Secondary Protein Structure
Protein Structure, Secondary

The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to ALPHA-HELICES; BETA-STRANDS (which align to form BETA-SHEETS), or other types of coils. This is the first folding level of protein conformation.


Nursing, Medical Surgical
Medical-Surgical Nursing
Nursing, Medical-Surgical
Medical Surgical Nursing

The area of nursing concerned with the needs and care of adult medical and surgical patients.


Invasion of a wound by pathogenic microorganisms.


Acute Mesenteric Arterial Embolus
Occlusive Mesenteric Arterial Ischemia
Mesenteric Vascular Insufficiency
Mesenteric Venous Thrombosis
Mesenteric Ischemia
Acute Mesenteric Arterial Thrombosis
Nonocclusive Mesenteric Ischemia

Ischemic tissue injury produced by insufficient perfusion of intestinal tissue by the MESENTERIC CIRCULATION (i.e., CELIAC ARTERY; SUPERIOR MESENTERIC ARTERY; INFERERIOR MESENTERIC ARTERY; and MESENTERIC VEINS). It can progress from ISCHEMIA; EDEMA; and GANGRENE of the bowel wall to PERITONITIS and cardiovascular collapse.


Surgical Site Infection
Wound Infection, Surgical
Infection, Postoperative Wound
Surgical Wound Infection
Infection, Surgical Wound
Postoperative Wound Infection
Wound Infection, Postoperative

Infection occurring at the site of a surgical incision.


DNA (Cytosine-5-)-Methyltransferase 1
DNMT1 Enzyme

A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.


The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)


Hemolytic Uremic Syndrome, Atypical
Nonenteropathic HUS
Non-Stx-Hus
Non-Shiga-Like Toxin-Associated HUS
Atypical Hemolytic-Uremic Syndrome
Atypical Hemolytic Uremic Syndrome

An hereditary hemolytic uremic syndrome associated with variations in the gene that encodes COMPLEMENT FACTOR H, or the related proteins CFHR1 and CFHR3. Disease often progresses to CHRONIC KIDNEY FAILURE without the prodromal symptoms of ENTEROCOLITIS and DIARRHEA that characterize typical hemolytic uremic syndrome.


Abufène
L-Alanine
Alanine, L-Isomer
Alanine

A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.


C3PAse
28 kDa Protein, Adipocyte
Factor D
Complement Protein D
D Component of Complement
C3 Proactivator Convertase
Properdin Factor D
Proactivator Convertase
C3 Convertase Activator
Adipsin
GBGase
C3PA Convertase
Complement Factor D

A serum protein which is important in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. This enzyme cleaves the COMPLEMENT C3B-bound COMPLEMENT FACTOR B to form C3bBb which is ALTERNATIVE PATHWAY C3 CONVERTASE.


Hyperplasia, Congenital Adrenal
Congenital Adrenal Hyperplasia
Adrenal Hyperplasia, Congenital

A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.


Abortion, Illegal
Illegal Abortion
Abortion, Criminal


Basal Ganglia Disorders
Basal Ganglia Diseases
Extrapyramidal Disorders
Lenticulostriate Disorders

Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.


Leptospirosis, Icterohemorrhagic
Weil Disease
Jaundice, Spirochetal
Weil's Disease

A severe form of LEPTOSPIROSIS, usually caused by LEPTOSPIRA INTERROGANS SEROVAR ICTEROHAEMORRHAGIAE and occasionally other serovars. It is transmitted to humans by the rat and is characterized by hemorrhagic and renal symptoms with accompanying JAUNDICE.


zeta-Crystallin
Crystallins, zeta
zeta Crystallin-NADPH Oxidoreductase
zeta-Crystallins

A group of crystallins that have been found in the lens (LENS, CRYSTALLINE) of certain species of VERTEBRATES including GUINEA PIGS; CAMELS; and LLAMAS. They are inactivated forms of NAD(P)H DEHYDROGENASE (QUINONE).


A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.


Prostaglandins E, Synthetic
Prostaglandin E Analogues
Synthetic Prostaglandins E
Prostaglandin E Analogs
PGE Synthetic

Analogs or derivatives of prostaglandins E that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE.


Chromosomes, Human, Pair 22
Chromosome 22

A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.


Boeck's Disease
Besnier-Boeck Disease
Schaumann's Syndrome
Besnier-Boeck-Schaumann Syndrome
Schaumann Syndrome
Schaumann Disease
Boeck Disease
Sarcoidosis
Boeck's Sarcoid

An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.


Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.


Manatee, Caribbean
Manatee, Florida
Caribbean Manatee
Trichechus manatus
Manatee, West Indian
West Indian Manatee
Florida Manatee

Member of the genus Trichechus inhabiting the coast and coastal rivers of the southeastern United States as well as the West Indies and the adjacent mainland from Vera Cruz, Mexico to northern South America. (From Scott, Concise Encyclopedia Biology, 1996)


RNA, Ribosomal, 18S
18S Ribosomal RNA
18S RRNA

Constituent of the 40S subunit of eukaryotic ribosomes. 18S rRNA is involved in the initiation of polypeptide synthesis in eukaryotes.


Thymine Nucleotides
Thymidine Phosphates

Phosphate esters of THYMIDINE in N-glycosidic linkage with ribose or deoxyribose, as occurs in nucleic acids. (From Dorland, 28th ed, p1154)


Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.


Anti-Sense DNA
DNA, Antisense
Antisense DNA

DNA that is complementary to the sense strand. (The sense strand has the same sequence as the mRNA transcript. The antisense strand is the template for mRNA synthesis.) Synthetic antisense DNAs are used to hybridize to complementary sequences in target RNAs or DNAs to effect the functioning of specific genes for investigative or therapeutic purposes.


Tsimarin Cymarin k-Strophanthin-alpha Cymarine Strophantisel h-Strophanthin Zimarin

A cardiotonic cardiac glycoside found in STROPHANTHUS. The aglycone is STROPHANTHIN.


Leukodystrophy with Rosenthal Fibers
Demyelinogenic Leukodystrophy
Alexander Disease
Dysmyelinogenic Leukodystrophy
Alexander's Disease
Fibrinoid Degeneration of Astrocytes

Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.


Adrenergic beta-1 Agonists
Adrenergic beta1-Agonists
Adrenergic beta-1 Receptor Agonists
Adrenergic beta-1 Receptor Agonist

Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS.


GP-39 Protein
Cartilage Glycoprotein 39
CHI3L1 Protein
YLK-40 Protein
Chitinase-3-Like Protein 1
CGP-39 Protein

A lectin that binds CHITIN, but lacks chitinase activity. It may be involved in tissue remodeling and cellular responses to the environment, including the response of type 2 HELPER T-CELLS to INFLAMMATION and sensitization to ALLERGENS. Mutations in the CHI3L1 gene are associated with ASTHMA.


Glycoprotein GP-2
Merosin
Laminin M
Laminin
Laminin M Chain

Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.


Craniomandibular Diseases
Craniomandibular Disorders

Diseases or disorders of the muscles of the head and neck, with special reference to the masticatory muscles. The most notable examples are TEMPOROMANDIBULAR JOINT DISORDERS and TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME.


Pyridoxine Kinase
Pyridoxamine Kinase
Pyridoxal Kinase
Pyridoxal Phosphokinase

An enzyme that catalyzes reversibly the phosphorylation of pyridoxal in the presence of ATP with the formation of pyridoxal 5-phosphate and ADP. Pyridoxine, pyridoxamine and various derivatives can also act as acceptors. EC 2.7.1.35.


H-Protein, Glycine Decarboxylase Complex

A LIPOIC ACID-containing protein that plays the pivotal role in the transfer of methylamine groups and reducing equivalents between the three enzymatic components of the glycine decarboxylase complex.


Drug Information Services
Information Services, Drug
Services, Drug Information

Services providing pharmaceutic and therapeutic drug information and consultation.


Hospital Laundry Service
Service, Hospital Laundry
Laundry Service, Hospital

Hospital department which administers all activities pertaining to the hospital laundry service.


Bullous Congenital Ichthyosiform Erythroderma

Congenital Ichthyosiform Erythroderma, Bullous

Congenital Bullous Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma Congenital

Ichthyosiform Erythroderma, Bullous Congenital

Bullous Erythroderma Ichthyosiformis Congenita of Brocq

A form of congenital ichthyosis inherited as an autosomal dominant trait and characterized by ERYTHRODERMA and severe hyperkeratosis. It is manifested at birth by blisters followed by the appearance of thickened, horny, verruciform scales over the entire body, but accentuated in flexural areas. Mutations in the genes that encode KERATIN-1 and KERATIN-10 have been associated with this disorder.


