Antisense Oligoribonucleotide
Anti-Sense Oligoribonucleotide
Oligoribonucleotides, Antisense
Antisense OligoRNA
Oligoribonucleotide, Antisense
Anti-Sense Oligoribonucleotides
Antisense Oligoribonucleotides

Short fragments of RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.


Morvan's Chorea
Morvan's Fibrillary Chorea
Myokymia, Generalized
Fibrillary Chorea
Kymatism
Myokymia
Morvan Chorea

Successive and rapid contractions of motor units associated with chronic nerve injury. The discharges arise from the peripheral aspects of regenerating nerves, and clinically impart a nearly continuous undulation of the body surface overlying the muscle. (Adams et al., Principles of Neurology, 6th ed, p1491)


A plant genus in the family THEACEAE, order ERICALES best known for CAMELLIA SINENSIS which is the source of Oriental TEA.


Prior Authorization
Pre-Authorization
Pre-Approval
Prior Approval

A decision by a health insurer or plan that a health care service, treatment plan, prescription drug or durable medical equipment is medically necessary.


Glioblastoma Multiforme
Astrocytoma, Grade IV
Glioblastoma
Giant Cell Glioblastoma

A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.


Pars Distalis of Pituitary
Anterior Lobe of Pituitary
Lobus Anterior
Anterior Pituitary Gland
Pituitary Gland, Anterior
Adenohypophysis

The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.


Smad2 Protein
MADR2 Protein
MAD-Related 2 Protein

A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. It regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.


Salmonella Bacteriophages
Salmonella Phages

Viruses whose host is Salmonella. A frequently encountered Salmonella phage is BACTERIOPHAGE P22.


In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.


Green Non-Sulfur Bacteria
Bacteria, Green Non-Sulfur
Bacteria, Green Nonsulfur
Chloroflexaceae
Green Nonsulfur Bacteria
Herpetosiphon
Chloroflexi

A genus of nonphotosynthetic, aerobic, chemoorganotrophic bacteria in the family Herpetosiphonaceae, found in fresh water and soil.


Swine Fever Virus, Classical
Swine Fever Virus
Classical Swine Fever Virus
Hog Cholera Virus

A species of the PESTIVIRUS genus causing exceedingly contagious and fatal hemorrhagic disease of swine.


Aminocyclopentanecarboxylic Acid
1-Aminocyclopentanecarboxylic Acid
Cycloleucine
NSC 1026

An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.


Ganglioside GM2
Tay-Sachs Disease Ganglioside
GM2 Ganglioside
G(M2) Ganglioside

A glycosphingolipid that accumulates due to a deficiency of hexosaminidase A or B (BETA-N-ACETYLHEXOSAMINIDASES), or GM2 activator protein, resulting in GANGLIOSIDOSES, heredity metabolic disorders that include TAY-SACHS DISEASE and SANDHOFF DISEASE.


Nexin, Protease-Associated
Nexin, Protease
Protease Nexins

Extracellular protease inhibitors that are secreted from FIBROBLASTS. They form a covalent complex with SERINE PROTEASES and can mediate their cellular internalization and degradation.


Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.


Galactopyranose D-Galactose Galactopyranoside Galactose

An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.


Inositol Oxygenase
Myo-Inositol Oxygenase

A non-heme IRON enzyme that catalyzes the conversion of MYOINOSITOL to D-glucuronic acid. The reaction is the first committed step in MYOINOSITOL catabolic pathway. This enzyme was formerly characterized as EC 1.13.1.11 and 1.99.2.6.


Asthenozoospermia
Asthenoteratozoospermia
Astheno Teratozoospermia

A condition in which the percentage of motile sperm is abnormally low.


Cervical Cord
Cervical Spinal Cord
Phrenic Nucleus
Accessory Nucleus

The segment of the spinal cord within the CERVICAL VERTEBRAE.


A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.


Sphingosine 1 Phosphate Receptor Modulators

Agents that affect the function of G-protein coupled SPHINGOSINE 1-PHOSPHATE RECEPTORS. Their binding to the receptors blocks lymphocyte migration and are often used as IMMUNOSUPPRESSANTS.


Insurance providing for payment of a stipulated sum to a designated beneficiary upon death of the insured.


Immunodeficiency, Microcephaly, And Chromosomal Instability

Nonsyndromal Microcephaly, Autosomal Recessive, with Normal Intelligence

Microcephaly with Normal Intelligence, Immunodeficiency, and Lymphoreticular Malignancies

A chromosome instability syndrome resulting from a defective response to DNA double-strand breaks. In addition to characteristic FACIES and MICROCEPHALY, patients have a range of findings including RADIOSENSITIVITY, immunodeficiency, increased cancer risk, and growth retardation. Causative mutations occur in the NBS1 gene, located on human chromosome 8q21. NBS1 codes for nibrin, the key regulator protein of the R/M/N (RAD50/MRE11/NBS1) protein complex which senses and mediates cellular response to DNA DAMAGE caused by IONIZING RADIATION.


Phosphatidylglycerols
Monophosphatidylglycerols
Glycerol Phosphoglycerides
Phosphatidyl Glycerol

A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.


Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.


Stearoyl CoA Hydrolase
Thioesterase I
Palmitoyl CoA Deacylase
Long-Chain Fatty-Acyl-CoA Hydrolase
Palmitoyl Thioesterase
Oleoyl-CoA Acylhydrolase
Palmitoyl Coenzyme A Hydrolase
Palmitoyl-CoA Hydrolase
Fatty Acyl Thioesterase
Acyl CoA Hydrolase

Enzyme catalyzing reversibly the hydrolysis of palmitoyl-CoA or other long-chain acyl coenzyme A compounds to yield CoA and palmitate or other acyl esters. The enzyme is involved in the esterification of fatty acids to form triglycerides. EC 3.1.2.2.


An edible species of the family Ranidae, occurring in Europe and used extensively in biomedical research. Commonly referred to as "edible frog".


A cytochrome form of lactate dehydrogenase found in the MITOCHONDRIA. It catalyzes the oxidation of L-lactate to PYRUVATE with transfer of electrons to CYTOCHROME C. The enzyme utilizes FMN and PROTOHEME IX as cofactors.


Monocytes, Activated Killer
Activated Killer Monocytes
Killer Monocytes, Activated

Monocytes made cytotoxic by IN VITRO incubation with CYTOKINES, especially INTERFERON-GAMMA. The cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.


Retinal Pigments
Retinal Photoreceptor Pigments
Visual Pigments

Photosensitive protein complexes of varied light absorption properties which are expressed in the PHOTORECEPTOR CELLS. They are OPSINS conjugated with VITAMIN A-based chromophores. Chromophores capture photons of light, leading to the activation of opsins and a biochemical cascade that ultimately excites the photoreceptor cells.


Chromobindin 9
Lipocortin I
Annexin I
Renocortin
Calpactin II
Lipocortin 1
Annexin A1

Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.


Receptor, Parathyroid Hormone-Like Peptide

Parathyroid Hormone-Like Peptide Receptor

Parathyroid Hormone-Related Peptide Receptor

A parathyroid hormone receptor subtype that recognizes both PARATHYROID HORMONE and PARATHYROID HORMONE-RELATED PROTEIN. It is a G-protein-coupled receptor that is expressed at high levels in BONE and in KIDNEY.


Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine (see ACETYLGLUCOSAMINE) or N-acetylgalactosamine (see ACETYLGALACTOSAMINE).


A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)


Mitochondrial Brown Fat Uncoupling Protein 1

Uncoupling Protein, Mitochondrial Membrane

A mitochondrial uncoupling protein that is expressed in BROWN ADIPOSE TISSUE. It is critical for NONSHIVERING THERMOGENESIS to prevent heat loss in NEONATES.


Peripartum Women
Peripartum
Peripartum Period

The period shortly before, during, and immediately after giving birth.


Glutathione Protein Disulfide Oxidoreductase

Protein Disulfide Reductase (Glutathione)

An enzyme that catalyzes the reduction of a protein-disulfide in the presence of glutathione, forming a protein-dithiol. Insulin is one of its substrates. EC 1.8.4.2.


A procedure to surgically correct REFRACTIVE ERRORS by cutting radial slits into the CORNEA to change its refractive properties.


Isoprenoid Phosphate Monosaccharides
Polyisoprenyl Phosphate Monosaccharides

These compounds function as activated monosaccharide carriers in the biosynthesis of glycoproteins and oligosaccharide phospholipids. Obtained from a nucleoside diphosphate sugar and a polyisoprenyl phosphate.


Regulation, Gene Expression, Archaeal
Regulation of Gene Expression, Archaeal
Archaeal Gene Expression Regulation
Gene Expression Regulation, Archaeal

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in archaea.


Contact Lens
Contact Lenses
Lenses, Contact

Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)


Eventration of Diaphragm
Diaphragmatic Eventration

A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.


Aleutian Mink Disease
Aleutian Disease of Mink

A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible.


