Batrachotoxin is the 20-alpha-bromobenzoate of batrachotoxin A; they are toxins from the venom of a small Colombian frog, Phyllobates aurotaenia, cause release of acetylcholine, destruction of synaptic vesicles and depolarization of nerve and muscle fibers.


Biogenic Amines
Biogenic Amine
Amines, Biogenic

A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.


12-Carbon saturated monocarboxylic acids.


Acid Phosphate Fluoride
Acidulated Phosphate Fluoride
Phosphate Fluoride, Acidulated

A sodium fluoride solution, paste or powder, which has been acidulated to pH 3 to 4 and buffered with a phosphate. It is used in the prevention of dental caries.


Neoplasms, Nervous System
Nervous System Neoplasms
Tumors of the Nervous System
Nervous System Tumors

Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.


Neutrophil Glycoprotein Gp150
Receptor, CR4
Leukocyte Adhesion Protein p150,95
Integrin alphaXbeta2
Complement Receptor Type 4
Complement Receptor 4
p150,95 Glycoprotein
p150,95 Antigen
alphaXbeta2 Integrin
Antigen p150,95
Neutrophil GP150
CR4 Receptor

A major adhesion-associated heterodimer molecule expressed by MONOCYTES; GRANULOCYTES; NK CELLS; and some LYMPHOCYTES. The alpha subunit is the CD11C ANTIGEN, a surface antigen expressed on some myeloid cells. The beta subunit is the CD18 ANTIGEN.


POU Domain, Class 4, Transcription Factor 3

A POU domain factor that activates neuronal cell GENETIC TRANSCRIPTION of GENES encoding NEUROFILAMENT PROTEINS, alpha internexin, and SYNAPTOSOMAL-ASSOCIATED PROTEIN 25. Mutations in the Brn-3c gene have been associated with DEAFNESS.


Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.


A type I keratin that is found associated with the KERATIN-3 in the CORNEA and is regarded as a marker for corneal-type epithelial differentiation. Mutations in the gene for keratin-12 have been associated with MEESMANN CORNEAL EPITHELIAL DYSTROPHY.


A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.


Receptors, Kisspeptin-1
KISS1R
KISS1 Receptor
G Protein-Coupled Receptor 54
Kisspeptin-1 Receptor

G protein coupled receptors for the C-terminally amidated peptide of KISSPEPTIN-1. KISS1R plays an essential role in sexual development during puberty through its regulation of GONADOTROPIN-released hormones.


Lung Water, Extra Vascular
Extra Vascular Lung Water
Extravascular Lung Water
Lung Water, Extravascular

Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.


Dicyclomine
Di-Spaz
Merbentyl
Spascol
Dibent
Dicyclomine Hydrochloride
Lomine
Bentyl
Diclomin
Bentylol
OR-Tyl
Di-Cyclonex
Dicycloverin

A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.


Minichromosome Maintenance Complex Component 5

A minichromosome maintenance protein that is a key component of the six member MCM protein complex. In addition, interaction of this protein with cyclin A results in its recruitment to CENTROSOMES where it may play a role in controlling centrosome reduplication.


Proto-Oncogene Proteins c-bcr
bcr Proto-Oncogene Proteins
Proto-Oncogene Protein c-bcr
c-bcr Proto-Oncogene Proteins
Proto-Oncogene Protein bcr
c-bcr Proteins
Breakpoint Cluster Region Protein

A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.


Creatine Kinase, BB Form
Brain Creatine Kinase
BB Creatine Kinase

A form of creatine kinase found in the BRAIN.


Nursing, Obstetric
Obstetrical Nursing
Nursing, Obstetrical
Obstetric Nursing

A nursing specialty involving nursing care given to the pregnant patient before, after, or during childbirth.


Serine-tRNA Ligase
Seryl-tRNA Synthetase
Ser-tRNA Ligase
Seryl T RNA Synthetase

An enzyme that activates serine with its specific transfer RNA. EC 6.1.1.11.


Right Ventricular Function
Ventricular Function, Right

The hemodynamic and electrophysiological action of the right HEART VENTRICLE.


The smooth muscle coat of the uterus, which forms the main mass of the organ.


Sequence Tagged Sites
Sequence-Tagged Sites

Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.


Interleukin-23 Subunit p19
IL-23 p19
IL-23p19
Interleukin-23 alpha Subunit

A subunit of interleukin-23. It combines with INTERLEUKIN-12 SUBUNIT P40, which is shared between the two cytokines, to form in the active interleukin-23 cytokine.


A primary peripheral T-cell lymphoma in the gastrointestinal tract, most often in the jejunum, associated with a history of CELIAC DISEASE or other gastrointestinal diseases.


A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)


Technetium Tc 99m 2-Methoxy-2-methylpropylisonitrile

A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.


A pair of ducts near the WOLFFIAN DUCTS in a developing embryo. In the male embryo, they degenerate with the appearance of testicular ANTI-MULLERIAN HORMONE. In the absence of anti-mullerian hormone, mullerian ducts give rise to the female reproductive tract, including the OVIDUCTS; UTERUS; CERVIX; and VAGINA.


Tumor Necrosis Factor Receptor Superfamily, Member 6b

Receptors, Tumor Necrosis Factor, Member 6b

A secreted tumor necrosis factor receptor family member that has specificity FAS LIGAND and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14. It plays a modulating role in tumor necrosis factor signaling pathway.


Interleukin-13 Receptors
IL-13 Receptor
Receptors, Interleukin-13
Interleukin-13 Receptor
IL-13 Receptors
Receptor, Interleukin-13

Cell surface receptors for INTERLEUKIN-13. Included under this heading are the INTERLEUKIN-13 RECEPTOR ALPHA2 which is a monomeric receptor and the INTERLEUKIN-4 RECEPTOR TYPE II which has specificity for both INTERLEUKIN-4 and INTERLEUKIN-13.


Bacterial vaccines prepared from non-pathogenic, autologous bacteria of human origin. In Eastern Europe they are used in humans to treat chronic inflammatory disorders that are resistant to standard treatments. Worldwide they have veterinary use in all types of infectious disease.


Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.


Protein Methyltransferase III
Protein Lysine Methyltransferase
Protein Methylase III
Histone-Lysine Methyltransferase
Histone-Lysine N-Methyltransferase

An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine.


Pituitary TSH-Secreting Cells
Thyrotrophs
TSH Cells
Pituitary TSH-Producing Cells

Anterior pituitary cells that produce THYROID-STIMULATING HORMONE.


The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.


Brunner Glands
Brunner's Glands
Brunner Gland

The abundant submucosal mucous glands in the DUODENUM. These glands secrete BICARBONATE IONS; GLYCOPROTEINS; and PEPSINOGEN II.


Members of a religious community of men typically living under vows of poverty, chastity, and obedience.


Ethics Committees, Research
Research Ethics Committee
Review Board, Institutional
Research Ethics Committees
Board, Institutional Review
Review Boards, Institutional
Ethics Committee, Research
IRB
Institutional Review Board
IRBs
Institutional Review Boards
Boards, Institutional Review

Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.


Odds Ratio
Relative Odds
Risk Ratio
Cross-Product Ratio

The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.


Bluecomb of Turkeys
Transmissible Enteritis of Turkeys
Enteritis, Transmissible, of Turkeys

An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.


Health Insurance Exchanges
Health Insurance Marketplaces

State-provided health insurance marketplaces established under the PATIENT PROTECTION AND AFFORDABLE CARE ACT.


Switch Region, Immunoglobulin
Heavy-Chain Mu Switch Region
Ig Switch Region
Immunoglobulin Switch Region
Ig Switch Sequences

A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.


Anesthesia, Extradural
Epidural Anesthesia
Anesthesia, Peridural
Anesthesia, Epidural

Procedure in which an anesthetic is injected into the epidural space.


The study of the anatomical structures of animals.


Translation Initiation Factors, Prokaryotic

Peptide initiation factors from prokaryotic organisms. Only three factors are needed for translation initiation in prokaryotic organisms, which occurs by a far simpler process than in PEPTIDE CHAIN INITIATION, TRANSLATIONAL of eukaryotic organisms.


