-azoxy)methanol Acetate
Methylazoxymethanol Acetate

The aglycone of CYCASIN. It acts as a potent carcinogen and neurotoxin and inhibits hepatic DNA, RNA, and protein synthesis.


IPNV
Pancreatic Necrosis Virus, Infectious
Infectious pancreatic necrosis virus

The type species of AQUABIRNAVIRUS, causing infectious pancreatic necrosis in salmonid fish and other freshwater and marine animals including mollusks.


Esquinon Carboquinone Carbazilquinone Carboquone

An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.


Accelerated Idioventricular Rhythm
AIVR
Slow Ventricular Tachycardia

A type of automatic, not reentrant, ectopic ventricular rhythm with episodes lasting from a few seconds to a minute which usually occurs in patients with acute myocardial infarction or with DIGITALIS toxicity. The ventricular rate is faster than normal but slower than tachycardia, with an upper limit of 100 -120 beats per minute. Suppressive therapy is rarely necessary.


Legg-Calve-Perthes Disease
Coxa Plana
Legg-Perthes Disease
Legg-Calvé-Perthes Disease
Osteochondritis Deformans
Legg-Calvé-Perthes Syndrome
Perthes Disease
Legg-Calve-Perthes Syndrome

A particular type of FEMUR HEAD NECROSIS occurring in children, mainly male, with a course of four years or so.


Subacute Bacterial Endocarditis
Bacterial Endocarditides, Subacute
Endocarditides, Subacute Bacterial
Endocarditis Lenta
Subacute Bacterial Endocarditides
Endocarditis, Subacute Bacterial
Bacterial Endocarditis, Subacute

ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.


Oxoquinolines Ketoquinolines Quinolones Quinolinones

A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.


0.9% NaCl
Normal Saline
Saline Solution
0.9% Saline

A crystalloid solution that contains 9.0g of SODIUM CHLORIDE per liter of water. It has a variety of uses, including: as a CONTACT LENS SOLUTION, in OPHTHALMIC SOLUTIONS and NASAL LAVAGE, in wound irrigation, and for FLUID THERAPY.


Warming-Down Exercise
Cool-Down Exercise
Warm-Down Exercise
Cooling-Down Exercise
Cooldown Exercise

Tapering-off physical activity from vigorous to light, to gradually return the body to pre-exercise condition and metabolic state.


3-Methoxy-4-Hydroxyphenylacetic Acid
Homovanillic Acid
4-Hydroxy-3-Methoxyphenylacetic Acid

A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.


Factor XIII Deficiency
Deficiency, Factor XIII
Factor Thirteen Deficiency
Deficiency, Factor 13
Factor 13 Deficiency
Deficiency, Factor Thirteen

A deficiency of blood coagulation FACTOR XIII or fibrin stabilizing factor (FSF) that prevents blood clot formation and results in a clinical hemorrhagic diathesis.


Gallamine Triethyl Iodide
Flaxedil
Gallamine Triethiodide
Gallamine Triethochloride
Gallamine
Gallamonium Iodide

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)


A resinous substance obtained from beehives that is used traditionally as an antimicrobial. It is a heterogeneous mixture of many substances.


Antithrombins
Direct Antithrombins
Direct Thrombin Inhibitors

Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.


Embolism, Amniotic Fluid
Amniotic Fluid Embolism

Blocking of maternal circulation by AMNIOTIC FLUID that is forced into uterine VEINS by strong UTERINE CONTRACTION near the end of pregnancy. It is characterized by the sudden onset of severe respiratory distress and HYPOTENSION that can lead to maternal DEATH.


p-Hydroxynorephedrine
para-Hydroxynorephedrine
p Hydroxynorephedrine

Parahydroxy analog of phenylpropanolamine with properties as a sympathomimetic.


Exposure Therapy
Imaginal Flooding
Flooding, Imaginal
Implosive Therapy
Therapy, Implosive
Flooding Therapy

A method for treatment of anxiety disorders using repeated presentations of a specific stimulus to habituate the subject, and extinguish normal innate and acquired fear.


