Mannose-6-Phosphate Receptor-Binding Protein 1

47 kDa Mannose 6-Phosphate Receptor-Binding Protein

A perilipin that localizes to LIPID DROPLETS; CYTOPLASM; ENDOSOMES; and PLASMA MEMBRANE, especially in MACROPHAGES. It functions as a transporter of free fatty acids to lipid droplets to promote their biogenesis and growth. It is also required for the transport of the MANNOSE-6-PHOSPHATE RECEPTOR from endosomes to the TRANS-GOLGI NETWORK. Its structure consists of four helix bundles that interact with the hydrophobic lipid droplet surface.


The act or practice of killing or allowing death from natural causes, for reasons of mercy, i.e., in order to release a person from incurable disease, intolerable suffering, or undignified death. (from Beauchamp and Walters, Contemporary Issues in Bioethics, 5th ed)


Atelectasis of the right middle pulmonary lobe, with chronic pneumonitis. (Dorland, 27th ed)


Athetosis
Hammond Disease
Athetoid Movements
Hammond's Disease

A dyskinesia characterized by an inability to maintain the fingers, toes, tongue, or other body parts in a stable position, resulting in continuous slow, sinusoidal, and flowing involuntary movements. This condition is frequently accompanied by CHOREA, where it is referred to as choreoathetosis. Athetosis may occur as a manifestation of BASAL GANGLIA DISEASES or DRUG TOXICITY. (From Adams et al., Principles of Neurology, 6th ed, p76)


Health Insurance for Aged and Disabled, Title 18

Insurance, Health, for Aged and Disabled

Health Insurance for Aged, Disabled, Title 18

Federal program, created by Public Law 89-97, Title XVIII-Health Insurance for the Aged, a 1965 amendment to the Social Security Act, that provides health insurance benefits to persons over the age of 65 and others eligible for Social Security benefits. It consists of two separate but coordinated programs: hospital insurance (MEDICARE PART A) and supplementary medical insurance (MEDICARE PART B). (Hospital Administration Terminology, AHA, 2d ed and A Discursive Dictionary of Health Care, US House of Representatives, 1976)


The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.


The study and practice of medicine by direct examination of the patient.


Thin strands of transparent material, usually glass, that are used for transmitting light waves over long distances.


Mechanical or anoxic trauma incurred by the infant during labor or delivery.


Hematoma, Basal Ganglia
Hemorrhage, Basal Ganglia
Basal Ganglionic Hemorrhage
Basal Ganglia Hemorrhage


Psychology, Comparative
Comparative Psychology

The branch of psychology concerned with similarities or differences in the behavior of different animal species or of different races or peoples.


Ventricular Pre-Excitation with Arrhythmia

Anomalous Ventricular Excitation Syndrome

Auriculoventricular Accessory Pathway Syndrome

A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.


A heterodimeric cytokine composed of the IL-27p28 and EBI3 subunits. It is produced primarily by antigen-presenting cells after stimulation by microbial products or inflammatory mediators.


Sterile Alpha Motif
SAM Domain
Sterile Alpha Motif Domain

A putative protein interaction module, approximately 70 amino acids long, that forms a small five-helix bundle with two large interfaces which may homo- and hetero-oligomerize, or bind non-sterile-alpha motif targets. The sterile alpha motif is present in a wide variety of eukaryotic proteins that function in diverse biological processes.


Seroepidemiological Study
Study, Seroepidemiologic
Seroprevalence
Seroepidemiologic Study
Studies, Seroepidemiologic
Seroepidemiologic Studies

EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.


Articulationes pedis
Intermetatarsal Joint
Foot Joints

The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.


The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).


Used as feed supplement for sheep and cattle since it is a good non-protein nitrogen source. In strongly alkaline solution biuret gives a violet color with copper sulfate.


An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.


KCNA3 Potassium Channel
Kv1.3 Potassium Channel

A delayed rectifier subtype of shaker potassium channels that is the predominant VOLTAGE-GATED POTASSIUM CHANNEL of T-LYMPHOCYTES.


Herpes Simplex Virus 1
Human Herpesvirus 1
HHV-1
Herpesvirus 1 (alpha), Human
Herpesvirus 1, Human
Herpes Simplex Virus Type 1
HSV-1

The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.


Fracture Fixation
Skeletal Fixation
Fracture Reduction

The use of metallic devices inserted into or through bone to hold a fracture in a set position and alignment while it heals.


Group Hospitalization
Hospitalization Insurance
Insurance, Hospitalization

Health insurance providing benefits to cover or partly cover hospital expenses.


Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)


Breathing Mechanics
Respiratory Mechanics

The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.


Steroid 18-Hydroxylase
Cytochrome P450 11B2
Cytochrome P-450 CYP11B2
CYP 11B2
P450c11AS
Cytochrome P450Aldo
Cytochrome P-450c11AS
CYP11B2
Aldosynthase
Aldosterone Synthase Cytochrome P-450
Aldosterone Synthase

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.


Ribosomal Frame Shift
Ribosomal Frameshifting
Frameshifting, Ribosomal
Ribosomal Frameshift
Ribosomal Frame Shifting
Frameshifting, Translational

A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.


Proto-Oncogene Protein c-ret
Proto-Oncogene Proteins c-ret
ret Proto-Oncogene Proteins
c-ret Protein
Receptor Tyrosine Kinase RET
Proto-Oncogene Protein Ret

Receptor protein-tyrosine kinases involved in the signaling of GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR ligands. They contain an extracellular cadherin domain and form a receptor complexes with GDNF RECEPTORS. Mutations in ret protein are responsible for HIRSCHSPRUNG DISEASE and MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.