Holliday Junction Resolvases
Resolvases, Holliday Junction
Cruciform Cutting Endonuclease
Cruciform DNA Resolving Endonuclease
Holliday Junction Resolvase

Enzymes that recognize CRUCIFORM DNA structures and introduce paired incisions that help to resolve the structure into two DNA helices.


Autologous Antigens
Self-Antigens
Autoantigens

Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.


Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.


Copper Sulfate
Blue Vitriol
Cupric Sulfate

A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.


3,3'-Dimethoxybenzidine
Dianisidine
Dianisidine Sulfate
Dianisidine Dihydrochloride
Dianisidine Hydrochloride
O-Dianisidine

Highly toxic compound which can cause skin irritation and sensitization. It is used in manufacture of azo dyes.


A filarial parasite primarily of dogs but occurring also in foxes, wolves, and humans. The parasite is transmitted by mosquitoes.


Complement C5b
Complement 5b
C5b Complement
Complement Component 5b

The larger fragment generated from the cleavage of C5 by C5 CONVERTASE that yields COMPLEMENT C5A and C5b (beta chain + alpha' chain, the residual alpha chain, bound by disulfide bond). C5b remains bound to the membrane and initiates the spontaneous assembly of the late complement components to form C5b-8-poly-C9, the MEMBRANE ATTACK COMPLEX.


Cognitive Manifestations
Neurobehavioral Manifestations
Neurobehavioral Signs and Symptoms
Signs and Symptoms, Neurobehavioral
Cognitive Symptoms

Signs and symptoms of higher cortical dysfunction caused by organic conditions. These include certain behavioral alterations and impairments of skills involved in the acquisition, processing, and utilization of knowledge or information.


Hispanics
Cuban Americans
Latinas
Hispanic Americans
Latinos
Spanish Americans
Puerto Ricans

Persons living in the United States of Mexican (MEXICAN AMERICANS), Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans.


Clinic, Dental
Dental Clinic
Dental Clinics
Clinics, Dental

Facilities where dental care is provided to patients.


Poly dT
Thymine Polynucleotides
Poly T
Polydeoxythymidylate
Polythymidylic Acids

A group of thymine nucleotides in which the phosphate residues of each thymine nucleotide act as bridges in forming diester linkages between the deoxyribose moieties.


Oxygenated forms of carotenoids. They are usually derived from alpha and beta carotene.


Pharmacology, Clinical
Clinical Pharmacology

The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.


Large-Conductance Calcium-Activated Potassium Channels

A major class of calcium activated potassium channels whose members are voltage-dependent. MaxiK channels are activated by either membrane depolarization or an increase in intracellular Ca(2+). They are key regulators of calcium and electrical signaling in a variety of tissues.


A plant genus of the family ASTERACEAE. Steroidal activity has been observed in animals. Members of this genus contain sesquiterpene lactones such as tomentosin, OXEPINS such as zoapatanol, and kaurene type DITERPENES.


Adaptor Protein Complex Subunits
Clathrin Assembly Protein Subunits
Adaptor Protein Subunits

The subunits that make up the large, medium and small chains of adaptor proteins.


Artificial Sweeteners, Nutritive
Nutritive Sweeteners

Any agent that adds not only sweet taste but some energy value to food. They include natural sugars such as SUCROSE; FRUCTOSE; and GALACTOSE; and certain SUGAR ALCOHOLS.


A species of HENIPAVIRUS first identified in Australia in 1994 in HORSES and transmitted to humans. The natural host appears to be fruit bats (PTEROPUS).


Castleman's Disease
Castleman Disease
Angiofollicular Lymph Node Hyperplasia
Lymph Node Hyperplasia, Giant
Angiofollicular Lymphoid Hyperplasia
Castlemans Disease
Giant Lymph Node Hyperplasia
Castleman's Tumor
Angiofollicular Lymph Hyperplasia
Hyperplasia, Giant Lymph Node

Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.


Eryhem
Ferrous Hemoglobin
Hemoglobin
Hemoglobins

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.


Gonyaulax Toxin
Mitilotoxin
Saxitonin
Saxitoxin

A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.


d-Tubocurarine
Tubocurarine Chloride
Tubocurare
Tubocurarine
d-Tubocurare

A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.


Chemoembolization, Therapeutic
Therapeutic Chemoembolization

Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.


Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.


Sciatic Neuropathy
Sciatic Nerve Diseases
Sciatic Nerve Palsy
Neuralgia-Neuritis, Sciatic Nerve
Sciatic Neuritis
Lesion of Sciatic Nerve

Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)


Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.


Platelet-activating Factor Acetylhydrolase IB

A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.


Familial Hypercholesterolemia with Hyperlipemia

An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.


Pregnancy Trimesters
Trimesters, Pregnancy

The three approximately equal periods of a normal human PREGNANCY. Each trimester is about three months or 13 to 14 weeks in duration depending on the designation of the first day of gestation.


An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.


Brucella suis
Brucella melitensis biovar suis

A species of gram-negative bacteria, primarily infecting SWINE, but it can also infect humans, DOGS, and HARES.


Clofenvinfos Chlorphenvinphos Dermaton Chlorfenvinphos Birlane

An organophosphorus cholinesterase inhibitor that is used as an insecticide and an acaricide.


General or unspecified injuries to the soft tissue or bony portions of the face.


Erythrocyte Membrane Aspartic Proteinase

An aspartic endopeptidase that is similar in structure to CATHEPSIN D. It is found primarily in the cells of the immune system where it may play a role in processing of CELL SURFACE ANTIGENS.


Situational Awareness
Situation Awareness
Awareness

The act of "taking account" of an object or state of affairs. It does not imply assessment of, nor attention to the qualities or nature of the object.


SRY (Sex Determining Region Y)-Box Proteins

A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are organized in several subgroups according to structural identities found within the proteins.


A thick-rooted perennial (Cichorium intybus) native to Europe but widely grown for its young leaves used as salad greens and for its roots, dried and ground-roasted, used to flavor or adulterate coffee. (From Webster, 3d ed)


Small sets of evidence-based interventions for a defined patient population and care setting.


The interference of one perceptual stimulus with another causing a decrease or lessening in perceptual effectiveness.


Perycit
Niceritrol
Pentaerythritoltetranicotinate
Pentaerythritol Tetranicotinate
Niceritrol Tetrahydrochloride

An ester of nicotinic acid that lowers cholesterol and triglycerides in total plasma and in the VLD- and LD-lipoprotein fractions.


Unsaturated derivatives of the ESTRANES with methyl groups at carbon-13, with no carbon at carbon-10, and with no more than one carbon at carbon-17. They must contain one or more double bonds.


T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3

An Ig domain-containing membrane receptor that is expressed by TH1 CELLS. It regulates the activation of MACROPHAGES and inhibits TH1-mediated auto- and alloimmune responses to promote IMMUNE TOLERANCE.


Ethinyl Trichloride
Trielina
Trilene
Trichloroethene
Trichloroethylene

A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.


Orexin Receptor Antagonists
Orexin Receptor Blockers
Dual Orexin Receptor Antagonists

Substances that bind to and inhibit the action of OREXIN RECEPTORS. Drugs in this class have been used as SLEEP AIDS, PHARMACEUTICAL.


Proteins, Genetic Engineering
Protein Engineering
Genetic Engineering, Protein
Genetic Engineering of Proteins

Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.


Request for Proposal
Contract Bidding
Competitive Bidding

Pricing statements presented by more than one party for the purpose of securing a contract.


GTP Phosphohydrolase Activators
Small GTPase Activators
GTPase Activators

Agents and factors that activate GTP phosphohydrolase activity.


Prostaglandin delta-13-Reductase
delta 13-15-Ketoprostaglandin Reductase
15-Oxoprostaglandin 13-Reductase
delta-13-PG-Reductase
15-Ketoprostaglandin delta 13-Reductase
Prostaglandin-13,14-Reductase

(5Z)-(15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta(13)-oxidoreductase. An enzyme active in prostaglandin E and F catabolism. It catalyzes the reduction of the double bond at the 13-14 position of the 15-ketoprostaglandins and uses NADPH as cofactor. EC 1.3.1.48.


A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.


A genus of the subfamily CERCOPITHECINAE inhabiting the African forests. They are also known as mangabeys.


