Cytochrome P-450-Dependent Monooxygenase Inhibitors

Cytochrome P-450 Monooxygenase Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 ENZYMES.


Cefepime Hydrochloride
Cefepime
BMY-28142
BMY 28142
Maxipime
Quadrocef
Cefepim
Axépim

A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.


Fecal Impaction
Fecalith
Feces, Impacted

Formation of a firm impassable mass of stool in the RECTUM or distal COLON.


Granulin A
Granulin (123-179)
Granulin 2
Granulins
Granulin 3
Granulin Peptides
Epithelin 5
Granulin G
Granulin F
Granulin 1
Granulin B
Epithelin-2
Granulin (206-261)
Granulin Peptide (281-336)
Epithelin-1
Epithelin 4
Granulin3
Paragranulin
Granulin 4
Granulin E
Granulin C
Epithelins
Granulin 7
Granulin-3
Granulin 5
Granulin D
Epithelin2
Epithelin 1
Granulin Peptide (58 -113)
Epithelin 2
Epithelin 3
Granulin 6

Granulin from the fourth granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin A or epithelin 1.


Dentinogenesis Imperfecta, Shields Type II

Dentinogenesis Imperfecta, Shields Type 2

Opalescent Teeth without Osteogenesis Imperfecta

Dentinogenesis Imperfecta without Osteogenesis Imperfecta

An autosomal dominant disorder of tooth development characterized by opalescent dentin resulting in discoloration of the teeth. The dentin develops poorly with low mineral content while the pulp canal is obliterated.


Hemophilus Infections
Haemophilus influenzae Infection
Haemophilus influenzae Type b Infection
Haemophilus Infections
Hib Infection
Infections, Hemophilus
Infections, Haemophilus

Infections with bacteria of the genus HAEMOPHILUS.


Distemper
Canine Distemper
Distemper, Canine

A name for several highly contagious viral diseases of animals, especially canine distemper. In dogs, it is caused by the canine distemper virus (DISTEMPER VIRUS, CANINE). It is characterized by a diphasic fever, leukopenia, gastrointestinal and respiratory inflammation and sometimes, neurologic complications. In cats it is known as FELINE PANLEUKOPENIA.


Cocaine Addiction
Cocaine-Related Disorders
Cocaine Dependence
Cocaine Abuse

Disorders related or resulting from use of cocaine.


Aphonia
Absence of Voice
Aphonia Paralytica
Nonorganic Aphonia
Functional Aphonia
Spastic Aphonia

Complete loss of phonation due to organic disease of the larynx or to nonorganic (i.e., psychogenic) causes.


Choline Bitartrate
Vidine
Fagine
Choline Hydroxide
Bursine
2-Hydroxy-N,N,N-trimethylethanaminium
Choline Chloride
Choline
Choline Citrate
Choline O-Sulfate

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.


Mammographic Breast Density
Mammographic Density
Breast Density

Measurement of relative composition of different BREAST tissue types often determined from MAMMOGRAPHY; ULTRASONOGRAPHY; or MRI.


Formalinized Allergoid
Allergoid
HMW-GOID
Formalized Allergoid
Allergoids
High Molecular Weight Allergoid

Extracts of allergens, or purified allergens that have been chemically modified to reduce their ability to induce IGE-MEDIATED HYPERSENSITIVITY (allergenicity) while increasing their ability to induce IMMUNE TOLERANCE.


Azorubin S
C.I. Food Red 9
Acid Red 27
AR27 Compound
C.I. Acid Red 27
Red Dye No. 2
FD & C Red No. 2
Amaranth Dye

A sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics. (From Merck Index, 11th ed)


Accidents, Biohazard
Accidents, Biological
Incidents, Biological
Biohazard Release
Accidental Release, Biological

Uncontrolled release of biological material from its containment. This either threatens to, or does, cause exposure to a biological hazard. Such an incident may occur accidentally or deliberately.


2-Aminobenzoates
ortho-Aminobenzoates
o-Aminobenzoic Acids
ortho-Aminobenzoic Acids
Anthranilic Acids
o-Aminobenzoates
Anthranilates
6-Aminobenzoates

Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.


Parainfluenza Virus Type 3
Parainfluenza Virus 3, Human
Para-Influenza Virus Type 3
Hemadsorption Virus 1
Human parainfluenza virus 3

A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.


Whole Exome Sequencing
Complete Transcriptome Sequencing
Whole Transcriptome Sequencing
Complete Exome Sequencing

Techniques to determine the complete complement of sequences of all EXONS of an organism or individual.


Genotype-Phenotype Correlation
Gene Discovery
Candidate Gene Identification
Genetic Association Studies
Candidate Gene Association Study
Genotype-Phenotype Correlations
Genotype-Phenotype Associations
Candidate Gene Analysis
Genotype-Phenotype Association
Candidate Gene Association Studies

Genetic variants (specific mutations or allelles of genes) and their corresponding phenotypic variations in the trait or the disease which the genes controls.


Deoxycholylglycine
Glycodeoxycholate
Glycodeoxycholic Acid
Glycine Deoxycholate

A bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.


Pustulosis of Palms and Soles
Psoriasis
Pustulosis Palmaris et Plantaris
Pustular Psoriasis of Palms and Soles
Palmoplantaris Pustulosis

A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.


Heteroantibodies
Antibodies, Heterophile
Heterophile Antibodies
Heterogenetic Antibodies
Antibodies, Heterologous
Antibodies, Heterotypic
Antibodies, Xenogeneic
H-D Antibodies
Antibodies, Heterophil
Paul-Bunnell Antibodies
Forssman Antibody
Xenoantibodies
Hanganutziu-Deicher Antibodies
Heterologous Antibodies
P-B Antibodies
Antibodies, Xenogenic
Antibodies, Heterogenetic

Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.


DIMS (Disorders of Initiating and Maintaining Sleep)

Sleep Initiation and Maintenance Disorders

Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.


Posterior Fossa Tumors
Benign Infratentorial Neoplasms
Infratentorial Tumors
Malignant Infratentorial Neoplasms
Infratentorial Neoplasms, Benign
Infratentorial Neoplasms, Malignant
Neoplasms, Posterior Fossa
Infratentorial Neoplasms
Neoplasms, Infratentorial
Posterior Fossa Neoplasms
Infratentorial Cancer

Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).


Shop, Hospital
Shop, Hospital Gift
Shops, Hospital Gift
Hospital Shop
Hospital Shops
Gift Shop, Hospital
Gift Shops, Hospital
Hospital Gift Shops
Shops, Hospital
Hospital Gift Shop

Stores located in hospitals selling merchandise or services for the convenience of patients, staff, and visitors.


Gastric Per-oral Endoscopic Pyloromyotomy

Gastric Peroral Endoscopic Pyloromyotomy

Surgical incision of the PYLORUS used to treat pyloric stenoses (e.g. INFANTILE HYPERTROPHIC PYLORIC STENOSIS).


Optical Process
Optical Concepts
Optical Processes
Optical Phenomenon
Optical Phenomena

LIGHT, its processes and properties, and the characteristics of materials interacting with it.


Binding Motifs, Protein Interaction
Protein Interaction Domains
Protein Interaction Binding Motifs
Protein Interaction Motifs
Protein-Protein Interaction Domains
Protein Interaction Domains and Motifs

Short AMINO ACID SEQUENCES which are the BINDING SITES on the LIGANDS of protein interaction domains.


Albalon
All Clear
Proculin
Siozwo
Naphcon Forte
Clear Eyes
Nafazair
Naphcon
VasoNit
Vasoclear
Tele-Stulln
Vasocon Regular
Privin
Afazol Grin
Naphazoline Monohydrochloride
Colirio Alfa
Miraclar
Optazine
Privine
Naphazoline Hydrochloride
Idril
Naphazoline
Vasoconstrictor Pensa
Vasocon
AK-Con
Naphazoline Nitrate

An adrenergic vasoconstrictor agent used as a decongestant.


Valeranes
Eremophilanes
Caryophyllane Derivatives
Polycyclic Sesquiterpenes
Valerane Derivatives
Caryophyllanes
Eremophilane Derivatives

Sesquiterpenes that contain two or more ring structures


Lacunar Dementia
Multi-Infarct Dementia
Dementia, Multi-Infarct
Dementia, Multiinfarct
Lacunar Dementias
Dementia Multi-Infarct

Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)


Black Plague
Pneumonic Plague
Meningeal Plague
Plague
Yersinia pestis Infection
Bubonic Plague
Septicemic Plague
Pulmonic Plague
Black Death

An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.


Pravastatin Monosodium Salt, (6 beta)-Isomer

An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).


Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.


A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA.


Object Attachment
Bonding (Psychology)
Bonds, Emotional
Psychological Bonding
Object Relations
Object Relationship
Emotional Bonds
Bonding, Psychological
Symbiotic Relations (Psychology)

Emotional attachment to someone or something in the environment.


Chamois
Rupicapra
Rupicapra rupicapra
Rupicapra pyrenaica
Chamois, Pyrenean

Species of chamois found in the Pyrenees of northwestern Spain and the Apennines of central Italy.


Asherman's Syndrome
Uterine Synechiae
Intrauterine Synechiae
Gynatresia
Asherman Syndrome

A condition with obliterated endometrial cavity causing secondary AMENORRHEA.


Hyoscine
Scopolamine
Scopolamine Hydrobromide
Isopto Hyoscine
Boro-Scopol
Travacalm HO
Scopace
Scopolamine Cooper
Scopoderm TTS
Kwells
Transderm Scop
Transderm-V
Vorigeno
Scoburen

An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Its many uses include an anesthetic premedication, the treatment of URINARY INCONTINENCE and MOTION SICKNESS, an antispasmodic, and a mydriatic and cycloplegic.