A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.


Hyaglosidase
Hyaluronidase
Duran-Reynals Permeability Factor
Hyaluronate Hydrolase
Hyaluronoglucosaminidase
Wydase
GL Enzyme

An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.


Psychological Feedback
Feedback, Psychological

A mechanism of information stimulus and response that may control subsequent behavior, cognition, perception, or performance. (From APA Thesaurus of Psychological Index Terms, 8th ed.)


Retinol-Binding Proteins, Plasma
Plasma Retinol-Binding Proteins

Retinol binding proteins that circulate in the PLASMA. They are members of the lipocalin family of proteins and play a role in the transport of RETINOL from the LIVER to the peripheral tissues. The proteins are usually found in association with TRANSTHYRETIN.


Apo-Oxaprozin
Oxaprozin
Rhoxal-oxaprozin
Wy-21,743
Danoprox
4,5-Diphenyl-2-oxazolepropionic Acid
Daypro
Dayrun

An oxazole-propionic acid derivative, cyclooxygenase inhibitor, and non-steroidal anti-inflammatory drug that is used in the treatment of pain and inflammation associated with of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; and ARTHRITIS, JUVENILE.


A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)


Methylglycine
Sarcosine
Sodium Sarcosinate
Sarcosine Hydrochloride
Sarcosine Monosodium Salt
Magnesium Sarcosylate
N-Methylglycine

An amino acid intermediate in the metabolism of choline.


Myasthenic-Myopathic Syndrome of Lambert-Eaton

Myopathic-Myasthenic Syndrome of Eaton-Lambert

Myasthenic-Myopathic Syndrome of Eaton-Lambert

Myopathic-Myasthenic Syndrome of Lambert-Eaton

An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)


Mental attitude that interprets life events as generally being negative.


Colonic Diverticula
Diverticula, Colon
Colonic Diverticulum
Diverticulum, Colon
Colon Diverticula


Lipid Droplet Associated Proteins
Lipid Droplet Coat Proteins
Lipid Droplet Proteins

Proteins, such as PERILIPINS, that localize to LIPID DROPLETS either transiently or constitutively.


A structure, situated close to the intraventricular foramen, which induces DRINKING BEHAVIOR after stimulation with ANGIOTENSIN II.


National Longitudinal Study of Adolescent Health

Longitudinal study of a nationally representative sample of adolescents in grades 7-12 in the United States during the 1994-95 school year. The Add Health cohort has been followed into young adulthood. (from http://www.cpc.unc.edu/projects/addhealth accessed 08/2012)


Scopoletin
Chrysotropic Acid
Gelseminic Acid
Methylesculetin

Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica.


Remittent Fever
Infections, Plasmodium
Paludism
Malaria
Plasmodium Infections
Marsh Fever

A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.


rev Gene Products, Human Immunodeficiency Virus

Proteins encoded by the REV GENES of the HUMAN IMMUNODEFICIENCY VIRUS.


Polynucleotide 5'-Hydroxyl-Kinase
DNA Kinase
DNA 5'-Hydroxylkinase
Polynucleotide Kinase
Polynucleotide Hydroxykinase
Polynucleotide Hydroxylkinase
Polynucleotide 5'-Hydroxyl Kinase
5'-Hydroxylpolynucleotide Kinase

An enzyme that catalyzes the transfer of a phosphate group to the 5'-terminal hydroxyl groups of DNA and RNA. EC 2.7.1.78.


Molecular Sequencing Data
Sequence Data, Molecular
Molecular Sequence Data

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.


Catastrophizing
Catastrophization
Pain Catastrophizing

Cognitive and emotional processes encompassing magnification of pain-related stimuli, feelings of helplessness, and a generally pessimistic orientation.


Platelet Glycoprotein GPIIb-IIIa Complex

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.


A genus of long-legged, swift-moving felines (FELIDAE) from Africa (and formerly Asia) about the size of a small leopard.


2-Methyl-5-nitroimidazole-1-ethanol
Metronidazole Phosphoester
Vagilen
MetroGel
Metrodzhil
Trichopol
Trivazol
Flagyl
Satric
Gineflavir
Metrogyl
Metric
Metronidazole Monohydrochloride
Clont
Metronidazole
Bayer 5360
Danizol
Trichazol
Metronidazole Hydrochloride
Metronidazole Phosphate

A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.


Allocells
Allogeneic Cells
Homologous Cells

Cells from genetically different individuals of the same species to be used for CELL- AND TISSUE-BASED THERAPY; ADOPTIVE CELL TRANSFER; or ADOPTIVE IMMUNOTHERAPY.


Dental Enamel Permeability
Enamel Permeability, Dental
Permeability, Dental Enamel

The property of dental enamel to permit passage of light, heat, gases, liquids, metabolites, mineral ions and other substances. It does not include the penetration of the dental enamel by microorganisms.


Killer Cell Immunoglobulin-Like Receptor 2DL5

An inhibitory KIR receptor that contains D0 and D1 extracellular immunoglobulin-like domains and a long cytoplasmic tail.


Remission Induction
Induction of Remission

Therapeutic act or process that initiates a response to a complete or partial remission level.


Spectrophotometry, Ultraviolet
Ultraviolet Spectrophotometry

Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


The type (and only) species of RUBIVIRUS causing acute infection in humans, primarily children and young adults. Humans are the only natural host. A live, attenuated vaccine is available for prophylaxis.


Prostaglandin F2alpha
Prostaglandin F2
Prostaglandin F2 alpha
9alpha,11beta-PGF2
Enzaprost F
PGF2
Dinoprost
PGF2 alpha
Estrofan
PGF2alpha

A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.


A small leucine-rich proteoglycan that contains 4 KERATAN SULFATE chains within the leucine repeat region. It interacts with COLLAGEN TYPE I and COLLAGEN TYPE II fibrils and may function to control the rate of EXTRACELLULAR MATRIX assembly. It also sequesters TRANSFORMING GROWTH FACTOR BETA in the extracellular matrix.


Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.


Bacteriophage PRD1
Phage PRD1
Enterobacteria phage PRD1

Bacteriophage and type species in the genus Tectivirus, family TECTIVIRIDAE. They are specific for Gram-negative bacteria.


Phylloquinone
Phytonadione
Konakion
Aquamephyton
Vitamin K 1
Vitamin K1
Phytomenadione
Phyllohydroquinone

A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.


Arch, Dental
Dental Arches
Dental Arch
Arches, Dental

The curve formed by the row of TEETH in their normal position in the JAW. The inferior dental arch is formed by the mandibular teeth, and the superior dental arch by the maxillary teeth.


The use of light to convert ADP to ATP without the concomitant reduction of dioxygen to water as occurs during OXIDATIVE PHOSPHORYLATION in MITOCHONDRIA.


A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.


Polymorphonuclear Leukocyte Elastase
Leukocyte Elastase
Granulocyte Elastase
Lysosomal Elastase
Neutrophil Elastase
PMN Elastase

An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.


Bibliographies as Topic
Bibliography as Topic

Works about lists of books, articles, and other publications.


An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, SARCOPHAGIDAE, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).


Moraxella catarrhalis
Branhamella catarrhalis
Moraxella (Branhamella) catarrhalis

Gram-negative aerobic cocci of low virulence that colonize the nasopharynx and occasionally cause MENINGITIS; BACTEREMIA; EMPYEMA; PERICARDITIS; and PNEUMONIA.


Natural analogs of TOCOPHEROLS exhibiting antioxidant activity. These tocol derivatives and isomers contain a benzopyran ring and an unsaturated isoprenoid side chain.


Nek1 Kinase
NIMA-Related Kinase 1
NIMA-Related Protein Kinase 1
Nek1 Protein Kinase

A NIMA-related kinase that functions in CELL CYCLE regulation, the control of CILIA assembly, and CENTROSOME duplication. It is activated at G2 PHASE CELL CYCLE CHECKPOINTS in response to DNA DAMAGE.


Salmonella enterica serovar Paratyphi C
Salmonella hirschfeldii
Salmonella paratyphi C

A serotype of SALMONELLA ENTERICA which is an agent of PARATYPHOID FEVER in Asia, Africa, and southern Europe.


Lectin, Galactoside-Binding, Soluble, 4 Protein

A galectin found in the small and large intestine and the stomach. It occurs as a homodimer with two 36-kDa subunits and is localized to sites of cell adhesion where it may play role in assembly of ADHERENS JUNCTIONS.


Surital
Thiamylal Sodium
Thiamylal
Thioquinalbarbitone

A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)


Nurses Improving Care for Healthsystem Elders.