Coagulation, Laser
Laser Thermocoagulation
Laser Coagulation
Thermocoagulation, Laser

The use of green light-producing LASERS to stop bleeding. The green light is selectively absorbed by HEMOGLOBIN, thus triggering BLOOD COAGULATION.


Hypertension, Pulmonary, of Newborn, Persistent

Pulmonary Hypertension, Familial Persistent, of the Newborn

Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies

Persistent Pulmonary Hypertension of Newborn

Familial Persistent Pulmonary Hypertension of the Newborn

A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).


Pattern Recognition, Automated
Pattern Recognition System
Automated Pattern Recognition

In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)


Infant, Extremely Low Birth Weight
Extremely Low Birth Weight Infant

An infant whose weight at birth is less than 1000 grams (2.2 lbs), regardless of GESTATIONAL AGE.


Early Pregnancy Loss
Miscarriage
Abortion, Tubal
Abortion, Spontaneous
Spontaneous Abortion

A loss of PREGNANCY from natural causes before the 20th week of pregnancy. (2017/18 ICD-10-CM)


Reperfusion Damage
Reperfusion Injury
Ischemia-Reperfusion Injury
Injury, Reperfusion
Injury, Ischemia-Reperfusion

Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.


Loss of scalp and body hair involving microscopically inflammatory patchy areas.


Finger Bones
Finger Phalanges
Bones of Fingers
Phalanges of Fingers

Bones that make up the SKELETON of the FINGERS, consisting of two for the THUMB, and three for each of the other fingers.


Burkholderia cocovenenans
Burkholderia gladioli

A species of gram-negative, aerobic bacteria that acts as both a human and plant pathogen.


Zygote
Fertilized Egg
Ovum, Fertilized
Fertilized Ovum

The fertilized OVUM resulting from the fusion of a male and a female gamete.


Endoplasmic Reticulum, Granular
Endoplasmic Reticulum, Rough

A type of endoplasmic reticulum (ER) where polyribosomes are present on the cytoplasmic surfaces of the ER membranes. This form of ER is prominent in cells specialized for protein secretion and its principal function is to segregate proteins destined for export or intracellular utilization.


PEX Phosphate Regulating Neutral Endopeptidase

Phosphate Regulating Endopeptidase Homolog, X-Linked

X-Linked Phosphate Regulating Endopeptidase Homolog

PHEX Phosphate Regulating Neutral Endopeptidase

A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.


A method of payment for health services in which an individual or institutional provider is paid a fixed, per capita amount without regard to the actual number or nature of services provided to each patient.


A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.


Rubivirus Infections
Infections, Rubivirus

Virus diseases caused by the RUBIVIRUS genus, of the family TOGAVIRIDAE.


Susceptibility, Disease
Diathesis
Disease Susceptibility

A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.


A type of shock that occurs as a result of a surgical procedure.


Premature Death
Death, Premature
Premature Mortality
Mortality, Premature

Deaths that occur before LIFE EXPECTANCY is reached within a given population.


Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys.


Chernobyl Nuclear Accident, Chornobyl, Ukraine, 1986

April 25th -26th, 1986 nuclear power accident that occurred at Chernobyl in the former USSR (Ukraine) located 80 miles north of Kiev.


Iridocyclitis
Cyclitis, Heterochromic
Heterochromic Cyclitis

Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of the iris, and constricted, sluggish pupil. Symptoms include radiating pain, photophobia, lacrimation, and interference with vision.


Neutrophil Band Cells
Leukocytes, Polymorphonuclear
LE Cells
Neutrophils
Polymorphonuclear Leukocytes


ATP Synthetase Complexes
ADP Kinase
ATP Synthetase Complex
ATP-ADP Kinase
ADP Kinases

Multisubunit enzyme complexes that synthesize ADENOSINE TRIPHOSPHATE from energy sources such as ions traveling through channels.


Corpus Luteum Regression
Luteal Regression
Luteolysis

Degradation of CORPUS LUTEUM. In the absence of pregnancy and diminishing trophic hormones, the corpus luteum undergoes luteolysis which is characterized by the involution and cessation of its endocrine function.


Mesoinositol Chiro-Inositol Myoinositol Inositol

An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.


The use of biological agents in TERRORISM. This includes the malevolent use of BACTERIA; VIRUSES; or other BIOLOGICAL TOXINS against people, ANIMALS; or PLANTS.


Thalitone Phthalamudine Hygroton Chlortalidone Oxodoline Chlorthalidone Chlorphthalidolone

A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.


Fragile Sites, Chromosome
Chromosome Fragile Sites

Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)


Unmarried
Never Married
Maritally Unattached
Single Person


Fungi, Unclassified
Fungi, incertae sedis

Fungi whose taxonomic relationships have not been authoritatively established.


Mesylates Methylenesulfonates Mesilate Methanesulfonates Mesilates Mesylate

Organic salts or esters of methanesulfonic acid.


Extracts of the THYMUS GLAND that contain specific factors, peptides, and proteins with specific biological activities.


Genetic Selection
Selection, Genetic
Natural Selection

Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.


Protein Renaturation
Renaturation, Protein

The reconstitution of a protein's activity following denaturation.


A plant genus of the family BORAGINACEAE.