FAPY-DNA Glycosylase
DNA-Formamidopyrimidine Glycosylase
Formamidopyrimidine-DNA Glycosylase

A DNA repair enzyme that is an N-glycosyl hydrolase with specificity for DNA-containing ring-opened N(7)-methylguanine residues.


A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.


Canker Sore
Periadenitis Mucosa Necrotica Recurrens
Aphthae
Ulcer, Aphthous
Stomatitis, Aphthous

A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)


Tachycardia, Sinoatrial Nodal Reentry
Sinus Node Reentrant Tachycardia
Tachycardia, SA Nodal Reentrant
Sinoatrial Nodal Reentry Tachycardia

Abnormally rapid heartbeats caused by reentry circuit in or around the SINOATRIAL NODE. It is characterized by sudden onset and offset episodes of tachycardia with a HEART RATE of 100-150 beats per minute. The P wave is identical to the sinus P wave but with a longer PR interval.


Adenosine Phosphates
Adenine Nucleotides


Endoscopes for examining the interior of the uterus.


Normal Distribution
Gaussian Distribution

Continuous frequency distribution of infinite range. Its properties are as follows: 1, continuous, symmetrical distribution with both tails extending to infinity; 2, arithmetic mean, mode, and median identical; and 3, shape completely determined by the mean and standard deviation.


Infections, Enterovirus
Enterovirus Infections


Salmonella choleraesuis subsp. arizonae
Salmonella enterica serovar arizonae
Arizona Bacteria
Salmonella arizonae

Gram-negative rods widely distributed in LIZARDS and SNAKES, and implicated in enteric, bone (BONE DISEASES), and joint infections (JOINT DISEASES) in humans.


Immunodeficiency, Common Variable
Common Variable Hypogammaglobulinemia
Common Variable Immunodeficiency
Common Variable Immune Deficiency
Immunoglobulin Deficiency, Late-Onset
Hypogammaglobulinemia, Acquired

Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.


Thiabendazole Omnizole Thibendole Mintesol 2-(4'-Thiazolyl)Benzimidazole Mintezol Tiabendazol

2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)


Mycobacterium chelonae chelonae
Mycobacterium chelonei
Mycobacterium chelonae

A species of gram-positive, aerobic bacteria commonly found in soil and occasionally isolated from sputum. It causes postoperative wound infections as well as gluteal abscesses.


Activated Coagulation Time, Whole Blood
Coagulation Time, Whole Blood
Whole Blood Coagulation Time
Blood Coagulation Time, Whole

The time required by whole blood to produce a visible clot.


Response Elements, Serum
Response Element, Serum
Serum Response Elements
Serum Response Element

A DNA sequence that is found in the promoter region of many growth-related genes. The regulatory transcription factor SERUM RESPONSE FACTOR binds to and regulates the activity of genes containing this element.


Meulengracht Syndrome
Unconjugated Benign Bilirubinemia
Hyperbilirubinemia 1
Gilbert's Disease
Gilbert's Syndrome
Gilbert Disease
Gilbert-Lereboullet Syndrome
Familial Nonhemolytic Jaundice
Gilbert Syndrome
Hyperbilirubinemia, Arias Type
Constitutional Liver Dysfunction
Hyperbilirubinemia I

A benign familial disorder, transmitted as an autosomal dominant trait. It is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level.


Direct In Situ Copy PCR
Primed In Situ Labeling
PRINS
DISC-PCR
In Situ Labeling, Primed

A technique that labels specific sequences in whole chromosomes by in situ DNA chain elongation or PCR (polymerase chain reaction).


Methonium Compounds
Bis-Trimethylammonium Compounds
Bis-Trimethyl-Ammonium Compounds

Compounds containing polymethylene bis-trimethylammonium cations. Members of this group frequently act as ganglionic blockers and neuromuscular depolarizing agents.


Education of Mentally Retarded
Education of Intellectually Disabled
Education, Mentally Retarded
Education of Mentally Defective
Mentally Retarded Education

The teaching or training of those individuals with subnormal intellectual functioning.


Mastocytosis, Diffuse Cutaneous
Mastocytosis, Cutaneous
Mastocytosis, Bullous
Cutaneous Mastocytosis
Skin Mastocytosis

A form of cutaneous mastocytosis that is characterized by a diffuse erythrodermic rash rather than the maculopapular infiltrates seen in URTICARIA PIGMENTOSA.


C.I. 42555
Methylrosaniline Chloride
Vigencial
Gentiaanviolet FNA
Methyl Violet
Hexamethylpararosaniline Chloride
Kristallviolett-Lösung
Gentian Violet
Crystal Violet

A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.


Generalization of Expertise
Professional Competence
Technical Expertise
Competence, Professional

The capability to perform the duties of one's profession generally, or to perform a particular professional task, with skill of an acceptable quality.


Involuntary Euthanasia
Euthanasia, Involuntary

The act or practice of killing or withholding life-sustaining treatment from a person with a medical condition, especially DISABLED PERSONS, without INFORMED CONSENT, despite the MENTAL COMPETENCY of the person to give consent.


1,2-Ethanedicarboxylic Acid
Ammonium Succinate
Succinate
Succinic Acid
Butanedioic Acid
1,4-Butanedioic Acid
Potassium Succinate

A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)


Goltz-Gorlin Syndrome
Goltz's Syndrome
Goltz Gorlin Syndrome
Goltz Syndrome
Dermal Hypoplasia, Focal
Focal Dermal Hypoplasia

A genetic skin disease characterized by hypoplasia of the dermis, herniations of fat, and hand anomalies. It is found exclusively in females and transmitted as an X-linked dominant trait.


Pattern Recognition Receptors
Receptors, Pattern Recognition

A large family of cell surface receptors that bind conserved molecular structures (PAMPS) present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens.


Puccoon Lithospermum Lithospermi Gromwell

A plant genus of the family BORAGINACEAE. Members contain lithospermans and lithospermic acid.


An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.


Signal Transducer and Activator of Transcription 1

A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.


Neuroendocrine Chaperone 7B2
Secretory Granule Protein 7B2
Neuroendocrine Peptide 7B2
Pituitary Protein 7B2
Secretory Granule Endocrine Protein I
Secretogranin V
Neuroendocrine Protein 7B2
Neuroendocrine Secretory Protein 7B2

An acidic protein found in the NEUROENDOCRINE SYSTEM that functions as a molecular chaperone for PROPROTEIN CONVERTASE 2.


Familial Adenomatous Polyposis of the Colon

A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.


Methyl CpG Binding Domain
Methyl CpG DNA Binding Domain

A protein domain of about 70 amino acids in length that folds into a sandwich structure consisting of a beta sheet, alpha helix, and C-terminal hairpin loop which forms a hydrophobic methylated-DNA binding patch. It binds to methylated CPG ISLANDS in eukaryotes and occurs with other DNA and CHROMATIN binding domains such as AT-HOOK MOTIFS in eukaryotic DNA BINDING PROTEINS.


A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.


Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.


Hormone-Dependent Neoplasms
Neoplasms, Hormone-Dependent

Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.


Fraccing
Hydraulic Fracturing
Fracking
Hydrofracturing
Hydrofracking
Hydraulic Fracking

A drilling technology in which NATURAL GAS is extracted from large deposits of impermeable rock formations known as shale, deep within the earth’s crust. This drilling technique involves injecting large volumes of high-pressure fracturing fluid (a mixture of water, sand, and chemicals) several thousand feet underground, thereby creating cracks or fissures in the shale formation, and releasing trapped gas.


Endospore Forming Bacteria
Endospore-Forming Bacteria

A group of rods or cocci whose taxonomic affinities are uncertain. They form endospores, thick-walled bodies formed within the vegetative cells of certain bacteria, able to withstand adverse environmental conditions for prolonged periods.


A beta-carboline alkaloid isolated from seeds of PEGANUM.


D-Alanine Aminotransferase
D-Glutamate-D-Alanine Transaminase
D-Alanine Transaminase

A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transfer of an amino group between D-Alanine and alpha-ketoglutarate to form PYRUVATE and D-GLUTAMATE, respectively. It plays a role in the synthesis of the bacterial CELL WALL. This enzyme was formerly classified as EC 2.6.1.10.


Human papillomavirus 11
Human papillomavirus type 11
HPV-11

A type of ALPHAPAPILLOMAVIRUS causing recurrent respiratory PAPILLOMATOSIS; GENITAL WARTS; and other neoplasms.


Audiovisual Aids
Visual Aids
Audio-Visual Aids

Auditory and visual instructional materials.


A hapten that generates suppressor cells capable of down-regulating the efferent phase of trinitrophenol-specific contact hypersensitivity. (Arthritis Rheum 1991 Feb;34(2):180).


A genus of flowering plants in the family PRIMULACEAE, found worldwide but primarily in tropical and subtropical regions.


S6-H4 Kinase
S6 Kinase
Ribosomal Protein S6 Kinase
Ribosomal Protein S6 Kinases

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.