Nurses Improving Care for Health System Elders

Nonprofit programs designed to address the complex needs of older adults and improve outcomes. They provide the principles, education and tools to support healthcare systems in transforming and achieving patient-centered care.


Ocular Administration
Administration, Ophthalmic
Administration, Ocular

Application of pharmaceutically active agents on the tissues of the EYE.


2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.


Ascending Colon
Colon, Ascending
Hepatic Flexure
Right Colic Flexure

The segment of LARGE INTESTINE between the CECUM and the TRANSVERSE COLON. It passes cephalad from the cecum to the caudal surface of the right lobe of the LIVER where it bends sharply to the left, forming the right colic flexure.


Serotonin N-Acetyltransferase
Arylalkylamine N-Acetyltransferase
Serotonin Acetylase
Serotonin Acetyltransferase

An acetyltransferase with specificity towards the amine group of aromatic alkylamines (arylalkylamines) such as SEROTONIN. This enzyme is also referred to as serotonin acetylase despite the fact that serotonin acetylation can also occur through the action of broad specificity acetyltransferases such as ARYLAMINE N-ACETYLTRANSFERASE.


Late-Onset Disorders
Later Onset Disorders
Late Onset Disorders
Late Onset Diseases

Pathological conditions (Disorder, SYNDROME, or DISEASE) whose SIGNS AND SYMPTOMS manifest late in the life of an individual.


Oleanolic Acid
Oleanol
Hederins
Oleanane Triterpenes

Pentacyclic triterpenes that are derivatives of beta-amyrin and are the biosynthetic source of GLYCYRRHIZIC ACID and ESCIN.


Money owed to creditors outside of a country.


The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.


NSC-6396
Thio-Tepa
Tris(1-aziridinyl)phosphine Sulfide
Girostan
Tespa
Triethylenethiophosphoramide
AI3-24916
Thiophosphamide
Tespamin
Thiotepa

A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).


Triphenylmethyl Compounds
Trityl Compounds


Kelch-Like ECH-Associated Protein 1
KEAP-1 Protein
KEAP1 Protein

An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.


Vibrio cholerae O139
Vibrio cholerae Serogroup O139

Strains of VIBRIO CHOLERAE containing O ANTIGENS group 139. This strain emerged in India in 1992 and caused a CHOLERA epidemic.


Pre-B-Cell Leukemia Transcription Factor 1

A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.


Ti Plasmid, Agrobacterium tumefaciens
Plant Tumor-Inducing Plasmids
Ti Plasmids

Plasmids coding for proteins which induce PLANT TUMORS. The most notable example of a plant tumor inducing plasmid is the Ti plasmid found associated with AGROBACTERIUM TUMEFACIENS.


Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.


alpha Glycerol-3-Phosphate Dehydrogenase (NAD+)

Glycerol 3-Phosphate Dehydrogenase (NAD+)

An NAD-dependent enzyme that catalyzes the oxidation of sn-glycerol 3-phosphate to glycerone phosphate.


A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.


Ferric Saccharate
Iron(III)-Hydroxide Sucrose Complex
Venofer
D-Glucaric acid, iron(2+) salt (1:1)
Iron Oxide (Saccharated)
Hippiron
Ferri-Saccharate
Ferric Oxide, Saccharated
Iron-Saccharate
Iron Sucrose

A glucaric acid-iron conjugate that is used in the treatment of IRON-DEFICIENCY ANEMIA, including in patients with chronic kidney disease, when oral iron therapy is ineffective or impractical.


The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing.


A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.


Carcinoid
Argentaffinoma
Carcinoid, Goblet Cell
Carcinoid Tumor

A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)


Congenital Subglottic Stenosis
Acquired Laryngeal Stenosis
Laryngeal Stenosis
Acquired Subglottic Stenosis
Laryngostenosis

Developmental or acquired stricture or narrowing of the LARYNX. Symptoms of respiratory difficulty depend on the degree of laryngeal narrowing.


Choanoflagellata Choanozoa Choanoflagellida Choanoflagellates

An order of stalked, sessile, single-celled EUKARYOTES. They are considered the transitional link between the flagellated protozoa and the SPONGES, the most primitive metazoans.


Nucleus Entopeduncularis
Endopeduncular Nucleus
Entopeduncular Nucleus
Nucleus Endopeduncularis

A portion of the nucleus of ansa lenticularis located medial to the posterior limb of the internal capsule, along the course of the ansa lenticularis and the inferior thalamic peduncle or as a separate nucleus within the internal capsule adjacent to the medial GLOBUS PALLIDUS (NeuroNames, http://rprcsgi.rprc. washington.edu/neuronames/ (September 28, 1998)). In non-primates, the entopeduncular nucleus is analogous to both the medial globus pallidus and the entopeduncular nucleus of human.


NF-kappaB 50-kDa
NF-kappa B p50
NFKB1 Transcription Factor
NF-kappa B p105 Precursor Protein
NF-kappa B p50 Subunit

NF-kappa B p105 precursor protein is constitutively processed by the PROTEASOME to produce NF-kappa B p50 subunit. It helps regulate map kinase signaling through its association with Map3k8 protein.


The dry cells of any suitable strain of SACCHAROMYCES CEREVISIAE or CANDIDA. It can be obtained as a by-product from the brewing of beer or by growing on media not suitable for beer production. Dried yeast serves as a source of protein and VITAMIN B COMPLEX.


An ecosystem dominated by coniferous forests including the tree line bordered by TUNDRA to the north and STEPPE to the south.


Meballymal
Seconal Sodium
Seconal
Sebar
Secobarbital Sodium
Secobarbital
Quinalbarbitone

A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.


Response Element, Vitamin D
Vitamin D Response Element

A DNA sequence that is found in the promoter region of vitamin D regulated genes. Vitamin D receptor (RECEPTOR, CALCITRIOL) binds to and regulates the activity of genes containing this element.


An order of heteroxenous protozoa in which the macrogamete and microgamont develop independently. A conoid is usually absent.


Lysergic Acid Diethylamide
Lysergide
LSD
Lysergic Acid Diethylamide Tartrate
LSD-25

Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.


Shoulder Dislocation
Glenohumeral Subluxation
Glenohumeral Dislocation

Displacement of the HUMERUS from the SCAPULA.


Celiac Artery Stenosis from Compression by Median Arcuate Ligament of Diaphragm

Compression of the CELIAC ARTERY by the median arcuate ligament, a fibrous band of the DIAPHRAGM, causing abdominal pain after eating and weight loss. OMIM: 116870


Data recorded by nurses concerning the nursing care given to the patient, including judgment of the patient's progress.


Divinyl Ether Maleic Anhydride Copolymer

Copolymer of divinyl ether and maleic anhydride that acts as an immunostimulant with antineoplastic and anti-infective properties. It is used in combination with other antineoplastic agents.


Genes, TP53
Genes, p53
TP53 Genes
p53 Genes

Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.


Valve Incompetence, Pulmonary
Incompetence, Pulmonary Valve
Pulmonary Valve Insufficiency
Pulmonary Valve Regurgitation
Valve Insufficiency, Pulmonary
Pulmonary Regurgitation
Regurgitation, Pulmonary
Regurgitation, Pulmonary Valve
Valve Regurgitation, Pulmonary
Pulmonary Valve Incompetence
Insufficiency, Pulmonary Valve

Backflow of blood from the PULMONARY ARTERY into the RIGHT VENTRICLE due to imperfect closure of the PULMONARY VALVE.


Myeloid Leukemia, Schilling-Type
Leukemia, Myeloid, Schilling-Type
Monoblastic Leukemia, Acute
Leukemia, Acute Monocytic
Myeloid Leukemia, Acute, M5
Leukemia, Myeloid, Acute, M5
Monocytic Leukemia, Acute
Leukemia, Myeloid, Schilling Type
Leukemia, Monoblastic, Acute
Leukemia, Monocytic, Acute

An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.


Immune Reconstitution Inflammatory Syndrome

Exuberant inflammatory response towards a previously acquired or undiagnosed opportunistic infection. It is frequently seen in AIDS patients following antiretroviral treatment.


Tannerella forsythia ATCC 43037
Bacteroides forsythus ATCC 43037
Bacteroides forsythus
Tannerella forsythia

A periodontal pathogen which is a gram-negative member of BACTEROIDETES. It is implicated in PERIODONTITIS.


Carisoprodol
Soprodol
Mio Relax
Vanadom
Isobamate
Isopropylmeprobamate
Somalgit
Carisoma
Isomeprobamate
Carisoprodate
Soma

A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)


Ciliary Neurotrophic Factor
CNTF
Ciliary Neuronotrophic Factor

A neurotrophic factor that promotes the survival of various neuronal cell types and may play an important role in the injury response in the nervous system.