Ventricular Premature Complex
Extrasystole, Ventricular
Premature Ventricular Beats
Premature Ventricular Complex
Premature Ventricular Contractions
Ventricular Ectopic Beats
Ventricular Premature Complexes

A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.


Aspartate Carbamoyltransferase
Aspartate Transcarbamylase
Co(II)-Aspartate Transcarbamoylase
Ni(II)-Aspartate Transcarbamoylase

An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.


Catecholestrogens
Catechol Estrogens
Estrogens, Catechol

2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.


Cranial Neuropathies, Traumatic
Cranial Nerve Injuries

Dysfunction of one or more cranial nerves causally related to a traumatic injury. Penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA; NECK INJURIES; and trauma to the facial region are conditions associated with cranial nerve injuries.


Regulation of Gene Expression, Neoplastic

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.


The posterior filiform portion of the spermatozoon (SPERMATOZOA) that provides sperm motility.


Infantile Form of Phytanic Acid Storage Disease

An early onset form of phytanic acid storage disease with clinical and biochemical signs different from those of REFSUM DISEASE. Features include MENTAL RETARDATION; SENSORINEURAL HEARING LOSS; OSTEOPOROSIS; and severe liver damage. It can be caused by mutation in a number of genes encoding proteins involving in the biogenesis or assembly of PEROXISOMES.


Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).


Adenosine Deaminase Complexing Protein 2

A serine protease that catalyses the release of an N-terminal dipeptide. Several biologically-active peptides have been identified as dipeptidyl peptidase 4 substrates including INCRETINS; NEUROPEPTIDES; and CHEMOKINES. The protein is also found bound to ADENOSINE DEAMINASE on the T-CELL surface and is believed to play a role in T-cell activation.


A plant species of the genus ATROPA, family SOLANACEAE that contains ATROPINE; SCOPOLAMINE; BELLADONNA ALKALOIDS and other SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for SOLANUM.


Adoptive Immunity
Immunity, Adaptive
Acquired Immunity
Adaptive Immunity
Adaptive Immune Response

Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE).


An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.


Catechol O-Methyltransferase
Catechol Methyltransferase
Catechol-O-Methyltransferase

Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.


Noxytiolin Noxitiolinum Noxythiolin Noxyflex-S Noxitiolin N-Methyl-N''-(hydroxymethyl)thiourea

Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for burns.


An HLA-DR antigen associated with HLA-DRB1 CHAINS that are encoded by DRB1*01 alleles.


GRB7 Protein
GRB7 Adaptor Protein
Growth Factor Receptor-Bound Protein-7

A SH2 DOMAIN-containing protein that mediates SIGNAL TRANSDUCTION pathways from multiple CELL SURFACE RECEPTORS, including the EPHB1 RECEPTOR. It interacts with FOCAL ADHESION KINASE and is involved in CELL MIGRATION.


A species of shark in the family SQUALIDAE, used for its oil (SQUALENE) and as fish meal. It also figures heavily in biological research, especially with reference to its RECTAL GLAND in studies of WATER-ELECTROLYTE BALANCE.


Risk Sharing, Financial
Financial Risk Sharing

Any system which allows payors to share some of the financial risk associated with a particular patient population with providers. Providers agree to adhere to fixed fee schedules in exchange for an increase in their payor base and a chance to benefit from cost containment measures. Common risk-sharing methods are prospective payment schedules (PROSPECTIVE PAYMENT SYSTEM), capitation (CAPITATION FEES), diagnosis-related fees (DIAGNOSIS-RELATED GROUPS), and pre-negotiated fees.


Amyloglucosidase
1,4-alpha-Glucosidase, Exo
Exo-1,4-alpha-Glucosidase
Glucoamylase
Glucoamylase G2
Glucoamylase G1
Glucan 1,4-alpha-Glucosidase
gamma-Amylase

An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.


Goldswite
Nozucar
NutraSweet
SC-18862
Canderel
Aspartame
Aspartylphenylalanine Methyl Ester
Milisucre
Hermesetas Gold
Tri-Sweet
Methyl Aspartylphenylalanine

Flavoring agent sweeter than sugar, metabolized as PHENYLALANINE and ASPARTIC ACID.


Compounds that contain a BENZENE ring fused to a furan ring.


A family of bacteria in the order RICKETTSIALES which inhabit RED BLOOD CELLS and other types of cells, causing disease in both animals and humans.


A selenium compound with the molecular formula H2SO3. It used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION.


Anatomy, Cross-Sectional
Sectional Anatomy
Anatomy, Sectional
Cross-Sectional Anatomy

Descriptive anatomy based on three-dimensional imaging (IMAGING, THREE-DIMENSIONAL) of the body, organs, and structures using a series of computer multiplane sections, displayed by transverse, coronal, and sagittal analyses. It is essential to accurate interpretation by the radiologist of such techniques as ultrasonic diagnosis, MAGNETIC RESONANCE IMAGING, and computed tomography (TOMOGRAPHY, X-RAY COMPUTED). (From Lane & Sharfaei, Modern Sectional Anatomy, 1992, Preface)


Autoprothrombin II
Plasma Thromboplastin Component
Factor IX Complex
Coagulation Factor IX
Christmas Factor
Factor Nine
Factor IX Fraction
Blood Coagulation Factor IX
Factor IX
Factor 9

Storage-stable blood coagulation factor acting in the intrinsic pathway of blood coagulation. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).