DNA Cruciforms
Holliday Junctions
Holliday Junction DNA
DNA, Cruciform
Cruciform DNA

A cross-shaped DNA structure that can be observed under the electron microscope. It is formed by the incomplete exchange of strands between two double-stranded helices or by complementary INVERTED REPEAT SEQUENCES that refold into hairpin loops on opposite strands across from each other.


A plant genus of the family LAMIACEAE having characteristic flavor.


Prolyl 4-Hydroxylase
Prolyl Hydroxylase
Prolyl Hydroxylases
Proline Hydroxylase
Peptidyl Prolyl Hydroxylase
Proline,2-Oxoglutarate 4-Dioxygenase

Enzymes that specifically hydroxylate PROLINE residues on proteins.


Antibody, Catalytic
Antibodies, Catalytic
Catalytic Antibodies

Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.


Elder, Black
Black Elder
Elder, European
Sambucus nigra
Black Elderberry

A plant species in the genus SAMBUCUS, known for the elderberry fruit. The plant is also a source of Sambucus nigra lectins and ribosome-inactivating protein.


Familial Infantile Cortical Hyperostosis

A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)


Apstil
Stilbene Estrogen
Diethylstilbestrol
Diethylstilbestrol, (Z)-Isomer
Diethylstilbestrol, Disodium Salt
Distilbène
Agostilben
Tampovagan
Stilbestrol

A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)


Respirator Weaning
Ventilator Weaning
Mechanical Ventilator Weaning

Techniques for effecting the transition of the respiratory-failure patient from mechanical ventilation to spontaneous ventilation, while meeting the criteria that tidal volume be above a given threshold (greater than 5 ml/kg), respiratory frequency be below a given count (less than 30 breaths/min), and oxygen partial pressure be above a given threshold (PaO2 greater than 50mm Hg). Weaning studies focus on finding methods to monitor and predict the outcome of mechanical ventilator weaning as well as finding ventilatory support techniques which will facilitate successful weaning. Present methods include intermittent mandatory ventilation, intermittent positive pressure ventilation, and mandatory minute volume ventilation.


Ligand-Gated Ion Channels
Ligand-Gated Channels

A subclass of ion channels that open or close in response to the binding of specific LIGANDS.


Immunoglobulin J Recombination Signal Sequence-Binding Protein

Ig J Recombination Signal Sequence Binding Protein

A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS.


Oncology Nursing
Cancer Nursing
Oncological Nursing
Oncologic Nursing
Nursing, Oncologic

A nursing specialty concerned with the care provided to cancer patients. It includes aspects of family functioning through education of both patient and family.


Myeloablative Agonist
Myeloablative Agonists

Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.


Angina Pectoris, Stable
Angina, Stable
Chronic Stable Angina

Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.


Confusion, Post-Ictal
Confusion
Confusional State
Disorientation
Bewilderment
Confusion, Reactive

A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.


Herpes Simplex, Oral
Stomatitis, Herpetic
Gingivostomatitis, Herpetic

Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.


Urinary Tract Stones
Urinary Stones
Urinary Calculi

Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.


Corneal Thickness Measurement
Corneal Pachymetric Measurement
Corneal Pachymetry

Measurement of the thickness of the CORNEA.


Heart Rate Determination
Pulse Rate Determination

Methods, techniques, and processes by which HEART RATE is measured.


Circulating Tumor DNA
Cell-Free Tumor DNA

DNA released from tumor cells that is found circulating in PLASMA; SERUM; or other BODY FLUIDS.


Radio Waves
Short Waves
Very High Frequency Waves
Hertzian Waves
High Frequency Waves

Electromagnetic waves with frequencies between about 3 kilohertz (very low frequency - VLF) and 300,000 megahertz (extremely high frequency - EHF). They are used in television and radio broadcasting, land and satellite communications systems, radionavigation, radiolocation, and DIATHERMY. The highest frequency radio waves are MICROWAVES.


Positron Emission Tomography Computed Tomography

Positron Emission Tomography-Computed Tomography

An imaging technique that combines a POSITRON-EMISSION TOMOGRAPHY (PET) scanner and a CT X RAY scanner. This establishes a precise anatomic localization in the same session.


46,XX DSD
46, XX Disorders of Sex Development
Female Pseudohermaphroditism
46, XX DSD
46,XX Disorders of Sex Development

Congenital conditions in individuals with a female karyotype, in which the development of the gonadal or anatomical sex is atypical.


The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.


Wedge Pressures, Pulmonary
Wedge Pressure, Pulmonary
Pulmonary Venous Wedge Pressure
Pulmonary Wedge Pressure
Wedge Pressure
Pressures, Pulmonary Wedge
Pulmonary Capillary Wedge Pressure
Pulmonary Wedge Pressures
Pulmonary Artery Wedge Pressure
Pressure, Pulmonary Wedge

The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.


Trp-tRNA Ligase
Tryptophanyl-tRNA Synthetase
Tryptophan-tRNA Ligase
Tryptophanyl T RNA Synthetase

An enzyme that activates tryptophan with its specific transfer RNA. EC 6.1.1.2.


Twinning, Monozygotic
Monozygotic Twinning
Monozygous Twinning

The division of a ZYGOTE into two parts that are each capable of further development into two distinct individuals, both that have the same genetic makeup.


LAMPA Protein
CD107a Antigen
CD107a Antigens
Lysosomal-Associated Membrane Protein 1
Antigens, CD107a
LGP120 Protein
LAMP1 Protein

An abundant lysosomal-associated membrane protein that has been found to shuttle between LYSOSOMES; ENDOSOMES; and the PLASMA MEMBRANE. In PLATELETS and T-LYMPHOCYTES it may play a role in the cellular degranulation process.


An endocellulase with specificity for the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans including laminarin, paramylon, and pachyman.


A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)


One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla.


A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)


Myosins, Cardiac
Cardiac Myosins
Cardiac Myosin
Cardiac Muscle Myosins

Myosin type II isoforms found in cardiac muscle.


The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.


Poly(A)-Binding Protein I
Poly(A)-Binding Protein, Cytoplasmic 1
p70 Poly(A) Binding Protein
PAB1 Poly(A) Binding Protein
PABPC1 Protein
PABP1 Protein

A poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles.


Plant Preparation
Plant Preparations
Herbal Preparation
Herbal Preparations


IRF-2 Transcription Factor
HINF-M Transcription Factor
Histone Nuclear Factor M
Interferon Regulatory Factor-2

An interferon regulatory factor that represses transcription of TYPE I INTERFERONS and activates transcription of HISTONE H4.


Fluorocarbon Aerosols
Chlorofluoromethanes
Fluorocarbon Propellants
Chlorofluorocarbons, Methane

A group of methane-based halogenated hydrocarbons containing one or more fluorine and chlorine atoms.


Virus Budding
Virus Egress
Virus Release

Release of a virus from the host cell following VIRUS ASSEMBLY and maturation. Egress can occur by host cell lysis, EXOCYTOSIS, or budding through the plasma membrane.


DNA Damage-Inducible Transcript 3 Protein

Growth Arrest And DNA Damage-Inducible Protein 153

A CCAAT-enhancer binding protein that is induced by DNA DAMAGE and growth arrest. It serves as a dominant negative inhibitor of other CCAAT-enhancer binding proteins.


DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. "pol" is short for polymerase, the enzyme class of reverse transcriptase.


Woringer-Kolopp Disease
Woringer Kolopp Disease
Pagetoid Reticulosis
Ketron-Goodman Disease

A generalized or disseminated form of pagetoid reticulosis. Some authors consider it to be a primary cutaneous aggressive epidermotrophic CD8+ T-Cell lymphoma.


Regulators of G-Protein Signaling Proteins

A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.


The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. (From Merck Index, 11th ed)


Bones of Toes
Toe Phalanges
Toe Bones
Phalanges of Toes

Bones that make up the SKELETON of the TOES, consisting of two for the great toe, and three for each of the other toes.


Education of the individual who markedly deviates intellectually, physically, socially, or emotionally from those considered to be normal, thus requiring special instruction.


A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.


Polytrauma
Multiple Trauma
Trauma, Multiple
Multiple Injuries
Injuries, Multiple
Wounds, Multiple

Multiple physical insults or injuries occurring simultaneously.


A synthetic progestational hormone used in veterinary practice as an estrus regulator.


Otorhinolaryngological Neoplasms
Neoplasms, Otorhinolaryngological
Otorhinolaryngeal Cancer
Neoplasms, Otorhinolaryngologic
Otorhinolaryngologic Neoplasm
Ootorhinolaryngeal Neoplasms
Otorhinolaryngologic Neoplasms

A general concept for tumors or cancer of any part of the EAR; the NOSE; the THROAT; and the PHARYNX. It is used when there is no specific heading.


TATA-Box-Binding Protein
RNA Polymerase II TATA-Binding Protein
TATA-Box Binding Protein
TATA-Binding Protein
Transcription Factor TBP

A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.


Over-the-Counter Drugs
Drugs, Nonprescription
Patent Medicines
Nonprescription Drugs
Medicines, Patent
Non-Prescription Drugs
OTC Drugs
Drugs, Non-Prescription

Medicines that can be sold legally without a DRUG PRESCRIPTION.