Ascites, Gelatinous
Pseudomyxoma Peritonei
Syndrome of Pseudomyxoma Peritonei
Gelatinous Ascites

A condition characterized by poorly-circumscribed gelatinous masses filled with malignant mucin-secreting cells. Forty-five percent of pseudomyxomas arise from the ovary, usually in a mucinous cystadenocarcinoma (CYSTADENOCARCINOMA, MUCINOUS), which has prognostic significance. Pseudomyxoma peritonei must be differentiated from mucinous spillage into the peritoneum by a benign mucocele of the appendix. (Segen, Dictionary of Modern Medicine, 1992)


Inflammation of the extraocular muscle of the eye. It is characterized by swelling which can lead to ischemia, fibrosis, or ORBITAL PSEUDOTUMOR.


Interferon-Stimulated Gene Factor 3, alpha Subunit

A heterodimeric complex of STAT1 PROTEIN and STAT2 PROTEIN that interacts with ISGF3GAMMA and is a subunit of the ISGF3 COMPLEX.


Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the SINOATRIAL NODE to the HEART ATRIA. It is characterized by a delayed in heartbeat and pauses between P waves in an ELECTROCARDIOGRAM.


Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.


Appendages of the UTERUS which include the FALLOPIAN TUBES, the OVARY, and the supporting ligaments of the uterus (BROAD LIGAMENT; ROUND LIGAMENT).


Roman Catholic Ethics
Roman Catholics
Catholicism
Roman Catholicism

The Christian faith, practice, or system of the Catholic Church, specifically the Roman Catholic, the Christian church that is characterized by a hierarchic structure of bishops and priests in which doctrinal and disciplinary authority are dependent upon apostolic succession, with the pope as head of the episcopal college. (From Webster, 3d ed; American Heritage Dictionary, 2d college ed)


Public Health Nurses
Nurses, Public Health

Nurses whose goal is to improve health and quality of life in a population or community through the prevention and treatment of disease and other physical and mental health conditions, the surveillance of cases and health indicators, and the promotion of healthy behaviors through public education and awareness.


Mitochondrial Genome
Genome, Mitochondrial

The genetic complement of MITOCHONDRIA as represented in their DNA.


Acute Lymphoblastic Leukemia Cells Antigen CD38

A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.


An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.


The region in the hindlimb of a quadruped, corresponding to the human ANKLE.


An enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphate. EC 5.4.2.2.


Subarachnoid Hemorrhage, Aneurysmal
Perinatal Subarachnoid Hemorrhage
Subarachnoid Hemorrhage, Intracranial
Subarachnoid Hemorrhage, Spontaneous
Subarachnoid Hemorrhage
SAH (Subarachnoid Hemorrhage)
Hemorrhage, Subarachnoid

Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.


Adult Survivors of Childhood Trauma
Adult Survivors of Child Adverse Events

Persons who experienced traumatic events during childhood.


Sulfadimezine Sulfadimidine Sulphamezathine Sulfamethazine

A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.


Genetic Variation
Variation, Genetic
Genetic Diversity
Diversity, Genetic

Genotypic differences observed among individuals in a population.


LIM Kinase
LIM-Kinase
LIM Motif-Containing Protein Kinases
Lim Kinases

Serine protein kinases involved in the regulation of ACTIN polymerization and MICROTUBULE disassembly. Their activity is regulated by phosphorylation of a threonine residue within the activation loop by intracellular signaling kinases such as P21-ACTIVATED KINASES and by RHO KINASE.


A plant genus of the family CUPRESSACEAE. Members contain taxodione and taxodone, which are diterpenoid quinone methide tumor inhibitors.


Technology, Pharmacy
Pharmaceutic Technology
Pharmaceutical Technology
Technology, Pharmaceutic
Pharmacy Technology
Technology, Pharmaceutical

The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.


Filarial infection of the eyes transmitted from person to person by bites of Onchocerca volvulus-infected black flies. The microfilariae of Onchocerca are thus deposited beneath the skin. They migrate through various tissues including the eye. Those persons infected have impaired vision and up to 20% are blind. The incidence of eye lesions has been reported to be as high as 30% in Central America and parts of Africa.


Opium Abuse
Opium Dependence
Opium Use
Opium Addiction
Opium Smoking

Strong physiological and emotional dependence on OPIUM.


Cytochrome P-450 LM(4)
Phenacetin O-Dealkylase
Cytochrome P-450 CYP1A2
Caffeine Demethylase
Cytochrome P-450d
Cytochrome P450 1A2
CYP 1A2
CYP1A2
Cytochrome P-450 LM4

A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.


Social Reinforcement
Reinforcement, Social

The strengthening of a response with a social reward such as a nod of approval, a parent's love or attention.


Clostridium botulinum type E
Clostridium botulinum E

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type E which is neurotoxic to humans and animals.


Zoster Vaccine
Zostavax
Shingles Vaccine
Herpes Zoster Vaccine

An attenuated vaccine used to prevent and/or treat HERPES ZOSTER, a disease caused by HUMAN HERPESVIRUS 3.


Pedunculata Balanus Thoracica Barnacles Sessilia

Genus in the family Balanidae, order Sessilia.


delta Receptor
Receptors, Opioid, delta
Receptors, delta Opioid
delta Opioid Receptor
delta Receptors
Opioid Receptors, delta
Receptors, delta

A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.


The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)


Chlorine Compounds, Inorganic
Chlorine Compounds

Inorganic compounds that contain chlorine as an integral part of the molecule.


Deficiency, Yang
Yangxu
Yang Deficiency
Yang Hsu
Yang Xu

In the YIN-YANG system of philosophy and medicine, a lack of vital energy (called yangxu in Chinese). It manifests itself in various systemic and organic diseases. (The Pinyin Chinese-English Dictionary, 1979)


Medical Equipment, Durable
Equipment, Durable Medical
Equipment, Medical, Durable
Durable Medical Equipment

Devices which are very resistant to wear and may be used over a long period of time. They include items such as wheelchairs, hospital beds, artificial limbs, etc.


A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)


Children, Institutionalized
Institutionalized Child
Child, Institutionalized

A child who is receiving long-term in-patient services or who resides in an institutional setting.


Adrenergic alpha-Receptor Blockaders
alpha-Blockers, Adrenergic
Adrenergic alpha-Blockers
alpha-Adrenergic Receptor Blockaders
Adrenergic alpha-Antagonists
alpha-Adrenergic Blocking Agents
alpha-Adrenergic Antagonists
alpha-Adrenergic Blockers

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.


Tuberculosis, Cutaneous
Scrofuloderma
Tuberculid
Skin Tuberculosis

Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.


Alkylated DNA Repair Protein AlkB Homolog 1

A dioxygenase and alkylation repair homolog that functions by oxidative demethylation in RNA and DNA REPAIR of substrates which contain 3-methylcytosine. It also functions as one of the HISTONE DEMETHYLASES involved in embryonic development and maintaining the pluripotency of EMBRYONIC STEM CELLS.


Pulmonary Surfactant-Associated Protein D

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.


Radionuclide Ventriculography
Ventriculography, Radionuclide

Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.


Cyclic Nucleotide Phosphodiesterases, Type 5

cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.


Cell-surface receptors that specifically bind to WNT PROTEINS and activate the WNT SIGNALING PATHWAY.


An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)


Solomon Seal, False
Maianthemum
Smilacina

A plant genus of the family Asparagaceae. The cluster of flowers at the end of the stalk distinguishes this plant from "true" Solomon's seal (POLYGONATUM), which has flowers that grow along the stem.


Mitral Regurgitation
Mitral Valve Incompetence
Mitral Insufficiency
Mitral Valve Regurgitation
Mitral Valve Insufficiency
Mitral Incompetence

Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.


Thioredoxin-Dependent Peroxide Reductase, Mitochondrial

Mitochondrial Thioredoxin-Dependent Antioxidant Protein SP-22

A THIOREDOXIN-dependent hydroperoxidase that is localized in the mitochondrial matrix. The enzyme plays a crucial role in protecting mitochondrial components from elevated levels of HYDROGEN PEROXIDE.


Proteogenomic Research
Proteogenomic Profiling
Proteogenomics
Proteogenomic Analysis

The systematic study of annotated genomic information to global protein expression in order to determine the relationship between genomic sequences and both expressed proteins and predicted protein sequences.


Th1-Th2 Cytokine Balance
Th1-Th2 Balance

Homeostatic control of the IMMUNE SYSTEM by different CYTOKINES that induce the differentiation of HELPER T-CELLS into TH1 and TH2 CELLS and result in a balance or imbalance (leading to disease) of Th1 and Th2 cells' immune responses.


