Apoptosomes
Apoptosome
Apoptosomal Protein Complex

Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.


Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolase Inhibitors
Phosphodiesterase Antagonists
Antiphosphodiesterases

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.


Sheep Contagious Pustular Dermatitis Virus

Contagious Pustular Dermatitis Virus of Sheep

The type species of PARAPOXVIRUS which causes a skin infection in natural hosts, usually young sheep. Humans may contract local skin lesions by contact. The virus apparently persists in soil.


Celite 545
Celite
Kieselguhr
Diatomaceous Earth
Chromosorb P
Infusorial Earth
Celite 560

A form of SILICON DIOXIDE composed of skeletons of prehistoric aquatic plants which is used for its ABSORPTION quality, taking up 1.5-4 times its weight in water. The microscopic sharp edges are useful for insect control but can also be an inhalation hazard. It has been used in baked goods and animal feed. Kieselguhr is German for flint + earthy sediment.


Retinaldehyde
Vitamin A Aldehyde
Axerophthal
11-cis-Retinal
Retinal
Retinene

A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.


Gastrointestinal Endoscopes
Endoscopes, Gastrointestinal

Instruments for the visual examination of the interior of the gastrointestinal tract.


Delivery of the FETUS and PLACENTA under the care of an obstetrician or a health worker. Obstetric deliveries may involve physical, psychological, medical, or surgical interventions.


11-beta-Hydroxysteroid Dehydrogenase Type 1

11 beta-Hydroxysteroid Dehydrogenase Type 1

11beta-Hydroxysteroid Dehydrogenase Type 1

A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.


SRY Sex-Determining Region Protein
Sex-Determining Region Y Protein
Testis-Determining Factor

A transcription factor that plays an essential role in the development of the TESTES. It is encoded by a gene on the Y chromosome and contains a specific HMG-BOX DOMAIN that is found within members of the SOX family of transcription factors.


Nucleoside Transporter
Nucleoside Transport Proteins

Proteins involved in the transport of NUCLEOSIDES across cellular membranes.


Trichlorfon Dylox Metriphonate Metrifonate Neguvon Foschlor Chlorofos Chlorophos Trichlorphon Ricifon Bilarcil Dipterex

An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed)


A plant genus of the family AIZOACEAE. It is a native of Africa and widely planted for erosion control to stabilize soil along roadsides and beaches.


Fibril-Associated Collagens With Interrupted Triple Helices

A family of non-fibrillar collagens that interact with FIBRILLAR COLLAGENS. They contain short triple helical domains interrupted by short non-helical domains and do not form into collagen fibrils.


Child Daycare Centers
Child Day Care Centers
Daycare Centers for Children
Day Care Centers for Children

Facilities which provide care for pre-school and school-age children.


Familial pseudoaldosteronism characterized by autosomal dominant inheritance of hypertension with HYPOKALEMIA; ALKALOSIS; RENIN and ALDOSTERONE level decreases. It is caused by mutations in EPITHELIAL SODIUM CHANNELS beta and gamma subunits. Different mutations in the same EPITHELIAL SODIUM CHANNELS subunits can cause PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL DOMINANT.


A strain of PRIMATE T-LYMPHOTROPIC VIRUS 3 that is genetically similar to STLV-3.


Dontisanin
Ananase
Bromelain-POS
Mucozym
Traumanase
Debrase
Extranase
Bromelain
Proteozym
Bromelins
Dayto Anase
Bromelains
Bromelin

Gel dressing used for debridement (cleaning) of deep burns in hospitalized patients.


A chlorinated anilide that is used as an herbicide.


Drug Resistance, Multiple, Bacterial
Multiple Antibacterial Drug Resistance

The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).


Climate Therapy
Thalassotherapy
Climatotherapy

The therapeutic use of seaside resorts; includes treatment by sea air, sea voyages, and sea bathing.


GI Tract
Gastrointestinal Tract
Digestive Tract

Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).


Non-Sexual Harassment
Harassment, Nonsexual
Harassment, Non-Sexual
Nonsexual Harassment

The act of systematic and/or continuous unwanted and irritating actions of a non-sexual nature, by a party or group against another. This behavior may include threats, BULLYING, taunts, blackmail, and demands.


Atresia, Anal
Anus, Imperforate
Anal Atresia

A congenital abnormality characterized by the persistence of the anal membrane, resulting in a thin membrane covering the normal ANAL CANAL. Imperforation is not always complete and is treated by surgery in infancy. This defect is often associated with NEURAL TUBE DEFECTS; MENTAL RETARDATION; and DOWN SYNDROME.


A type C phospholipase specific for GLYCOSYLPHOSPHATIDYLINOSITOLS. It plays a role in the breaking of GPI MEMBRANE ANCHORS.


Hyacinth, Water
Eichhornia
Water Hyacinth

A plant genus of the family PONTEDERIACEAE that is used as a biological filter for treating wastewater.


Plastids that can develop into CHLOROPLASTS.


5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine.


Receptor, Galanin, Type 1
Galanin-1 Receptor
GALR1 Galanin Receptor
Galanin Receptor 1

The most abundant galanin receptor subtype. It displays a high affinity for the full-length form of GALANIN.


Neurological Diagnostic Techniques
Techniques, Neurological Diagnostic
Diagnostic Technic, Neurological
Neurological Diagnostic Technique
Neurological Diagnostic Technic
Technics, Neurological Diagnostic
Diagnostic Techniques, Neurological
Diagnostic Technique, Neurological
Diagnostic Technics, Neurological
Neurological Diagnostic Technics
Technic, Neurological Diagnostic
Diagnostic Techniques, Neurologic
Technique, Neurological Diagnostic
Diagnostic Technics, Neurologic

Methods and procedures for the diagnosis of diseases of the nervous system, central and peripheral, or demonstration of neurologic function or dysfunction.


Home Hemodialysis
Renal Dialysis, Home
Hemodialysis, Home

Long-term maintenance hemodialysis in the home.


Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc.


Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.


CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).


Glycoprotein gp135
Contactin 1
Neural Cell Surface Protein F3

A contactin subtype that is predominantly expressed in the CEREBELLUM; HIPPOCAMPUS; NEOCORTEX; and HYPOTHALAMUS.


P1 Purinoceptor Antagonists
Adenosine Receptor Antagonists
Purinergic P1 Receptor Antagonists

Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.


The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.


The visual representation of data via a manufactured system.


Hemorrhage, Subdural, Acute
Hematoma, Subdural, Acute
Subdural Hematoma, Acute

Accumulation of blood in the SUBDURAL SPACE with acute onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.


Reproductive Sterility in Plants
Plant Infertility
Sterility, Reproductive, Plants
Reproductive Sterility, Plants
Infertility, Plant

The failure of PLANTS to complete fertilization and obtain seed (SEEDS) as a result of defective POLLEN or ovules, or other aberrations. (Dict. of Plant Genet. and Mol. Biol., 1998)


A radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4)


The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.


A genus of QUAIL, in the family Odontophoridae, comprised of at least four different species of bobwhites.


Glucitol
Medevac
klysma Sorbit
Sorbitol
Yal
Sorbilax

A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.


Hospital Hemodialysis Units
Hemodialysis Units, Hospital
Renal Dialysis Units, Hospital

Hospital units in which care is provided the hemodialysis patient. This includes hemodialysis centers in hospitals.


Trihexosyl Ceramides
Ceramide Trihexosides
Trihexosylceramides

Glycosphingolipids which contain as their polar head group a trisaccharide (galactose-galactose-glucose) moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in ceramide trihexosidase, is the cause of angiokeratoma corporis diffusum (FABRY DISEASE).


Intersectoral Cooperation
Intersectoral Collaboration

Cooperative actions and ventures among health and health-related groups and organizations intended to improve health outcomes.


Dithiothreitol
Sputolysin
Cleland's Reagent
Cleland Reagent

A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.


Neuromuscular Blockers
Neuromuscular Blocking Agents

Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.


Asthma
Asthma, Bronchial
Bronchial Asthma

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).


A condition caused by a deficiency or a loss of melanin pigmentation in the epidermis, also known as hypomelanosis. Hypopigmentation can be localized or generalized, and may result from genetic defects, trauma, inflammation, or infections.


Alkaptonuria
Homogentisic Acid Oxidase Deficiency
Alcaptonuria
Homogentisic Acidura

An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.


Bilateral Multicystic Dysplastic Kidneys

Unilateral Multicystic Dysplastic Kidney

A nongenetic defect due to malformation of the KIDNEY which appears as a bunch of grapes with multiple renal cysts but lacking the normal renal bean shape, and the collection drainage system. This condition can be detected in-utero with ULTRASONOGRAPHY.


Cerebral Intraventricular Haemorrhage
Cerebral Intraventricular Hemorrhage

Bleeding within the CEREBRAL VENTRICLES. It is associated with intraventricular trauma, aneurysm, vascular malformations, hypertension and in VERY LOW BIRTH WEIGHT infants.


Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.


Titration Skin Test, End-Point
Serial Dilution End-Point Titration
Serial Dilution Endpoint Titration
Rinkel Serial Dilution Titration
Skin End-Point Titration
Skin Test End-Point Titration
Skin Test Endpoint Titration
Titration Skin Test, Endpoint

A quantitative form of intradermal testing for the relative allergenicity of a substance. It is used to determine the amount of an allergen that will be tolerated in ALLERGEN IMMUNOTHERAPY.


M Creatine Kinase
MM Creatine Kinase
Creatine Kinase, MM Form
Muscle Creatine Kinase

An isoenzyme of creatine kinase found in the MUSCLE.


A plant genus of the family ROSACEAE that is the source of an edible fruit. Members contain TRITERPENES.


A benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy.


Evoked Potentials, Visual
Visual Evoked Response

The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.


Prepaid Group Practice
Group Practice, Prepaid

An organized group of three or more full-time physicians rendering services for a fixed prepayment.


Procedures, Otologic Surgical
Otologic Surgical Procedures
Otologic Surgical Procedure
Surgical Procedure, Otologic
Surgical Procedures, Otologic
Procedure, Otologic Surgical

Surgery performed on the external, middle, or internal ear.


Fc epsilon Receptors
epsilon Fc Receptors
Fc epsilon RI
IgE Receptors
CD 23 Antigens
CD23 Antigen
Antigens, CD23
Immunoglobulin E Receptor
Fc Receptors, epsilon
Receptors, IgE
CD23 Antigens
Fc epsilon RII
Receptors, Fc epsilon

Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).


Km Allotypes
Ig Km Allotypes
Immunoglobulin Km Allotypes
Inv Allotypes
Immunoglobulin Inv Allotypes
Allotypes, Immunoglobulin Inv

Allelic variants of the kappa light chains (IMMUNOGLOBULIN KAPPA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN LIGHT CHAIN GENES.


Corynebacterium Diphtheriae Toxin
Diphtheria Toxin
Toxin, Corynebacterium Diphtheriae

An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.


Splicing Factor Proline-Glutamine Rich Protein

Polypyrimidine Tract-Binding Protein-Associated Splicing Factor

An RNA splicing factor that also binds DNA. It is essential for pre-mRNA spicing in the formation of early SPLICEOSOMES and catalytic step II. It binds specifically to polypyrimidine tracts in INTRONS and is involved in the regulation of ALTERNATIVE SPLICING by SIGNAL TRANSDUCTION PATHWAYS.


Circulating Endothelial Progenitor Cells

Cells derived from BONE MARROW that circulate in the adult bloodstream and possess the potential to proliferate and differentiate into mature ENDOTHELIAL CELLS.


Neuron-Glia Adhesion Molecules
Neuron-Glia Cell Adhesion Molecules
Cell Adhesion Molecules, Neuron-Glia
G4 Antigen
Ng-CAM

Cell adhesion molecules that mediate neuron-neuron adhesion and neuron-astrocyte adhesion. They are expressed on neurons and Schwann cells, but not astrocytes and are involved in neuronal migration, neurite fasciculation, and outgrowth. Ng-CAM is immunologically and structurally distinct from NCAM.


Census
Censuses
Census Methods
Microcensus

Enumerations of populations usually recording identities of all persons in every place of residence with age or date of birth, sex, occupation, national origin, language, marital status, income, relation to head of household, information on the dwelling place, education, literacy, health-related data (e.g., permanent disability), etc. The census or "numbering of the people" is mentioned several times in the Old Testament. Among the Romans, censuses were intimately connected with the enumeration of troops before and after battle and probably a military necessity. (From Last, A Dictionary of Epidemiology, 3d ed; Garrison, An Introduction to the History of Medicine, 4th ed, p66, p119)


M. fuscata
Japanese Macaque
Macaca fuscata
Macaca fuscata fuscata
Macaca fuscata yakui
Japanese Monkey
Snow Monkey
Monkey, Japanese

A species of the genus MACACA characterized by red naked face. M. fuscata is primarily ground-dwelling in forest and mountains often near hot springs in Japan.


Activating Transcription Factors
ATF Transcription Factors

Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.


A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.


Glycogen-Synthase-D Phosphatase
Glycogen Synthetase Phosphatase
Protein Phosphatase G

An enzyme that catalyzes the conversion of phosphorylated, inactive glycogen synthase D to active dephosphoglycogen synthase I. EC 3.1.3.42.


A synthetic steroid with anabolic and androgenic properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188)


Grafting, Liver
Hepatic Transplantation
Transplantation, Hepatic
Liver Transplantation
Liver Transplant
Transplantation, Liver

The transference of a part of or an entire liver from one human or animal to another.


Keratins that form into a beta-pleated sheet structure. They are principle constituents of the corneous material of the carapace and plastron of turtles, the epidermis of snakes and the feathers of birds.


Congenital Limb Deformities
Limb Deformities, Congenital

Congenital structural deformities of the upper and lower extremities collectively or unspecified.


Vascular Endothelial Growth Factor C
Vascular Endothelial Growth Factor-C
VEGF-C

A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.


Bone Sialoprotein I
Bone Sialoprotein 1
Secreted Phosphoprotein 1
Sialoprotein 1
Osteopontin
Uropontin


The discharge of substances from the blood supply via diffusion into the SALIVA from the ORAL MUCOSA or from the SALIVARY GLANDS.


Exosome Multienzyme Ribonuclease Complex

An intracellular ribonucleolytic protein complex that participates in POSTRANSCRIPTIONAL RNA PROCESSING and RNA DEGRADATION.


Ferricytochrome b5
Cytochrome b5
Cytochrome b-5
Apocytochrome b5
Cytochromes b5

Cytochromes of the b group that are found bound to cytoplasmic side of ENDOPLASMIC RETICULUM. They serve as electron carrier proteins for a variety of membrane-bound OXYGENASES. They are reduced by the enzyme CYTOCHROME-B(5) REDUCTASE.


RNA, Transfer, His
tRNA(His)
Histidine-Specific tRNA
tRNAHis
Transfer RNA, His

A transfer RNA which is specific for carrying histidine to sites on the ribosomes in preparation for protein synthesis.


Thyroid Storm
Crisis, Thyrotoxic
Thyroid Crisis
Thyrotoxic Crisis
Thyrotoxic Storm

A dangerous life-threatening hypermetabolic condition characterized by high FEVER and dysfunction of the cardiovascular, the nervous, and the gastrointestinal systems.


Gases, Inert
Group 18 Elements
Rare Gases
Gases, Rare
Noble Gases

Elements that constitute group 18 (formerly the zero group) of the periodic table. They are gases that generally do not react chemically.


A genus of snakes of the family VIPERIDAE. About 30 species are currently recognized, found in southeast Asia and adjacent island chains. The Okinawa habu frequently enters dwellings in search of rats and mice; the Chinese habu is often found in suburban and agricultural areas. They are quite irritable. (Moore: Poisonous Snakes of the World, 1980, p136)


A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.


Life History Stages
Life Cycle Stages
Life Cycle

The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.


A benign neoplasm derived from epithelial cells of sweat glands. (Stedman, 25th ed)


Dominance Hierarchy
Dominance, Social
Social Dominance

Social structure of a group as it relates to the relative social rank of dominance status of its members. (APA, Thesaurus of Psychological Index Terms, 8th ed.)


Tocodynamometry
Tocography
Tocograms
Uterine Monitoring

Measurement or recording of contraction activity of the uterine muscle. It is used to determine progress of LABOR, OBSTETRIC and assess status of pregnancy. It is also used in conjunction with FETAL MONITORING to determine fetal response to stress of maternal uterine contractions.


Interleukin-18 Receptor Accessory Protein

A subunit of the interleukin-18 receptor that plays a role in receptor signaling by association of its cytoplasmic domain with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88.


The capability of producing yolk-filled eggs that hatch within the body, so that the young are born alive, but without placental attachment. This applies to certain species of REPTILES and FISHES.


N-Type Voltage-Dependent Calcium Channels

CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their voltage dependence.


Regulatory Factor X
RFX1 Protein
MHC Class II Regulatory Factor RFX
RFX1 Transcription Factor
RF-X Binding Protein
X Box Binding Protein (RF-X)
RFX Regulatory Factor
Regulatory Factor X1
Regulatory Factor-X

A regulatory factor X transcription factor that is required for the expression of MHC CLASS II GENES. It also binds to inverted repeats of HEPATITIS B VIRUS DNA and is required for viral gene expression. RFX1 functions as a monomer or heterodimer with other RFX transcription factors.


An undecenyl THIOUREA which may have topical anti-inflammatory activity.


Ehrlichia sennetsu
Neorickettsia sennetsu

A species of gram-negative bacteria in the genus NEORICKETTSIA, family ANAPLASMATACEAE, causing Sennetsu fever and found in the FAR EAST and SOUTHEAST ASIA.