Oncogene Proteins v-abl
Oncogene Products v-abl
v-abl Proteins
abl Oncogene Proteins

Transforming proteins encoded by the abl oncogenes. Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific N-terminal amino acids.


Cardiovirus Infections
Infections, Cardiovirus

Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.


Leukemias, Experimental
Experimental Leukemia
Leukemia, Experimental
Experimental Leukemias
Leukemia Model, Animal

Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.


Coated Pits, Cell-Membrane
Cell-Membrane Coated Pits
Bristle-Coated Pits

Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. These pits are the entry route for macromolecules bound by cell surface receptors. The pits are then internalized into the cytoplasm to form the COATED VESICLES.


Measles, German
Rubella
Three Day Measles

An acute infectious disease caused by the RUBELLA VIRUS. The virus enters the respiratory tract via airborne droplet and spreads to the LYMPHATIC SYSTEM.


Cerebral Peduncles
Cerebral Peduncle
Basis Pedunculi Cerebri
Basis Pedunculi
Pedunculus Cerebri

Ventral portion of the mesencephalon including the MIDBRAIN TEGMENTUM; CRUS CEREBRI; and the PRETECTUM. It does not include tectum mesencephali and TROCHLEAR NERVE.


Dentition, Mixed
Dentition, Transitional

The complement of teeth in the jaws after the eruption of some of the permanent teeth but before all the deciduous teeth are absent. (Boucher's Clinical Dental Terminology, 4th ed)


Chronic Disease Surveillance
Chronic Disease Indicators

A set of surveillance indicators of disease developed by consensus among the CDC, the Council of State and Territorial Epidemiologists, and the National Association of Chronic Disease Directors. It enables public health professionals and policymakers to retrieve uniformly defined state and selected metropolitan-level data for CHRONIC DISEASES and RISK FACTORS that impact public health.(https://www.cdc.gov/socialdeterminants/data/index.htm)


Kyasanur Forest Disease Virus Infection
Kyasanur Forest Disease

Tick-borne flavivirus infection occurring in the Kyasanur Forest in India.


Gan zao
Glycyrrhiza uralensis
Gan cao
Chinese Licorice


Interleukin-11 Receptor alpha Subunit
alpha-subunit, Receptor, Interleukin-11

A low affinity interleukin-11 receptor subunit that combines with the CYTOKINE RECEPTOR GP130 to form a high affinity receptor for INTERLEUKIN-11. Multiple isoforms of this protein exist due to ALTERNATIVE SPLICING of its MRNA.


Bone-Prosthesis Interface
Bone-Implant Interface

Region of interaction between the bone and PROSTHESES AND IMPLANTS which becomes bonded through cellular and extracellular interactions similar to OSSEOINTEGRATION.


The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.


Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.


The innermost digit of the foot in PRIMATES.


NADPH Dehydrogenase
Old Yellow Enzyme
NADP Diaphorase
NADP Dehydrogenase
NADPH Diaphorase
TPN Diaphorase

A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1.


Invasive Mycoses
Invasive Fungal Infections

Mycoses which manifest as infections of deep tissue or blood.


Preterm Infants
Premature Infants
Neonatal Prematurity
Infant, Premature

A human infant born before 37 weeks of GESTATION.


Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.


Physician-Nurse Relations
Nurse-Physician Relations
Physician Nurse Relationship

The reciprocal interaction of physicians and nurses.


Endoscopic instruments used for viewing the rectovaginal pouch and pelvic viscera.


Hepatocellular Carcinoma
Liver Cell Carcinoma
Carcinoma, Hepatocellular
Liver Cancer, Adult
Liver Cell Carcinoma, Adult
Hepatoma

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.


Mainstreaming, Education
Mainstreaming (Education)
Educational Mainstreaming
Mainstreaming, Educational

Most frequently refers to the integration of a physically or mentally disabled child into the regular class of normal peers and provision of the appropriately determined educational program.