Thermal Plasma
Cold Plasma
Plasma Gases
Non-Thermal Atmospheric Pressure Plasma

Ionized gases, consisting of free electrons and ionized atoms or molecules which collectively behave differently than gas, solid, or liquid. Plasma gases are used in biomedical fields in surface modification; biological decontamination; dentistry (e.g., PLASMA ARC DENTAL CURING LIGHTS); and in other treatments (e.g., ARGON PLASMA COAGULATION).


BEK Fibroblast Growth Factor Receptor Kinase

Bek-Related Fibroblast Growth Factor-Receptor-1

Receptor, Fibroblast Growth Factor, Type 2

An isoform of fibroblast growth factor receptor 2 found mainly in EPITHELIAL CELLS that is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10.


Sodium Channel Protein Type 11 Subunit alpha

Voltage-Gated Sodium Channel Type 11 Subunit alpha

A voltage-gated sodium channel subtype found in the neurons of the NERVOUS SYSTEM and DORSAL ROOT GANGLIA. It may play a role in the generation of heat and mechanical pain hypersensitivity.


Prairie Dogs
Spermophilus
Sciuridae
Citellus
Eutamias
Susliks
Tamias
Chipmunks
Squirrels

A family of the order Rodentia which contains 49 genera. Some of the more common genera are MARMOTA, which includes the marmot and woodchuck; Sciurus, the gray squirrel, S. carolinensis, and the fox squirrel, S. niger; Tamias, the eastern and western chipmunk; and Tamiasciurus, the red squirrel. The flying squirrels, except the scaly-tailed Anomaluridae, also belong to this family.


Receptor-Interacting Protein Serine-Threonine Kinases

Receptor-Interacting Protein Serine-Threonine Kinase 3

Receptor-Interacting Protein Serine-Threonine Kinase 1

A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.


Bone Tissue
Bones and Bone
Bone and Bones
Bone
Bony Apophysis
Bones and Bone Tissue
Bony Apophyses
Bones
Condyle

A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.


Estradiol Hemihydrate, (17 alpha)-Isomer

Estradiol, (8 alpha,17 beta)-(+-)-Isomer

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.


Procollagen Type II
Collagen Type II, alpha1 Chain
Collagen Type II
Collagen Type II, alpha1 Subunit
Collagen alpha1(II)
Type II Procollagen
Type II Collagen

A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.


A phenylalanine and cyclohexane derivative that acts as a hypoglycemic agent by stimulating the release of insulin from the pancreas. It is used in the treatment of TYPE 2 DIABETES.


Carcinoma, Cribriform
Adenocarcinoma, Basal Cell
Adenocarcinoma, Oxyphilic
Carcinoma, Granular Cell
Adenocarcinoma
Adenocarcinoma, Granular Cell
Adenocarcinoma, Tubular
Carcinoma, Tubular
Adenoma, Malignant

A malignant epithelial tumor with a glandular organization.


Maternal Patterns of Care
Maternal Care Patterns
Maternal Behavior

The behavior patterns associated with or characteristic of a mother.


Migraine with Aura
Complicated Migraine
Basilar-Type Migraine
Hemiplegic-Ophthalmoplegic Migraine
Classical Migraine
Acute Onset Aura Migraine
Migraine with Prolonged Aura
Basilar Artery Migraine
Migraine, Prolonged Aura
Basilar Migraine
Typical Aura without Headache
Migraine, Classic
Familial Hemiplegic Migraine
Migraine with Typical Aura
Classic Migraine
Migraine Aura without Headache
Hemiplegic Migraine, Familial
Migraine with Acute Onset Aura

A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)


Trolox Equivalence Antioxidant Capacity Assay

A measure of the ability of a substance, such as a food, to quench oxygen free radicals in vitro.


Eunuchism
Eunuchoidism
Hypogonadism, Male

Eunuch-like state in which the male individual has non-functional TESTES.


Ectopic Pupil
Pupil Malformations
Pupillary Anomaly
Keyhole Pupil
Afferent Pupillary Defect
Pupillary Functions, Abnormal
Non-Syphilitic Argyll-Robertson Pupil
Pupillary Paralysis
Pupillary Occlusion
Deformed Pupil
Marcus-Gunn Pupil
Pupil Reaction Absent
Pupillary Sector Paralysis
Wernicke Hemianopic Pupil
Pupillary Disorders
Occluded Pupils
Fixed Pupils
Sector Pupil Palsy
Wernicke's Hemianopic Pupil
Pupillary Sphincter Rupture
Pupil Disorders
Efferent Pupillary Defect

Conditions in which the pupil does not react normally to dilation and constriction. Signs of pupillary abnormalities originate from the pupil's shape, position, and response to stimulation.


FSH-Secreting Cells
Gonadotrophs
LH-Secreting Cells
FSH-Producing Cells
FSH Cells
LH-Producing Cells
LH Cells

Anterior pituitary cells that can produce both FOLLICLE STIMULATING HORMONE and LUTEINIZING HORMONE.


Ataxia, Cerebellar
Cerebellar Incoordination
Hypermetria
Cerebellar Ataxia
Dysmetria
Adiadochokinesis
Cerebellar Dysmetria
Cerebellar Hemiataxia

Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)


Nomifensin
Nomifensine Maleate (1:1)
Merital
Hoe-984
Linamiphen
Nomifensine
Nomifensine Maleate

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)


Antispasmodic Drugs
Spasmolytics
Parasympatholytics
Parasympathetic-Blocking Agents
Antispasmodic Effect
Parasympatholytic Drugs
Antispasmodic Agents
Antispasmodic Effects
Antispasmodics
Parasympatholytic Agents
Parasympatholytic Effect
Parasympatholytic Effects

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.


Drug Misuse
Nonprescription Drug Misuse
Non-Prescription Drug Misuse
Over-the-Counter Drug Misuse
Non-Prescription Medicine Misuse

Use of a drug for a purpose not consistent with legal or medical guidelines.


Orthotic Tape
Kinesiotape
Kinesio Tape
Athletic Tape

Adhesive tape with the mechanical strength to resist stretching. It is applied to the skin to support, stabilize, and restrict movement to aid healing and/or prevent injuries of the MUSCULOSKELETAL SYSTEM.


Homer Proteins
Homer 1C
Homer 1a
Homer 3
Homer 2 Proteins
Homer 1
Homer Scaffolding Proteins
Homer 3 Proteins
Homer 1C Proteins
Homer 1 Proteins
Homer 2

Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.


Sympatholytics
Sympatholytic Effect
Sympatholytic Effects
Sympatholytic Agents
Sympathetic-Blocking Agents
Sympatholytic Drugs

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.


Bereitschaftspotential
Contingent Negative Variation
Readiness Potential

A negative shift of the cortical electrical potentials that increases over time. It is associated with an anticipated response to an expected stimulus and is an electrical event indicative of a state of readiness or expectancy.


The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.


Inflammatory Linear Verrucous Epidermal Naevus

Inflammatory Linear Verrucose Epidermal Nevus

A syndrome characterized by lesions occurring on the face, scalp, or neck which consist of congenital hypoplastic malformations of cutaneous structures and which over time undergo verrucous hyperplasia. Additionally it is associated with neurological symptoms and skeletal, ophthalmological, urogenital, and cardiovascular abnormalities.


Topical Eutectic-Like Mixture for Premature Ejaculation

A topical local anesthetic preparation that is composed of a mixture of lidocaine and prilocaine. It is used to provide anesthesia during minor surgery and for the treatment of PREMATURE EJACULATION.


Non-linear Models
Non-linear Dynamics
Nonlinear Dynamics
Models, Nonlinear
Chaos Theory

The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.


ZD4522
Rosuvastatin Calcium
Rosuvastatin
ZD 4522
Crestor

A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.


Hyperaldosteronism
Aldosteronism
Primary Hyperaldosteronism
Conn's Syndrome
Conn Syndrome

Primary hyperaldosteronism caused by the excess production of ALDOSTERONE by an ADENOMA of the ZONA GLOMERULOSA or CONN ADENOMA.


Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.


A family in the suborder Caniformia, Order CARNIVORA, comprised of one genus Ailurus, the lesser pandas.


Azlin
Bay-e 6905
Sodium Azlocillin
Azlocillin
Securopen
Azlocillin Sodium

A semisynthetic ampicillin-derived acylureido penicillin.


Dys-symbiosis Dysbiosis Disbacteriosis Disbiosis Dysbacteriosis

Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.


RNA, Ribosomal, Precursors
rRNA Precursor
Pre-tRNA
snRNA Precursor
RNA Precursor
tRNA Precursor
RNA, Transfer, Precursors
RNA, Messenger, Precursors
Precursor RNA
Primary Transcript, RNA
Pre-rRNA
RNA, Small Nuclear, Precursors
RNA Precursors
mRNA Precursor
Pre-mRNA
Primary RNA Transcript
Pre-snRNA

The product of RNA polymerase prior to any post-transcriptional modifications (RNA PROCESSING, POST-TRANSCRIPTIONAL), i.e. RNA copies from DNA that exactly represent the genome sequence.


Urinorm
Desuric
Benzbromaron
Benzbromarone
Narcaricin
Benzbromaron AL
Benzbromaron-Ratiopharm
Acifugan
Besuric

Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.


Androgenic Compounds
Androgenic Agents
Androgen Effects
Androgen Effect
Androgens
Androgen Receptor Agonists

Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.


Aminopeptidase M
Aminopeptidase N
CD13 Antigen
Aminooligopeptidase
CD13 Antigens
Alanyl Aminopeptidase
Membrane Alanyl Aminopeptidase
Amino-oligopeptidase
Antigens, CD13
Alanine Aminopeptidase


Spouses
Spousal Notification
Wife
Married Persons
Husbands
Domestic Partners
Wives
Spouse

Married persons, i.e., husbands and wives, or partners. Domestic partners, or spousal equivalents, are two adults who have chosen to share their lives in an intimate and committed relationship, reside together, and share a mutual obligation of support for the basic necessities of life.