Non-Small-Cell Lung Carcinoma
Carcinoma, Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung
Nonsmall Cell Lung Cancer
Non-Small Cell Lung Cancer

A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.


Sialylated Lewis(a) blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.


A mushroom, Ganoderma lucidum, of the POLYPORALES order of basidiomycetous fungi. It has long been used in traditional Chinese medicine in various forms.


A fatal disease of the nervous system in sheep and goats, characterized by pruritus, debility, and locomotor incoordination. It is caused by proteinaceous infectious particles called PRIONS.


Immunological Capping
Capping, Immunologic
Immunologic Capping

An energy dependent process following the crosslinking of B CELL ANTIGEN RECEPTORS by multivalent ligands (bivalent anti-antibodies, LECTINS or ANTIGENS), on the B-cell surface. The crosslinked ligand-antigen receptor complexes collect in patches which flow to and aggregate at one pole of the cell to form a large mass - the cap. The caps may then be endocytosed or shed into the environment.


Ganglia, Basal
Basal Nuclei
Basal Nuclear Complex
Basal Ganglia
Ganglion, Basal

Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.


Sciatica, Bilateral
Neuralgia, Sciatic
Sciatica
Sciatic Neuralgia

A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.


Sexually Transmitted Diseases, Bacterial

Bacterial diseases transmitted or propagated by sexual conduct.


Tyrosine Protein Kinases
Protein-Tyrosine Kinases
Protein-Tyrosine Kinase
Tyrosine Protein Kinase
Tyrosine-Specific Protein Kinases
Tyrosine Kinase
Tyrosine-Specific Protein Kinase
Tyrosylprotein Kinase

Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.


MVV (Ventilation)
Maximal Breathing Capacity
Maximal Voluntary Ventilation

Measure of the maximum amount of air that can be breathed in and blown out over a sustained interval such as 15 or 20 seconds. Common abbreviations are MVV and MBC.


An isotonic solution; the base contains SODIUM CHLORIDE; POTASSIUM CHLORIDE; and CALCIUM CHLORIDE. Other chemicals, such as SODIUM BICARBONATE or acetate salts may be added, as needed for pH buffering, or as an energy source.


Enriched Food
Food, Fortified
Food, Supplemented

Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)


Stx1 Protein
Shiga-Like Toxin I
Vero Cytotoxin VT1
SLTI
Verocytotoxin 1
Verotoxin I
Shiga Toxin 1
VT1 Cytotoxin
SLT-I

A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It is closely related to SHIGA TOXIN produced by SHIGELLA DYSENTERIAE.


The perceiving of attributes, characteristics, and behaviors of one's associates or social groups.


Passive-Dependent Personality
Dependent Personality Disorder
Personality Disorder, Dependent

A personality disorder characterized by a pervasive and excessive need to be taken care of that leads to submissive and clinging behavior and fears of separation, beginning by early adulthood and present in a variety of contexts. (From DSM-IV, 1994)


G-Protein gamma Subunit
GTP-Binding Protein gamma Subunits
GTP-Binding Protein gamma Subunit

Heterotrimeric GTP-binding protein subunits that tightly associate with GTP-BINDING PROTEIN BETA SUBUNITS. A dimer of beta and gamma subunits is formed when the GTP-BINDING PROTEIN ALPHA SUBUNIT dissociates from the GTP-binding protein heterotrimeric complex. The beta-gamma dimer can play an important role in signal transduction by interacting with a variety of second messengers.


Projection neurons in the CEREBRAL CORTEX and the HIPPOCAMPUS. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.


A plant family of the order Pinales, class Pinopsida, division Tracheophyta. They are mainly resinous, aromatic evergreen trees.


FK506 Binding Protein 12-Rapamycin Associated Protein 1

A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.


Steel Factor
kit Ligand
Mast Cell Growth Factor
c-kit Ligand
Stem Cell Factor

A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.


Hospitals providing medical care to veterans of wars.


CD121a Antigens
Antigens, CDw121a
Interleukin-1 Receptors Type I
Receptor Type I, Interleukin-1
Receptors, Interleukin-1 Type I
Interleukin-1 Receptor Type I

An interleukin-1 receptor subtype that is involved in signaling cellular responses to INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The binding of this receptor to its ligand causes its favorable interaction with INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN and the formation of an activated receptor complex.


Psychology, Positive
Positive Psychology

The scientific study of the strengths that enable individuals and communities to thrive. It is founded on the belief that people want to lead meaningful and fulfilling lives, to cultivate what is best within themselves, and to enhance their experiences of love, work, and play. (https://ppc.sas.upenn.edu/)


Monkeypoxvirus
Monkey Pox Virus
Monkeypox virus

A species of ORTHOPOXVIRUS causing an epidemic disease among captive primates.


Intercalating Ligands
Intercalating Agents
Intercalators
Intercalative Compounds

Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.


Fanconi Anemia Group D2 Complementing Protein

Fanconi Anemia Complementation Group D2 Protein

A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.


An allylic compound that acts as a suicide inactivator of CYTOCHROME P450 by covalently binding to its heme moiety or surrounding protein.


U7 Small Nuclear Ribonucleoproteins
Small Nuclear Ribonucleoproteins, U7
U7 snRNP
Ribonucleoprotein, U7 Small Nuclear

This ribonucleoprotein particle, composed of U7 snRNA, Sm core protein, and U7 snRNP-specific proteins, is involved in the 3'end processing of histone premessenger RNAs.


Reconstructive Surgical Procedures, Neck

Reconstructive surgical procedures in the NECK region to restore or improve form and function.


Thoracic Radiography
Radiography, Thoracic

X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.


Adrenomimetics
Adrenergic Agonist
Adrenergic Agonists
Adrenergic Receptor Agonist
Receptor Agonists, Adrenergic
Adrenergic Receptor Agonists

Drugs that bind to and activate adrenergic receptors.


Carbinol
Wood Alcohol
Alcohol, Methyl
Sodium Methoxide
Methanol

A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.


Caspase-1 Dependent Cell Death
Inflammatory Apoptosis
Pyroptotic Cell Death
Pyroptosis

Type of programmed cell death associated with infection by intracellular pathogens. It is characterized by INFLAMMASOME formation; activation of CASPASE 1; and CYTOKINES mediated inflammation.


A growth differentiation factor that plays a role in the neural differentiation, specifically in the retinal development of the EYE.


Arthroplasty, Replacement, Disc
Total Disc Arthroplasty
Artificial Disc Replacement
Total Disk Arthroplasty
Total Disk Replacement
Arthroplasty, Replacement, Disk
Artificial Disk Replacement
Total Disc Replacement

The replacement of intervertebral discs in the spinal column with artificial devices. The procedure is done in the lumbar or cervical spine to relieve severe pain resulting from INTERVERTEBRAL DISC DEGENERATION.


Persons involuntarily controlled by another and exploited for forced or compulsory work or service.


HCT 116 Cells
HCT-116 Cells
HCT116 Cells


Amyloid A4 Protein Precursor
Amyloid beta-Protein Precursor
beta-Amyloid Protein Precursor
Amyloid beta Precursor Protein
Amyloid Protein Precursor
Protease Nexin 2
Protease Nexin II

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.


Tongue Tie
Partial Ankyloglossia
Ankyloglossia

A severe congenital restriction of TONGUE movement, resulting from fusion or adherence of the tongue to the floor of the mouth. In partial ankyloglossia (tongue-tie) the LINGUAL FRENUM is abnormally short, or is attached too close to the tip of the tongue. OMIM: 106280


An insoluble support for an ANTIGEN or ANTIBODIES that is used in AFFINITY CHROMATOGRAPHY to adsorb the homologous antibody or antigen from a mixture. Many different substances are used, among them SEPHAROSE; GLUTARALDEHYDE; copolymers of ANHYDRIDES; polyacrylamides, etc.


Phosphofructo-1-kinase Isozyme C
6-Phosphofructokinase, Platelet Type
Phosphofructokinase-1, Type C

An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In the humans, 6-phosphofructose-1-kinase isozyme C is found in platelets, brain, heart, kidney, colon and testis. This isozyme C can exist as the homotetramer of C subunits (P subunits), or heterotetramer of C type and L type subunits.


Facial Neuralgia
Facial Pain Syndromes
Craniofacial Pain Syndromes
Myofacial Pain Syndromes
Sphenopalatine Neuralgia

Neuralgic syndromes which feature chronic or recurrent FACIAL PAIN as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions.


Discectomy, Percutaneous
Nucleotomy, Percutaneous
Diskectomy, Percutaneous

Percutaneous excision of a herniated or displaced INTERVERTEBRAL DISC by posterolateral approach, always remaining outside the spinal canal. Percutaneous nucleotomy was first described by Hijikata in Japan in 1975. In 1985 Onik introduced automated percutaneous nucleotomy which consists in percutaneous aspiration of the nucleus pulposus. It is carried out under local anesthesia, thus reducing the surgical insult and requiring brief hospitalization, often performed on an outpatient basis. It appears to be a well-tolerated alternative to surgical diskectomy and chymopapain nucleolysis.