Egg Hypersensitivity
Egg Allergy
Hypersensitivity, Egg
Allergy, Egg

Allergic reaction to eggs that is triggered by the immune system.


SGLT1 Protein
Sodium-Glucose Cotransporter 1
SLC5A1 Protein
Sodium-Glucose Transporter 1

The founding member of the sodium glucose transport proteins. It is predominately expressed in the INTESTINAL MUCOSA of the SMALL INTESTINE.


Decomposed organic matter. It consists of numerous breakdown substances from plants including SUGARS; AMINO ACIDS; LIGNIN; FATS; and HUMIC SUBSTANCES.


Postweaning Multisystemic Wasting Syndrome, Porcine

Porcine Postweaning Multisystemic Wasting Syndrome

A worldwide emerging disease of weaned piglets first recognized in swine herds in western Canada in 1997. This syndrome is characterized by progressive weight loss, rapid (tachypnea) and difficult (dyspnea) breathing, and yellowing of skin. PMWS is caused by PORCINE CIRCOVIRUS infection, specifically type 2 or PCV-2.


ABC Transporters
ATP-Binding Cassette Transporters

A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.


Thiamcol Dextrosulfenidol Urfamycin Thiomycetin Thiamphenicol Raceophenidol Thiophenicol Vicemycetin

A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.


A pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.


The anteriorly located rigid section of the PALATE.


Institutionalized Adolescent
Adolescent, Institutionalized

An adolescent who is receiving long-term in-patient services or who resides in an institutional setting.


Glycerophosphate Ethers
Ether Phospholipids
1-Alkyl-2-Acylphosphatidates
Phospholipid Ethers
Glycerol Phosphate Ethers
Ether Phosphatidates

Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.


Human Parathyroid Hormone (1-34)
Parathar
hPTH (1-34)
Teriparatide
Forteo
Teriparatide Acetate

A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)


A numerical system of measuring the rate of BLOOD GLUCOSE generation from a particular food item as compared to a reference item, such as glucose = 100. Foods with higher glycemic index numbers create greater blood sugar swings.


Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.


Introversion, Psychology
Introversion (Psychology)
Introversion
Introversion, Psychological

A state in which attention is largely directed inward upon one's self.


Protein-Tyrosine-Phosphatase
Phosphotyrosine Phosphatase
Protein Tyrosine Phosphatases
Tyrosyl Phosphoprotein Phosphatase
Phosphotyrosyl Protein Phosphatase
Protein-Tyrosine Phosphatase
PTPase

An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.


Marenostrin
Mediterranean Fever Protein
MEFV Protein
Pyrin
TRIM20 Protein

A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.


Mansonellosis
Dipetalonema perstans Infection
Mansonella perstans Infections
Acanthocheilonema perstans Infection
Mansonelliasis

Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.


Lymphoma, Primary Cutaneous Anaplastic Large Cell

Primary Cutaneous CD30-positive Large T-Cell Lymphoma

Primary Cutaneous Anaplastic Large Cell Lymphoma

Anaplastic lymphoma of the skin which develops as a primary neoplasm expressing the CD30 ANTIGEN. It is characterized by solitary nodules or ulcerated tumors.


Small Molecular Weight RNA
RNA, Small Nuclear
snRNA
Chromatin-Associated RNA
Small Nuclear RNA
Low Molecular Weight Nuclear RNA

Short chains of RNA (100-300 nucleotides long) that are abundant in the nucleus and usually complexed with proteins in snRNPs (RIBONUCLEOPROTEINS, SMALL NUCLEAR). Many function in the processing of messenger RNA precursors. Others, the snoRNAs (RNA, SMALL NUCLEOLAR), are involved with the processing of ribosomal RNA precursors.


Agouti Switch Protein
ASIP Protein
Agouti Signaling Protein
Agouti Protein

A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.


Dental Office
Dental Offices
Offices, Dental
Office, Dental

The room or rooms in which the dentist and dental staff provide care. Offices include all rooms in the dentist's office suite.


Mevinolin
Lovastatin
Monacolin K
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha-Isomer
Mevacor
MK-803
6-Methylcompactin

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.


Myopathic Conditions
Muscle Disorders
Muscular Diseases
Myopathies

Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.


Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).


Thymosin. A family of heat-stable, polypeptide hormones secreted by the thymus gland. Their biological activities include lymphocytopoiesis, restoration of immunological competence and enhancement of expression of T-cell characteristics and function. They have therapeutic potential in patients having primary or secondary immunodeficiency diseases, cancer or diseases related to aging.


Allergy, Wheat
Hypersensitivity, Wheat
Wheat Hypersensitivity
Wheat Allergy

Allergic reaction to wheat that is triggered by the immune system.


Estrogen Receptor Modulators, Selective
Selective Estrogen Receptor Modulator
SERMs
SERM
Estrogen Receptor Modulator, Selective
Selective Estrogen Receptor Modulators

A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)


Glossoptosis, Micrognathia, and Cleft Palate

Congenital malformation characterized by MICROGNATHIA or RETROGNATHIA; GLOSSOPTOSIS and CLEFT PALATE. The mandibular abnormalities often result in difficulties in sucking and swallowing. The syndrome may be isolated or associated with other syndromes (e.g., ANDERSEN SYNDROME; CAMPOMELIC DYSPLASIA). Developmental mis-expression of SOX9 TRANSCRIPTION FACTOR gene on chromosome 17q and its surrounding region is associated with the syndrome.


Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)


Myoadenylate Deaminase
AMP Aminohydrolase
AMP Deaminase
Adenylate Deaminase
5'-AMP Deaminase
AMP Aminase

An enzyme that catalyzes the deamination of AMP to IMP. EC 3.5.4.6.


Tertiary Referral Hospital
Tertiary Hospital
Tertiary Care Centers
Tertiary Referral Center

A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.


The collective name for the boron hydrides, which are analogous to the alkanes and silanes. Numerous boranes are known. Some have high calorific values and are used in high-energy fuels. (From Grant & Hackh's Chemical Dictionary, 5th ed)


(1 beta,2 alpha,11 beta,12 alpha,15 beta(S))-11,20-Epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)picras-3-en-16-one. A quassinoid (Simaroubolide) from Simaruba glauca, a tropical shrub. It has been used as an antiamebic agent and is found to be cytotoxic. It may be of use in cancer chemotherapy.


Migration Inhibition Factors, Macrophage

Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.


Avian Infectious Laryngotracheitis Virus

Infectious Laryngotracheitis Virus, Avian

The type species of the genus ILTOVIRUS found on every continent and affecting mainly chickens and occasionally pheasants.


Abnormal accumulation of fluid in tissues of any part of the LARYNX, commonly associated with laryngeal injuries and allergic reactions.


Molecular Dynamics Simulations
Molecular Dynamics Simulation
Molecular Dynamics

A computer simulation developed to study the motion of molecules over a period of time.


B7-Related Protein 1
B7-H2 Antigen
B7H2 Antigen
B7-Like Protein Gl50
Antigens, CD275
B7-H2 Ligand
B7-Related Protein-1
Inducible T-Cell Co-Stimulator Ligand
CD275 Antigen

A B7 antigen that binds specifically to INDUCIBLE T-CELL CO-STIMULATOR PROTEIN on T-CELLS. It provides a costimulatory signal for T-cell proliferation and cytokine secretion.


Endocarditis, Bacterial
Bacterial Endocarditides
Bacterial Endocarditis
Endocarditides, Bacterial

Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.


A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.


Agenesis of Corpus Callosum with Infantile Spasms and Ocular Abnormalities

Corpus Callosum, Agenesis Of, With Chorioretinal Abnormality

Callosal Agenesis and Ocular Abnormalities

Agenesis of Corpus Callosum with Chorioretinal Abnormality

A rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM, resulting in infantile spasms, MENTAL RETARDATION, and lesions of the RETINA or OPTIC NERVE.


Infectious Skin Diseases
Skin Diseases, Infectious

Skin diseases caused by bacteria, fungi, parasites, or viruses.


Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.


The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.


Cummingtonite-Grunerite
Asbestos, Amosite
Amosite Asbestos
Amosite

Asbestos, grunerite. A monoclinic amphibole form of asbestos having long fibers and a high iron content. It is used in insulation. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


Femoracetabular Impingement
Femoroacetabular Impingement
Femoroacetabular Impingement Syndrome
Femoro-Acetabular Impingement

A pathological mechanical process that can lead to hip failure. It is caused by abnormalities of the ACETABULUM and/or FEMUR combined with rigorous hip motion, leading to repetitive collisions that damage the soft tissue structures.


CD51 Antigen
CD51 Antigens
Integrin alphaV
Antigens, CD51
Integrin alpha V
alphav Integrin
alpha(V) Integrin

An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.


Compact Bone
Substantia Compacta
Compact Bone Tissue
Compact Bones
Cortical Bone

A type of osseous tissue which makes up the outer layer of bone. It is dense, rigid, strong, and forms concentric lamellar OSTEONS.


Tritirachium Alkaline Proteinase
Proteinase K
Endopeptidase K
Protease K

An enzyme that catalyzes the hydrolysis of keratin, and of other proteins with subtilisin-like specificity. It hydrolyses peptide amides. Endopeptidase K is from the mold Tritirachium album Limber. (Enzyme Nomenclature, 1992) EC 3.4.21.64.


A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine.


Platelet Membrane Glycoprotein Heterodimer Ia-IIa

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.


Diploma Programs, Nursing
Education, Nursing, Diploma Programs
Nursing Education, Diploma Programs

Programs usually offered in hospital schools of nursing leading to a registered nurse diploma (RN). Graduates are eligible for state examination for licensure as RN (Registered Nurse).


Endovascular Techniques
Intravascular Procedures
Endovascular Procedures
Intravascular Techniques

Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.


Transplantation, Fetal Tissue
Grafting, Fetal Tissue
Fetal Tissue Transplantation
Fetal Tissue Donation

Transference of fetal tissue between individuals of the same species or between individuals of different species.


Nitroanisole O Demethylase
Nitroanisole O-Demethylase

Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.


WT1 Gene Product
WT1 Proteins
WT1 Protein

Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.


Radiographic techniques used in dentistry.


Talampicillin
BRL-8988
Phthalidyl Ampicillin
Talampicillin Hydrochloride
Talpen

An ester of AMPICILLIN which is readily hydrolyzed on absorption to release ampicillin. It is well absorbed from the gastrointestinal tract resulting in a greater bioavailability of ampicillin than can be achieved with equivalent doses of ampicillin.


Retortamonads Retortamonas Retortamonadidae Chilomastix Retortamonadida

A family of flagellated EUKARYOTES that live in the intestines of several invertebrate and vertebrate species.


Outside services provided to an institution under a formal financial agreement.