CY-216
Nadroparin Calcium
Nadroparin
Nadroparine
Fraxiparin
Fraxiparine
LMF CY-216
CY 216

A heparin fraction with a mean molecular weight of 4500 daltons. It is isolated from porcine mucosal heparin and used as an antithrombotic agent. (From Merck Index, 11th ed)


Tripterygium wilfordii
Tripterygium
Tripterygium hypoglaucum
Leigong Teng
Thundergod Vine

A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.


Akt-alpha Protein
c-akt Proto-Oncogene Protein
Rac Protein Kinase
Protein Kinase B
akt Proto-Oncogene Protein
Akt-beta Protein
Akt-gamma Protein
Proto-Oncogene Proteins c-akt
Rac-PK alpha Protein
Protein Kinase B alpha
RAC-PK Protein
Proto-Oncogene Proteins c-akt1
AKT1 Protein Kinase
Proto-Oncogene Proteins c-akt3
Protein Kinase B beta
Proto-Oncogene Protein RAC
Rac-PK beta Protein
Related to A and C-Protein
Proto-Oncogene Proteins c-akt2
AKT3 Protein Kinase
Protein-Serine-Threonine Kinase (Rac)
c-akt Protein
Proto-Oncogene Protein Akt
Protein Kinase B gamma
AKT2 Protein Kinase

Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.


Examination, Oral
Oral Examination
Oral Diagnosis
Diagnosis, Oral

Examination of the mouth and teeth toward the identification and diagnosis of intraoral disease or manifestation of non-oral conditions.


Molecular Genetics
Genetics, Biochemical
Genetics, Molecular
Molecular Biology
Biology, Molecular
Biochemical Genetics

A branch of genetics which deals with the chemical structure of the genes and with the mechanisms by which the genes control and regulate the structure and synthesis of proteins.


Sulfanilamide Magnesium Salt
Sulfanilamide
Sulfanilamide Strontium Salt
Sulfanilamide Barium Salt
Azol Polvo
Sulfanilamide Hydrochloride
Sulfanilamide Sodium Salt
Sulfanilamide Lithium Salt
Sulphanilamide
Sulfanilamide Sodium
Sulfanilamide Monohydrate
Sulfanilamide Silver Salt
Sulfanilamide Zinc Salt
4-aminobenzenesulfonamide
Sulfanilamide Cadmium Salt

A short-acting sulfonamide used as an anti-infective agent. It has lower anti-bacterial activity than SULFAMETHOXAZOLE.


Basal Ganglia Vascular Disease
Lenticulostriate Vascular Diseases
Vascular Diseases, Lenticulostriate
Cerebrovascular Disease, Basal Ganglia
Vascular Diseases, Basal Ganglia
Lenticulostriate Vasculopathy
Lenticulostriate Diseases, Vascular
Basal Ganglia Cerebrovascular Disease
Vascular Disease, Basal Ganglia

A pathological condition caused by impaired blood flow in the basal regions of cerebral hemispheres (BASAL GANGLIA), such as INFARCTION; HEMORRHAGE; or ISCHEMIA in vessels of this brain region including the lateral lenticulostriate arteries. Primary clinical manifestations include involuntary movements (DYSKINESIAS) and muscle weakness (HEMIPARESIS).


Lobular Carcinoma In Situ
Breast Carcinoma In Situ
LCIS, Lobular Carcinoma In Situ

A condition in which abnormal cells have not spread outside the duct, lobule, or nipple to other tissues of the breast. There are 3 types of breast carcinoma in situ: DUCTAL CARCINOMA IN SITU; LOBULAR CARCINOMA IN SITU; and PAGET DISEASE OF THE NIPPLE.


Leukocyte Differentiation Antigens, Human

Differentiation Antigens, Leukocyte, Human

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.


A plant genus of the family SAPOTACEAE. Members contain triterpenes. Some species in this genus are called mamey which is also a common name for MAMMEA.


Drying Agents
Humectants
Hygroscopic Agents
Desiccants

Materials that readily absorb moisture from their surroundings.


Alcuronium Dichloride
N,N'-Diallylnortoxiferinium Dichloride
Diallylnortoxiferine
Alcuronium Chloride
Dialferine
Alloferin
Alcuronium
Allnortoxiferine

A non-depolarizing skeletal muscle relaxant similar to TUBOCURARINE. It is used as an anesthesia adjuvant.


Facial Palsy, Lower Motor Neuron
Facial Palsy, Upper Motor Neuron
Facial Paralysis, Central
Facial Paralysis, Peripheral
Facial Paralysis
Hemifacial Paralysis
Lower Motor Neuron Facial Palsy
Facial Paresis
Upper Motor Neuron Facial Palsy
Facial Palsy

Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.


Cancer of Sigmoid
Sigmoidal Cancer
Sigmoid Neoplasms
Neoplasms, Sigmoid
Sigmoid Colon Cancer
Sigmoid Colon Neoplasms
Sigmoid Cancer
Cancer of the Sigmoid


Healthcare Quality Assurance
Healthcare Quality Assessment
Quality Assessment, Healthcare
Quality Assurance, Healthcare
Health Care Quality Assessment
Quality Assurance, Health Care
Health Care Quality Assurance
Quality Assessment, Health Care

Activities and programs intended to assure or improve the quality of care in either a defined medical setting or a program. The concept includes the assessment or evaluation of the quality of care; identification of problems or shortcomings in the delivery of care; designing activities to overcome these deficiencies; and follow-up monitoring to ensure effectiveness of corrective steps.


Calcium Channel Agonists
Calcium Channel Activators
Calcium Channel Agonist
Calcium Channel Agonists, Exogenous
Exogenous Calcium Channel Agonists

Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.


Evaluation Studies, FDA Phase III as Topic

Evaluation Studies, FDA Phase 3 as Topic

Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.


A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)


Pelvic Pouches
Kock Pouch
Ileal Pouches
Ileal Reservoirs
Ileoanal Pouches
Ileoanal Reservoirs
J-Pouch
W-Pouch
Colonic Pouches
S-Pouch

Sacs or reservoirs created to function in place of the COLON and/or RECTUM in patients who have undergone restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).


Healthcare Fraud
Fraud
Drug Counterfeiting
Health Care Fraud
Fraud, Health Care
Kickbacks

Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.


Provirus Integration
Virus Integration
Integration, Virus
Viral integration
Integration, Provirus

Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.


Inter-Observer Variation
Intraobserver Variability
Observer Variation
Intraobserver Variation
Observer Bias
Bias, Observer
Interobserver Variation
Inter-Observer Variability
Interobserver Variability
Intra-Observer Variation
Intra-Observer Variability

The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).


Eucoprost Proscar Chibro-Proscar Propecia Propeshia MK-906 Finasteride

An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.


Vas Deferens Reanastomosis
Fallopian Tube Reanastomosis
Sterilization Reversal
Tubal Reanastomosis
Vas Reanastomosis

Procedures to reverse the effect of REPRODUCTIVE STERILIZATION and to regain fertility. Reversal procedures include those used to restore the flow in the FALLOPIAN TUBE or the VAS DEFERENS.


H-102-09
Zimelidin
Zelmid
Zimeldine Hydrochloride
Zimeldine
Zimelidine
Zimelidine Hydrochloride

One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)


Plant Microspores
Microspores, Plant
Pollen Grains
Male Gametophytes
Male Gametes, Plant
Pollen

The fertilizing element of plants that contains the male GAMETOPHYTES.


Receptors, 5-Hydroxytryptamine
5-HT Receptors
Serotonin Receptors
Tryptamine Receptors
Receptors, Tryptamine
Receptors, Serotonin
5-Hydroxytryptamine Receptors
Receptors, 5-HT

Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.


Peritoneal Carcinomatosis
Peritoneal Neoplasms
Peritoneal Surface Malignancy


Shaker Superfamily of Potassium Channels

Voltage-gated potassium channels whose primary subunits contain six transmembrane segments and form tetramers to create a pore with a voltage sensor. They are related to their founding member, shaker protein, Drosophila.


3-Phosphoinositide Dependent Protein Kinase-1

3-Phosphoinositide-Dependent Kinase 1 (PDK1)

3-Phosphoinositide Dependent Protein Kinase-2

Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).


Mutism
Mutism, Selective
Mutism, Organic
Selective Mutism
Mutism, Elective
Kussmaul's Aphasia
Mutism, Conversion
Kussmaul Aphasia
Mutism, Voluntary

The inability to generate oral-verbal expression, despite normal comprehension of speech. This may be associated with BRAIN DISEASES or MENTAL DISORDERS. Organic mutism may be associated with damage to the FRONTAL LOBE; BRAIN STEM; THALAMUS; and CEREBELLUM. Selective mutism is a psychological condition that usually affects children characterized by continuous refusal to speak in social situations by a child who is able and willing to speak to selected persons. Kussmal aphasia refers to mutism in psychosis. (From Fortschr Neurol Psychiatr 1994; 62(9):337-44)


Diffuse Parenchymal Lung Diseases
Lung Diseases, Interstitial
Interstitial Lung Diseases
Pneumonia, Interstitial
Pneumonitis, Interstitial

A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.


Rays (Fish)
Skates (Fish)
Raja
Rajiformes
Rays, Fish
Rajidae
Skates, Fish

Rays is the common name for the order Rajiformes, which consists of rays and skates. However, there are rays in other orders as well, such as the electric ray (TORPEDO).


