Branched-Chain Oligosaccharides
Oligosaccharides, Branched-Chain

Oligosaccharides containing various types of glycosidic linkages that yield branching or antennae. The number of antennae (such as bi-, tri-, tetra-, or penta-antennary) in the oligosaccharides on the PROTEOGLYCANS; GLYCOPROTEINS; or LIPOPOLYSACCHARIDES contribute to their biological activities, such as receptor binding and metabolism.


A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and ENDOMETRIOSIS. As a contraceptive (CONTRACEPTIVE AGENTS), it has usually been administered in combination with MESTRANOL.


Riley Virus
Lactate Dehydrogenase Virus
Lactic Dehydrogenase Virus
Lactate dehydrogenase-elevating virus

A species ARTERIVIRUS, occurring in a number of transplantable mouse tumors. Infected mice have permanently elevated serum levels of lactate dehydrogenase.


Velopharyngeal Insufficiency
Inadequate Velopharyngeal Closure
Palatopharyngeal Incompetence
Velopharyngeal Incompetence

Failure of the SOFT PALATE to reach the posterior pharyngeal wall to close the opening between the oral and nasal cavities. Incomplete velopharyngeal closure is primarily related to surgeries (ADENOIDECTOMY; CLEFT PALATE) or an incompetent PALATOPHARYNGEAL SPHINCTER. It is characterized by hypernasal speech.


Exudates and Transudates
Transudates
Transudates and Exudates
Exudates

Exudates are fluids, CELLS, or other cellular substances that are slowly discharged from BLOOD VESSELS usually from inflamed tissues. Transudates are fluids that pass through a membrane or squeeze through tissue or into the EXTRACELLULAR SPACE of TISSUES. Transudates are thin and watery and contain few cells or PROTEINS.


Nursing Staff
Nursing Staffs
Staff, Nursing
Staffs, Nursing

Personnel who provide nursing service to patients in an organized facility, institution, or agency.


Schizosaccharomyces pombe Proteins
S pombe Proteins
Fission Yeast Proteins

Proteins obtained from the species Schizosaccharomyces pombe. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.


NADPH-Dependent 20 alpha-Hydroxysteroid Oxidoreductase

17 beta, 20 alpha-Hydroxysteroid Dehydrogenase

An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha-hydroxysteroids, such as from PROGESTERONE to 20-ALPHA-DIHYDROPROGESTERONE.


A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)


CDKN1C Protein
p57KIP2 Protein
Cyclin Kinase Inhibitor Protein 2
Cyclin-Dependent Kinase Inhibitor 1C
p57 KIP2 Protein
Cyclin-Dependent Kinase Inhibitor p57

A potent inhibitor of CYCLIN-DEPENDENT KINASES in G1 PHASE and S PHASE. In humans, aberrant expression of p57 is associated with various NEOPLASMS as well as with BECKWITH-WIEDEMANN SYNDROME.


Coronary Circulation
Circulation, Coronary

The circulation of blood through the CORONARY VESSELS of the HEART.


Infectious Hepatitis Virus
Hepatovirus
Hepatitis Virus, Infectious

A genus of PICORNAVIRIDAE causing infectious hepatitis naturally in humans and experimentally in other primates. It is transmitted through fecal contamination of food or water. HEPATITIS A VIRUS is the type species.


16S rRNA
16S Ribosomal RNA
RNA, Ribosomal, 16S

Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.


Sex Cord-Gonadal Stromal Tumors
Sex Cord-Stromal Tumor
Gynandroblastoma

A sex cord-gonadal stromal tumor, composed of cells of both the OVARY and the TESTIS. It produces both male and female GONADAL STEROID HORMONES.


An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.


A type of chromogranin which was initially characterized in the ANTERIOR PITUITARY GLAND. It is found in several species including human, rat, mouse, and others. Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS.


Choroid Plexus Papilloma
Papilloma of Choroid Plexus
Papilloma, Choroid Plexus

A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)


ATP-Binding Cassette, Sub-Family B, Member 3

ATP Binding Cassette Transporter, Subfamily B, Member 3

ATP Binding Cassette Transporter, Sub-Family B, Member 3

ATP-binding cassette, subfamily B, protein that functions in the transport of ANTIGENS from the CYTOPLASM to the ENDOPLASMIC RETICULUM for association with HISTOCOMPATIBILITY ANTIGENS CLASS I peptides. It functions as a heterodimer with ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 2.


Pumps, Infusion
Intravenous Drug Delivery Systems
Infusion Pumps
Infusors
Infusion Pumps, External
Drug Infusion Systems
Perfusion Pumps

Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.


CD55 Antigen
Decay-Accelerating Factor
Complement Decay-Accelerating Factor
CD55 Antigens
Antigens, CD55

GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.


A peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an antihyperlipoproteinemic agent.


Protocol Drug Therapy, Computer-Assisted

Adjunctive computer programs in providing drug treatment to patients.


Interleukin-1 Receptor, Type 2
Receptors, Interleukin-1 Type II
Interleukin-1 Receptor Type II
Antigens, CDw121b
CDw121b Antigens
Interleukin-1 Receptors Type II

An interleukin-1 receptor subtype that competes with the INTERLEUKIN-1 RECEPTOR TYPE I for binding to INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The interleukin-1 type II receptor appears to lack signal transduction capability. Therefore it may act as a "decoy" receptor that modulates the activity of its ligands. Both membrane-bound and soluble forms of the receptor have been identified.


Minor Lymphocyte Stimulatory Determinants

Endogenous superantigens responsible for inducing strong proliferative responses in T-cells in mixed lymphocyte reactions (see LYMPHOCYTE CULTURE TEST, MIXED). They are encoded by mouse mammary tumor viruses that have integrated into the germ line as DNA proviruses (MINOR LYMPHOCYTE STIMULATORY LOCI).


Recording of the average amplitude of the resting potential arising between the cornea and the retina in light and dark adaptation as the eyes turn a standard distance to the right and the left. The increase in potential with light adaptation is used to evaluate the condition of the retinal pigment epithelium.


Germinal Center Kinase Family
Germinal Center Kinases

Serine-threonine kinases characterized by an N-terminal STE20 kinase domain.


Leukemia Inhibitory Factor Receptor alpha Subunit

A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.


Rheography
Plethysmography, Impedance
Impedance Plethysmography

Recording changes in electrical impedance between electrodes placed on opposite sides of a part of the body, as a measure of volume changes in the path of the current. (Stedman, 25th ed)


A departure from the normal gait in animals.


Arginine, L-Isomer
Arginine Hydrochloride
DL-Arginine Acetate, Monohydrate
L-Arginine
Arginine

An essential amino acid that is physiologically active in the L-form.


Influenza Virus, Canine, H3N2 Subtype
Influenza A Virus, H3N2 Subtype
H3N2 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.


Periodic Acid-Schiff Reaction
PAS Reaction

A histochemical technique for staining carbohydrates. It is based on PERIODIC ACID oxidation of a substance containing adjacent hydroxyl groups. The resulting aldehydes react with Schiff reagent to form a colored product.


An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.


Retropharyngeal Abscess
Abscess, Retropharyngeal

An accumulation of purulent material in the space between the PHARYNX and the CERVICAL VERTEBRAE. This usually results from SUPPURATION of retropharyngeal LYMPH NODES in patients with UPPER RESPIRATORY TRACT INFECTIONS, perforation of the pharynx, or head and neck injuries.


A plant species of the Salvia genus known as a spice and medicinal plant.


Personality Assessment
Assessment, Personality

The determination and evaluation of personality attributes by interviews, observations, tests, or scales. Articles concerning personality measurement are considered to be within scope of this term.


Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.


Fanconi Anemia Complementation Group E Protein

Fanconi Anemia Group E Complementing Protein

A Fanconi anemia complementation group protein that interacts with FANCC PROTEIN and FANCD2 PROTEIN. It promotes the accumulation of FANCC protein in the CELL NUCLEUS.


A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.


Surgical treatment of pulmonary tuberculosis whereby the lung is totally or partially, temporarily or permanently, immobilized. The procedure was based on the popular concept that collapsing the affected portion of a tuberculous lung allowed the infected area to rest and thereby recover. At the beginning of the 20th century artificially induced pneumothorax (PNEUMOTHORAX, ARTIFICIAL) was popular. Later a variety of other techniques was used to encourage collapse of the infected portion of the lung: unilateral phrenic nerve division, PNEUMONOLYSIS, pneumoperitoneum (PNEUMOPERITONEUM, ARTIFICIAL), and THORACOPLASTY. Collapse therapy has declined since the advent of antitubercular chemotherapy. (Stedman, 25th ed; from Sabiston Jr, Textbook of Surgery, 14th ed, p1733-4)


Genes, sor
Genes, vif
sor Genes
Genes, Q
Genes, A
vif Genes

DNA sequences that form the coding region for the vif (virion infectivity factor) protein that is important for the generation of infectious virions in human immunodeficiency virus (HIV). The former name of this gene was sor (short open reading frame).


Physiologically inactive substances that can be converted to active enzymes.


An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.