Pre-Existing Disorder
Pre-Existing Condition
Preexisting Illness
Preexisting Disease
Preexisting Disorder
Pre-Existing Illness
Preexisting Condition Coverage
Preexisting Condition
Pre-Existing Disease
Pre-Existing Condition Coverage

Insurance coverage of a physical or mental health condition, disability, or illness existing before health insurance is applied for or enrolled in.


The ability of a cell to change its PHENOTYPE in response to changes in the environment.


Kasabach-Merritt Phenomenon
Hemangioma Thrombocytopenia Syndrome
Thrombocytopenia-Hemangioma Syndrome
Kasabach-Merritt Syndrome
Hemangioma-Thrombocytopenia Syndrome

Rapidly growing vascular lesion along the midline axis of the neck, upper trunk, and extremities that is characterized by CONSUMPTION COAGULOPATHY; THROMBOCYTOPENIA; and HEMOLYTIC ANEMIA. It is often associated with infantile Kaposiform HEMANGIOENDOTHELIOMA and other vascular tumors such as tufted ANGIOMA.


Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.


Inflammatory Breast Cancer
Inflammatory Breast Carcinoma
Inflammatory Breast Cancer (IBC)
Inflammatory Breast Neoplasms

Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.


Selenium-Binding Proteins
Se-Binding Proteins

A group of proteins that covalently attach to selenium or SELENIUM-containing compounds.


Junctional Plakoglobin
Plakoglobin
gamma Catenin
Junction Plakoglobin
Desmoplakin III
gamma-Catenin

A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.


CAP102 Protein
alpha E-Catenin
alpha-Catulin
alpha-1 Catenin
alpha-Catenin
Cadherin-Associated Protein 102 kDa
alphaE Catenin
alpha Catenin

A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.


A segment of the COLON between the RECTUM and the descending colon.


DNA Restriction Enzymes
DNA Restriction Enzyme
Restriction Endonucleases
Restriction Endonuclease

Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.


Fluorinated Steroids
Steroids, Fluorinated

Steroids which are substituted with one or more fluorine atoms in any position.


VCAM-1
INCAM-110
Vascular Cell Adhesion Molecule
Vascular Cell Adhesion Molecule-1
Antigens, CD106
Inducible Cell Adhesion Molecule 110
CD106 Antigens
CD106 Antigen

Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)


One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.


Ribosomal Protein
Proteins, Ribosomal
Ribosomal Proteins

Proteins found in ribosomes. They are believed to have a catalytic function in reconstituting biologically active ribosomal subunits.


Vaccines, Contraceptive
Vaccines, Antifertility
Antifertility Vaccines
Contraceptive Vaccines

Vaccines or candidate vaccines used to prevent conception.


An exocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages of 1,4-beta-D-glucans resulting in successive removal of GLUCOSE units.


Nephrogenic Systemic Fibrosis
Nephrogenic Fibrosing Dermopathy

A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.


Rondomycin
Methacycline Monohydrochloride
Methacycline
Lysocline
Physiomycine
Metacycline
Methyleneoxytetracycline

A broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.


A genus comprised of nine species of small PARROTS from Africa. They are noted for showing affection for their mates.


In Situ Nick End-Labeling
In Situ Nick-End Labelling
In Situ Nick End-Labelling
In Situ Nick-End Labeling
Nick-End Labelling, In Situ
In Situ Nick End Labeling
Nick-End Labeling, In Situ
TUNEL
Nick End-Labeling, In Situ
Nick End-Labelling, In Situ
In Situ Nick End Labelling

An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.


Video-Assisted Thoracic Surgery
Surgery, Thoracic, Video-Assisted
VATS
Thoracic Surgery, Video-Assisted
Video-Assisted Thoracoscopic Surgery

Endoscopic surgery of the pleural cavity performed with visualization via video transmission.


Bovine Herpesvirus 2
Bovine Herpes Mammillitis Virus
Herpesvirus 2, Bovine
Ulcerative Mammillitis Virus, Bovine
Allerton Virus
Bovine Ulcerative Mammillitis Virus
BHM Virus
Herpes Mammillitis Virus, Bovine
Bovine Mamillitis Virus
Herpesvirus 2 (alpha), Bovine

A species of SIMPLEXVIRUS causing mammillitis in cattle in Great Britain and South Africa.


The epithelial lining of the URINARY TRACT.


Corpus Ciliare
Ciliary Body
Corpus Ciliaris

A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.


Multiple Personalities
Dissociative Identity Disorder
Multiple Personality Disorder
Dual Personality
Multiple Identity Disorder

A dissociative disorder in which the individual adopts two or more distinct personalities. Each personality is a fully integrated and complex unit with memories, behavior patterns and social friendships. Transition from one personality to another is sudden.


A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-amino acid from L-ornithine and a 2-keto-acid. EC 2.6.1.13.


Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor

A nuclear co-repressor protein that shows specificity for RETINOIC ACID RECEPTORS and THYROID HORMONE RECEPTORS. The dissociation of this co-repressor from nuclear receptors is generally ligand-dependent, but can also occur by way of its phosphorylation by members of the MAP KINASE SIGNALING SYSTEM. The protein contains two nuclear receptor interaction domains and four repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 1.


Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.


Ribosomal Spacer DNA
DNA, Ribosomal Spacer

The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).


Effort Syndrome
Neurocirculatory Asthenia
Cardiac Neurosis
Hyperkinetic Heart Syndrome

A clinical syndrome characterized by palpitation, SHORTNESS OF BREATH, labored breathing, subjective complaints of effort and discomfort, all following slight PHYSICAL EXERTION. Other symptoms may be DIZZINESS, tremulousness, SWEATING, and INSOMNIA. Neurocirculatory asthenia is most typically seen as a form of anxiety disorder.


Recognition (Psychology)
Recognition, Psychology
Psychological Recognition
Familiarity

The knowledge or perception that someone or something present has been previously encountered.


Immune Response-Associated Antigens, Human

Immune Response Associated Antigens, Human

Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.


Galactosylceramides
Galactosyl Ceramides
Galactocerebrosides

Cerebrosides which contain as their polar head group a galactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in beta-galactosidase, is the cause of galactosylceramide lipidosis or globoid cell leukodystrophy.


Mitral Valve Prolapse Syndrome
Mitral Click-Murmur Syndrome
Systolic Click-Murmur Syndrome
Mitral Valve Prolapse
Prolapsed Mitral Valve
Floppy Mitral Valve
Click-Murmur Syndrome

Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.


Fursultiamine
Fursultiamin Hydrochloride
Fursultiamin
Fursultiamin Monohydrochloride
Thiamine Tetrahydrofurfuryl Disulfide

Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful.


PGE Receptors
PGE2 Receptors
Prostaglandin E Receptor
PGE Receptor
Prostaglandin E Receptors
Receptors, Prostaglandin E

Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin E receptors prefer prostaglandin E2 to other endogenous prostaglandins. They are subdivided into EP1, EP2, and EP3 types based on their effects and their pharmacology.


SOS Induction
SOS Response (Genetics)
SOS System
SOS Box
SOS Repair
SOS Response, Genetics
SOS Function
SOS Region
SOS Response

An error-prone mechanism or set of functions for repairing damaged microbial DNA. SOS functions (a concept reputedly derived from the SOS of the international distress signal) are involved in DNA repair and mutagenesis, in cell division inhibition, in recovery of normal physiological conditions after DNA repair, and possibly in cell death when DNA damage is extensive.


Haversian System
Nutrient Canals
Volkmann Canals
Haversian Canals
Osteon

A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.


The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.


Laryngeal Perichondritis
Laryngeal Diseases
Larynx Diseases

Inflammation of LARYNGEAL CARTILAGES, usually due to infections.


ACTH 1-24
Corticotropin (1-24)-Tetracosapeptide
Tetracosapeptide
1-24-ACTH
Cortosyn
Tetracosactrin
1-24-Corticotropin
Synthetic ACTH
Corticotropin (1-24)-Peptide
Cortrosyn
Tetracosactide
Cosyntropin
ACTH (1-24)

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.


High Mobility Group Box Proteins
HMGB Proteins
HMGB
HMG-Box Proteins
HMG-B

A family of sequence-related proteins similar to HMGB1 PROTEIN that contains specific HMG-BOX DOMAINS.


Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.