A change or shift in personnel due to reorganization, resignation, or discharge.


Neonatal Alloimmune Thrombocytopenia
Thrombocytopenia, Neonatal Alloimmune
Neonatal Thrombocytopenia

A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.


Flow Injection Analysis
Analysis, Flow Injection

The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.


Grants
Financing, Organized
Organized Financing
Community Financing


Deficiency, Vitamin D
Vitamin D Deficiency

A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)


Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.


Spectroscopy, Mossbauer
Nuclear Gamma Resonance Spectroscopy
Mossbauer Spectroscopy

A spectroscopic technique which uses the Mossbauer effect (inelastic scattering of gamma radiation resulting from interaction with heavy nuclei) to monitor the small variations in the interaction between an atomic nucleus and its environment. Such variations may be induced by changes in temperature, pressure, chemical state, molecular conformation, molecular interaction, or physical site. It is particularly useful for studies of structure-activity relationship in metalloproteins, mobility of heavy metals, and the state of whole tissue and cell membranes.


Mussels, Common
Mytilus edulis
Mussel, Blue
Mussel, Common
Mussels, Blue

A species of mussel in the genus MYTILUS, family MYTILIDAE, class BIVALVIA, known as the common mussel. It has a bluish-black shell and is highly edible.


The venous pressure measured in the PORTAL VEIN.


Gram Positive Bacteria
Gram-Positive Bacteria

Bacteria which retain the crystal violet stain when treated by Gram's method.


Act of listening for sounds within the heart.


Sialic Acid Binding Immunoglobulin-like Lectins

A family of SIALIC ACID binding proteins found in vertebrate species. They are transmembrane proteins which act as cell surface receptors for a variety of sialylated GLYCOCONJUGATES. While a subset of siglec protein subtypes are evolutionarily conserved between mammalian species, there are many others that are species specific.


An oligopeptide isolated from the skin of Physalaemus fuscumaculatus, a South American frog. It is a typical kinin, resembling SUBSTANCE P in structure and action and has been proposed as a sialagogue, antihypertensive, and vasodilator.


A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine cells. It catalyzes the cleavage of C-terminal ARGININE or LYSINE residues from polypeptides and is active in processing precursors of PEPTIDE HORMONES and other bioactive peptides.


Leukemia Virus, Bovine
Bovine Leukemia Virus
BLV
Cattle Leukemia Virus

The type species of DELTARETROVIRUS that causes a form of bovine lymphosarcoma (ENZOOTIC BOVINE LEUKOSIS) or persistent lymphocytosis.


Patey Mastectomy
Mastectomy, Modified Radical
Modified Mastectomy

Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.


The systematic study of the structure and function of the complete set of glycans (the glycome) produced in a single organism and identification of all the genes that encode glycoproteins.


Any operation on the spinal cord. (Stedman, 26th ed)


Venous Stasis Syndrome
Postthrombotic Syndrome

A condition caused by one or more episodes of DEEP VEIN THROMBOSIS, usually the blood clots are lodged in the legs. Clinical features include EDEMA; PAIN; aching; heaviness; and MUSCLE CRAMP in the leg. When severe leg swelling leads to skin breakdown, it is called venous STASIS ULCER.


Sodium-Hydrogen Exchanger 1
Solute Carrier Family 9 Member 1
SLC9A1 Protein
Na(+)-H(+) Exchanger 1

A sodium-hydrogen antiporter expressed by many cell types, especially on the basolateral surfaces of EPITHELIAL CELLS. It functions through an inward sodium ion chemical gradient to eliminate acids (protons) generated by metabolism and regulate intracellular pH. It is highly sensitive to AMILORIDE.


Radiation Protection
Protection, Radiation

Methods and practices adopted to protect against RADIATION.


A genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several PSEUDOPODIA, one of which is dominant at a given time. Reproduction occurs asexually by binary fission.


Urological Diseases
Urinary Tract Diseases
Urologic Diseases

Pathological processes of the URINARY TRACT in both males and females.


Morpholinos
Phosphorodiamidate Morpholino Oligomers
PMO Oligomers
Morpholino Oligonucleotides
MORF Oligomers
Morpholino Oligos

Synthetic analogs of NUCLEIC ACIDS composed of morpholine ring derivatives (MORPHOLINES) linked by phosphorodimidates. One standard DNA nucleic acid base (ADENINE; GUANINE; CYTOSINE; OR THYMINE) is bound to each morpholine ring.


Kava
Kava Kava
Kawa Kawa
Piper methysticum
Kawa

Dried rhizome and roots of Piper methysticum, a shrub native to Oceania and known for its anti-anxiety and sedative properties. Heavy usage results in some adverse effects. It contains ALKALOIDS; LACTONES; kawain, methysticin, mucilage, STARCH, and yangonin. Kava is also the name of the pungent beverage prepared from the plant's roots.


Speech Recognition Software
Voice Recognition Software

Software capable of recognizing dictation and transcribing the spoken words into written text.


Committees, Hospital Ethics
Ethics Committee, Hospital
Ethics Committee, Clinical
Ethics Committees, Hospital
Ethics Committees, Clinical
Clinical Ethics Committee
Committee, Clinical Ethics
Committees, Clinical Ethics
Committee, Hospital Ethics
Hospital Ethics Committee
Clinical Ethics Committees
Hospital Ethics Committees

Hospital or other institutional ethics committees established to consider the ethical dimensions of patient care. Distinguish from ETHICS COMMITTEES, RESEARCH, which are established to monitor the welfare of patients or healthy volunteers participating in research studies.


Fluorocarbon Resins
Fluorocarbon Polymers
Fluorinated Polymers


Doxium
Dobesilate Calcium
Calcium Dobesilate
Calcium Dobesilate (1:1)
2,5-Dihydroxybenzenesulfonic Acid
Dexium
Calcium Dobesilate Monopotassium Salt
Calcium Dobesilate Monoammonium Salt
2,5-Dihydroxybenzenesulfonate
Dobica

A drug used to reduce hemorrhage in diabetic retinopathy.


Corethamid
Nicethamide
Coramine
Nikethamide
Coramin
Nicotinic Diethylamide
Diethylnicotinamid
Nizethamid
Cordiamine

A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)


Fixed Retainer
Bonded Retainer
Permanent Retainer
Fixed Functional Appliances
Orthodontic Appliances, Fixed
Fixed Appliances

ORTHODONTIC APPLIANCES attached to the teeth by adhesive material which cannot be removed from the mouth by the patient. These devices apply force to the teeth and supporting structures, thereby producing changes which control their growth and development.


Services, Dental Health
Dental Health Services
Health Services, Dental

Services designed to promote, maintain, or restore dental health.


Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome

Apc10 is necessary for coactivator-dependent substrate recognition by the anaphase-promoting complex-cyclosome. It binds the Apc2 subunit, which is a part of the catalytic core, and interacts with coactivators Cdh1 or Cdc20 to recruit substrates to the complex.


Organizations which assume the financial responsibility for the risks of policyholders.


RNA Polymerase Sigma Factor H
Sigma Element
Minor Sigma Factor
Sigma Initiation Factor
Sigma Factor
Sigma Subunit

A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.


Receptors, Lysophospholipid
Lysophospholipid Receptors

A family of G-protein-coupled receptors that bind to specific LYSOPHOSPHOLIPIDS such as lysophosphatidic acid and lysosphinglipids such as sphingosine-1-phosphate. They play an important role in the formation and function of the CARDIOVASCULAR SYSTEM.


Insurance Audit
Insurance Claims Analysis
Claims Review
Claim Review, Insurance
Analysis, Claims
Insurance Claims Processing
Review, Claims
Review, Insurance Claim
Claims Analysis
Insurance Claim Review

Review of claims by insurance companies to determine liability and amount of payment for various services. The review may also include determination of eligibility of the claimant or beneficiary or of the provider of the benefit; determination that the benefit is covered or not payable under another policy; or determination that the service was necessary and of reasonable cost and quality.


VIP (Vasoactive Intestinal Peptide)
Vasoactive Intestinal Polypeptide
Vasoactive Intestinal Peptide
Vasointestinal Peptide

A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).


Electrophoresis, Microchip
Microchip Electrophoresis

A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.


Sebaceous Gland Neoplasms
Neoplasms, Sebaceous Gland

New abnormal growth of tissue in the SEBACEOUS GLANDS.


A noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.


Immunity, Innate
Immunity, Natural
Innate Immune Response
Innate Immunity
Immunity, Non-Specific
Resistance, Natural
Immunity, Native

The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.


Esophageal Diverticulosis
Diverticulosis, Esophageal

A pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS.