Healthy Years Equivalents
QALY
Quality-Adjusted Life Years
Quality Adjusted Life Years
Adjusted Life Years

A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)


Interleukin-12b
IL-12p40
Interleukin-12 beta Chain
Interleukin-23 Subunit p40
Interleukin-12,23 p40 Subunit
Interleukin-12 Subunit p40

A cytokine subunit that is a component of both interleukin-12 and interleukin-23. It binds to the INTERLEUKIN-12 SUBUNIT P35 via a disulfide bond to form interleukin-12 and to INTERLEUKIN-23 SUBUNIT P19 to form interleukin-23.


CYP1 Family
Cytochrome P450 Family 1
CYP1 Enzymes

A cytochrome P450 enzyme family whose members function primarily in the metabolism of XENOBIOTICS, including drugs and POLYCYCLIC AROMATIC HYDROCARBONS.


Doctor-Patient Relations
Physician Patient Relationship
Physician Patient Relations
Physician-Patient Relations
Doctor Patient Relations

The interactions between physician and patient.


Tartrated Antimony
Tartar Emetic
Potassium Antimonyltartrate
Antimony Potassium Tartrate

A schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.


Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.


Bone Diseases, Developmental
Bone Dysplasias
Developmental Bone Disease

Diseases resulting in abnormal GROWTH or abnormal MORPHOGENESIS of BONES.


Infections with fungi of the genus ASPERGILLUS.


Krukenberg's Tumor
Krukenberg Tumor
Krukenberg Carcinoma

Mucocellular carcinoma of the ovary, usually metastatic from the gastrointestinal tract, characterized by areas of mucoid degeneration and the presence of signet-ring-like cells. It accounts for 30%-40% of metastatic cancers to the ovaries and possibly 1%-2% of all malignant ovarian tumors. The lesions may not be discovered until the primary disease is advanced, and most patients die of their disease within a year. In some cases, a primary tumor is not found. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1685)


Tyrosine Hydroxylase
Tyrosine 3-Monooxygenase

An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.


Group Practice Hospitals
Hospitals, Group Practice

Hospitals organized and controlled by a group of physicians who practice together and provide each other with mutual support.


Medical Legislation
Legislation, Medical

Laws and regulations, pertaining to the field of medicine, proposed for enactment or enacted by a legislative body.


Tissues, cells or organs transplanted between animals of different species.


Gram-Negative Anaerobic Straight, Curved, and Helical Rods

Gram Negative Anaerobic Straight, Curved, and Helical Rods

A group of anaerobic, rod-shaped bacteria that show up as pink (negative) when treated by the Gram-staining method.


Pancreatic Insufficiency
Exocrine Pancreatic Insufficiency

A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.


An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA.


Acute VIRAL CNS INFECTION affecting mammals, including humans. It is caused by RABIES VIRUS and usually spread by contamination with virus-laden saliva of bites inflicted by rabid animals. Important animal vectors include the dog, cat, bat, fox, raccoon, skunk, and wolf.


Obturators, Palatal
Cleft Palate Prosthesis
Palatal Obturators

Appliances that close a cleft or fissure of the palate.


Prinzmetal Angina
Prinzmetal's Angina
Angina Pectoris, Variant

A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.


Knee Medial Collateral Ligament
Tibial Collateral Ligament
Collateral Ligament, Medial, Knee
Ligamentum Collaterale Tibiale
Medial Ligament of Knee
Medial Collateral Ligament, Knee

The ligament that travels from the medial epicondyle of the FEMUR to the medial margin and medial surface of the TIBIA. The medial meniscus is attached to its deep surface.


Swine Fever, African
Wart-Hog Disease
Asfivirus Infection
African Swine Fever Virus Infection
African Swine Fever

A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros).


Sodium Potassium Chloride Symporter Inhibitors

Bumetanide Sensitive Na-K-Cl-Transporter Inhibitors

Sodium Potassium Chloride Cotransporter Inhibitors

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA.


Removal of only the breast tissue and nipple and a small portion of the overlying skin.


Formulations for the nutrition of infants that are substituted for BREAST MILK.


Cytochrome P450 Family 11
CYP11 Enzymes
CYP11 Family

A cytochrome P450 enzyme family whose members localize to the INNER MITOCHONDRIAL MEMBRANE where they function in the biosynthesis of STEROIDS.


Uridine Phosphates
Uracil Nucleotides
Uridine Nucleotides

A group of pyrimidine NUCLEOTIDES which contain URACIL.


The part of the pelvis, inferior to the pelvic brim, that comprises both the pelvic cavity and the part of the PERINEUM lying inferior to the PELVIC DIAPHRAGM.


HTLV-III Receptors
AIDS Virus Receptors
Receptors, HIV
Receptors, HTLV-III
HIV Receptors
Receptors, AIDS Virus

Cellular receptors that bind the human immunodeficiency virus that causes AIDS. Included are CD4 ANTIGENS, found on T4 lymphocytes, and monocytes/macrophages, which bind to the HIV ENVELOPE PROTEIN GP120.


Neutrophilic Leukemia, Chronic
Leukemia, Neutrophilic, Chronic

A rare myeloproliferative disorder that is characterized by a sustained, mature neutrophilic leukocytosis. No monocytosis, EOSINOPHILIA, or basophilia is present, nor is there a PHILADELPHIA CHROMOSOME or bcr-abl fusion gene (GENES, ABL).


Gene-Environment Interaction
Environment-Gene Interaction

The combined effects of genotypes and environmental factors together on phenotypic characteristics.


Valine Dehydrogenase (NADP+)
Valine Dehydrogenase, NADP-Dependent

An amino acid oxidoreductase that catalyzes the oxidative hydroxylation of L-VALINE to 3-methyl-2-oxobutanoate and AMMONIA in the presence of NADP.


Gonadal Dysgenesis, Mixed
Mixed Gonadal Dysgenesis

A type of defective gonadal development in patients with a wide spectrum of chromosomal mosaic variants. Their karyotypes are of partial sex chromosome monosomy resulting from an absence or an abnormal second sex chromosome (X or Y). Karyotypes include 45,X/46,XX; 45,X/46,XX/47,XXX; 46,XXp-; 45,X/46,XY; 45,X/47,XYY; 46,XYpi; etc. The spectrum of phenotypes may range from phenotypic female to phenotypic male including variations in gonads and internal and external genitalia, depending on the ratio in each gonad of 45,X primordial germ cells to those with normal 46,XX or 46,XY constitution.


Hemophilus pertussis
Haemophilus pertussis
Bordetella pertussis

A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.


Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.


MOPET
Methoxyhydroxyphenylethanol
Hydroxymethoxyphenethyl Alcohol
MHPE
3-Methoxy-4-hydroxyphenylethanol

Metabolite of serotonin and norepinephrine.


Labial Frenulum
Maxillary Labial Frenum
Labial Frenum

ORAL MUCOSA that connect the GINGIVA to the midline of the upper or lower lips.


The period of the CELL CYCLE following DNA synthesis (S PHASE) and preceding M PHASE (cell division phase). The CHROMOSOMES are tetraploid in this point.


Vocal Cord Dysfunction
Exercise-Induced Vocal Cord Dysfunction
Paradoxical Vocal Fold Motion Disorder
Paradoxical Vocal Fold Motion

A disorder characterized by an intermittent abnormal VOCAL CORDS movement toward the midline during inspiration or expiration resulting in upper AIRWAY OBSTRUCTION.


Cavovarus Foot Deformity
Talipes Cavus
Cavus Foot
High-Arched Foot
Pes Cavus
Cavus Deformity

A foot deformity in which the arch of the foot is high and often the heel adducted.


Deoxyribonucleic acid that makes up the genetic material of helminths.


cis-Flupenthixol alpha-Flupenthixol Emergil Flupenthixol Flupentixol Fluanxol

A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)


Gliptins
Dipeptidyl-Peptidase IV Inhibitors
Dipeptidyl-Peptidase 4 Inhibitors

Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release.


Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.


Biology, Developmental
Developmental Biology
Auxology


A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.


Porphobilinogen Ammonia-Lyase
Porphobilinogen Deaminase
Preuroporphyrinogen Synthetase
Hydroxymethylbilane Synthetase
Uroporphyrinogen I Synthase
Pre-uroporphyrinogen Synthetase
Hydroxymethylbilane Synthase

An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen (UROPORPHYRINOGENS) in several discrete steps. It is the third enzyme in the 8-enzyme biosynthetic pathway of HEME. In humans, deficiency in this enzyme encoded by HMBS (or PBGD) gene results in a form of neurological porphyria (PORPHYRIA, ACUTE INTERMITTENT). This enzyme was formerly listed as EC 4.3.1.8


Pyruvate Dehydrogenase (Lipoamide) Kinase

Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase

Pyruvate Dehydrogenase Acetyl-Transferring Kinase

A pyruvate dehydrogenase kinase isozyme located in the mitochondria which converts PYRUVATE to ACETYL CoA in the CITRIC ACID CYCLE, phosphorylates SERINE residues on pyruvate dehydrogenase using ATP, and plays a key role in the regulation of GLUCOSE and fatty acid metabolism.


Eosinophil Protein X
Serum Eosinophil Protein X
s-EPX
Eosinophil-Derived Neurotoxin
RNS2 Neurotoxin

A 19-kDa cationic peptide found in EOSINOPHIL granules. Eosinophil-derived neurotoxin is a RIBONUCLEASE and may play a role as an endogenous antiviral agent.