Rubber Latex Allergy
Rubber Allergy
Natural Rubber Latex Allergy
Hypersensitivity, Latex
Latex Allergy
Allergy, Latex
Latex Hypersensitivity

Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.


Polynuclear Aromatic Hydrocarbons
Polycyclic Aromatic Hydrocarbons
Polycyclic Hydrocarbons, Aromatic

Aromatic hydrocarbons that contain extended fused-ring structures.


Goosecoid Protein
Goosecoid Homeodomain Protein
Goosecoid Transcription Factor

Goosecoid protein is a homeodomain protein that was first identified in XENOPUS. It is found in the SPEMANN ORGANIZER of VERTEBRATES and plays an important role in neuronal CELL DIFFERENTIATION and ORGANOGENESIS.


Spastic Lower Extremity Weakness
Lower Extremity Weakness, Spastic
Spastic Paraparesis
Paraparesis, Spastic

Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.


Kelch Repeat Type 2
Kelch Repeat
Kelch Repeats
Kelch Repeat Type 1
Kelch Motif
Kelch Domain

An amino acid sequence of about 50 residues long that is composed of X n-long repeats which form a four-stranded anti-parallel BETA-SHEET as a structural component, or blade, of a beta-propeller.


Theobroma
Cocoa Plant
Theobroma cacao
Cacao

A tree of the family MALVACEAE, order MALVALES, whose seeds are processed to yield COCOA and CHOCOLATE.


Ubiquitin, Human
APF-1
ATP-Dependent Proteolysis Factor 1
High Mobility Protein 20
Ubiquitin
HMG-20

A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.


Voltage-Gated Sodium Channel Stimulators

Compounds that either stimulate the opening or prevent closure of VOLTAGE-GATED SODIUM CHANNELS.


Adenosine Cyclic 3,5 Monophosphate
Cyclic AMP, (R)-Isomer
Adenosine Cyclic-3',5'-Monophosphate
Cyclic AMP, Monosodium Salt
Cyclic AMP, Monopotassium Salt
Cyclic AMP
Cyclic AMP, Sodium Salt
Adenosine Cyclic 3',5'-Monophosphate
Cyclic AMP, Monoammonium Salt
Adenosine Cyclic Monophosphate
Cyclic AMP, Disodium Salt

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.


Multispecific Organic Anion Transport Proteins

ATP-Binding Cassette, Sub-Family C Proteins

A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.


The genetic complement of a helminth (HELMINTHS) as represented in its DNA.


Human Herpesvirus 3
Herpesvirus 3 (alpha), Human
HHV-3
Ocular Herpes zoster Virus
VZ Virus
Herpes zoster Virus
Chickenpox Virus
Herpesvirus 3, Human
Varicella-Zoster Virus
Herpesvirus Varicellae

The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.


Integrin beta(4)
Antigens, CD104
CD104 Antigens
CD104 Antigen
Integrin beta4
beta4 Integrin

Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.


Cystadenoma Lymphomatosum, Papillary
Warthin Tumor
Adenolymphoma

A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.


2-Hydroxy-5-nitrobenzyl Bromide
Koshland's Reagent I
Koshlands Reagent
Koshland Reagent

A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules. Used for 'active site' enzyme studies and other protein studies. Sometimes referred to as Koshland's reagent.


Signal Recognition Particle
SRP (Signal Recognition Particle)

A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).


Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.


Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.


The excision of a cone of tissue, especially of the CERVIX UTERI.


Bacterial Chromosomes
Chromosomes, Bacterial
Chromosome, Bacterial
Bacterial Chromosome

Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.


KCNA6 Potassium Channel
HBK2 Potassium Channel
RCK2 Potassium Channel
Kv1.6 Potassium Channel

A delayed rectifier subtype of shaker potassium channels that has been described in NEURONS and ASTROCYTES.


Silubin
Butylbiguanide
Adebit
Silubin Retard
1-Butylbiguanide
Buformin
Gliporal

An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.


Synthetic Drugs
Synthetic Drug
Synthesized Drugs

Legal or illegal drugs created using SYNTHETIC CHEMISTRY TECHNIQUES.


Technetium diethylenetriamine pentaacetic acid

A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.


A form of pigmented nevus showing intense melanocytic activity around the dermo-epidermal junction. Large numbers of spindle-shaped melanocytes proliferate downward toward the dermis and usually a large amount of pigment is present. It was first described in 1976 and the bulk of patients reported have been young females with the lesions presenting on the thighs. (From Rook et al., Textbook of Dermatology, 4th ed, 1992, p185)


Education, Pharmaceutic, Graduate
Education, Graduate Pharmaceutic
Pharmacy Education, Graduate
Pharmaceutical Education, Graduate
Education, Pharmaceutical, Graduate
Graduate Pharmacy Education
Pharmaceutic Education, Graduate
Education, Pharmacy, Graduate
Education, Graduate Pharmaceutical

Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.


N-of-1 Trials as Topic
Single-Case Study
Single-Case Trial
Single-Case Studies as Topic
Single-Subject Trial

Trials that consider an individual patient as the sole unit of observation in a study investigating the efficacy or side-effects of different interventions to determine the optimal intervention for an individual patient using objective data-driven criteria.


Ophthalmoplegic Migraine
Ophthalmoplegic Migraine Syndrome

Childhood-onset of recurrent headaches with an oculomotor cranial nerve palsy. Typically, ABDUCENS NERVE; OCULOMOTOR NERVE; and TROCHLEAR NERVE are involved with DIPLOPIA and BLEPHAROPTOSIS.


Carcinoma, Bronchogenic
Carcinoma, Bronchial

Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.


Corticotropin Receptors
Adrenocorticotropic Hormone Receptors
Adrenocorticotropic Hormone Receptor
Receptors, ACTH
Receptors, Corticotropin
Corticotropin Receptor
Receptors, Adrenocorticotropic Hormone
ACTH Receptor
ACTH Receptors

Cell surface receptors that bind CORTICOTROPIN; (ACTH, adrenocorticotropic hormone) with high affinity and trigger intracellular changes. Pharmacology suggests there may be multiple ACTH receptors. An ACTH receptor has been cloned and belongs to a subfamily of G-protein-coupled receptors. In addition to the adrenal cortex, ACTH receptors are found in the brain and immune systems.


4-Dimethylaminoazobenzene
p-Dimethylaminoazobenzene, (E)-Isomer
Methyl Yellow
p-Dimethylaminoazobenzene
p-Dimethylaminoazobenzene, (Z)-Isomer
Dimethylaminoazobenzene
Butter Yellow

A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound "may reasonably be anticipated to be a carcinogen." (Merck, 11th ed)


Lymphotoxin alphabeta Heterotrimer
Lymphotoxin alpha1, beta2 Heterotrimer
Lymphotoxin alpha1beta2
Lymphotoxin alphabeta

A heterotrimer complex consisting of one molecule of LYMPHOTOXIN-ALPHA and two molecules of the LYMPHOTOXIN-BETA. It is anchored to the cell surface via the transmembrane domains of the lymphotoxin-beta component and has specificity for the LYMPHOTOXIN BETA RECEPTOR. The lymphotoxin alpha1, beta2 heterotrimer plays a role in regulating lymphoid ORGANOGENESIS and the differentiation of certain subsets of NATURAL KILLER CELLS.


Behavior pattern characterized by negative emotionality, an inability to express emotions, and social isolation, which has been linked to greater cardiovascular disease and increased mortality. (from International Encyclopedia of the Social Sciences, 2008, p. 217)


A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.


Weight Loss Trajectory
Weight Trajectory
Weight Change Trajectory
Body-Weight Trajectory
Weight Gain Trajectory

A general pattern of body weight gain or loss over many years. Weight change trajectory is influenced by several determinants in children and adults.


A cytotoxic member of the CYTOCHALASINS.


Melanoma Differentiation-Associated Protein 5

Interferon-Induced Helicase C Domain-Containing Protein 1

Interferon Induced with Helicase C Domain 1

A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.


Haematoxylon Hydroxybrazilin Hematoxylin Hydroxybrasilin Hematoxiline Hemotoxylin

A dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture of ink.


EGF
beta-Urogastrone
Epidermal Growth Factor-Urogastrone
Human Urinary Gastric Inhibitor
Urogastrone
Epidermal Growth Factor

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.


