Hypomagnesemia-Hypokalemia, Primary Renotubular, with Hypocalciuria

Primary Renotubular, Hypokalemia-Hypomagnesemia with Hypocalciuria

Hypokalemia-Hypomagnesemia, Primary Renotubular, with Hypocalciuria

Primary Renotubular, Hypomagnesemia-Hypokalemia with Hypocalciuria

Tubular Hypomagnesemia-Hypokalemia with Hypocalcuria

An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.


PARP-Dependent Cell Death
PARP-1-Dependent Cell Death
Parthanatos

A type of regulated cell death initiated by hyperactivation of POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1) as a consequence of DNA DAMAGE; OXIDATIVE STRESS; HYPOXIA; HYPOGLYCEMIA; or INFLAMMATION. This leads to DNA FRAGMENTATION and CHROMATIN condensation.


ADPribose
Adenosine Diphosphoribose
ADP-Ribose
ADP Ribose
Adenosine 5'-Diphosphoribose
Adenosine Diphosphate Ribose

An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.


Injuries, Electric
Electrocution, Accidental
Electric Injuries

Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.


Immunoglobulin Genes
Genes, Immunoglobulin
Genes, Ig

Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).


Mixed Connective Tissue Disease
MCTD
Sharp Syndrome
Connective Tissue Disease, Mixed

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.


Carbonic Anhydrase V
Carbonic Anhydrase Isozyme V

A carbonic anhydrase isoenzyme found in MITOCHONDRIA where it provides bicarbonate ions that are components in the urea cycle and in GLUCONEOGENESIS.


Computer disks storing data with a maximum reduction of space and bandwidth. The compact size reduces cost of transmission and storage.


Musculoskeletal and Neural Physiological Phenomenon

Musculoskeletal and Neural Physiological Concepts

Musculoskeletal and Neural Physiological Phenomena

Properties, and processes of the MUSCULOSKELETAL SYSTEM and the NERVOUS SYSTEM or their parts.


Psychologic Tests
Tests, Psychological
Psychological Test
Test, Psychological
Psychological Tests

Standardized tests designed to measure abilities, as in intelligence, aptitude, and achievement tests, or to evaluate personality traits.


5S rRNA
5S Ribosomal RNA
RNA, Ribosomal, 5S

Constituent of the 50S subunit of prokaryotic ribosomes containing about 120 nucleotides and 34 proteins. It is also a constituent of the 60S subunit of eukaryotic ribosomes. 5S rRNA is involved in initiation of polypeptide synthesis.


Selacryn
ANP-3624
Tienilic Acid
Thienylic Acid
SKF-62698
Ticrynafen

A novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.


LAV-2
Human T Lymphotropic Virus Type IV
HIV-2
HIV-II
Immunodeficiency Virus Type 2, Human
Human T-Lymphotropic Virus Type IV
SBL-6669
Human immunodeficiency virus 2
Human Immunodeficiency Virus Type 2
HTLV-IV

An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIMIAN IMMUNODEFICIENCY VIRUS and infects only T4-lymphocytes expressing the CD4 phenotypic marker.


Cystathionine Synthetase
Serine Sulfhydrase
beta-Thionase
Cystathionine beta-Synthase

A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.


Poly-Ig Receptor
Receptor, Polymeric Ig
Polyimmunoglobulin Receptor
Polymeric Immunoglobulin Receptor
Receptor, Polyimmunoglobulin
Receptors, Polymeric Immunoglobulin
Polymeric Ig Receptor
Polymeric Immunoglobulin Receptors

Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)


Neuropeptide Y Receptors
Neuropeptide Y Receptor
Receptors, Neuropeptide Y

Cell surface proteins that bind neuropeptide Y with high affinity and trigger intracellular changes which influence the behavior of cells.


Retinoblastoma-Associated Protein 46
RbAp46 Protein
RBBP7 Protein
Retinoblastoma-Binding Protein 7

A retinoblastoma-binding protein that has an affinity for core HISTONES. It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2.


Protrusion of tissue at or near the site of an incision from a previous surgery.


The chromosomal constitution of cells, in which each type of CHROMOSOME is represented once. Symbol: N.


17-beta-Hydroxysteroid Dehydrogenase Type 5

Aldo-keto reductase that functions as a bi-directional  17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of  9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.


Protein Tyrosine Phosphatase, Non-Receptor Type 12

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.


Patterns, Dental Practice
Practice Patterns, Dentists'
Practice Pattern, Dental
Dental Practice Patterns
Practice Patterns, Dental
Pattern, Dental Practice
Dentist's Practice Patterns
Dental Practice Pattern

Patterns of practice in dentistry related to diagnosis and treatment.


A mitosporic Onygenaceae fungal genus which causes adiaspiromycosis, a pulmonary mycosis of man and rodents. One of its teleomorphs is Ajellomyces.


An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.


Mad2 Mitotic Arrest Deficient-like 1 Proteins

Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.


Health Services for Transgendered Persons

Access to specialized care for transgender populations. Health systems organized to take account of the special healthcare needs of marginalized groups who may face barriers in accessing health services. (http://www.who.int/reproductivehealth/topics/linkages/guidance_package.pdf)


CD208 Antigens
Lysosomal-Associated Membrane Protein 3
LAMP-3 Protein
DC-LAMP Protein
Antigens, CD208

A lysosomal-associated membrane glycoprotein that is expressed at high levels in mature DENDRITIC CELLS.


Bifidobacterium lactis
Bifidobacterium animalis
Bifidobacterium BB-12
Bifidobacterium animalis subsp animalis
Bifidobacterium animalis subsp lactis

A species of Bifidobacterium that occurs in the LARGE INTESTINE of humans and other mammals and in FERMENTED DAIRY PRODUCTS. It is used as a PROBIOTIC.


Brunemycin Rufocromomycin Nigrin NSC-45383 Bruneomycin Streptonigrin

Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.


Cell Differentiation
Differentiation, Cell

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.


Transferrin-Binding Protein Complex, Bacterial

A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum.


Surgical Procedures, Oral, Preprosthetic

Surgery necessary for a denture to rest on a firm base, free from marked osseous protuberances or undercuts, and devoid of interfering muscle attachments, excess mucoperiosteum, hyperplasias, and fibrous or papillary growths.


Pathogen-Host Interactions
Host-Pathogen Relations
Host-Pathogen Interactions

The interactions between a host and a pathogen, usually resulting in disease.


gamma-Crystallins
Crystallins, gamma
gamma-Crystallin

A subclass of crystallins that found in the lens (LENS, CRYSTALLINE) of VERTEBRATES. Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. They are composed of monomeric subunits.


Hemoglobins, Abnormal
Abnormal Hemoglobins

Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.


C2 Domain
C2 Tensin-type Domain
C2 Domains

Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the protein and co-ordinates the binding of 2 to 3 calcium ions; however, not all C2 domains bind calcium. Examples of C2 domain-containing proteins include PROTEIN KINASE C and PTEN PHOSPHOHYDROLASE.


CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)

FAT (Fatty Acid Translocase) - CD36 Antigen

Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.


Platelet Derived Growth Factor
Platelet-Derived Growth Factor

Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.


Vaccines, Virus-Like Particle
Virus-Like Particle Vaccines

Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.


Staff, Medical
Staffs, Medical
Medical Staff
Medical Staffs

Professional medical personnel who provide care to patients in an organized facility, institution or agency.


Indian Health Service
Service, United States Indian Health
Indian Health Service (U.S.)
United States Indian Health Service
Service, Indian Health

A division of the UNITED STATES PUBLIC HEALTH SERVICE that is responsible for the public health and the provision of medical services to NATIVE AMERICANS in the United States, primarily those residing on reservation lands.


Hemin
Ferriprotoporphyrin IX Chloride
Ferriprotoporphyrin IX
Ferrihaem
Protohemin IX
Chlorohemin
Hematin
Ferriprotoporphyrin
Panhematin
Alkaline Hematin D-575
Protohemin
Ferriheme Chloride


Nerve Tissue Protein S 100
S100 Proteins
Antigen S 100
S100 Protein Family
S-100 Protein

A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.


Antigens, Neoplasm
Tumor Antigens
Neoplasm Antigens

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.


Host-Finding Behavior
Host-Searching Behavior
Host Seeking Behavior
Host-Seeking Behavior

Searching behavior by parasitic or commensal organisms, to find animals or plants that are a source of nourishment and habitation.


FGF Receptors
Fibroblast Growth Factor Receptors
Receptors, FGF
Receptors, Fibroblast Growth Factor
Heparin-Binding Growth Factor Receptor
FGF Receptor
Fibroblast Growth Factor Receptor

Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.


Powdered exudate from Astragalus gummifer and related plants. It forms gelatinous mass in water. Tragacanth is used as suspending agent, excipient or emulsifier in foods, cosmetics and pharmaceuticals. It has also been used as a bulk-forming laxative.


