Short-Wave Therapy
Therapy, Shortwave
Therapy, Short-Wave
Shortwave Therapy
Short Wave Therapy

The use of focused short radio waves to produce local hyperthermia in an injured person or diseased body area.


Biological Rhythms
Cyclicity
Biorhythms
Rhythmicity
Bioperiodicity
Periodicity

The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).


Catechol Oxidase
Diphenol Oxidase
Polyphenoloxidase
Polyphenol Oxidase
Diphenol Oxidases

An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.


Tuberous Sclerosis Complex 1 Protein
Hamartin

An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.


Psychotherapy, Short-Term
Psychotherapy, Brief
Short-Term Psychotherapy
Brief Psychotherapy
Solution-Focused Brief Therapy

Psychotherapy that is brief and focuses on solutions, rather than on problems


Pernicious Vomiting of Pregnancy
Hyperemesis Gravidarum

Intractable VOMITING that develops in early PREGNANCY and persists. This can lead to DEHYDRATION and WEIGHT LOSS.


Ciliary Neurotrophic Factor Receptor alpha Subunit

Ciliary Neurotrophic Factor Receptor alpha Chain

A ciliary neurotrophic factor receptor subunit. It is anchored to the cell surface via GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and has specificity for binding to CILIARY NEUROTROPHIC FACTOR. It lacks signal transducing domains which are found on the other two subunits of the receptor.


GABA-B Receptor Antagonist
GABA-B Antagonists
GABA-B Receptor Antagonists

Drugs that bind to but do not activate GABA-B RECEPTORS thereby blocking the actions of endogenous or exogenous GABA-B RECEPTOR AGONISTS.


A plant genus of the family ASTERACEAE that is similar to CONYZA. Members contain SESQUITERPENES.


Medically Unexplained Symptoms
Somatic Symptoms

Persistent health symptoms which remain unexplained after a complete medical evaluation. A cluster of symptoms that consistently appear together but without a known cause are referred to as a MEDICALLY UNEXPLAINED SYNDROME (MUS).


zeta-Chain Associated Protein Kinase (ZAP-70)

A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.


Cordemcura 5-Amino-(3,4'-bipyridine)-6(1H)-one Amrinone Win-40680 Wincoram Amrinon Inocor

A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.


Tumor Necrosis Factor Ligand Superfamily Member 7

A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.


Melanoma Antigen Recognized by T-Cells 1

A melanosome-specific protein that plays a role in the expression, stability, trafficking, and processing of GP100 MELANOMA ANTIGEN, which is critical to the formation of Stage II MELANOSOMES. The protein is used as an antigen marker for MELANOMA cells.


Electrospray Ionization Mass Spectrometry

Spectrometry, Mass, Electrospray Ionization

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.


Lingual Frenum
Lingual Frenulum
Frenum, Lingual

MUCOUS MEMBRANE extending from floor of mouth to the under-surface of the tongue.


alpha-2 Antiplasmin
alpha 2-Plasmin Inhibitor
Serpin F2
alpha(2)-Plasmin Inhibitor
alpha-2-Antiplasmin

A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.


Vision Disparity
Parallax, Ocular
Fixation Disparity
Binocular Disparity
Visual Disparity
Ocular Disparity
Retinal Disparity

The difference between two images on the retina when looking at a visual stimulus. This occurs since the two retinas do not have the same view of the stimulus because of the location of our eyes. Thus the left eye does not get exactly the same view as the right eye.


A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)


Education, Competency-Based
Competency-Based Education

Educational programs designed to ensure that students attain prespecified levels of competence in a given field or training activity. Emphasis is on achievement or specified objectives.


Anxiety due to fantasized injuries to or loss of the genitals.


Physical Maltreatment
Physical Violence
Physical Abuse

Violence inflicted on an individual through physical contact.


Cardiovascular Abnormalities
Abnormalities, Cardiovascular

Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.


Diamond. A crystalline form of carbon that occurs as hard, colorless or tinted isomeric crystals. It is used as a precious stone, for cutting glass, and as bearings for delicate mechanisms. (From Grant & Hackh's Chemical Dictionary, 5th ed)


Lanosterol 14 alpha-Demethylase Inhibitors

Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.


Thromboangitis Obliterans
Thromboangiitis Obliterans
Buerger Disease
Buerger's Disease

A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.


Nematode Infections
Infections, Nematode

Infections by nematodes, general or unspecified.


Sixth Cranial Nerve
Nervus Abducens
Abducens Nerve
Nerve VI
Cranial Nerve VI
Abducent Nerve

The 6th cranial nerve which originates in the ABDUCENS NUCLEUS of the PONS and sends motor fibers to the lateral rectus muscles of the EYE. Damage to the nerve or its nucleus disrupts horizontal eye movement control.


Circulatory and Respiratory Physiological Phenomenon

Circulatory and Respiratory Physiological Phenomena

Functional processes and properties characteristic of the BLOOD; CARDIOVASCULAR SYSTEM; and RESPIRATORY SYSTEM.


An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.


General or unspecified injuries to the posterior part of the trunk. It includes injuries to the muscles of the back.


Strains of Enterobacteriaceae that are resistant to CARBAPENEMS, primarily due to the acquisition of carbapenemase (BETA-LACTAMASE) genes.


Financing, Public
Government Financing
Hill-Burton Act
Federal Aid
Grants and Subsidies, Government
Subsidies, Government
Financing, Government

Federal, state, or local government organized methods of financial assistance.


American House Dust Mite
Dermatophagoides farinae
House Dust Mite, American

Species of American house dust mite, in the family PYROGLYPHIDAE.


Mitogen-Activated Protein Kinase 7 Isoform 1

Mitogen-Activated Protein Kinase 7 Isoform 2

A 110-kDa extracellular signal-regulated MAP kinase that is activated in response to cellular stress and by GROWTH FACTOR RECEPTORS-mediated pathways.


Vaccinia Virus H1-Related Protein Tyrosine Phosphatase

A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES.


The outer margins of the thorax containing SKIN, deep FASCIA; THORACIC VERTEBRAE; RIBS; STERNUM; and MUSCLES.


Glutamate Synthase (NADH)
NADH-GOGAT
NADH-Dependent Glutamate Synthase
L-Glutamate Synthetase
NADH-Glutamate Synthase

A FLAVOPROTEIN enzyme for AMMONIA assimilation in BACTERIA, microorganisms and PLANTS. It catalyzes the oxidation of 2 molecules of L-GLUTAMATE to generate L-GLUTAMINE and 2-oxoglutarate in the presence of NAD+.


Micromanufacturing Microtechnology Microfabrication Micromachining

Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.


Receptor, TIE-1
TIE1 Tyrosine Kinase
TIE-1 Receptor Tyrosine Kinase

A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.


A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics.


Health Care Rationing
Healthcare Rationing
Rationing, Health Care

Planning for the equitable allocation, apportionment, or distribution of available health resources.


PFAN Protein
Desmoglein 1
Dsg1 Antigen
Desmoglein I
Desmosomal Glycoprotein 1
Pemphigus Foliaceus Antigen

A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS FOLIACEUS.


Programmed Cell Death 1 Ligand 2 Protein

A costimulatory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 RECEPTOR. It is closely-related to CD274 antigen; however, its expression is restricted to DENDRITIC CELLS and activated MACROPHAGES.


Automotive safety devices consisting of a bag designed to inflate upon collision and prevent passengers from pitching forward. (American Heritage Dictionary, 1982)


Conjugated Linoleic Acid (CLA)
Linoleic Acids, Conjugated

A collective term for a group of around nine geometric and positional isomers of LINOLEIC ACID in which the trans/cis double bonds are conjugated, where double bonds alternate with single bonds.


CT10 Regulator of Kinase Oncogene Protein

A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.


Trochlear Nerve
Nerve IV
Fourth Cranial Nerve
Cranial Nerve IV

The 4th cranial nerve. The trochlear nerve carries the motor innervation of the superior oblique muscles of the eye.


tRNA(Asn)
Asparagine-Specific tRNA
tRNAAsn
RNA, Transfer, Asn
Transfer RNA, Asn

A transfer RNA which is specific for carrying asparagine to sites on the ribosomes in preparation for protein synthesis.


Function of the human eye that is used in dim illumination (scotopic intensities) or at nighttime. Scotopic vision is performed by RETINAL ROD PHOTORECEPTORS with high sensitivity to light and peak absorption wavelength at 507 nm near the blue end of the spectrum.