Ankyrin Repeat Domains
ANK Repeat
Ankyrin-Like Repeats
ANK Repeat Domains
Ankyrin Repeats
Ankyrin Repeat

Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33-amino acids was discovered in ANKYRIN where it is involved in interaction with the anion exchanger (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE). Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via protein-protein interactions.


Abdominoperineal Resection
Abdomino-Perineal Rectum Excision
Abdominoperineal Rectum Excision
Abdomino-Perineal Resection
Rectum Excision
Rectum Resection
Proctectomy
Abdominoperineal Excision
Abdomino-perineal Excision


Nordiazepam
Ro 5-2180
Demethyldiazepam
Nordazepam
Nordaz
Tranxilium N
Vegesan
Desmethyldiazepam
Norprazepam
N-Desalkylhalazepam
Dealkylprazepam
Deoxydemoxepam
N-Destrifluoroethylhalazepam
N-Descyclopropylmethyl-Prazepam
Calmday
N-Descyclopropylmethylprazepam

An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.


Mycobacterium bovis
Calmette-Guerin Bacillus
BCG

The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.


Industrial Respirators
Respiratory Protective Devices
Respirators, Industrial
Respirators, Air-Purifying
Gas Masks

Respirators to protect individuals from breathing air contaminated with harmful dusts, fogs, fumes, mists, gases, smokes, sprays, or vapors.


Buses
Trucks
Motor Vehicles
Tanks
Armored Vehicles

AUTOMOBILES, trucks, buses, or similar engine-driven conveyances. (From Random House Unabridged Dictionary, 2d ed)


Amine Oxidase, Copper-Containing
Amine Oxidase (Copper-Containing)
Diaminobenzidine Oxidase
Copper Amine Oxidase
Semicarbazide-Sensitive Amine Oxidase
Histaminase
Xylylene Diamine Oxidase
Diamine Oxidase

A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.


Crassostrea gigas
Oysters, Eastern
Oyster, Eastern
Crassostrea
Crassostrea virginica

A genus of oysters in the family OSTREIDAE, class BIVALVIA.


A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.


Cohort Studies
Studies, Closed Cohort
Studies, Concurrent
Incidence Studies
Historical Cohort Studies
Analysis, Cohort
Cohort Analysis
Closed Cohort Studies
Concurrent Studies
Cohort Studies, Closed
Cohort Studies, Historical
Studies, Historical Cohort

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.


Breast Milk Expression
Breast Pumping
Breastmilk Collection
Breast Milk Collection
Breastmilk Expression

The act of evacuating BREAST MILK by hand or with a pump.


Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.


Liberty
Freedom
Right to Movement
Libertarianism
Religious Freedom
Freedom of Religion

Right to freedom of movement, right to move freely.


Paclitaxel, (4 alpha)-Isomer
Paclitaxel
Anzatax
NSC-125973
Paxene
Bris Taxol
Taxol
Taxol A
Praxel
7-epi-Taxol
Onxol

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.


Blood Substitutes
Hemoglobin Substitutes
Erythrocyte Substitutes
Blood, Artificial
Red Cell Substitutes
Artificial Blood
Artificial Hemoglobin
Artificial Erythrocytes

Chemically-engineered hemoglobin-based oxygen carriers or ARTIFICIAL HEMOGLOBIN oxygen carriers. They may or may not be encapsulated by ARTIFICIAL MEMBRANES.


N-POMC
gamma1-MSH
gamma-Melanotropin Precursor
MSH, gamma
gamma-Melanocyte-Stimulating Hormone
gamma-MSH
Melanocyte-Stimulating Hormone, gamma
gamma3-MSH
gamma2-MSH
gamma-Melanotropin
N-Terminal Peptide of POMC (NPP)
Pro-gamma-MSH
Pro-gamma-Melanotropin

The 11-residue peptide that is fully amidated.


Fasciculoventricular Pathway
Accessory Conducting Pathway
Accessory Atrioventricular Pathways
Bundle of Kent
Accessory Atrioventricular Bundle
Mahaim Fibers
Atrio-Hisian Bypass Tract
Accessory Conducting Pathways
Atriohisian Fibers
Kent Bundle
James Fibers
Nodoventricular Pathway
Concealed Accessory Pathway
Atriohisian Tract
Fasciculoventricular Accessory Pathway
Accessory Atrioventricular Pathway
Nodoventricular Accessory Pathway

Extra impulse-conducting tissue in the heart that creates abnormal impulse-conducting connections between HEART ATRIA and HEART VENTRICLES.


Octanoates
Caprylates
Octanoic Acids
Caprylic Acids

Derivatives of caprylic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure.


Axoplasmic Flow
Axoplasmic Streaming
Axonal Transport
Axoplasmic Transport

The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)


Bovine Papillomavirus 2
BVP-2
BVP-1
Bovine Papillomavirus Type 2
Bovine Papillomavirus Type 1
Bovine papillomavirus 1

A species of DELTAPAPILLOMAVIRUS infecting cattle.


Type 1 Autoimmune Pancreatitis
IgG4-related Pancreatitis
Idiopathic Duct-centric Pancreatitis
Type 2 Autoimmune Pancreatitis
Autoimmune Pancreatitis
Type 1 AIP
Type 2 AIP

Chronic pancreatitis associated with autoimmune diseases.


Leucocidin
Leukocidin
Leukocidins
Leukocidin Proteins

Pore forming proteins originally discovered for toxic activity to LEUKOCYTES. They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms.


Dyspraxia of Gait
Gait Apraxia
Bruns' Apraxia of Gait
Frontal Gait Apraxia
Bruns' Gait Apraxia
Apraxia of Gait

Impaired ambulation not attributed to sensory impairment or motor weakness. FRONTAL LOBE disorders; BASAL GANGLIA DISEASES (e.g., PARKINSONIAN DISORDERS); DEMENTIA, MULTI-INFARCT; ALZHEIMER DISEASE; and other conditions may be associated with gait apraxia.


Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt)

A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.


Tooth Agenesis, Selective, 1
Hypodontia
Hypodontia Oligodontia 1
Tooth Agenesis, Familial
Anodontia

Congenital absence of the teeth; it may involve all (total anodontia) or only some of the teeth (partial anodontia, hypodontia), and both the deciduous and the permanent dentition, or only teeth of the permanent dentition. (Dorland, 27th ed)


Macrocephaly, Pseudopapilledema, and Multiple Hemangiomata

Macrocephaly, Multiple Lipomas, and Hemangiomata

Dysplastic Gangliocytoma of the Cerebellum

Macrocephaly, Pseudopapilledema, and Multiple Hemangiomas

A hereditary disease characterized by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Facial trichilemmomas and papillomatous papules of the oral mucosa are the most characteristic lesions. Individuals with this syndrome have a high risk of BREAST CANCER; THYROID CANCER; and ENDOMETRIAL CANCER. This syndrome is associated with mutations in the gene for PTEN PHOSPHATASE.


Mobile Apps
Portable Software Applications
Portable Electronic Applications
Portable Electronic Apps
Portable Software Apps
Mobile Applications

Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.


Heat Avoidance
Thermal Avoidance
Galvanotaxis
Thermotaxis
Compass Orientation
Taxis Response
Tropotaxis

A behavior in free-moving organism that results in motion or orientation toward or away from an external stimulus.


Mephitidae
Mephitis
Conepatus
Striped Skunks
Skunks
Spotted Skunks
Hog-nosed Skunks
Hooded Skunks
Spilogalae

The family of omnivorous New World skunks, showing typical warning coloration of patterned black and white and able to eject a malodorous secretion when the animal is startled or in danger.


Hereditary Familial Congenital Hemorrhagic Nephritis

A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.


Heart Failure, Left-Sided
Congestive Heart Failure
Cardiac Failure
Left-Sided Heart Failure
Heart Failure
Myocardial Failure
Heart Decompensation
Heart Failure, Right-Sided
Right-Sided Heart Failure
Heart Failure, Congestive

Heart failure involving the RIGHT VENTRICLE.


PAR101
Lipiarmycin B4
Fidaxomicin
PAR-101
Lipiarmycin B3
Lipiarmycin B
Lipiarmycin
Lipiarmycin A4
Tiacumicin C
Tiacumicin B
PAR 101
Lipiarmycin A3

A narrow-spectrum macrolide antibacterial agent that is used in the treatment of diarrhea associated with CLOSTRIDIUM DIFFICILE INFECTION.


Dental Physiological Concepts
Dental Physiological Phenomena
Dental Physiological Processes
Dental Physiology
Physiology, Dental
Dental Physiological Phenomenon
Dental Physiological Process

Physiological processes and properties of the DENTITION.


RNA 5' Terminal Oligopyrimidine Regulatory Sequence

RNA 5' Terminal Oligopyrimidine Sequence

A regulatory sequence found in the 5' terminal regions of a variety of RNA species. The sequence starts with a CYTIDINE, which is followed by a stretch of 5 to 15 PYRIMIDINE NUCLEOTIDES. Messenger RNA that contains the 5' Terminal Oligo Pyrimidine tract is often referred to as 5' TOP mRNA. The sequence acts as a translational regulator and has been found in mRNAs for PEPTIDE ELONGATION FACTORS and RIBOSOMAL PROTEINS.


Referred Facial Pain
Facial Pain, Referred
Referred Pain
Pain, Referred

A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear.


Clam, Softshell
Mya
Mya arenaria
Clams, Softshell

A genus of soft-shell clams in the family Myidae, class BIVALVIA.


Synovial Hypertrophy
Synovitis
Plica Syndrome
Synovial Thickening
Synovial Plica Syndrome


Vaginal Suppositories
Vaginal Suppository
Suppositories
Rectal Suppositories

Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.