Bisphosphoglycerate Mutase
Diphosphoglyceromutase
Diphosphoglycerate Mutase
Bisphosphoglycerate Synthase
Bisphosphoglyceromutase

An enzyme that catalyzes the transfer of phosphate from C-3 of 1,3-diphosphoglycerate to C-2 of 3-phosphoglycerate, forming 2,3-diphosphoglycerate. EC 5.4.2.4.


Flow Microfluorimetry
Fluorescence-Activated Cell Sorting
Flow Cytometry
Cytofluorometry, Flow
Cytometry, Flow
Microfluorometry, Flow

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.


Germinal Cell Aplasia
Del Castillo Syndrome
Sertoli Cell-Only Syndrome

A type of male infertility in which no germ cells are visible in any of the biopsied SEMINIFEROUS TUBULES (type I) or in which germ cells are present in a minority of tubules (type II). Clinical features include AZOOSPERMIA, normal VIRILIZATION, and normal chromosomal complement.


Effectiveness, Biological Relative
Biological Effectiveness, Relative
Effectiveness, Biologic Relative
Relative Biological Effectiveness
Relative Biologic Effectiveness

The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.


Empyema, Tuberculous
Empyema, Pleural, Tuberculous

Empyema due to MYCOBACTERIUM TUBERCULOSIS.


An experimental lymphocytic leukemia of mice.


Aromatic Amino Acids
Amino Acid, Aromatic
Amino Acids, Aromatic

Amino acids containing an aromatic side chain.


Enterohemorrhagic E coli
Escherichia coli, Enterohemorrhagic
EHEC
E coli, Enterohemorrhagic
Enterohemorrhagic E. coli
Enterohemorrhagic Escherichia coli

Strains of ESCHERICHIA COLI that are a subgroup of SHIGA-TOXIGENIC ESCHERICHIA COLI. They cause non-bloody and bloody DIARRHEA; HEMOLYTIC UREMIC SYNDROME; and hemorrhagic COLITIS. An important member of this subgroup is ESCHERICHIA COLI O157-H7.


The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.


Carbonyl Cyanide meta-Chlorophenyl Hydrazone

Carbonyl Cyanide m Chlorophenyl Hydrazone

Carbonyl Cyanide m-Chlorophenyl Hydrazone

A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.


Metals, Alkali
Alkali Metals
Group 1 Elements

Metals that constitute group 1(formerly group Ia) of the periodic table. They are the most strongly electropositive of the metals. Note that HYDROGEN is not considered an alkali metal even though it falls under the group 1 heading in the periodic table.


GDP Dissociation Stimulators
GDP Dissociation Factor
GDP Exchange Factors
Guanine Nucleotide Exchange Factor
Guanine Nucleotide Releasing Factors
Guanine-Nucleotide-Releasing Factor
GDP-GTP Exchange Protein
Guanine Nucleotide Exchange Factors
GDP-GTP Reversing Factors

Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.


An enzyme that catalyzes the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also releasing the free amino acid. The enzyme acts on derivatives of glutamate, 2-aminobutyrate, alanine and glycine. The enzyme has been proposed to have a role in a gamma-glutamyl cycle for amino acid transport into cells in the intestines. EC 2.3.2.4.


Cholecalciferols substituted with two hydroxy groups in any position.


Phenylpropanolamine Hydrochloride
Propagest
Triaminic DM
Dexatrim
Norephedrine
Prolamine
Phenylpropanolamine

A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.


Sclerosis, Disseminated
Multiple Sclerosis, Acute Fulminating
MS (Multiple Sclerosis)
Multiple Sclerosis

An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)


Evidence-Based Medicine
Medicine, Evidence-Based

An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)


Circadian Rhythm Signaling Peptides and Proteins

A broad category of proteins that regulate the CIRCADIAN RHYTHM of an organism. Included here are proteins that transmit intracellular and intercellular signals in a chronological manner along with proteins that sense light and time-dependent changes in the environment such as the PHOTOPERIOD.


Axin Signaling Complex
beta-Catenin Destruction Complex
Axin Signaling Complex Proteins

A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.


A cone-shaped structure in plants made up of a mass of meristematic cells that covers and protects the tip of a growing root. It is the putative site of gravity sensing in plant roots.


Integrin alphaL
CD11a Antigens
CD11a Antigen
Antigens, CD11a

An alpha-integrin subunit found on lymphocytes, granulocytes, macrophages and monocytes. It combines with the integrin beta2 subunit (CD18 ANTIGEN) to form LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1.


SCYA20 Chemokine
MIP-3-alpha
Chemokine CCL20
Small Inducible Cytokine A20
Exodus-1 Chemokine
Macrophage Inflammatory Protein 3 alpha
CCL20 Chemokine

A CC-type chemokine with specificity for CCR6 RECEPTORS. It has activity towards DENDRITIC CELLS; T-LYMPHOCYTES; and B-LYMPHOCYTES.


Shipping Fever
Pasteurellosis, Pneumonic

Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.


Pharmaceutic Education, Continuing
Education, Pharmaceutic, Continuing
Education, Pharmaceutical, Continuing
Education, Pharmacy, Continuing
Continuing Pharmacy Education
Pharmaceutical Education, Continuing
Education, Continuing Pharmacy
Pharmacy Education, Continuing

Educational programs designed to inform graduate pharmacists of recent advances in their particular field.


Killer Cell Immunoglobulin-Like Receptor 2DL4

A KIR receptor that has specificity for HLA-G antigen. It contains D0 and D2 extracellular immunoglobulin-like domains and a long cytoplasmic tail.


Clathrin Uncoating Protein
70 kDa Heat-Shock Cognate Protein
Heat-Shock Cognate 70 Protein
Hsc70 Protein
HSC70 Heat-Shock Proteins
HSC73 Protein

A constitutively expressed subfamily of the HSP70 heat-shock proteins. They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION.


Implantable Neurostimulators
Implanted Nerve Stimulation Electrodes
Implanted Neurostimulators

Surgically placed electric conductors through which ELECTRIC STIMULATION of nerve tissue is delivered.


A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER.


Blood Coagulation Factor XIII, Activated

Despite the non-specific name it generally refers to Factor XIIIa. A few citations use the term nonspecifically with respect to the state of activation.


A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.


Employee Grievances
Grievances, Employee

Formal procedures whereby the employee expresses any dissatisfaction or feeling of injustice regarding the work situation.


Halorhodopsins
9-cis-Halorhodopsin
Halorhodopsin Chromoprotein
Halorhodopsin

Light driven chloride ion pumps that are ubiquitously found in halophilic archaea (HALOBACTERIALES).


Ascomycetous fungi, family Microascaceae, order Microascales, commonly found in the soil. They are causative agents of mycetoma, maduromycosis, and other infections in humans.


A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)


The narrow subcapsular outer zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to ALDOSTERONE. The final steps involve three successive oxidations by CYTOCHROME P-450 CYP11B2.


Delivery Room
Delivery Rooms
Centers, Hospital Birth
Centers, Hospital Birthing
Hospital Birth Centers
Rooms, Delivery
Center, Hospital Birth
Room, Delivery
Center, Hospital Birthing
Birthing Centers, Hospital
Hospital Birthing Centers
Birth Centers, Hospital


Immune System Disorders
Diseases of Immune System
Immunological Diseases
Immune System Diseases
Immune Disorders
Immunologic Diseases
Immune Diseases

Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.


Space Flight
Space Exploration
Space Travel
Spaceflight


The narrow tube connecting the YOLK SAC with the midgut of the EMBRYO; persistence of all or part of it in post-fetal life produces abnormalities, of which the commonest is MECKEL DIVERTICULUM.


High-Intensity Intermittent Exercise
High-Intensity Interval Training
Sprint Interval Training

A cardiovascular exercise strategy with alternating short periods of intense anaerobic exercise with less-intense recovery periods.


Blessed Thistle
Thistle, Blessed
Cnicus
Cardo-santo

A plant genus of the family ASTERACEAE. Members contain cnicin.


D-3-Hydroxyacyl-CoA Hydro-Lyase
2-Enoyl-CoA Hydratase 2
Enoyl-CoA Hydratase 2

A PEROXISOME-specific enzyme that catalyzes the hydration step of the beta-oxidation pathway.


The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.


Rats, Cotton
Hesperomyines
Neotoma
Hesperomyinae
Sigmodontinae
Sigmodon
Oryzomys
Rats, Rice

A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.


tRNA(Trp)
Transfer RNA, Trp
TRNATrp
Tryptophan-Specific tRNA
RNA, Transfer, Trp

A transfer RNA which is specific for carrying tryptophan to sites on the ribosomes in preparation for protein synthesis.


Glycogen Synthase Kinases
Glycogen Synthase Kinase

A class of protein-serine-threonine kinases that was originally found as one of the three types of kinases that phosphorylate GLYCOGEN SYNTHASE. Glycogen synthase kinases along with CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASES and CYCLIC AMP-DEPENDENT PROTEIN KINASES regulate glycogen synthase activity.


An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.


Parathyroid Disorders
Parathyroid Diseases

Pathological processes of the PARATHYROID GLANDS. They usually manifest as hypersecretion or hyposecretion of PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.