Sapporo-like Viruses
Sapovirus
Sapporo virus

A genus of the family CALICIVIRIDAE associated with worldwide sporadic outbreaks of GASTROENTERITIS in humans. The first recorded outbreak was in human infants in Sapporo, Japan in 1977. The genus is comprised of a single species, Sapporo virus, containing multiple strains.


A rare aberrant human behavior involving consumption of excrement.


Muriatic Acid
Hydrogen Chloride
Hydrochloric Acid

A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.


Notch-4 Protein
Notch4 Receptor
Notch4 Protein
Notch-4 Receptor
Receptor, Notch4

A notch receptor and proto-oncogene protein characterized by a large extracellular domain that consists of 29 EPIDERMAL GROWTH FACTOR  - like repeat sequences (EGF repeats) and five ANKYRIN REPEATS. It functions as a receptor for SERRATE-JAGGED PROTEINS and Delta1 (DLK1) protein to control cell fate determination.


Spinal Osteophytosis
Osteophytosis, Spinal

Outgrowth of immature bony processes or bone spurs (OSTEOPHYTE) from the VERTEBRAE, reflecting the presence of degenerative disease and calcification. It commonly occurs in cervical and lumbar SPONDYLOSIS.


Aryl Hydrocarbon Receptor Nuclear Translocator

Hypoxia-Inducible Factor 1, beta Subunit

Ah Receptor Nuclear Translocator Protein

Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.


A genus of flagellate intestinal EUKARYOTES parasitic in various vertebrates, including humans. Characteristics include the presence of four pairs of flagella arising from a complicated system of axonemes and cysts that are ellipsoidal to ovoidal in shape.


Starch Phosphorylase b
Starch Phosphorylase
Amylophosphorylase
Starch Phosphorylase a

An enzyme of the PHOSPHORYLASES family that catalyzes the degradation of starch, a mixture of unbranched AMYLOSE and branched AMYLOPECTIN compounds. This phosphorylase from plants is the counterpart of GLYCOGEN PHOSPHORYLASE in animals that catalyzes the reaction of inorganic phosphate on the terminal alpha-1,4-glycosidic bond at the non-reducing end of glucans resulting in the release of glucose-1-phosphate.


Transportation of Patients
Transport of Wounded and Sick
Transport, Wounded and Sick

Conveying ill or injured individuals from one place to another.


Activation Analysis, Neutron
Neutron Activation Analysis
Analysis, Neutron Activation

Activation analysis in which the specimen is bombarded with neutrons. Identification is made by measuring the resulting radioisotopes. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.


Phonological Disorder
Speech Sound Disorder

Persistent difficulty with speech sound production such that it interferes with verbal communication.


Hypersensitivity, Atopic
Type I Hypersensitivity
Hypersensitivity, Immediate
Atopic Hypersensitivity
IgE-Mediated Hypersensitivity
Hypersensitivity, Type I

Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.


5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.


Anaphase-Promoting Complex-Cyclosome
Anaphase Promoting Complex

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.


N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant growth regulators.


Psychology, Clinical
Clinical Psychology

The branch of psychology concerned with psychological methods of recognizing and treating behavior disorders.


Angiotensin II Type 2 Receptor Antagonists

Agents that antagonize the ANGIOTENSIN II TYPE 2 RECEPTOR.


A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.


Complement C3-C5 Convertases, Classical Pathway

Important enzymes in the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. They cleave COMPLEMENT C3 and COMPLEMENT C5.


Geobacillus stearothermophilus
Bacillus stearothermophilus

A species of GRAM-POSITIVE ENDOSPORE-FORMING BACTERIA in the family BACILLACEAE, found in soil, hot springs, Arctic waters, ocean sediments, and spoiled food products.


Amyloid beta-Peptide
Alzheimer's Amyloid Fibril Protein
beta-Amyloid Protein
Amyloid Fibril Protein, Alzheimer's
Amyloid beta-Protein
Amyloid beta-Proteins
Alzheimer beta-Protein
Amyloid AD-AP
Amyloid Protein A4
Alzheimer's ABP
Amyloid beta-Peptides

Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.


Loose Anagen Hair Syndrome
Loose Anagen Syndrome

Benign childhood alopecia that improves spontaneously with aging. It is characterized by anagen hairs (misshapen hair bulbs and absent inner and outer root sheaths), thin, and sparse hairs that pulls out easily.


A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.


Anesthesia, Caudal
Anesthesia, Sacral Epidural

Epidural anesthesia administered via the sacral canal.


Proteases which use a metal, normally ZINC, in the catalytic mechanism. This group of enzymes is inactivated by metal CHELATORS.


Parilla, Yellow
Menispermum cocculus
Menispermum
Yellow Parilla
Menispermum canadense
Moonseed
Menispermum dauricum

A plant genus of the family MENISPERMACEAE. Members contain dauricine and other ALKALOIDS.


Swine Infertility Respiratory Syndrome Virus

Porcine Reproductive and Respiratory Syndrome Virus

Porcine respiratory and reproductive syndrome virus

Swine Infertility and Respiratory Syndrome Virus

A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. Airborne transmission is common.


Shiga Toxins
Vero Toxin
Vero Toxins
Vero Cell Cytotoxins
Shiga-Like Toxins
Vero Cytoxins
Vero Cytotoxin
Verotoxin
Verotoxins
Vero Cell Cytotoxin

A class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA, RIBOSOMAL) with PEPTIDE ELONGATION FACTORS. They include SHIGA TOXIN which is produced by SHIGELLA DYSENTERIAE and a variety of shiga-like toxins that are produced by pathologic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157.


Protein C Inhibitor
PAI-3
Activated Protein C Inhibitor
Type 3 Plasminogen Activator Inhibitor
Protein C Inhibitor, Activated
Plasminogen Activator Inhibitor, Type 3
Plasminogen Activator Inhibitor 3
Serpin A5

A member of the serpin family of proteins that is found in plasma and urine. It is dependent on heparin and is able to inhibit activated PROTEIN C; THROMBIN; KALLIKREIN; and other SERINE ENDOPEPTIDASES.


Atrioventricular Nodal Reentrant Tachycardia

Tachycardia, Atrioventricular Nodal Reentry

Atrioventricular Nodal Reentry Tachycardia

Abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE. The common type involves a blocked atrial impulse in the slow pathway which reenters the fast pathway in a retrograde direction and simultaneously conducts to the atria and the ventricles leading to rapid HEART RATE of 150-250 beats per minute.


The region of the thorax that includes the PLEURAL CAVITY and MEDIASTINUM.


The smallest species of TAPEWORMS. It is the only cestode that parasitizes humans without requiring an intermediate host.


Salmonella enterica serovar Paratyphi B
Salmonella schottmuelleri
Salmonella paratyphi B

A serotype of SALMONELLA ENTERICA which is an agent of PARATYPHOID FEVER in humans.


One of a set of bone-like structures in the mouth used for biting and chewing.


A plant genus of the family RANUNCULACEAE. The name is similar to giant fennel (FERULA), true fennel (FOENICULUM), and dog fennel (ANTHEMIS).


Ventromedial Hypothalamic Nucleus
Hypothalamic Nucleus, Ventromedial

A nucleus of the middle hypothalamus, the largest cell group of the tuberal region with small-to-medium size cells.


Structure, Molecular
Molecular Structure

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.


United States Prospective Payment Assessment Commission

The commission charged with evaluating issues and factors which affect the implementation of the PROSPECTIVE PAYMENT SYSTEM.


Capreomycin Sulfate
Capromycin
Capastat
Capreomycin

Cyclic peptide antibiotic similar to VIOMYCIN. It is produced by Streptomyces capreolus.


Ventriculoperitoneal Shunt
Ventriculo-peritoneal Shunt

Surgical creation of a communication between a cerebral ventricle and the peritoneum by means of a plastic tube to permit drainage of cerebrospinal fluid for relief of hydrocephalus. (From Dorland, 28th ed)


Immediate-Early Proteins
Proteins, Immediate-Early

Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.


A plant genus of the family RUBIACEAE. Members contain genepin, from which geniposide is obtained for use as a crosslinking agent in ADHESIVES, and 3-caffeoyl-4-sinapoylquinic acid.


Receptors, Pituitary Adenylate Cyclase-Activating Peptide, Type II

Receptors, Vasoactive Intestinal Polypeptide, Type I

Vasoactive Intestinal Peptide 1 Receptor

Vasoactive Intestinal Peptide Receptors, Type I

Pituitary Adenylate Cyclase-Activating Peptide Receptor Type II

Vasoactive Intestinal Peptide Receptor 1

A pituitary adenylate cyclase-activating polypeptide receptor subtype that binds both PACAP and VASOACTIVE INTESTINAL PEPTIDE. It is found predominately in the BRAIN.


The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).