Elastase
Pancreatic Elastase
Pancreatopeptidase
Elastase I
Pancreatic Elastase I

A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.


Met(5)-Enkephalin
Methionine Enkephalin
Met-Enkephalin
5-Methionine Enkephalin
Enkephalin, Methionine

One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.


Eukaryotes in the group STRAMENOPILES, formerly considered FUNGI, whose exact taxonomic level is unsettled. Many consider Oomycetes (Oomycota) a phylum in the kingdom Stramenopila, or alternatively, as Pseudofungi in the phylum Heterokonta of the kingdom Chromista. They are morphologically similar to fungi but have no close phylogenetic relationship to them. Oomycetes are found in both fresh and salt water as well as in terrestrial environments. (Alexopoulos et al., Introductory Mycology, 4th ed, pp683-4). They produce flagellated, actively motile spores (zoospores) that are pathogenic to many crop plants and FISHES.


Increased Gravity
High Gravity
Hypergravity

Condition wherein the force of gravity is greater than or is increased above that on the surface of the earth. This is expressed as being greater than 1 g.


Physiologically active prostaglandins found in many tissues and organs. They show pressor activity, are mediators of inflammation, and have potential antithrombotic effects.


Ubiquitin-Related Modifier Protein, Small

Small Ubiquitin-Related Modifier Proteins

A class of structurally related proteins of 12-20 kDa in size. They covalently modify specific proteins in a manner analogous to UBIQUITIN.


Chemokine (C-X-C Motif) Ligand 9 Protein

Monokine Induced by gamma Interferon Chemokine

An INTEFERON-inducible CXC chemokine that is specific for the CXCR3 RECEPTOR.


Central Nervous System Hereditary Demyelinating Diseases

Central Nervous System Demyelinating Diseases, Hereditary

Demyelinating Central Nervous System Diseases, Hereditary

Hereditary Central Nervous System Demyelinating Diseases

Central Nervous System Demyelinating Hereditary Diseases

Demyelinating Diseases, Central Nervous System, Hereditary

Hereditary Demyelinating Diseases, Central Nervous System

Inherited conditions characterized by a loss of MYELIN in the central nervous system.


Duplication, Chromosome
Chromosomal Duplication
Duplication, Chromosomal
Chromosome Duplication

An aberration in which an extra chromosome or a chromosomal segment is made.


A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)


Canine Guidance
Occlusion, Dental
Occlusal Guidance
Dental Occlusion
Occlusal Plane

The relationship of all the components of the masticatory system in normal function. It has special reference to the position and contact of the maxillary and mandibular teeth for the highest efficiency during the excursive movements of the jaw that are essential for mastication. (From Jablonski, Dictionary of Dentistry, 1992, p556, p472)


A plant genus of the family ROSACEAE. Members contain esculetin and QUERCETIN.


Fluorescent Agents
Fluorochromes
Fluorescent Probes
Fluorescence Agents
Fluorescent Dyes
Fluorogenic Substrate

Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.


An inflammatory process with loss of supporting bone in the tissues surrounding functioning DENTAL IMPLANTS.


A chemically diverse group of substances produced by various tissues in the body that cause slow contraction of smooth muscle; they have other intense but varied pharmacologic activities.


LeVeen Shunt
Ascites Shunt, Peritoneovenous
Peritoneo-Venous Shunt
Peritoneovenous Shunt

An operation for the continuous emptying of ascitic fluid into the venous system. Fluid removal is based on intraperitoneal and intrathoracic superior vena cava pressure differentials and is performed via a pressure-sensitive one-way valve connected to a tube traversing the subcutaneous tissue of the chest wall to the neck where it enters the internal jugular vein and terminates in the superior vena cava. It is used in the treatment of intractable ascites.


Bone Marrow Failure Syndromes
Bone Marrow Failure
Bone Marrow Failure Disorders

Inherited or acquired diseases characterized by insufficient and/or dysplastic blood cells.


CBFalpha Runt Domain Transcription Factor 1

A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.


Femoral Neck Fractures
Femur Neck Fractures

Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.


Malformations of Cortical Development, Group II

Malformations Secondary to Abnormal Neuronal Migration

Malformations Due to Abnormal Neuronal Migration

Cortical malformations secondary to abnormal neuronal CELL MIGRATION in NEUROGENESIS. This group includes COBBLESTONE LISSENCEPHALY and PERIVENTRICULAR NODULAR HETEROTOPIA.


vpr Protein, Human Immunodeficiency Virus

vpr Gene Products, Human Immunodeficiency Virus

Proteins encoded by the VPR GENES of the HUMAN IMMUNODEFICIENCY VIRUS.


A heterogeneous-nuclear ribonucleoprotein that has specificity for AU-rich elements found in the 3'-region of mRNA and may play a role in RNA stability. Several isoforms of hnRNP D protein have been found to occur due to alternative mRNA splicing (RNA SPLICING).


The pectoralis major and pectoralis minor muscles that make up the upper and fore part of the chest in front of the AXILLA.


Bacterial Infection
Bacterial Infections
Infection, Bacterial
Infections, Bacterial

Infections by bacteria, general or unspecified.


Morton's Metatarsalgia
Intermetatarsal Neuroma
Morton's Neuralgia
Morton Neuroma
Morton's Neuroma
Morton's Disease

A nerve inflammation in the foot caused by chronic compression of the plantar nerve between the METATARSAL BONES.


Megakaryocyte Growth and Development Factor

Myeloproliferative Leukemia Virus Oncogene Ligand

A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.


Weber-Christian Disease
Panniculitis, Nodular Nonsuppurative

A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. They normally resolve, but tend to leave depressions in the skin. The condition is most often seen in women, alone or in association with other disorders.


Dysphasia, Broca's
Aphasia, Ataxic
Aphasia, Motor
Agrammatic Broca's Aphasia
Dysphasia, Broca
Aphasia, Anterior
Broca Aphasia
Agrammatism
Agrammatic Broca Aphasia
Aphasia, Broca
Aphasia, Nonfluent
Verbal Aphasia Syndrome
Aphasia, Expressive
Aphasia, Frontocortical

An aphasia characterized by impairment of expressive LANGUAGE (speech, writing, signs) and relative preservation of receptive language abilities (i.e., comprehension). This condition is caused by lesions of the motor association cortex in the FRONTAL LOBE (BROCA AREA and adjacent cortical and white matter regions).


Bruton's Tyrosine Kinase
Agammaglobulinaemia Tyrosine Kinase
B Cell Progenitor Kinase

A non-receptor tyrosine kinase that is essential for the development, maturation, and signaling of B-LYMPHOCYTES. It contains an N-terminal zinc finger motif and localizes primarily to the PLASMA MEMBRANE and nucleus of B-lymphocytes. Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA.


Mersalyl Acid
Mercusal
Salyrgan
Mersalyl
Mersalin
Mercuramide

A toxic thiol mercury salt formerly used as a diuretic. It inhibits various biochemical functions, especially in mitochondria, and is used to study those functions.


Orf Virus Infection
Contagious Pustular Dermatitis
Dermatitis, Contagious Pustular
Ecthyma, Contagious

An infectious dermatitis of sheep and goats, affecting primarily the muzzle and lips. It is caused by a poxvirus and may be transmitted to man.


Protein-mineral complexes that comprise substrates needed for the normal calcium-carbonate-phosphate homeostasis. Nanobacteria was the prior name for the particles which were originally thought to be microorganisms.


Government, State
Provincial Government
State Government

The level of governmental organization and function below that of the national or country-wide government.


Phagocyte
Phagocytes
Phagocytic Cell
Phagocytic Cells

Cells that can carry out the process of PHAGOCYTOSIS.


Immune Complex Diseases
Hypersensitivity, Type III
Type III Hypersensitivity

Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.


Follicle Stimulating Hormone, beta Polypeptide Chain

Follicle-Stimulating Hormone, beta Subunit

Follicle Stimulating Hormone, beta Subunit

The beta subunit of follicle stimulating hormone. It is a 15-kDa glycopolypeptide. Full biological activity of FSH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the FSHB gene causes delayed puberty, or infertility.


Oil derived from the seeds of SUNFLOWER plant, Helianthus.


A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.


Medial Tibial Stress Syndrome
Medial Tibial Stress Syndrome (MTSS)
Shin Splints

SKELETAL MUSCLE pain and tenderness along the posteromedial TIBIA resulting from exercise such as running and other physical activity.


Infection of the FRONTAL BONE often as a complication of FRONTAL SINUSITIS or trauma to the frontal bone and skull. It is characterized by subperiosteal abscess with OSTEOMYELITIS.


A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins.


A 69-amino acid peptide derived from the N-terminal of PROGLUCAGON. It is mainly produced by the INTESTINAL L CELLS. Further processing of glicentin yield a 30-amino acid N-terminal peptide (glicentin-related polypeptide) and a 37-amino acid peptide OXYNTOMODULIN. Both glicentin and oxyntomodulin can reduce digestive secretions and delay gastric emptying.


Astrobiology
Exobiology
Extraterrestrial Life
Space Biology

The interdisciplinary science that studies evolutionary biology, including the origin and evolution of the major elements required for life, their processing in the interstellar medium and in protostellar systems. This field also includes the study of chemical evolution and the subsequent interactions between evolving biota and planetary evolution as well as the field of biology that deals with the study of extraterrestrial life.


