Serylan
GP-121
Phencyclidine Hydrochloride
Phencyclidine Hydrobromide
Sernyl
1-(1-Phenylcyclohexyl)piperidine
Phencyclidine
Angel Dust
CL-395

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.


Voluntary activity without external compulsion.


TNF Receptor-Associated Death Domain Protein

A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.


Receptors, Presynaptic
Presynaptic Receptors
Presynaptic Receptor

Neurotransmitter receptors located on or near presynaptic terminals or varicosities. Presynaptic receptors which bind transmitter molecules released by the terminal itself are termed AUTORECEPTORS.


Individuals who leave school, secondary or college, prior to completion of specified curriculum requirements.


Abnormally low intraocular pressure often related to chronic inflammation (uveitis).


HgCl2
Mercury Perchloride
Mercuric Chloride
Sublimate
Mercury Bichloride
Mercury Dichloride
Corrosive Sublimate
Mercuric Perchloride

Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.


Granuloma Gangraenescens
Granuloma, Lethal Midline
Lethal Midline Granuloma
Polymorphic Reticulosis

A condition that is characterized by multiple sites of lymphoid infiltration, often with an aggressive, necrotizing lesion of the upper airway. The term was used as a synonym for lethal midline granuloma.


Breast-Tumor-Amplified Kinase
Aurora Kinase A
AuroraA Kinase
AURORA2 Protein
STK15 Kinase
Aurora A Kinase
BTAK Protein
Aurora-A Kinase
Aurora Kinases A
AURKA
Aurora A Kinases
Serine-Threonine Protein Kinase 15

An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.


A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in variety of adult tissue such as KIDNEY; LUNG; COLON and OVARY. During embryonic development, ephrin-A4 is expressed in the HIPPOCAMPUS and CEREBRAL CORTEX. It binds preferentially to ephA receptors (EPH FAMILY RECEPTORS) with the exception of the EPHA1 RECEPTOR.


Chromosome 14
Chromosomes, Human, Pair 14

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.


Hygiene, Dental
Dental Hygiene
Oral Hygiene

The practice of personal hygiene of the mouth. It includes the maintenance of oral cleanliness, tissue tone, and general preservation of oral health.


A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)


Prothionamide Protionamide Ektebin Peteha

Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.


Protease La
Endopeptidase La
Lon Protease

A prokaryotic ATP-dependent protease that plays a role in the degradation of many abnormal proteins. It is a tetramer of 87-kDa subunits, each of which contains a proteolytic site and a ATP-binding site.


Water Lily Family
Water-Lilies
Water-Lily Family
Nymphaeaceae

The water lily plant family of aquatic, rhizomatous herbs in the class Magnoliopsida.


Dielectric Spectroscopy
Electrochemical Impedance Spectroscopy
Impedance Spectroscopy

A technique of measuring the dielectric properties of materials, which vary over a range of frequencies depending on the physical properties of the material. The technique involves measuring, over a range of frequencies, ELECTRICAL IMPEDANCE and phase shift of an electric field as it passes through the material.


Food, Organic
Organic Food
Organic Produce

ORGANIC AGRICULTURE products, especially fruits and vegetables.


Osteopathic Hospitals
Hospitals, Osteopathic

Hospitals providing care utilizing the generally accepted medical and surgical methods but with emphasis on the osteopathic system of therapy.


Spasmodic Torticollis
Wryneck
Torticollis, Psychogenic
Cervical Dystonia
Torticollis
Torticollis, Intermittent

A twisted neck symptom that is caused by the spasmodic involuntary muscle contractions in the neck region.


Late Gene Transcription
Early Gene Transcription
Transcription, Genetic
Genetic Transcription

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.


Liver-Derived Lymphocyte Proliferation Inhibiting Protein

A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.


Sialic Acid Binding Ig-like Lectin 3
CD33 Antigen
Glycoprotein gp67
CD33 Antigens
Antigens, CD33
Siglec-3

A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.


Single-Balloon Endoscopy
Single-Balloon Enteroscopy

A balloon-assisted enteroscopy utilizing a flexible endoscope with one overtube balloon control unit.


FRAP (Fluorescence Recovery After Photobleaching)

A method used to study the lateral movement of MEMBRANE PROTEINS and LIPIDS. A small area of a cell membrane is bleached by laser light and the amount of time necessary for unbleached fluorescent marker-tagged proteins to diffuse back into the bleached site is a measurement of the cell membrane's fluidity. The diffusion coefficient of a protein or lipid in the membrane can be calculated from the data. (From Segen, Current Med Talk, 1995).


Postpartum Hemorrhage
Hemorrhage, Postpartum
Immediate Postpartum Hemorrhage
Delayed Postpartum Hemorrhage

Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).


Advanced Glycosylation End Products
Maillard Products
Advanced Maillard Reaction End Products
Maillard Reaction Products
Maillard Reaction End Products
Glycosylation End Products, Advanced
Glycation Endproducts, Advanced
Advanced Glycosylation Endproducts
Glycation End Products, Advanced
Advanced Glycation Endproducts
Advanced Glycation End Products

A heterogeneous group of compounds derived from rearrangements, oxidation, and cross-linking reactions that follow from non-enzymatic glycation of amino groups in proteins. They are also know as Maillard products. Their accumulation in vivo accelerates under hyperglycemic, oxidative, or inflammatory conditions. Heat also accelerates the formation of advanced glycation end products (AGEs) such seen with the browning of food during cooking under or over high heat.


A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.


Receptors, Folate, GPI-Anchored
GPI-Anchored Folate Receptors
Folate Receptors, GPI-Anchored

Cell surface receptors that bind to and transport FOLIC ACID, 5-methyltetrahydrofolate, and a variety of folic acid derivatives. The receptors are essential for normal NEURAL TUBE development and transport folic acid via receptor-mediated endocytosis.


An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.


Olibanum Resin
Olibanum
Frankincense
Frankincense Resin

Resin exudate from certain trees of the genus BOSWELLIA in the BURSERACEAE family.


Mucociliary Clearance
Mucociliary Transport

A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.


Lithonate
Priadel
Lithotabs
Lithium Carbonate
Lithium Bicarbonate
Dilithium Carbonate
CP-15,467-61
Quilinorm-retard
Micalith
NSC-16895
Lithobid
Eskalith
Lithane

A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.


Auditory Stimulation
Acoustic Stimulation
Stimulation, Acoustic
Stimulation, Auditory

Use of sound to elicit a response in the nervous system.


Tetradecanoylphorbol Acetate, 4a alpha-Isomer

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.


A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein

An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.


Small Cell Cancer Of The Lung
Carcinoma, Small Cell Lung
Small Cell Lung Carcinoma
Oat Cell Carcinoma of Lung
Oat Cell Lung Cancer
Small Cell Lung Cancer

A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).


Alternative Complement Activation Pathway

Complement Activation Pathway, Alternative

Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.


A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.


Limited English Proficiency
Limited English Proficient

Limited ability to communicate with or understand English.


Polychloroprene
1,3-Butadiene, 2-chloro-, Homopolymer
Duprene
Chloroprene Polymer
Neoprene

An oil-resistant synthetic rubber made by the polymerization of chloroprene.


Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.


Pentose Shunt
Pentosephosphate Shunt
Hexose Monophosphate Shunt
Pentose Phosphate Pathway
Pentosephosphate Pathway
Pentose Phosphate Shunt
Pentose-Phosphate Pathway

An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.


Seabream
Sparus auratus
Gilthead Bream
Gilthead Seabream
Gilthead Sea Bream
Sparus aurata
Sea Bream

A species of PERCIFORMES commonly used in saline aquaculture.


A species of tapeworm (TAPEWORMS) infecting RATS and MICE but rarely causing disease in humans. Its life cycle involves RODENTS as the definitive host and BEETLES as the intermediate host.


Jaagsiekte Retrovirus
JSRV
Ovine pulmonary adenocarcinoma virus
Jaagsiekte sheep retrovirus

A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).


Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase

Guanosine Cyclic Monophosphate-Dependent Protein Kinases

A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.


Human papillomavirus 6
HPV-6
Human papillomavirus type 6

A type of ALPHAPAPILLOMAVIRUS usually associated with GENITAL WARTS; and LARYNGEAL NEOPLASMS.


Experimental Games
Experimental Game
Games, Experimental
Game, Experimental

Games designed to provide information on hypotheses, policies, procedures, or strategies.


Exons that are created in vivo during LYMPHOCYTE maturation from the V, D, and J gene segments of immunoglobulin superfamily genes (e.g., the IMMUNOGLOBULIN HEAVY CHAIN GENES, or the T-CELL RECEPTOR BETA GENES or T-CELL RECEPTOR GAMMA GENES ) by the VDJ RECOMBINASE system.