Williams-Campbell Syndrome
Chondromalacia of Trachea and Bronchi
Tracheobronchomalacia

A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the TRACHEA and the BRONCHI. This results in a floppy non-rigid airway making patency difficult to maintain.


CCCTC-Binding Factor
CTCF Protein
DNA-Binding Protein CTCF

A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.


Insurance, Nursing Services
Nursing Services Insurance

Insurance providing benefits for the costs of care provided by nurses, especially nurse practitioners and nurse clinicians.


Degos's Malignant Atrophic Papulosis
Erythrokeratoderma en cocardes
Degos Disease
Kohlmeier-Degos Disease
Papulosis, Malignant Atrophic
Malignant Atrophic Papulosis
Degos Syndrome

Variously described as a vasculopathy, endovasculitis, or occlusive arteriopathy, this condition occurs in a benign cutaneous form and a lethal multiorgan systemic variant. It is characterized by a narrowing and occlusion of the lumen of small to medium-sized blood vessels, leading to ischemia and infarction in the involved organ systems. The etiology and pathophysiology are unknown.


Sperm Capacitation
Capacitation of Spermatozoa

The structural and functional changes by which SPERMATOZOA become capable of oocyte FERTILIZATION. It normally requires exposing the sperm to the female genital tract for a period of time to bring about increased SPERM MOTILITY and the ACROSOME REACTION before fertilization in the FALLOPIAN TUBES can take place.


Serine Proteases
Serine Proteinase
Serine Proteinases
Serine Protein Hydrolases
Serine Protease

Peptide hydrolases that contain at the active site a SERINE residue involved in catalysis.


A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)


Public Health Students
Students, Public Health

Individuals enrolled in a school of PUBLIC HEALTH or a formal educational program in public health.


Cytochrome P-450 CYP2D6 Inducers
CYP2D6 Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP2D6.


Phenols substituted with one or more chlorine atoms in any position.


Occlusal Adjustment
Occlusal Equilibration

Selective grinding of occlusal surfaces of the teeth in an effort to eliminate premature contacts and occlusal interferences; to establish optimal masticatory effectiveness, stable occlusal relationships, direction of main occlusal forces, and efficient multidirectional patterns, to improve functional relations and to induce physiologic stimulation of the masticatory system; to eliminate occlusal trauma; to eliminate abnormal muscle tension; to aid in the stabilization of orthodontic results; to treat periodontal and temporomandibular joint problems; and in restorative procedures. (From Jablonski, Dictionary of Dentistry, 1992)


Octanols
Alcohols, Octyl
Hydroxyoctanes
Heptylcarbinols
Octylic Alcohols

Isomeric forms and derivatives of octanol (C8H17OH).


GABA-B Receptor Agonist
GABA-B Receptor Agonists
GABA-B Agonists

Endogenous compounds and drugs that bind to and activate GABA-B RECEPTORS.


Influenza A Virus, H7N3 Subtype
H7N3 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 7 and neuraminidase 3. It was first detected in turkeys in Britain in 1963 and there have been several outbreaks on poultry farms since that time. A couple cases of human infections have been reported.


Hospital Financial Management
Managements, Hospital Financial
Financial Managements, Hospital
Management, Hospital Financial
Financial Management, Hospital
Hospital Financial Managements

The obtaining and management of funds for hospital needs and responsibility for fiscal affairs.


A carboxypeptidase that is specific for proteins that contain two ALANINE residues on their C-terminal. Enzymes in this class play an important role in bacterial CELL WALL biosynthesis.


Cofactors, Enzyme
Coenzymes
Enzyme Cofactors

Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.


Antagonists, Endothelin B Receptor
Endothelin B Receptor Blockers
Blockers, Endothelin B Receptor
Endothelin B Receptor Antagonists

Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN B RECEPTORS.


Equivalencies, Clinical
Therapeutic Equivalency
Equivalencies, Therapeutic
Equivalency, Clinical
Clinical Equivalency
Generic Equivalency
Therapeutic Equivalencies
Clinical Equivalencies
Bioequivalence
Equivalency, Therapeutic

The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.


PTH2 Receptor
Receptor, Parathyroid Hormone, Type 2
PTH-2 Receptor
Parathyroid Hormone Receptor 2

A parathyroid hormone receptor subtype found in the BRAIN and the PANCREAS. It is a G-protein-coupled receptor with a ligand specificity that varies between homologs from different species.


Eburicol 14alpha-Demethylase
Obtusifoliol 14alpha-Demethylase
Lanosterol 14 alpha-Demethylase
Sterol 14-Demethylases
Sterol 14-Demethylase
Eburicol 14 alpha-Demethylase
CYP51 Cytochrome P-450
Cytochrome P-450 CYP51
Sterol 14-alpha-Demethylase

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.


Immunoglobulins, Fc
Immunoglobulin Fc Fragment
Immunoglobulins, Fc Fragment
Immunoglobulin Fc Fragments
Fc Fragments
Fc Immunoglobulins
Ig Fc Fragments

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.


X-Ray Micro-Computed Tomography
X-Ray Micro-CT Scans
Microcomputed Tomography
X-Ray Microcomputed Tomography
MicroCT
X-Ray Microtomography
X-Ray Micro-CT
Xray Micro-CT
Xray MicroCT
X-Ray Micro-CAT Scans
X-ray MicroCT

X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.


Malherbe Calcifying Epithelioma
Pilomatricoma
Benign Pilomatricoma
Epithelioma Calcificans Of Malherbe
Benign Pilomatrixoma
Calcifying Epithelioma of Malherbe
Pilomatrixoma

A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401)


May Apple
Mayapple
Podophyllum peltatum
Mandrake, American

A plant of the genus PODOPHYLLUM, family BERBERIDACEAE (sometimes classified as Podophyllaceae) which is the source of PODOPHYLLIN and of PODOPHYLLOTOXIN that inhibits DNA TOPOISOMERASES, TYPE II. It is different from the European mandrake, MANDRAGORA.


A family of plant viruses containing the largest single-stranded RNA genomes. Infections typically involve yellowing and necrosis, particularly affecting the phloem.


Nucleotide-binding Domain Leucine-rich Repeat Proteins

Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.


Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.


Prolyl-Hydroxylase Inhibitors
Proline Hydroxylase Inhibitors
Proline Dioxygenase Inhibitors

Compounds that inhibit the action of HYDROXYLASES that act on PROLINE to form HYDROXYPROLINE.


Neighborhood Health Centers
Community Health Centers
Satellite Centers

Facilities which administer the delivery of health care services to people living in a community or neighborhood.


A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.


Fractures, Compression
Compression Fractures

Crumbling or smashing of cancellous BONE by forces acting parallel to the long axis of bone. It is applied particularly to vertebral body fractures (SPINAL FRACTURES). (Blauvelt and Nelson, A Manual of Orthopedic Terminology, 1994, p4)


Aspartic Oxidase
D-Aspartate Oxidase
D-aspartic Oxidase

An FAD-dependent peroxisomal flavoenzyme, this catalyzes the oxidative deamination of D-ASPARTATE to OXALOACETATE and AMMONIA using oxygen as electron acceptor.


SI Units
International System of Units
Systeme International d'Unites

A system of physical units in which the fundamental quantities are length, time, mass, electric current, temperature, luminous intensity, and amount of substance, and the corresponding units are the meter, second, kilogram, ampere, kelvin, candela, and mole. The system has been given official status and recommended for universal use by the General Conference on Weights and Measures.


von Willebrand Disease, Type I
von Willebrand Disease, Type 1
Type 1 von Willebrand Disease
Type I von Willebrand Disease

A subtype of von Willebrand disease that results from a partial deficiency of VON WILLEBRAND FACTOR.


Patient Refusal of Treatment
Refusal of Treatment
Patient Elopement
Treatment Refusal
Anesthesia Refusal

Patient or surrogate refusal of specific type of anesthesia or any anesthesia.


L-Threonyl-L-Lysyl-L-Prolyl-L-Arginine L-Thr-L-Lys-L-Pro-L-Arg Taftsin Tuftsin

N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.


Rubbing Alcohol
Isopropyl Alcohol
Isopropanol
2-Propanol

An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.


The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.


Radiographic visualization or recording of a vein after the injection of contrast medium.


Organizational Decision Making
Decision Making, Organizational

The process by which decisions are made in an institution or other organization.