An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.


Prostacyclin Dehydrogenase
Hydroxyprostaglandin Dehydrogenase
Hydroxyprostaglandin Dehydrogenases

Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.


ATF6 Transcription Factor
Activating Transcription Factor 6

One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.


Enhancer of Zeste Homolog 2
Lysine N-Methyltransferase-6
Enhancer of Zeste Homolog 2 Protein
Histone-Lysine N-Methyltransferase EZH2

A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2.  It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.


Melanoma, Malignant, of Soft Parts
Malignant Melanoma of Soft Parts
Melanoma of Soft Parts
Sarcoma, Clear Cell
Clear Cell Sarcoma of Soft Tissue

A sarcoma of young adults occurring in the lower extremities and acral regions. It is found intimately bound to tendons as a circumscribed but unencapsulated melanin-bearing tumor of neuroectodermal origin. Clear cell sarcoma is associated with a specific t(12;22)(q13;q12) translocation.


CD3 Complex
CD3 Antigen
T3 Antigen
Antigens, CD3
T3 Antigens
CD3 Antigens
T3 Complex

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).


An order of mostly marine CRUSTACEA containing more than 5500 species in over 100 families. Like ISOPODA, the other large order in the superorder Peracarida, members are shrimp-like in appearance, have sessile compound eyes, and no carapace. But unlike Isopoda, they possess thoracic gills and their bodies are laterally compressed.


Lysyl Oxidase
Collagen Lysyl Oxidase
Protein-Lysine 6-Oxidase

An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.


Subjective Health
Diagnostic Self Evaluation
Subjective Health Complaint
Self-Appraisal
Self-Evaluation

Process by individual in valuation of specific traits, qualities, or abilities related to the individual.


A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)


Hypopharyngeal Cancer
Neoplasms, Hypopharyngeal
Hypopharyngeal Neoplasms


Palmar Plate
Volar Plate, Thumb
Volar Plate, Metacarpophalangeal
Metacarpophalangeal Volar Plate
Volar Plate, Finger

A thick, fibrocartilaginous ligament at the METACARPOPHALANGEAL JOINT of the hand.


Hemorrhage, Biliary Tract
Hemobilia
Biliary Tract Hemorrhage

Hemorrhage in or through the BILIARY TRACT due to trauma, inflammation, CHOLELITHIASIS, vascular disease, or neoplasms.


Heat Stress Disorders
Stress Disorders, Heat
Heat Cramps
Heat Stress Syndromes

A group of conditions that develop due to overexposure or overexertion in excessive environmental heat.


Chain Initiation, Peptide, Translational

A process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis.


One-Carbon Group Transferases
Single-Carbon Group Transferases

A subclass of transferases that transfer chemical groups containing a single carbon. These include the METHYLTRANSFERASES, the HYDROXYMETHYL AND FORMYL TRANSFERASES, the CARBOXYL AND CARBAMOYL TRANSFERASES, and the AMIDINOTRANSFERASES. EC 2.1.


Acidosis, Respiratory
Respiratory Acidosis

Respiratory retention of carbon dioxide. It may be chronic or acute.


Livedo-like Dermatitis
Nicolau's Livedoid Syndrome
Embolia Cutis Medicamentosa
Nicolau Livedoid Dermatitis
Nicolau Syndrome
Nicolau's Syndrome

An uncommon complication of INTRAMUSCULAR INJECTION leading to variable degrees of necrosis of skin and underlying tissue.


Ceporin Cephalomycine Cefaloridine Cephaloridine Cephaloridin


LY-121860 para-Chloroamphetamine p-Chloramphetamine Ly-123362 p-Chloroamphetamine Parachloroamphetamine

Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.


Health Level Seven (Organization)
Health Level 7
Health Level Seven

An American National Standards Institute-accredited organization working on specifications to support development and advancement of clinical and administrative standards for healthcare.


LAMP2 Protein
CD107b Antigens
Lysosomal-Associated Membrane Protein 2
Antigens, CD107b
LGP-B Protein
LGP110 Protein
CD107b Antigen

An abundant lysosomal-associated membrane protein that has been found to shuttle between LYSOSOMES; ENDOSOMES; and the PLASMA MEMBRANE. Loss of expression of lysosomal-associated membrane protein 2 is associated with GLYCOGEN STORAGE DISEASE TYPE IIB.


Mice, Inbred mdx
Mice, mdx
Mouse, Inbred mdx
Mouse, mdx

A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.


Diffuse Tenosynovial Giant Cell Tumor
Synovitis, Pigmented Villonodular

Diffuse outgrowth arising from the SYNOVIAL MEMBRANE; SYNOVIAL BURSA; or TENDON sheath around the joint cavity, with extension to surrounding soft tissue. It is characterized by pigmented HEMOSIDERIN-containing MACROPHAGES; FOAM CELLS; and multinucleated GIANT CELLS. It usually occurs in the hands and feet, and around large joints, such as in the ankle and knee joints.


A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. They are evergreen, pyramidal trees with whorled branches and thin, scaly bark. Each of the linear, spirally arranged leaves are joined near the stem on a separate woody base.


Anterior Perforated Space
Anterior Perforated Substance
Tuberculum Olfactorium
Olfactory Tubercle

Region in the ventral TELENCEPHALON located anterior to the OPTIC CHIASM, posterior to the OLFACTORY PEDUNCLE, rostral to the PIRIFORM AREA and ventral to the NUCLEUS ACCUMBENS.


Sucrose, Dietary
Table Sugar
Dietary Sucrose

Sucrose present in the diet. It is added to food and drinks as a sweetener.


One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.


Thin layer of WHITE MATTER mostly of GABAERGIC NEURONS located between the PUTAMEN and the CLAUSTRUM.


Temperate Rainforest
Rain Forest
Rainforest
Tropical Rainforest

Forests with high average annual rainfall.


Hexadecanoic Acid
Sodium Palmitate
Palmitic Acid
Calcium Palmitate

A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.


Indians, Central American
Amerinds, Central American

Individual members of Central American ethnic groups with ancient historic ancestral origins in Asia. Mexican Indians are not included.


Simian foamy virus
Human Spumavirus
Human foamy virus
Chimpanzee foamy virus human isolate
Chimpanzee foamy virus

A species of SPUMAVIRUS causing non-pathogenic infections in chimpanzees and humans.


p97MAPK Protein
MAPK6 Mitogen-Activated Protein Kinase
p97(MAPK) Protein
ERK3 Kinase
Extracellular Signal-Regulated Kinase 3
Mitogen-Activated Protein Kinase 6

A 97-kDa extracellular signal-regulated MAP kinase. Mitogen-activated protein kinase 6 levels increase during cellular differentiation, while in proliferating cells the enzyme is degraded rapidly via the PROTEASOME ENDOPEPTIDASE COMPLEX.


Voltage-Gated Sodium Channel Antagonists

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.


Ornithine-8-Vasopressin
Ornithine Vasopressin
Vasopressin, Ornithine
Ornipressin
POR-8
Orpressin

A synthetic analog of vasopressin with ORNITHINE substitution at residue 8 of the cyclic nonapeptide. It is used as a local vasoconstrictor and hemostatic.


Mesenteric Duodenal Compression Syndrome

Duodenal Compression Syndrome, Mesenteric

DUODENAL OBSTRUCTION by the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) which travels in the root of the MESENTERY and crosses over the DUODENUM. The syndrome is characterized by the dilated proximal duodenum and STOMACH, bloating, ABDOMINAL CRAMPS, and VOMITING. Often it is observed in patient with body casts after spinal surgery.


Salvage Therapy
Therapy, Salvage
Salvage Treatment

A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.


The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.


Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.


Circadian Locomotor Output Cycles Kaput Proteins

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.


Chemoreceptor Cells
Chemoreceptive Cells

Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.


Haemophilus influenzae
Hemophilus influenzae

A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.


Tumor Necrosis Factor Receptor Superfamily, Member 5

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)


Tumor Necrosis Factor Receptor Superfamily, Member 25

Receptors, Tumor Necrosis Factor, Member 25

Lymphocyte Associated Receptor of Death Protein

A tumor necrosis factor receptor subtype with specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15. It is found in tissues containing LYMPHOCYTES and may play a role in regulating lymphocyte homeostasis and APOPTOSIS. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.


One of the largest orders of mostly marine CRUSTACEA, containing over 10,000 species. Like AMPHIPODA, the other large order in the superorder Peracarida, members are shrimp-like in appearance, have sessile compound eyes, and no carapace. But unlike Amphipoda, they possess abdominal pleopods (modified as gills) and their bodies are dorsoventrally flattened.


Amino Acyl tRNA
Amino Acyl T RNA
Transfer RNA, Amino Acyl
RNA, Transfer, Amino Acyl
tRNA-Amino Acyl

Intermediates in protein biosynthesis. The compounds are formed from amino acids, ATP and transfer RNA, a reaction catalyzed by aminoacyl tRNA synthetase. They are key compounds in the genetic translation process.