Dental Radiovisiography
Digora
Digital Dental Radiography, Direct
Visualix
Dental Digital Radiography
Scanora
Sens-A-Ray
Radiography, Dental, Digital
Digital Radiography, Dental
Radiovisiography, Dental

A rapid, low-dose, digital imaging system using a small intraoral sensor instead of radiographic film, an intensifying screen, and a charge-coupled device. It presents the possibility of reduced patient exposure and minimal distortion, although resolution and latitude are inferior to standard dental radiography. A receiver is placed in the mouth, routing signals to a computer which images the signals on a screen or in print. It includes digitizing from x-ray film or any other detector. (From MEDLINE abstracts; personal communication from Dr. Charles Berthold, NIDR)


Foot Orthosis
Foot Orthotic Devices
Orthotic Shoe Inserts
Orthotic Insoles
Foot Orthoses
Foot Arch Supports

Devices used to support or align the foot structure, or to prevent or correct foot deformities.


Snub-Nosed Monkeys
Simias concolor
Asian Colobines
Semnopithecus
Lutungs
Langurs
Simias
Simakobu
Douc Langurs
Nasalis
Pygathrix
Indian Langurs
Presbytini
Proboscis Monkey
Rhinopithecus
Trachypithecus
Presbytis
Douc Monkeys

The tribe of subfamily COLOBINAE, family CERCOPITHECIDAE. They are found in India, Indonesia, Malaysia, and Thailand.


Cerebrospinal Fluid Drainage, Spontaneous

Spinal Cerebrospinal Fluid Leak, Post-Traumatic

Cerebrospinal Fluid Drainage, Post-Traumatic

Spinal Cerebrospinal Fluid Leak, Spontaneous

Spinal Cerebrospinal Fluid Leak, Traumatic

Cerebrospinal Fluid Leakage, Spontaneous

Cerebrospinal Fluid Leakage, Post-Traumatic

Discharge of cerebrospinal fluid through a hole through the skull bone most commonly draining from the nose (CEREBROSPINAL FLUID RHINORRHEA) or the ear (CEREBROSPINAL FLUID OTORRHEA).


Excitatory Amino Acid Effects
Agents, Excitatory Amino Acid
Glutamate Agents
Excitatory Amino Acid Effect
EAA Agents
Glutamatergic Agents
Amino Acid Agents, Excitatory
Excitatory Amino Acid Agents
Amino Acids, Excitatory, Agents

Drugs used for their actions on any aspect of excitatory amino acid neurotransmitter systems. Included are drugs that act on excitatory amino acid receptors, affect the life cycle of excitatory amino acid transmitters, or affect the survival of neurons using excitatory amino acids.


Rauwolfia serpentina
Rauvolfia
Rauvolfia serpentina
Rauwolfia

A plant genus of the APOCYNACEAE or dogbane family. Alkaloids from plants in this genus have been used as tranquilizers and antihypertensive agents. RESERPINE is derived from R. serpentina.


Structure Activity Relationship, Quantitative

Quantitative Structure Property Relationship

A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.


Medicine, Chinese Traditional
Chung I Hsueh
Chinese Traditional Medicine
Chinese Medicine, Traditional
Traditional Chinese Medicine
Traditional Tongue Diagnosis
Zhong Yi Xue
Traditional Tongue Assessment
Traditional Medicine, Chinese

A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.


Cretinism
Endemic Cretinism
Myxedema, Congenital
Fetal Iodine Deficiency Disorder
Congenital Hypothyroidism

A condition in infancy or early childhood due to an in-utero deficiency of THYROID HORMONES that can be caused by genetic or environmental factors, such as thyroid dysgenesis or HYPOTHYROIDISM in infants of mothers treated with THIOURACIL during pregnancy. Endemic cretinism is the result of iodine deficiency. Clinical symptoms include severe MENTAL RETARDATION, impaired skeletal development, short stature, and MYXEDEMA.


Cussonia
Schefflera
Araliaceae
Umbrella Tree
Polyscias

A plant genus of the family ARALIACEAE that contains cussonosides or sieboldianosides (oleanane saponins).


Chorangioma
Angioma
Hemangioma, Histiocytoid
Chorioangioma
Hemangioma, Intramuscular
Hemangioma

A vascular anomaly due to proliferation of blood or lymphatic vessels that forms a tumor-like mass. Vessels in the angioma may or may not be dilated.


Rhinolophus
Horseshoe Bats
Chiroptera
Pteropus
Flying Foxes
Rousettus
Pteropodidae
Bats

Genus in the subfamily Rhinolophinae comprising the horseshoe bats. The natural reservoir of the SARS VIRUS is Rhinolophus sinicus.


Status Epilepticus, Generalized Convulsive

Generalized Convulsive Status Epilepticus

A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)


Rogitine
Phentolamine Mono-hydrochloride
Regitine
Phentolamine Mesilate
Z-Max
Phentolamine Mesylate
Regityn
Phentolamine
Phentolamine Methanesulfonate
Fentolamin

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.


Campath-1M
Campath-1-G
Lemtrada
Monoclonal Antibody Campath-1H
Campath-1H
Campath
Campath-1G
Campath 1M
Alemtuzumab
Campath 1G
Campath 1H
MabCambath

An anti-CD52 ANTIGEN monoclonal antibody used for the treatment of certain types of CD52-positive lymphomas (e.g., CHRONIC LYMPHOCYTIC LEUKEMIA; CUTANEOUS T-CELL LYMPHOMA; and T-CELL LYMPHOMA). Its mode of actions include ANTIBODY-DEPENDENT CELL CYTOTOXICITY.


Cl2 Gas
Chlorine
Chlorine-35
Chlorine Gas

A greenish-yellow, diatomic gas formed by chlorine (Cl2) that is a powerful irritant and causes fatal pulmonary edema.


A-Type Potassium Channel Modulatory Protein 2

A-Type Potassium Channel Modulatory Protein 1

A-Type Potassium Channel Modulatory Protein 3

A-Type Potassium Channel Modulatory Proteins

A-Type Potassium Channel Modulatory Protein 4

Downstream Regulatory Element Antagonist Modulator

Type A Potassium Channel Interacting Proteins

A family of neuronal calcium-sensor proteins that interact with and regulate potassium channels, type A.


Marker, Tumor Metabolite
Markers, Neoplasm Metabolite
Marker, Biological Tumor
Tumor Metabolite Marker
Tumor Markers, Biochemical
Carcinogen Markers
Biomarkers, Cancer
Biomarkers, Tumor
Markers, Tumor Metabolite
Biological Tumor Markers
Biochemical Tumor Markers
Tumor Markers, Biological
Marker, Neoplasm Metabolite
Biological Tumor Marker
Metabolite Markers, Tumor
Neoplasm Metabolite Markers
Markers, Tumor
Metabolite Markers, Neoplasm
Tumor Markers, Biologic
Marker, Biologic Tumor
Marker, Biochemical Tumor
Markers, Biological Tumor
Markers, Biochemical Tumor

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or BODY FLUIDS. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including HORMONES; ANTIGENS; amino and NUCLEIC ACIDS; ENZYMES; POLYAMINES; and specific CELL MEMBRANE PROTEINS and LIPIDS.


Ultrasonography, Fetal
Prenatal Diagnosis, Ultrasonic
Prenatal Ultrasonography
Ultrasonic Prenatal Diagnosis
Diagnosis, Ultrasonic Prenatal
Diagnosis, Prenatal Ultrasonic
Fetal Ultrasonography
Prenatal Ultrasonic Diagnosis
Ultrasonography, Prenatal
Ultrasonic Diagnosis, Prenatal

The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.


Sperm Maturation Blocking Agents
Antispermatogenic Agents
Blocking Agents, Sperm Maturation
Antispermatogenic Effect
Antispermatogenic Effects

Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis.


Caries, Root
Root Caries
Caries, Cervical
Cervical Caries

Dental caries involving the tooth root, cementum, or cervical area of the tooth.


An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.


Conjugation, Bacterial
Bacterial Conjugation
Conjugation, Genetic
Genetic Conjugation

A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.


Lyme Meningoradiculitis
Mononeuritis Multiplex, Lyme Disease
Neuroborreliosis, Borrelia burgdorferi
Lyme Neuroborreliosis
Lyme Meningoencephalitis
Encephalopathy, Lyme Disease
Meningoencephalitis, Lyme
Lyme Borreliosis, Nervous System
Lyme Disease Mononeuritis Multiplex
Lyme Polyradiculitis
Lyme Disease Encephalopathy
Nervous System Lyme Borreliosis
Nervous System Lyme Disease
Lyme Disease, Nervous System
Lyme Disease, Central Nervous System
Central Nervous System Lyme Disease
Lyme Polyradiculopathy
Peripheral Nervous System Lyme Disease

Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91)


Fertility Agents, Male, Synthetic
Fertility Agents, Male, Hormonal
Synthetic Male Fertility Agents
Fertility Agents, Male
Male Fertility Agents, Synthetic

Compounds which increase the capacity of the male to induce conception.


Experimental High Pressure Neurological Syndrome

High Pressure Neurological Syndrome, Experimental

A syndrome related to increased atmospheric pressure and characterized by tremors, nausea, dizziness, decreased motor and mental performance, and SEIZURES. This condition may occur in those who dive deeply (c. 1000 ft) usually while breathing a mixture of oxygen and helium. The condition is associated with a neuroexcitatory effect of helium.


Racketball
Lacrosse
Racket Ball
Racket Sports
Squash (Sport)
Racquetball
Badminton
Racquet Sports

Games in which players use a racquet to hit a ball or similar type object.


Physiological Stress Reactivity
Abiotic Stress
Physiological Stress Response
Biological Stress
Stress, Physiological
Abiotic Stress Reaction
Abiotic Stress Response
Metabolic Stress Response
Physiological Stress Reaction
Metabolic Stress
Physiological Stress

The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.