Transcription Factor PAX3
Paired Box 3 Protein
PAX3 Transcription Factor
Paired Box Transcription Factor 3

A paired box transcription factor that functions in CELL PROLIFERATION; CELL MIGRATION; and APOPTOSIS. It also is involved in MYOGENESIS and neural development. Mutations in the PAX3 gene are associated with WAARDENBURG SYNDROME TYPE 1.


A pattern recognition receptor that binds DOUBLE-STRANDED RNA. It mediates cellular responses to certain viral pathogens.


A plant genus of the family SOLANACEAE. Members contain steroidal saponins and cause CALCINOSIS in grazing livestock due to high levels of 1 ALPHA,25-DIHYDROXYVITAMIN D3.


Psychiatric Departments, Hospital
Hospital Psychiatric Department
Psychiatric Department, Hospital

Hospital department responsible for the organization and administration of psychiatric services.


Energy-Filtering Transmission Electron Microscopy

Microscopy, Energy-Filtering Transmission Electron

Energy-Filtered Transmission Electron Microscopy

An analytical transmission electron microscopy method using an electron microscope fitted with an energy filtering lens. The method is based on the principle that some of the ELECTRONS passing through the specimen will lose energy when they ionize inner shell electrons of the atoms in the specimen. The amount of energy loss is dependent upon the element. Analysis of the energy loss spectrum (ELECTRON ENERGY-LOSS SPECTROSCOPY) reveals the elemental composition of a specimen. It is used analytically and quantitatively to determine which, how much of, and where specific ELEMENTS are in a sample. For example, it is used for elemental mapping of PHOSPHORUS to trace the strands of NUCLEIC ACIDS in nucleoprotein complexes.


TCF-1 Transcription Factor
Transcription Factor 7
T Cell Transcription Factor 1
T Cell Factor 1

A TCF transcription factor that was originally identified as a DNA-binding protein that interacts with the enhancers of T-CELL RECEPTOR ALPHA GENES. It plays a role in T-LYMPHOCYTE development.


A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES


Infectious Anemia Virus, Equine
Swamp Fever Virus
EIAV
Equine infectious anemia virus

A species of LENTIVIRUS, subgenus equine lentiviruses (LENTIVIRUSES, EQUINE), causing acute and chronic infection in horses. It is transmitted mechanically by biting flies, mosquitoes, and midges, and iatrogenically through unsterilized equipment. Chronic infection often consists of acute episodes with remissions.


Healthcare Workers
Health Personnel
Health Care Providers
Healthcare Providers

Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)


E2F7 Transcription Factor
E2F Transcription Factor 7 Protein
Transcription Factor E2F-7

An E2F transcription factor that represses GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F7 has two separate DNA-binding domains and binds to DNA independently of a dimerization partner.


Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci.  They are used to investigate the contribution of genetic background differences to PHENOTYPE.


Use of computers or computer systems for doing routine clerical work, e.g., billing, records pertaining to the administration of the office, etc.


The historic designation for scrofula (TUBERCULOSIS, LYMPH NODE). The disease is so called from the belief that it could be healed by the touch of a king. This term is used only for historical articles using the name "king's evil", and is to be differentiated from scrofula as lymph node tuberculosis in modern clinical medicine. (From Webster, 3d ed)


Cell Surface Display Techniques
Phage Display Techniques
Cell Surface Display Technology

Techniques utilizing cells that express RECOMBINANT FUSION PROTEINS engineered to translocate through the CELL MEMBRANE and remain attached to the outside of the cell.


Malignant Brenner Tumor
Proliferative Brenner Tumor
Brenner Tumor
Brenner Tumor of Ovary
Ovarian Brenner Tumor
Benign Brenner Tumor


Kanpo Medicine
Kampo
Medicine, Kampo
Kampo Medicine
Kanpo

System of herbal medicine practiced in Japan by both herbalists and practitioners of modern medicine. Kampo originated in China and is based on Chinese herbal medicine (MEDICINE, CHINESE TRADITIONAL).


Joint Capsule Release
Arthroscopic Capsular Release
Capsular Contracture Release
Capsular Release

Surgical procedure to relax the JOINT CAPSULE tissues in a joint that has a reduced range of motion due to CONTRACTURE or TISSUE ADHESIONS or joint deformities.


Works about scientific manuscripts made available prior to PEER REVIEW.


Moderate Sedation
Sedation, Conscious
Sedation, Moderate
Conscious Sedation

A drug-induced depression of consciousness during which patients respond purposefully to verbal commands, either alone or accompanied by light tactile stimulation. No interventions are required to maintain a patent airway. (From: American Society of Anesthesiologists Practice Guidelines)


ATLV
HTLV-I
T-Cell Leukemia Virus I, Human
Leukemia Lymphoma Virus I, Adult T Cell
Adult T-Cell Leukemia-Lymphoma Virus I
Leukemia Virus I, Human T-Cell
Human T-Cell Leukemia Virus I
T Cell Leukemia Virus I, Human
HTLV-1
Human T-lymphotropic virus 1
Human T Cell Leukemia Virus I
Leukemia Virus I, Human T Cell
Adult T Cell Leukemia Lymphoma Virus I

A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).


A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 12 is activated by pro-apoptotic factors that are released during cell stress and by CARD SIGNALING ADAPTOR PROTEINS. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.


Giant Condyloma of Buschke and Löwenstein

Giant Condyloma of Buschke and Lowenstein

Exophytic tumor of the anogenital region associated with HPV infections. It becomes a large cauliflower-like, hyperkeratotic, verrucous mass that is locally destructive with little atypical cells. Histologically, tumor cells are broad rete peg structures that tend to invade deeper than CONDYLOMATA ACUMINATA.


Regulatory RNA Region
Regulatory Sequences, RNA
Regulatory Ribonucleic Acid Region
RNA Regulatory Sequences
Ribonucleic Acid Regulatory Sequences
Regulatory Sequences, Ribonucleic Acid

Sequences within RNA that regulate the processing, stability (RNA STABILITY) or translation (TRANSLATION, GENETIC) of RNA.


Packaging
Product Containers
Packaging, Product
Product Packaging

Form in which product is processed or wrapped and labeled. PRODUCT LABELING is also available.


Immunoglobulins produced in a response to FUNGAL ANTIGENS.


RXR gamma Receptor
Retinoid X Receptor gamma

A nuclear transcription factor. Heterodimerization with PPAR ALPHA is important to metabolism of LIPIDS.


Radiation, Background
Background Radiation
Radiation, Natural
Natural Radiation

Radiation from sources other than the source of interest. It is due to cosmic rays and natural radioactivity in the environment.


Tissue surrounding the apex of a tooth, including the apical portion of the periodontal membrane and alveolar bone.


Congenital Malformations, Nervous System

Nervous System Malformations, Congenital

Malformations, Nervous System, Congenital

Abnormalities, Congenital, Nervous System

Congenital Abnormalities, Nervous System

Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.


Alkylated DNA Repair Protein AlkB Homologs

A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).


S100A6 Protein
S100 Calcium Binding Protein A6
S100-A6 Protein
Calcyclin

An S100 calcium binding protein that contains two EF HAND MOTIFS and plays a role as a calcium sensor and modulator for many cellular processes such as CELL CYCLE progression; CELL MOTILITY and reorganization of the ACTIN CYTOSKELETON. Its expression is induced by growth factors and it is overexpressed in patients with ACUTE MYELOID LEUKEMIA.


Synaptotagmin 1
Synaptotagmin I
p65 Protein (Synaptotagmin I)
Synaptic Vesicle Protein p65

A vesicular transport protein expressed predominately in NEURONS. Synaptotagmin helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.


Autoantibodies directed against newly-formed EPITOPES created as the COMPLEMENT cascade is activated and the proteins involved change their conformations.


Gastroesophageal Junction
Esophagogastric Junction

The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.


Inflation
Economic Inflation
Inflation, Economic

An increase in the volume of money and credit relative to available goods resulting in a substantial and continuing rise in the general price level.


Calgranulin C Protein
CAAF1 Protein
S100A12 Protein
MRP-6 Protein
S100 A12 Protein
ENRAGE Protein
S100A12
EN-RAGE Protein

A member of the S100 PROTEIN FAMILY that regulates INFLAMMATION and the immune response. It recruits LEUKOCYTES, promotes cytokine and chemokine production, and regulates leukocyte adhesion and migration. S100A12 can also function via binding to ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTORS, to stimulate innate immune cells.


Glucosaminephosphate Isomerase (Glutamine Forming)

An enzyme that catalyzes the synthesis of fructose-6-phosphate plus GLUTAMINE from GLUTAMATE plus glucosamine-6-phosphate.


Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.


Insertion Mutation
Sequence Insertion
Mutagenesis, Insertional
Linker-Insertion Mutagenesis
Insertional Mutagenesis
Viral Insertional Mutagenesis
Mutagenesis, Cassette
Gene Insertion
Insertional Activation

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.


HLA Class I Histocompatibility Antigen, A-1 alpha Chain

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*01 allele family.


Secondary Ion Mass Spectrometry Microscopy

Secondary Ion Mass Spectroscopy Microscopy

A mass-spectrometric technique that is used for microscopic chemical analysis. A beam of primary ions with an energy of 5-20 kiloelectronvolts (keV) bombards a small spot on the surface of the sample under ultra-high vacuum conditions. Positive and negative secondary ions sputtered from the surface are analyzed in a mass spectrometer in regards to their mass-to-charge ratio. Digital imaging can be generated from the secondary ion beams and their intensity can be measured. Ionic images can be correlated with images from light or other microscopy providing useful tools in the study of molecular and drug actions.


Methoxyhydroxymandelic Acid
4-Hydroxy-3-Methoxymandelic Acid
Vanillylmandelic Acid
Vanilmandelic Acid

A 3-O-methyl ether of 3,4-dihydroxymandelic acid. It is an end-stage metabolite of CATECHOLAMINES; EPINEPHRINE; and NOREPINEPHRINE.


Nanog Homeobox Protein
Nanog Protein
Nanog Homeobox Transcription Factor

A homeodomain protein and transcription regulator that functions in BLASTOCYST INNER CELL MASS and EMBRYONIC STEM CELL proliferation and CELL SELF RENEWAL. It confers pluripotency on embryonic stem cells and prevents their differentiation towards extraembryonic ENDODERM and trophectoderm (TROPHOBLAST) CELL LINEAGES.


Infection with roundworms of the genus ANISAKIS. Human infection results from the consumption of fish harboring roundworm larvae. The worms may cause acute NAUSEA; VOMITING; or penetrate into the wall of the DIGESTIVE TRACT where they give rise to EOSINOPHILIC GRANULOMA in the STOMACH; INTESTINES; or the OMENTUM.


Heterogeneous-Nuclear Ribonucleoprotein Group M

A group of closely-related 72-74-kDa heterogeneous-nuclear ribonucleoproteins that are involved in RNA SPLICING events.


Diaikron Diabrezide Gliclazide S-1702 Gliklazid Glyade Diamicron Gen-Gliclazide Diaglyk Novo-Gliclazide Glyclazide S-852

An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion.


Infections, Mycoplasma
Mycoplasma Infections
Eperythrozoonosis

Infections with species of the genus MYCOPLASMA.


Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2

Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.


Cerebral Artery, Posterior
Posterior Cerebral Artery

Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.


The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)


Infantile Apparent Life-Threatening Event

Idiopathic Apparent Life-Threatening Event

An event experienced by an infant or a child that is characterized by some combination of apnea, color change, change in muscle tone, choking, and gagging.


Autosomal Dominant Optic Atrophy Kjer Type

Optic Atrophy, Hereditary, Autosomal Dominant

Dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (Hum. Genet. 1998; 102: 79-86). Mutations leading to this condition have been mapped to the OPA1 gene at chromosome 3q28-q29. OPA1 codes for a dynamin-related GTPase that localizes to mitochondria.


Solute Carrier Family 2, Facilitated Glucose Transporter, Member 3 Protein

A major glucose transporter found in NEURONS.


Encephalomyelitides, Venezuelan Equine
Encephalomyelitis, Venezuelan Equine
Encephalitis, Venezuelan Equine
Venezuelan Equine Encephalitis
Equine Encephalitis, Venezuelan
Venezuelan Equine Encephalomyelitides
Equine Encephalomyelitides, Venezuelan

A form of arboviral encephalitis endemic to Central America and the northern latitudes of South America. The causative organism (ENCEPHALITIS VIRUS, VENEZUELAN EQUINE) is transmitted to humans and horses via the bite of several mosquito species. Human viral infection may be asymptomatic or remain restricted to a mild influenza-like illness. Encephalitis, usually not severe, occurs in a small percentage of cases and may rarely feature SEIZURES and COMA. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)


Philosophy, Dental
Dental Philosophy
Dental Philosophies
Philosophies, Dental

The underlying rationale or theoretical basis for the principles of DENTISTRY.


Progesterone 21-Hydroxylase
Cytochrome P450c21
Cytochrome P-450(c-21)
Cytochrome P-450 21-Hydroxylase
Cytochrome P-450 c21
Steroid 21-Monooxygenase
Steroid 21-Hydroxylase
21-Hydroxylase
Steroid-21-Hydroxylase
Cytochrome P-450 CYP21

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).


The protein components of enzyme complexes (HOLOENZYMES). An apoenzyme is the holoenzyme minus any cofactors (ENZYME COFACTORS) or prosthetic groups required for the enzymatic function.


A growth differentiation factor that may play a role in maintaining the undifferentiated state of PLURIPOTENT STEM CELLS by inhibiting the actions of BONE MORPHOGENETIC PROTEINS. Differentiation factor 3 is also considered a nodal signaling ligand that influences the genesis of left-right asymmetry.


A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.


The family Gryllidae consists of the common house cricket, Acheta domesticus, which is used in neurological and physiological studies. Other genera include Gryllotalpa (mole cricket); Gryllus (field cricket); and Oecanthus (tree cricket).


Butyrylthiocholinesterase Benzoylcholinesterase Pseudocholinesterase Butyrylcholinesterase

An aspect of cholinesterase (EC 3.1.1.8).


Any of several South American shrubs of the Erythroxylon genus (and family) that yield COCAINE; the leaves are chewed with alum for CNS stimulation.


Progressive Interstitial Pneumonia of Sheep

Pneumonia, Progressive Interstitial, of Sheep

Chronic respiratory disease caused by the VISNA-MAEDI VIRUS. It was formerly believed to be identical with jaagsiekte (PULMONARY ADENOMATOSIS, OVINE) but is now recognized as a separate entity.


Isoenzyme CPK-MB
Myocardial Creatine Kinase
Creatine Kinase, MB Form
MB Creatine Kinase

An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.


Endothelial Protein C Receptor
EPCR
CD201 Antigen
Antigen, CD201
Antigens, CD201
Protein C Receptor
PROCR

A glycosylated transmembrane receptor for PROTEIN C that is highly expressed by endothelial cells on the surface of large blood vessels in the heart and lungs.  It facilitates protein C activation by the THROMBIN and THROMBOMODULIN complex in blood coagulation.


Intestinal Microbiota Transfer
Fecal Transplantation
Donor Feces Infusion
Fecal Microbiota Transplantation
Fecal Transplant

Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient.


An enzyme of the lyase class that catalyzes the conversion of ATP and oxaloacetate to ADP, phosphoenolpyruvate, and carbon dioxide. The enzyme is found in some bacteria, yeast, and Trypanosoma, and is important for the photosynthetic assimilation of carbon dioxide in some plants. EC 4.1.1.49.


Ectopic Gene Expression
Ectopic Expression

The expression of a gene in an abnormal place,  or at an abnormal  time in an organism. Ectopic Gene  Expression is often induced artificially by genetic techniques.


Receptors, Amino Acid
Receptor, Amino Acid
Receptors, Amino Acids
Amino Acid Receptors

Cell surface proteins that bind amino acids and trigger changes which influence the behavior of cells. Glutamate receptors are the most common receptors for fast excitatory synaptic transmission in the vertebrate central nervous system, and GAMMA-AMINOBUTYRIC ACID and glycine receptors are the most common receptors for fast inhibition.


Oncorhynchus kisutch
Salmon, Silver
Salmon, Coho

An anadromous species of SALMON ranging from the Arctic and Pacific Oceans to Monterey Bay, California and inhabiting ocean and coastal streams. It is familiarly known as the coho or silver salmon. It is relatively small but its light-colored flesh is of good flavor.


Chronic Pain
Pain, Chronic
Widespread Chronic Pain

A form of chronic pain that tends to be non-localized and wide-reaching.


Burkholderia pseudomallei Infection
Melioidosis

A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.


Glioma-Associated Oncogene Family Zinc Finger 3 Protein

A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.


United States National Aeronautics and Space Administration

An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)


Peritoneoscopes Celioscopes Laparoscopes Laparoscope

ENDOSCOPES for examining the abdominal and pelvic organs in the peritoneal cavity.


The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.