Fibrinogen Receptors
Receptors, Fibrinogen

Receptors that bind FIBRINOGEN through distinct adhesive sequences on the fibrinogen molecule. Although MACROPHAGE-1 ANTIGEN is considered an important signaling molecule for fibrinogen interaction, a variety of INTEGRINS from all three major families, (beta1, beta2, and beta3) have been shown to bind fibrinogen.


Reflex, Startle
Startle Reaction
Reflex, Moro
Acoustic Startle Reflex
Startle Response

A reflex found in normal infants, observed when the infant is startled or feels the sensation of falling and characterized by sudden extension of the arms. It is only seen in children and adults suffering from disorders of the CENTRAL NERVOUS SYSTEM, and is distinct from the startle reflex found in normal children and adults.


A philosophical description of intrinsic self-worth and dignity which bestows basic rights of life, liberty, and freedom from harm.


Particle Interactions, Elementary
Elementary Particle Interactions

The interactions of particles responsible for their scattering and transformations (decays and reactions). Because of interactions, an isolated particle may decay into other particles. Two particles passing near each other may transform, perhaps into the same particles but with changed momenta (elastic scattering) or into other particles (inelastic scattering). Interactions fall into three groups: strong, electromagnetic, and weak. (From McGraw-Hill Encyclopedia of Science & Technology, 7th ed)


A species of DELTARETROVIRUS that includes the strains SIMIAN T-LYMPHOTROPIC VIRUS 3 and HUMAN T-LYMPHOTROPIC VIRUS 3.


N,N-Dimethyl-5-hydroxytryptamine Bufotenine Dimethylserotonin Bufotenin Mappin 5-Hydroxy-N,N-dimethyltryptamine Mappine

A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a tool in CNS studies and misused as a psychedelic.


Cholesterol Ester Lysolecithin Acyltransferase

An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.


HPbetaCD
2-Hydroxypropyl-beta-cyclodextrin
Hydroxypropyl-beta-cyclodextrin
beta-Hydroxypropylcyclodextrin
HP-beta-CD
Hydroxypropyl Betadex
2 Hydroxypropyl-beta-cyclodextrin

Derivative of beta-cyclodextrin that is used as an excipient for steroid drugs and as a lipid chelator.


Discoidin Domain Receptor Family, Member 2 Protein

Discoidin Domain Receptor Tyrosine Kinase 2

Neurotrophic Tyrosine Kinase, Receptor-Related 3 Protein

A discoidin domain receptor for FIBRILLAR COLLAGEN and non-fibrillar COLLAGEN TYPE X. It functions in many cellular and developmental processes that include remodeling of the EXTRACELLULAR MATRIX; CELL MIGRATION; CELL DIFFERENTIATION; and CELL PROLIFERATION; as well as OSTEOGENESIS and the maturation of CHONDROCYTES.


Covering for the hands usually with separation for the fingers, made of various materials for protection against infections, toxic substances, extremes of hot and cold, radiation, water immersion, etc. Protective gloves may be worn by patients, care givers, laboratory personnel, industrial workers, and police, among others.


Infections, Treponemal
Bejel
Treponemal Infections

Infections with bacteria of the genus TREPONEMA.


Quipazine Maleate (1:1)
Quipazine Hydrochloride
MA-1291
2-(1-Piperazinyl)quinoline
Quipazine
Quipazine Maleate

A pharmacologic congener of serotonin that contracts smooth muscle and has actions similar to those of tricyclic antidepressants. It has been proposed as an oxytocic.


Activities by crew members conducted outside the pressurized hull of a spacecraft.


Patient Medication Knowledge
Patient Drug Knowledge

Patient health knowledge related to medications including what is being used and why as well as instructions and precautions.


Proteins that are preferentially expressed or upregulated during FETAL DEVELOPMENT.


Pre-Exposure Prophylaxis
Pre-Exposure Prophylaxis (PrEP)

A method of disease prevention (abbreviated PrEP) which involves the administration of drugs to at-risk persons who have not been exposed to the disease-causing agent.


Hepatitis A Virus Antigens
Hepatitis A Antigens

Antigens produced by various strains of HEPATITIS A VIRUS such as the human hepatitis A virus (HEPATITIS A VIRUS, HUMAN).


1,3-Bis(2-Chloroethyl)-1-Nitrosourea N,N'-Bis(2-Chloroethyl)-N-Nitrosourea Nitrumon FIVB BiCNU Carmustine BCNU

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)


Fatty Acyl-CoA - Sphingosine Acyltransferase

An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.


Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.


Bursa-Dependent Lymphocytes
B-Lymphocytes
B-Cells

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.


Obstetric Surgical Procedures
Surgical Procedure, Obstetric
Surgery, Obstetric
Procedure, Obstetric Surgical
Procedures, Obstetric Surgical
Obstetrical Surgery
Obstetric Surgical Procedure
Obstetrical Surgical Procedures
Surgical Procedures, Obstetric

Surgery performed on the pregnant woman for conditions associated with pregnancy, labor, or the puerperium. It does not include surgery of the newborn infant.


Psychiatric Somatic Therapies
Psychiatric Somatic Therapy
Somatic Therapies, Psychiatric
Therapies, Psychiatric Somatic

The biologic treatment of mental disorders (e.g., ELECTROCONVULSIVE THERAPY), in contrast with psychotherapy. (Stone, American Psychiatric Glossary, 1988, p159)


Receptors, Ectodysplasin
Ectodysplasin Receptors
Ectodysplasin A Receptor
Ectodysplasin Receptor

Members of the TNF receptor family that are specific for ECTODYSPLASIN. At least two subtypes of the ectodysplasin receptor exist, each being specific for a ectodysplasin isoform. Signaling through ectodysplasin receptors plays an essential role in the normal ectodermal development. Genetic defects that result in loss of ectodysplasin receptor function results ECTODERMAL DYSPLASIA.


Nephroma, Mesoblastic
Congenital Mesoblastic Nephroma
Mesoblastic Nephroma

A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.


Technology, Radiologic
Radiologic Technology
Technology, Radiological

The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.


Dibenzylchlorethamine
Dibenzyl Chlorethylamine
Dibenamine


A plant genus of the family Amaryllidaceae. Members contain ungiminorine and LECTINS.


Scorpion Venoms
gamma-Scorpion Toxin
alpha-Scorpion Toxin
beta-Scorpion Toxin
Scorpion Venom

Venoms from animals of the order Scorpionida of the class Arachnida. They contain neuro- and hemotoxins, enzymes, and various other factors that may release acetylcholine and catecholamines from nerve endings. Of the several protein toxins that have been characterized, most are immunogenic.


Protein-Restricted Diet
Low-Protein Diet
Diet, Protein-Free
Diet, Low-Protein
Diet, Protein-Restricted

A diet that contains limited amounts of protein. It is prescribed in some cases to slow the progression of renal failure. (From Segen, Dictionary of Modern Medicine, 1992)


Carbonic Anhydrase Isozyme IV
Carbonic Anhydrase 4
Carbonic Anhydrase IV

A membrane-bound carbonic anhydrase found in lung capillaries and kidney.


Pathological processes involving the STOMACH.


Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.


CRF-41
ACTH-Releasing Hormone
CRF (ACTH)
ACTH-Releasing Factor
Corticotropin-Releasing Factor-41
Corticotropin-Releasing Hormone-41
Corticotropin-Releasing Factor
Corticoliberin
Corticotropin-Releasing Hormone

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.


Plasmacytic Leukemia
Plasma Cell Leukemia
Leukemia, Plasma Cell
Leukemia, Plasmacytic

A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.


The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.


Postneonatal Mortality
Mortality, Infant
Infant Mortality
Neonatal Mortality

Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.


Vascular Nursing
Cardiovascular Nursing
Cardiac Care Nursing
Cardiac Vascular Nursing
Cardiac Nursing
Coronary Care Nursing

Nursing specialty concerning patients with disorders of the BLOOD VESSELS or vascular system.


Mixed-Lineage Leukemia Protein
Acute Lymphoblastic Leukemia Protein 1
Proto-Oncogene Proteins MLL
MLL Proto-Oncogene Protein
Myeloid-Lymphoid Leukemia Protein
Zinc Finger Protein HRX

Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS.


Herpesvirus 2, Human
Human Herpesvirus 2
HHV-2
Herpes Simplex Virus Type 2
Herpes Simplex Virus 2
HSV-2
Herpesvirus 2 (alpha), Human

A species of SIMPLEXVIRUS associated with genital infections (HERPES GENITALIS). It is transmitted by sexual intercourse and close personal contact.


Folic Acid Transporters
Folate Transporters
Folate Transport Proteins
Folic Acid Transport Proteins

Proteins involved in the transport of FOLIC ACID and folate derivatives across the CELLULAR MEMBRANE.


Quinidine
Quincardine
Quinidex
Apo-Quinidine
Quinidine Sulfate
Adaquin
Quinora
Chinidin

An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.


Complication of CHOLELITHIASIS characterized by OBSTRUCTIVE JAUNDICE; abdominal pain, and fever.