Temporomandibular Joint Dysfunction Syndrome

Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint

A symptom complex consisting of pain, muscle tenderness, clicking in the joint, and limitation or alteration of mandibular movement. The symptoms are subjective and manifested primarily in the masticatory muscles rather than the temporomandibular joint itself. Etiologic factors are uncertain but include occlusal dysharmony and psychophysiologic factors.


Parietal Cells, Gastric
Oxyntic Cells
Gastric Parietal Cells

Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.


An enzyme that catalyzes the condensation of two molecules of geranylgeranyl diphosphate to give prephytoene diphosphate. The prephytoene diphosphate molecule is a precursor for CAROTENOIDS and other tetraterpenes.


Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.


CCL11 Chemokine
Chemokine (C-C Motif) Ligand 11
Eotaxin-1
Chemokine CCL11
Small Chemokine (C-C Motif) Ligand 11

A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.


Geminivirus Geminiviridae Mastrevirus Topocuvirus Curtovirus

A genus of the family GEMINIVIRIDAE, whose type species Beet curly top virus has a very wide host range.


A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.


Aminoaciduria, Renal
Renal Aminoacidurias

A group of inherited kidney disorders characterized by the abnormally elevated levels of AMINO ACIDS in URINE. Genetic mutations of transport proteins result in the defective reabsorption of free amino acids at the PROXIMAL RENAL TUBULES. Renal aminoaciduria are classified by the specific amino acid or acids involved.


Adrenergic beta-Receptors
Receptors, Adrenergic, beta
Receptor, Adrenergic, beta
Receptors, beta-Adrenergic
beta-Adrenergic Receptors

One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.


A deciduous shrub or small tree in the family Lythraceae, order Myrtales, superorder Rosanae. It bears edible reddish-purple fruit berries with seeds and pulp produced from the ovary of a single flower.


Immune Response, Mucosal
Mucosal Immunity
Immunity, Mucosal

Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.


alpha Integrins
Integrin alpha Chains
Integrin alpha Subunits

The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.


A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)


Azthreonam SQ-26,776 Aztreonam Az-threonam Azactam Urobactam

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.


Funding, Capital
Capital Financing
Financing, Capital

Institutional funding for facilities and for equipment which becomes a part of the assets of the institution.


Mercaptopropionylglycine
Meprin
Thiola
Tiopronine
Acadione
Captimer
Tiopronin
2-Mercaptopropionylglycine
Thiopronine
2-Thiol-propionamido-acetic Acid
alpha-Mercaptopropionylglycine
2-Thiolpropionamidoacetic Acid

Sulfhydryl acylated derivative of GLYCINE.


A plant genus of the family OLEACEAE. Members contain secoiridoid glucosides and this is the source of oil of jasmine.


Administration, Metronomic
Metronomic Drug Therapy
Metronomic Drug Administration

Administration of low doses of a drug or a drug combination over prolonged periods of time usually at a regular interval.


Individual's ability to manage the symptoms, treatment, physical and psychosocial consequences and lifestyle changes inherent in living with a chronic condition. Efficacious self-management encompasses ability to monitor one's condition and to affect the cognitive, behavioral, and emotional responses necessary to maintain a satisfactory quality of life.


Chemoreceptor Trigger Zone
Area Postrema

A small, rounded eminence on each side of the FOURTH VENTRICLE, which receives nerve fibers from the SOLITARY NUCLEUS; SPINAL CORD; and adjacent areas of the MEDULLA OBLONGATA. The area postrema lies outside the BLOOD-BRAIN BARRIER and its functions include acting as an emetic chemoreceptor.


A group of transmissible viral diseases of chickens and turkeys. Liver tumors are found in most forms, but tumors can be found elsewhere.


Targeted Temperature Management
Induced Hypothermia
Therapeutic Hypothermia
Mild Hypothermia, Induced
Hypothermia, Induced
Moderate Hypothermia, Induced

Body temperature of a patient is induced to 80-89 degree F or 27-32 C.


An enzyme that hydrolyzes galactose from ceramide monohexosides. Deficiency of this enzyme may cause globoid cell leukodystrophy (LEUKODYSTROPHY, GLOBOID CELL). EC 3.2.1.46.


Jet Lag
Time Zone Change Syndrome
Jet Lag Syndrome
Time Zone Syndrome

A chronobiologic disorder resulting from rapid travel across a number of time zones, characterized by insomnia or hypersomnolence, fatigue, behavioral symptoms, headaches, and gastrointestinal disturbances. (From Cooper, Sleep, 1994, pp593-8)


Trichothecenes, Type C
Type C Trichothecenes

A subclass of Trichothecene derivatives that includes the 12,13-epoxytrichothec-9-ene structure with an epoxide oxygen bond to the C7 and C8 carbon atoms.


Biological Pest Control
Biologic Pest Control
Pest Control, Biologic
Pest Control, Biological

Use of naturally-occuring or genetically-engineered organisms to reduce or eliminate populations of pests.


An enzyme that catalyzes the hydrolysis of a single fatty acid ester bond in lysoglycerophosphatidates with the formation of glyceryl phosphatidates and a fatty acid. EC 3.1.1.5.


Bone Demineralization, Pathologic
Pathologic Bone Demineralization

Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)


Fusion Regulatory Protein 1, Heavy Chain

A transmembrane glycoprotein subunit that can dimerize with a variety of light chain subunits such as SLC7A5; SLC7A6, and 4F2 LIGHT CHAINS. This protein subunit serves a diverse array of functions including amino acid transport and cell fusion. Its function is altered depending which of the light chain subunits it interacts with.


4,4,14 alpha-trimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol

A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.


Unconscious State
Unconsciousness
Consciousness, Loss of

Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)


A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.


Cress, Common Garden
Pepperweed
Peppergrass
Cress, Garden
Gardencress
Lepidium sativum

A plant species of the genus LEPIDIUM, family BRASSICACEAE that is a fast-growing, often weedy native of western Asia. It is widely grown, especially in its curl-leaved form, and used as a garnish


Glycogen Storage Disease Type I
Gierke's Disease
Glycogenosis 1
Glucosephosphatase Deficiency
Gierke Disease
Hepatorenal Glycogen Storage Disease
Deficiency, Glucosephosphatase
von Gierke Disease
von Gierke's Disease
Glucose-6-Phosphatase Deficiency
Glycogen Storage Disease 1 (GSD I)

An autosomal recessive disease in which gene expression of glucose-6-phosphatase is absent, resulting in hypoglycemia due to lack of glucose production. Accumulation of glycogen in liver and kidney leads to organomegaly, particularly massive hepatomegaly. Increased concentrations of lactic acid and hyperlipidemia appear in the plasma. Clinical gout often appears in early childhood.


Pentoxifylline Torental Agapurin Pentoxil Trental BL-191 Oxpentifylline

A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.


Nasolacrimal Duct Obstruction
Lacrimal Duct Obstruction
Tear Duct Obstruction

Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)


Neurological Nursing
Neuroscience Nursing

The nursing specialty focusing on the needs of patients with dysfunction of the NERVOUS SYSTEM.


Orthomyxoviruses
Influenza Viruses
Myxoviruses
Orthomyxoviridae

A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.


An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.


Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter

Solute Carrier Family 29 (Nucleoside Transporters), Member 1

Equilibrative NBMPR-Sensitive Nucleoside Transporter

A subtype of equilibrative nucleoside transporter proteins that is sensitive to inhibition by 4-nitrobenzylthioinosine.


Compounds that include the aminobenzene structure.


Human Parvovirus B19
Parvovirus B19, Human
B19 virus

The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.


High Speed Dental Equipment
Dental High-Speed Equipment

Tools used in dentistry that operate at high rotation speeds.


Visceroptosis
Visceral Prolapse
Splanchnoptosis

The prolapse or downward displacement of the VISCERA.


Periodic casting off FEATHERS; HAIR; or cuticle. Molting is a process of sloughing or desquamation, especially the shedding of an outer covering and the development of a new one. This phenomenon permits growth in ARTHROPODS, skin renewal in AMPHIBIANS and REPTILES, and the shedding of winter coats in BIRDS and MAMMALS.


Bridged-Ring Heterocyclic Compounds
Heterocyclic Compounds, Bridged-Ring

A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.


An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.


Croup-Associated Viruses
Para-Influenza Virus Type 2
Parainfluenza Virus 2, Human
Acute Laryngotracheo-Bronchitis Virus
Viruses, Croup-Associated
Acute Laryngotracheobronchitis Virus
Human parainfluenza virus 2
Virus, Croup-Associated
Croup-Associated Virus
Parainfluenza Virus Type 2

A species of RUBULAVIRUS associated particularly with acute laryngotracheitis (CROUP) in children aged 6 months to 3 years.