Ubiquitin-Activating Enzyme E1
Ubiquitin-Activating Enzymes
Ubiquitin-Activating Enzyme
Ubiquitination Activating Enzyme E1

A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated ubiquitin to one of the UBIQUITIN-PROTEIN LIGASES.


The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.


Cogan Syndrome
Cogans Syndrome
Cogan's Syndrome

A condition consisting of inflammatory eye disease usually presenting as interstitial KERATITIS, vestibuloauditory dysfunction, and large- to medium-vessel vasculitis.


Amlodipine Besylate, Olmesartan Medoxomil Drug Combination

Amlodipine Besylate-Olmesartan Medoxomil Drug Combination

A pharmaceutical preparation of amlodipine besylate and olmesartan medoxomil  that combines ANGIOTENSIN II TYPE I RECEPTOR ANTAGONIST and CALCIUM CHANNEL BLOCKER activities. It is used in the management of HYPERTENSION.


A conserved, approximately 50 amino acid, protein sequence that adopts a characteristic strongly bent, five stranded anti-parallel beta-sheet barrel-like fold. The Tudor domain recognizes dimethylated ARGININE through its negatively-charged surface and occurs in many proteins that co-localize with RNA; RIBONUCLEOPROTEINS or SINGLE-STRANDED DNA complexes in the CELL NUCLEUS; MITOCHONDRIA; or KINETOCHORES.


O-Diazoacetyl-L-serine LL-D05139a Azaserine Azeserine

Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.


Markov Chain
Markov Process
Markov Chains

A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.


Electronic Cigarette Vapor
E-Cigarette Vapor

Complex mixture of vaporized chemicals emitted during SMOKING of E-CIGARETTES.


Xeroderma Pigmentosum
Kaposi's Disease
Kaposi Disease

A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.


Ethoxyformic Anhydride
Diethyl Dicarbonate
Diethyl Oxydiformate
Diethyl Pyrocarbonate
Pyrocarbonic Acid Diethyl Ester
Diethylpyrocarbonate

Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.


Enzymes that catalyze the reversible reduction of NAD by NADPH to yield NADP and NADH. This reaction permits the utilization of the reducing properties of NADPH by the respiratory chain and in the reverse direction it allows the reduction of NADP for biosynthetic purposes.


A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2 isolated from Congolese bonobos (PAN PANISCUS).


Carbamoylaspartic Dehydrase
Dihydro-Orotase
Dihydroorotase
Dihydro-Orotate Amidohydrolase

An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.


Thiamine Phosphoester
Thiamine Monophosphate

Thiamine dihydrogen phosphate ester. The monophosphate ester of thiamine. Synonyms: monophosphothiamine; vitamin B1 monophosphate.


In Vivo Microscopy
Intravital Imaging
Intravital Microscopy

Type of microscopy used to study biological systems at high resolution.


Arrestin-2
beta-Arrestin 1A
ARRB1 Protein
Arrestin, beta 1
beta-Arrestin 1
beta-Arrestin 1B

A beta-arrestin that functions in the down-regulation of signaling by G-PROTEIN-COUPLED RECEPTORS. It is also a major regulator of INSULIN signaling via the ERK 1-2 PATHWAY, and many other signaling processes, especially in NEURONS and LEUKOCYTES.


A family of multidomain microfilament proteins that bind ACTIN FILAMENTS and INTEGRINS at FOCAL ADHESIONS. They generally consist of an N-terminal domain with homology to PHOSPHOTYROSINE PHOSPHATASE, a C2 DOMAIN; unique central regions rich in PROLINE; ALANINE; GLYCINE; and SERINE; an SH2 DOMAIN; and a C-terminal phosphotyrosine-binding region. They are involved in CELL MIGRATION; CELL ADHESION; SIGNAL TRANSDUCTION; and reorganization of the CYTOSKELETON.


Drug Partial Agonism
Drug Agonism, Partial

Drug agonism involving selective binding but reduced effect. This can result in some degree of DRUG ANTAGONISM.


A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.


The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.


Clathrin Assembly Protein Complex beta Subunits

A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.


Megacephaly Megalencephaly Macrocephaly Megalocephaly

A congenital abnormality in which the occipitofrontal circumference is greater than two standard deviations above the mean for a given age. It is associated with HYDROCEPHALUS; SUBDURAL EFFUSION; ARACHNOID CYSTS; or is part of a genetic condition (e.g., ALEXANDER DISEASE; SOTOS SYNDROME).


B30.2-SPRY Domain
PRYSPRY Domain
PRY Domain
PRY-SPRY Domain
B30.2 Domain
SPRY Domain

A protein interaction domain that is characterized by a bent "beta-sandwich" consisting of two antiparallel beta-sheets. It occurs in eukaryotic proteins, including many TRIPARTITE MOTIF PROTEINS, which function in a variety of cellular processes.


Warfare Agents, Chemical
Agents, Chemical Warfare
Chemical Warfare Agents

Chemicals that are used to cause the disturbance, disease, or death of humans during WARFARE.


Cytochrome C Oxidase Deficiency
Complex IV Deficiency
Deficiency, Cytochrome-c Oxidase
Cytochrome-c Oxidase Deficiency
Cox Deficiency
Mitochondrial Complex IV Deficiency
Cytochrome Oxidase Deficiency

A disease that results from a congenital defect in ELECTRON TRANSPORT COMPLEX IV. Defects in ELECTRON TRANSPORT COMPLEX IV can be caused by mutations in the SURF1, SCO2, COX10, or SCO1 genes. ELECTRON TRANSPORT COMPLEX IV deficiency caused by mutation in SURF1 manifests itself as LEIGH DISEASE; that caused by mutation in SCO2 as fatal infantile cardioencephalomyopathy; that caused by mutation in COX10 as tubulopathy and leukodystrophy; and that caused by mutation in SCO1 as early-onset hepatic failure and neurologic disorder. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#220110, May 17, 2001)


Sodium Channel Agonists
Sodium Channel Stimulators
Sodium Channel Activators

A class of drugs that stimulate sodium influx through cell membrane channels.


Neurological Rehabilitation
Neurorehabilitation
Neurologic Rehabilitation

Physician-supervised programs designed to rehabilitate people with diseases, trauma, or disorders of the NERVOUS SYSTEM.


Drug Release
Drug Liberation
Drug Dissolution

Release of drugs from DOSAGE FORMS into solution.


RNA, Ribosomal, 28S
28S rRNA
28S Ribosomal RNA

Constituent of the 60S subunit of eukaryotic ribosomes. 28S rRNA is involved in the initiation of polypeptide synthesis in eukaryotes.


DSS-AHC Critical Region on the X Chromosome, Gene 1 Protein

Nuclear Receptor Subfamily 0, Group B, Member 1

An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. It is unlike most orphan nuclear receptors in that it appears to lack an essential DNA-binding domain and instead acts as a transcriptional co-repressor. Mutations in the gene Dax-1 cause congenital adrenal hypoplasia.


Avian Myeloblastosis Virus
Myeloblastosis Virus, Avian

A species of ALPHARETROVIRUS causing anemia in fowl.


Donor Selection
Tissue and Organ Selection
Donor Screening
Donor Exclusion

The procedure established to evaluate the donated TISSUES or organs prior to selection for reuse. Donated specimens may be disqualified for reuse due to deteriorating conditions and risk factors, such as INFECTIONS, and HEREDITARY DISEASES.


Fetal Pyelectasis
Prenatal Fetal Pyelectasis
Pyelectasis

Dilation of fetal KIDNEY PELVIS. It is a common PRENATAL ULTRASONOGRAPHY finding with no significant long-term sequelae.


Satellite RNAs
Satellite RNA
RNA, Satellite

Small, linear single-stranded RNA molecules functionally acting as molecular parasites of certain RNA plant viruses. Satellite RNAs exhibit four characteristic traits: (1) they require helper viruses to replicate; (2) they are unnecessary for the replication of helper viruses; (3) they are encapsidated in the coat protein of the helper virus; (4) they have no extensive sequence homology to the helper virus. Thus they differ from SATELLITE VIRUSES which encode their own coat protein, and from the genomic RNA; (=RNA, VIRAL); of satellite viruses. (From Maramorosch, Viroids and Satellites, 1991, p143)


Costs, Hospital
Hospital Costs
Cost, Hospital

The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).


Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.


CD191 Antigens
CD191 Antigen
CCR1 Receptor
Receptors, CCR1
CC Chemokine Receptor 1
CCR1 Receptors
Antigens, CD191
CC Chemokine Receptors 1

CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.


Cyamposis
Guar
Cyamopsis tetragonoloba
Cyamopsis

A plant genus of the family FABACEAE that is the source of guar gum.