A plant genus of the family HYDRANGEACEAE. Members contain hydrangenol, thunberginols, hydramacrosides A and B, and secoiridoid glucosides.


Brown Adipose Tissue
Adipose Tissue, Brown
Hibernating Gland
Brown Fat

A thermogenic form of adipose tissue composed of BROWN ADIPOCYTES. It is found in newborns of many species including humans, and in hibernating mammals. Brown fat is richly vascularized, innervated, and densely packed with MITOCHONDRIA which can generate heat directly from the stored lipids.


Mycobacterium Infections
Infections, Mycobacterium

Infections with bacteria of the genus MYCOBACTERIUM.


Inanimate objects that become enclosed in the eye.


Central Nervous System Depressants
CNS Depressants

A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).


An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89.


KCNA5 Potassium Channel
Kv1.5 Potassium Channel

A delayed rectifier subtype of shaker potassium channels that conducts a delayed rectifier current. It contributes to ACTION POTENTIAL repolarization of MYOCYTES in HEART ATRIA.


3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid

An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.


Heart-Lung Bypass
Cardiopulmonary Bypass
Bypass, Cardiopulmonary

Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.


Thymic Hyperplasia
Hyperplasia of Thymus Gland
Thymus Hyperplasia

Enlargement of the thymus. A condition described in the late 1940's and 1950's as pathological thymic hypertrophy was status thymolymphaticus and was treated with radiotherapy. Unnecessary removal of the thymus was also practiced. It later became apparent that the thymus undergoes normal physiological hypertrophy, reaching a maximum at puberty and involuting thereafter. The concept of status thymolymphaticus has been abandoned. Thymus hyperplasia is present in two thirds of all patients with myasthenia gravis. (From Segen, Dictionary of Modern Medicine, 1992; Cecil Textbook of Medicine, 19th ed, p1486)


Microtrauma, Physical
Micro Trauma, Physical

Small injuries caused by external force applied to the body including bones, muscles, nerves and tendons.


Therapies, Investigational
Experimental Therapies
Investigational Treatments
Investigational Therapies
Innovative Therapies

Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.


Blood-Air Barrier
Air-Blood Barrier
Alveolocapillary Membrane

The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.


Cancer Pain
Neoplasm-Related Pain
Cancer-Related Pain
Oncological Pain
Tumor-Related Pain
Tumor-Associated Pain
Cancer-Associated Pain
Oncology Pain
Neoplasm-Associated Pain

Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during NEOPLASM growth, tissue invasion, and METASTASIS.


A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.


Epilepsy
Seizure Disorder
Awakening Epilepsy
Epilepsy, Cryptogenic
Aura

A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)


Environmental Genomics
Population Genomics
Metagenomics
Community Genomics

The systematic study of the GENOMES of assemblages of organisms.


Essential oil extracted from MELALEUCA ALTERNIFOLIA (tea tree). It is used as a topical antimicrobial due to the presence of terpineol.


Viral Coat Proteins
Capsid Protein
Viral Outer Coat Protein
Coat Proteins
Capsid Proteins

Proteins that form the CAPSID of VIRUSES.


Characteristic events occurring in the ATMOSPHERE during the interactions and transformation of various atmospheric components and conditions.


Nevoxanthoendothelioma
Xanthogranuloma, Juvenile
Xanthoma, Juvenile

Benign disorder of infants and children caused by proliferation of HISTIOCYTES, macrophages found in tissues. These histiocytes, usually lipid-laden non-Langerhans cells, form multiple yellow-red nodules most often in the skin, the eye, and sometimes in the viscera. Patients appear to have normal lipid metabolism and are classified as a normolipemic non-Langerhans cell histiocytosis.


Drug Reaction Reporting Systems, Adverse

Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.


Computers in which quantities are represented by physical variables; problem parameters are translated into equivalent mechanical or electrical circuits as an analog for the physical phenomenon being investigated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Disorders, Blood Coagulation
Blood Coagulation Disorders
Coagulation Disorders, Blood

Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.


Perimeningeal Infections
Infections, Perimeningeal
Parameningeal Infections
Infections, Parameningeal

Infectious processes, including abscesses, effusions, and empyemas which occur in the epidural or subdural spaces surrounding the brain and spinal cord.


Biologic Assays
Biological Assay
Assay, Biological
Bioassay
Assays, Biological
Biologic Assay

A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.


National Institute on Alcohol Abuse and Alcoholism (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts research focused on improving the treatment and prevention of alcoholism and alcohol-related problems to reduce the health, social, and economic consequences of this disease. NIAAA, NIMH, and NIDA were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.


HbS Disease
Anemia, Sickle Cell
Sickle Cell Disorders
Hemoglobin S Disease
Sickle Cell Anemia
Sickle Cell Disease
Sickling Disorder Due to Hemoglobin S

A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.


Pituitary Adenylate Cyclase-Activating Peptide Receptors

Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide

A family of G-protein-coupled receptors that share significant homology with GLUCAGON RECEPTORS. They bind PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE with high affinity and trigger intracellular changes that influence the behavior of CELLS.


Medicare+Choice Program (US)
Medicare Advantage
Medicare Plus Choice
Medicare Part C
Medicare Plus Choice Program (US)
Medicare Choice

The Balanced Budget Act (BBA) of 1997 establishes a Medicare+Choice program under part C of Title XVIII, Section 4001, of the Social Security Act. Under this program, an eligible individual may elect to receive Medicare benefits through enrollment in a Medicare+Choice plan. Beneficiaries may choose to use private pay options, establish medical savings accounts, use managed care plans, or join provider-sponsored plans.


Facet Joint
Zygapophyseal Joint
Zygapophysial Joint

The joint that occurs between facets of the interior and superior articular processes of adjacent VERTEBRAE.


Drug Monitoring
Monitoring, Drug
Therapeutic Drug Monitoring

The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.


Sphaerophorus necrophorus
Fusobacterium necrophorum

A species of gram-negative, non-spore-forming bacteria isolated from the natural cavities of man and other animals and from necrotic lesions, abscesses, and blood.


Colistin
Colistin Sulfate
Colisticin
Colimycin
Polymyxin E
Totazina
Coly-Mycin

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.


AGRP Protein
Agouti-Related Protein
AGRT Protein

A secreted protein of approximately 131 amino acids that is related to AGOUTI SIGNALING PROTEIN and is also an antagonist of MELANOCORTIN RECEPTOR activity. It is expressed primarily in the HYPOTHALAMUS and the ADRENAL GLAND. As a paracrine signaling molecule, AGRP is known to regulate food intake and body weight. Elevated AGRP has been associated with OBESITY.


Dendritic Epithelial T Cells
Gamma Delta T Lymphocytes
Mucosal T Lymphocytes
Gamma Delta T Cells
Intraepithelial Lymphocytes
Intraepithelial T Lymphocytes
Intraepithelial T Cells
Mucosal T Cells

T Lymphocytes with limited diversity of receptors (e.g., ALPHA E INTEGRINS) in the epidermis of the skin and the mucosal linings. They recognize common microbes via T-CELL RECEPTORS and PATHOGEN-ASSOCIATED MOLECULAR PATTERN MOLECULES and function as effector cells for INNATE IMMUNITY. Activation of intraepithelial lymphocytes is a marker for various gastrointestinal diseases (e.g., CELIAC DISEASE; HAIRY CELL LEUKEMIA; and ENTEROPATHY-ASSOCIATED T-CELL LYMPHOMA).


A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.


Department of Agriculture (U.S.)
United States Department of Agriculture
USDA
United States. Dept. of Agriculture

A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.


Fast-Wave Sleep
REM Sleep
Rapid Eye Movements
Sleep, Fast-Wave
Sleep, REM
Paradoxical Sleep
Rhombencephalic Sleep

A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.


Abdominal Pregnancy
Pregnancy, Abdominal

A type of ectopic pregnancy in which the EMBRYO, MAMMALIAN implants in the ABDOMINAL CAVITY instead of in the ENDOMETRIUM of the UTERUS.


Datura stramonium
Jimson Weed
Jimsonweed
Thornapple
Stramonium

A plant species of the genus DATURA, family SOLANACEAE, that contains TROPANES and other SOLANACEOUS ALKALOIDS.


Succinate Dehydrogenase-Coenzyme Q Reductase

A flavoprotein oxidase complex that contains iron-sulfur centers. It catalyzes the oxidation of SUCCINATE to fumarate and couples the reaction to the reduction of UBIQUINONE to ubiquinol.


Ear, Inner
Inner Ear
Membranous Labyrinth
Ear, Internal
Bony Labyrinth
Labyrinth

The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.


Voltage-Gated Sodium Channel beta-2 Subunit

A voltage-gated sodium channel beta subunit that binds covalently to voltage-gated alpha subunits.


Diphosphates
Pyrophosphate Analogs
Pyrophosphates

Inorganic salts of phosphoric acid that contain two phosphate groups.