Peroxisome Proliferator-Activated Receptor delta

A nuclear transcription factor. It is activated by PROSTACYCLIN.


The parts of the messenger RNA sequence that do not code for product, i.e. the 5' UNTRANSLATED REGIONS and 3' UNTRANSLATED REGIONS.


Clathrin Assembly Protein Complex gamma Subunits

A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.


Power, Psychological
Power (Psychology)
Power, Personal
Power, Social
Power
Power, Professional

The exertion of a strong influence or control over others in a variety of settings--administrative, social, academic, etc.


A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.


Ethylmethylglutarimide Megimide Bemegride Methetharimide

A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.


Clinical Laboratory Services
Laboratory Services, Clinical

Organized services provided by MEDICAL LABORATORY PERSONNEL for the purpose of carrying out CLINICAL LABORATORY TECHNIQUES used for the diagnosis, treatment, and prevention of disease.


Forkhead Box Protein O1
FOXO1 Protein
Forkhead in Rhabdomyosarcoma Protein

A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.


Religion and Medicine
Medicine and Religion

The interrelationship of medicine and religion.


Linum
Linseed
Linum usitatissimum
Flaxseed
Flax

A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.


Post-Synaptic Potential Summation
Spatial Summation, Neurophysiology
Neurophysiology Summation
Postsynaptic Potential Summation
Temporal Summation, Neurophysiology

Physiological integration of multiple SYNAPTIC POTENTIAL signals to reach the threshold and initiate postsynaptic ACTION POTENTIALS. In spatial summation stimulations from additional synaptic junctions are recruited to generate s response. In temporal summation succeeding stimuli signals are summed up to reach the threshold. The postsynaptic potentials can be either excitatory or inhibitory (EPSP or IPSP).


5-Iodo-2'-deoxyuridine
Idoxuridine, 123I-Labeled
IUdR
Iododeoxyuridine
Kerecide
Idoxuridine, 3H-Labeled
SK&F-14287
Idoxuridine, Radical Ion (1-)
Idoxuridine
Allergan 211
Oftan-IDU
Idoxuridine, 131I-Labeled
Idoxuridine, 125I-Labeled
5-Iododeoxyuridine
Idoxuridine, Radical Ion (+1)
NSC-39661
Herplex Liquifilm
Stoxil

An analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.


Peripheral Stem Cells
Peripheral Blood Stem Cells

Hematopoietic stem cells found in peripheral blood circulation.


A solid form of carbon dioxide used as a refrigerant.


Patient Portal
Patient Internet Portals
Patient Web Portals
Patient Web Portal
Patient Portals

A secure online website that provides patients convenient 24-hour access to personal health information via an Internet connection.


Desquamating Agents
Keratolytic Agents
Skin-Peeling Agents

Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.


A trihydroxy bile salt that is used as a digestive aid in dietary supplements. It is used in culture media and in conjunction with PAPAIN and PANCREATIN.


An adenine arabinonucleoside derivative that acts as an antineoplastic antimetabolite. It is used in the treatment of ACUTE LYMPHOID LEUKEMIA in pediatric patients who have relapsed.


Molecular oxygen, O2, having two unpaired electrons in its most stable form.


The study of life and ECOLOGIC SYSTEMS in bodies of FRESHWATER.


Equine Lentiviruses
Lentiviruses, Equine

A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in horses.


Riot Control Agents, Chemical
Chemical Riot Control Agents

Chemical substances which are employed during a riot in order to control or disperse the rioting parties.


Tuberculosis, Ocular
Ocular Tuberculosis

Tuberculous infection of the eye, primarily the iris, ciliary body, and choroid.


A plant genus of the family BETULACEAE that is distinguished from birch (BETULA) by its usually stalked winter buds and by cones that remain on the branches after the small, winged nutlets are released.


Glycerol-3-Phosphate Dehydrogenase
Glycerophosphate Dehydrogenase
Glycerophosphate Oxidase
Glycerolphosphate Dehydrogenase
Alpha-Glycerophosphate Dehydrogenase


Hemagglutinins, Viral
Viral Hemagglutinins
Viral Hemagglutinin

Specific hemagglutinin subtypes encoded by VIRUSES.


Purpura, Thrombopenic
Purpura, Thrombocytopenic

Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.


Wernicke Polioencephalitis, Superior Hemorrhagic

Wernicke's Superior Hemorrhagic Polioencephalitis

Wernicke Superior Hemorrhagic Polioencephalitis

Wernicke's Polioencephalitis, Superior Hemorrhagic

An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)


Emtricitabine Rilpivirine Tenofovir Drug Combination

Emtricitabine, Rilpivirine, Tenofovir Drug Combination

A pharmaceutical preparation that contains emtricitabine, rilpivirine and tenofovir disoproxil fumarate. It is used to treat HIV INFECTIONS.


A family of New World monkeys in the infraorder PLATYRRHINI, consisting of nine subfamilies: ALOUATTINAE; AOTINAE; Atelinae; Callicebinae; CALLIMICONINAE; CALLITRICHINAE; CEBINAE; Pithecinae; and SAIMIRINAE. They inhabit the forests of South and Central America, comprising the largest family of South American monkeys.


MODS
Organ Failure, Multiple
Organ Dysfunction Syndrome, Multiple
Multiple Organ Dysfunction Syndrome
Multiple Organ Failure

A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.