Physcomitrella
Bryopsida
Mosses, True
Ceratodon

A class of plants within the Bryophyta comprising the mosses, which are found in both damp (including freshwater) and drier situations. Mosses possess erect or prostrate leafless stems, which give rise to leafless stalks bearing capsules. Spores formed in the capsules are released and grow to produce new plants. (Concise Dictionary of Biology, 1990). Many small plants bearing the name moss are in fact not mosses. The "moss" found on the north side of trees is actually a green alga (CHLOROPHYTA). Irish moss is really a red alga (RHODOPHYTA). Beard lichen (beard moss), Iceland moss, oak moss, and reindeer moss are actually LICHENS. Spanish moss is a common name for both LICHENS and an air plant (TILLANDSIA usneoides) of the pineapple family. Club moss is an evergreen herb of the family LYCOPODIACEAE.


Bang's Disease
Brucellosis, Bovine
Bang Disease

A disease of cattle caused by bacteria of the genus BRUCELLA leading to abortion in late pregnancy. BRUCELLA ABORTUS is the primary infective agent.


Oncogene Protein akt
akt-Oncogene Protein
v-akt Protein
v-akt Kinase Transforming Protein
Oncogene Protein v-akt

A viral oncoprotein originally isolated from a murine T CELL LYMPHOMA infected with the acutely transforming retrovirus AKT8. v-akt protein is the viral homologue of PROTO-ONCOGENE PROTEINS C-AKT.


Heart Enlargement, Physiological
Cardiomegaly, Exercise-Induced
Athlete's Heart Syndrome

Heart enlargement and other remodeling in cardiac morphology and electrical circutry found in individuals who participate in intense repeated exercises.


Veterinary Drug
Veterinary Pharmaceuticals
Drugs, Veterinary
Pharmaceuticals, Veterinary
Veterinary Drugs
Drug, Veterinary

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.


The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.


Neuroendocrine cells in the glands of the GASTRIC MUCOSA. They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to GASTRIN by releasing histamine which acts as a paracrine stimulator of the release of HYDROCHLORIC ACID from the GASTRIC PARIETAL CELLS.


Killer Cell Immunoglobulin-Like Receptors

Killer Immunoglobulin-Like Receptor (KIR) Family of Receptors

A family of receptors found on NK CELLS that have specificity for a variety of HLA ANTIGENS. KIR receptors contain up to three different extracellular immunoglobulin-like domains referred to as D0, D1, and D2 and play an important role in blocking NK cell activation against cells expressing the appropriate HLA antigens thus preventing cell lysis. Although they are often referred to as being inhibitory receptors, a subset of KIR receptors may also play an activating role in NK cells.


Hysterical Personality
Personality, Hysterical
Histrionic Personality Disorder
Personality Disorder, Histrionic

A personality disorder characterized by overly reactive and intensely expressed or overly dramatic behavior, proneness to exaggeration, emotional excitability, and disturbances in interpersonal relationships.


EHV-1
Herpesvirus 1, Equid
Equine abortion Virus
Herpesvirus 1 (alpha), Equine
Equine Herpesvirus 1
Equid Herpesvirus 1

A species of VARICELLOVIRUS causing abortion and respiratory disease in horses.


A fibrinolytic and thrombolytic enzyme from Aspergillus oryzae. EC 3.4.99.-.


Double Outlet Right Ventricle, Noncommitted VSD

Double Outlet Right Ventricle, Subaortic VSD

Double Outlet Right Ventricle, Subpulmonary VSD

A subtype with ventricular septal defect clearly away from the semilunar valves of the AORTA and the PULMONARY ARTERY.


Subdural Hematoma, Chronic
Hemorrhage, Subdural, Chronic
Hematoma, Subdural, Chronic

Accumulation of blood in the SUBDURAL SPACE with delayed onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.


Dressings, Spray-On
Occlusive Dressings
Bandages, Occlusive
Dressings, Occlusive

Material, usually gauze or absorbent cotton, used to cover and protect wounds, to seal them from contact with air or bacteria. (From Dorland, 27th ed)


2,3-Dithiopropan-1-o1
Cadmium 2,3-Dimercaptopropanol
B.A.L.
BAL in Oil
2,3-Dimercaptopropanol
Dicaptol
British Anti-Lewisite Agent
Dimercaprol
British Anti-Lewisite

An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.


Psychology, Perceptual
Social Psychology
Psychology, Social

Branch of psychology concerned with perception of the beliefs, attitudes and opinions of others.


Click Chemical Reactions
Click Chemical Techniques
Click Chemistry

Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.


ATP-(2'-5')oligo(A)adenylyltransferase
2',5'-Oligoadenylate Polymerase
2',5'-Oligo(A) Synthetase
2-5A Synthetase
2',5'-Oligoadenylate Synthetase
(2'-5')An Polymerase
2',5'-Oligo(A) Polymerase
2,5 Oligoadenylate Synthetase
2,5 Oligoadenylate Polymerase

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.


Adrenergic alpha-1 Receptor Blockers
Adrenergic alpha-1 Antagonists
Adrenergic alpha1-Antagonists
alpha-1 Adrenergic Blocking Agents
alpha1-Adrenergic Antagonists
alpha1-Adrenoceptor Blocker
Adrenergic alpha-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.


Antineoplastic Agents
Antitumor Agents
Anticancer Agents
Antitumor Drugs
Antineoplastic Drugs
Chemotherapeutic Anticancer Drug
Cancer Chemotherapy Agents
Antineoplastics
Chemotherapeutic Anticancer Agents
Cancer Chemotherapy Drugs

Substances that inhibit or prevent the proliferation of NEOPLASMS.


Receptors, Cyclic AMP
Cyclic AMP Receptors
cAMP Receptor
Receptors, cAMP
Cyclic AMP Receptor
cAMP Receptors

Cell surface proteins that bind cyclic AMP with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized cyclic AMP receptors are those of the slime mold Dictyostelium discoideum. The transcription regulator CYCLIC AMP RECEPTOR PROTEIN of prokaryotes is not included nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.


Sodium Morrhuate
Scleromate
Morrhuate Sodium
Varicoccid

The sodium salts of the fatty acids in cod liver oil; an irritant and sclerosing agent used to treat varicose veins and arthritic joints.


Green Algae
Algae, Green
Chlorophyta
Chlorophytina

A subdivision of green algae in the division CHLOROPHYTA, subkingdom VIRIDIPLANTAE.


Patient Non-Attendance
Patient No-Show
No-Show Patients

PATIENTS who do not turn up for scheduled healthcare appointments. Do not confuse with PATIENT DROPOUTS.


Unconventional Myosin VIIa
MYO7A protein
Myosin VIIa
Myosin-VIIa

Also referred to as unconventional myosin VIIa, these are actin-based motor molecules with ATPase activity that function in intracellular movements (e.g., HAIR CELLS, AUDITORY).


Low-Molecular-Weight Kininogen
Kininogen, Low-Molecular-Weight
Low Molecular Weight Kininogen
Low-Molecular-Weight Kininogens
Low Molecular Weight Kininogens
LMWK

A protein, molecular weight 50 kD, located in various normal tissues. Upon cleavage by KALLIKREINS, it forms KALLIDIN. Kallidin, in turn, is converted into BRADYKININ. (From Stedman, 25th ed)


The wide middle zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to cortisol (HYDROCORTISONE) via 17-ALPHA-HYDROXYPROGESTERONE.


Mating Preference, Animal
Sexual Selection, Animal

The selection or choice of sexual partner in animals. Often this reproductive preference is based on traits in the potential mate, such as coloration, size, or behavioral boldness. If the chosen ones are genetically different from the rejected ones, then NATURAL SELECTION is occurring.


A class of animal lectins that bind specifically to beta-galactoside in a calcium-independent manner. Members of this class are distiguished from other lectins by the presence of a conserved carbohydrate recognition domain. The majority of proteins in this class bind to sugar molecules in a sulfhydryl-dependent manner and are often referred to as S-type lectins, however this property is not required for membership in this class.


Hemostasis, Endoscopic
Endoscopic Hemostasis

Control of bleeding performed through the channel of the endoscope. Techniques include use of lasers, heater probes, bipolar electrocoagulation, and local injection. Endoscopic hemostasis is commonly used to treat bleeding esophageal and gastrointestinal varices and ulcers.


Receptor-CD3 Complex, Antigen, T-Cell
T-Cell Antigen Receptor-CD3 Complex
TCR-CD3 Complex

Molecule composed of the non-covalent association of the T-cell antigen receptor (RECEPTORS, ANTIGEN, T-CELL) with the CD3 complex (CD3 COMPLEX). This association is required for the surface expression and function of both components. The molecule consists of up to seven chains: either the alpha/beta or gamma/delta chains of the T-cell receptor, and four or five chains in the CD3 complex.


United States Patient Self-Determination Act

The purpose of this 1990 federal act is to assure that individuals receiving health care services will be given an opportunity to participate in and direct health care decisions affecting themselves. Under this act, hospitals, health care agencies, and health maintenance organizations are responsible for developing patient information for distribution. The information must include patients' rights, advance directives, living wills, ethics committees' consultation and education functions, limited medical treatment (support/comfort care only), mental health treatment, resuscitation, restraints, surrogate decision making and transfer of care. (from JCAHO, Lexicon, 1994)


Nucleus Solitarius
Solitary Tract Nucleus
Nucleus of the Solitary Tract
Nuclei Tractus Solitarii
Nucleus of Tractus Solitarius
Nucleus Tractus Solitarii
Solitary Nuclear Complex
Solitary Nucleus
Nucleus of Solitary Tract

GRAY MATTER located in the dorsomedial part of the MEDULLA OBLONGATA associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of AUTONOMIC NERVOUS SYSTEM regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of HOMEOSTASIS. The solitary nucleus is also notable for the large number of NEUROTRANSMITTERS which are found therein.