Transfer (Psychology)
Transfer of Training
Transfer of Learning
Transfer, Psychology

Change in learning in one situation due to prior learning in another situation. The transfer can be positive (with second learning improved by first) or negative (where the reverse holds).


Receptors, Notch
Notch Proteins
Notch Receptors

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.


Focal Epithelial Hyperplasia, Oral
Hyperplasia, Focal Epithelial
Heck Disease
Heck's Disease
Focal Epithelial Hyperplasia

Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, presenting soft, painless, round to oval sessile papules about 1 to 4 mm in diameter. The condition usually occurs in children and young adults and has familial predilection, lasting for several months, sometimes years, before running its course. A viral etiology is suspected, the isolated organism being usually the human papillomavirus. (Jablonski, Illustrated Dictionary of Dentistry; Belshe, Textbook of Human Virology, 2d ed, p954)


Tumor Necrosis Factor Receptor Superfamily, Member 13b

Transmembrane Activator and CAML Interactor Protein

A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.


Des-Aspartyl-Angiotensin II
Des-Asp Angiotensin II
Angiotensin III

A heptapeptide formed from ANGIOTENSIN II after the removal of an amino acid at the N-terminal by AMINOPEPTIDASE A. Angiotensin III has the same efficacy as ANGIOTENSIN II in promoting ALDOSTERONE secretion and modifying renal blood flow, but less vasopressor activity (about 40%).


Prenazone Feprazone Zepelin Brotazona DA-2370 Fenilprenazone Phenylprenazone

A pyrazole that has analgesic, anti-inflammatory, and antipyretic properties. It has been used in mild to moderate pain, fever, and inflammation associated with musculoskeletal and joint disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p15)


Receptors, Adenosine A2
Adenosine A2 Receptors
Adenosine A2 Receptor

A subclass of ADENOSINE RECEPTORS that are generally considered to be coupled to the GS, STIMULATORY G-PROTEIN which causes up regulation of CYCLIC AMP.


Movement Disorder, Stereotypic
Stereotypic Movement Disorder
Head Banging
Body Rocking

Motor behavior that is repetitive, often seemingly driven, and nonfunctional. This behavior markedly interferes with normal activities or results in severe bodily self-injury. The behavior is not due to the direct physiological effects of a substance or a general medical condition. (DSM-IV, 1994)


L-Leucylnaphthylamidase
Peptidase S
Leucyl Aminopeptidase
Methoxyleucine Aminopeptidase
Zinc-Manganese-Leucine Aminopeptidase
Leucine Aminopeptidase
Cytosol Aminopeptidase

A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.


A class of endosymbiont EUKARYOTES, in the group PARABASALIDEA, that are obligate mutualists in the digestive tracts of wood-eating insects. Hypermastigotes produce CELLULASE that breaks down the cellulose in wood so that insects can metabolize it.


High Mobility Group Chromosomal Proteins

A family of low-molecular weight, non-histone proteins found in chromatin.


Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day.


Superinvasion, Microbial
Superinfection
Microbial Superinvasion

A frequent complication of drug therapy for microbial infection. It may result from opportunistic colonization following immunosuppression by the primary pathogen and can be influenced by the time interval between infections, microbial physiology, or host resistance. Experimental challenge and in vitro models are sometimes used in virulence and infectivity studies.


Psychooncology
Psychosocial Oncology
Psycho-Oncology

A specialty which deals with the interrelationship of physical, psychological, social, behavioral, and ethical aspects of cancer. Psycho-oncology examines the behavioral and psychosocial factors that may influence the course of the disease, cancer risk, prevention, and detection.


TCGF Receptor
IL-2 Receptor
IL-2 Receptors
Receptors, IL-2
IL2 Receptors
Interleukin-2 Receptors
Receptors, T-Cell Growth Factor
Interleukin 2 Receptor
T-Cell Growth Factor Receptor
T-Cell Growth Factor Receptors
Receptor, TCGF
TCGF Receptors
Receptors, Interleukin-2
IL2 Receptor

Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.