Exchange, International Educational
Educational Exchange, International
International Educational Exchange

The exchange of students or professional personnel between countries done under the auspices of an organization for the purpose of further education.


Zeolites. A group of crystalline, hydrated alkali-aluminum silicates. They occur naturally in sedimentary and volcanic rocks, altered basalts, ores, and clay deposits. Some 40 known zeolite minerals and a great number of synthetic zeolites are available commercially. (From Merck Index, 11th ed)


A condition in which the death of adipose tissue results in neutral fats being split into fatty acids and glycerol.


Conservative Therapy
Conservative Treatment
Conservative Management

Therapeutic approaches that are limited, gradual, or well-established as opposed to radical methods.


Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.


Proinsulin Convertase 2
PC2 Protein
PC2 Endoprotease
Prohormone Convertase PC2
Prohormone Convertase, PC2
Prohormone Convertase 2
Neuroendocrine Convertase PC2
PC2 Prohormone Convertase
Endopeptidase PC2
Proprotein Convertase 2

A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.


Argininosuccinate Synthetase
Argininosuccinate Synthase

An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.


A plant genus of the family BUXACEAE that should not be confused with common spurge (EUPHORBIA).


EAAT-1 Excitatory Amino Acid Transporter

A glial type glutamate plasma membrane transporter protein found predominately in ASTROCYTES. It is also expressed in HEART and SKELETAL MUSCLE and in the PLACENTA.


A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.


Inflammatory Bowel Diseases
Bowel Diseases, Inflammatory

Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.


Injuries, Tooth
Injuries, Teeth
Tooth Injuries
Teeth Injuries

Traumatic or other damage to teeth including fractures (TOOTH FRACTURES) or displacements (TOOTH LUXATION).


Approximate, quantitative reasoning that is concerned with the linguistic ambiguity which exists in natural or synthetic language. At its core are variables such as good, bad, and young as well as modifiers such as more, less, and very. These ordinary terms represent fuzzy sets in a particular problem. Fuzzy logic plays a key role in many medical expert systems.


Data Banks as Topic
Databanks as Topic
Databases as Topic
Data Bases as Topic

Works on organized collections of records, standardized in format and content, that are stored in any of a variety of computer-readable modes.


Paracoccus denitrificans
Micrococcus denitrificans

A species of bacteria isolated from soil.


Kruppel-Like Transcription Factors
Kruppel-Like Factors

A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.


ATF3 Transcription Factor
Activating Transcription Factor 3
Activating Transcription Factor-3

An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.


BHA
(1,1-Dimethylethyl)-4-methoxyphenol
AMIF-72
Tenox BHA
Embanox
Butylated Hydroxyanisole
Nipantiox 1-F
Butylhydroxyanisole
Butyl Methoxyphenol

Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.


Mastocytosis
Mast-Cell Disease
Mast Cell Activation Syndromes
Mast Cell Disease
Mast Cell Activation Disease
Mast Cell Activation Syndrome

A heterogenous group of disorders characterized by the abnormal increase of MAST CELLS in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).


Sodium Channels, Voltage-Gated
Voltage-Gated Sodium Channels

A family of membrane proteins that selectively conduct SODIUM ions due to changes in the TRANSMEMBRANE POTENTIAL DIFFERENCE. They typically have a multimeric structure with a core alpha subunit that defines the sodium channel subtype and several beta subunits that modulate sodium channel activity.


An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.


Persian Gulf War, 1991
Gulf War
Operation Desert Storm
Operation Desert Shield

United Nations' action to intervene in conflict between the nation of Kuwait and occupying Iraqi forces, occurring from 1990 through 1991.


Chlamydophila Pneumonia
Chlamydial Pneumonia

Pneumonia caused by infections with the genus CHLAMYDIA; and CHLAMYDOPHILA, usually with CHLAMYDOPHILA PNEUMONIAE.


Mothers, Gestational
Mothers, Surrogate
Gestational Mothers
Surrogate Mothers
Host Mothers
Gestational Carriers

Women who allow themselves to be impregnated with the understanding that the offspring are to be given over to the parents who have commissioned the surrogate.


Ethylene Glycol Bis(2-aminoethyl ether)tetraacetic Acid

A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.


A polysaccharide extracted from Serratia marcescens and other bacteria. It activates enzymatic activity of macrophages and stimulates phagocytic processes.


Familial Multilocular Cystic Disease of the Jaws

Familial Benign Giant-Cell Tumor of the Jaw

A fibro-osseous hereditary disease of the jaws. The swollen jaws and raised eyes give a cherubic appearance; multiple radiolucencies are evident upon radiographic examination.


A protein present in the cell wall of most Staphylococcus aureus strains. The protein selectively binds to the Fc region of human normal and myeloma-derived IMMUNOGLOBULIN G. It elicits antibody activity and may cause hypersensitivity reactions due to histamine release; has also been used as cell surface antigen marker and in the clinical assessment of B lymphocyte function.


Extra-Embryonic Membranes
Fetal Membranes
Extraembryonic Membranes

Extra-embryonic tissues that contain the FETUS during PREGNANCY. They provide the support to accommodate FETAL DEVELOPMENT. Depending on the species, their structure and complexity vary greatly in the different forms of PLACENTA. These membranes undergo rupture during PARTURITION.


The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.


Polybromobiphenyl Compounds
Polybrominated Biphenyls

Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.


Microbial Inoculants
Agricultural Inoculants
Fungal Inoculants
Bacterial Inoculants

Beneficial microorganisms (bacteria or fungi) encapsulated in carrier material and applied to the environment for remediation and enhancement of agricultural productivity.