Anserine Beta-Alanyl-3-Methylhistidine Ophidine Balanine


Dental Prosthesis Implantation
Implantation, Dental Prosthesis
Prosthesis Implantation, Dental
Dental Implantation
Implantation, Dental

The grafting or inserting of a prosthetic device of alloplastic material into the oral tissue beneath the mucosal or periosteal layer or within the bone. Its purpose is to provide support and retention to a partial or complete denture.


A 145-kDa guanine nucleotide exchange factor that is specific for rap1 and ras GTP-BINDING PROTEINS. It associates with SH3 domains of the crk family of signaling proteins.


Cimex
Bedbugs
Cimex hemipterus
Cimex lectularius
Bed Bugs

Parasitic bugs of the family CIMICIDAE. Female bed bugs lay eggs in a sheltered locations such as in mattress seams. Adults and nymphal instars of Cimex feed on warm-blooded hosts. Cimex lectularius and Cimex hemipterus are implicated in human infestations.


Double-Stranded RNA
RNA, Double-Stranded

RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.


alpha-Galactosidase A Deficiency Disease

An X-linked inherited metabolic disease caused by a deficiency of lysosomal ALPHA-GALACTOSIDASE A. It is characterized by intralysosomal accumulation of globotriaosylceramide and other GLYCOSPHINGOLIPIDS in blood vessels throughout the body leading to multi-system complications including renal, cardiac, cerebrovascular, and skin disorders.


Deoxyadenosinecobalamins
Cobamides
Vitamin B12 Coenzymes
Vitamin B 12 Coenzymes


Cardiomyopathy, Alcoholic
Alcoholic Cardiomyopathy

Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).


Strip Biopsy
Endoscopic Mucosal Resection
Endoscopic Submucosal Dissection
Endoscopic Mucous Membrane Resection

A method for removing lesions from gastrointestinal MUCOUS MEMBRANES. The mucosal  tissue with the lesion is elevated by injecting a solution into the submucosal layer underneath it. Then a top layer of submucosal tissue below the fluid is dissected with an endoscopic scapel to remove the tissue with the lesion.


A macrolide antibiotic that has a wide antimicrobial spectrum and is particularly effective in respiratory and genital infections.


Male Genital Neoplasms
Neoplasms, Male Genital
Genital Neoplasms, Male


Sarcoma, Endometrial Stromal
Endometrial Stromal Sarcoma

A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).


Paraventricular Hypothalamic Nucleus
Paraventricular Nucleus
Hypothalamic Paraventricular Nucleus

Nucleus in the anterior part of the HYPOTHALAMUS.


Monocyte Chemotactic Activating Factor-2

A monocyte chemoattractant protein that attracts MONOCYTES; LYMPHOCYTES; BASOPHILS; and EOSINOPHILS. Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS.


Needlestick Injuries
Needlesticks
Injuries, Needlestick
Needle-Stick Injuries
Needle-Sticks
Sharps Injuries

Penetrating stab wounds caused by needles. They are of special concern to health care workers since such injuries put them at risk for developing infectious disease.


Leprosy, Macular
Leprosy, Neural
Leprosy, Tuberculoid
Tuberculoid Leprosy

A principal or polar form of LEPROSY in which the skin lesions are few and are sharply demarcated. Peripheral nerve involvement is pronounced and may be severe. Unlike lepromatous leprosy (LEPROSY, LEPROMATOUS), the lepromin test is positive. Tuberculoid leprosy is rarely a source of infection to others.


Limbless REPTILES of the suborder Serpentes.


A carpal bone adjacent to the TRAPEZOID BONE.


White Adipose Tissue
White Fat
Adipose Tissue, White

Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy.


Voltage-Gated K+ Channel KCNQ2
KCNQ2 Protein
Kv7.2 Potassium Channel
KCNQ2 Potassium Channel

A very slow opening and closing voltage-gated potassium channel that is expressed in NEURONS and is commonly mutated in BENIGN FAMILIAL NEONATAL CONVULSIONS.


Antileprotic Agents
Leprostatic Agents
Leprostatics

Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.


Fumaric Aminase
Aspartase
Aspartate Ammonia-Lyase

An enzyme that catalyzes the conversion of aspartic acid to ammonia and fumaric acid in plants and some microorganisms. EC 4.3.1.1.


Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)


Follow-on Biologics
Subsequent Entry Biologics
Biosimilar Pharmaceuticals
Biosimilars

Biological products that are imitations but not exact replicas of innovator biological products.


Hospitals, Branch
Branch Hospitals
Hospitals, Satellite
Satellite Hospitals

Those hospitals which are extensions of a main hospital and are wholly or partly administered by that hospital.


tRNA(Ala)
Transfer RNA, Ala
tRNAAla
RNA, Transfer, Ala
Alanine-Specific tRNA

A transfer RNA which is specific for carrying alanine to sites on the ribosomes in preparation for protein synthesis.


Arrest of cell locomotion or cell division when two cells come into contact.


Receptor, Lysosphingolipid
Lysosphingolipid Receptor
Lysosphingolipid Receptors
Receptors, Lysosphingolipid

A subfamily of lysophospholipid receptors with specificity for LYSOSPHINGOLIPIDS such as sphingosine-1-phosphate and sphingosine phosphorylcholine.


Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.


Ebola Virus Disease
Ebolavirus Infection
Ebola Hemorrhagic Fever
Ebola Infection
Ebola Virus Infection
Hemorrhagic Fever, Ebola

A highly fatal, acute hemorrhagic fever caused by EBOLAVIRUS.


Polyglycolic Acid
Dexon-S
Polyglycolide
Biofix
Dexon (Polyester)

A biocompatible polymer used as a surgical suture material.


Fibroma Virus, Rabbit
Shope Fibroma Virus
Rabbit Fibromatosis Virus
Rabbit Fibroma Virus
Fibromatosis Virus of Rabbits

A species of LEPORIPOXVIRUS causing subcutaneous localized swellings in rabbits, usually on the feet.


KCNQ3 Protein
Voltage-Gated K+ Channel KCNQ3
KCNQ3 Potassium Channel
Kv7.3 Potassium Channel

A very slow opening and closing voltage-gated potassium channel that is expressed in NEURONS and is closely related to KCNQ2 POTASSIUM CHANNEL. It is commonly mutated in BENIGN FAMILIAL NEONATAL CONVULSIONS.


Uroporphyrinogen III Cosynthetase
Uroporphyrinogen Isomerase
Cosynthase
Uroporphyrinogen-III Synthase
Uroporphyrinogen III Synthetase

An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and water. It is the fourth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by UROS gene. Mutations of UROS gene result in CONGENITAL ERYTHROPOIETIC PORPHYRIA.


RNA that has catalytic activity. The catalytic RNA sequence folds to form a complex surface that can function as an enzyme in reactions with itself and other molecules. It may function even in the absence of protein. There are numerous examples of RNA species that are acted upon by catalytic RNA, however the scope of this enzyme class is not limited to a particular type of substrate.


A highly poisonous organochlorine insecticide. The EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants. (From Merck Index, 11th ed)


Hernia Repair
Herniorrhaphy
Hernioplasty

Surgical procedures undertaken to repair abnormal openings through which tissue or parts of organs can protrude or are already protruding.


United States Employee Retirement Income Security Act

A 1974 Federal act which preempts states' rights with regard to workers' pension benefits and employee benefits. It does not affect the benefits and rights of employees whose employer is self-insured. (From Slee & Slee, Health Care Reform Terms, 1993)


4,4'-(Diethylideneethylene)diphenol
Dienoestrol
Dienestrol, (E,E)-Isomer
Dienestrol, (Z,Z)-Isomer
Ortho Dienestrol
Oestrasid
Dienestrol
Synestrol
Dienestrol, (Z,E)-Isomer

A synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms.


Ventilation Tests
Respiratory Airflow
Ventilation, Pulmonary
Pulmonary Ventilation
Expiratory Airflow

The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.


A cystic dilation of the EPIDIDYMIS, usually in the head portion (caput epididymis). The cyst fluid contains dead SPERMATOZOA and can be easily differentiated from TESTICULAR HYDROCELE and other testicular lesions.


FUS Protein
FUS RNA-Binding Protein
hnRNP P2
Fusion Protein in Myxoid Liposarcoma
TLS Protein
RNA-Binding Protein FUS
POMp75 Protein
Translocated in Liposarcoma Protein

A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.