Physiome
Patient-Specific Computational Modeling
Patient-Specific Modeling

The quantitative and integrated description of the functional behavior of the physiological state of an individual or species.


CYP2C8 Inhibitors
P450 CYP2C8 Inhibitors
Cytochrome P-450 CYP2C8 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C8.


Methylmethacrylate Methyl Monomer
Kallocryl
Cranioplast
Metaplex
Sintex
Simplex P
Kallocryl A
Methylmethacrylate
Methacrylate Methyl Monomer
Zimmer Bone Cement

The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.


Regulatory Elements, Transcriptional
Element, Transcriptional Regulatory
Elements, Transcriptional Regulatory
Regulatory Element, Transcriptional
Transcriptional Regulatory Elements
Transcriptional Regulatory Element

Nucleotide sequences of a gene that are involved in the regulation of GENETIC TRANSCRIPTION.


Androst-5-ene-3,17-diol
Delta 5-Androstenediol
Androst-5-ene-3 beta,17 beta-Diol
Hermaphrodiol
delta 5-Androstene-3 beta,17 beta-Diol
5-Androstene-3,17-diol
Bisexovister
Androstenediol
5-Androstene-3beta-17beta-Diol

An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).


Notch2 Receptor
Notch2 Protein
Receptor, Notch2

A notch receptor that plays an important role in CELL DIFFERENTIATION in a variety of cell types. It is the preferentially expressed notch receptor in mature B-LYMPHOCYTES.


Intraoperative computer-assisted 3D navigation and guidance system generally used in neurosurgery for tracking surgical tools and localize them with respect to the patient's 3D anatomy. The pre-operative diagnostic scan is used as a reference and is transferred onto the operative field during surgery.


A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.


A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis.


A disease of the pilosebaceous unit, presenting clinically as grouped follicular papules or plaques with associated hair loss. It is caused by mucinous infiltration of tissues, and usually involving the scalp, face, and neck. It may be primary (idiopathic) or secondary to mycosis fungoides or reticulosis.


Central Sensitization
Central Nervous System Sensitization

An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).


Antineoplastic Antimetabolites
Antimetabolites, Antineoplastic

Antimetabolites that are useful in cancer chemotherapy.


Dibucaine Nupercaine Nupercainal Sovcaine Cincain Cinchocaine

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)


1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.


Neoplasms, Adnexal and Skin Appendage
Adnexal and Skin Appendage Neoplasms

Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.


hfq Gene Product
Host Factor 1
Host Factor Q
Host Factor 1 Protein

An integration host factor that was originally identified as a bacterial protein required for the integration of bacteriophage Q beta (ALLOLEVIVIRUS). Its cellular function may be to regulate mRNA stability and processing in that it binds tightly to poly(A) RNA and interferes with ribosome binding.


Chondroitin Sulfate Proteoglycan
Proteochondroitin Sulfates
Proteochondroitin Sulfate
Chondroitin Sulfate Proteoglycans

Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.


Zona Pellucida Glycoproteins
Zona Pellucida Glycoprotein-2
ZP Proteins
Zona Pellucida Glycoprotein-1
Zona Pellucida Glycoprotein-3
Sperm Receptors

A glycoprotein of the ZONA PELLUCIDA that is essential for sperm binding and formation of the zona matrix.


A malignant tumor originating from the endothelial cells of lymphatic vessels. Most lymphangiosarcomas arise in an arm secondary to radical mastectomy but they sometimes complicate idiopathic lymphedema. The lymphedema has usually been present for 6 to 10 years before malignant changes develop. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)


Harassment, Sexual
Sexual Harrassment
Sexual Harassment

A form of discrimination in the workplace which violates the Civil Rights Act of 1964. Offensive sexual conduct may include unwelcome advances, comments, touching, questions about marital status and sex practices, etc. Both men and women may be aggressors or victims. (Slee and Slee, Health Care Terms, 2d ed, p.404). While civil rights legislation deals with sexual harassment in the workplace, the behavior is not restricted to this; it may take place outside the work environment: in schools and colleges, athletics, and other social milieus and activities.