Lymphoma, T Cell, Cutaneous
Lymphoma, T-Cell, Cutaneous
Cutaneous T-Cell Lymphoma
T-Cell Lymphoma, Cutaneous
Granulomatous Slack Skin

A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.


Proteoglycan Type H
Proteoglycans
Proteoglycan

Glycoproteins which have a very high polysaccharide content.


Stomata, Surgical
Surgical Stomas
Surgical Stomata
Stomas, Surgical

Artificial openings created by a surgeon for therapeutic reasons. Most often this refers to openings from the GASTROINTESTINAL TRACT through the ABDOMINAL WALL to the outside of the body. It can also refer to the two ends of a surgical anastomosis.


Leukoplakic Lesions
Leukoplakia
Leukokeratosis

Leukoplakic lesions related to abnormal keratin fiber formation.


Pasteurella Infections
Pasteurellosis
Infections, Pasteurella

Infections with bacteria of the genus PASTEURELLA.


Psychophysiological Disorders
Psychosomatic Disorders
Psychophysiologic Disorders

A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)


A hexosiminidase that specifically hydrolyzes terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides.


Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.


A subcategory of structurally-related phospholipases A2 that do not require calcium for activity.


Immunoelectron Microscopy
Microscopy, Immunoelectron
Microscopy, Immuno-Electron

Microscopy in which the samples are first stained immunocytochemically and then examined using an electron microscope. Immunoelectron microscopy is used extensively in diagnostic virology as part of very sensitive immunoassays.


Tearing away of the CORTICAL BONE fragment at the location of a strong ligament or tendon attachment. The bone fragment detachment site often occurs near a soft site (e.g., GROWTH PLATE) at the base where LIGAMENTS; TENDONS; or JOINT CAPSULES attach. In younger patients it is most often caused by a sudden forceful pull on a tendon in the opposite direction of the bone movement. In the elderly it is associated with osteoporotic INSUFFICIENCY FRACTURES.


Occupational Exposure
Exposure, Occupational

The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.


Sclerosis, Progressive Systemic
Diffuse Scleroderma
Scleroderma, Progressive
Sudden Onset Scleroderma
Diffuse Systemic Sclerosis
Scleroderma, Diffuse
Diffuse Cutaneous Systemic Sclerosis

A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.


Usually a hydroxide of lithium, sodium, potassium, rubidium or cesium, but also the carbonates of these metals, ammonia, and the amines. (Grant & Hackh's Chemical Dictionary, 5th ed)


A genus of fungi in the family Neocallimasticaceae, order NEOCALLIMASTICALES, containing uniflagellate zoospores.


Polyploidy with three sets of chromosomes. Triploidy in humans are 69XXX, 69XXY, and 69XYY. It is associated with HOLOPROSENCEPHALY; ABNORMALITIES, MULTIPLE; PARTIAL HYDATIDIFORM MOLE; and MISCARRAGES.


A highly poisonous compound used widely in the manufacture of plastics, adhesives and synthetic rubber.


Carcinoma, Intraductal, Noninfiltrating
Intraductal Carcinoma, Noninfiltrating
DCIS
Atypical Ductal Hyperplasia
Carcinoma, Intraductal
Ductal Carcinoma In Situ

A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.


Ocular Prosthesis
Eye, Artificial
Artificial Eye

A ready-made or custom-made prosthesis of glass or plastic shaped and colored to resemble the anterior portion of a normal eye and used for cosmetic reasons. It is attached to the anterior portion of an orbital implant (ORBITAL IMPLANTS) which is placed in the socket of an enucleated or eviscerated eye. (From Dorland, 28th ed)


Serological Tests
Serodiagnosis
Tests, Serologic
Serologic Tests
Serologic Test
Test, Serologic

Diagnostic procedures involving immunoglobulin reactions.


Infraclass of ancient winged insects belonging to the subclass PTERYGOTA.


Transplantation, Neoplasm
Neoplasm Transplantation

Experimental transplantation of neoplasms in laboratory animals for research purposes.


AQP4 Protein
Aquaporin 4
Aquaporin 4 Protein

Aquaporin 4 is the major water-selective channel in the CENTRAL NERVOUS SYSTEM of mammals.


Spondylarthritis
Arthritis, Spinal
Spinal Arthritis

Inflammation of the joints of the SPINE, the intervertebral articulations.


Aldose-Ketose Isomerases
Ketose-Aldose Isomerases

Enzymes that catalyze the interconversion of aldose and ketose compounds.


Peptide Biosynthesis, Nucleic Acid-Independent

Nucleic Acid-Independent Peptide Biosynthesis

Peptide Biosynthesis, Thiotemplate Mechanism

The enzymatic synthesis of PEPTIDES without an RNA template by processes that do not use the ribosomal apparatus (RIBOSOMES).


The medical specialty which deals with WOUNDS and INJURIES as well as resulting disability and disorders from physical traumas.


Metabolic Detoxication, Phase I
Phase I Detoxification
Metabolic Detoxification, Phase I
Metabolic Detoxication, Oxidative

Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.


Aneurysm, False
Pseudoaneurysm
False Aneurysm

Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.


Guttapercha Gutta-Percha Thermafil Ultrafil

Coagulated exudate isolated from several species of the tropical tree Palaquium (Sapotaceae). It is the trans-isomer of natural rubber and is used as a filling and impression material in dentistry and orthopedics and as an insulator in electronics. It has also been used as a rubber substitute.


Fenmetrazin
Preludin
Phenmetrazine
Phenmetraline
Phenmetrazine Hydrochloride
Defenmetrazin
Oxazimedrine

A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.


Troponin-T
Troponin T1
Troponin T2
Troponin T3
Troponin T

A TROPONIN complex subunit that binds to TROPOMYOSIN. There are three troponin T subtypes: troponin T1, T2 and T3. Troponin T2 is cardiac-specific whereas troponin T2 and T3 are skeletal subtypes. Troponin T2 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin T2 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.


Influenza A Virus, H5N8 Subtype
H5N8 Virus

A subtype of INFLUENZA A VIRUS that is highly virulent in poultry and wild birds, but shows varying degrees of pathogenicity in mice. The H5N8 virus subtype has a polybasic amino acid motif at the HA cleavage site which explains its pathogenicity in birds, and expresses surface proteins HEMAGGLUTININ 5 and NEURAMINIDASE 8 which are typical of Highly Pathogenic Avian Influenza viruses.


Calcium and Phospholipid-Binding Protein p68

Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.


Cathartics
Purgatives
Bowel Preparation Solutions
Bowel Evacuants

Agents that are used to stimulate evacuation of the bowels.


Histamine H3 Receptor Antagonists
Antihistaminics, H3
Histamine H3 Antagonists
Histamine H3 Blockers

Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to correct SLEEP WAKE DISORDERS and MEMORY DISORDERS.


An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.


The functional genetic units of ARCHAEA.


The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.


Lateral displacement of the great toe (HALLUX), producing deformity of the first METATARSOPHALANGEAL JOINT with callous, bursa, or BUNION formation over the bony prominence.


v-Rel Reticuloendotheliosis Viral Oncogene Homolog B

A transcription factor that takes part in the NF-kappa-B complex by interacting with NF-KAPPA B P50 SUBUNIT or NF-KAPPA B P52 SUBUNIT. It regulates GENETIC TRANSCRIPTION that is involved in immune and inflammatory responses.


Lyme Arthritis
B. burgdorferi Infection
Lyme Borreliosis
Borrelia burgdorferi Infection
Lyme Disease

An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.


Skin diseases of the foot, general or unspecified.


Simian Acquired Immuno-Deficiency Syndrome

Simian Acquired Immune Deficiency Syndrome

Simian Acquired Immunodeficiency Syndrome

Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.


Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome

A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34 amino acid tetratricopeptide repeats. These domains, also found in Apc3, Apc7, and Apc8, have been shown to mediate protein-protein interactions, suggesting that Apc6 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.


An enzyme present in nerve tissue. It catalyzes reversibly the formation of thiamine diphosphate and orthophosphate from thiamine triphosphate. EC 3.6.1.28.


Chemicals that are used to oxidize pigments and thus effect whitening.