Asp-tRNA Ligase
Aspartyl T RNA Synthetase
Aspartate-tRNA Ligase
Aspartyl-tRNA Synthetase

An enzyme that activates aspartic acid with its specific transfer RNA. EC 6.1.1.12.


Transcription Factor Elk1
Elk1 ets-Domain Protein
Elk-1 ets-Domain Protein
Elk-1 Transcription Factor
Elk1 Transcription Factor
Ets-Like Protein 1
ets-Domain Protein Elk-1

A member of the ternary complex family of ets-related transcription factors that is regulated by MITOGEN-ACTIVATED PROTEIN KINASES including JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; and P38 MITOGEN-ACTIVATED PROTEIN KINASES.


Medical Bibliographies
Medical Bibliography
Bibliographies, Medical
Bibliography, Medical
Bibliography of Medicine
Medicine, Bibliographies
Medicine, Bibliography

A list of works, documents, and other publications on medical subjects and topics of interest to the field of medicine.


Silica Hydrate
Hydrated Silica Gel
Silicate Hydrate
Silicic Acid

A hydrated form of silicon dioxide. It is commonly used in the manufacture of TOOTHPASTES and as a stationary phase for CHROMATOGRAPHY.


RNA, Complementary
cRNA Probes
cRNA
Complementary RNA

Synthetic transcripts of a specific DNA molecule or fragment, made by an in vitro transcription system. This cRNA can be labeled with radioactive uracil and then used as a probe. (King & Stansfield, A Dictionary of Genetics, 4th ed)


A small whitish spot on the surface of the EGG YOLK where cleavage begins. Upon fertilization the cytoplasm streams from the vegetal pole away from the yolk to the animal pole where cleavage will occur. This germinal area eventually flattens into a layer of cells (BLASTODERM) that covers the yolk completely.


A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism.


Services, Rural Health
Health Services, Rural
Rural Health Services
Rural Health Center

Health services, public or private, in rural areas. The services include the promotion of health and the delivery of health care.


A species of the genus PARVOVIRUS and a host range variant of FELINE PANLEUKOPENIA VIRUS. It causes a highly infectious fulminating ENTERITIS in dogs producing high mortality. It is distinct from CANINE MINUTE VIRUS, a species in the genus BOCAVIRUS. This virus can also infect cats and mink.


Pharmaceuticals
Preparations, Pharmaceutical
Drugs
Pharmaceutical Preparations
Pharmaceutic Preparations
Pharmaceutical Products

Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.


An enduring, learned predisposition to behave in a consistent way toward a given class of objects, or a persistent mental and/or neural state of readiness to react to a certain class of objects, not as they are but as they are conceived to be.


Antitrichomonals
Antitrichomonal Drugs
Antitrichomonal Agents
Trichomonicides

Agents used to treat trichomonas infections.


Viral Sexually Transmitted Diseases
Venereal Diseases, Viral
Viral Venereal Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Disease, Viral
Viral Sexually Transmitted Disease

Viral diseases which are transmitted or propagated by sexual conduct.


Connecting Peptide
C-Peptide
C-Peptide, Proinsulin
Proinsulin C-Peptide

The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.


The granting of a license to practice pharmacy.


Heme Synthetase
Ferrochelatase
Protoheme Ferro-Lyase
Porphyrin-Metal Chelatase
Zinc Chelatase

A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.


Nevus
Skin Mole
Moles, Skin
Skin Moles
Nevi
Mole, Skin

A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.


The principles of proper professional conduct concerning the rights and duties of the dentist, relations with patients and fellow practitioners, as well as actions of the dentist in patient care and interpersonal relations with patient families. (From Stedman, 25th ed)


Ribonucleic acid in plants having regulatory and catalytic roles as well as involvement in protein synthesis.


Deoxyriboendonuclease IV
Deoxyribonuclease IV (Phage T4-Induced)
Endonuclease IV
Redoxyendonuclease

An enzyme which catalyzes the endonucleolytic cleavage of phosphodiester bonds at purinic or apyrimidinic sites (AP-sites) to produce 5'-Phosphooligonucleotide end products. The enzyme prefers single-stranded DNA (ssDNA) and was formerly classified as EC 3.1.4.30.


Economic aspects related to the management and operation of a hospital.


Small Leucine-Rich Proteoglycans
Small Leucine-Rich Repeat Proteoglycan
SLRP Proteoglycans
Small Leucine-Rich Repeat Proteoglycans

A proteoglycan family (SLRPs) that is defined by a central domain which consists of a variable number of repeats of the motif LXXLxLXXNxL, where L may be LEUCINE; ISOLEUCINE; VALINE; or other hydrophobic amino acids. The N-terminal contains four conserved CYSTEINE residues and may be modified depending on function. SLRPs provide structural support to the EXTRACELLULAR MATRIX and are critical for regulating its assembly and dynamics at CELL-MATRIX JUNCTIONS.


Mi-2 Nucleosome Remodeling and Deacetylase Complex

A enzyme complex involved in the remodeling of NUCLEOSOMES. The complex is comprised of at least seven subunits and includes both histone deacetylase and ATPase activities.


Inflammation of the pars plana, ciliary body, and adjacent structures.


Homeotic Proteins
Homeo Domain Proteins
Homeodomain Proteins
Homeobox Proteins
Homeoproteins

Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).


Zinc Dimethyldithiocarbamate
Fuklasin
Cuman L
Zerlate
Ziram
Milbam

An industrial fungicide with low mammalian toxicity, although it does possess an irritant capacity for skin and mucous membranes.


A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.


Yeast-like ascomycetous fungi of the family Saccharomycetaceae, order SACCHAROMYCETALES isolated from exuded tree sap.


Chromosomes, Human, 6-12
Group C Chromosomes
Chromosomes, Human, 6-12 and X
Chromosomes C

The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.


Opisthorchis sinensis Infection
Clonorchis Infection
Clonorchis sinensis Infection
Clonorchiasis

Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)


Polytene Chromosome
Polytene Chromosomes

Extra large CHROMOSOMES, each consisting of many identical copies of a chromosome lying next to each other in parallel.


Medicare Hospital Insurance Program
Hospital Insurance Program, Medicare
Medicare Part A

The compulsory portion of Medicare that is known as the Hospital Insurance Program. All persons 65 years and older who are entitled to benefits under the Old Age, Survivors, Disability and Health Insurance Program or railroad retirement, persons under the age of 65 who have been eligible for disability for more than two years, and insured workers (and their dependents) requiring renal dialysis or kidney transplantation are automatically enrolled in Medicare Part A.


Level of engagement in educationally purposeful activities, satisfaction, acquisition of desired knowledge, skills, and competencies, persistence and attainment of educational outcomes.


Liver Abscess, Pyogenic
Pyogenic Hepatic Abscess
Pyogenic Liver Abscess

Single or multiple areas of PUS due to bacterial infection within the hepatic parenchyma. It can be caused by a variety of BACTERIA, local or disseminated from infections elsewhere such as in APPENDICITIS; CHOLECYSTITIS; PERITONITIS; and after LIVER TRANSPLANTATION.


p38delta
SAPK4
Mitogen-Activated Protein Kinase 13
Stress-Activated Protein Kinase 4
MAPK13 Mitogen-Activated Protein Kinase
p38delta MAP Kinase

A 38-kDa mitogen-activated protein kinase found expressed at high levels in LUNG; KIDNEY; TESTIS; PANCREAS; and SMALL INTESTINE. It may play a role in regulating functions such as CELL DIFFERENTIATION and APOPTOSIS of EPITHELIAL CELLS.


A benign osteoblastic tumor with central vascularized nidus surrounded by normal reactive bone. It occurs especially in second decade of life most commonly in the femoral neck but can occur in any bone and any site within a bone.


Wegener's Granulomatosis
Granulomatosis with Polyangiitis
Granulomatosis, Wegener's
Wegener Granulomatosis

A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.


Haemophilus parainfluenzae
Hemophilius parainfluenzae

A species of gram-negative bacteria in the genus HAEMOPHILUS, ubiquitous in the human ORAL CAVITY and PHARYNX. It has low pathogenicity but is occasionally implicated in ENDOCARDITIS in humans.


Muerto Canyon Virus
Sin Nombre virus
Four Corners Virus

A species of HANTAVIRUS which emerged in the Four Corners area of the United States in 1993. It causes a serious, often fatal pulmonary illness (HANTAVIRUS PULMONARY SYNDROME) in humans. Transmission is by inhaling aerosolized rodent secretions that contain virus particles, carried especially by deer mice (PEROMYSCUS maniculatus) and pinyon mice (P. truei).