Fractures, Cartilage
Cartilage Fractures


Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.


Carrying out of specific physical routines or procedures by one who is trained or skilled in physical activity. Performance is influenced by a combination of physiological, psychological, and socio-cultural factors.


Injections, Extradural
Peridural Injections
Extradural Injections
Injections, Peridural
Injections, Epidural
Epidural Injections

The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.


Undescended Testis
Cryptorchidism
Cryptorchidism, Unilateral Or Bilateral
Unilateral Cryptorchidism
Testis, Undescended
Inguinal Cryptorchidism
Bilateral Cryptorchidism
Abdominal Cryptorchidism
Cryptorchism
Testes, Undescended

A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.


Lyme Disease Spirochete
Borrelia burgdorferi sensu stricto
Borrelia burgdorferi

A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.


Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.


Truncus Arteriosus, Persistent
Persistent Truncus Arteriosus

A congenital anomaly caused by the failed development of TRUNCUS ARTERIOSUS into separate AORTA and PULMONARY ARTERY. It is characterized by a single arterial trunk that forms the outlet for both HEART VENTRICLES and gives rise to the systemic, pulmonary, and coronary arteries. It is always accompanied by a ventricular septal defect.


An agent used as a substrate in assays for cholinesterases, especially to discriminate among enzyme types.


Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.


Corpse Dismemberment
Cadaver Dismemberment

Disjoining the limbs or other parts of a corpse, often in association with criminal acts.


Secreted Matrix Metalloproteinases
Matrix Metalloproteinases, Secreted

A subclass of matrix metalloproteinases that are secreted into the pericellular space.


Mitochondrial Long Chain Enoyl CoA Hydratase 3 Hydroxyacyl CoA Dehydrogenase 3 Ketoacyl CoA Thiolase Trifunctional Protein

Mitochondrial Fatty Acid beta-Oxidation Trifunctional Protein

A mitochondrial protein consisting of four alpha-subunits and four beta-subunits. It contains enoyl-CoA hydratase, long-chain-3-hydroxyacyl-CoA dehydrogenase, and acetyl-CoA C-acyltransferase activities and plays an important role in the metabolism of long chain FATTY ACIDS.


Farming
Agricultural Development
Agriculture

The science, art or practice of cultivating soil, producing crops, and raising livestock.


Nanotubes, Carbon
Carbon Nanotubes
Nanoribbons
Buckytubes

Lengthwise cut and unzipped multiwalled carbon nanotubes.


Butyl Phthalate
Di-n-Butyl Phthalate
Dibutyl Phthalate

A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.


Bibliography, Descriptive
Descriptive Bibliographies
Bibliographies, Descriptive
Descriptive Bibliography

The area of bibliography which makes known precisely the material conditions of books, i.e., the full name of the author, the exact title of the work, the date and place of publication, the publisher's and printer's names, the format, the pagination, typographical particulars, illustrations, and the price, and for old books, other characteristics such as the kind of paper, binding, etc. It is also called analytical bibliography and physical bibliography. (Harrod's Librarians' Glossary, 7th ed)


A mitosporic Ophiostomataceae fungal genus, whose species Sporothrix schenckii is a well-known animal pathogen. The conidia of this soil fungus may be inhaled causing a primary lung infection, or may infect independently via skin punctures.


Inappropriate Prolactin Secretion Syndrome

Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)


Postsynaptic Potentials
Synaptic Potential
Postsynaptic Current
Synaptic Potentials

The membrane potentials across the SYNAPTIC MEMBRANES of the target cells of the NEUROTRANSMISSION pathway.


An egg yolk phosphoglycoprotein which contains about 90% of the yolk protein phosphorus. It is synthesized in the liver of the hen and transferred to the developing oocyte, where it is bound to lipoproteins within the yolk granules.


Epoxide Hydratases
9,10-Epoxypalmitic Acid Hydrase
Microsomal Epoxide Hydrolase
Styrene Epoxide Hydrolase
Epoxide Hydrolases
Epoxide Hydrases

Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.


A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.


Factor IXa
Factor Nine A
Coagulation Factor IXa
Factor IX, Activated
Blood Coagulation Factor IX, Activated
Factor 9A

Activated form of factor IX. This activation can take place via the intrinsic pathway of blood coagulation by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.


Pseudoautosomal Regions
Pseudoautosomal Region

Homologous chromosomal regions at either end of the X CHROMOSOME or Y CHROMOSOME. These two regions pair regularly at male MEIOSIS and undergo RECOMBINATION. Pseudoautosomal region 1 (PAR1) is located  at the tip of the short 'p' arms (Xp22 and Yp11) and Pseudoautosomal region 2 (PAR2) is located at the tip of the long 'q' arms (Xq28 and Yq12).


Receptors, Calcitonin
Calcitonin Receptors
Calcitonin Receptor

Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.


Mouse, NOD
Mice, NOD
Non-Obese Diabetic Mouse
Nonobese Diabetic Mouse
Mice, Inbred NOD
Mouse, Inbred NOD
Non-Obese Diabetic Mice
Nonobese Diabetic Mice

A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.


Latent Variable Modeling
Structural Equation Modeling
Latent Class Model
Latent Class Analysis
Probabilistic Latent Semantic Analysis

A statistical algorithm used to analyze clusters of observed variables by constructing categorical unobserved or latent segment based on weighted analysis and the average probabilities. Such latent classes are used to infer variables whose relationships are not directly observed. In biomedical research, it is often used to categorize data that allows the determination of symptom clusters.


Tumor Necrosis Factor Ligand Superfamily Member 8

A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. It may play a role in INFLAMMATION and immune regulation.


A pyrano-acridone alkaloid found in RUTACEAE plants.


A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes.


Centaurea
Thistle, Yellow Star
Knapweed
Thistle, Red Star
Cornflower

A plant genus of the family ASTERACEAE. Members contain 5-methyl-8-hydroxycoumarin. The common name of centaury is more often used for CENTAURIUM


Ocular Distance Accommodation
Accommodation, Ocular
Accommodation, Lens
Ocular Accommodation


Endothelin A Receptors
Endothelin Receptors Type A
Receptor, Endothelin-1
Receptor, Endothelin A

A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.


RC3 Protein (Neurogranin)
P17 Protein Kinase C Substrate
Neurogranin

A BRAIN-specific substrate for PROTEIN KINASE C that binds CALMODULIN and is involved in regulation of CALCIUM SIGNALING.


Subject matter related to research studies in which the data do not demonstrate any clear evidence of effect, especially if an effect was expected.


Midges, Biting
Ceratopogonidae
Culicoides
Leptoconops

A family of biting midges, in the order DIPTERA. It includes the genus Culicoides which transmits filarial parasites pathogenic to man and other primates.


Health Services Needs and Demand
Needs
Target Population
Needs and Demand, Health Services
Health Services Needs

Health services required by a population or community as well as the health services that the population or community is able and willing to pay for.


A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.


Gases that irritate the eyes, throat, or skin. Severe lacrimation develops upon irritation of the eyes.


Eye Movement Desensitization Reprocessing

Eye Movement Desensitization and Processing

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.


A group of ANTI-BACTERIAL AGENTS characterized by a chromophoric naphthohydroquinone group spanned by an aliphatic bridge not previously found in other known ANTI-BACTERIAL AGENTS. They have been isolated from fermentation broths of Streptomyces mediterranei.


Cavernitis, Fibrous
Penile Induration
Peyronie Disease
Peyronie's Disease
Penile Fibromatosis
Plastic Induration of the Penis

A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.


Manganese derivative of ethylenebisdithiocarbamate. It is used in agriculture as a fungicide and has been shown to cause irritation to the eyes, nose, skin, and throat.


The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.


Sodium-Phosphate Symporter Proteins, Type IIc

Sodium-Phosphate Cotransporter Proteins, Type IIc

Type IIc Sodium-Phosphate Symporter Proteins

Type IIc Sodium-Phosphate Cotransporter Proteins

A non-electrogenic sodium-dependent phosphate transporter. It is found primarily in apical membranes of PROXIMAL RENAL TUBULES.


A genus of the family Heteromyidae which contains 22 species. Their physiology is adapted for the conservation of water, and they seldom drink water. They are found in arid or desert habitats and travel by hopping on their hind limbs.


Immunocompetence
Immunologic Competence
Immunological Competence
Competence, Immunologic

The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.


A plant genus of the family RUTACEAE. Members contain ponfolin, a coumarin (COUMARINS).