Intestinal Excretion
Intestinal Elimination

The discharge of substances from the blood supply into the intestinal lumen for excretion by DEFECATION.


BB Wistar Rats
Bio-Breeding Inbred Rats
Rats, BB
Rats, Inbred BB

A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).


Large Bowel Resection
Hemicolectomy
Colectomy

Surgical resection of a portion of or the entire colon.


Basophilic Leukemia, Acute
Leukemia, Basophilic, Acute

A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.


Organ of Zuckerkandl
Organs of Zuckerkandl
Paraaortic Bodies
Para-Aortic Bodies

Small masses of chromaffin cells found near the SYMPATHETIC GANGLIA along the ABDOMINAL AORTA, beginning cranial to the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) or renal arteries and extending to the level of the aortic bifurcation or just beyond. They are also called the organs of Zuckerkandl and sometimes called aortic bodies (not to be confused with AORTIC BODIES in the THORAX). The para-aortic bodies are the dominant source of CATECHOLAMINES in the FETUS and normally regress after BIRTH.


Antisocial Personality Disorder
Psychopathic Personality
Antisocial Personality
Dyssocial Behavior
Personality Disorder, Antisocial
Sociopathic Personality

A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)


ICAM-1
Antigens, CD54
CD54 Antigens
CD54 Antigen
Intercellular Adhesion Molecule-1

A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.


A species of ORTHOPOXVIRUS that is the etiologic agent of COWPOX. It is closely related to but antigenically different from VACCINIA VIRUS.


A substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.


The concept covering the physical and mental conditions of ADOLESCENTS.


A thin lining of closed cavities of the body, consisting of a single layer of squamous epithelial cells (MESOTHELIUM) resting on a thin layer of CONNECTIVE TISSUE, and covered with secreted clear fluid from blood and lymph vessels. Major serous membranes in the body include PERICARDIUM; PERITONEUM; and PLEURA.


N-6 Fatty Acids
Fatty Acids, Omega 6
Fatty Acids, Omega-6
Omega-6 Fatty Acids

FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS.


Philadelphia Chromosome
Ph1 Chromosome
Ph 1 Chromosome

An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).


Well Aging
Ageing Well
Aging Well
Healthy Ageing
Healthy Aging

The development and maintenance of optimal physical, mental, spiritual, and social well-being and function with advancing age.


Occupational Safety and Health Administration (U.S.)

United States Occupational Safety, Health Administration

Occupational Safety, Health Administration, United States

United States Occupational Safety and Health Administration

United States Occupational Safety Administration

United States Occupational Health Administration

An office in the Department of Labor responsible for developing and establishing occupational safety and health standards.


Drug Therapy
Therapy, Drug
Pharmacotherapy
Chemotherapy

The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.


Basic Helix-Loop-Helix Transcription Factors

A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.


Insertion of a solution or compound through the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.


Operative Dentistry
Dentistry, Operative

That phase of clinical dentistry concerned with the restoration of parts of existing teeth that are defective through disease, trauma, or abnormal development, to the state of normal function, health, and esthetics, including preventive, diagnostic, biological, mechanical, and therapeutic techniques, as well as material and instrument science and application. (Jablonski's Dictionary of Dentistry, 2d ed, p237)


Gross Virus
AKR murine leukemia virus
AKR Virus

A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from spontaneous leukemia in AKR strain mice.


Transfer RNA, Tyr
tRNATyr
Tyrosine-Specific tRNA
tRNA(Tyr)
RNA, Transfer, Tyr

A transfer RNA which is specific for carrying tyrosine to sites on the ribosomes in preparation for protein synthesis.


beta-D-Galactosidase
Lactrase
beta-Galactosidase
Lactases
Lactaid
beta-Galactosidase A1
beta-Galactosidases
lac Z Protein
Lactogest
Dairyaid
beta-Galactosidase A2
beta-Galactosidase A3

A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.


HLA-H Antigen
HFE Protein
Hemochromatosis Protein

A membrane protein and MHC class I antigen. It contains an IMMUNOGLOBULIN C1-SET DOMAIN and interacts with BETA 2-MICROGLOBULIN. It may also regulate the interaction of TRANSFERRIN with the TRANSFERRIN RECEPTOR. Mutations in the HFE gene are associated with cases of FAMILIAL HEMOCHROMATOSIS.


Buphenin
Arlidin
Dilatol
Nylidrin
Bufenine
Buphenine
Nylidrin Hydrochloride

A beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.


A non-taxonomic term for unicellular microscopic algae which are found in both freshwater and marine environments. Some authors consider DIATOMS; CYANOBACTERIA; HAPTOPHYTA; and DINOFLAGELLATES as part of microalgae, even though they are not algae.


Hypertriglyceridemia, Familial
Hyper prebeta lipoproteinemia
Familial Type IV Hyperlipoproteinemia
Hyperlipoproteinemia Type IV
Carbohydrate-Inducible Hyperlipemia
Familial Hyperlipoproteinemia Type 4
Hyperlipoproteinemia, Type IV
Hyperprebetalipoproteinemia
Carbohydrate Inducible Hyperlipemia

A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.


A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.


Aneugens
Aneugenic Agents
Aneuploidy-Inducing Agents
Polyploidy-Inducing Agents

Agents which affect CELL DIVISION and the MITOTIC SPINDLE APPARATUS resulting in the loss or gain of whole CHROMOSOMES, thereby inducing an ANEUPLOIDY.


United States Office of Economic Opportunity

A division of the Executive Branch of the United States government concerned with overall planning, promoting, and administering programs relative to the provision of opportunities for economic advancement.


Process of growing viruses in live animals, plants, or cultured cells.


A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.


Investigative Technics
Investigative Techniques

Investigative techniques used in pre-clinical and clinical research, epidemiology, chemistry, immunology, genetics, etc. They do not include techniques specifically applied to DIAGNOSIS; THERAPEUTICS; anesthesia and analgesia; SURGICAL PROCEDURES, OPERATIVE; and DENTISTRY.


Genitourinary Sphincter, Artificial
Urinary Sphincter, Artificial

An artifical implanted device, usually in the form of an inflatable silicone cuff, inserted in or around the bladder neck in the surgical treatment of urinary incontinence caused by sphincter weakness. Often it is placed around the bulbous urethra in adult males. The artificial urinary sphincter is considered an alternative to urinary diversion.


Humeral Head Prosthesis
Artificial Shoulder Joint
Prosthetic Shoulder
Shoulder Prosthesis


Cystic Periventricular Leukomalacia
Leukomalacia, Periventricular
Neonatal Cerebral Leukomalacia
Leucomalacia, Periventricular
Periventricular Leukomalacia
Encephalomalacia, Periventricular

Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)


Complement 1
Complement C1
C1 Complement
Complement Component 1

The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.


T3SS Secretion System
Type III Secretion System
Type 3 Secretion Systems
Bacterial Secretion System, Type III
Type III Secretion Systems
Type 3 Secretion System

Multiprotein transmembrane complexes in GRAM-NEGATIVE BACTERIA involved in either the secretion of effector proteins from the bacterial cytoplasm into host cells, or the secretion and assembly of flagellar components. The major component of the T3SSs is called the injectosome or needle complex.


Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.


tRNA(Val)
tRNAVal
Transfer RNA, Val
Valine-Specific tRNA
RNA, Transfer, Val

A transfer RNA which is specific for carrying valine to sites on the ribosomes in preparation for protein synthesis.


Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)


Endomyocardial Fibroelastosis
Endocardial Fibroelastosis

A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.


Humanitarian Device Exemption
Expanded Access Trials
Compassionate Use
Compassionate Use Trials

Treatment of seriously ill using unapproved techniques, devices, and substances.


AQP5 Protein
Aquaporin 5 Protein
Aquaporin 5
Aquaporin-5

Aquaporin 5 is a water-specific channel protein that is expressed primarily in alveolar, tracheal, and upper bronchial EPITHELIUM. It plays an important role in maintaining water HOMEOSTASIS in the LUNGS and may also regulate release of SALIVA and TEARS in the SALIVARY GLANDS and the LACRIMAL GLAND.


Anthramycin
Anthramycin, (11a alpha)-Isomer
Antramycin

A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.


Fibroblast Growth Factor 7
Keratinocyte Growth Factor
Palifermin

A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.


Dent's Disease
Dent Disease
Dents Disease

X-linked recessive NEPHROLITHIASIS characterized by HYPERCALCIURIA; HYPOPHOSPHATEMIA; NEPHROCALCINOSIS; and PROTEINURIA. It is associated with mutations in the voltage-gated chloride channel, CLC-5 (Dent Disease I). Another group of mutations associated with this disease is in phosphatidylinositol 4,5-bisphosphate-5-phosphatase gene.