Malignant Catarrhal Fever
Malignant Catarrh

A herpesvirus infection of cattle characterized by catarrhal inflammation of the upper respiratory and alimentary epithelia, keratoconjunctivitis, encephalitis and lymph node enlargement. Syn: bovine epitheliosis, snotsiekte.


A plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.


A specific pair of GROUP C CHROMSOMES of the human chromosome classification.


Passive Motion Therapy, Continuous
Motion Therapy, Continuous Passive
Movement Therapy, Continuous Passive
Continuous Passive Motion Therapy
CPM Therapy
Continuous Passive Movement Therapy
Passive Movement Therapy, Continuous

Movement of a body part initiated and maintained by a mechanical or electrical device to restore normal range of motion to joints, muscles, or tendons after surgery, prosthesis implantation, contracture flexion, or long immobilization.


Receptors, Interleukin-16
Il-16 Receptors
Interleukin-16 Receptors

Cell surface receptors for INTERLEUKIN-16. Although initial studies have identified CD4 ANTIGENS as receptors for interleukin-16, the fact that cells from KNOCKOUT MICE which lack CD4 antigen are responsive to IL-16 indicate that are at least 2 distinct receptors subtypes.


An abnormal extension of a gingival sulcus not accompanied by the apical migration of the epithelial attachment.


Oradexon Decaspray Methylfluorprednisolone Decaject Hexadecadrol Dexpak Maxidex Hexadrol Dexasone Dexamethasone Decaject-L.A. Millicorten Decameth


Acids, Noncarboxylic
Noncarboxylic Acids

Inorganic acids with a non metal, other than carbon, attached to hydrogen, or an acid radical containing no carbon.


PSD95 Protein
Discs Large Homolog 4 Protein
SAP90 Protein
SAP-90 Protein
Postsynaptic Density Protein 95
Synapse-Associated Protein 90
Disks Large Homolog 4 Protein
PSD-95 Protein

A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.


Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

Congenital Hypoplastic Anemia of Blackfan and Diamond

A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)


Poly-Adenosine Diphosphate-Ribose
Poly-ADPR
Poly ADP Ribose
Poly Adenosine Diphosphate Ribose
Poly(ADP-Ribose)

A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.


Fetal Mummification
Fetal Death
Fetal Demise

Drying and shriveling of the fetus that sometimes occurs after the resorption of fluid following fetal death in veterinary animals.


X-Ray Therapy
Therapy, Xray
Roentgenotherapy
Therapy, X Ray
Xray Therapy

Medical treatment involving the use of controlled amounts of X-Rays.


Brain-Computer Interface
Brain-Computer Interfaces
Brain-Machine Interfaces

Instrumentation consisting of hardware and software that communicates with the BRAIN. The hardware component of the interface records brain signals, while the software component analyzes the signals and converts them into a command that controls a device or sends a feedback signal to the brain.


A class in the phylum MOLLUSCA comprised of SQUID; CUTTLEFISH; OCTOPUS; and NAUTILUS. These marine animals are the most highly organized of all the mollusks.


Korean War, 1950-1953
Korean Conflict
Korean War

An armed conflict between Communist and non-Communist forces in Korea from June 25, 1950, to July 27, 1953. The parties included United Nations forces from 15 member nations under United States command against military from North Korea and the Peoples Republic of China.


A genus of gram-negative, aerobic, rod-shaped bacteria, in the family BURKHOLDERIACEAE, that are mobile by means of peritrichous FLAGELLA. The genus was formerly called Wautersia and species in this genus were formerly in the genus RALSTONIA.


Polychemotherapy
Therapy, Combination Drug
Combination Drug Therapy
Drug Therapy, Combination
Combination Chemotherapy
Drug Polytherapy
Chemotherapy, Combination

Therapy with two or more separate preparations given for a combined effect.


Streptococcus pneumoniae Infections
Pneumococcal Infections
Infections, Pneumococcal
Infections, Streptococcus pneumoniae
Pneumococcal Diseases

Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.


Polyanethol Sulfonate
Sodium Polyanetholesulfonate
Polyanetholesulfonate
Polyanetholesulfonate Homopolymer
Liquoid

A compound originally developed as an anticoagulant, but possessing anticomplement action and lowering the bactericidal action of blood. It is used in vitro to inhibit blood coagulation and as a diagnostic reagent to encourage the growth of pathogens in the blood. It is also used to stabilize colloidal solutions such as milk and gelatin. (From Merck Index, 11th ed)


Area Health Education Centers
Area Health Education Center

Education centers authorized by the Comprehensive Health Manpower Training Act, 1971, for the training of health personnel in areas where health needs are the greatest. May be used for centers other than those established by the United States act.


Impaired digestion, especially after eating.


Phosphates
Phosphates, Inorganic
Orthophosphate
Inorganic Phosphates
Phosphate


Hydroxymethylglutaryl-Coenzyme A Reductase (NADP)

3-Hydroxy-3-methylglutaryl-coenzyme A reductase, NADP-dependent

Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of this class are involved in cholesterol biosynthesis.


A species of gram-negative, rod-shaped bacteria belonging to the K serogroup of ESCHERICHIA COLI. It lives as a harmless inhabitant of the human LARGE INTESTINE and is widely used in medical and GENETIC RESEARCH.


Betadexamethasone Celeston Cellestoderm Betamethasone Celestone Flubenisolone Celestona

A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)


Phospholipases A2, Group I
Group I Phospholipases A2

A subcategory of secreted phospholipases A2 that includes enzymes isolated from ELAPID VENOMS and pancreatic sources. The creation of this group is based upon similarities in the structural determinants of the enzymes.


Mastisol
Mastic Resin
Gum Mastic
Mastic Gum

Dried tree sap from the MASTIC TREE that is used in TRADITIONAL MEDICINE and chewed as gum.


Trypanosomiasis, Cardiovascular
Cardiomyopathy, Chagas
Chagas Cardiomyopathy
Myocarditis, Chagas
Chagas' Cardiomyopathy

A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.


The discharge of substances into the TEARS.


Espironolactona Alter
Verospiron
Flumach
Verospirone
Spirogamma
Spirolang
SC-9420
Spironone
Veroshpiron
Jenaspiron
Spironolactone
Spirospare
Spiro Von Ct
Aldactone A
Spirono-Isis
Spirolactone
Spiractin
Spiro L.U.T.
Duraspiron
Novo-Spiroton
Aldactone
Frumikal
Aquareduct
Practon
Spirobeta
Espironolactona Mundogen

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)


Dihydroergotoxine
Dihydroergotoxin
Ergot Alkaloids, Hydrogenated
Co-Dergocrine

A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.


Mitogen-Activated Protein Kinase Phosphatases

A subcategory of phosphohydrolases that are specific for MITOGEN-ACTIVATED PROTEIN KINASES. They play a role in the inactivation of the MAP KINASE SIGNALING SYSTEM.


Squamous Odontogenic Tumor
Odontogenic Tumor, Squamous

A well-differentiated, benign, hamartomatous proliferation of odontogenic epithelium, probably arising from the rests of Malassez.


Scavenger Receptors, Class D
SR-D Proteins

A class of scavenger receptors that are specific for oxidized LOW-DENSITY LIPOPROTEINS and apoptotic cells. They are expressed almost exclusively in INTRACELLULAR MEMBRANES of MACROPHAGES.


Technetium Tc 99m Pyrophosphate, Tc(3+) Salt (3:4)

Technetium Tc 99m Pyrophosphate, Tc(4+) Salt (1:1)

A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.


Lipid-Linked Proteins
Lipid-Anchored Membrane Proteins
Lipid Anchored Proteins
Membrane Lipid-Linked Proteins

Proteins that are covalently-linked to lipid molecules or hydrophobic molecules such as those that contain prenyl groups. The lipid moieties aid in the association of the proteins with CELL MEMBRANES.


(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid (PGA(1)); (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid (PGA(2)); (5Z,13E,15S,17Z)-15-hydroxy-9-oxoprosta-5,10,13,17-tetraen-1-oic acid (PGA(3)). A group of naturally occurring secondary prostaglandins derived from PGE; PGA(1) and PGA(2) as well as their 19-hydroxy derivatives are found in many organs and tissues.


Abdominal Radiography
Radiography, Abdominal

Radiographic visualization of the body between the thorax and the pelvis, i.e., within the peritoneal cavity.


Wild Rutabaga
Field Mustard
Brassica rapa
Wild Turnip

A subspecies of Brassica that includes rape mustard. It is cultivated for the seed and used as animal feed.


3 Oxoacyl (Acyl Carrier Protein) Synthase

beta Keto-Acyl Carrier Protein Synthase II

3-Oxoacyl (Acyl Carrier Protein) Synthase

An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 2.3.1.41.


Lactobacillus sporogenes
Bacillus coagulans

A microaerophilic, LACTIC ACID producing species of Bacillus that occurs in FERMENTED FOODS AND BEVERAGES. It also produces ANTI-INFECTIVE AGENTS and is used as a PROBIOTIC.