Arginine-Specific tRNA
RNA, Transfer, Arg
tRNA(Arg)
tRNAArg
Transfer RNA, Arg

A transfer RNA which is specific for carrying arginine to sites on the ribosomes in preparation for protein synthesis.


Bay-Region, Polycyclic Aromatic Hydrocarbon

Polycyclic Aromatic Hydrocarbon Bay-Region

A concave exterior region on some POLYCYCLIC AROMATIC HYDROCARBONS that have three phenyl rings in a non-linear arrangement.


A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.


A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.


Transcription Factor GATA-2
Nuclear Factor-Erythroid 1B
NFE1B Erythroid Transcription Factor
GATA-Binding Protein 2
GATA2 Transcription Factor

An essential GATA transcription factor that is expressed primarily in HEMATOPOIETIC STEM CELLS.


Hydatid Cyst, Hepatic
Alveolar Echinococcis, Hepatic
Echinococcosis, Hepatic Alveolar
Echinococcosis, Hepatic
Hydatidosis, Hepatic

Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST).


Mycobacterium buruli
Mycobacterium ulcerans

A slow-growing mycobacterium that infects the skin and subcutaneous tissues, giving rise to indolent BURULI ULCER.


Mycobacterium avium subsp. paratuberculosis

Mycobacterium avium subspecies paratuberculosis

A subspecies of gram-positive, aerobic bacteria. It is the etiologic agent of Johne's disease (PARATUBERCULOSIS), a chronic GASTROENTERITIS in RUMINANTS.


The process by which the V (variable), D (diversity), and J (joining) segments of IMMUNOGLOBULIN GENES or T-CELL RECEPTOR GENES are assembled during the development of LYMPHOID CELLS using NONHOMOLOGOUS DNA END-JOINING.


Tetralogy, Fallot's
Tetralogy of Fallot
Fallot's Tetralogy

A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.


Romotal
9-Amino-1,2,3,4-Tetrahydroacridine
Tetrahydroaminoacridine
1,2,3,4-Tetrahydroaminoacridine
1,2,3,4-Tetrahydro-9-acridinamine
Tenakrin
THA
Tacrine
Cognex
Tacrine Hydrochloride

A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.


A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).


Presentation, Fetal
Fetal Malpresentation
Labor Presentation
Fetal Presentation

The position or orientation of the FETUS at near term or during OBSTETRIC LABOR, determined by its relation to the SPINE of the mother and the birth canal. The normal position is a vertical, cephalic presentation with the fetal vertex flexed on the NECK.


Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.


Fatty Acid Acyl-CoA Oxidase
Acyl Coenzyme A Oxidase
Fatty Acyl-Coenzyme A Oxidase
Acyl-CoA Oxidase
Fatty Acyl-CoA Oxidase

An enzyme that catalyzes the first and rate-determining steps of peroxisomal beta-oxidation of fatty acids. It acts on COENZYME A derivatives of fatty acids with chain lengths from 8 to 18, using FLAVIN-ADENINE DINUCLEOTIDE as a cofactor.


An enzyme of the transferase class that catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate in the PENTOSE PHOSPHATE PATHWAY. (Dorland, 27th ed) EC 2.2.1.1.


Lacrimal Sac
Nasolacrimal Duct
Tear Duct

A tubular duct that conveys TEARS from the LACRIMAL GLAND to the nose.


A usually spherical cyst, arising as an embryonic out-pouching of the foregut or trachea. It is generally found in the mediastinum or lung and is usually asymptomatic unless it becomes infected.


Book Plates as Topic
Bookplates as Topic

Works about labels pasted in books to mark their ownership and sometimes to indicate their location in a library.


Fur Seals
Callorhinus
Arctocephalus
Seals, Eared

A genus of fur seals in the family Otariidae, which includes the South American, New Zealand, and Galapagos fur seals among other species.


Ara-U
Uracil Arabinoside
Uracil Arabinofuranoside
Arabinosyluracil
Sponguridine
NSC 68928
Arauridine
Arabinofuranosyluracil
1-beta-D-Arabinofuranosyl Uracil

A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.


Phytotherapy
Herb Therapy
Herbal Therapy

Use of plants or herbs to treat diseases or to alleviate pain.


Abscess, Psoas
Pyogenic Iliopsoas Abscess
Iliopsoas Abscess
Psoas Abscess

Abscess of the PSOAS MUSCLES resulting usually from disease of the lumbar vertebrae, with the pus descending into the muscle sheath. The infection is most commonly tuberculous or staphylococcal.


Immunological Memory
Memory, Immunologic
Immunologic Memory

The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.


Dermatophagoides pteronyssinus
European House Dust Mite
House Dust Mite, European

Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.


HUVEC Cells
Human Umbilical Vein Endothelial Cells
Endothelial Cells, Human Umbilical Vein

Endothelial cells that line venous vessels of the UMBILICAL CORD.


Haem
Protoheme
Ferroprotoporphyrin
Heme
Protoheme IX
Heme b

The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.


Adipophilin
PLIN2 Protein
ADRP Protein
Adipose Differentiation-Related Protein
Perilipin-2
Perilipin 2 Protein

A perilipin that is expressed by many different cell types. It binds FATTY ACIDS and CHOLESTEROL,  stabilizes TRIGLYCERIDES, and localizes to both the surface and hydrophobic core of LIPID DROPLETS, as well as the ENDOPLASMIC RECTICULUM and PLASMA MEMBRANE in MACROPHAGES. It also plays a central role in the biogenesis of lipid droplets and FOAM CELLS and is highly expressed by macrophages at atherosclerotic lesions in human arteries along with the INFLAMMATION markers TNF-ALPHA; MCP-1 RECEPTOR; and IL-6.


H4 Receptors
Histamine H4 Receptor
Histamine H4 Receptors
Receptors, Histamine H4

G-Protein-coupled histamine receptors that are expressed primarily in BONE MARROW as well as in peripheral tissues and organs. They are expressed by immune cells that include EOSINOPHILS; T-CELLS; DENDRITIC CELLS; and MAST CELLS.


Fenestra or oval opening on the lateral wall of the vestibular labyrinth adjacent to the MIDDLE EAR. It is located above the cochlear round window and normally covered by the base of the STAPES.


ATP Binding Cassette Transporter, Sub-Family D, Member 1

ATP Binding Cassette Transporter, Subfamily D, Member 1

ATP-binding cassette transporter that functions in the import of long chain (13-21 carbons) and very long chain fatty acids (> 22 carbons), or their acyl-CoA-derivatives, into PEROXISOMES. Mutations in the ABCD1 gene are associated with the X-linked form of ADRENOLEUKODYSTROPHY.


Biometric Identification
Biometric Authentication
Automated Facial Recognition

Electronic identification of a human based on attributes of the face.


A congenital anomaly of the hand or foot, marked by the webbing between adjacent fingers or toes. Syndactylies are classified as complete or incomplete by the degree of joining. Syndactylies can also be simple or complex. Simple syndactyly indicates joining of only skin or soft tissue; complex syndactyly marks joining of bony elements.


Glafenin Exidol Glafenine Glaphenine Glycerylaminophenaquine

An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.


Environment, Health Facility
Family Planning, Environment
Health Facility Environment

Physical surroundings or conditions of a hospital or other health facility and influence of these factors on patients and staff.


The illumination of an environment and the arrangement of lights to achieve an effect or optimal visibility. Its application is in domestic or in public settings and in medical and non-medical environments.


Interferon, gamma
Interferon-gamma
Interferon Type II
Type II Interferon
gamma-Interferon
Interferon, Immune

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.


Daytime Wetting
Daytime Urinary Incontinence
Diurnal Enuresis

Involuntary discharge of URINE during the daytime while one is awake.


Salmonella Vaccines
Salmonellosis Vaccines
Vaccines, Salmonella

Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.


Design, Environment
Healthy Places
Environment Design

The structuring of the environment to permit or promote specific patterns of behavior.


Adenosylmethionine Decarboxylase
S-Adenosylmethionine Decarboxylase

An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-aminopropyl-(1), methylsulfonium salt. It is one of the enzymes responsible for the synthesis of spermidine from putrescine. EC 4.1.1.50.


Antibiotics, Penicillin
Penicillins
Penicillin

A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)


Schwannoma-derived Growth Factor
Amphiregulin

An autocrine growth factor and mitogen for a broad range of target cells including EPITHELIAL CELLS; FIBROBLASTS and immune cells. It occurs as a membrane-bound protein that can be cleaved to release an active secreted form.


Intestinal infection with organisms of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.


Gravity Sensing
Gravity Perception
Gravisensing

Process whereby a cell, bodily structure, or organism (animal or plant) receives or detects a gravity stimulus. Gravity sensing plays an important role in the directional growth and development of an organism (GRAVITROPISM).


Phylum in the domain Eukarya, comprised of animals either with fully developed backbones (VERTEBRATES), or those with notochords only during some developmental stage (CHORDATA, NONVERTEBRATE).