A plant genus of the family VALERIANACEAE. It is sometimes called goosefoot cornsalad but should not be confused with true goosefoot (CHENOPODIUM).


General or unspecified injuries involving the UPPER ARM and the FOREARM.


Coma Depasse
Brain Death
Brain Dead
Irreversible Coma

A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)


Hydrophobic and Hydrophilic Interactions

Hydrophilic and Hydrophobic Interactions

The thermodynamic interaction between a substance and WATER.


A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.


A plant genus of the family Anacardiaceae, order Sapindales, subclass Rosidae. It is a source of gallotannin (TANNIC ACID) and of somewhat edible fruit. Do not confuse with TOXICODENDRON which used to be part of this genus.


Grey Platelet Syndrome
Platelet alpha-Granule Deficiency
Gray Platelet Syndrome

A rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time.


Benign Fibrous Mesothelioma
Localized Fibrous Mesothelioma
Solitary Fibrous Tumor, Pleural
Fibrous Mesothelioma
Localized Mesothelioma
Solitary Fibrous Tumor of the Pleura
Solitary Fibrous Mesothelioma
Submesothelial Fibroma

A rare neoplasm, usually benign, derived from mesenchymal fibroblasts located in the submesothelial lining of the PLEURA. It spite of its various synonyms, it has no features of mesothelial cells and is not related to malignant MESOTHELIOMA or asbestos exposure.


A plant genus of the family LILIACEAE. Members contain tuliposides and tulipalins and have been associated with allergic contact dermatitis in florists.


Cerebral Cavernous Malformations 1 Protein

A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS.


Spatial Interpolation
Spatial Dependency
Spatial Autocorrelation
Spatial Analysis
Kriging
Spacial Analysis
Kernel Density Estimation

The degree of interdependence among data arranged on a three-dimensional grid. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


Forkhead Box A3 Protein
Hepatocyte Nuclear Factor 3-gamma
Hepatocyte Nuclear Factor 3gamma
HNF-3gamma Protein

A winged-helix transcription factor that regulates GENE expression in metabolic tissues. It plays a role in HOMEOSTASIS of GLUCOSE and controls expression of GLUT2 PROTEIN.


Venereal Tumors, Transmissible
Tumors, Veterinary Venereal
Tumors, Transmissible Venereal
Veterinary Venereal Tumors
Venereal Tumors, Veterinary
Transmissible Venereal Tumors

Tumors most commonly seen on or near the genitalia. They are venereal, most likely transmitted through transplantation of cells by contact. Metastases have been reported. Spontaneous regression may occur.


Malate Dehydrogenase (NADP)
Malate Dehydrogenase (NADP+)
NADP-Malate Dehydrogenase

A light-activated enzyme that catalyzes the oxidation of (S)-malate to OXALOACETATE. It is involved in PYRUVATE metabolism and CARBON fixation.


Aleutian Mink Disease Virus
Aleutian Disease Virus
Aleutian Mink Disease Parvovirus

A species of PARVOVIRUS that causes a disease in mink, mainly those homozygous for the recessive Aleutian gene which determines a desirable coat color.


Heart-Specific Fatty Acid Binding Protein

A small cytosolic fatty-acid binding protein that forms a lipid-binding beta-barrel structure and is expressed by CARDIOMYOCYTES and at lower levels in brain tissue. It is released into plasma immediately following cardiac injury and may therefore serve as a useful biomarker for the early detection of MYOCARDIAL INFARCTION.


Nutritional Requirements
Nutrition Requirements
Dietary Requirements

The amounts of various substances in food needed by an organism to sustain healthy life.


Surface Variant Glycoproteins, Trypanosoma

Variant Surface Glycoproteins, Trypanosoma

Trypanosoma Variant Surface Coat Glycoproteins

Glycoproteins attached to the surface coat of the trypanosome. Many of these glycoproteins show amino acid sequence diversity expressed as antigenic variations. This continuous development of antigenically distinct variants in the course of infection ensures that some trypanosomes always survive the development of immune response to propagate the infection.


Otic Ganglia
Ciliary Ganglion
Parasympathetic Ganglia
Ganglia, Parasympathetic
Ganglion, Parasympathetic
Submandibular Ganglia
Pterygopalatine Ganglia

Ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen.


Strikes, Employee
Employee Strikes
Strikes

Work-related situations in which the employees as a group refuse to work until certain conditions of employment are granted by the employer.


Cationic Amino Acid Transport Proteins
Cationic Amino Acid Transport Systems
Cationic Amino Acid Transporters
Basic Amino Acid Transport Proteins
Amino Acid Transport Systems, Basic
Basic Amino Acid Transport Systems
Amino Acid Transport Systems, Cationic

Amino acid transporter systems capable of transporting basic amino acids (AMINO ACIDS, BASIC).


Recoverin-Like Calcium-Binding Protein P23k

A neuronal calcium-sensor protein that was initially found in the NEURONS of the HIPPOCAMPUS. It interacts with NEURONAL APOPTOSIS-INHIBITORY PROTEIN.


General Transcription Initiation Complex Proteins

Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.


Diet, Low-Salt
Diet, Sodium-Restricted
Diet, Low-Sodium
Diet, Salt-Free

A diet which contains very little sodium chloride. It is prescribed by some for hypertension and for edematous states. (Dorland, 27th ed)


A plant genus of the family CONVOLVULACEAE. Members contain calystegine and calystegins.


Intestinal Entamoeba histolytica Infection

DYSENTERY caused by intestinal amebic infection, chiefly with ENTAMOEBA HISTOLYTICA. This condition may be associated with amebic infection of the LIVER and other distant sites.


An acute infectious disease caused by RUBULAVIRUS, spread by direct contact, airborne droplet nuclei, fomites contaminated by infectious saliva, and perhaps urine, and usually seen in children under the age of 15, although adults may also be affected. (From Dorland, 28th ed)


Sleep-Related Dystonia
Dystonia, Nocturnal, Paroxysmal
Nocturnal Paroxysmal Dystonia
Hypnogenic Paroxysmal Dystonia

A parasomnia characterized by paroxysmal episodes of choreoathetotic, ballistic, dystonic movements, and semipurposeful activity. The episodes occur during non-rapid eye movement sleep and typically recur several times per night. (Neurology 1992 Jul;42(7 Suppl 6):61-67; Adams et al., Principles of Neurology, 6th ed, p391)


Chondrosarcoma, Clear Cell
Clear Cell Chondrosarcoma

A chondrosarcoma of adolescence to old age of the proximal EPIPHYSES of long bones. It has variably clear cytoplasm of the mostly neoplastic CHONDROCYTES with little intervening matrix.


Nux Vomica
Strychnos nux-vomica
Strychninetree

A plant genus of the genus STRYCHNOS, family LOGANIACEAE that is the source of STRYCHNINE.


Clinical Laboratory Science
Technology, Medical Laboratory
Medical Laboratory Science
Medical Laboratory Technology

The specialty related to the performance of techniques in clinical pathology such as those in hematology, microbiology, and other general clinical laboratory applications.


Abscess, Pulmonary
Abscesses, Pulmonary
Lung Abscess
Pulmonary Abscesses
Pulmonary Abscess

Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.


Immunoglobulins produced in response to VIRAL ANTIGENS.


Piriformis Muscle Syndrome
Piriformis syndrome

A chronic PELVIC PAIN characterized by pain deep in the buttock that may radiate to posterior aspects of the leg. It is caused by the piriformis muscle compressing or irritating the SCIATIC NERVE due to trauma, hypertrophy, inflammation or anatomic variations.


United States Tax Equity and Fiscal Responsibility Act

PL97-248. Title II of the Act specifies "provisions relating to savings in health and income security programs." This includes changes in payment for services, benefits and premiums of Medicare as well as changes in provisions under Medicaid and other specific programs covered by Social Security. Title II includes various revenue measures.


Pigmentary Retinopathy
Tapetoretinal Degeneration
Retinitis Pigmentosa

Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina.


Osteitis, Alveolar
Alveolar Periostitis
Periostitis, Alveolar
Dry Socket
Alveolitis Sicca Dolorosa
Alveolar Osteitis
Alveolalgia

A condition sometimes occurring after tooth extraction, particularly after traumatic extraction, resulting in a dry appearance of the exposed bone in the socket, due to disintegration or loss of the blood clot. It is basically a focal osteomyelitis without suppuration and is accompanied by severe pain (alveolalgia) and foul odor. (Dorland, 28th ed)


Reactive Oxygen Species
Oxygen Radicals
Pro-Oxidants
Active Oxygen
Oxygen Species, Reactive

Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of SIGNAL TRANSDUCTION and GENE EXPRESSION, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.