Jagged-1 Protein
Jagged1 Protein
Alagille Syndrome Protein
CD339 Antigen
Serrate-1 Protein
Serrate1 Protein
Jagged-1

A serrate-jagged protein that functions as a ligand for NOTCH RECEPTORS. It may regulate CELL DIFFERENTIATION in HEMATOPOIESIS and PHYSIOLOGIC ANGIOGENESIS. Mutations in the Jagged-1 gene are associated with ALAGILLE SYNDROME 1.


Adoxales Sambucales Dipsacales Lonicerales Caprifoliales Viburnales Valerianales

An order of dicotyledonous flowering plants which includes six families. It is best known for its ornamental plants such as LONICERA (honeysuckle), VIBURNUM (arrowwood and guelder rose), and SCABIOSA (scabious, or pincushion flower).


Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.


Tertiary Protein Structure
Protein Structure, Tertiary

The level of protein structure in which combinations of secondary protein structures (ALPHA HELICES; BETA SHEETS; loop regions, and AMINO ACID MOTIFS) pack together to form folded shapes. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure.


A phylum of small sessile aquatic animals living as small tufted colonies. Some appear like hydroids or corals, but their internal structure is more advanced. Most bryozoans are matlike, forming thin encrustations on rocks, shells, or kelp. (Storer & Stebbins, General Zoology, 6th ed, p443)


2-Ethyl-2-Phenylmalonamide Phenylethylmalondiamide Phenylethylmalonamide Ethylphenylmalonamide


Neuropathy, Giant Axonal, Autosomal Recessive

Rare autosomal recessive disorder of INTERMEDIATE FILAMENT PROTEINS. The disease is caused by mutations in the gene that codes gigaxonin protein. The mutations result in disorganization of axonal NEUROFILAMENT PROTEINS, formation of the characteristic giant axons, and progressive neuropathy. The clinical features of the disease include early-onset progressive peripheral motor and sensory neuropathies often associated with central nervous system involvement (INTELLECTUAL DISABILITY, seizures, DYSMETRIA, and CONGENITAL NYSTAGMUS).


4th Ventricle
Fourth Ventricle
Quarto Ventricolo

An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.


Varicose Ulcer
Venous Stasis Ulcers
Venous Hypertension Ulcers
Stasis Ulcer
Venous Ulcer

Skin breakdown or ulceration in the drainage area of a VARICOSE VEIN, usually in the leg.


Octamer Transcription Factor OTF-1
OTF-1 Transcription Factor
Nuclear Factor III
Octamer Transcription Factor 1
Transcription Factor OTF-1
Octamer Transcription Factor-1
NFIII Transcription Factor
Oct-1 Transcription Factor
Transcription Factor Oct-1

A ubiquitously expressed octamer transcription factor that regulates GENETIC TRANSCRIPTION of SMALL NUCLEAR RNA; IMMUNOGLOBULIN GENES; and HISTONE H2B genes.


Health Surveys, Dental
Health Survey, Dental
Survey, Dental Health
Surveys, Dental Health
Dental Health Survey
Dental Health Surveys

A systematic collection of factual data pertaining to dental or oral health and disease in a human population within a given geographic area.


Artificial T-Cell Receptors
Chimeric Immunoreceptors
Chimeric T-Cell Receptors
Chimeric Antigen Receptors
Receptors, Chimeric Antigen

Synthetic cellular receptors that reprogram T-LYMPHOCYTES to selectively bind antigens.


F-Box Domain Protein
F-Box Proteins
F-Box Protein Family

A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.


Interferon-gamma Release Assays
Interferon-gamma Release Tests

The assay of INTERFERON-GAMMA released from lymphocytes after their exposure to a specific test antigen, to check for IMMUNOLOGIC MEMORY resulting from a previous exposure to the antigen. The amount of interferon-gamma released is usually assayed by an ENZYME-LINKED IMMUNOSORBENT ASSAY.


Solute Carrier Family 2, Facilitated Glucose Transporter, Member 2 Protein

A glucose transport facilitator that is expressed primarily in PANCREATIC BETA CELLS; LIVER; and KIDNEYS. It may function as a GLUCOSE sensor to regulate INSULIN release and glucose HOMEOSTASIS.


Complement Receptor 2
C3d Receptors
Herpesvirus 4 Receptors, Human
Receptors, Epstein-Barr Virus
Receptors, C3d
Complement Receptors 2
Receptors, Complement 3d
CD21 Antigens
Antigens, CD21
CR2 Receptors
Receptors, CR2
CD21 Antigen
Complement 3d Receptors
Complement 3d Receptor
Epstein-Barr Virus Receptors
CD 21 Antigens
Epstein-Barr Virus Receptor

Molecular sites on or in B-lymphocytes, follicular dendritic cells, lymphoid cells, and epithelial cells that recognize and combine with COMPLEMENT C3D. Human complement receptor 2 (CR2) serves as a receptor for both C3dg and the gp350/220 glycoprotein of HERPESVIRUS 4, HUMAN, and binds the monoclonal antibody OKB7, which blocks binding of both ligands to the receptor.


Leucine (Branched-Chain Amino Acid) Dehydrogenase

An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. Leucine dehydrogenase catalyzes the reversible oxidative deamination of L-LEUCINE, to 4-methyl-2-oxopentanoate (2-ketoisocaproate) and AMMONIA, with the corresponding reduction of the cofactor NAD+.


Observation Units
Clinical Decision Units
Clinical Observation Units

A hospital unit that serves as a dedicated observation area for emergency room patients when a decision to admit or not is unclear. Also known as clinical decision units or short-stay observation units.


Behavior, Dangerous
Hazardous Behavior
Dangerous Behavior
Dangerousness

Actions which have a high risk of being harmful or injurious to oneself or others.


Instinct
Innate Behavior
Fixed Action Pattern

Stereotyped patterns of response, characteristic of a given species, that have been phylogenetically adapted to a specific type of situation.


AIH
Artificial Insemination, Husband
Insemination, Homologous
Insemination, Artificial, Husband
Insemination, Artificial, Homologous
Homologous Insemination

Human artificial insemination in which the husband's semen is used.


Right Bundle Branch of His
Left Bundle Branch of His
Atrioventricular Bundle
Anterior Fascicle
Bundle of His
Posterior Fascicle
Kent-His Bundle

The left bundle branch of His splits into anterior and posterior hemifascicles.


beta-AR Kinase
beta-Adrenergic Receptor Kinases
beta-Adrenergic Receptor Kinase

G-protein-coupled receptor kinases that mediate agonist-dependent PHOSPHORYLATION and desensitization of BETA-ADRENERGIC RECEPTORS.


A picolinic acid derivative that is used as a herbicide.


Hartmanns Solution
Lactated Ringers Solution
Ringer's, Lactated
Hartmann's Solution
Ringers Lactate
Ringer's Lactate
Lactated Ringer's Solution

A crystalloid solution that contains SODIUM CHLORIDE; SODIUM LACTATE; POTASSIUM CHLORIDE; and CALCIUM CHLORIDE. It is used for FLUID THERAPY.


Abnormalities, Stomatognathic System
Stomatognathic System Abnormalities

Congenital structural abnormalities of the mouth and jaws, including the dentition.


This amino acid is formed during the urea cycle from citrulline, aspartate and ATP. This reaction is catalyzed by argininosuccinic acid synthetase.


Information Systems, Clinical Pharmacy
Clinical Pharmacy Information Systems

Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of clinical pharmacy services.


Positive-Pressure Ventilation
Positive End-Expiratory Pressure
Positive-Pressure Respiration

A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.


Analgesics
Anodynes
Analgesic Agents
Analgesic Drugs
Antinociceptive Agents

Compounds that show activity in animal models of human PAIN such as tail flick and hot plate assays.


Hashimoto's Disease
Chronic Lymphocytic Thyroiditis
Hashimoto Thyroiditis
Hashimoto's Struma
Hashimoto's Syndrome
Hashimoto Struma
Hashimoto Disease

Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.


A family of extremely venomous snakes which include coral snakes, cobras and sea snakes. They are widely distributed, occurring in the Southern United States, South America, Africa, Southern Asia, Australia, and the Pacific Islands. Like viperids (VIPERIDAE), they have fangs in the front part of the upper jaw which discharge venom that is neurotoxic.


HLA Class II Histocompatibility Antigen, DQ alpha Chains

Transmembrane proteins that form the alpha subunits of the HLA-DQ antigens.


Employment Application
Resume, Job
Job Application

Process of applying for employment. It includes written application for employment or personal appearance.


Expiration, Respiratory
Exhalation
Exhaling


Heparin Secretory Transforming Protein-2

A fibroblast growth factor that was initially identified based on its sequence similarity to FIBROBLAST GROWTH FACTOR 4. It is found in MYOBLASTS and plays an important role in MUSCLE DEVELOPMENT.