Antigen Receptor
Antigen Receptors
Receptors, Antigen

Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.


Reproductive and Urinary Tract Physiology

Reproductive and Urinary Physiology Concepts

Reproductive and Urinary Tract Physiological Phenomena

Reproductive and Urinary Physiology Phenomenon

Reproductive and Urinary Tract Physiological Phenomenon

Reproductive and Urinary Tract Physiological Concepts

Reproductive and Urinary Physiological Phenomenon

Reproductive and Urinary Physiology Phenomena

Reproductive and Urinary Physiological Phenomena

Physiology of the human and animal body, male or female, in the processes and characteristics of REPRODUCTION and the URINARY TRACT.


Trichloropropene Oxide
Trichloroepoxypropane
1,2-Epoxy-3,3,3-Trichloropropane
Trichloropropane Oxide
Trichloropropylene Oxide
1,1,1-Trichloropropene-2,3-oxide

A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.


Feeding and Eating Disorders of Childhood

Mental disorders related to feeding and eating usually diagnosed in infancy or early childhood.


A plant genus of the family STERCULIACEAE. S. urens is the source of KARAYA GUM which is sometimes called Indian tragacanth, which is different from the true TRAGACANTH which comes from ASTRAGALUS GUMMIFER.


Infusions, Subcutaneous
Subcutaneous Infusions

The administration of liquid medication or nutrients under the skin, usually over minutes or hours.


A species of cobra (Naja) that is indigenous primarily to Northern Africa.


Brain Damage, Chronic
Encephalopathy, Chronic
Chronic Encephalopathy

A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.


Orthodontic Braces
Orthodontic Brackets
Dental Braces

Small metal or ceramic attachments used to fasten an arch wire. These attachments are soldered or welded to an orthodontic band or cemented directly onto the teeth. Bowles brackets, edgewise brackets, multiphase brackets, ribbon arch brackets, twin-wire brackets, and universal brackets are all types of orthodontic brackets.


A group of physiologically active prostaglandin endoperoxides. They are precursors in the biosynthesis of prostaglandins and thromboxanes. Most frequently encountered member of this group is the prostaglandin G2.


Desacetyllanatoside C
Deslanoside
Cedilanid-D
Deslanatoside C
Desacetyldigilanide C
Desacetyl Lanatoside

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.


Caspase and Rip Adaptor with Death Domain Protein

RIP-Associated Protein With a Death Domain

A death domain receptor signaling adaptor protein that plays a role in signaling the activation of INITIATOR CASPASES such as CASPASE 2. It contains a death domain that is specific for RIP SERINE-THEONINE KINASES and a caspase-binding domain that binds to and activates CASPASES such as CASPASE 2.


Materials that add an electron to an element or compound, that is, decrease the positiveness of its valence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)


Polychlorobiphenyl Compounds
PCBs
Polychlorinated Biphenyls

Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.


Trout, Rainbow
Oncorhynchus mykiss
Trout, Redband
Salmo gairdneri
Steelhead

A large stout-bodied, sometimes anadromous, TROUT found in still and flowing waters of the Pacific coast from southern California to Alaska. It has a greenish back, a whitish belly, and pink, red, or lavender stripes on the sides, with usually a sprinkling of black dots. It is highly regarded as a sport and food fish. Its former name was Salmo gairdneri. The sea-run rainbow trouts are often called steelheads. Redband trouts refer to interior populations of rainbows.


Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.


A glycoprotein albumin from hen's egg white with strong iron-binding affinity.


C elegans Proteins
Caenorhabditis elegans Proteins

Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.


A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.


A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).


Hepatitis Virus, Canine
Canine Adenovirus
Canine Adenoviruses
Canine Infectious Hepatitis Virus
Infectious Canine Hepatitis Virus
Hepatitis Virus, Infectious Canine
Adenoviruses, Canine

Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.


Antiviral Agents
Antivirals
Antiviral Drugs

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.


Myoglobin which is in the oxidized ferric or hemin form. The oxidation causes a change in color from red to brown.


Ovulation Suppression
Ovulation Inhibition

Blocking the process leading to OVULATION. Various factors are known to inhibit ovulation, such as neuroendocrine, psychological, and pharmacological agents.


Marginal Ulcer
Peptic Ulcer
Gastroduodenal Ulcer

A well-known complication of GASTROENTEROSTOMY. These ulcers occur at the gastrojejunal anastomosis, mostly on the jejunal side.


Plakins
Cytoskeletal Linker Proteins
Cytolinker Proteins
Cytoskeletal Adaptor Proteins

A family of related proteins that associate with cytoskeletal elements and junctional complexes at INTERCELLULAR JUNCTIONS. Plakins share a common plakin domain or a plakin repeat domain.


Athymic Rats
Nude Rats
Rats, Athymic
Rats, Nude

A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.


Keratosis Palmoplantaris with Periodontopathia

Rare, autosomal recessive disorder occurring between the first and fifth years of life. It is characterized by palmoplantar keratoderma with periodontitis followed by the premature shedding of both deciduous and permanent teeth. Mutations in the gene for CATHEPSIN C have been associated with this disease.


Chemical Fractionation
Fractionation, Chemical

Separation of a mixture in successive stages, each stage removing from the mixture some proportion of one of the substances, for example by differential solubility in water-solvent mixtures. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


A genus of trematode flukes belonging to the family Schistosomatidae. There are over a dozen species. These parasites are found in man and other mammals. Snails are the intermediate hosts.


Receptors, AMPA
AMPA Receptor
AMPA Receptors
Quisqualate Receptors
Quisqualate Receptor

A class of ionotropic glutamate receptors characterized by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid).


Interleukin-8A Receptors
IL-8A Receptor
NAP-1 Receptor
Receptors, CXCR1
Interleukin 8A Receptor
Interleukin 8 Receptor Type A
CXCR1 Receptor
High Affinity Interleukin-8 Receptor A
CXC Chemokine Receptor 1
MDNCF Receptors
Antigens, CDw128a
Receptors, Interleukin-8A
CXCR1 Receptors
IL-8A Receptors
CDw128a Antigens

High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and BASOPHILS.


Leakage, Dental
Dental Leakages
Leakages, Dental
Dental Leakage

The seepage of fluids, debris, and micro-organisms between the walls of a prepared dental cavity and the restoration.


Papulosquamous Disorders
Papulosquamous Skin Diseases
Skin Diseases, Papulosquamous

A group of dermatoses with distinct morphologic features. The primary lesion is most commonly a papule, usually erythematous, with a variable degree of scaling on the surface. Plaques form through the coalescing of primary lesions.


Narcotic Bowel Syndrome
Opioid-Induced Constipation
Opiate-Induced Constipation

CONSTIPATION associated with the use of OPIOIDS.


Heat stroke caused by exposure to the sun. It is characterized by dangerously high BODY TEMPERATURE; red, hot skin; DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.


An organized procedure carried out through committees to review admissions, duration of stay, professional services furnished, and to evaluate the medical necessity of those services and promote their most efficient use.


Specialty Uses of Chemicals
Specialty Chemicals and Products

Uses of chemicals in a research, industrial, or household setting. This does not include PHARMACOLOGIC ACTIONS.


Kala-Azar
Leishmaniasis, Visceral
Black Fever

A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.


A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.


Epidermal Cells
Epidermal Cell
Epidermic Cells

Cells from the outermost, non-vascular layer (EPIDERMIS) of the skin.


Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.


Electrophoresis, Agar Gel
Electrophoresis, Agarose Gel

Electrophoresis in which agar or agarose gel is used as the diffusion medium.


Testis-Blood Barrier
Blood-Testis Barrier

A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.


lambda-Immunoglobulin Light Chains
lambda-x Immunoglobulin
lambda-Chain Immunoglobulins
lambda-1-Immunoglobulin
Immunoglobulin lambda-Chains
Ig lambda Chains
Immunoglobulin lambda-Chain
lambda-Immunoglobulin Light Chain
Immunoglobulins, lambda-Chain
lambda-2-Immunoglobulin

One of the types of light chain subunits of the immunoglobulins with a molecular weight of approximately 22 kDa.


Laser Scanning Cytometry
Cytometry, Laser Scanning

A scanning microscope-based, cytofluorimetry technique for making fluorescence measurements and topographic analysis on individual cells. Lasers are used to excite fluorochromes in labeled cellular specimens. Fluorescence is detected in multiple discrete wavelengths and the locational data is processed to quantitatively assess APOPTOSIS; PLOIDIES; cell proliferation; GENE EXPRESSION; PROTEIN TRANSPORT; and other cellular processes.


Female Genital Neoplasms
Genital Neoplasms, Female
Neoplasms, Gynecologic
Neoplasms, Female Genital
Gynecologic Neoplasms

Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).