Cystyl Aminopeptidase
Cystine Arylamidase
Cystidyl Aminopeptidase
Vasopressinase
Cystinaminopeptidase
Cystinyl Aminopeptidase
Cystine Aminopeptidase
Oxytocinase

A zinc-containing sialoglycoprotein that is used to study aminopeptidase activity in the pathogenesis of hypertension. EC 3.4.11.3.


Response Evaluation Criteria in Solid Tumors

An internationally recognized set of published rules used for evaluation of cancer treatment that define when tumors found in cancer patients improve, worsen, or remain stable during treatment. These criteria are based specifically on the response of the tumor(s) to treatment, and not on the overall health status of the patient resulting from treatment.


Flavor Enhancers
Flavor Additives
Flavoring Agents

Substances added to foods and medicine to improve the taste.


Diagnostic Technic, Radioisotope
Radioisotope Diagnostic Techniques
Diagnostic Techniques, Radioisotope
Diagnostic Technics, Radioisotope
Technics, Radioisotope Diagnostic
Radioisotope Diagnostic Technics
Technic, Radioisotope Diagnostic
Techniques, Radioisotope Diagnostic
Technique, Radioisotope Diagnostic
Diagnostic Technique, Radioisotope
Radioisotope Diagnostic Technic
Radioisotope Diagnostic Technique

Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.


Hypersensitivity, Tuberculin-Type
Delayed Hypersensitivity
Hypersensitivity, Type IV
Tuberculin-Type Hypersensitivity
Type IV Hypersensitivity
Hypersensitivity, Delayed

An increased reactivity to specific antigens mediated not by antibodies but by cells.


Intracranial Sinuses
Cranial Sinuses
Cranial Venous Sinuses

Large endothelium-lined venous channels situated between the two layers of DURA MATER, the endosteal and the meningeal layers. They are devoid of valves and are parts of the venous system of dura mater. Major cranial sinuses include a postero-superior group (such as superior sagittal, inferior sagittal, straight, transverse, and occipital) and an antero-inferior group (such as cavernous, petrosal, and basilar plexus).


Genes, erbb2
erbB-2 Genes
Genes, HER2
c-erbB-2 Proto-Oncogenes
Genes, HER-2
c-erbB-2 Genes
Genes, erbB-2
Genes, neu

The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.


Lateral Vestibular Nucleus
Deiter Nucleus
Nucleus Vestibularis Lateralis
Vestibular Nucleus, Lateral
Nucleus Vestibularis Magnocellularis
Deiter's Nucleus
Nucleus of Deiters

Vestibular nucleus lying immediately superior to the inferior vestibular nucleus and composed of large multipolar nerve cells. Its upper end becomes continuous with the superior vestibular nucleus.


Eczema, Atopic
Dermatitis, Atopic
Eczema, Infantile
Neurodermatitis, Atopic
Neurodermatitis, Disseminated

A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.


TATA-Binding Protein-Related Factors
TATA Box Binding Protein-Like Proteins
TBP-Like Protein (TLP)
TBP-Like TLP
TBP-Related Factor
TATA-Binding Protein-Related Factor

A class of proteins related in structure and function to TATA-BOX BINDING PROTEIN that can take the place of TATA-BOX BINDING PROTEIN in the transcription initiation complex. They are found in most multicellular organisms and may be involved in tissue-specific promoter regulation. They bind to DNA and interact with TATA-BINDING PROTEIN ASSOCIATED FACTORS, however they may lack specificity for the TATA-BOX.


Peroxisomal Multifunctional beta-Oxidation Protein

2-Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Dehydrogenase-delta 3, delta 2-Enoyl-CoA Isomerase

A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.


B7 Antigen
B7 Molecules
B7 Antigens
B7 Costimulatory Molecules
Antigen, B7
B-7 Antigen

A family of cell-surface proteins found on ANTIGEN-PRESENTING CELLS. B7 antigens are ligands for specific cell surface receptor subtypes found on T-CELLS. They play an immunomodulatory role by stimulating or inhibiting the T-CELL activation process.


Receptor, EphA1
EphA1 Receptor
EPHA1 Receptor Tyrosine Kinase
Eph Receptor
EPHA1 Protein

The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.


An extracellular selenoprotein that contains most of the SELENIUM in PLASMA. Selenoprotein P functions as an antioxidant and appears to transport selenium from the LIVER to peripheral tissues.


Blood and Lymphatic System Disorders
Hemic and Lymphatic Diseases

Hematologic diseases and diseases of the lymphatic system collectively. Hemic diseases include disorders involving the formed elements (e.g., ERYTHROCYTE AGGREGATION, INTRAVASCULAR) and chemical components (e.g., BLOOD PROTEIN DISORDERS); lymphatic diseases include disorders relating to lymph, lymph nodes, and lymphocytes.


Surgical Time
Time Length of Surgery
Operative Time
Length of Operative Time

The duration of a surgical procedure in hours and minutes.


Health of Military Personnel
Military Health

The physical and mental conditions of MILITARY PERSONNEL, active duty and retired U.S. Military personnel and their dependents.


Genes, Neurofibromatosis 2
Genes, nf2
Neurofibromatosis 2 Genes
nf2 Genes
Genes, nf 2

Tumor suppressor genes located on the long arm of human chromosome 22. Mutation or loss of these genes causes NEUROFIBROMATOSIS 2.


A plant genus of the family RANUNCULACEAE. Members contain isoquinoline alkaloids.


Injections, Intralymphatic
Intralymphatic Injections
Endolymphatic Injections
Injections, Endolymphatic

Injections into the lymph nodes or the lymphatic system.


A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.


Gram-Positive Asporogenous Rods, Regular

Gram Positive Asporogenous Rods, Regular

A group of regular rod-shaped bacteria that stain gram-positive and do not produce endospores.


General or unspecified injuries to the hand.


Vascular Graft Restenosis
Graft Occlusion, Vascular
Vascular Graft Occlusion
Graft Restenosis, Vascular

Obstruction of flow in biological or prosthetic vascular grafts.


Prostacyclins
Prostaglandin I
Prostaglandins I

A class of cyclic prostaglandins that contain the 6,9-epoxy bond. Endogenous members of this family are biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES.


A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.


Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)


Transcription, Reverse
Reverse Transcription

The biosynthesis of DNA carried out on a template of RNA.


Small Cell Carcinoma
Carcinoma, Oat Cell
Carcinoma, Small Cell
Oat Cell Carcinoma

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)


Working Women
Woman, Working
Women, Working

Women who are engaged in gainful activities usually outside the home.


Sodium Bicarbonate
Baking Soda
Sodium Hydrogen Carbonate
Carbonic Acid Monosodium Salt

A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.


Obtaining material for pathological examination and analysis, from bodily fluids. Material retrieved includes CELL-FREE NUCLEIC ACIDS; CELL-DERIVED MICROPARTICLES; EXOSOMES; CIRCULATING NEOPLASM CELLS; and other circulating cells and CELLULAR STRUCTURES.


Cytophagaceae Infections
Flexibacteraceae Infections

Infections with bacteria of the family CYTOPHAGACEAE.


Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.


A sphingolipidosis subtype that is characterized by the histological appearance of granulomatous deposits in tissues. It results from the accumulation of CERAMIDES in various tissues due to an inherited deficiency of ACID CERAMIDASE.


Interrupted Time Series Analysis
ITS Studies
Interrupted Time Series

A study that uses observations at multiple time points before and after an intervention (the "interruption"), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time.


Vascular Endothelial Growth Factor D
FIGF Protein
Vascular Endothelial Growth Factor-D
VEGF-D
c-fos-Induced Growth Factor

A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR C in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.


Bromphenol Blue
Tetrabromophenol Blue
Bromophenol Blue

A dye that has been used as an industrial dye, a laboratory indicator, and a biological stain.


Membranes, Intracellular
Intracellular Membranes

Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.


Huntington Disease Protein
Huntingtin Protein
IT15 Protein

A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.


The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.


Single-Stranded DNA Breaks
Single-Stranded DNA Break
Single-Strand DNA Breaks
DNA Breaks, Single-Stranded
DNA Nicks

Interruptions in one of the strands of the sugar-phosphate backbone of double-stranded DNA.