DNA Helicases
DNA Helicase II
DNA Helicase III
DNA Helicase A
DNA Unwinding Proteins
ATP-Dependent DNA Helicases
DNA Helicase E

Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.


Bacterial Spore
Spore, Bacterial
Spores, Bacterial
Bacterial Spores

Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.


A species of baboon in the family CERCOPITHECIDAE with a somewhat different social structure than PAPIO HAMADRYAS. They inhabit several areas in Africa south of the Sahara.


Residencies, Non-Medical
Internships, Nonmedical
Residency, Nonmedical
Non-Medical Internship
Nonmedical Internship
Nonmedical Internships
Nonmedical Residency
Residencies, Nonmedical
Residency, Non-Medical
Nonmedical Residencies
Internship, Nonmedical
Non-Medical Internships
Internships, Non-Medical
Internship, Non-Medical

Advanced programs of training to meet certain professional requirements in fields other than medicine or dentistry, e.g., pharmacology, nutrition, nursing, etc.


Amino Acid Chloromethyl Ketones
Peptide Chloromethyl Ketones

Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.


Sterilization, Involuntary
Compulsory Sterilization
Forced Sterilization
Involuntary Sterilization

Interference of a person's reproductive ability without the consent of the person or guardian.


Acrosomal proteinase
Akrosin
M beta-Acrosin
Acrosin

A trypsin-like enzyme of spermatozoa which is not inhibited by alpha 1 antitrypsin.


Serpin Family G Member 1
C1-Inhibitor Protein
Complement C1-Inhibitor Protein
C1 Esterase Inhibitor
Serpin G1
Plasma Protease C1 Inhibitor
Complement C1 Inhibitor Protein
SERPING1
C1-INH Protein

An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II.


Salmonella enterica serovar enteritidis
Salmonella enteritidis

A serotype of Salmonella enterica which is an etiologic agent of gastroenteritis in man and other animals.


V28 Receptor
Receptor, V28
V28 Receptors
Fractalkine Receptor
CX(3)C Receptor
CX3C Chemokine Receptor 1
CX(3)CR1
CX3C Receptor

Receptor for CHEMOKINE CX3CL1 expressed by lymphocytes, neurons, and GLIAL CELLS. Its interaction with CX3CL1 mediates CELL ADHESION and CELL MIGRATION. It also functions as a co-receptor with the CD4 ANTIGEN for HIV-1 in vitro.


The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)


Glyceraldehyde-3-Phosphate Dehydrogenase (NAD+) (Phosphorylating)

An NAD-dependent glyceraldehyde-3-phosphate dehydrogenase found in the cytosol of eucaryotes. It catalyses the dehydrogenation and phosphorylation of GLYCERALDEHYDE 3-PHOSPHATE to 3-phospho-D-glyceroyl phosphate, which is an important step in the GLYCOLYSIS pathway.


Drug Laws
Food, Drug and Cosmetic Act
Drug Legislation
Narcotic Laws
Legislation, Drug

Laws concerned with manufacturing, dispensing, and marketing of drugs.


Steroid Isomerases
3-Ketosteroid Isomerases
3-Oxosteroid Isomerases

Enzymes that catalyze the transposition of double bond(s) in a steroid molecule. EC 5.3.3.


Illegal Immigrants
Undocumented Immigrants
Illegal Aliens
Undocumented Workers
Undocumented Aliens
Unauthorized Immigrants

Foreign nationals residing in a country without legal immigration status, or in violation of the immigration laws of that country.


An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K+. It also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine, and other 3-substituted amino acids. (From Enzyme Nomenclature, 1992) EC 4.1.99.1.


A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships.


Provocation Tests, Nasal
Nasal Provocation Tests

Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.


Herpes Zoster Ophthalmicus
Herpes Zoster, Ocular

Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve.


Sulfachloropyridazine
Sulphachlorpyridazine
Sulfachlorpyridazine
Sulfachlorpyridazine, Monosodium Salt

A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.


Pulmonary Sarcoidosis
Sarcoidosis, Pulmonary

Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)


A range of methods used to reduce pain and anxiety during dental procedures.


Potassium Channels, Sodium-Activated
Potassium Channels, Sodium-Dependent
K+ Channels, Sodium-Activated
Sodium-Activated Potassium Channel
Sodium-Activated Potassium Channels

Potassium channels whose activation is dependent on intracellular sodium concentrations.


Behavior Risk Factor Surveillance System

Telephone surveys are conducted to monitor prevalence of the major behavioral risks among adults associated with premature MORBIDITY and MORTALITY. The data collected is in regard to actual behaviors, rather than on attitudes or knowledge. The Centers for Disease Control and Prevention (CDC) established the Behavioral Risk Factor Surveillance System (BRFSS) in 1984.


Regulation of Gene Expression, Bacterial

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.


Gastric Volvulus
Stomach Volvulus
Volvulus, Stomach

Twisting of the STOMACH that may result in gastric ISCHEMIA and GASTRIC OUTLET OBSTRUCTION. It is often associated with DIAPHRAGMATIC HERNIA.


Muscle Rigidity
Catatonic Rigidity
Gegenhalten
Extensor Rigidity
Extrapyramidal Rigidity
Nuchal Rigidity
Rigidity, Muscular
Cogwheel Rigidity

Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)


Subatomic particles that are either protons or neutrons.


6-Methylmercaptopurine Riboside
Methylthioinosine
6-Methylthiopurine Riboside

6-(Methylthio)-9-beta-D-ribofuranosylpurine. An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.


Interphalangeal Joint of Foot
Interphalangeal Joint of Toe
Toe Joint

The articulation between the head of one phalanx and the base of the one distal to it, in each toe.


Murine pneumonia virus
Pneumonia Virus of Mice

A species of the genus PNEUMOVIRUS causing pneumonia in mice.


General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.


Roux-en-Y Loop
Roux-en-Y Anastomosis
Roux-en-Y Diversion
Anastomosis, Roux-en-Y

A Y-shaped surgical anastomosis of any part of the digestive system which includes the small intestine as the eventual drainage site.


Compounds that include 1,2-diphenylethane in their structure.


The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.


Parapodium
Orthoses
Orthotic Devices
Orthosis

Apparatus used to support, align, or augment the functioning of parts of the body.


Maxillary Sinus
Antrum of Highmore
Maxillary Antrum

The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.


Phencyclidine Receptors
Receptors, Phencyclidine
PCP Receptor
PCP Receptors
Phencylidine Receptor
Receptors, PCP

Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.


A plant genus of the family Anthocerotaceae, order Anthocerotales, class Anthocerotopsida.


Vasostomy
Vasovasostomy
Vasectomy Reversal

Surgical anastomosis or fistulization of the spermatic ducts to restore fertility in a previously vasectomized male.


Mouth Dryness
Asialia
Hyposalivation
Xerostomia


A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.


Rapid Eye Movement Sleep Behavior Disorder

Behavior Disorder, Rapid Eye Movement Sleep

A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)


A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).


Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's.


Pestivirus Infections
Infections, Pestivirus

Infections with viruses of the genus PESTIVIRUS, family FLAVIVIRIDAE.


Murine polyomavirus
Polyoma Viruses
Polyoma Virus
Polyomavirus
Bovine polyomavirus
Hamster polyomavirus

A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.


Society, Medical
Medical Society
Societies, Medical
Medical Societies

Societies whose membership is limited to physicians.


Cerebral Malaria
Malaria, Cerebral
Malaria Meningitis

A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)


Protein Structure Elements
Protein Structural Elements
Protein Structural Units

Distinguishing three-dimensional structures characteristically formed by homologous protein sequences.


Trichomonas Vaginitis
Trichomoniasis, Human

Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.


Acute Anterior Wall Myocardial Infarction

MYOCARDIAL INFARCTION in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction.


Stem Cells, Hematopoietic
Progenitor Cells, Hematopoietic
Hematopoietic Stem Cells
Colony-Forming Units, Hematopoietic
Hematopoietic Progenitor Cells

Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood.


Fetoplacental Function Tests
Placental Function Tests

Methods used for the assessment of placental function.


Any of various large waterfowl in the order Anseriformes, especially those of the genera Anser (gray geese) and Branta (black geese). They are larger than ducks but smaller than swans, prefer FRESH WATER, and occur primarily in the northern hemisphere.


The nursing specialty concerning care of children from birth to adolescence. It includes the clinical and psychological aspects of nursing care.


para-Hydroxybenzoate Hydroxylase
p-Hydroxybenzoate Hydroxylase
4-Hydroxybenzoate-3-Monooxygenase

A flavoprotein that catalyzes the synthesis of protocatechuic acid from 4-hydroxybenzoate in the presence of molecular oxygen. EC 1.14.13.2.