Brucella melitensis biovar abortus
Brucella abortus

A species of the genus BRUCELLA whose natural hosts are cattle and other bovidae. Abortion and placentitis are frequently produced in the pregnant animal. Other mammals, including humans, may be infected.


Dentifrices that are formulated into a paste form. They typically contain abrasives, HUMECTANTS; DETERGENTS; FLAVORING AGENTS; and CARIOSTATIC AGENTS.


Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 1

A receptor activity-modifying protein that is a subunit of specific G-PROTEIN COUPLED RECEPTORS. The CALCITONIN GENE-RELATED PEPTIDE RECEPTOR is formed from a dimer of this protein and CALCITONIN RECEPTOR-LIKE PROTEIN, while an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.


Ichthyosis Simplex
Ichthyosis Vulgaris, Dominant
Ichthyosis Vulgaris

Most common form of ICHTHYOSIS characterized by prominent scaling especially on the exterior surfaces of the extremities. It is inherited as an autosomal dominant trait.


Triacetyl-glycerol Enzactin Triacetylglycerol Triacetin

A triglyceride that is used as an antifungal agent.


The flat, triangular bone situated at the anterior part of the KNEE.


Paraneoplastic Endocrine Syndromes
Ectopic Hormone Syndromes

Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.


The smallest and most inferior triangular protrusion of the STERNUM or breastbone that extends into the center of the RIBCAGE.


Parent-Child Relationship
Parent-Child Relations
Parent Child Relationship

The interactions between parent and child.


Retinoblastoma-Binding Protein 2
RBBP2 Protein
Jumonji, AT Rich Interactive Domain 1A
Jumonji Domain-Containing Protein 1A

A retinoblastoma binding protein that is also a member of the Jumonji-domain histone demethylases. It has demethylation activity towards specific LYSINE residues found on HISTONE H3.


Paired Box 9 Protein
Paired Box Transcription Factor 9
PAX9 Transcription Factor

A paired box transcription factor that is involved in ODONTOGENESIS.


Impaired Glucose Tolerance
Glucose Intolerance

A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.


1,4-Imino Sugars
Hydroxymethylpyrrolidines
Imino Furanoses
Hydroxy-Methyl-Pyrrolidines

Five-carbon furanose sugars in which the OXYGEN is replaced by a NITROGEN atom.


A plant genus of the family LAMIACEAE that contains cyasterone, ajugasterone, 20-hydroxyecdysone, 8-acetylharpagide (an iridoid glycoside).


A polyene polymer that consists of alternating single and double bonds.


Dental Models
Model, Dental
Models, Dental
Dental Model

Presentation devices used for patient education and technique training in dentistry.


Genes, Retinoblastoma
Retinoblastoma Genes
Genes, Rb
Rb Genes

Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.


Species of tapeworm in the genus TAENIA, that infects cattle. It is acquired by humans through the ingestion of raw or insufficiently cooked beef.


A plant genus of the family CUPRESSACEAE known for tall trees like the SEQUOIA redwoods.


Geriatric Assessment
Assessment, Geriatric

Evaluation of the level of physical, physiological, or mental functioning in the older population group.


The mental process by which an individual implicitly and explicitly interprets the actions of self and others as meaningful on the basis of intentional mental states such as personal desires, needs, feelings, beliefs, and reasons.


Trypsin Inhibitor, Bowman-Birk Soybean
Trypsin Inhibitor, Bowman Birk Soybean
Bowman-Birk Soybean Trypsin Inhibitor

A low-molecular-weight protein (minimum molecular weight 8000) which has the ability to inhibit trypsin as well as chymotrypsin at independent binding sites. It is characterized by a high cystine content and the absence of glycine.


Portoenterostomy, Hepatic
Hepatoportoenterostomy
Hepatic Portoenterostomy
Kasai Procedure

Operation for BILIARY ATRESIA by anastomosis of the BILE DUCTS into the JEJUNUM or DUODENUM.


Large spherical double-layered structures which function in AUTOPHAGY to engulf intracellular components such as ORGANELLES or pathogens. Their outer membrane then fuses with the LYSOSOME and the inner membrane and contents are digested by lysosomal HYDROLASES.


Haloarcula marismortui
Halobacterium marismortui

A species of halophilic archaea distinguished by its production of acid from sugar. This species was previously called Halobacterium marismortui.


Class II Histone Deacetylases
Histone Deacetylase
Class I Histone Deacetylases
Histone Deacetylase Complexes
Histone Deacetylases
HDAC Proteins

Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.


Effective Renal Plasma Flow
Plasma Flow, Renal, Effective
ERPF
Renal Plasma Flow, Effective

The amount of PLASMA flowing to the parts of the KIDNEY that function in the production of urine. It is the amount of plasma perfusing the KIDNEY TUBULES per unit time, generally measured by P-AMINOHIPPURATE clearance. It should be differentiated from RENAL PLASMA FLOW which is approximately 10% greater than the effective renal plasma flow.


Purinergic Receptor P2Y, G-Protein Coupled, 12

A subclass of purinergic P2Y receptors that have a preference for ADP binding and are coupled to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI. The P2Y12 purinergic receptors are found in PLATELETS where they play an important role regulating PLATELET ACTIVATION.


Tumor Royale
Neurofibroma, Plexiform
Neuromas, Plexiform
Elephantiasis Neuromatosis
Pachydermatocele

A type of neurofibroma manifesting as a diffuse overgrowth of subcutaneous tissue, usually involving the face, scalp, neck, and chest but occasionally occurring in the abdomen or pelvis. The tumors tend to progress, and may extend along nerve roots to eventually involve the spinal roots and spinal cord. This process is almost always a manifestation of NEUROFIBROMATOSIS 1. (From Adams et al., Principles of Neurology, 6th ed, p1016; J Pediatr 1997 Nov;131(5):678-82)


A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.


Vulvar Lichen Sclerosus
Kraurosis Vulvae
Lichen Sclerosus of Vulva

Atrophy and shriveling of the SKIN of the VULVA that is characterized by the whitish LICHEN SCLEROSUS appearance, inflammation, and PRURITUS.


Precursor cells destined to differentiate into skeletal myocytes (MYOCYTES, SKELETAL).


Angiopoietin-related Protein 4
ANGPTL4 Protein
Angiopoietin-like 4 Protein
Angiopoietin-like Protein 4

A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.


Neoplasms, Nervous Tissue
Nerve Tissue Neoplasms
Nervous Tissue Neoplasms
Neoplasms, Nerve Tissue

Neoplasms composed of nerve tissue. This concept does not refer to neoplasms located in the nervous system or its component nerves.


Ciona robusta
Vase Tunicate
Ciona intestinalis
Yellow Sea Squirt

Vase or tube shaped TUNICATES with a cosmopolitan distribution.


Chick syncytial virus
Avian Reticuloendotheliosis Virus Group
Reticuloendotheliosis Viruses, Avian
Avian Reticuloendotheliosis Viruses

Species of RETICULOENDOTHELIOSIS VIRUSES, AVIAN infecting chickens.


Plasma Cell Neoplasms
Neoplasms, Plasma Cell

Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.


Macrophage Colony-Stimulating Factor Receptors

Receptors, Macrophage Colony-Stimulating Factor

Receptor, Macrophage Colony-Stimulating Factor

A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.


Drug Insurance
Insurance, Pharmacy Services
Prescription Insurance
Drug Benefit Plans
Insurance, Pharmaceutical Services
Pharmaceutic Services Insurance
Pharmacy Services Insurance
Insurance, Pharmaceutic Services
Pharmaceutical Services Insurance

Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.


The design or construction of objects greatly reduced in scale.


Bonamia ostreae
Haplosporida
Haplosporidia

A species in the order HAPLOSPORIDA which is a parasite of the flat oyster, Ostrea edulis.


The sensory discrimination of a pattern shape or outline.


Colony-Stimulating Factor, Macrophage
Macrophage Colony-Stimulating Factor
CSF-M
CSF-1
Colony-Stimulating Factor 1
M-CSF

A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).


Fanconi Anemia Group L Complementing Protein

Fanconi Anemia Complementation Group L Protein

An E3 UBIQUITIN LIGASE that plays a key role in the DNA damage response pathway of FANCONI ANEMIA PROTEINS. It is associated with mono-ubiquitination of FANCD2 PROTEIN and the redistribution of FANCD2 to nuclear foci containing BRCA1 PROTEIN.


Congenital abnormality characterized by the lack of full development of the ESOPHAGUS that commonly occurs with TRACHEOESOPHAGEAL FISTULA. Symptoms include excessive SALIVATION; GAGGING; CYANOSIS; and DYSPNEA.


An order of parasitic, blood-sucking, wingless INSECTS with the common name of fleas.


Variola virus
Smallpox Virus
Poxvirus variolae

A species of ORTHOPOXVIRUS causing infections in humans. No infections have been reported since 1977 and the virus is now believed to be virtually extinct.


Chemicals, Laboratory
Laboratory Chemicals

Chemicals necessary to perform experimental and/or investigative procedures and for the preparation of drugs and other chemicals.


Duhring Disease
Duhring's Disease
Dermatitis Herpetiformis

Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.