The joining of pieces of metal through the use of an alloy which has a lower melting point, usually at least 100 degrees Celsius below the fusion temperature of the parts being soldered. In dentistry, soldering is used for joining components of a dental appliance, as in assembling a bridge, joining metals to orthodontic bands, or adding to the bulk of certain structures, such as the establishment of proper contact areas on inlays and crowns with adjacent teeth. (Illustrated Dictionary of Dentistry, 1982)


Clonorchis sinensis
Opisthorchis sinensis

A species of trematode flukes of the family Opisthorchidae. Many authorities consider this genus belonging to Opisthorchis. It is common in China and other Asiatic countries. Snails and fish are the intermediate hosts.


Herpes Simplex Virus Trans-Activator Vmw65

Herpes Simplex Virus Type 2 Protein VP16

Herpes Simplex Virus Transcriptional Activator Vmw65

alpha-Trans-Inducing Factor, Herpes Simplex Virus 1

Trans-acting protein that combines with host factors to induce immediate early gene transcription in herpes simplex virus.


Sticks used as walking aids. The canes may have three or four prongs at the end of the shaft.


Neoadjuvant Therapy
Neoadjuvant Treatment

Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.


Cost Shifting
Cost Allocation
Cost Apportionment

The assignment, to each of several particular cost-centers, of an equitable proportion of the costs of activities that serve all of them. Cost-center usually refers to institutional departments or services.


The forcible expulsion of the contents of the STOMACH through the MOUTH.


Amino Acid Transport System y-Plus
System y+ Transporter
Amino Acid Transport System y+

A sodium-independent, basic amino acid transport system with a high-affinity for LYSINE; ARGININE; and ORNITHINE.


Pituitary Irradiation
Pituitary Gland Irradiation

Radiation therapy used to treat the PITUITARY GLAND.


A strain of MURINE LEUKEMIA VIRUS associated with mouse tumors similar to those caused by the FRIEND MURINE LEUKEMIA VIRUS. It is a replication-competent murine leukemia virus. It can act as a helper virus when complexing with a defective transforming component, RAUSCHER SPLEEN FOCUS-FORMING VIRUS.


Techniques used for removal of bonded orthodontic appliances, restorations, or fixed dentures from teeth.


Heterocyclic compounds that contain 4H,5H,6H,7H-thieno[2,3-c]pyridine as part of their structure.


PPIC Protein
Peptidylprolyl Isomerase C
Rotamase C
Cyclophilin C
Peptidyl-Prolyl Cis-Trans Isomerase C

A peptidyl-prolyl cis-trans isomerase and member of the cyclophilin family. It catalyzes the cis-trans isomerization of imide-like peptide bonds that occur between PROLINE and other amino acids to facilitate PROTEIN FOLDING.


3-Hydroxy-N-methylmorphinan
Levo-Dromoran
Levorphanol Tartrate
L-Dromoran
Levorphan
Levorphanol
Levodroman

A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.


Anomic Dysphasia
Aphasia, Nominal
Nominal Dysphasia
Color Anomia
Aphasia, Amnesic
Aphasia, Anomic
Dysnomia
Anomia

A language dysfunction characterized by the inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name. This condition is associated with lesions of the dominant hemisphere involving the language areas, in particular the TEMPORAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, p484)


An indicator and reagent. It has been used for several purposes including the determination of serum albumin concentrations


Coagulation Protein Disorders
Coagulation Proteins Disorders
Blood Coagulation Factor Deficiencies

Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.


Luteal Phase
Postovulatory Phase
Menstrual Cycle, Secretory Phase
Menstrual Cycle, Luteal Phase
Menstrual Secretory Phase

The period in the MENSTRUAL CYCLE that follows OVULATION, characterized by the development of CORPUS LUTEUM, increase in PROGESTERONE production by the OVARY and secretion by the glandular epithelium of the ENDOMETRIUM. The luteal phase begins with ovulation and ends with the onset of MENSTRUATION.


A diet that includes foods with a high protein content.


Neoplastic Pregnancy Complications
Pregnancy Complications, Neoplastic
Complications, Neoplastic Pregnancy
Pregnancy, Neoplastic Complications

The co-occurrence of pregnancy and NEOPLASMS. The neoplastic disease may precede or follow FERTILIZATION.


A branch of nursing requiring generalist training with specialty knowledge in crisis assessment and management in all subdisciplines of nursing. Rural nursing practices often include geographical and social distance concepts in delivery of health care.


Adolescent Psychology
Psychology, Adolescent

Field of psychology involving the study of normal and abnormal behavior of adolescents. It includes mental processes as well as observable responses.


Methoxone
2-Methyl-4-chlorophenoxyacetic Acid
MCPA
Agroxone

A powerful herbicide used as a selective weed killer.


Mitochondrial Uncoupling Protein 3
UCP3 Protein
Uncoupling Protein 3
SLC25A9 Protein
Solute Carrier Family 25 Member 9
Uncoupling Protein-3

A mitochondrial uncoupling protein that is expressed in heart and skeletal muscle tissues. It functions to regulate tissue respiration, energy balance, and THERMOGENESIS. Mutations in the UCP3 gene are associated with OBESITY.


Tumor-Cell Human GM Colony-Stimulating Factor

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.


Telangiectasia
Spider Veins
Telangiectasis

Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.


A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)


Common Acute Lymphoblastic Leukemia Antigens

Antigens, Leukemia, Common Acute Lymphoblastic

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.


Hepatic Infarction
Hepatic Infarct
Liver Infarct
Liver Infarction

Formation of infarct resulting from obstruction of HEPATIC ARTERY and/or PORTAL VEIN most often after LIVER TRANSPLANTATION or hepatobiliary surgery.


A species of virus (unassigned to a genus) in the family FLAVIVIRIDAE, that have been identified in at least six species of New World monkeys. They do not cause HEPATITIS in the host or other susceptible species.


Psychotherapy used for either unmarried couples or married couples, of mixed or same sex.


Method of psychotherapeutic treatment based on assumption of patients' personal responsibility for their own behavior. The therapist actively guides patients to accurate self-perception for fulfillment of needs of self-worth and respect for others. (From APA, Thesaurus of Psychological Index Terms, 8th ed.)


Pyruvate Dehydrogenase Phosphate Phosphatase

(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. EC 3.1.3.43.


Checking Accounts
Bank Accounts
Banking, Personal
Banking, Commercial
Savings Accounts
Banking, Financial

A financial account set up between a financial institution (such as a commercial bank) and a customer (individual, group, or business), whereby the latter may deposit and withdraw money, and where applicable, be paid interest.


Balloon Angioplasty
Angioplasty, Balloon
Dilation, Transluminal Arterial

Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.


beta-N-Acetylglucosaminidase N-Ac-beta-Glucosaminidase Acetylglucosaminidase N,N-Diacetylchitobiase NAGase beta-D-N-acetylglucosaminidase Chitobiase beta-D-Acetamido-2-Deoxyglucosidase N-Acetyl-beta-D-glucosaminidase

A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.


MutS DNA Mismatch-Binding Protein
DNA Mismatch Repair Protein MutS

A methyl-directed mismatch DNA REPAIR protein that has weak ATPASE activity. MutS was originally described in ESCHERICHIA COLI.


Marek Disease Vaccines
Marek's Disease Vaccines

Vaccines or candidate vaccines used to prevent MAREK DISEASE, an avian disease caused by a herpesvirus.


Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.


Fat Emulsions, Intravenous
Lipid Emulsions, Intravenous

Emulsions of fats or lipids used primarily in parenteral feeding.


A form of LEPROSY in which there are clinical manifestations of both principal types (lepromatous and tuberculoid). The disease may shift toward one of these two polar or principal forms.


Basal Cell Neoplasms
Basal Cell Cancer
Neoplasms, Basal Cell

Neoplasms composed of cells from the deepest layer of the epidermis. The concept does not refer to neoplasms located in the stratum basale.


Bad Protein
bcl-Associated Death Protein
bcl2-Antagonist of Cell Death Protein

A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.


Dwarfism, Thanatophoric
Thanatophoric Dwarfism
Thanatophoric Dysplasia
Thanatophoric Short Stature

A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.


Errors, Diagnostic
Diagnostic Errors
Misdiagnosis

Incorrect conclusion as to source or cause of illness.