Visual Field Exam
Visual Field Tests
Automated Perimetry Exam
Tangent Screen Exam
Perimetry
Campimetry

Method of measuring and mapping the scope of vision, from central to peripheral of each eye.


Very toxic and complex pyrone derivatives from the fungus Calcarisporium arbuscula. They bind to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation. They are used as biochemical tools.


Toxicity Tests, Acute
Acute Toxicity Tests

Experiments designed to determine the potential toxic effects of one-time, short-term exposure to a chemical or chemicals.


MC4 Receptor
Melanocortin-4 Receptor
Receptor, Melanocortin, Type 4
Melanocortin 4 Receptor
Receptor, Melanocortin-4
Melanocortin Receptor 4

A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH and ADRENOCORTICOTROPIC HORMONE.


Cyclic AMP-Dependent Protein Kinase Type 1

Protein Kinase Type I, Cyclic AMP-Dependent

Cyclic AMP-Dependent Protein Kinase Type I

A cyclic AMP-dependent protein kinase subtype primarily found in the CYTOPLASM. They are tetrameric proteins that contain two catalytic subunits and two type I-specific regulatory subunits.


Compounds consisting of two phenyl groups joined by a urea. Derivatives may be used as ANTIPARASITIC AGENTS.


Acute Inferior Myocardial Infarction
Diaphragmatic Myocardial Infarction
Inferior Myocardial Infarction
Myocardial Infarction, Inferior Wall
Inferior Wall Myocardial Infarction

MYOCARDIAL INFARCTION in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery.


An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.


Right Ventricle
Cardiac Ventricle
Heart Ventricles
Heart Ventricle
Cardiac Ventricles
Left Ventricle

The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.


Fructose 1,6-Bisphosphate Aldolase, Class II

An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.


Petrous Pyramid
Petrous Bone
Petrous Apex

The dense rock-like part of temporal bone that contains the INNER EAR. Petrous bone is located at the base of the skull. Sometimes it is combined with the MASTOID PROCESS and called petromastoid part of temporal bone.


Hyperthermia of Anesthesia
Malignant Hyperpyrexia
Malignant Hyperthermia
Anesthesia Related Hyperthermia
Hyperthermia, Malignant
Hyperpyrexia, Malignant

Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.


Lobus Nervosus
Infundibular Process
Posterior Lobe of Pituitary
Neurohypophysis
Neural Lobe
Pars Nervosa of Pituitary
Pituitary Gland, Posterior

Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.


Penicillin V Acylase
Cephalosporin Acylase
Benzylpenicillin Acylase
Penicillin G Acylase
Penicillin Amidohydrolase
Penicillin Amidase
Penicillin Acylase

An enzyme catalyzing the hydrolysis of penicillin to penicin and a carboxylic acid anion. EC 3.5.1.11.


A plant genus of the family ASTERACEAE. Members contain scandenolide (a sesquiterpene lactone) and germacranolides.


Bovine Encephalitis Virus
Bovine Herpesvirus 5
Herpesvirus 5, Bovine

A species of VARICELLOVIRUS that causes a fatal MENINGOENCEPHALITIS in calves.


Protein Degradation End Products
End Products of Protein Degradation

Degraded protein components that are found within TISSUES, bodily fluids, and cells under certain pathological conditions. They are largely formed through chemical reactions which occur during non-physiological conditions such as ISCHEMIA; HYPERGLYCEMIA; and PHYSIOLOGICAL STRESS.


Customary standards that govern behavior in groups, cultures, or societies. They reflect what a group deems acceptable in a social context in terms of appropriate and inappropriate values, beliefs, attitudes, and behaviors.


Infections, Borrelia
Borrelia Infections

Infections with bacteria of the genus BORRELIA.


Spinocerebellar Ataxia Proteins
Ataxin Proteins
Ataxins

A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.


Refusal to Treat, Conscientious
Conscientious Refusal to Treat

Refusal of health professionals to provide medical services on the basis of moral or religious beliefs.


Spirochaetales Infections
Infections, Spirochete
Infections, Spirochaetales
Spirochete Infections

Infections with bacteria of the order SPIROCHAETALES.


WW Domain-Containing Oxidoreductase
WWOX Protein

A short chain oxidoreductase that contains two N-terminal WW DOMAINS and functions as a tumor suppressor and in APOPTOSIS. It is also required for bone development.


Chemical Depression
Depression, Chemical

The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.


A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.


A family of bullet-shaped viruses of the order MONONEGAVIRALES, infecting vertebrates, arthropods, protozoa, and plants. Genera include VESICULOVIRUS; LYSSAVIRUS; EPHEMEROVIRUS; NOVIRHABDOVIRUS; Cytorhabdovirus; and Nucleorhabdovirus.


Death Penalty
Capital Punishment
Electrocution, Judicial
Lethal Injection
Hanging, Judicial
Gas Chamber Execution

The carrying-out of death sentence by means of hanging by the neck.


kappa Opioid Receptor
kappa Receptors
Receptors, Opioid, kappa
Receptors, kappa
Opioid Receptors, kappa
kappa Receptor
Receptors, kappa Opioid

A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.


Dihydroxyacetone Phosphate
Dihydroxyacetone 3-Phosphate

An important intermediate in lipid biosynthesis and in glycolysis.


Fatty Alcohol:NAD+ Oxidoreductase Deficiency

Congenital Icthyosis Mental Retardation Spasticity Syndrome

Ichthyosis, Spastic Neurologic Disorder, and Oligophrenia

Fatty Aldehyde Dehydrogenase Deficiency Disease

An autosomal recessive neurocutaneous disorder characterized by severe ichthyosis MENTAL RETARDATION; SPASTIC PARAPLEGIA; and congenital ICHTHYOSIS. It is caused by mutation of gene encoding microsomal fatty ALDEHYDE DEHYDROGENASE leading to defect in fatty alcohol metabolism.


Phytochrome B Protein
Phytochrome B
PhyB Phytochrome

A plant photo regulatory protein that exists in two forms that are reversibly interconvertible by LIGHT. In response to light it moves to the CELL NUCLEUS and regulates transcription of target genes. Phytochrome B plays an important role in shade avoidance and mediates plant de-etiolation in red light.


Edema, Pulmonary
Wet Lung
Pulmonary Edema
Edemas, Pulmonary
Pulmonary Edemas

Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.


Negative Reinforcement
Psychological Reinforcement
Reinforcement, Psychology
Reinforcement (Psychology)
Positive Reinforcement

The strengthening of a conditioned response.


An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.


Immunoproliferative Small Intestinal Disease

A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA.


The making of a continuous circular tear in the anterior capsule during cataract surgery in order to allow expression or phacoemulsification of the nucleus of the lens. (Dorland, 28th ed)


Education, Dental, Continuing
Continuing Dental Education
Dental Education, Continuing

Educational programs designed to inform dentists of recent advances in their fields.


Clostridium botulinum type D
Clostridium botulinum D

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type D which is neurotoxic to ANIMALS, especially CATTLE, but not humans.


Osteopathic Manipulative Medicine
Medicine, Osteopathic
Osteopathic Medicine

A medical discipline that is based on the philosophy that all body systems are interrelated and dependent upon one another for good health. This philosophy, developed in 1874 by Dr. Andrew Taylor Still, recognizes the concept of "wellness" and the importance of treating illness within the context of the whole body. Special attention is placed on the MUSCULOSKELETAL SYSTEM.


Secretory Granules
Secretory Vesicles
Zymogen Granules
Dense Core Vesicles
Condensing Vacuoles

Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.


Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.


Physiology, Comparative
Comparative Physiology

The biological science concerned with similarities or differences in the life-supporting functions and processes of different species.


National Institute of General Medical Sciences (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.


Bone Sialoprotein II
Bone Sialoprotein
Integrin-Binding Sialoprotein
Bone Sialoprotein 2

A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.


Benzo(a)pyrene Hydroxylase
Benzo(a)pyrene Monooxygenase
Benzopyrene Hydroxylase
Benzopyrene-3-Monooxygenase

A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.


Carcinoma, Bronchiolar
Carcinoma, Bronchiolo-Alveolar
Adenocarcinoma, Bronchiolo-Alveolar
Carcinoma, Bronchioloalveolar
Alveolar Cell Carcinoma
Carcinoma, Alveolar
Adenocarcinoma, Alveolar

A carcinoma derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)


Ammoniated Ruthenium Oxychloride
Ruthenium Red

An inorganic dye used in microscopy for differential staining and as a diagnostic reagent. In research this compound is used to study changes in cytoplasmic concentrations of calcium. Ruthenium red inhibits calcium transport through membrane channels.