Thiamin Triphosphate
Thiamine Triphosphate

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,8,8-tetrahydroxy-3,5,7-trioxa-4,6,8-triphosphaoct-1-yl)thiazolium hydroxide, inner salt, P,P',P''-trioxide. The triphosphate ester of thiamine. In Leigh's disease, this compound is present in decreased amounts in the brain due to a metabolic block in its formation.


A fine channel that passes through the TEMPORAL BONE near the SCALA TYMPANI (the basilar turn of the cochlea). The cochlear aqueduct connects the PERILYMPH-filled bony labyrinth to the SUBARACHNOID SPACE.


Factor Seven A
Coagulation Factor VIIa
Factor VIIa
Blood Coagulation Factor VII, Activated
Factor VII, Activated
Factor 7A

Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.


Rectal Palpation
Digital Rectal Examination

A physical examination in which the qualified health care worker inserts a lubricated, gloved finger of one hand into the RECTUM and may use the other hand to press on the lower ABDOMEN or pelvic area to palpate for abnormalities in the lower rectum, and nearby organs or tissues. The method is commonly used to check the lower rectum, the PROSTATE gland in men, and the UTERUS and OVARIES in women.


Intracranial Central Nervous System Disorders

Central Nervous System Intracranial Disorders

Central Nervous System Disorders, Intracranial

Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.


Proteins obtained from species of BIRDS.


Giardia duodenalis Infection
Giardiasis
Giardia Infection
Giardia lamblia Infection
Lambliasis
Giardia intestinalis Infection

An infection of the SMALL INTESTINE caused by the flagellated protozoan GIARDIA. It is spread via contaminated food and water and by direct person-to-person contact.


Tyrosyl-tRNA Synthetase
Tyrosine-tRNA Ligase
Tyrosyl T RNA Synthetase
Tyr-tRNA Ligase

An enzyme that activates tyrosine with its specific transfer RNA. EC 6.1.1.1.


NaSi-1 Cotransporter
Sodium Sulfate Cotransporter
NaS1 Sulfate Transporter
Slc13a1 Protein
Na(+)-SO4(2-) Cotransporter

A multi-pass protein that consists of 13 transmembrane helices. It is expressed primarily by renal epithelial cells and functions as a co-transporter of sodium and sulfate, to mediate sulfate reabsorption in the kidney.


Kirsten murine sarcoma virus
Kirsten Sarcoma Virus

A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) capable of transforming mouse lymphoid cells and producing erythroid leukemia after superinfection with murine leukemia viruses (LEUKEMIA VIRUS, MURINE). It has also been found to transform cultured human fibroblasts, rat liver epithelial cells, and rat adrenocortical cells.


Phakic Intraocular Lenses
Phakic Intraocular Lens
Lens, Intraocular, Phakic

Lenses, generally made of plastic or silicone, that are implanted into the eye in front of the natural EYE LENS, by the IRIS, to improve VISION, OCULAR. These intraocular lenses are used to supplement the natural lens instead of replacing it.


Technetium Tc 99m Sulfur Colloid
Tc 99m Sulfur Colloid
Tc-99m Sulfur Colloid
Technetium Sulfur Colloid
Lymphoszint

A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.


Neoplasm Vaccines
Vaccines, Tumor
Vaccines, Neoplasm
Cancer Vaccines
Vaccines, Cancer
Tumor Vaccines

Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.


Damages to the EMBRYO, MAMMALIAN or the FETUS before BIRTH. Damages can be caused by any factors including biological, chemical, or physical.


A photoprotein isolated from the bioluminescent jellyfish Aequorea. It emits visible light by an intramolecular reaction when a trace amount of calcium ion is added. The light-emitting moiety in the bioluminescence reaction is believed to be 2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine (AF-350).


PAR1 Receptor
Proteinase-Activated Receptor 1
Receptor, PAR-1
Protease-Activated Receptor 1
PAR-1 Receptor

A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.


Hu Paraneoplastic Encephalomyelitis Antigens

Embryonic Lethal, Abnormal Vision-Like Proteins

A family of RRM PROTEINS that are homologues of ELAV protein, Drosophila. They were initially identified in humans as the targets of autoantibodies in patients with PARANEOPLASTIC ENCEPHALOMYELITIS. They regulate GENE EXPRESSION at the post-transcriptional level.


A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.


TFIII Transcription Factors
Transcription Factors, TFIII

Factors that bind to RNA POLYMERASE III and aid in transcription. They include the assembly factors TFIIIA and TFIIIC and the initiation factor TFIIIB. All combine to form a preinitiation complex at the promotor that directs the binding of RNA POLYMERASE III.


Extraintestinal Pathogenic Escherichia coli

Strains of Escherichia coli that possess virulence traits which allow them to invade, colonize, and induce disease in tissues outside of the GASTROINTESTINAL TRACT. They are a cause of URINARY TRACT INFECTIONS (UROPATHOGENIC ESCHERICHIA COLI); neonatal MENINGITIS; SEPSIS; PNEUMONIA; and SURGICAL WOUND INFECTION.


Sodium-Independent Organic Anion Transporters

Organic Anion Transporters, Sodium-Independent

A subclass of ORGANIC ANION TRANSPORTERS that do not rely directly or indirectly upon sodium ion gradients for the transport of organic ions.


Neurodegeneration With Brain Iron Accumulation 1

Neurodegeneration with Brain Iron Accumulation Type 1

PKAN Neuroaxonal Dystrophy, Juvenile-Onset

A rare autosomal recessive degenerative disorder which usually presents in late childhood or adolescence. Clinical manifestations include progressive MUSCLE SPASTICITY; hyperreflexia; MUSCLE RIGIDITY; DYSTONIA; DYSARTHRIA; and intellectual deterioration which progresses to severe dementia over several years. (From Adams et al., Principles of Neurology, 6th ed, p972; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp972-929)


Tapetochoroidal Dystrophy, Progressive
Choroideremia
Progressive Tapetochoroidal Dystrophy

An X chromosome-linked abnormality characterized by atrophy of the choroid and degeneration of the retinal pigment epithelium causing night blindness.


Adenylosuccinate Synthase
Adenylosuccinate Synthetase
Succino-AMP Synthetase

A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.


Patient Education as Topic
Education of Patients
Education, Patient

The teaching or training of patients concerning their own health needs.


Spiking Mortality Syndrome
Poult Enteritis Mortality Syndrome

An acute, transmissible, infectious disease associated with high MORTALITY and MORBIDITY in young turkeys (poults). It is characterized by DIARRHEA; ANOREXIA; growth depression, and immune dysfunction. The cause is unknown but astroviruses (AVASTROVIRUS) and coronaviruses (CORONAVIRUS, TURKEY) have been isolated from diseased poults and are thought to cause the enteritis and increased susceptibility to bacterial infections.


Hepatic Veno-Occlusive Disease
Hepatic Veno Occlusive Disease
Veno-Occlusive Disease, Hepatic
Sinusoidal Obstruction Syndrome

Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.


Mercy Killing, Animal
Euthanasia, Animal
Animal Euthanasia

The killing of animals for reasons of mercy, to control disease transmission or maintain the health of animal populations, or for experimental purposes (ANIMAL EXPERIMENTATION).


Recording serial images of a process at regular intervals spaced out over a longer period of time than the time in which the recordings will be played back.


Anthocidaris crassispina
Anthocidaris
Heliocidaris


Depiction of scientific issues or themes via the arts including visual, oral, or written forms of expression.


An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.


A common chronic, noninflammatory and usually symptomless disorder, characterized by the occurrence of multiple macular patches of all sizes and shapes, and varying in pigmentation from fawn-colored to brown. It is seen most frequently in hot, humid, tropical regions, and is caused by Pityrosporon orbiculare. (Dorland, 27th ed)


Kaplan-Meier Test
Product-Limit Method
Kaplan-Meier Survival Curves
Kaplan-Meier Estimate
Kaplan-Meier Analysis

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)


Glomus Jugulare Tumor
Glomus Tumors, Familial, 1
Glomus Jugulare Tumors

A paraganglioma involving the glomus jugulare, a microscopic collection of chemoreceptor tissue in the adventitia of the bulb of the jugular vein. It may cause paralysis of the vocal cords, attacks of dizziness, blackouts, and nystagmus. It is not resectable but radiation therapy is effective. It regresses slowly, but permanent control is regularly achieved. (From Dorland, 27th ed; Stedman, 25th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1603-4)


Radioactivity
Radioactive Disintegration
Nuclear Decay

The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


Angina, Preinfarction
Myocardial Preinfarction Syndrome
Unstable Angina
Angina at Rest
Angina, Unstable
Angina Pectoris, Unstable

Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.


Anterior Horn Neurons
Ventral Horn Cells
Anterior Horn Cells
Ventral Horn Neurons
Neurons, Ventral Horn
Neurons, Anterior Horn

MOTOR NEURONS in the anterior (ventral) horn of the SPINAL CORD which project to SKELETAL MUSCLES.


Inflammation of the connective and adipose tissues surrounding the KIDNEY.


A genus of poisonous snakes of the subfamily Elapinae of the family ELAPIDAE. They comprise the kraits. Twelve species are recognized and all inhabit southeast Asia. They are considered extremely dangerous. (Moore: Poisonous Snakes of the World, 1980, p120)


The practice of dentistry as applied to special circumstances associated with military operations.