Behavior Therapy
Therapy, Behavior
Behavior Modification
Conditioning Therapy
Therapy, Conditioning

The application of modern theories of learning and conditioning in the treatment of behavior disorders.


beta-Alanine Pyruvate Aminotransferase
beta-Alanine-Pyruvate Transaminase
beta-Alanine - Pyruvate Transaminase

A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of an amino group from L-ALANINE to 3-oxopropanoate to generate PYRUVATE and BETA-ALANINE.


Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.


ReoPro
c7E3 Fab
Clotinab
Chimeric 7E3 Fab
CentoRx
Abciximab

A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. It is used in treatment of refractory unstable angina, and for prevention of ischemic complications in patients undergoing percutaneous coronary procedures such as ANGIOPLASTY; ATHERECTOMY; or stenting.


The process by which the nature and meaning of gustatory stimuli are recognized and interpreted by the brain. The four basic classes of taste perception are salty, sweet, bitter, and sour.


Silimarin Silymarin Legalon Carsil Karsil

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.


Tobacco Use Cessation
Tobacco Cessation
Smokeless Tobacco Cessation

Ending the TOBACCO habits of smoking, chewing, or snuff use.


The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.


Hospitals which provide care for a single category of illness with facilities and staff directed toward a specific service.


2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.


Polychlorotriphenyl Compounds
Polychloroterphenyl Compounds

Compounds consisting of three benzene rings linked to each other in either ortho, meta or para positions and substituted with chlorine atoms.


Food Allergy
Allergy, Food
Food Hypersensitivity
Hypersensitivity, Food

Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.


Narcoleptic Syndrome
Gelineau Syndrome
Narcolepsy
Narcolepsy-Cataplexy Syndrome
Paroxysmal Sleep
Gelineau's Syndrome

A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)


Milieu Therapy
Therapy, Situational
Therapy, Milieu
Situational Therapy

A treatment program based on manipulation of the patient's environment by the medical staff. The patient does not participate in planning the treatment regimen.


A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.


The major group of transplantation antigens in the mouse.


A class of Echinodermata characterized by long, slender bodies.


Premature Obstetric Labor
Labor, Premature
Premature Labor
Preterm Labor
Obstetric Labor, Premature

Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE).


General or unspecified injuries involving organs in the abdominal cavity.


Cerebellar Dysfunction
Cerebellar Diseases
Cerebellar Syndromes
Cerebellum Diseases
Cerebellar Disorders

Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.


Aspartyl Aminopeptidase
Aspartate Aminopeptidase
Aminopeptidase A
Angiotensinase A
Glutamyl Aminopeptidase

A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM.


A sheath that is worn over the penis during sexual behavior in order to prevent pregnancy or spread of sexually transmitted disease.


The rate at which steps are made while walking.


Methyl N-alpha-Tosyl-L-Arginate
Tosylarginine Methyl Ester

Arginine derivative which is a substrate for many proteolytic enzymes. As a substrate for the esterase from the first component of complement, it inhibits the action of C(l) on C(4).


White spot syndrome virus 1
White Spot Syndrome Virus

A species of DNA virus, in the genus WHISPOVIRUS, infecting PENAEID SHRIMP.


A plant genus of the family ANNONACEAE known for its aromatic oil (OILS, VOLATILE).


A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.


A bundle of MICROTUBULES and MICROTUBULE-ASSOCIATED PROTEINS forming the core of each CILIUM or FLAGELLUM. In most eukaryotic cilia or flagella, an axoneme shaft has 20 microtubules arranged in nine doublets and two singlets.


A phosphatidylinositol 3-kinase that catalyzes the conversion of 1-phosphatidylinositol 4-phosphate into phosphatidylinositol 3,4-bisphosphate.


Veratrum nigrum
Veratrum
Hellebore, False

A plant genus of the family Melanthiaceae with roots that contain VERATRUM ALKALOIDS used as emetics, parasiticides, antihypertensives. The common name "black hellebore" is used for both Veratrum nigrum and HELLEBORUS NIGER.


An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.


CD4-Positive T-Lymphocytes
T4 Cells
CD4-Positive Lymphocytes
T4 Lymphocytes

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.


Intraarticular Injections
Intra-Articular Injections
Injections, Intraarticular
Injections, Intra-Articular

Methods of delivering drugs into a joint space.


Anesthesia, Refrigeration
Refrigeration Anesthesia
Cryoanesthesia

ANESTHESIA achieved by lowering either BODY TEMPERATURE (core cooling) or SKIN TEMPERATURE (external cooling).


NADP+ Specific 8-Glutamate Semialdehyde Dehydrogenase

An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.


A plant genus of the family SAXIFRAGACEAE with dark green round or heart-shaped leaves and tiny flowers.


Light-Chain Immunoglobulins
Immunoglobulin Light Chain
Immunoglobulin Light-Chain
Ig Light Chains
Immunoglobulins, Light-Chain
Immunoglobulin Light Chains

Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.


Environmental Pollution
Soil Pollution
Pollution, Environmental

Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.


A multiribosomal structure representing a linear array of RIBOSOMES held together by messenger RNA; (RNA, MESSENGER); They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)


Gall Bladder Diseases
Gallbladder Diseases

Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.


Third Party Consent
Spousal Consent
Community Consent
Third-Party Consent

Consent by a population group or its representative as proxy. Examples include a tribe, a village, or a town or city council.


A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.


Prescription Monitoring
Prescription Drug Monitoring Program
Prescription Drug Monitoring Programs

Programs, usually run by state governments, that require pharmacists to collect and distribute data on the prescription and dispensation of CONTROLLED SUBSTANCES. They are intended to prevent the abuse of such substances by the patient, or their transfer to recreational users and drug dealers.


Mental Health Rehabilitation
Psychiatric Rehabilitation
Psychosocial Rehabilitation

Specialty field that promotes recovery, community functioning, and increased well-being of individuals diagnosed with mental disorders that impair their ability to live meaningful lives.


Ethical Codes
Ethical Oaths
Codes of Ethics
Code of Ethics
Codes of Professional Ethics
Ethical Directives

Systematic statements of principles or rules of appropriate professional conduct, usually established by professional societies.


Vesicular Glutamate Transporter Proteins

A family of vesicular neurotransmitter transporter proteins that were originally characterized as sodium dependent inorganic phosphate cotransporters. Vesicular glutamate transport proteins sequester the excitatory neurotransmitter GLUTAMATE from the CYTOPLASM into SECRETORY VESICLES in exchange for lumenal PROTONS.


Thioredoxin-Disulfide Reductase
NADPH-Thioredoxin Reductase
Thioredoxin Reductase (NADPH)
NADP-Thioredoxin Reductase
Thioredoxin Reductase

A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 1.6.4.5


AIDS Seropositivity
HTLV-III Seropositivity
HTLV-III Seroconversion
AIDS Seroconversion
HIV Seroconversion
Anti-HIV Positivity
HIV Seropositivity
HIV Antibody Positivity

Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV).


Metabolic Activation
Drug Activation
Activation, Metabolic

The conversion of an exogenous substance by a biological system resulting in the production on an active metabolite.


ADP-ATP Carrier Protein, Liver Isoform T2

ADP, ATP Carrier Protein, Liver Isoform T2

Solute Carrier Family 25 (Mitochondrial Carrier - Adenine Nucleotide Translocator), Member 6

A subtype of mitochondrial ADP, ATP translocase found primarily in the LIVER.


Plasma Cell Granuloma of Lung
Inflammatory Pulmonary Pseudotumor
Pulmonary Plasma Cell Granuloma
Pulmonary Inflammatory Pseudotumor
Inflammatory Pseudotumor of Lung
Pulmonary Pseudotumor, Inflammatory
Pulmonary Granuloma, Plasma Cell
Pseudotumor, Pulmonary Inflammatory
Pseudotumor, Inflammatory, Pulmonary
Granuloma, Plasma Cell, Pulmonary
Plasma Cell Granuloma, Pulmonary
Inflammatory Pseudotumor, Pulmonary

A tumor-like inflammatory lesion of the lung that is composed of PLASMA CELLS and fibrous tissue. It is also known as an inflammatory pseudotumor, often with calcification and measuring between 2 and 5 cm in diameter.


A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.


A genus of the LAMIACEAE family. It is known for its mild calming effect and for the way cats are attracted to the aroma.


NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases

Alchohol Oxidoreductases, NAD (+) and NADP (+) Dependent

Oxidoreductases that act on the CH-OH group of donors with NAD (+) or NADPH (+) as acceptors.


Intraabdominal Infections
Intra-Abdominal Infections

Infection within the PERITONEAL CAVITY. A frequent cause is an ANASTOMOTIC LEAK following surgery.