Neoplasms of the bony part of the skull.


Factors, Immunologic Suppressor
Suppressor Factors, Immunologic
Suppressor Factor (SF4)
Immunologic Suppressor Factors
Factors, T Suppressor
Suppressor T-Cell Factors
T-Suppressor Factors
T Cell Suppressor Factors
T-Cell Suppressive Factors

Proteins, protein complexes, or glycoproteins secreted by suppressor T-cells that inhibit either subsequent T-cells, B-cells, or other immunologic phenomena. Some of these factors have both histocompatibility (I-J) and antigen-specific domains which may be linked by disulfide bridges. They can be elicited by haptens or other antigens and may be mass-produced by hybridomas or monoclones in the laboratory.


Neurosteroids
Neuro-Steroids
Neurosteroid
Neuro-Steroid
Neuroactive Steroids

Endogenous compounds or drugs that affect neuronal excitability through modulation of specific ionotropic receptors (e.g., GABA-A RECEPTORS). Endogenous neurosteroids are steroid hormones de novo synthesized by neurons and glial cells from steroid metabolite precursors (e.g., PREGNENOLONE).


Chromosomes F
Group F Chromosomes
Chromosomes, Human, 19-20

The short, metacentric human chromosomes, called group F in the human chromosome classification. This group consists of chromosome pairs 19 and 20.


10-carbon saturated monocarboxylic acids.


Transcription Factors
Transcription Factor

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.


A plant genus of the family PYROLACEAE. The common name of wintergreen is more often used for GAULTHERIA.


Pyridine Aldoxime Methyl Compounds
2-PAM Compounds
Pralidoxime Compounds

Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular junction, and may cause neuromuscular blockade. They are used as antidotes to organophosphorus poisoning as chlorides, iodides, methanesulfonates (mesylates), or other salts.


Chairs mounted on wheels and designed to be propelled by the occupant.


Osmolarity
Osmolality
Ionic Strength
Osmolar Concentration

The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.


Surgical Procedures, Thoracic
Procedures, Thoracic Surgical
Surgical Procedure, Thoracic
Procedure, Thoracic Surgical
Thoracic Surgical Procedure
Thoracic Surgical Procedures

Surgery performed on the thoracic organs, most commonly the lungs and the heart.


Dopamine beta-Hydroxylase
Dopamine beta-Monooxygenase


The total of dental diagnostic, preventive, and restorative services provided to meet the needs of a patient (from Illustrated Dictionary of Dentistry, 1982).


ICI-33,828 Methallibure Metallibure Suisynchron Metallibur Turisynchron Aimax

A dithiobiurea compound with anti-gonadotropic activity.


A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].


Adenylate Cyclase
Adenyl Cyclase
3',5'-cyclic AMP Synthetase
Adenylyl Cyclases
Adenylyl Cyclase

Enzymes of the lyase class that catalyze the formation of CYCLIC AMP and pyrophosphate from ATP.


Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.


Oxytocin Receptor
Receptors, Oxytocin
Oxytocin Receptors

Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.


Succinyl CoA Synthetases
Succinate-CoA Ligases
Succinate-CoA Ligase (GDP-Forming)
Succinic Thiokinases
Succinyl Coenzyme A Synthetases
Succinate-CoA Ligases (ADP-Forming)

Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and ITP instead of GTP.EC 6.2.1.-.


An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.


The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation.


Operator Regions, Genetic
Operator Region
Operator Regions
Operator, Genetic

The regulatory elements of an OPERON to which activators or repressors bind thereby effecting the transcription of GENES in the operon.


A group of degraded TRITERPENES in which the four terminal carbons of the C17 side chain have been removed, and the remaining portion often forming C17 furans.


Cartilage-Specific Proteoglycan Core Proteins

Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.


Pasteurella tularensis
Francisella tularensis

The etiologic agent of TULAREMIA in man and other warm-blooded animals.


Disorder characterized by recurrent, intense sexually arousing fantasies, sexual urges, or behaviors involving cross-dressing in a heterosexual male. The fantasies, urges, or behaviors cause clinically significant distress or impairment in social, occupational or other areas of functioning. (from APA, DSM-IV, 1994)


Transcription Factor Brn-3
Brn-3 Transcription Factor

A family of mammalian POU domain factors that are expressed predominately in NEURONS.


An Order of aquatic INSECTS comprising about 2,500 species worldwide. It is the only insect group with two flying stages, each with relatively large forewings. The immature stage called "naiad" or "nymph" lasts one year in fresh water, and the adult stage is shortlived, lasting from a few minutes to a few days, depending on the species. The Ephemeroptera includes mayflies (also called shadflies)


Reference Values
Reference Ranges
Normal Values
Normal Range

The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.


Circadian Clocks
Circadian Timing System
Circadian Clock System

Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.


Thymoanaleptics
Antidepressant Drugs
Antidepressants
Thymoleptics
Antidepressive Agents

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.


A species of the genus VESIVIRUS infecting cats. Transmission occurs via air and mechanical contact.


Low Density Lipoprotein Receptor-Related Protein 5

Low Density Lipoprotein Receptor-Related Protein-5

LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.


Microorganisms, Genetically-Modified
Genetically-Modified Microorganisms

Microorganisms whose GENOME has been altered by GENETIC ENGINEERING.


Fat, Subcutaneous
Adipose Tissue, Subcutaneous
Subcutaneous Adipose Tissue
Subcutaneous Fat

Fatty tissue under the SKIN through out the body.


Receptors, Lipoprotein
Receptors, Lipoproteins
Lipoprotein Receptor
Lipoprotein Receptors

Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.


Acylcholineacylhydrolase Cholinesterase Cholinesterases Cholase


Epidemiologic Method
Epidemiologic Methods
Epidemiological Methods
Methods, Epidemiologic

Research techniques that focus on study designs and data gathering methods in human and animal populations.


Neuroses, Phobic
Phobic Disorders
Phobia, School
Phobias
Phobic Neuroses
Claustrophobia

Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.


Artificial Chromosomes, Bacterial
Bacterial Artificial Chromosomes
Chromosomes, Bacterial Artificial
BAC (Chromosome)
Chromosomes, Artificial, Bacterial
BACs (Chromosomes)

DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.


Sodium-Glucose Transport Proteins
Glucose-Sodium Transport System
Glucose Sodium Transport System
SGLT Proteins
Sodium-Glucose Transport System
Sodium Glucose Cotransporters
Sodium Glucose Transporters
Sodium-Sugar Transporter
Sodium Glucose Transport System

Monosaccharide transport proteins that function as active symporters. They utilize SODIUM or HYDROGEN IONS to transport GLUCOSE across CELL MEMBRANES.


Sinuatrial Node
Sinus Node
Sinu-Atrial Node
Sinoatrial Node
Sino-Atrial Node

The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).


Methods used to label and follow the course of NEURAL PATHWAYS by AXONAL TRANSPORT of injected NEURONAL TRACT-TRACERS.


A gamma-Globin
G gamma-Globin
gamma-Globin
gamma-Globins

A type of gamma-globin encoded by the G gamma globin gene on CHROMOSOME 11.


Interleukin-21 Receptors
IL-21 Receptor
IL-21 Receptors
IL21R
Receptors, Interleukin-21
Interleukin-21 Receptor
Receptor, Interleukin-21

Cell surface receptors for interleukin 21. They are heterodimeric proteins found on DENDRITIC CELLS and LYMPHOCYTES that consist of the INTERLEUKIN-21 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR COMMON BETA SUBUNIT.


Mouse, CFTR
Mice, Inbred CFTR
Mouse, Inbred CFTR
Mice, CFTR

A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.


Pancreas Transplantation
Transplantation, Pancreas
Grafting, Pancreas

The transference of a pancreas from one human or animal to another.


Aqueous-Blood Barrier
Blood-Aqueous Barrier

The selectively permeable barrier, in the EYE, formed by the nonpigmented layer of the EPITHELIUM of the CILIARY BODY, and the ENDOTHELIUM of the BLOOD VESSELS of the IRIS. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.


Cellulosic Acid
Carboxycellulose
Oxycel
Cellulose, Oxidized
Oxycellulose
Absorbable Cellulose

A cellulose of varied carboxyl content retaining the fibrous structure. It is commonly used as a local hemostatic and as a matrix for normal blood coagulation.


Hereditary Thrombophilia Due To Protein C Deficiency

An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)


Health Risk Appraisal
Health Status Indexes
Health Status Index
Health Status Indicators

The measurement of the health status for a given population using a variety of indices, including morbidity, mortality, and available health resources.


Aldehyde Dehydrogenase Blockers
Acetaldehyde Dehydrogenase Antagonists
Acetaldehyde Dehydrogenase Inhibitors

Compounds that bind to and inhibit the enzymatic activity of acetaldehyde dehydrogenases.


Coxsackie and Adenovirus Receptor-Like Membrane Protein

An Ig superfamily transmembrane protein that localizes to junctional complexes that occur between ENDOTHELIAL CELLS and EPTHELIAL CELLS. The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection.