Post-gamma-Globulin
Cystatin C
gamma-Trace
Neuroendocrine Basic Polypeptide
Cystatin 3

An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.


DNA-Dependent DNA Polymerase I
Klenow Fragment
DNA Polymerase alpha
DNA Polymerase I
DNA Pol I

A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.


Fursemide
Furantral
Frusemide
Furosemide Monosodium Salt
Fusid
Frusemid
Lasix
Furosemide Monohydrochloride
Furosemide
Furanthril
Errolon

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.


Beating Heart Coronary Artery Bypass
Coronary Artery Bypass, Off-Pump
Coronary Artery Bypass, Beating Heart
Off-Pump Coronary Artery Bypass

Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).


Microtomy
Ultramicrotomy
Thin Sectioning

The technique of using a microtome to cut thin or ultrathin sections of tissues embedded in a supporting substance. The microtome is an instrument that hold a steel, glass or diamond knife in clamps at an angle to the blocks of prepared tissues, which it cuts in sections of equal thickness.


mRNA Differential Display
Gene Expression Profiling
Gene Expression Pattern Analysis
Transcriptome Profiling
Transcriptome Analysis
Transcript Expression Analysis
Gene Expression Monitoring

Analysis of differentially expressed RNA transcripts from different tissues, cells, strains, or conditions.


Activation of Amino Acids
Amino Acylation
Aminoacylation

A reaction that produces an "activated" amino acid derivative, such as amino acyl adenylate, or amino acylphosphorylate and provides energy for the amino acid to be incorporated into a peptide, protein, or other macromolecule.


Ethyl Mercury Compounds
Ethylmercury Compounds
Ethylmercurials

Organic mercury compounds in which the mercury is attached to an ethyl group.


Muscle Fibers, Fast-Twitch
Muscle Fibers, White
Muscle Fibers, Intermediate
Muscle Fibers, Type II

Skeletal muscle fibers characterized by their expression of the Type II MYOSIN HEAVY CHAIN isoforms which have high ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment. Several fast types have been identified.


Opisthorchis felineus Infection
Opisthorchiasis
Opisthorchis viverrini Infection
Opisthorchis Infection

Infection with flukes of the genus Opisthorchis.


Deoxyribozymes
DNAzymes
DNA, Catalytic
Catalytic DNA
Deoxyribozyme
DNAzyme

Molecules of DNA that possess enzymatic activity.


Xenoantigens
Antigens, Xenogeneic
H-D Antigens
Heterogenetic Antigens
Antigens, Heterophil
Heterophile Antigens
Heterologous Antigens
Antigens, Heterologous
Hanganutziu-Deicher Antigens
Paul-Bunnell Antigens
Heteroantigens
Antigens, Heterogenetic
Antigens, Xenogenic
Antigens, Heterophile

Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.


Antibodies, Immobilized
Immobilized Antibodies

Antibodies that are chemically bound to a substrate material which renders their location fixed.


Psychoses, Paranoid
Paranoid Psychoses
Paranoia
Paranoid Disorders

Chronic mental disorders in which there has been an insidious development of a permanent and unshakeable delusional system (persecutory delusions or delusions of jealousy), accompanied by preservation of clear and orderly thinking. Emotional responses and behavior are consistent with the delusional state.


Transferrin Receptors
Receptors, Transferrin
Transferrin Receptor

Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.


A family of hardbacked TICKS, in the subclass ACARI. Genera include DERMACENTOR and IXODES among others.


Mating Behavior, Animal
Sex Behavior, Animal
Sexual Behavior, Animal


A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.


ICI-55695
Methyl Clofenapate
Clofenapate
Methylclofenapate

An oral hypolipemic agent primarily used in DOGS and RATS.


NatC N-Terminal Acetyltransferase
N-Terminal Acetyltransferase C
N-Terminal Acetyltransferase Type C

An N-terminal acetyltransferase subtype that consists of the Naa30p catalytic subunit, and the Naa35p and Naa38p auxiliary subunits. It has specificity for the N-terminal METHIONINE of peptides where the next amino acid in the chain is either LEUCINE; PHENYALANINE; ISOLEUCINE; or TRYPTOPHANE.


Intrahepatic Cholangiocarcinoma
Cholangiocellular Carcinoma
Extrahepatic Cholangiocarcinoma
Cholangiocarcinoma

A carcinoma that originates in the intrahepatic bile duct epithelium of the intrahepatic biliary tree. Malignant lesions are solid, nodular, and grayish. Most cases are adenocarcinomas. Somatic mutations in BAP1, ARID1A, PBRM1, IDH1, and IDH2 genes have been identified. OMIM: 615619


Neoplasia, Prostatic Intraepithelial
Intraepithelial Prostatic Neoplasia
Prostatic Intraepithelial Neoplasms
Prostatic Intraepithelial Neoplasia

A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.


Hair grooming, cleansing and modifying products meant for topical application to hair, usually human. They include sprays, bleaches, dyes, conditioners, rinses, shampoos, nutrient lotions, etc.


CD4 Lymphocyte Count
CD4+ Counts
T4 Lymphocyte Count
CD4+ Cell Counts
Lymphocyte Count, CD4
CD4 Counts
CD4 Cell Counts

The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.


Mitogen-Activated Protein Kinase Kinase Kinase 1

A 195-kDa zinc finger motif-containing MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It localizes to the CYTOSKELETON and can activate a variety of MAP kinase-dependent pathways.


Tension Headache
Stress Headache
Tension-Vascular Headache
Idiopathic Headache
Headache, Tension
Tension-Type Headache
Psychogenic Headache

A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to moderate intensity in the HEAD; SCALP; or NECK. The subtypes are classified by frequency and severity of symptoms. There is no clear cause even though it has been associated with MUSCLE CONTRACTION and stress. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)


Crowdsourcing
Crowdsource
Crowd Sourcing

Results of data collected from Crowdsource collection.


A mass of tissue for transplantation that includes the skin and/or the SUBCUTANEOUS FAT, and the perforating blood vessel that traverses the underlying tissue to supply blood to the skin. Perforator flaps are named after the anatomical region or muscle from where they are transplanted and/or the perforating blood vessel.


A complex of ansamycin antibiotics consisting of streptovaricins A, B, C, D, E, F, G, J, and K of which streptovaricin C is the major component. (From Merck Index, 11th ed)


Sodium Glutamate
Accent
MSG
Vestin
Monosodium Glutamate

One of the FLAVORING AGENTS used to impart a meat-like flavor.


A plant genus of the family URTICACEAE. Members contain cryptopleurine, beta-sitosterol, daucosterol and 19 alpha-hydroxyursolic acid.


Inflammation of the NASAL MUCOSA in the FRONTAL SINUS. In many cases, it is caused by an infection of the bacteria STREPTOCOCCUS PNEUMONIAE or HAEMOPHILUS INFLUENZAE.


Colonic Urinary Reservoirs
Urinary Reservoirs, Continent
Continent Urinary Reservoirs

Structures which collect and store urine and are emptied by catheterization of a cutaneous stoma or internal diversion to the urethra. The reservoirs are surgically created during procedures for urinary diversion.


CC Chemokine Receptor 4
CC Chemokine Receptors 4
Receptors, CCR4
CD194 Antigens
CD194 Antigen
CCR4 Receptors
CCR4 Receptor
Antigens, CD194

CCR receptors with specificity for CHEMOKINE CCL17 and CHEMOKINE CCL22. They are expressed at high levels in T-LYMPHOCYTES; MAST CELLS; DENDRITIC CELLS; and NK CELLS.


Radiation Monitoring
Monitoring, Radiation

The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.


Sexual Aversion Disorder
Hypoactive Sexual Desire Disorder
Psychosexual Disorders
Psychosexual Dysfunctions
Frigidity
Sexual Arousal Disorder
Orgasmic Disorder
Sexual Dysfunctions, Psychological

Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)


Hyperinsulinemia
Compensatory Hyperinsulinemia
Endogenous Hyperinsulinism
Exogenous Hyperinsulinism
Hyperinsulinism

A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.


HTATIP
KAT5 (TIP60) Protein
HIV-1-Tat Interactive Protein Tip60
Lysine Acetyltransferase 5

A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.


Central Core Disease of Muscle
Shy-Magee Syndrome
Myopathy, Central Core
Central Core Myopathy
Central Core Disease

An inherited congenital myopathic condition characterized by weakness and hypotonia in infancy and delayed motor development. Muscle biopsy reveals a condensation of myofibrils and myofibrillar material in the central portion of each muscle fiber. (Adams et al., Principles of Neurology, 6th ed, p1452)


Flaval Ligament
Ligamentum Flavum
Ligamenta Flava

The paired bands of yellow elastic tissue that connect adjoining laminae of the vertebrae. With the laminae, it forms the posterior wall of the spinal canal and helps hold the body erect.


Trypanosomatina Blastocrithidia Trypanosomatidae Herpetomonas Leptomonas

A suborder of monoflagellate parasitic protozoa that lives in the blood and tissues of man and animals. Representative genera include: Blastocrithidia, Leptomonas, CRITHIDIA, Herpetomonas, LEISHMANIA, Phytomonas, and TRYPANOSOMA. Species of this suborder may exist in two or more morphologic stages formerly named after genera exemplifying these forms - amastigote (LEISHMANIA), choanomastigote (CRITHIDIA), promastigote (Leptomonas), opisthomastigote (Herpetomonas), epimastigote (Blastocrithidia), and trypomastigote (TRYPANOSOMA).