Sponge (Zoology)
Sponges (Zoology)
Porifera
Sponges
Demospongiae

The largest class in the phylum PORIFERA, comprised of over 95% of all living species. Most have siliceous spicules and/or a fibrous skeleton.


A plant genus of the family ARACEAE. Members contain acrid calcium oxalate and LECTINS. Polynesians prepare the root into poi. Common names of Taro and Coco Yam (Cocoyam) may be confused with other ARACEAE; XANTHOSOMA; or with common yam (DIOSCOREA).


Molar, Fourth
Tooth, Supernumerary
Teeth, Supernumerary

An extra tooth, erupted or unerupted, resembling or unlike the other teeth in the group to which it belongs. Its presence may cause malposition of adjacent teeth or prevent their eruption.


Guanosine Diphosphate
Guanosine 5'-Diphosphate
GDP
Guanosine 5'-Trihydrogen Diphosphate

A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.


Photoinitiators, Dental
Resin Photoinitiators, Dental

Chemical compound used to initiate polymerization of dental resins by the use of DENTAL CURING LIGHTS. It absorbs UV light and undergoes decomposition into free radicals that initiate polymerization process of the resins in the mix. Each photoinitiator has optimum emission spectrum and intensity for proper curing of dental materials.


National Cancer Institute (U.S.)
National Cancer Institute
NCI (US)

Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.


Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION).


Cerebellopontile Angle
Cerebellopontine Angle

Junction between the cerebellum and the pons.


Internal Ophthalmoplegia
External Ophthalmoplegia
Oculomotor Paralysis
Ophthalmoplegia
Ophthalmoparesis

Paralysis of one or more of the ocular muscles due to disorders of the eye muscles, neuromuscular junction, supporting soft tissue, tendons, or innervation to the muscles.


UMLS
Metathesaurus
Unified Medical Language System

A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.


A short pro-domain caspase that is almost exclusively expressed in the EPIDERMIS and may play a role in the differentiation of epidermal KERATINOCYTES.


Microenterprise
Small Business
Medium-Sized Business

For-profit enterprise with moderate number of employees and generally moderate volume of sales.


Prospidine
Prospidium Chloride
Prospidium
Prospidin

An antineoplastic dispiropiperazine derivative.


delta Immunoglobulin Heavy Chains
Immunoglobulin delta-Chains
Immunoglobulin delta-Chain
delta-Chain Immunoglobulins
Ig delta Chains
Immunoglobulins, delta-Chain
delta Immunoglobulin Heavy Chain

The class of heavy chains found in IMMUNOGLOBULIN D. They have a molecular weight of approximately 64 kDa and they contain about 500 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region.


Nutritive oil extracted from the fleshy mesocarp of the fruit of the African palm tree, Elaeis guineensis.


Objectives, Organizational
Goals, Organizational
Organizational Goals
Organizational Objectives

The purposes, missions, and goals of an individual organization or its units, established through administrative processes. It includes an organization's long-range plans and administrative philosophy.


National Institute on Aging
National Institute on Aging (U.S.)
NIA (US)

Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research into the nature of the aging process and diseases associated with the later stages of life. The Institute was established in 1974.


An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.


Self-Assessment
Assessment, Self
Self Assessment
Self-Criticism
Self Assessment (Psychology)

Critical or analytical evaluation of self.


Injuries to the wrist or the wrist joint.


The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).


Herpes Simplex, Genital
Genital Herpes
Herpes Genitalis
Herpes Simplex Virus Genital Infection

Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.


Group IA Phospholipases A2
Phospholipases A2, Group IA

A subclass of group I phospholipases A2 that includes enzymes isolated from ELAPID VENOMS.


Familial Ebstein's Anomaly
Ebstein Anomaly
Ebstein's Malformation
Ebstein's Anomaly

A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and posterior leaflets being attached to the wall of the RIGHT VENTRICLE. It is characterized by a huge RIGHT ATRIUM and a small and less effective right ventricle.