A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain asitrocin, asitrilobins, and other tetrahydrofuran acetogenins.


Tumor Suppressor p53-Binding Protein 1
p202 Protein
Tumor Protein p53-Binding Protein, 1
TP53BP1 Protein
53BP1 Protein

A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.


Stellate Ganglion
Cervicothoracic Ganglion
Stellate Ganglia
Cervicothoracic Ganglia

A paravertebral sympathetic ganglion formed by the fusion of the inferior cervical and first thoracic ganglia.


Horsebean
Bean, Horse
Faba Bean
Bean, Faba
Vicia faba
Fava Bean

A plant species of the genus VICIA, family FABACEAE. The edible beans are well known but they cause FAVISM in some individuals with GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY. This plant contains vicine, convicine, Vicia lectins, unknown seed protein, AAP2 transport protein, and Vicia faba DNA-binding protein 1.


Wave-like oscillations of electric potential between parts of the brain recorded by EEG.


Image Quality Enhancement
Image Enhancement

Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.


Glenoid Fossa of the Scapula
Glenoid Fossa
Glenoid Cavity

A depression in the lateral angle of the scapula that articulates with the HUMERAL HEAD.


Medicine, Palliative
Palliative Care Medicine
Palliative Medicine

A branch of medicine concerned with preventing and relieving the suffering of patients in any stage of disease. Its focus is on comprehensive care and improving the quality of all areas of the patient's life.


Ingestion of a greater than optimal quantity of food.


An infraclass of MAMMALS, also called Metatheria, where the young are born at an early stage of development and continue to develop in a pouch (marsupium). In contrast to Eutheria (placentals), marsupials have an incomplete PLACENTA.


Configuration, Molecular
Molecular Configuration
Three Dimensional Molecular Structure
Molecular Structure, Three Dimensional
Molecular Conformation
3D Molecular Structure

The characteristic three-dimensional shape of a molecule.


A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 7; CASPASE 8; and CASPASE 10. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.


Ecological Community
Biocenose
Biota
Biological Community
Community Composition, Ecological
Community Structure, Ecological
Biotic Community

A technical term that describes the organization of a biological community with respect to ecological interactions. These interactions include competition, mutualism, predation, and commensalism.


SLC2A5 Protein
Glucose Transporter Type 5
GLUT-5 Protein
GLUT5 Protein
D-Fructose Transporter

A hexose transporter that mediates FRUCTOSE transport in SKELETAL MUSCLE and ADIPOCYTES and is responsible for luminal uptake of dietary fructose in the SMALL INTESTINE.


Synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.


A pumping mechanism that duplicates the output, rate, and blood pressure of the natural heart. It may replace the function of the entire heart or a portion of it, and may be an intracorporeal, extracorporeal, or paracorporeal heart. (Dorland, 28th ed)


Canine Hip Dysplasia
Hip Dysplasia, Canine

A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.


NG-Monomethyl-L-Arginine
N(omega)-Monomethyl-L-Arginine
N(G)-Monomethyl-D-Arginine
N(G)-Methylarginine
L-Monomethylarginine
L-NG-Monomethyl Arginine
omega-N-Methylarginine
D-NMMA
N(G)-Monomethylarginine
L-NMMA

A competitive inhibitor of nitric oxide synthetase.


Mutansucrase
Sucrose alpha-D-Glucohydrolase
Sucrase

Digestive enzyme secreted in the INTESTINES. It catalyzes hydrolysis of SUCROSE to FRUCTOSE and GLUCOSE.


Pharmacological and Toxicological Processes

Pharmacological and Toxicological Phenomena

Pharmacological and Toxicological Concepts

Synthesis, metabolism, and poisoning associated with drugs, pharmaceuticals, and other active molecules. Toxicological phenomena also include the adverse effects of physical phenomena such as RADIATION and NOISE.


A genus of flagellate protozoans found in the BLOOD and LYMPH of vertebrates and invertebrates, both hosts being required to complete the life cycle.


Minichromosome Maintenance Complex Component 6

A minichromosome maintenance protein that is a key component of the six member MCM protein complex. It is also found in tightly-bound trimeric complex with MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 4 and MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 7.


Zygotes, Plant
Embryos, Plant
Plant Zygotes
Seeds
Plant Embryos

The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.


Unwanted Births
Child, Unwanted
Unwanted Children

The child who is not wanted by one or both parents.


HLA Class I Histocompatibility Antigen, A-2 alpha Chain

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.


Dextro-Looped Transposition of the Great Arteries

A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.


An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.


Solute Carrier Family 12 (Potassium Chloride Transporters), Member 4 Protein

Electroneutral Potassium-Chloride Cotransporter 1

K-Cl cotransporter ubiquitously expressed with higher expression levels in ERYTHROCYTES of ANEMIA, SICKLE CELL. It mediates active potassium and chloride cotransport across the plasma membrane and contributes to cell volume homeostasis


Injections, Intramuscular
Intramuscular Injections

Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.


Annelids of the class Hirudinea. Some species, the bloodsuckers, may become temporarily parasitic upon animals, including man. Medicinal leeches (HIRUDO MEDICINALIS) have been used therapeutically for drawing blood since ancient times.


Affiliation, Organizational
Organizational Affiliation

Formal relationships established between otherwise independent organizations. These include affiliation agreements, interlocking boards, common controls, hospital medical school affiliations, etc.


Oxyurida Infections
Infections, Oxyurida

Infections with nematodes of the order OXYURIDA.


Fractures in which there is an external wound communicating with the break of the bone.


A set of cognitive functions that controls complex, goal-directed thought and behavior. Executive function involves multiple domains, such as CONCEPT FORMATION, goal management, cognitive flexibility, INHIBITION control, and WORKING MEMORY. Impaired executive function is seen in a range of disorders, e.g., SCHIZOPHRENIA; and ADHD.


Puerperal Infection
Postpartum Sepsis
Infection, Puerperal

An infection occurring in PUERPERIUM, the period of 6-8 weeks after giving birth.


Stereopsis
Stereoscopic Vision
Depth Perception


Organum Vasculosum of Lamina Terminalis
Supraoptic Crest
Organum Vasculosum
Organum Vasculosum Laminae Terminalis

Circumventricular cellular structure in the anterior hypothalamic region. It is located in the optic recess at the anteroventral end of the THIRD VENTRICLE and forms the ventral part of the midline anterior wall.


Emotional, psychological, and social well-being of an individual or group.


A plant genus of the family CARYOPHYLLACEAE that contains ALLANTOIN and a ribosome-inactivating protein.


An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.


CNTF Receptor
Ciliary Neurotrophic Factor Receptor
Receptor, Ciliary Neurotrophic Factor

Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).


Axolotl
Mexican Salamander
Ambystoma mexicanum

A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.


4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.


HLA Class II Histocompatibility Antigen, DR beta Chain

Transmembrane proteins that form the beta subunits of the HLA-DR antigens. They are also referred to as the HLA-DR light chains.


Double-Stranded DNA Breaks
DNA Breaks, Double-Stranded
Double-Strand DNA Breaks
Double-Stranded DNA Break

Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.


Chicken Ovalbumin Upstream Promoter-Transcription Factors

A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.


Cruciate Ligament, Posterior
Posterior Cruciate Ligament

A strong ligament of the knee that originates from the anterolateral surface of the medial condyle of the femur, passes posteriorly and inferiorly between the condyles, and attaches to the posterior intercondylar area of the tibia.


Hebiatrics
Ephebiatrics
Adolescent Medicine
Medicine, Adolescent

A branch of medicine pertaining to the diagnosis and treatment of diseases occurring during the period of ADOLESCENCE.


Chromosomal Position Effect
Position Effect Variegation
Chromosomal Position Effects

Cell to cell variation in gene expression caused by chromosomal position effects.


Gene Rearrangement, B-Lymphocyte
Gene Rearrangement, B-Cell
B-Cell Gene Rearrangement
B-Lymphocyte Gene Rearrangement

Ordered rearrangement of B-lymphocyte variable gene regions coding for the IMMUNOGLOBULIN CHAINS, thereby contributing to antibody diversity. It occurs during the differentiation of the IMMATURE B-LYMPHOCYTES.


P450 CYP1A2 Inducers
CYP1A2 Inducers
Cytochrome P-450 CYP1A2 Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP1A2.


An enzyme localized predominantly within the plasma membrane of lymphocytes. It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. EC 2.3.1.23.


Excretion of an excessive amount of OXALATES in the urine.


An RNA-DNA hybrid structure formed when newly transcribed RNA remains bound to its DNA template. Stability of R-loops may play a role in GENETIC INSTABILITY.


Procedures, Vascular Surgical
Surgical Procedures, Vascular
Vascular Surgical Procedures
Vascular Surgical Procedure
Surgical Procedure, Vascular
Procedure, Vascular Surgical

Operative procedures for the treatment of vascular disorders.


Glutamic-Alanine Transaminase
Alanine Transaminase
Alanine-2-Oxoglutarate Aminotransferase
Glutamic-Pyruvic Transaminase
SGPT
Alanine Aminotransferase

An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.