Nidoviruses Mesoniviridae Alphamesoniviruses Mesoniviruses Nidovirales

An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are Mesoniviridae; CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.


Societies, Scientific
Scientific Societies
American Psychological Association

Societies whose membership is limited to scientists.


Methyl Viologen
Paraquat
Paragreen A
Gramoxone

A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.


The sensation of cold, heat, coolness, and warmth as detected by THERMORECEPTORS.


Congenital anomaly of abnormally short fingers or toes.


Evans Blue
C.I. 23860
C.I. Direct Blue 53
Azovan Blue
Evan's Blue

An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.


A glial cell line-derived neurotrophic factor ligand that is specific for the GFRA2 RECEPTOR. Neurturin is essential for the development of specific postganglionic parasympathetic NEURONS.


Conjunctivitis, Viral
Viral Conjunctivitis

Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.


A sulfamoylbenzamide analog of CLOPAMIDE. It is diuretic and saluretic with antihypertensive activity. It is bound to PLASMA PROTEINS, thus has a delayed onset and prolonged action.


Leukocytes
White Blood Corpuscles
Blood Corpuscles, White
Blood Cells, White
White Blood Cells

White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).


Hydrocarbons, Aromatic
Aromatic Hydrocarbons

Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.


Signal Transducing Adaptor Proteins
Adaptor Proteins, Signal Transducing

A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes


A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)


Pharmaceutical Arithmetic
Drug Dosage Calculations
Pharmaceutical Calculations

Math calculations done for preparing appropriate doses of medicines, taking into account conversions of WEIGHTS AND MEASURES. Mistakes are one of the sources of MEDICATION ERRORS.


Sulfacetamide, Monosodium Salt, Anhydrous

An anti-bacterial agent that is used topically to treat skin infections and orally for urinary tract infections.


Menkea Syndrome
X-Linked Copper Deficiency
Menkes' Disease
Kinky Hair Disease
Steely Hair Disease
Hypocupremia, Congenital
Copper Transport Disease
Congenital Hypocupremia
Menkes Kinky Hair Syndrome
Steely Hair Syndrome
Menkes Disease
Kinky Hair Syndrome
Menkes Syndrome

An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)


alpha(6) Integrin
alpha6 Integrin
Integrin alpha6
CD49f Antigen
Integrin alpha6B
CD49f Antigens
Integrin alpha6A
Antigens, CD49f

An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.


Genetic Recombination
Recombination
Recombination, Genetic

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.


Cardiovascular Agents
Cardioactive Agents
Cardiovascular Drugs
Cardioactive Drugs

Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.


Hospital Oncology Service
Service, Hospital Oncology
Cancer Care Units
Oncology Service, Hospital
Oncology Services, Hospital

The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.


Prominent lobed neuropils found in ANNELIDA and all ARTHROPODS except crustaceans. They are thought to be involved in olfactory learning and memory.


Horner Syndrome, Central
Miosis, Innervational Defect
Claude Bernard-Horner Syndrome
Bernard's Syndrome
Ophthalmoplegia, Sympathetic Ocular
Horner's Syndrome
Sympathetic Ocular-Ophthalmoplegia
Oculosympathetic Syndrome
Ptosis Sympathetic
Bernard Syndrome
Horner Syndrome, Acquired
Horner's Syndrome, Pupil
Horner Syndrome

A syndrome associated with defective sympathetic innervation to one side of the face, including the eye. Clinical features include MIOSIS; mild BLEPHAROPTOSIS; and hemifacial ANHIDROSIS (decreased sweating)(see HYPOHIDROSIS). Lesions of the BRAIN STEM; cervical SPINAL CORD; first thoracic nerve root; apex of the LUNG; CAROTID ARTERY; CAVERNOUS SINUS; and apex of the ORBIT may cause this condition. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp500-11)


HY Antigen
GA-1 Germ Cell Antigen
H-Y Antigen

A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.


Radiotherapy Dosage
Dosage, Radiotherapy

The total amount of radiation absorbed by tissues as a result of radiotherapy.


A general concept referring to the organization and administration of nursing activities.


Hearing Loss, Nonorganic
Hearing Loss, Functional
Hearing Loss, Psychogenic

Hearing loss without a physical basis. Often observed in patients with psychological or behavioral disorders.


Receptor, Galanin, Type 3
Galanin Receptor 3
GALR3 Galanin Receptor
Galanin-3 Receptor

A galanin receptor subtype with high affinity for GALANIN-LIKE PEPTIDE and low affinity for full length GALANIN and galanin peptide fragments.


Class E Basic Helix-Loop-Helix Protein 37

A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.


Services, Pharmaceutic
Services, Pharmaceutical
Pharmaceutical Care
Pharmacy Services
Services, Pharmacy
Pharmaceutic Services
Pharmaceutical Services

A pharmacy service model advocated by the pharmacy profession and approved by legislatures in many states and countries. This model expands the role of PHARMACISTS with additional training (CLINICAL PHARMACISTS) in a patient-centered evidence-based medication management program based on collaboration with physicians and patients.


A prominent projection of the ulna that articulates with the HUMERUS and forms the outer protuberance of the ELBOW JOINT.


Eosine Yellowish-(YS), Potassium, Sodium Salt

A versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with HEMATOXYLIN. It is also used in special culture media.


Low Cardiac Output
Cardiac Output, Low
Low Cardiac Output Syndrome

A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.


Population Projection
Population Forecast
Population Growth Estimation


Elastic Bandages
Compression Bandage
Elastic Compression Wraps
Compression Wraps
Compression Bandages

Strips of elastic material used to apply pressure to body parts to control EDEMA and aid circulation.


Mass of snow and/or ice falling down a mountain or incline.


Cytokine Receptor
Receptors, Cytokine
Receptors, Cytokines
Cytokine Receptors

Cell surface proteins that bind cytokines and trigger intracellular changes influencing the behavior of cells.


Osmoregulation
Osmotic Stress Regulating Pathway
Osmotic Stress Response

The response of cells in sensing a difference in OSMOTIC PRESSURE between the inside and outside of the cell. This response includes signaling from osmotic sensors to activate transcription factors, which in turn regulate the expression of osmocompensatory genes, all functioning to maintain CELL VOLUME and the water concentration inside the cells.


Amidopyrine Dimethylaminophenazone Amidophenazon Dimethyl-N-aminoantipyrine Dipyrine Amidazophen Amidophen Aminopyrine Aminophenazone Aminofenazone Dimethylaminoantipyrine Eufibron

A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.


The yellow or brown waxy secretions produced by vestigial apocrine sweat glands in the external ear canal.


Photoreceptors, Rod
Retinal Rod Photoreceptors
Retinal Rod Cells
Rod Photoreceptor Cells
Rod Photoreceptors
Retinal Rod Photoreceptor Cells
Retinal Rod
Rods (Retina)
Retinal Rod Cell
Retinal Rod Photoreceptor

Each rod cell contains highly differentiated compartments: include the outer segment (ROD OUTER SEGMENT), inner segment, connecting cilium, cell body, and synaptic terminal.


An organothiophosphorus cholinesterase inhibitor. It has been used as an acaricide and as an insecticide.


L-Ascorbate Oxidase
Ascorbino Dehydrogenase
Ascorbate Oxidase
Ascorbase

An enzyme that converts ascorbic acid to dehydroascorbic acid. EC 1.10.3.3.


Snail Family Transcription Factors
Slug Transcription Factors
Snail Transcription Factors

A transcription factor family characterized by the presence of several  C-terminal CYS2-HIS2 ZINC FINGERS. They function in many developmental processes including the induction of the EPITHELIAL-MESENCHYMAL TRANSITION; maintenance of embryonic MESODERM; growth arrest, CELL SURVIVAL; and CELL MIGRATION.


Acoustic Impedance Tests
Audiometry, Impedance
Tympanometry
Impedance Tests, Acoustic
Electroacoustic Impedance Tests

Objective tests of middle ear function based on the difficulty (impedance) or ease (admittance) of sound flow through the middle ear. These include static impedance and dynamic impedance (i.e., tympanometry and impedance tests in conjunction with intra-aural muscle reflex elicitation). This term is used also for various components of impedance and admittance (e.g., compliance, conductance, reactance, resistance, susceptance).


Synapse-Associated Protein 97
Discs Large Homolog 1 Protein

A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.


Evaluation Studies, Drug
Drug Evaluation Studies
Drug Evaluation

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.


Spinal Accessory Nerve Diseases
Accessory Nerve Diseases
Cranial Nerve XI Diseases
Eleventh Cranial Nerve Disease
Cranial Nerve Eleven Disorders
Cranial Nerve Eleven Diseases

Diseases of the eleventh cranial (spinal accessory) nerve. This nerve originates from motor neurons in the lower medulla (accessory portion of nerve) and upper spinal cord (spinal portion of nerve). The two components of the nerve join and exit the skull via the jugular foramen, innervating the sternocleidomastoid and trapezius muscles, which become weak or paralyzed if the nerve is injured. The nerve is commonly involved in MOTOR NEURON DISEASE, and may be injured by trauma to the posterior triangle of the neck.