Lectins
Isolectin
Isolectins
Animal Lectins


Pericardotomy Pericardectomy Pericardiectomy Pericardiotomy

Surgical excision (total or partial) of a portion of the pericardium. Pericardiotomy refers to incision of the pericardium.


Piperacillin, Tazobactam Drug Combination

Pipercillin Sodium, Tazobactam Sodium Drug Combination

An antibiotic combination product of piperacillin and tazobactam, a penicillanic acid derivative with enhanced beta-lactamase inhibitory activity, that is used for the intravenous treatment of intra-abdominal, pelvic, and skin infections and for community-acquired pneumonia of moderate severity. It is also used for the treatment of PSEUDOMONAS AERUGINOSA INFECTIONS.


Vinca
Lesser Periwinkle
Vinca major
Vinca minor
Periwinkle

A plant genus of the family Apocynaceae.


Epidemic Hemorrhagic Fever Virus
Hemorrhagic Fever Renal Syndrome Virus
Hantaan virus
Hemorrhagic Fever Virus, Korean
Hemorrhagic Fever Virus, Epidemic
Korean Hemorrhagic Fever Virus
HFRS Virus
Hemorrhagic Nephroso-Nephritis Virus

The type species of the genus HANTAVIRUS infecting the rodent Apodemus agrarius and humans who come in contact with it. It causes syndromes of hemorrhagic fever associated with vascular and especially renal pathology.


Cone-Rod Degenerations
Cone-Rod Dystrophy
Rod Cone Dystrophies
Rod-Cone Dystrophy
Cone-Rod Retinal Dystrophy
Cone-Rod Dystrophy 2
Cone-Rod Dystrophies
Retinal Cone-Rod Dystrophy

Genetically heterogeneous and sometimes syndromic (e.g., BARDET BIEDL SYNDROME; and SPINOCEREBELLAR ATAXIA TYPE 7) retinopathies with initial RETINAL CONE involvement. They are characterized by decreased VISUAL ACUITY; COLOR VISION DEFECTS; progressive loss of peripheral vision and night blindness.


Medically Underserved Area
Area, Medically Underserved
National Health Service Corps
Physician Shortage Area
Health Service Corps, National
Medically Underserved Population

Populations designated as having too few primary care providers, high infant mortality, high poverty or a high elderly population.


Laws and Statutes
Model Legislation
Statutes and Laws
Population Law
Constitutional Amendments
Health Legislation as Topic
Legislation as Topic
Health Legislation
Legislation, Health

Works about the enactment of laws and ordinances and their regulation by official organs of a nation, state, or other legislative organization. It refers also to health-related laws and regulations in general or for which there is no specific descriptor.


Quinacrine, (R)-Isomer
Quinacrine Monoacetate
Atebrin
Quinacrine
Atabrine
Quinacrine Dihydrochloride
Quinacrine Monohydrochloride
Acrichine
Quinacrine Hydrochloride
Quinacrine Monomesylate
Quinacrine, (+-)-Isomer
Quinacrine Dihydrochloride, Dihydrate
Quinacrine Dimesylate
Quinacrine Dihyrochloride, (R)-Isomer
Mepacrine
Quinacrine Dihyrochloride, (S)-Isomer
Quinacrine, (S)-Isomer

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.


West Nile Fever Encephalitis
West Nile Fever
West Nile Fever Meningoencephalitis
West Nile Fever Myelitis
Encephalitis, West Nile Fever
WNV Infection
West Nile Virus Infection
West Nile Fever Meningitis

A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)


SCE-1365
Cefmenoxime
Cefmenoxime Hydrochloride (2:1)
Abbott-50192
Cefmax
Cefmenoxime Hydrochloride

A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.


Fetal Termination, Selective
Pregnancy Reduction, Multifetal
Fetal Reduction
Multifetal Pregnancy Reduction
Embryo Reduction

Selective abortion of one or more embryos or fetuses in a multiple gestation pregnancy. The usual goal is to improve the outcome for the remaining embryos or fetuses.


46, XX Testicular Disorders of Sex Development

46, XX Testicular Disorder of Sex Development

Congenital conditions in individuals in which male GONADS develop in a genetic female (female to male sex reversal).


Embolism, Intracranial
Embolism, Brain
Brain Emboli
Cerebral Emboli
Cerebral Embolism
Brain Embolism
Intracranial Embolism

Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.


Physiological Processes
Physiological Phenomena
Physiological Phenomenon
Physiological Concepts
Physiological Process

The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.


Regulatory Proteins, Viral
Viral Accessory Proteins
Viral Regulatory Proteins
Viral Regulatory and Accessory Proteins

Proteins which regulate the rate of transcription of viral structural genes.


Trivalent Live Attenuated Influenza Vaccine

Intranasal Live-Attenuated Influenza Vaccine

Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed and attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The flu vaccines may be mono- or multi-valent, which contains one or more INFLUENZAVIRUS A and INFLUENZAVIRUS B strains.


Permeability, Microvascular
Microvascular Permeability
Capillary Permeability
Permeability, Capillary
Vascular Permeability

The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.


Adjustment of BRAIN WAVES from two or more neuronal groups within or across a brain structure (e.g., cortical and limbic brain structures) to become uniform in EEG oscillation patterns in response to a stimulus. It is interpreted as a brain integration sign during many processes such as learning, memory, and perception and involves reciprocal neural connections.


Golgi Matrix Proteins
GRASP Golgi Matrix Proteins
Golgi Reassembly Stacking Proteins
Golgins

Proteins on the cytoplasmic side of the GOLGI APPARATUS cisternae that tether the cisternae to each other or to the transport vesicles of the TRANS-GOLGI NETWORK to maintain the Golgi structure and function.


RNA Denaturation
DNA Denaturation
DNA Melting
Nucleic Acid Denaturation

Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.


Serine Proteinase Inhibitors, Endogenous

Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.


Episcopal Church
Methodists
Seventh-Day Adventists
Presbyterian Church
Protestants
Baptist Church
Methodist Church
Presbyterians
Protestantism
Baptists
Lutherans
Anglican Church
Anglicans
Protestant Ethics
Episcopalians
Society of Friends
Lutheran Church
Quakers

The name given to all Christian denominations, sects, or groups rising out of the Reformation. Protestant churches generally agree that the principle of authority should be the Scriptures rather than the institutional church or the pope. (from W.L. Reese, Dictionary of Philosophy and Religion, 1999)


Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1

A thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIONE and the C-terminal glycine residue of UBIQUITIN.


Supratentorial Tumors
Supratentorial Neoplasms, Malignant
Malignant Supratentorial Neoplasms
Cancer, Supratentorial
Supratentorial Neoplasms, Primary
Supratentorial Neoplasms
Benign Supratentorial Neoplasms
Supratentorial Neoplasms, Benign
Primary Supratentorial Neoplasms
Neoplasms, Supratentorial

Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.


ApoC
Apoproteins C
Apolipoproteins C
Apo C
Apoprotein (C)
Apo-C

A group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.


Cryptenamine
Veralba
Protoverin
Protalba
Protoveratrines
Protoveratrine A
Tensatrin
Neoprotoveratrin
Veratetrin

Mixtures of closely related hypotensive alkaloids from Veratrum album (Liliaceae). They have been used in the treatment of hypertension but have largely been replaced by drugs with fewer adverse effects.


A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.


CA1 Stratum Radiatum
CA1 Field of Hippocampus
Cornu Ammonis 1 Area
Regio Superior of Hippocampus
Hippocampus CA1 Field
CA1 Pyramidal Cell Layer
Hippocampal Sector CA1
CA1 Pyramidal Cell Area
CA1 Region, Hippocampal
Stratum Radiatum, CA1
CA1 Stratum Pyramidale

The pyramidal cell layer (stratum pyramidale) of the HIPPOCAMPUS CA1 FIELD.


Periapical Fibrous Dysplasia
Cementoma
Mandibular Cementifying Fibroma
Ossifying Fibroma of Maxilla
Cementifying Fibroma of Maxilla
Cemento-Ossifying Fibroma
Ossifying Fibroma of Mandible
Cementifying Fibroma of Mandible
Maxillary Cementifying Fibroma

An odontogenic fibroma in which cells have developed into cementoblasts and which consists largely of cementum.


Immunodeficiency Syndrome, Severe Combined

Severe Combined Immunodeficiency Syndrome

Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).


Costimulatory and Inhibitory T-Lymphocyte Receptors

Receptors, Costimulatory and Inhibitory, T-Lymphocyte

Costimulatory and Inhibitory T-Cell Receptors

A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. Although commonly referred to as costimulatory receptors, some of the receptors have inhibitory effects such as inducing PERIPHERAL TOLERANCE.


Choroid
Sattler's Layer
Haller Layer
Sattler Layer
Choriocapillaris
Haller's Layer

The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.


Injections, Intraspinal
Intraspinal Injections
Intrathecal Injections
Injections, Intrathecal
Injections, Spinal
Spinal Injections

Introduction of therapeutic agents into the spinal region using a needle and syringe.


Pituitary-Specific Transcription Factor Pit-1

A POU domain factor that regulates expression of GROWTH HORMONE; PROLACTIN; and THYROTROPIN-BETA in the ANTERIOR PITUITARY GLAND.