Exposure, Dental Pulp
Pulp Exposure, Dental
Dental Pulp Exposure

The result of pathological changes in the hard tissue of a tooth caused by carious lesions, mechanical factors, or trauma, which render the pulp susceptible to bacterial invasion from the external environment.


Cytidylic Acid
2'-CMP
CMP
Cytidylic Acids
Cytidine Monophosphate
3'-CMP

Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.


Semaphorin III Receptor
Npn-1 Protein
Sema III Receptor
A5 Antigen
NRP1 Protein
Neuropilin-1

A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.


Bivalent Meningococcal Vaccine
Meningococcal Vaccines
Menactra
Tetravalent Meningococcal Vaccine
Menveo
Menomune
Meningococcal Vaccine
Meningococcal Polysaccharide Vaccine

Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.


Molybdoferredoxin
Molybdenum-Iron Protein
MoFe Protein
Iron-Molybdenum Cofactor
FeMo Cofactor

A non-heme iron-sulfur protein isolated from Clostridium pasteurianum and other bacteria. It is a component of NITROGENASE, which is active in nitrogen fixation, and consists of two subunits with molecular weights of 59.5 kDa and 50.7 kDa, respectively.


Economic Burden of Disease
Burden of Illness
Disease Costs
Cost of Sickness
Sickness Cost
Cost of Disease
Disease Cost
Cost of Illness
Costs of Disease

The personal cost of disease which may be economic, social, or psychological. The cost of illness may be reflected in absenteeism, productivity, response to treatment, peace of mind, or QUALITY OF LIFE. It differs from HEALTH CARE COSTS, the societal cost of providing services related to the delivery of health care.


Department of Defense (U.S.)
United States Dept. of Defense
United States Department of Defense

A cabinet department in the Executive Branch of the United States Government whose mission is to provide the military forces needed to deter WARFARE and to protect the security of our country.


Small Nuclear Ribonucleoprotein Particle

Highly conserved nuclear RNA-protein complexes that function in RNA processing in the nucleus, including pre-mRNA splicing and pre-mRNA 3'-end processing in the nucleoplasm, and pre-rRNA processing in the nucleolus (see RIBONUCLEOPROTEINS, SMALL NUCLEOLAR).


Therapy, Socioenvironmental
Socioenvironmental Therapy

Therapy whose primary emphasis is on the physical and social structuring of the environment to promote interpersonal relationships which will be influential in reducing behavioral disturbances of patients.


Works that include publications such as reports, theses, conference papers, translations and limited circulation government documents which are not normally available through commercial publication sources. (LCSH)


Suppressor of Cytokine Signaling 3 Protein

Suppressor of Cytokine Signaling Protein 3

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.


Direct-to-Consumer Marketing
Direct-to-Consumer Advertising

Advertising that directly targets consumers of certain products such as pharmaceuticals.


Travel by means of an airplane, helicopter, or balloon.


Angiography, Digital Subtraction
Digital Subtraction Angiography
Subtraction Angiography, Digital

A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.


A species of gram-negative bacteria parasitic on HORSES and DONKEYS causing GLANDERS, which can be transmitted to humans.


A member of the vesicle-associated membrane protein family involved in the MEMBRANE FUSION of TRANSPORT VESICLES to their target membrane.


Nucleotide Oligomerization Domain 1 Protein

A NOD-signaling adaptor protein that contains a C-terminal leucine-rich domain which recognizes bacterial PEPTIDOGLYCAN. It signals via an N-terminal caspase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. It plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM.


Simple amine found in the brain. It may be modulator of sympathetic functions. Its derivatives are adrenergic agonists and antagonists. It is also used in chemical industry.


Analytical Chemistry Methods
Chemistry Techniques, Analytical
Analytical Chemistry Techniques

Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.


World Trade Center Attack, 2001
September 11 Terrorist Attacks, 2001
September 11 Terrorist Attacks
9-11-2001 Attack

Terrorism on September 11, 2001 against targets in New York, the Pentagon in Virginia, and an aborted attack that ended in Pennsylvania.