A broadly distributed protein that binds directly to ACTIVINS. It functions as an activin antagonist, inhibits FOLLICLE STIMULATING HORMONE secretion, regulates CELL DIFFERENTIATION, and plays an important role in embryogenesis. Follistatin is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin family (INHIBINS). Follistatin also binds and neutralizes many members of the TRANSFORMING GROWTH FACTOR BETA family.


Peptide Initiation Factor EIF-1
EIF-1
Eukaryotic Peptide Initiation Factor-1
Eukaryotic Initiation Factor-1

A eukaryotic initiation factor that binds to 40S ribosomal subunits. Although initially considered a "non-essential" factor for eukaryotic transcription initiation, eukaryotic initiation factor-1 is now thought to play an important role in localizing RIBOSOMES at the initiation codon of MRNA.


Abdominal Fat
Abdominal Adipose Tissue
Fat, Abdominal
Adipose Tissue, Abdominal

Fatty tissue in the region of the ABDOMEN. It includes the ABDOMINAL SUBCUTANEOUS FAT and the INTRA-ABDOMINAL FAT.


Hydrobiology
Aquatic Biology
Aquatic Ecology

The study of aquatic life inhabiting bodies of water, including growth, morphology, physiology, genetics, distribution, and interactions with other organisms and the environment. It includes MARINE HYDROBIOLOGY.


Stress, Endoplasmic Reticulum
Endoplasmic Reticulum Stress

Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.


A formamide in which the amino hydrogens are replaced by methyl groups.


Syphilis, Congenital
Congenital Syphilis
Hutchinson's Teeth

Syphilis acquired in utero and manifested by any of several characteristic tooth (Hutchinson's teeth) or bone malformations and by active mucocutaneous syphilis at birth or shortly thereafter. Ocular and neurologic changes may also occur.


An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.


Trihydroxy derivatives of eicosanoic acids. They are primarily derived from arachidonic acid, however eicosapentaenoic acid derivatives also exist. Many of them are naturally occurring mediators of immune regulation.


Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.


Invasive Mole
Chorioadenoma
Hydatidiform Mole, Invasive

A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.


Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.


The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.


Norwalk-like Viruses
Small Round-Structured Viruses
Norovirus

A genus in the family CALICIVIRIDAE, associated with epidemic GASTROENTERITIS in humans. The type species, NORWALK VIRUS, contains multiple strains.


Solitary Mastocytoma of Skin
Skin Mastocytoma
Mastocytoma, Skin

A variant of cutaneous mastocytosis which occurs as a single lesion usually in infants. It is found mostly in the wrist and trunk and there is no atypical cytomorphology.


RNA, usually prepared by transcription from cloned DNA, which complements a specific mRNA or DNA and is generally used for studies of virus genes, distribution of specific RNA in tissues and cells, integration of viral DNA into genomes, transcription, etc. Whereas DNA PROBES are preferred for use at a more macroscopic level for detection of the presence of DNA/RNA from specific species or subspecies, RNA probes are preferred for genetic studies. Conventional labels for the RNA probe include radioisotope labels 32P and 125I and the chemical label biotin. RNA probes may be further divided by category into plus-sense RNA probes, minus-sense RNA probes, and antisense RNA probes.


Mother-Fetus Relations
Mother-Fetus Relationship
Maternal-Fetal Relations

The bond or lack thereof between a pregnant woman and her FETUS.


Laurence-Moon Syndrome
Laurence-Moon-Biedl Syndrome

An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)


M5 Muscarinic Receptor
Receptor, Muscarinic M5
Receptors, Muscarinic M5
Muscarinic Receptors M5
Muscarinic Receptor M5

A specific subtype of muscarinic receptor found in a variety of locations including the SALIVARY GLANDS and the SUBSTANTIA NIGRA and VENTRAL TEGMENTAL AREA of the BRAIN.


Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter

A vesicular glutamate transporter protein that is predominately expressed in the DIENCEPHALON and lower brainstem regions of the CENTRAL NERVOUS SYSTEM.


Nitrite Reductase (Reduced Nicotinamide Adenine Dinucleotide (Phosphate))

An enzyme found primarily in BACTERIA and FUNGI that catalyzes the oxidation of ammonium hydroxide to nitrite. It is an iron-sulfur HEME; FLAVOPROTEIN containing siroheme and can utilize both NAD and NADP as cofactors. This enzyme was formerly classified as EC 1.6.6.4.


5-Enolpyruvyl Shikimic Acid 3-Phosphate Synthetase

An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and shikimate-3-phosphate. The shikimate pathway is present in BACTERIA and PLANTS but not in MAMMALS.


Spermatogenesis-Blocking Agents
Spermatogenesis Blocking Agents

Chemical substances which inhibit the process of spermatozoa formation at either the first stage, in which spermatogonia develop into spermatocytes and then into spermatids, or the second stage, in which spermatids transform into spermatozoa.


A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.


PAX7 Transcription Factor
Transcription Factor PAX7
Paired Box Protein Pax-7
Paired Box Transcription Factor 7

A paired box transcription factor that is involved in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM and SKELETAL MUSCLE.


Gelsolin Protein
Gelsolin
Serum Actin Inhibitory Protein

A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.


Oxidoreductases Acting on CH-NH2 Group Donors

Enzymes catalyzing the dehydrogenation of or oxidation of compounds containing primary amines.


Limited Scleroderma
Limited Systemic Scleroderma
Scleroderma, Limited

The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.


Dendrimer
Dendrons
Dendritic Polymers
Dendritic Compounds
Dendrimers

Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.


Orotidine 5' Phosphate Decarboxylase
Orotidine 5 Phosphate Decarboxylase
OMP Decarboxylase
Orotidine-5'-Phosphate Decarboxylase
Orotidylate Decarboxylase
Orotidine Phosphate Carboxy-Lyase
Orotidine-5-Phosphate Decarboxylase

Orotidine-5'-phosphate carboxy-lyase. Catalyzes the decarboxylation of orotidylic acid to yield uridylic acid in the final step of the pyrimidine nucleotide biosynthesis pathway. EC 4.1.1.23.


Ventilator-Induced Lung Injury
Lung Injury, Ventilator-Induced

Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.


Casein Kinase Iepsilon
Casein Kinase 1 epsilon

A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM.


Blood Platelet Transfusion
Platelet Transfusion

The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.


Nuclear Localization Signal Peptide
NLS Peptide
Nuclear Localization Signals
Nuclear Localization Signal

Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.


United States Office of National Drug Control Policy

United States. Office of National Drug Control Policy

A component of the Executive Office of the President established by the Anti-Drug Abuse Act of 1988. The Office establishes policies, priorities, and objectives for national DRUG AND NARCOTIC CONTROL. The goals of the program are to reduce illicit drug use, manufacturing, and trafficking, drug-related crime and violence, and drug-related health consequences.


HLA Class I Histocompatibility Antigen, B-52 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*52 allele family.


Infections, RNA Virus
RNA Virus Infections


Chinese Water Chestnut
Water Chestnut, Chinese
Eleocharis
Chestnut, Water


Plasmids controlling the synthesis of hemolysin by bacteria.


Polycose
Glucose Polymer
Glucan (BO)
Polyglucoses
Glucans

Polysaccharides composed of repeating glucose units. They can consist of branched or unbranched chains in any linkages.


Omega-3 Fatty Acids
n-3 PUFA
Fatty Acids, Omega-3
n3 Oils
n3 Fatty Acid
Omega 3 Fatty Acids
n3 Polyunsaturated Fatty Acid
n-3 Fatty Acids
n-3 Polyunsaturated Fatty Acid
n-3 Oils
n3 PUFA

A group of unsaturated fatty acids occurring mainly in fish oils, with three double bonds at particular positions in the hydrocarbon chain.


Medical Fee
Medical Fees
Fees, Medical
Fee, Medical

Amounts charged to the patient as payer for medical services.


Arachidonic Acid Lipoxygenase
Arachidonate Lipoxygenases

Enzymes catalyzing the oxidation of arachidonic acid to hydroperoxyarachidonates. These products are then rapidly converted by a peroxidase to hydroxyeicosatetraenoic acids. The positional specificity of the enzyme reaction varies from tissue to tissue. The final lipoxygenase pathway leads to the leukotrienes. EC 1.13.11.- .


Used as an indicator in titrating iron and for the colorimetric determination of chromium and the detection of cadmium, mercury, magnesium, aldehydes, and emetine.


Analysis, Matched-Pair
Matched-Pair Analysis
Paired Comparisons

A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).


Murine Acquired Immunodeficiency Syndrome

Murine Acquired Immuno-Deficiency Syndrome

Murine Acquired Immune Deficiency Syndrome

Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas.


Pregnancy Outcome
Pregnancy Outcomes
Outcomes, Pregnancy
Outcome, Pregnancy

Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.