Spastic Paraplegia, X-Linked Recessive, Hereditary

Hereditary Motor And Sensory Neuropathy V

Hereditary Motor and Sensory Neuropathy 5

Spastic Paraplegia, Hereditary, X-Linked Recessive

HMSN V (Hereditary Motor and Sensory Neuropathy Type V)

Hereditary Autosomal Recessive Spastic Paraplegia

Autosomal Dominant Spastic Paraplegia Hereditary

Spastic Paraplegia, Hereditary, Autosomal Recessive

Autosomal Dominant Hereditary Spastic Paraplegia

Hereditary X-Linked Recessive Spastic Paraplegia

Hereditary Motor-Sensory Neuropathy with Pyramidal Signs

X Linked Recessive Hereditary Spastic Paraplegia

X-Linked, Spastic Paraplegia, Hereditary

Hereditary, Spastic Paraplegia, X-Linked Recessive

Spastic Paraplegia, Autosomal Dominant, Hereditary

Type V Hereditary Motor and Sensory Neuropathy

Autosomal Recessive Hereditary Spastic Paraplegia

Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant

Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia

Spastic Paraplegia, Hereditary, Autosomal Dominant

X-linked Recessive Hereditary Spastic Paraplegia

Hereditary Spastic Paraplegia, Autosomal Recessive

Hereditary Autosomal Dominant Spastic Paraplegia

Spastic Paraplegia, Autosomal Recessive, Hereditary

Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy

Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant

Autosomal Recessive Spastic Paraplegia, Hereditary

Hereditary, Spastic Paraplegia, Autosomal Dominant

A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)


Diterpenoids
Labdanes
Norditerpenes
Diterpenes
Diterpenes, Labdane
Cembranes
Norditerpenoids
Diterpenes, Cembrane

Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.


Treatment Centers, Drug
Rehabilitation Centers, Drug
Treatment Centers, Substance Abuse
Substance Abuse Treatment Centers
Treatment Centers, Drug Abuse
Drug Rehabilitation Center
Drug Treatment Centers
Rehabilitation Center, Drug
Drug Rehabilitation Centers
Drug Abuse Treatment Centers

Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.


Eurycoma
Long Jack
Eurycoma longifolia
Tongkat Ali

A plant genus of the family SIMAROUBACEAE. Members contain quassinoids. There is Malaysian folk use of these plants for male virility.


Glycochenodeoxycholate
Glycine Chenodeoxycholate
Chenodeoxycholylglycine
Glycochenodeoxycholic Acid

A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.


Patau's Syndrome
Trisomy 13
Chromosome 13 Trisomy Syndrome
Chromosome 13 Duplication
Patau Syndrome
Bartholin-Patau Syndrome
Trisomy 13 Syndromes
Mosaic Trisomy 13 Syndrome
Complete Trisomy 13 Syndrome
Trisomy 13 Syndrome

A chromosome disorder associated with TRISOMY of all or part of CHROMOSOME 13. Clinical manifestations include CONGENITAL HEART DEFECTS (e.g., PATENT DUCTUS ARTERIOSUS), facial malformations (e.g., CLEFT LIP; CLEFT PALATE; COLOBOMA; MICROPHTHALMIA); HYPOTONIA, digit malformations (e.g., POLYDACTYLY or SYNDACTYLY), and SEIZURES and severe INTELLECTUAL DISABILITY associated with NERVOUS SYSTEM MALFORMATIONS.


Chronic Interstitial Cystitis
Interstitial Cystitis
Cystitis, Interstitial
Bladder Pain Syndrome
Cystitis, Chronic Interstitial
Painful Bladder Syndrome
Interstitial Cystitis, Chronic

A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.


Octopodiformes Octopus Octopuses Octopoda

An eight-armed cephalopod mollusk belonging to the order Octopoda. It includes the octopus as food.


Cinchona pubescens
Cinchona
Peruvian Bark
Red Cinchona

The raw material from which QUININE was extracted.


Narcotic and Drug Control
Drug Control
Drug and Narcotic Control
Pharmaceutical Policy
Drug Regulations
Pharmaceutic Policy
Narcotic Control

Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.


Type I Antifreeze Proteins
Fish Type I APF
Antifreeze Proteins, Type I
Type I Fish Antifreeze Proteins
Fish Antifreeze Proteins, Type I

A subclass of ANTIFREEZE PROTEINS that are 3-5 kDa in size and contain a single alanine-rich amphipathic alpha-helix.


Substances that are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.


Denture, Partial, Temporary
Dental Prosthesis, Interim
Interim Dental Prosthesis
Interim Prosthesis Dental

A partial denture intended for short-term use in a temporary or emergency situation.


Harbor Porpoise
Phocoena
Common Porpoise
Harbour Porpoise
Phocoena phocoena

A genus of PORPOISES, in the family Phocoenidae, comprised of several species. They frequent coastal waters, bays, estuaries, and the mouths of large rivers.


para-Hydroxybenzoic Acids
4-Hydroxybenzoic Acids
Parabens

Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)


Pteroylpolyglutamates
Pteroylpolyglutamic Acids
Polyglutamate Folates
Folate Polyglutamates

Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.


Standards, Reference
Standardization
Standard Preparations
Standards
Reference Standards
Preparations, Standard

A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.


Balaenoptera musculus
Balaenoptera borealis
Balaenoptera brydei
Blue Whale
Bryde's Whale
Sei Whale
Balaenoptera

A genus of WHALES in the family Balaenopteridae, consisting of five species: Blue Whale, Bryde's Whale, FIN WHALE, Sei Whale, and MINKE WHALE. They are distinguished by a relatively slender body, a compressed tail stock, and a pointed snout.


Waste Water Decolorization
Water Decolorization
Wastewater Decolorization

The removal of DYES; STAINS; or other COLORING AGENTS, natural or synthetic, from water sources by various processes such as ADSORPTION; BIOREMEDIATION; enzymatic digestion; and ELECTROLYSIS.


Sclerosing Agents
Sclerosing Solutions
Sclerosants
Sclerosing Injections
Injections, Sclerosing
Sclerosing Drugs

Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.


Protein Tyrosine Phosphatase, Receptor Type, G

Receptor-Like Protein Tyrosine Phosphatases, Class 5

Protein Tyrosine Phosphatase, Receptor Type G

Receptor Protein Tyrosine Phosphatase-beta

Receptor Protein Tyrosine Phosphatase-zeta

Receptor-Like Protein Tyrosine Phosphatases, Class V

Protein Tyrosine Phosphatase, Receptor Type Z

Receptor Protein Tyrosine Phosphatase zeta-beta

Receptor Protein Tyrosine Phosphatase gamma

Protein Tyrosine Phosphatase, Receptor-Type Z

A subclass of receptor-like protein tryosine phosphatases that contain an extracellular fibronectin III-like domain along with a carbonic anhydrase-like domain.


Plant Spermatogenesis
Spermatogenesis, Plant
Gametogenesis, Plant
Microsporogenesis
Megasporogenesis
Plant Gametogenesis
Antheridiogenesis

The process of germ cell development in plants, from the primordial PLANT GERM CELLS to the mature haploid PLANT GAMETES.


Clear Dental Braces
Invisalign
Clear Aligner Appliances
Orthodontic Appliances, Removable

Dental devices such as RETAINERS, ORTHODONTIC used to improve gaps in teeth and structure of the jaws. These devices can be removed and reinserted at will.


Duct of Santorini
Wirsung's Duct
Santorini's Duct
Main Pancreatic Duct
Pancreatic Ducts
Accessory Pancreatic Duct
Duct of Wirsung
Accessory Pancreatic Duct of Santorini
Duodenal Papilla, Minor

The minor duodenal papilla (when present) connects the accessory pancreatic duct to the DUODENUM.


Todd's Paralysis
Palsy
Paralysis
Plegia
Todd Paralysis

A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)


Cat Flea
Ctenocephalides felis
Ctenocephalides

A genus of FLEAS in the family Pulicidae. It includes the cat flea (Ctenocephalides felis), one of the most common species on earth.


Antisacer
Epamin
Diphenylhydantoin
Fenitoin
Phenytoin Sodium
Dihydan
Hydantol
Dilantin
5,5-diphenylimidazolidine-2,4-dione
5,5-Diphenylhydantoin
Sodium Diphenylhydantoinate
Difenin
Phenytoin
Epanutin

An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.


Minurin
Adiuretin SD
1-Deamino-8-D-arginine Vasopressin
Octostim
Apo-Desmopressin
Desmogalen
DDAVP
Octim
Desmopressine Ferring
Nocutil
1-Desamino-8-arginine Vasopressin
Vasopressin, Deamino Arginine
Desmopressin Monoacetate
Minirin
Desmospray
Adiuretin
Deamino Arginine Vasopressin
Desmopressin Monoacetate, Trihydrate
Desmotabs
Desmopressin Acetate
Desmopressin

A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.


Transanal Endoscopic Surgical Procedures

Surgical procedures performed through the anus using a PROCTOSCOPE.


Inclusion Bodies, Viral
Negri Bodies
Viral Inclusion Bodies
Negri Body

An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.


A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.


Valuation, Economic Life
Economic Values, Life
Respect for Life
Life Economic Value
Right to Life
Life Valuation, Economic
Economic Value of Life
Value of Life
Sanctity of Life
Economic Life Valuation
Economic Value, Life
Life Economic Values

The evaluation of the monetary value of a life lost or a life saved.


Wangiella
Cladosporium werneckii
Phialophora gougerotii
Exophiala
Phialophora jeanselmei
Exophiala jeanselmei

A normally saprophytic mitosporic Chaetothyriales fungal genus. Infections in humans include PHAEOHYPHOMYCOSIS; and PERITONITIS.. Exophiala jeanselmei (previously Phialophora jeanselmei) is an etiological agent of MYCETOMA.


Laparoscopic Heller Cardiomyotomy
Heller's Myotomy
Laparoscopic Heller Myotomy
Heller Groeneweldt Operation
Heller Groeneweldt Surgery
Heller Myotomy
Heller Operation

Surgical incision of the lower esophageal sphincter near the CARDIA often used to treat ESOPHAGEAL ACHALASIA.