Triggering Receptor Expressed on Myeloid Cells-1

An approximately 230 amino acid membrane glycoprotein characterized by an IMMUNOGLOBULIN V-SET DOMAIN in its N-terminal half. It is expressed by MONOCYTES and NEUTROPHILS in response to INFLAMMATION related to bacterial and fungal infections. It triggers the release of pro-inflammatory CHEMOKINES; CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK.


Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria, plastids, and plasmids. Small, polydisperse circular DNA's have also been observed in a number of eukaryotic organisms and are suggested to have homology with chromosomal DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is a fragment of DNA formed by a process of looping out and deletion, containing a constant region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA is a normal product of rearrangement among gene segments encoding the variable regions of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)


A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.


Mental Retardation with Osteocartilaginous Abnormalities

A rare, X-linked INTELLECTUAL DISABILITY syndrome that results from mutations in the RIBOSOMAL PROTEIN S6 KINASE gene. Typical manifestations of the disease include an intelligence quotient of less than 50, facial anomalies, and other malformations.


A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.


Wnt-3A Protein
Wnt3A Protein
Wnt-3 Proteins

A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE.


Antigens from any of the hepatitis viruses including surface, core, and other associated antigens.


Bite Force
Masticatory Force
Occlusal Force

The force applied by the masticatory muscles in dental occlusion.


Monocular Vision
Monovision
Vision, Monocular


The doctrines and policies of the Nazis or the National Social German Workers party, which ruled Germany under Adolf Hitler from 1933-1945. These doctrines and policies included racist nationalism, expansionism, and state control of the economy. (from Columbia Encyclopedia, 6th ed. and American Heritage College Dictionary, 3d ed.)


Cysteine Proteinase
Cysteine Proteinases
Cysteine Proteases
Cysteine Protease

A subclass of peptide hydrolases that depend on a CYSTEINE residue for their activity.


Psychotropic Drugs
Psychopharmaceuticals
Psychoactive Agents
Psychoactive Drugs

A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).


Bephenium Derivatives
Bephenium Compounds

Analogs or derivatives of bephenium (N,N-dimethyl-N-(2-phenoxyethyl)benzenemethanaminium).


Physicians' Assistants
Doctor's Assistants
Feldshers
Physician Assistants
Physicians' Extenders

Health professionals who practice medicine as members of a team with their supervising physicians. They deliver a broad range of medical and surgical services to diverse populations in rural and urban settings. Duties may include physical exams, diagnosis and treatment of disease, interpretation of tests, assist in surgery, and prescribe medications. (from http://www.aapa.orglabout-pas accessed 2114/2011)


Chronic Actinic Dermatitis
Photodermatitis
Photosensitization
Photosensitivity Disorders
Dermatitis, Actinic
Actinic Reticuloid Syndrome

Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.


Primary Care
Primary Health Care
Primary Healthcare

Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community. (JAMA 1995;273(3):192)


Heparin-Binding Growth Associated Molecule Receptor

A syndecan found at high levels in the developing LIMB BUDS. It may play a role in the regulation of MUSCULOSKELETAL DEVELOPMENT by modulating the effects of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.


Episodic Cluster Headache
Chronic Cluster Headache
Neuralgic Migraine
Headache, Cluster
Horton Syndrome
Horton's Syndrome
Histamine Cephalgia
Cluster Headache Syndrome
Ciliary Neuralgia
Cluster Headache
Atypical Cluster Headache

A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)


Purinergic Antagonists
Purinoceptor Antagonists
Purinergic Receptor Antagonists

Drugs that bind to and block the activation of PURINERGIC RECEPTORS.


A benign tumor of the intrahepatic bile ducts.


Genital Diseases, Male
Male Genital Diseases

Pathological processes involving the male reproductive tract (GENITALIA, MALE).


beta-Lactam Resistance
beta-Lactam Resistant
beta-Lactamase Resistant
beta-Lactamase Resistance

Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.


Contraceptives, Female
Contraceptive Agents, Female

Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.


A subclass of heme a containing cytochromes that have two imidazole nitrogens as axial ligands and an alpha-band absorption of 605 nm. They are found in a variety of microorganisms and in eucaryotes as a low-spin cytochrome component of MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.


Sotos' Syndrome
Sotos Syndrome
Sotos Sequence
Cerebral Gigantism

Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.


PGD2
11-Dehydroprostaglandin F2alpha
Prostaglandin D2
11-Dehydroprostaglandin F2 alpha

The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.


Purine Pyrimidine Metabolism, Inborn Errors

Purine-Pyrimidine Metabolism, Inborn Errors

Dysfunctions in the metabolism of PURINES or PYRIMIDINES resulting from inborn genetic mutations that are inherited or acquired in utero.


TIMP-3 Protein
Tissue Inhibitor of Metalloproteinase-3
TIMP3 Protein
TIMP-3

A member of the family of tissue inhibitor of metalloproteinases. Mutations of the gene for TIMP3 PROTEIN causes Sorsby fundus dystrophy.


Fluorinated Hydrocarbons
Hydrocarbons, Fluorinated

Inert liquid or gaseous halocarbon compounds in which FLUORINE replaces some or all HYDROGEN atoms.


rho Guanine Nucleotide Dissociation Inhibitors

rho-Specific Guanine Nucleotide Dissociation Inhibitors

A subcategory of guanine nucleotide dissociation inhibitors that are specific for RHO GTP-BINDING PROTEINS.


ChTX
Quinquestriatus Toxin
CTX Toxin
Charybdotoxin

A 37-amino acid residue peptide isolated from the scorpion Leiurus quinquestriatus hebraeus. It is a neurotoxin that inhibits calcium activated potassium channels.


Protein Kinase A Anchor Proteins
A-Kinase Anchor Proteins
A Kinase Anchor Proteins

A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A subtypes to distinct subcellular sites. They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA.


Host Species Specificity
Host Range
Host Specificity

The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.


Sucralfate
Ulsanic
Carafate
Ulcogant
Antepsin
Ulcerban
Basic Aluminum Sucrose Sulfate
Aluminum Sucrose Sulfate

A basic aluminum complex of sulfated sucrose.


A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.


Monkey, Ring-Tail
Cebus
White-Fronted Capuchin
Monkey, Ringtail
Monkey, Ring-Tailed
Gracile Capuchins
Monkey, Ringtailed
Monkey, Capuchin
Untufted Capuchins

A genus of the family CEBIDAE, subfamily CEBINAE, consisting of gracile or untufted capuchin species. Tufted capuchins belong to genus SAPAJUS. Members include C. capucinus, C. nigrivultatus, and C. albifrons. Cebus inhabits the forests of Central and South Americas.


Receptor, Type 5 Fibroblast Growth Factor

Receptor, Fibroblast Growth Factor, Type 5

The most divergent of the known fibroblast growth factor receptors. It does not contain an intracellular TYROSINE KINASE domain and has been shown to interact with FIBROBLAST GROWTH FACTOR 2. Fibroblast growth factor receptor 5 is found primarily in skeletal tissue.


Adenosine Triphosphate-Dependent Proteolytic System

Proteases that contain proteolytic core domains and ATPase-containing regulatory domains. They are usually comprised of large multi-subunit assemblies. The domains can occur within a single peptide chain or on distinct subunits.


Natural Killer Cell Lectin-Like Receptors

Structurally-related receptors that are typically found on NATURAL KILLER CELLS. They are considered lectin-like proteins in that they share sequence homology with the carbohydrate binding domains of C-TYPE LECTINS. They differ from classical C-type lectins, however, in that they appear to lack CALCIUM-binding domains.


A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.


Chest Injuries
Thoracic Injuries
Injuries, Chest
Injuries, Thoracic

General or unspecified injuries to the chest area.


rho GTPases
P21 (rho)Protein
rho Protein P21
rho GTP-Binding Protein
rho G-Proteins
rho GTP-Binding Proteins
rho Small GTP-Binding Proteins

A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 3.6.1.47.


H Blood Group System
ABO Factors
H Blood Group
ABH Blood Group
Blood Group H Type 1 Antigen
ABO Blood-Group System

The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.


A large family of transmembrane proteins found in TIGHT JUNCTIONS. They take part in the formation of paracellular barriers and pores that regulate paracellular permeability.