Sorption Detoxification
Sorption Detoxication
Detoxication, Sorption

Elimination of toxic or biologically active substances from body fluids by interaction with a sorbent medium. The types of media include absorbents, adsorbents, ion-exchange materials, and complexing agents. Detoxification can be extracorporeal (hemodialysis, hemofiltration, hemoperfusion, plasmapheresis), or occur inside the body (enterosorption, peritoneal dialysis).


Complexes, Migrating Motor
Complexes, Migrating Myoelectric
Migrating Motor Complex
Myoelectric Complex, Migrating

A pattern of gastrointestinal muscle contraction and depolarizing myoelectric activity that moves from the stomach to the ILEOCECAL VALVE at regular frequency during the interdigestive period. The complex and its accompanying motor activity periodically cleanse the bowel of interdigestive secretion and debris in preparation for the next meal.


Blushred Rabdosia
Rabdosia japonica
Rabdosia
Isodon
Rabdosia rubescens
Isodon japonica

A plant genus of the family LAMIACEAE used in TRADITIONAL CHINESE MEDICINE.


rho Guanine Nucleotide Dissociation Inhibitor 1

rho GDP Dissociation Inhibitor (GDI) alpha

rho Guanine Nucleotide Dissociation Inhibitor alpha

An abundantly-expressed rho GDP-dissociation inhibitor subtype that regulates a broad variety of RHO GTPASES.


Thiosulfate Cyanide Transsulphurase
Thiosulfate Sulfurtransferase
Thiosulfate Sulphurtransferase
Rhodanese

An enzyme that catalyzes the transfer of the planetary sulfur atom of thiosulfate ion to cyanide ion to form thiocyanate ion. EC 2.8.1.1.


Pleural Aspiration
Chest Aspiration
Thoracocentesis
Thoracentesis
Pleurocentesis

Aspiration of fluid or air from the THORACIC CAVITY. It is coupled sometimes  with the administration of drugs into the PLEURAL CAVITY.


Dermatitis Verrucosa
Chromomycosis
Chromoblastomycosis

Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. The extremity may become swollen and, at its distal portion, covered with various nodular, tumorous, verrucous lesions that resemble cauliflower. In rare instances, the disease may begin on the hand or wrist and involve the entire upper extremity. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p362)


A subcategory of chaperonins found in MITOCHONDRIA; CHLOROPLASTS; and BACTERIA. Group I chaperonins form into a barrel-shaped macromolecular structure that is enclosed by a separate lid-like protein component.


Tumor Necrosis Factor Receptor Superfamily Member X-EDAR

Tumor Necrosis Factor Receptor Superfamily, Member 27

An ectodysplasin receptor subtype that is specific for ECTODYSPLASIN A2. Unlike the EDAR RECEPTOR the Xedar receptor signals through direct association with TNF RECEPTOR-ASSOCIATED FACTORS. The protein name derives from the fact that gene that encodes it resides on the X CHROMOSOME.


The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.


Membrane Transport Modulators
Membrane Transport Protein Modulators

Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS.


Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.


Imperata
Gramineae
Arundo
Alopecurus
Grass
Imperata cylindrica
Poaceae
Grasses

A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.


Chlorine Compounds, Organic
Chlorinated Hydrocarbons
Hydrocarbons, Chlorinated
Organochlorine Compounds

Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE.


Leishmania tropica major
Leishmania major
Leishmania (Leishmania) major
Leishmania leishmania major

A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes cutaneous leishmaniasis (LEISHMANIASIS, CUTANEOUS) of the Old World. Transmission is by Phlebotomus sandflies.


Wurster Blue
Wurster's Reagent
Wurster's Blue
Tetramethylphenylenediamine

Used in the form of the hydrochloride as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES.


Persuasive Communication
Persuasion
Brainwashing

A mode of communication concerned with inducing or urging the adoption of certain beliefs, theories, or lines of action by others.


Norisoprenoids Megastigmanes Nor-Isoprenoids Theaspiranes Irones Vitispiranes Ionones Damascones

Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.


Model, Immunologic
Immunologic Model
Immunological Models
Models, Immunological

Theoretical representations that simulate the behavior or activity of immune system, processes, or phenomena. They include the use of mathematical equations, computers, and other electrical equipment.


Hyperesthesia, Thermal
Hyperesthesia
Oxyesthesia
Hyperesthesia, Tactile
Hyperesthetic Sensations

Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.


Antihyperkalemic Drugs
Antihyperkalemic Agents
Antihyperkalemics

Compounds used to lower excessive POTASSIUM levels in the body.


Early Placental Phase
Pregnancy Trimester, First
Trimester, First
Pregnancy, First Trimester

The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.


Bornean Orangutan
Orangutan, Bornean
Pongo pygmaeus
Pongo pygmaeus pygmaeus

A species of orangutan, family HOMINIDAE, found in the forests on the island of Borneo.


Genome Structural Variants
Genomic Structural Variation
Genomic Structural Variants
Genome Structural Variation

Contiguous large-scale (1000-400,000 basepairs) differences in the genomic DNA between individuals, due to SEQUENCE DELETION; SEQUENCE INSERTION; or SEQUENCE INVERSION.


A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)


Hormonal Antineoplastic Agents
Antineoplastic Agents, Hormonal
Hormonal Antineoplastic Drugs
Antineoplastic Hormonal Drugs
Antineoplastic Hormonal Agents
Hormonal Antineoplastics
Hormonal Agents, Antineoplastic
Antineoplastic Drugs, Hormonal
Antineoplastics, Hormonal

Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)


CYLD Protein
Deubiquitinating Enzyme Cylindromatosis
Deubiquitinating Enzyme CYLD
Cylindromatosis Protein

A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.


Generally refers to the amount of protection available and the kind of loss which would be paid for under an insurance contract with an insurer. (Slee & Slee, Health Care Terms, 2d ed)


fusA Protein
fusA Gene Product
Peptide Elongation Factor G
EF-G
Elongation Factor G

Peptide Elongation Factor G catalyzes the translocation of peptidyl-tRNA from the A to the P site of bacterial ribosomes by a process linked to hydrolysis of GTP to GDP.


A tetraspanin domain-containing uroplakin subtype. It heterodimerizes with UROPLAKIN III to form a component of the asymmetric unit membrane found in urothelial cells.


One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.


Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)


Canine Tracheobronchitis Virus
Herpesvirus 1 (alpha), Canine
Herpesvirus 1, Canid
Canid Herpesvirus 1
Canine Herpesvirus 1

A species of VARICELLOVIRUS virus that causes a disease in newborn puppies.


An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.


Lymphomatosis Virus, Avian
Leukosis Virus, Avian
Avian Leukosis Virus
Rous-Associated Virus

The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.


Wittmaack Ekbom Syndrome
Willis-Ekbom Disease
Restless Leg Syndrome
Restless Legs
Wittmaack-Ekbom Syndrome
Willis Ekbom Syndrome
Willis-Ekbom Syndrome
Restless Legs Syndrome
Willis Ekbom Disease

A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.


Dichelobacter
Dichelobacter nodosus
Bacteroides nodosus

Genus with single species DICHELOBACTER NODOSUS.


A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.


The excretory duct of the testes that carries SPERMATOZOA. It rises from the SCROTUM and joins the SEMINAL VESICLES to form the ejaculatory duct.


Gain of Function Mutation
Activation Mutation

A mutation that results in an increase in a gene's activity or in acquiring a new molecular function or a new pattern of gene expression.


The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. Rosette formation can be used to identify specific populations of these cells.


DNA Polymerase gamma
Mitochondrial DNA Polymerase

A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.


A systemic agricultural fungicide and seed treatment agent.


Cardiac Pacemaker, Artificial
Pacemaker, Artificial

A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).


Antigens, CD124
alpha-subunit, Receptor, Interleukin-4
Receptor, Interleukin-4, alpha Subunit
CD124 Antigen
Interleukin-4 Receptor alpha Chain
CD124 Antigens
Interleukin-4 Receptor alpha Subunit
Interleukin-4 Receptors alpha

A receptor subunit that is a component of the TYPE I INTERLEUKIN-4 RECEPTOR and the TYPE II INTERLEUKIN-4 RECEPTOR. It signals through interaction of its cytoplasmic domain with JANUS KINASES such as JANUS KINASE 1.


Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)


alpha-Chemokines
CXC Chemokines
C-X-C Chemokines
Chemokines, CXC

Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.


Radiographic Image Interpretation, Computer-Assisted

Radiographic Image Interpretation, Computer Assisted

Computer Assisted Radiographic Image Interpretation

Computer-Assisted Radiographic Image Interpretation

Computer systems or networks designed to provide radiographic interpretive information.


Cervical Manipulation
Spinal Manipulation
Manipulation, Spinal
Lumbar Manipulation

Adjustment and manipulation of the vertebral column.