Reading Disability, Acquired
Dyslexia, Acquired
Alexia, Acquired
Acquired Global Dyslexia
Word Blindness, Acquired
Acquired Spelling Dyslexia

A receptive visual aphasia characterized by the loss of a previously possessed ability to comprehend the meaning or significance of handwritten words, despite intact vision. This condition may be associated with posterior cerebral artery infarction (INFARCTION, POSTERIOR CEREBRAL ARTERY) and other BRAIN DISEASES.


Degloving Wounds
Skin Avulsion Injuries
Degloving Injuries
Skin Avulsion

Avulsions of the superficial tissues of SKIN and SUBCUTANEOUS TISSUE from the underlying FASCIA.


Pyroglutamyl-Peptidase I
Pyrrolidonecarboxylate Peptidase
Pyroglutamyl-Peptide Hydrolase
Pyrrolidonyl Peptidase
5-Oxoprolyl-Peptidase
Pyroglutamate Aminopeptidase

An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided the next residue is not proline. It is inhibited by thiol-blocking reagents and occurs in mammalian tissues, microorganisms, and plants. (From Enzyme Nomenclature, 1992) EC 3.4.19.3.


Xanthene dye used as a bacterial and biological stain. Synonyms: Pyronin; Pyronine G; Pyronine Y. Use also for Pyronine B. which is diethyl-rather than dimethylamino-.


Hydroxystilbene Derivatives
Stilbestrols
Hydroxyl-Stilbenes

Stilbene derivatives the contain one or more hydroxyl groups attached to the benzene ring structures.


Pleurodynia, Epidemic
Bornholm Disease
Myalgia, Epidemic

An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.


15-Methylprostaglandin E2
Arbacet
Arbaprostil
U-42842

A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors.


Amaurosis Fugax
Blindness, Monocular, Transient
Monocular Blindness, Transient

Transient complete or partial monocular blindness due to retinal ischemia. This may be caused by emboli from the CAROTID ARTERY (usually in association with CAROTID STENOSIS) and other locations that enter the central RETINAL ARTERY. (From Adams et al., Principles of Neurology, 6th ed, p245)


Cytotoxic T-Lymphocyte-Associated Antigen 4

An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.


Folate Receptor beta
Folic Acid Receptor beta
Folate Receptor, Placental
Folate Receptor 2
Placental Folate-Binding Protein
Folate Receptor, Fetal

A subtype of GPI-anchored folate receptors that is expressed in PLACENTA and hematopoietic cells.


Candidiasis, Cutaneous
Moniliasis, Cutaneous

Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)


Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.


Familial Nonhemolytic Unconjugated Hyperbilirubinemia

A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.


A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.


Gas Chromatography
Chromatography, Gas-Liquid
Chromatography, Gas

Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.


Chronic Delta Hepatitis
Chronic Hepatitis D
Delta Hepatitis, Chronic
Hepatitis D, Chronic

INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS in conjunction with HEPATITIS B VIRUS and lasting six months or more.


Iron-Deficiency Anemias
Anemias, Iron-Deficiency
Iron-Deficiency Anemia
Anemia, Iron-Deficiency

Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.


Floor of Mouth
Sublingual Region
Mouth Floor

The area of the mouth beneath the TONGUE.


The puncture of a vein to draw blood for diagnostic analysis or to inject a solution.


Health Facilities, Proprietary
Proprietary Health Facilities
Privately Sponsored Programs

Health care institutions operated by private groups or corporations for a profit.


Cytochromes of the c type that are involved in the transfer of electrons from CYTOCHROME B6F COMPLEX and PHOTOSYSTEM I.


Thermonuclease
Micrococcal Nuclease
TNase
Thermostable Nuclease
Staphylococcal Nuclease

An enzyme that catalyzes the endonucleolytic cleavage to 3'-phosphomononucleotide and 3'-phospholigonucleotide end-products. It can cause hydrolysis of double- or single-stranded DNA or RNA. (From Enzyme Nomenclature, 1992) EC 3.1.31.1.


Statistics, Nonparametric
Statistics, Non-Parametric
Nonparametric Statistics
Rank-Sum Tests
Spearman Rank Correlation Coefficient
Mann-Whitney U Test
Wilcox Test
Non-Parametric Statistics
Kruskal-Wallis H Statistic
Kolmogorov-Smirnov Test
Wilcoxon Rank Test

A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)


Laminin-5 Receptor (alpha6beta4 Integrin)

This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.


A type II keratin that is found associated with the KERATIN-14 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-5 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.


Plant Proteins, Dietary
Dietary Plant Proteins
Vegetable Proteins

Proteins which are present in or isolated from vegetables or vegetable products used as food. The concept is distinguished from PLANT PROTEINS which refers to non-dietary proteins from plants.


Tuberculosis, Cardiovascular
Cardiovascular Tuberculosis

Pathological conditions of the CARDIOVASCULAR SYSTEM caused by infection of MYCOBACTERIUM TUBERCULOSIS. Tuberculosis involvement may include the HEART; the BLOOD VESSELS; or the PERICARDIUM.


TRP53 Protein
Tumor Suppressor Protein p53
TP53 Protein
p53 Tumor Suppressor Protein
Oncoprotein p53
Cellular Tumor Antigen p53
pp53 Phosphoprotein
p53 Antigen

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.


Hospital Obstetrics and Gynecology Department

Obstetrics, Gynecology Department, Hospital

Obstetrics and Gynecology Department, Hospital

Hospital department responsible for the administration and management of services provided for obstetric and gynecologic patients.


Transient Receptor Potential Cation Channel Subfamily C, Member 6

A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.


Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)


Enhancer Elements
Enhancer Elements, Genetic
Enhancer Sequences

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.


Regulatory-Associated Protein of mTOR
RPTOR Protein
RAPTOR Protein

An adaptor protein component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 that forms stoichiometric complexes with TOR KINASES, which it negatively regulates. It functions as a positive regulator of RIBOSOMAL PROTEIN S6 KINASES.


Habits and practices conducive to getting the right amount and quality of sleep, and include  responding to environmental factors that may influence one's sleep.


Nephropathy, Balkan
Balkan Endemic Nephropathy
Balkan Nephropathy
Endemic Nephropathy, Balkan
Danubian Endemic Familial Nephropathy

A form of chronic interstitial nephritis that is endemic to limited areas of BULGARIA, the former YUGOSLAVIA, and ROMANIA. It is characterized by a progressive shrinking of the KIDNEYS that is often associated with uroepithelial tumors.


Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.


Receptor, Insulin-Like Growth Factor Type 1

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.


Carcinogens
Tumor Promoters
Oncogens
Tumor Initiators

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.


The type species in the genus NOROVIRUS, first isolated in 1968 from the stools of school children in Norwalk, Ohio, who were suffering from GASTROENTERITIS. The virions are non-enveloped spherical particles containing a single protein. Multiple strains are named after the places where outbreaks have occurred.


The act or fact of grasping the meaning, nature, or importance of; understanding. (American Heritage Dictionary, 4th ed) Includes understanding by a patient or research subject of information disclosed orally or in writing.


Anthelmintic used in grazing animals for fasciola and cestode infestations.


Hyperbaric Oxygenation
Hyperbaric Oxygen Therapy
Oxygenation, Hyperbaric

The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.


Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.


Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha2-Agonists
Adrenergic alpha-2 Agonists
Adrenergic alpha-2 Receptor Agonist

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.


Bends
Decompression Sickness
Caisson Disease

A condition occurring as a result of exposure to a rapid fall in ambient pressure. Gases, nitrogen in particular, come out of solution and form bubbles in body fluid and blood. These gas bubbles accumulate in joint spaces and the peripheral circulation impairing tissue oxygenation causing disorientation, severe pain, and potentially death.


Muc1 Mucin
CA 15-3 Antigen
Polymorphic Epithelial Mucin
Antigen CA-15-3
Episialin
Mucin-1
Antigens, CD227
CD227 Antigen
CA-15-3 Antigen
CA 15.3 Antigen
Epithelial Membrane Antigen
Epithelial Mucin, Polymorphic

Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.


Paralysis, Pseudobulbar
Pseudobulbar Syndrome
Pseudobulbar Palsy
Pseudobulbar Paresis
Dysarthria, Pseudobulbar
Pseudobulbar Mutism
Pseudobulbar Paralysis
Spastic Bulbar Palsy

A syndrome characterized by DYSARTHRIA, dysphagia, dysphonia, impairment of voluntary movements of tongue and facial muscles, and emotional lability. This condition is caused by diseases that affect the motor fibers that travel from the cerebral cortex to the lower BRAIN STEM (i.e., corticobulbar tracts); including MULTIPLE SCLEROSIS; MOTOR NEURON DISEASE; and CEREBROVASCULAR DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p489)