A subgenus of Naja, also known as the water cobra, that is indigenous to Central and Western Africa.


Partial Seizures, Simple, Consciousness Preserved

Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)


An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.


Melocin
Mezlocillin Sodium
Mezlin
Meslocillin
Baypen
Bay-f 1353
Mezlocillin
Mezlocilline

Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.


Bruguiera
Ceriops
Cassipourea
Mangrove, Red
Rhizophoraceae
Mangrove, American
Rhizophora
Kandelia
Rhizophora mangle

A plant family of the order Rhizophorales, subclass Rosidae, class Magnoliopsida, that includes mangrove trees.


Bifunctional Aspartokinase-Homoserine Dehydrogenase 1

Aspartokinase I Homoserine Dehydrogenase I

Aspartokinase II Homoserine Dehydrogenase II

Bifunctional Aspartokinase-Homoserine Dehydrogenase 2

A bifunctional protein consisting of aspartokinase, and homoserine dehydrogenase activities. It is found primarily in BACTERIA and in PLANTS.


Randomized Response Technique
Community Surveys
Methodology, Survey
Nonrespondents
Surveys
Questionnaires
Respondents
Survey Methodology
Questionnaire Design
Repeated Rounds of Survey
Surveys and Questionnaires
Survey Methods
Baseline Survey

Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.


Surgery, Laryngoscopic
Laryngoscopy
Surgical Procedures, Laryngoscopic
Laryngoscopic Surgical Procedures
Laryngoscopic Surgery

Examination, therapy or surgery of the interior of the larynx performed with a specially designed endoscope.


Postoperative Procedures
Postoperative Care
Care, Postoperative
Procedures, Postoperative

The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)


Neuralgia, Pudendal
Pudendal Neuropathy
Pudendal Nerve Entrapment
Pudendal Neuralgia
Pudendal Nerve Entrapment Syndrome
Pudendal Canal Entrapment Syndrome

Pain associated with a damaged PUDENDAL NERVE. Clinical features may include positional pain with sitting in the perineal and genital areas, sexual dysfunction and FECAL INCONTINENCE and URINARY INCONTINENCE.


Nidrel
Baypress
Nitre AbZ
Nitrendipin Apogepha
Nitre-Puren
Nitrendipin-ratiopharm
Bay e 5009
nitrendipin-corax
Nitregamma
Nitren 1A Pharma
Nitrendepat
Nitrensal
Nitrendi Biochemie
Nitrepress
Nitren Lich
Trendinol
Tensogradal
nitrendipin von ct
Nitrendipin Atid
Nitren acis
Nitrendipin Lindo
Nitrendipino Bayvit
Nitrendipin Heumann
Gericin
Nitrendimerck
Balminil
Jutapress
Niprina
Nitrendipino Ratiopharm
Nitrendipin Jenapharm
Nitrendipin AL
Nitrendipine
Nitrendipin beta
Nitrendipin Stada
Nitrendipin Basics
Bayotensin
Vastensium
Nitrend KSK
Nitrendidoc
Baypresol

A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.


Tylan
Tylosine
Tylosin Hydrochloride
Tylosin
Tylosin Tartrate
Tylosin Tartrate (Salt)
Fradizine

Macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.


Glucose Transport-Inducing Protein
Erythrocyte Band 4.5 Protein
Band 4.5 Preactin
Hexose Transporter
Hexose Transport Proteins
Monosaccharide Transport Proteins

A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.


Methylergometrine Maleate
Methylergometrin
Methergin
Methylergonovine Maleate
Methylergobasin
Methylergonovine
Methergine
Méthergin
Methylergometrine

A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)


Hyper-IgM Immunodeficiency Syndrome Type 3

Hyper-IgM Immunodeficiency Syndrome, Type 2

Immunodeficiency with Hyper-IgM Syndrome

Hyper-IgM Immunodeficiency Syndrome, Type 3

Hyper-IgM Immunodeficiency Syndrome Type 2

Hyper-IgM Immunodeficiency Syndrome Type 5

Hyper-IgM Immunodeficiency Syndrome, Type 5

Hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding CD40 ANTIGEN.


Osteoarthritis of the Spine
Spinal Osteoarthritis
Lumbar Osteoarthritis
Spine Osteoarthritis
Osteoarthritis, Spine
Osteoarthritis of Spine
Osteoarthritis, Lumbar

A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).


An ADRENERGIC BETA-2 RECEPTOR AGONIST with a prolonged duration of action. It is used to manage ASTHMA and in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.


Frangula purshiana
Rhamnus purshiana
Frangula alnus
Cascara Buckthorn
Frangula
Sacred Bark
Rhamnus
Rhamnus frangula
Cascara Sagrada

Dried aged bark of a buckthorn, Rhamnus purshiana, that contains the anthraquinone EMODIN and cascarosides. It is used as a laxative (CATHARTICS).


Cold Stress Peptides
Cold Stress Proteins
Cold Shock Peptides
Cold Shock Proteins
Cold Stress Proteins and Peptides
Cold Shock Proteins and Peptides

Cellular proteins and peptides that are induced in response to cold stress. They are found in a broad variety of prokaryotic and eukaryotic organisms.


Hospital Organization and Administration

Organization and Administration, Hospital

Management of the internal organization of the hospital.


Butyrate
Butyric Acids
Butanoic Acids
n-Butyrate
Butyrates

4-carbon acids, salts, and derivatives of BUTYRIC ACID.


Complement Component 1 Inactivator Proteins

Complement C1s Esterase Inhibitor Proteins

Complement C1r Protease Inhibitor Proteins

Serum proteins that inhibit, antagonize, or inactivate COMPLEMENT C1 or its subunits.


Hyperinsulinemic Hypoglycemia, Familial, 1

Hypoglycemia, Hyperinsulinemic, of Infancy

Hyperinsulinemic Hypoglycemia, Familial, 2

Hyperinsulinemic Hypoglycemia Due to Focal Adenomatous Hyperplasia

Familial Hyperinsulinemic Hypoglycemia 1

Persistent Hyperinsulinemia Hypoglycemia of Infancy

A familial, nontransient HYPOGLYCEMIA with defects in negative feedback of GLUCOSE-regulated INSULIN release. Clinical phenotypes include HYPOGLYCEMIA; HYPERINSULINEMIA; SEIZURES; COMA; and often large BIRTH WEIGHT. Several sub-types exist with the most common, type 1, associated with mutations on an ATP-BINDING CASSETTE TRANSPORTERS (subfamily C, member 8).


Brazil Nuts
Bertholletia excelsa
Brazil Nut Tree
Bertholletia

A plant genus of the family Lecythidaceae which is the source of edible Brazil nuts.


Antithyroid Effect
Antithyroid Effects
Goitrogens
Antithyroid Agents
Thyroid Antagonists
Antithyroid Drugs

Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.


CbhI Protein
Cellobiohydrolase A
1,4-beta-D-Glucan Cellobiohydrolase
Exoglucanase II
Cellobiohydrolase II
Cellulose 1,4-beta-Cellobiosidase
Cellobiohydrolase I
Beta-Glucancellobiohydrolase
Exo-Cellobiohydrolase
Cellobiohydrolase
CEL1 Protein

An exocellulase with specificity for the hydrolysis of 1,4-beta-D-glucosidic linkages in CELLULOSE and cellotetraose. It catalyzes the hydrolysis of terminal non-reducing ends of beta-D-glucosides with release of CELLOBIOSE.


Hemo 141
Dicynone
Etamsylate
Ethamsylate
Dicynene
Dicinone
Altodor
Cyclonamine

Benzenesulfonate derivative used as a systemic hemostatic.


Euglobulin Clot Lysis Time
Euglobulin Lysis Time
Plasma Clot Lysis Time
Fibrin Clot Lysis Time
Whole Blood Clot Lysis Time
Clot Lysis Time

A measure of the time it takes for dissolution of a FIBRIN clot from the euglobulin fraction of blood.


Codon, Stop
Opal Stop Codon
TAA Codon
Stop Signal, Translation
UAA Codon
Codon, Opal Stop
UGA Codon
Amber Stop Codon
Codon, Ochre Stop
Codon, Terminator
Amber Terminator Codon
Stop Codon UAA
TAG Codon
UAG Codon
TGA Codon
Stop Codon
UAA Stop Codon
UAG Stop Codon
Codon, Termination
Stop Codon UGA
UGA Stop Codon
Stop Codon UAG
Codon, Amber Stop
Opal Codon
Ochre Stop Codon
Amber Codon
Terminator Codon
Ochre Codon

Any codon that signals the termination of genetic translation (TRANSLATION, GENETIC). PEPTIDE TERMINATION FACTORS bind to the stop codon and trigger the hydrolysis of the aminoacyl bond connecting the completed polypeptide to the tRNA. Terminator codons do not specify amino acids.


Oxychlorochin
Hydroxychlorochin
Oxychloroquine
Hydroxychloroquine Sulfate
Hydroxychloroquine Sulfate (1:1) Salt
Hydroxychloroquine
Plaquenil

A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)


Isoantigen Alloantigens Alloantigen Isoantigens

Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.


Pet Facilitated Therapy
Animal Assisted Therapy
Animal Facilitated Therapy
Pet Therapy

The use of live animal as a means of therapy


Anemia, Hemolytic, Autoimmune
Cold Agglutinin Disease
Cold Antibody Hemolytic Anemia
Hemolytic Anemia, Autoimmune
Anemia, Hemolytic, Cold Antibody
Autoimmune Hemolytic Anemia
Idiopathic Autoimmune Hemolytic Anemia
Acquired Autoimmune Hemolytic Anemia
Autoimmune Haemolytic Anaemia
Anemia, Hemolytic, Idiopathic Acquired
Cold Antibody Disease

Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.