Tumor Necrosis Factor Receptor Superfamily, Member EDAR

A ectodysplasin receptor subtype that is specific for ECTODYSPLASIN A1. It signals via the specific signaling adaptor EDAR-ASSOCIATED DEATH DOMAIN PROTEIN. Loss of function of the edar receptor is associated with AUTOSOMAL RECESSIVE ANHIDROTIC ECTODERMAL DYSPLASIA and ECTODERMAL DYSPLASIA 3, ANHIDROTIC.


Adrenergic beta-3 Receptor Agonists
Adrenergic beta3-Agonists
Adrenergic beta-3 Receptor Agonist
Adrenergic beta-3 Agonists

Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS.


Sugar Alcohol Dehydrogenases
Sugar Alcohol Oxidoreductases

Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.


Active involvement in the political process including promoting, impeding or raising awareness of a certain issue or set of issues.


Umbilical Cord Blood Stem Cell Transplantation

Placental Blood Stem Cell Transplantation

Blood Stem Cell Transplantation, Umbilical Cord

Stem Cell Transplantation, Placental Blood

Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.


A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.


Asbestos, Amphibole
Amphiboles
Asbestos, Amphibole-group Minerals
Amphibole Asbestos

A class of asbestos that includes silicates of magnesium, iron, calcium, and sodium. The fibers are generally brittle and cannot be spun, but are more resistant to chemicals and heat than ASBESTOS, SERPENTINE. (From Hawley's Condensed Chemical Dictionary, 11th ed)


Human Coronavirus OC43
HCoV-OC43
Coronavirus OC43, Human

A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.


National Institute for Occupational Safety and Health, U.S.

United States National Institute for Occupational Safety and Health

National Institute for Occupational Safety and Health (U.S.)

An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.


Environmental Health Science
Environmental Health
Health, Environmental

The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health.


7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.


A degradation product of ethylenebis(dithiocarbamate) fungicides. It has been found to be carcinogenic and to cause THYROID hyperplasia.


Viral Infections, Central Nervous System

Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.


International Federation of Red Cross and Red Crescent Societies

International Red Cross and Red Crescent Movement

International Committee of the Red Cross

International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.


Experience-based techniques for problem-solving, learning, and discovery that find a solution which is not guaranteed to be optimal, but sufficient for a given set of goals.


Silver Pefloxacin
Pefloxacin Mesylate Dihydrate
Pefloxacine
Peflacine
2589 R.B.
Pefloxacin Mesylate
Abactal
Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.


HLH Motifs
Helix-Loop-Helix Domain
Motifs, Helix-Loop-Helix
Helix-Loop-Helix Domains
Helix-Loop-Helix Motif
Helix-Loop-Helix Motifs

Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.


Optic Nerve
Second Cranial Nerve
Nervus Opticus
Cranial Nerve II

The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.


The process by which chemical compounds provide protection to cells against harmful agents.


A plant genus of the family SCROPHULARIACEAE. Members contain iridoids.


Procollagen-Proline Dioxygenase
Protocollagen Prolyl Hydroxylase
Procollagen Prolyl 4-Hydroxylase

A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.


Periodontal Cyst, Apical
Radicular Cyst
Periapical Cyst

Slow-growing fluid-filled epithelial sac at the apex of a tooth with a nonvital pulp or defective root canal filling.


Fulminating Liver Failure
Liver Failure, Fulminant
Acute Hepatic Failure
Fulminant Hepatic Failure
Hepatic Failure, Acute
Liver Failure, Acute
Hepatic Failure, Fulminant
Acute Liver Failure
Fulminating Hepatic Failure

A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.


Virtual Systems
Interface, User Computer
User Computer Interface
User-Computer Interface

The portion of an interactive computer program that issues messages to and receives commands from a user.


Neurogenic Locus Notch Homolog Protein 3

A notch receptor characterized by a large extracellular domain containing 34 EPIDERMAL GROWTH FACTOR-like repeats. It functions to regulate CELL DIFFERENTIATION; APOPTOSIS; and CELL PROLIFERATION. Mutations in the EGF repeats of Notch-3 are associated with CADASIL.


Litigation
Medical Jurisprudence
Constitutional Law
Legal Obligations
Law
Legal Aspects
Jurisprudence
Legal Status
Court Decision
State Interest

The science or philosophy of law. Also, the application of the principles of law and justice to health and medicine.


Ethoxyresorufin O-Deethylase
Ethoxyresorufin Dealkylase
CYP 1A1
Cytochrome P-450 CYP1A1
EROD
Ethylresorufin O-Deethylase
Cytochrome P450 IA1
7-Ethoxyresorufin O-Deethylase
CYP1A1
CYP1A1 Protein

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.


Tumor Necrosis Factor Receptor Superfamily, Member 9

A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Hepatitis Antibodies
Antibodies, Hepatitis

Immunoglobulins raised by any form of viral hepatitis; some of these antibodies are used to diagnose the specific kind of hepatitis.


Eczema Herpeticum
Kaposi's Varicelliform Eruption
Kaposi Varicelliform Eruption
Eczema Vaccinatum

A disseminated vesicular-pustular eruption caused by the herpes simplex virus (HERPESVIRUS HOMINIS), the VACCINIA VIRUS, or Varicella zoster (HERPESVIRUS 3, HUMAN). It is usually superimposed on a preexisting, inactive or active, atopic dermatitis (DERMATITIS, ATOPIC).


Tryptophan Synthase
Tryptophan Synthetase

An enzyme that catalyzes the conversion of L-serine and 1-(indol-3-yl)glycerol 3-phosphate to L-tryptophan and glyceraldehyde 3-phosphate. It is a pyridoxal phosphate protein that also catalyzes the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. (From Enzyme Nomenclature, 1992) EC 4.2.1.20.


Dihydrothymine Dehydrogenase (NADP)
Dihydrouracil Dehydrogenase (NADP)
Dihydropyrimidine Dehydrogenase

An oxidoreductase involved in pyrimidine base degradation. It catalyzes the catabolism of THYMINE; URACIL and the chemotherapeutic drug, 5-FLUOROURACIL.


Recoverin
S-Modulin
Sensitivity-Modulating Protein
Cancer-Associated Retinopathy Antigen

A neuronal calcium-sensor protein that is found in ROD PHOTORECEPTORS and CONE PHOTORECEPTORS. It interacts with G-PROTEIN-COUPLED RECEPTOR KINASE 1 in a Ca2+ dependent manner and plays an important role in PHOTOTRANSDUCTION.


Paget Disease of Bone
Osteitis Deformans
Paget's Disease of Bone
Osseous Paget's Disease
Paget Disease, Bone

A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.


Vanilloid Receptors
TRPV Cation Channels
Capsaicin Receptors

A subgroup of TRP cation channels named after the vanilloid receptor. They are very sensitive to TEMPERATURE; hot spicy food, and CAPSAICIN. They contain a TRP domain (a five-turn amphipathic helix with an invariant TRYPTOPHAN) and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.


Coccus-shaped bacteria that retain the crystal violet stain when treated by Gram's method.


S3-12 Protein
Plin4 Protein
Perilipin-4
Perilipin 4 Protein

A perilipin protein characterized by an extensive 11-mer repeat region, which forms five adjacent alpha-helices. It is expressed primarily in WHITE ADIPOSE TISSUE and differentiating ADIPOCYTES, as well as skeletal muscle and heart.  It is soluble in the cytoplasm but re-localizes to the surface of LIPID DROPLETS under high lipid conditions.


Nasal Surgery
Rhinosurgery
Nasal Surgical Procedures
Intranasal Surgery

Surgical operations on the nose and nasal cavity.


A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.


Nerve Tissue Protein S 100, beta Subunit

S-100 Calcium-Binding Protein beta Subunit

S100 Calcium Binding Protein beta Subunit

A calcium-binding protein that is 92 AA long, contains 2 EF-hand domains, and is concentrated mainly in GLIAL CELLS. Elevation of S100B levels in brain tissue correlates with a role in neurological disorders.


NatD N-Terminal Acetyltransferase
N-Terminal Acetyltransferase Type D
N-Terminal Acetyltransferase D

An N-terminal acetyltransferase subtype that consists of the Naa40p catalytic subunit. It has specificity for N-termini of HISTONE H2A and HISTONE H4.


Hypotension, Orthostatic
Hypotension, Postural
Orthostatic Hypotension

A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.


A species in the genus PHLEBOVIRUS of the family BUNYAVIRIDAE, infecting vertebrates and vectored by ticks. It has not been associated with human disease though antibodies have been isolated from human sera.


Sodium-Phosphate Cotransporter Proteins, Type I

Sodium-Phosphate Symporter Proteins, Type I

Type I Na-Dependent Phosphate Cotransporter

Type I Sodium-Phosphate Cotransporter Proteins

A family of sodium-phosphate cotransporter proteins that also transport organic ANIONS. They are low affinity phosphate transporters.


THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).


Gene Rearrangement, T-Cell Antigen Receptor

Ordered rearrangement of T-cell variable gene regions coding for the antigen receptors.