Channel-Forming Integral Membrane Protein Of 28 kDa

Aquaporin 1 forms a water-specific channel that is constitutively expressed at the PLASMA MEMBRANE of ERYTHROCYTES and KIDNEY TUBULES, PROXIMAL. It provides these cells with a high permeability to WATER. In humans polymorphisms of this protein result in the Colton blood group antigen.


Monoamines, Biogenic
Biogenic Monoamines

Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.


Injuries involving the vertebral column.


Glutamate Ammonia Ligase (ADP)
Glutamine Synthetase
Glutamate-Ammonia Ligase

An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.


A plant species of the genus MELIA, family MELIACEAE, which is toxic to insects. The name is very similar to Melia azadirachta (AZADIRACHTA).


Gram-Negative Aerobic Rods and Cocci
Gram Negative Aerobic Rods and Cocci

A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.


DNA-Binding Protein Inhibitor ID1
Inhibitor of DNA Binding Protein 1
Inhibitor of Differentiation Protein 1

A HELIX-LOOP-HELIX MOTIF-containing negative regulator of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS that blocks activation of CYCLIN-DEPENDENT KINASE INHIBITOR P16 and is de-regulated in a variety of NEOPLASMS.


Epidural Blood Patch
Blood Patch, Epidural

The injection of autologous blood into the epidural space either as a prophylactic treatment immediately following an epidural puncture or for treatment of headache as a result of an epidural puncture.


A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.


Salmonella enterica serovar Paratyphi A
Salmonella paratyphi A
Salmonella paratyphi

A serotype of SALMONELLA ENTERICA that causes mild PARATYPHOID FEVER in humans.


One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.


Sick House Syndrome
Sick Building Syndrome

A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (ALVEOLITIS, EXTRINSIC ALLERGIC); allergic rhinitis (RHINITIS, ALLERGIC, PERENNIAL); ASTHMA; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)


A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA.


Random Amplified Polymorphic DNA Technic

Random Amplified Polymorphic DNA Technique

Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.


Albinism, Partial
Albinism, Cutaneous
Piebaldism
Piebald Trait

Autosomal dominant, congenital disorder characterized by localized hypomelanosis of the skin and hair. The most familiar feature is a white forelock presenting in 80 to 90 percent of the patients. The underlying defect is possibly related to the differentiation and migration of melanoblasts, as well as to defective development of the neural crest (neurocristopathy). Piebaldism may be closely related to WAARDENBURG SYNDROME.


Increase in the mass of bone per unit volume.


Cytochromes Type a
Cytochrome a Group
Cytochromes, Heme a

Cytochromes (electron-transporting proteins) in which the heme prosthetic group is heme a, i.e., the iron chelate of cytoporphyrin IX. (From Enzyme Nomenclature, 1992, p539)


Exotoxins produced by certain strains of streptococci, particularly those of group A (STREPTOCOCCUS PYOGENES), that cause HEMOLYSIS.


Cyclophilin-40
Cyclophilin D
Peptidyl-Prolyl Isomerase F
PPIF Cyclophilin
Cyclophilin 40

A member of the cyclophilins family of isomerases which plays a role in the regulation of the permeability transition pore in mitochondria.


Periodic movements of animals in response to seasonal changes or reproductive instinct. Hormonal changes are the trigger in at least some animals. Most migrations are made for reasons of climatic change, feeding, or breeding.


Viral Non-Structural Proteins
Viral Nonstructural Proteins NS1
Nonstructural Proteins, Viral
Viral NS Proteins
Viral Nonstructural Proteins
Viral Nonstructural Protein
Viral Nonstructural Proteins NS2
NS Proteins, Viral

Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.


Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.


Insemination, Artificial, Heterologous
Artificial Insemination, Donor
Insemination, Artificial, Human Donor
Insemination, Heterologous
AID
Heterologous Insemination

Human artificial insemination in which the semen used is that of a man other than the woman's husband.


Auditory Localization
Sound Localization

Ability to determine the specific location of a sound source.


Episodes of Care
Patient Care Episodes
Episode of Care

An interval of care by a health care facility or provider for a specific medical problem or condition. It may be continuous or it may consist of a series of intervals marked by one or more brief separations from care, and can also identify the sequence of care (e.g., emergency, inpatient, outpatient), thus serving as one measure of health care provided.


Reovirus Infections
Reoviridae Infections
Infections, Reoviridae

Infections produced by reoviruses, general or unspecified.


Brucella melitensis biovar ovis
Brucella ovis

A species of the genus BRUCELLA which are pathogenic to SHEEP.


Enterobacteria phage T7
Phage T7
Coliphage T7
Bacteriophage T7
T7 Phage

Virulent bacteriophage and type species of the genus T7-like phages, in the family PODOVIRIDAE, that infects E. coli. It consists of linear double-stranded DNA, terminally redundant, and non-permuted.


PKC-delta Serine-Threonine Kinase
Protein Kinase C-delta

A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of signaling protein tyrosine kinase.


Penile Prosthesis
Prosthesis, Penile
Penile Implant
Artificial Penis
Penis, Artificial
Penis Prosthesis

Rigid, semi-rigid, or inflatable cylindric hydraulic devices, with either combined or separate reservoir and pumping systems, implanted for the surgical treatment of organic ERECTILE DYSFUNCTION.


Caring for self when ill or positive actions and adopting behaviors to prevent illness.


Cerebral Cholesterinosis
Van Bogaert-Scherer-Epstein Disease
Cerebrotendinous Xanthomatosis
Xanthomatosis, Cerebrotendinous

An autosomal recessive lipid storage disorder due to mutation of the gene CYP27A1 encoding a CHOLESTANETRIOL 26-MONOOXYGENASE. It is characterized by large deposits of CHOLESTEROL and CHOLESTANOL in various tissues resulting in xanthomatous swelling of tendons, early CATARACT, and progressive neurological symptoms.


Adenosine Receptor Agonists
P1 Purinoceptor Agonists
Purinergic P1 Receptor Agonists

Compounds that bind to and stimulate PURINERGIC P1 RECEPTORS.


Etomidate R-26490 Ethomidate Hypnomidate Radenarkon

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.


Chlorpropham
Isopropyl N-(3-Chlorophenol)carbamate
CIPC

A carbamate that is used as an herbicide and as a plant growth regulator.


Tracheophyta Conifers Tracheobionta Pinophyta Coniferophyta Pteridophyta

A subset of plants bearing a vascular system. Examples are ferns and seed-bearing species.


Immune Regeneration
Immune Restoration
Immune Reconstitution

Regeneration of normal immune function after immune depleting procedures or infections (e.g., HEMATOPOIETIC STEM CELL TRANSPLANTATION). Delayed and incomplete reconstitution of the ADAPTIVE IMMUNE system in particular involving T-CELLS is associated with increase or relapse of infection.


Pancreatic Islets
Pancreas, Endocrine
Nesidioblasts
Islands of Langerhans
Islets of Langerhans
Islet Cells

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.


A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.


Works about images used to comment on such things as contemporary events, social habits, or political trends; usually executed in a broad or abbreviated manner.


Molecules, Pathogen-Associated Molecular Pattern

Pathogen-Associated Molecular Pattern Molecules

Sequences in molecules of pathogens that are recognized by PATTERN RECOGNITION RECEPTORS.


Periodontal Debridement
Nonsurgical Periodontal Debridement
Periodontal Pocket Debridement

Removal or disruption of DENTAL DEPOSITS and plaque-retentive DENTAL CALCULUS from tooth surfaces and within the periodontal pocket space without deliberate removal of CEMENTUM as done in ROOT PLANING and often in DENTAL SCALING. The goal is to conserve dental cementum to help maintain or re-establish healthy periodontal environment and eliminate PERIODONTITIS by using light instrumentation strokes and nonsurgical techniques (e.g., ultrasonic, laser instruments).


Polypeptide Hormones
Hormones, Peptide
Peptide Hormones

Hormones synthesized from amino acids. They are distinguished from INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS in that their actions are systemic.


ET Flavoprotein
Electron-Transferring Flavoproteins
Electron-Transferring Flavoprotein
Electron Transfer Flavoprotein

Flavoproteins that serve as specific electron acceptors for a variety of DEHYDROGENASES. They participate in the transfer of electrons to a variety of redox acceptors that occur in the respiratory chain.