Infraspinatus
Cuff, Rotator
Subscapularis
Rotator Cuff
Teres Minor
Supraspinatus

The musculotendinous sheath formed by the supraspinatus, infraspinatus, subscapularis, and teres minor muscles. These help stabilize the HUMERAL HEAD in the GLENOID CAVITY of the SCAPULA and allow for rotation of the SHOULDER JOINT about its longitudinal axis.


Calcium Fusarate
5-Butyl-2-pyridinedicarboxylic Acid
Fusaric Acid

A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.


Doppler Transcranial Sonography
Transcranial Doppler Sonography
Ultrasonography, Transcranial Doppler
Transcranial Sonography, Doppler
Sonography, Doppler Transcranial
Sonography, Transcranial Doppler
Doppler Ultrasonography, Transcranial
Ultrasonography, Doppler Transcranial
Transcranial Doppler Ultrasonography
Doppler Transcranial Ultrasonography
Transcranial Ultrasonography, Doppler
Neurosonology
Ultrasonography, Doppler, Transcranial
Doppler Sonography, Transcranial

A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.


Temporomandibular Joint Disk
Disk, Temporomandibular Joint
Articular Disc, Temporomandibular
Temporomandibular Joint Disc
Articular Disk, Temporomandibular

A plate of fibrous tissue that divides the temporomandibular joint into an upper and lower cavity. The disc is attached to the articular capsule and moves forward with the condyle in free opening and protrusion. (Boucher's Clinical Dental Terminology, 4th ed, p92)


Enzymes, Immobilized
Immobilized Enzymes

Enzymes which are immobilized on or in a variety of water-soluble or water-insoluble matrices with little or no loss of their catalytic activity. Since they can be reused continuously, immobilized enzymes have found wide application in the industrial, medical and research fields.


A nonspecific term used to denote any cutaneous lesion or group of lesions, or eruptions of any type on the leg. (From Stedman, 25th ed)


Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.


v-Rel Reticuloendotheliosis Viral Oncogene Homolog A

A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.


Uptake of substances through the nasal mucosa.


Renal Nursing
Urology Nursing
Nephrology Nursing
Urologic Nursing

A nursing specialty involving the care of patients with or at risk for KIDNEY DISEASES.


Enamel, Dental
Dental Enamel
Dental Enamels
Enamels, Dental
Enamel Cuticle
Enamel

A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)


Infections, Pneumovirus
Pneumovirus Infections

Infections with viruses of the genus PNEUMOVIRUS, family PARAMYXOVIRIDAE. This includes RESPIRATORY SYNCYTIAL VIRUS INFECTIONS, an important cause of respiratory disease in humans.


C1 Esterase
Complement 1s
C 1 Esterase
Complement C1s
C1s Complement
Complement Component 1s
Complement 1 Esterase

A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).


Phosphorylserine
Seryl Phosphate
Serine Phosphate
Phosphoserine


Acute-Phase Reaction
Acute-Phase State
Reaction, Acute-Phase
Response, Acute-Phase

An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.


Bypass, Coronary Artery
Bypass Surgery, Coronary Artery
Coronary Artery Bypass
Coronary Artery Bypass Grafting
Coronary Artery Bypass Surgery
Aortocoronary Bypass

Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.


Dictionaries, Pharmacy
Pharmaceutical Dictionary
Pharmacy Dictionary
Pharmacy Dictionaries
Dictionaries, Pharmaceutic as Topic
Dictionaries, Pharmacy as Topic
Pharmaceutical Dictionaries
Dictionary, Pharmacy

Works about specialized reference lists and descriptions of drugs and related concepts.


Potassium-Hydrogen Exchanger
Potassium-Hydrogen Antiporters
K(+)-H(+)-Exchanger
Potassium-Hydrogen Antiporter

Membrane proteins that allow the exchange of hydrogen ions for potassium ions across the cellular membrane. The action of these antiporters influences intracellular pH and potassium ion homeostasis.


Pyruvate Synthetase
Pyruvate Ferredoxin Oxidoreductase
Pyruvate-Ferredoxin Oxidoreductase
Pyruvate Oxidoreductase
Pyruvate Synthase

A ferredoxin-containing enzyme that catalyzes the COENZYME A-dependent oxidative decarboxylation of PYRUVATE to acetyl-COENZYME A and CARBON DIOXIDE.


Periapical Periodontitis
Periodontitis, Apical
Periodontitis, Acute Nonsuppurative

Inflammation of the PERIAPICAL TISSUE. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is PERIAPICAL GRANULOMA. Suppurative inflammation is PERIAPICAL ABSCESS.


Protozoan Encystation
Parasite Encystation
Parasite Encystment
Protozoan Parasite Encysment
Protozoan Parasite Encystation
Protozoan Encystment

Process by which certain parasites such as GIARDIA and ENTAMOEBA convert from the TROPHOZOITE to SCHIZONT when exposed to stress.


Topoisomerase 2 Inhibitors
DNA Type 2 Topoisomerase Inhibitors
Topoisomerase II Inhibitors
DNA Topoisomerase II Inhibitors
DNA Gyrase Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.


Formularies, Hospital as Topic
Hospital Formularies as Topic

Works about formularies concerned with PHARMACEUTICAL PREPARATIONS prescribed in hospitals.


Potassium Magnesium Asparaginate
Panangin
Potassium Magnesium Aspartate
Astra 2045
K-Mg Aspartate

An intra-extracellular electrolyte exchange agent with a variety of effects.


TNF and APOL-Related Leukocyte Expressed Ligand 1

Tumor Necrosis Factor Ligand Superfamily Member 13b

A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.


Hand, Foot and Mouth Disease
Hand, Foot, Mouth Disease

A mild, highly infectious viral disease of children, characterized by vesicular lesions in the mouth and on the hands and feet. It is caused by coxsackieviruses A.


Chicken Anemia Agent
Chicken anemia virus
Infectious Anemia Virus, Chicken
Chicken Infectious Anemia Virus

The type species of GYROVIRUS, a small, non-enveloped DNA virus originally isolated from contaminated vaccines in Japan. It causes chicken infectious anemia and may possibly play a key role in hemorrhagic anemia syndrome, anemia dermatitis, and blue wing disease.


Porcine enterovirus B
Enteroviruses, Porcine
Porcine enterovirus A
Porcine Enteroviruses

Species of ENTEROVIRUS causing mild to severe neurological diseases among pigs especially in Eastern Europe. Mild strains are also present in Canada, U.S., and Australia. Specific species include Porcine enterovirus A and Porcine enterovirus B.


Conditioned Culture Medium
Conditioned Media
Conditioned Medium
Conditioned Culture Media
Culture Medium, Conditioned
Culture Media, Conditioned

Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).


Aggregatibacter aphrophilus
Haemophilus aphrophilus

A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to oral cavity and pharynx. It is associated with BACTERIAL ENDOCARDITIS; and MENINGITIS.


A phylum of parasitic worms, closely related to tapeworms and containing two genera: Moniliformis, which sometimes infects man, and Macracanthorhynchus, which infects swine.


VEGI (Vascular Endothelial Growth Inhibitor) Protein

Tumor Necrosis Factor Ligand Superfamily Member 15

A member of tumor necrosis factor superfamily found on ENDOTHELIAL CELLS that plays a role in the inhibition of endothelial cell growth and PHYSIOLOGIC ANGIOGENESIS.


G(M3) Ganglioside
Sialyl Lactosylceramide
Ganglioside GM3
Hematoside
Sialyllactosylceramide
II3NeuAcLacCer

A ganglioside present in abnormally large amounts in the brain and liver due to a deficient biosynthetic enzyme, G(M3):UDP-N-acetylgalactosaminyltransferase. Deficiency of this enzyme prevents the formation of G(M2) ganglioside from G(M3) ganglioside and is the cause of an anabolic sphingolipidosis.


RPD3L1 Histone Deacetylase
HDAC1 Histone Deacetylase
Histone Deacetylase 1

A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 2; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.


Demon Possession
Spirit Possession
Demonic Possession

The idea that abnormal behavior or a medical condition is evidence that a person is under the control of a supernatural power or spirit. This belief was most commonly held in religion and medicine of the medieval period and is also held in many tribal cultures today.


Therapy, Reflex
Reflexotherapy
Reflex Therapy

Treatment of some morbid condition by producing a reflex action, as in the household treatment of nosebleed by a piece of ice applied to the cervical spine. (Stedman, 27th ed)


Groundnut Hypersensitivity
Allergy, Peanut
Hypersensitivity, Peanut
Peanut Hypersensitivity
Peanut Allergy

Allergic reaction to peanuts that is triggered by the immune system.


Schistosomiasis japonicum
Schistosoma japonicum Infection
Schistosomiasis japonica

Schistosomiasis caused by Schistosoma japonicum. It is endemic in the Far East and affects the bowel, liver, and spleen.


Polyamides Dermalon Polyamide Ethilon Nylons Supramid Nylon

Polymers where the main polymer chain comprises recurring amide groups. These compounds are generally formed from combinations of diamines, diacids, and amino acids and yield fibers, sheeting, or extruded forms used in textiles, gels, filters, sutures, contact lenses, and other biomaterials.