A subfamily of POXVIRIDAE comprising poxviruses infecting insects including members of COLEOPTERA; DIPTERA; LEPIDOPTERA; and ORTHOPTERA.


Active Biological Transport
Active Transport
Biological Transport, Active
Biologic Transport, Active
Transport, Active Biological
Uphill Transport

The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.


A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).


Bajra
Millet, Pearl
Pennisetum
Grass, Fountain
Fountaingrass

A plant genus of the family POACEAE. The seed is one of the millets used in EDIBLE GRAIN. It contains vitexin. The common name of buffelgrass is also used for CENCHRUS.


Phytohormones
Plant Growth Regulators
Growth Regulators, Plant
Plant Hormones
Regulators, Plant Growth

Any of the hormones produced naturally in plants and active in controlling growth and other functions. There are three primary classes: auxins, cytokinins, and gibberellins.


Antiphospholipid Antibodies
Antibodies, Antiphospholipid
Antiphospholipid Antibody

Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.


Protein-Tyrosine Kinases, src
src-Family Kinases
src Kinases
src-Family Tyrosine Kinases
src Tyrosine Kinases

A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.


Phenylmercury Compounds
Phenylmercurials
Phenyl Mercury Compounds

Organic mercury compounds in which the mercury is attached to a phenyl group. Often used as fungicides and seed treatment agents.


Herpetic Geniculate Ganglionitis
Geniculate Herpes Zoster
Ramsay Hunt Auricular Syndrome
Herpes Zoster Auricularis
Neuralgia, Geniculate
Auricular Syndrome of Ramsay Hunt
Herpes Zoster Cephalicus
Ramsay Hunt Syndrome
Herpes Zoster Oticus

A syndrome characterized by facial palsy in association with a herpetic eruption of the external auditory meatus. This may occasionally be associated with tinnitus, vertigo, deafness, severe otalgia, and inflammation of the pinna. The condition is caused by reactivation of a latent HERPESVIRUS 3, HUMAN infection which causes inflammation of the facial and vestibular nerves, and may occasionally involve additional cranial nerves. (From Adams et al., Principles of Neurology, 6th ed, p757)


A plant genus of the family RUTACEAE. Members contain BERBERINE, indolopyridoquinazoline and other ALKALOIDS and limonoids.


A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.


The farthest or outermost projections of the body, such as the HAND and FOOT.


Acute Kidney Tubular Necrosis
Kidney Tubular Necrosis, Acute
Lower Nephron Nephrosis

Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.


Catarrh
Common Cold
Cold, Common
Coryza, Acute

Inflammation of a mucous membrane with increased flow of mucous in humans or animals. Catarrh is used mostly in a historical context.


bnAbs
Cross-Neutralizing Antibodies
Broadly Neutralizing Antibodies
Broad Spectrum Antibodies
Broad Neutralizing Antibodies

Neutralizing antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent (e.g., HIV) by targeting several epitopes.


Happy Puppet Syndrome
Angelman Syndrome
Puppet Children

A syndrome characterized by multiple abnormalities, MENTAL RETARDATION, and movement disorders. Present usually are skull and other abnormalities, frequent infantile spasms (SPASMS, INFANTILE); easily provoked and prolonged paroxysms of laughter (hence "happy"); jerky puppetlike movements (hence "puppet"); continuous tongue protrusion; motor retardation; ATAXIA; MUSCLE HYPOTONIA; and a peculiar facies. It is associated with maternal deletions of chromosome 15q11-13 and other genetic abnormalities. (From Am J Med Genet 1998 Dec 4;80(4):385-90; Hum Mol Genet 1999 Jan;8(1):129-35)


Group E Chromosomes
Chromosomes, Human, 16-18
Chromosomes E

The short, submetacentric human chromosomes, called group E in the human chromosome classification. This group consists of chromosome pairs 16, 17, and 18.


Triquetral Bone
Triquetrum Bone
Os Triquetrum

A carpal bone which is located between the LUNATE BONE and HAMATE BONE.


Transistors, Electronic
Electronic Transistors

Electrical devices that are composed of semiconductor material, with at least three connections to an external electronic circuit. They are used to amplify electrical signals, detect signals, or as switches.


The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.


A ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS.


Lymphocyte Function Associated Antigen-3

Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on MACROPHAGES. CD58 mediates cell adhesion by binding to CD2; (CD2 ANTIGENS); and this enhances antigen-specific T-cell activation.


Area in an environment in which a population of organisms can survive through a period of unfavorable conditions.


Prairie Steppe Grassland Meadows Savanna

An ecosystem dominated by grasses (POACEAE) with few trees or shrubs.


A non-metabolizable galactose analog that induces expression of the LAC OPERON.


gag-myc Fused Protein p110
Fusion Proteins, gag-onc
p140 gag-fps
p200 gag-pol-myc
Fusion Proteins, gag-ros
p140 gag-fes
Fujinami Sarcoma Virus P140 gag-fps
gag-onc Fusion Proteins
pp85 gag-fes
Oncogene Protein v-fes

General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.


The largest inland body of water, located between ASIA and EUROPE.


A PROTEIN O-METHYLTRANSFERASE that recognizes and catalyzes the methyl esterification of ISOASPARTIC ACID and D-ASPARTIC ACID residues in peptides and proteins. It initiates the repair of proteins damaged by the spontaneous decomposition of normal L-aspartic acid and L-asparagine residues.


Encephalomyelitis Virus, Venezuelan Equine

A species of ALPHAVIRUS that is the etiologic agent of encephalomyelitis in humans and equines. It is seen most commonly in parts of Central and South America.


Anesthetics, Inhalation
Inhalation Anesthetics
Anesthetic Gases

Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)


Duration of Treatment
Duration of Therapy

Planned or actual duration of various treatments or preventive measures.


Breast Cancer Anti-Estrogen Resistance 1 Protein

A highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.


Chemotactic Cytokines
Chemokines
Cytokines, Chemotactic
Intercrines

Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.


NADPH-Cytochrome P450 Reductase
Ferrihemoprotein P450 Reductase
NADPH-Ferrihemoprotein Reductase
NADPH Cytochrome P450 Oxidoreductase
Cytochrome P-450 Reductase
Cytochrome P450 Reductase
Cytochrome P-450 Oxidase
NADPH Cytochrome c Reductase
NADPH-P450 Reductase
NADPH Cytochrome P450 Reductase
NADPH Cytochrome P-450 Oxidoreductase
NADPH Cytochrome P-450 Reductase
Ferrihemoprotein P-450 Reductase

A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.


Helicobacter Infections
Infections, Helicobacter

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.


PARK7 Protein
DJ-1 Protein
Parkinsonism Associated Deglycase
DJ-1-PARK7 Protein
Protein Deglycase DJ-1
DJ1 Protein
Parkinson Protein 7

A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.


Coefficient of Conductivity
Thermal Conductivity
Heat Conductivity

The heat flow across a surface per unit area per unit time, divided by the negative of the rate of change of temperature with distance in a direction perpendicular to the surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


Cyclin-Dependent Kinase Inhibitor p16
p16INK4A Protein
CDKN2 Protein
CDKN2A Protein
Cyclin-Dependent Kinase Inhibitor-2A
Cdk4-Associated Protein p16
p16(INK4A)
p16INK4 Protein
MTS1 Protein
Multiple Tumor Suppressor-1
INK4A Protein

A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.


Thiobacillus thiooxidans
Acidithiobacillus thiooxidans

A strictly autotrophic species of bacteria that oxidizes sulfur and thiosulfate to sulfuric acid. It was formerly called Thiobacillus thiooxidans.


A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.


The etiologic agent of PLAGUE in man, rats, ground squirrels, and other rodents.


BALB-3T3 Cells
BALB 3T3 Cells
BALB-c 3T3 Cells
3T3 Cells, BALB
BALB 3T3 clone A31

Cell lines developed from disaggregated BALB/c mouse embryos. They are extremely sensitive to CONTACT INHIBITION, and highly susceptible to transformation by SV40 VIRUS and murine sarcoma virus (SARCOMA VIRUSES, MURINE).


A serotype of the species California encephalitis virus (ENCEPHALITIS VIRUS, CALIFORNIA), in the genus ORTHOBUNYAVIRUS, causing human MENINGOENCEPHALITIS. This is the agent most responsible for California encephalitis (ENCEPHALITIS, CALIFORNIA), the most prevalent mosquito-borne disease recognized in the United States.