Tosyllysyl Chloromethane
Tosyllysine Chloromethyl Ketone
Chlorotosylamidoaminoheptanone
TLCK

An inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process.


A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.


Doppler Color Echocardiography
Doppler Echocardiography, Color
Echocardiography, Doppler Color
Color Echocardiography, Doppler
Echocardiography, Color Flow
Color Doppler Echocardiography
Echocardiography, Doppler, Color
Echocardiography, Color Doppler
Color Flow Echocardiography

Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.


Hospital Nursing Staff
Staffs, Hospital Nursing
Hospital Nursing Staffs
Staff, Hospital Nursing
Nursing Staffs, Hospital
Nursing Staff, Hospital

Personnel who provide nursing service to patients in a hospital.


The primordial kidney that develops from the INTERMEDIATE MESODERM in the embryos of vertebrates, and is succeeded by the MESONEPHROS. In higher vertebrates and humans, the pronephros is a vestigial and transient structure.


Antiheparin Factor
Chemokine CXCL4
CXCL4 Chemokine
Platelet Factor 4
gamma-Thromboglobulin
Heparin Neutralizing Protein
PF4 (Platelet Factor 4)

A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.


Nuclear Factor-Erythroid 2 Transcription Factor

A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit.


A cell line established in 1962 from disaggregated Swiss albino mouse embryos. This fibroblast cell line is extremely popular in research.


Polyomavirus, JC
JC polyomavirus
John Cunningham Virus
JC Virus
Human Polyomavirus JC
Polyomavirus hominis 2

A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.


HMGI-C Protein
HMGA2 Protein
HMG I-C Protein

An AT-hook-containing (AT-HOOK MOTIFS) nuclear protein that is expressed predominantly in proliferating and undifferentiated mesenchymal cells.


Mitochondria
Mitochondrial Contraction
Mitochondrion

Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)


gp100 Melanocyte Differentiation Antigen

Melanocyte Lineage-Specific Antigen gp100

A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.


Diphenylmethyl Compounds
Benzhydryl Compounds

Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.


Cushing's Syndrome
Cushing Syndrome
Hypercortisolism

A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.


Penicillium notatum
Penicillium chrysogenum

A mitosporic fungal species used in the production of penicillin.


fes Proto-Oncogene Proteins
Feline Sarcoma Proto-Oncogene Protein
Proto-Oncogene Proteins c-fes
Proto-Oncogene Protein c-fes
c-fes Proteins
Proto-Oncogene Protein fes
fps Proto-Oncogene Protein
c-fes Tyrosine Kinase
c-fes Proto-Oncogene Proteins

Proto-oncogene proteins fes are protein-tyrosine kinases with a central SH2 DOMAIN. It has been implicated in SIGNAL TRANSDUCTION PATHWAYS for CELL DIFFERENTIATION of a variety of cell types including MYELOID PROGENITOR CELLS. Fes proto-oncogene proteins also bind TUBULIN and promote MICROTUBULE assembly.


PSK-J3 Kinase
Cyclin D-Dependent Kinase CDK4
p34PSK-J3 Kinase
Cyclin-Dependent Kinase 4
Cell Division Protein Kinase 4
Cdk4 Cyclin-Dependent Kinase
Cdk4 Protein
Cdk4 Protein Kinase

Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16.


Leukemia Inhibitory Factor-Oncostatin M Shared Receptor

Oncostatin M-Leukemia Inhibitory Factor Shared Receptor

Cell surface receptors formed from the dimerization of LIF RECEPTOR ALPHA SUBUNIT with CYTOKINE RECEPTOR GP130. Although originally described as receptors for LEUKEMIA INHIBITORY FACTOR these receptors also bind the closely-related protein ONCOSTATIN M and are referred to as both LIF receptors and type I oncostatin M receptors.


Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.


Ctenophora
Mnemiopsis
Beroe
Comb Jellies
Ctenophores
Sea Walnuts

Genus of ctenophore in the family Bolinopsidae.


Antigen Ki67
MIB-1 Antigen
Antigen Ki-67
Ki-67 Antigen
MIB-1 Protein

A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.


Driver Distraction
Inattentive Driving
Distracted Driving
Driving While Distracted

Behavior which detracts from the focus necessary to operate an automobile safely.


Cerebrospinal Fluid
Cerebro Spinal Fluid

A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.


Antiparkinson Agents
Antiparkinson Drugs
Antiparkinsonians
Antiparkinsonian Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.


School Uniforms
Clothing
Military Uniforms
Nurse Uniforms
Uniforms
Clothes
Garments

Distinctive apparel worn by members of an organization.


Mastocytoma, Malignant
Sarcoma, Mast-Cell
Mast-Cell Sarcoma

A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.


Bonzo Receptor
CXC Chemokine Receptor 6
Receptors, CXCR6
STRL33 Protein

CXCR receptors that are specific for CHEMOKINE CXCL16. They are expressed by lymphoid tissues, activated T-cells, and also function as co-receptors for SIMIAN IMMUNODEFICIENCY VIRUSES; HIV-2; and HIV-1 infection of MACROPHAGES.


A plant species of the family BRASSICACEAE best known for the edible roots.


Replication Factor A Single-Stranded DNA-Binding Protein

A single-stranded DNA-binding protein that is found in EUKARYOTIC CELLS. It is required for DNA REPLICATION; DNA REPAIR; and GENETIC RECOMBINATION.


A group of compounds with the general formula M10(PO4)6(OH)2, where M is barium, strontium, or calcium. The compounds are the principal mineral in phosphorite deposits, biological tissue, human bones, and teeth. They are also used as an anticaking agent and polymer catalysts. (Grant & Hackh's Chemical Dictionary, 5th ed)


para-Hydroxyphenylpyruvate Oxidase
P-Hydroxyphenylpyruvate Hydroxylase
para-Hydroxyphenylpyruvate Hydroxylase
P-Hydroxyphenylpyruvate Oxidase
4-Hydroxyphenylpyruvate Dioxygenase

An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27.


The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.


Phase of the CELL CYCLE following G1 and preceding G2 when the entire DNA content of the nucleus is replicated. It is achieved by bidirectional replication at multiple sites along each chromosome.


Enterobacteria phage N4
N4 Phage
Coliphage N4
Phage N4
Bacteriophage N4

A species in the genus N4-like viruses, in the family PODOVIRIDAE, that infects E. coli.


Deoxyepinephrine Deoxyadrenaline Desoxyepinephrine Epinine Methyldopamine Desoxyadrenaline


Tumor Necrosis Factor Receptor Superfamily, Member 13C

A member of the tumor necrosis factor receptor superfamily that specifically binds B-CELL ACTIVATING FACTOR. It is found on B-LYMPHOCYTES and plays a role in maturation and survival of B-cells. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Evaluation Research, Nursing
Research, Nursing Evaluation
Nursing Program Evaluation
Nursing Evaluation Research
Program Evaluation, Nursing
Evaluation, Nursing Program
Evaluation Studies, Nursing

Research carried out by nurses that uses interviews, data collection, observation, surveys, etc., to evaluate nursing, health, clinical, and nursing education programs and curricula, and which also demonstrates the value of such evaluation.


A subfamily of snakes commonly known as pit vipers, crotaline snakes, or pit adders in the family VIPERIDAE. They are distinguished by a deep pit called a fossa or loreal, which functions as a heat-sensing organ located between the eye and nostril on either side of the head.


A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.


Sodium Phytate
Phytic Acid
Phytin
Inositol Hexaphosphate
Inositol Hexakisphosphate
Phytate
Calcium Phytate

Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.


The family Hirundinidae, comprised of small BIRDS that hunt flying INSECTS while in sustained flight.


Mithramycin
Plicamycin
Aureolic Acid
Mitramycin

A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.


Bacteroides corrodens
Eikenella corrodens

Gram-negative bacteria isolated from infections of the respiratory and intestinal tracts and from the buccal cavity, intestinal tract, and urogenital tract. They are probably part of the normal flora of man and animals.


Isovaleryl CoA Dehydrogenase
Isovaleryl-Coenzyme A Dehydrogenase
Isovaleryl-CoA Dehydrogenase

A mitochondrial flavoprotein, this enzyme catalyzes the oxidation of 3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA using FAD as a cofactor. Defects in the enzyme, is associated with isovaleric acidemia (IVA).


Substances found in PLANTS that have antigenic activity.


Receptors, Neurotensin
Neurotensin Receptors
Neurotensin Receptor

Cell surface proteins that bind neurotensin with high affinity and trigger intracellular changes which influence the behavior of cells. Neurotensin and neurotensin receptors are found in the central nervous system and in the periphery.


Histocompatibility, Maternal-Fetal
Maternal-Fetal Histocompatibility
Maternal-Fetal Immunocompatibility

The degree of antigenic similarity between tissues of the mother and those of the FETUS. Maternal-fetal histocompatibility can determine the acceptance and health of the fetus.