Carbamoyl-Phosphate Synthase (Ammonia) Activators

Carbamoyl Phosphate Synthetase I Activators

Substances and drugs that stimulate the synthesis or increase the activity of CARBAMOYL PHOSPHATE SYNTHETASE I. Drugs in this class of compounds have been used to treat the genetic disorder, CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY DISEASE.


A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.


T-Cell Receptor Genes
Genes, T-Cell Receptor
TcR Genes

DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. The TcR genes are formed by somatic rearrangement (see GENE REARRANGEMENT, T-LYMPHOCYTE and its children) of germline gene segments, and resemble Ig genes in their mechanisms of diversity generation and expression.


Phosphoprotein pp90
IP90 Protein
Integral Membrane Protein IP90
Calnexin

A lectin found in ENDOPLASMIC RETICULUM membranes that binds to specific N-linked OLIGOSACCHARIDES found on newly synthesized proteins. It may play role in PROTEIN FOLDING or retention and degradation of misfolded proteins in the endoplasmic reticulum.


Di Guglielmo Disease
Erythroblastic Leukemia, Acute
Leukemia, Erythroblastic, Acute
Di Guglielmo's Disease
Erythremic Myelosis
Myeloid Leukemia, Acute, M6
Leukemia, Myeloid, Acute, M6
Erythroleukemia

A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.


Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.


Depolarizing Muscle Relaxants
Muscle Relaxants, Depolarizing
Depolarizing Blockers
Neuromuscular Depolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation.


Differential Diagnosis
Diagnosis, Differential
Differential Diagnoses
Diagnoses, Differential

Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.


Trf2 Gene Product
Telomeric Repeat Binding Protein 2
TRBF2 Protein
TRF2 Protein
TERF2 Protein

A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues.


Laser-Assisted Stromal In Situ Keratomileusis

A surgical procedure to correct MYOPIA by CORNEAL STROMA subtraction. It involves the use of a microkeratome to make a lamellar dissection of the CORNEA creating a flap with intact CORNEAL EPITHELIUM. After the flap is lifted, the underlying midstroma is reshaped with an EXCIMER LASER and the flap is returned to its original position.


A family of snakes comprising the boas, anacondas, and pythons. They occupy a variety of habitats through the tropics and subtropics and are arboreal, aquatic or fossorial (burrowing). Some are oviparous, others ovoviviparous. Contrary to popular opinion, they do not crush the bones of their victims: their coils exert enough pressure to stop a prey's breathing, thus suffocating it. There are five subfamilies: Boinae, Bolyerinae, Erycinae, Pythoninae, and Tropidophiinae. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p315-320)


Transplantation Conditioning
Conditioning, Transplantation

Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.


A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.


Highbush Cranberry
Cramp Bark
Viburnum
Cranberry, Highbush

A plant genus in the family CAPRIFOLIACEAE. The common name derives from its traditional use for menstrual cramps. It is a source of viburnine, valerianic acid, vibsanin, and ursolic acid. Note that true cranberry is VACCINIUM MACROCARPON.


Injections, Intraperitoneal
Intraperitoneal Injections

Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.


Psychology, Industrial
Industrial Psychology

The branch of applied psychology concerned with the application of psychologic principles and methods to industrial problems including selection and training of workers, working conditions, etc.


CD129 Antigen
Interleukin-9 Receptors
IL-9 Receptors
Interleukin-9 Receptor
CD129 Antigens
Receptors, IL-9
IL-9 Receptor
Antigens, CD129
Receptors, Interleukin-9

A cell surface receptor that specifically mediates the biological effects of INTERLEUKIN-9. The functional IL9 receptor signals through interaction of its cytoplasm domain with JANUS KINASES and requires the INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT for activity.


Immunoglobulin Heavy Chain Subgroup VH-III

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.


Mechanosensing organelles of hair cells which respond to fluid motion or fluid pressure changes. They have various functions in many different animals, but are primarily used in hearing.


Zinc Finger Nucleases
Zinc-Finger Nucleases

Genetically engineered nucleases that cleave DNA at a defined distance from specific DNA sequences recognized by ZINC FINGER DNA-BINDING DOMAINS. They are composed of a DNA cleaving domain adapted from DNA endonucleases fused to a zinc finger DNA-binding domain.


Adrenergic beta-2 Receptor Agonist
Adrenergic beta-2 Receptor Agonists
Adrenergic beta-2 Agonists
Adrenergic beta2-Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.


A plant genus of the family ASTERACEAE. Members contain sesquiterpene lactones.


The number of mutations that occur in a specific sequence, GENE, or GENOME over a specified period of time such as years, CELL DIVISIONS, or generations.


Pongo abelii
Pongo pygmaeus abeli
Pongo pygmaeus abelii
Orangutan, Sumatran
Sumatran Orangutan

A species of orangutan, family HOMINIDAE, found in the forests on the island of Sumatra.


Anti-Oxidant Response Elements
Antioxidant Response Elements
Electrophile Response Elements

Nucleotide sequences that are found in the PROMOTER REGIONS of the genes of stress-responsive and cytoprotective proteins, such as those encoding antioxidant and PHASE II DETOXIFICATION enzymes. NF-E2-RELATED FACTOR 2 containing transcription factors bind to these elements during induction of these genes.


Gestational Pemphigoid
Pemphigoid Gestationis
Herpes Gestationis

An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).


Dry Macular Degeneration
Geographic Atrophy

A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.


Synthetic Prostaglandins
Prostaglandins, Synthetic
Prostaglandin Analogs
Prostaglandin Analogues
PG Analogs

Compounds obtained by chemical synthesis that are analogs or derivatives of naturally occurring prostaglandins and that have similar activity.


Acyl-CoA-Cholesterol Acyltransferase
Sterol O-Acyltransferase
Cholesterol Esterifying Enzyme
Cholesterol Acyltransferase

An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.


Host-Parasite Relationship
Host-Parasite Interactions
Parasite-Host Interactions
Parasite-Host Relations
Host-Parasite Relations

The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.


A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.


Infections, Togavirus
Togaviridae Disease
Infections, Togaviridae
Togaviridae Infections
Togavirus Infections

Virus diseases caused by the TOGAVIRIDAE.


Receptor, EphA6
EphA6 Protein
EphA6 Receptor

An eph family receptor that is found in a variety of neuronal regions of the BRAIN. In contrast to the other proteins in this class, it is expressed at higher levels in adult tissues than in embryonic tissues.


Cysteine-Rich Domain Associated with RING and TRAF Domains Protein 1

A widely expressed member of the TNF receptor-associated family that may play a role in neuronal development and EMBRYOGENESIS. Although TNF receptor-associated factor 4 does not strongly associate with TUMOR NECROSIS FACTOR RECEPTORS it may be a signaling partner with the GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN that plays a role in the activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES and NF-KAPPA B.


A family of DNA helicases that participate in DNA REPLICATION. They assemble into hexameric rings with a central channel and unwind DNA processively in the 5' to 3' direction. DnaB helicases are considered the primary replicative helicases for most prokaryotic organisms.


Caudal Type Homeo Box Transcription Factor 2

Caudal Type Homeobox Transcription Factor 2

An antennapedia-like homeodomain transcription factor that regulates the expression of multiple genes in the INTESTINAL MUCOSA. It plays a critical role in many processes from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.


National Eye Institute (U.S.)
National Eye Institute
NEI (US)

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research on the causes, diagnosis, and treatment of diseases of the eye and visual system. It was originally part of the National Institute of Neurological Diseases and Blindness. The National Eye Institute was established in 1968.


Duck Hepatitis B Viruses
DHBV
Duck hepatitis B virus
Hepatitis B Viruses, Duck
Hepatitis B Virus, Duck

A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.


Procedure, Elective Surgical
Elective Surgical Procedure
Elective Surgical Procedures
Procedures, Elective Surgical
Surgical Procedures, Elective
Surgical Procedure, Elective

Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.


An individual intelligence test designed primarily for school children to predict school performance and the ability to adjust to everyday demands.


Cultivation of natural faunal resources of water. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Glucose Solution, Hypertonic
Hypertonic Solution, Glucose
Hypertonic Solutions, Glucose
Glucose Solutions, Hypertonic
Hypertonic Glucose Solution

Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.


Health Services for People with Disabilities

Health Services for Persons with Disabilities

Health services and access for DISABLED PERSONS. Disabilities include impairments, activity limitations, or participation restrictions, and reflect the interaction between the individual with the disability and personal and environmental factors.


Medical Schools
Medical School
Schools, Medical
School, Medical

Educational institutions for individuals specializing in the field of medicine.


Knobbed structures formed from and attached to plant roots, especially of LEGUMES, which result from symbiotic infection by nitrogen fixing bacteria such as RHIZOBIUM or FRANKIA. Root nodules are structures related to MYCORRHIZAE formed by symbiotic associations with fungi.


Porfimer Sodium
Photofrin
DHP Ether
Porfimer
Photofrin II
Dihematoporphyrin Ester
Dihematoporphyrin Ether

The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.


Ischemic Preconditioning
Ischemic Pre-Conditioning

A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)