Activation Analysis
Analysis, Activation

A method of chemical analysis based on the detection of characteristic radionuclides following a nuclear bombardment. It is also known as radioactivity analysis. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Industry, Food-Processing
Food-Processing Industry

The productive enterprises concerned with food processing.


IL-7 Receptor
Receptors, Interleukin-7
IL7 Receptor
Interleukin 7 Receptor
Interleukin-7 Receptors
Receptors, IL-7
IL7 Receptors
IL-7 Receptors

Cell surface receptors that are specific for INTERLEUKIN-7. They are present on T-LYMPHOCYTES and B-LYMPHOCYTE precursors. The receptors are heterodimeric proteins consisting of the INTERLEUKIN-5 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR COMMON BETA SUBUNIT.


An immortalized cell line derived from human ADENOCARCINOMA, ALVEOLAR basal epithelial cells isolated from the lungs of a male patient in 1972. The cell line is positive for KERATIN, can synthesize LECITHIN, and contains high levels of POLYUNSATURATED FATTY ACIDS in its PLASMA MEMBRANE. It is used as a model for PULMONARY ALVEOLI function and virus infections, as a TRANSFECTION host, and for PRECLINICAL DRUG EVALUATION.


Acrogranin
Progranulin
Progranulins
Granulin Precursor
PC Cell-Derived Growth Factor
Granulin Precursor Protein
Proepithelin

Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.


A cyclic octapeptide with a thioether bridge between the cystine and tryptophan. It inhibits RNA POLYMERASE II. Poisoning may require LIVER TRANSPLANTATION.


Analysis, Mass Spectrum
Mass Spectroscopy
Spectrometry, Mass
Spectrum Analysis, Mass
Spectroscopy, Mass
Mass Spectrometry
Mass Spectrum Analysis

An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.


Echinoderms having bodies of usually five radially disposed arms coalescing at the center.


Pregnane derivatives in which two side-chain methyl groups or two methylene groups in the ring skeleton (or a combination thereof) have been oxidized to keto groups.


Mice, Knock-out
Mice, Knockout
Mouse, Knockout
Knockout Mice

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.


Mouse, Inbred AKR
Mice, Inbred AKR
Mice, AKR
Mouse, AKR

An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.


A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.


Nicotinamide Riboside Phosphorylase
Inosine Phosphorylase
Purine Nucleoside Phosphorylases
Purine-Nucleoside Phosphorylase

An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.


A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)


Compounds that increase urine volume by increasing the amount of osmotically active solute in the urine. Osmotic diuretics also increase the osmolarity of plasma.


The radioactive isotope of hydrogen also known as hydrogen-3. It contains two NEUTRONS and one PROTON in its nucleus and decays to produce low energy BETA PARTICLES.


Abnormal passage communicating with the STOMACH.


An imbalanced NUTRITIONAL STATUS resulting from excessive intake of nutrients. Generally, overnutrition generates an energy imbalance between food consumption and energy expenditure leading to disorders such as OBESITY.


Alkylated DNA Repair Protein AlkB Homolog 3

AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase

Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3

A dioxygenase and alkylation repair homolog that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. It has a strong preference for SINGLE-STRANDED DNA and may also act on RNA.


Proteins found in the LUNG that act as PULMONARY SURFACTANTS.


Glycol Methacrylate Gel
Polyglycol Methacrylate
Hydroxymethacrylate Gel
PHEMA
Polyhydroxyethyl Methacrylate
Poly-Hema

A biocompatible, hydrophilic, inert gel that is permeable to tissue fluids. It is used as an embedding medium for microscopy, as a coating for implants and prostheses, for contact lenses, as microspheres in adsorption research, etc.


Medfly
Fruit Fly, Mediterranean
Ceratitis capitata
Mediterranean Fruit Fly

A species of fruit fly originating in sub-Saharan Africa but widely distributed worldwide. One of the most destructive fruit pests, its larvae feed and develop on many different fruits and some vegetables.


Tumor Necrosis Factor Receptor Superfamily, Member 14

Tumor Necrosis Factor Receptor Subfamily, Member 14

Receptors, Tumor Necrosis Factor, Member 14

A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Passive Cutaneous Anaphylaxis
PCA
Anaphylaxis, Passive Cutaneous

An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.


That part of the genome that corresponds to the complete complement of EXONS of an organism or cell.


Substances or materials used in the course of housekeeping or personal routine.


Skin Diseases, Genetic
Genetic Skin Diseases

Diseases of the skin with a genetic component, usually the result of various inborn errors of metabolism.


Dental Care for Children
Dentistry for Children

The giving of attention to the special dental needs of children, including the prevention of tooth diseases and instruction in dental hygiene and dental health. The dental care may include the services provided by dental specialists.


Andersen Cardiodysrythmic Periodic Paralysis

Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, and Dysmorphic Features

Andersen Cardiodysrhythmic Periodic Paralysis

Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type

A form of inherited long QT syndrome (or LQT7) that is characterized by a triad of potassium-sensitive periodic paralysis, VENTRICULAR ECTOPIC BEATS, and abnormal features such as short stature, low-set ears, and SCOLIOSIS. It results from mutations of KCNJ2 gene which encodes a channel protein (INWARD RECTIFIER POTASSIUM CHANNELS) that regulates resting membrane potential.


An anti-inflammatory glucocorticoid used in veterinary practice.


Persistent pain that is refractory to some or all forms of treatment.


Horses
Horse, Domestic
Equus caballus
Equus przewalskii

Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.


Bilateral dissection of the abdominal branches of the vagus nerve. It is used frequently in the surgical management of duodenal and gastric ulcers, as well as in physiologic studies of gastrointestinal secretion and motility.


Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.


Dopamine D2 Receptors
Dopamine-D2 Receptor
Receptors, Dopamine D2

A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.


Craniomaxillofacial Fibrous Dysplasia
Fibrous Dysplasia, Craniofacial
Maxillary Fibrous Dysplasia
Fibrous Dysplasia of Skull
Craniofacial Fibrous Dysplasia

Mostly benign fibro-osseous proliferation of the facial bones and skull. It can be either monostotic (localized to a single bone) or polyostotic (localized to more than one bone) type.


Bis(nitrato-O)dioxouranium. A compound used in photography and the porcelain industry. It causes severe renal insufficiency and renal tubular necrosis in mammals and is an effective lymphocyte mitogen.


tRNAIle
Transfer RNA, Ile
Isoleucine-Specific tRNA
RNA, Transfer, Ile
tRNA(Ile)

A transfer RNA which is specific for carrying isoleucine to sites on the ribosomes in preparation for protein synthesis.


Corneal Angiogenesis
Corneal Neovascularization

New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.


Nurse's Role
Nurses Role
Nurses' Role
Nurse's Scope of Practice

The expected function of a member of the nursing profession.


Fern, Licorice
Polypodium
Fern, Calaguala

A plant genus of the family POLYPODIACEAE. Members contain polypodoside.


Pulmonary and Activation-Regulated Chemokine

A CC-type chemokine highly expressed in the lungs, lymph nodes, placenta, and bone marrow; it is also expressed by DENDRITIC CELLS in the GERMINAL CENTER, and peripheral blood MACROPHAGES. It functions as a chemotactic factor that specifically attracts LYMPHOCYTES, especially B-Cells, into lymph node follicles, and naive T-cells towards dendritic cells and activated T-cells. It does not attract MONOCYTES or GRANULOCYTES.


Alcoholic Fatty Liver
Fatty Liver, Alcoholic
Alcoholic Steatohepatitis

Lipid infiltration of the hepatic parenchymal cells that is due to ALCOHOL ABUSE. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of TRIGLYCERIDES accumulated.


A drugless system of therapy, making use of physical forces such as air, light, water, heat, massage. Treatments are often diet- and nutrition-oriented with attention given to the patient's personal history and lifestyle. (From Cassileth, Alternative Medicine Handbook, 1998, p329)


Pyridoxal-P
Pyridoxal 5-Phosphate
Pyridoxal Phosphate

This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).


The combination of genetic and optical methods in controlling specific events with temporal precision in targeted cells of a functioning intact biological system.


Junctional Adhesion Molecule
Junctional Adhesion Molecules
Junction Adhesion Molecule

A family of membrane glycoproteins localized to TIGHT JUNCTIONS that contain two extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail of variable length.