Calmette Guerin Bacillus Vaccine
Bacillus Calmette Guerin Vaccine
BCG Vaccine
Calmette's Vaccine

An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.


Cirrhosis, Experimental Liver
Liver Cirrhosis, Experimental
Experimental Liver Cirrhosis
Cirrhoses, Experimental Liver
Experimental Liver Cirrhoses
Liver Cirrhoses, Experimental
Hepatic Cirrhosis, Experimental

Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.


Occlusion, Balanced Dental
Balanced Dental Occlusion
Dental Occlusion, Balanced

Dental occlusion in which the occlusal contact of the teeth on the working side of the jaw is accompanied by the harmonious contact of the teeth on the opposite (balancing) side. (From Jablonski, Dictionary of Dentistry, 1992, p556)


A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)


Spinal Dysraphism
Schistorrhachis
Spinal Dysraphia
Open Spine
Status Dysraphicus
Spina Bifida
Rachischisis
Cleft Spine

Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)


Nuclear Antigens
Antigens, Nuclear
Extractable Nuclear Antigens

Immunologically detectable substances found in the CELL NUCLEUS.


Deoxyadenine Nucleotides
Deoxyadenosine Phosphates

Adenine nucleotides which contain deoxyribose as the sugar moiety.


Bridged-Ring Compounds
Bridged Compounds

Cyclic hydrocarbons that contain multiple rings which share one or more bridgehead connections.


A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion.


Tretinoin Potassium Salt
Vitamin A Acid
Tretinoin
beta-all-trans-Retinoic Acid
trans-Retinoic Acid
all-trans-Retinoic Acid
Retinoic Acid
Tretinoin Sodium Salt
Retin-A
Vesanoid
Tretinoin Zinc Salt

An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).


Non-Transmembrane Protein Tyrosine Phosphatases

Protein Tyrosine Phosphatases, Non-Receptor

A subcategory of protein tyrosine phosphatases that occur in the CYTOPLASM. Many of the proteins in this category play a role in intracellular signal transduction.


TFIIB
Transcription Factor TFIIB
Transcription Factor IIB

An RNA POLYMERASE II specific transcription factor. It plays a role in assembly of the pol II transcriptional preinitiation complex and has been implicated as a target of gene-specific transcriptional activators.


Clonal Selection Theory
Clonal Selection, Antigen-Mediated
Antigen-Mediated Clonal Selection

LYMPHOCYTE ACTIVATION by a specific ANTIGEN thus triggering clonal expansion of LYMPHOCYTES already capable of mounting an immune response to the antigen.


A dental specialty concerned with the histology, physiology, and pathology of the tissues that support, attach, and surround the teeth.


Upper Gastrointestinal Tract
Upper GI Tract

The segment of GASTROINTESTINAL TRACT that includes the ESOPHAGUS; the STOMACH; and the DUODENUM.


Protein Kinase CK1delta
Casein Kinase I delta
Casein Kinase Idelta
Casein Kinase 1 delta

A casein kinase I isoenzyme that plays a regulatory role in a variety of cellular functions including vesicular transport, CHROMOSOME SEGREGATION; CYTOKINESIS, developmental processes, and the CIRCADIAN RHYTHM.


Heart-Lung Transplantation
Transplantation, Heart-Lung
Grafting, Heart-Lung

The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.


Chemotaxis Inhibition
Cell Migration Inhibition

Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.


A combustible, gaseous mixture of low-molecular weight PARAFFIN hydrocarbons, generated below the surface of the earth. It contains mostly METHANE and ETHANE with small amounts of PROPANE; BUTANES; and higher hydrocarbons, and sometimes NITROGEN; CARBON DIOXIDE; HYDROGEN SULFIDE; and HELIUM. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


Phospholipase D
Lecithinase D
Phosphatidylcholine Phosphohydrolase

An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.


DCMP
Deoxycytidylic Acids
Deoxycytidine Monophosphate
Deoxycytidylic Acid

Deoxycytidine (dihydrogen phosphate). A deoxycytosine nucleotide containing one phosphate group esterified to the deoxyribose moiety in the 2'-,3'- or 5- positions.


Adult Survivors, Child Abuse
Child Abuse, Adult Survivors
Adult Survivors of Child Abuse

Persons who were child victims of violence and abuse including physical, sexual, or emotional maltreatment.


IgA, Exocrine
SIgA
Secretory IgA
Immunoglobulin A, Secretory
Secretory Immunoglobulin A
IgA, Secretory
Colostral IgA

The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).


Middle Cerebral Artery
Cerebral Artery, Middle

The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.


Cystatin E
Cystatin-6
Cystatin M
CST6 Cystatin

A cystatin subtype that has a diverse tissue distribution, target specificity, and functions as an endogenous inhibitor of lysosomal cysteine proteases.


Temporomandibular Disorders
TMJ Diseases
Temporomandibular Joint Disorders
TMJ Disorders
Temporomandibular Joint Diseases

A variety of conditions affecting the anatomic and functional characteristics of the temporomandibular joint. Factors contributing to the complexity of temporomandibular diseases are its relation to dentition and mastication and the symptomatic effects in other areas which account for referred pain to the joint and the difficulties in applying traditional diagnostic procedures to temporomandibular joint pathology where tissue is rarely obtained and x-rays are often inadequate or nonspecific. Common diseases are developmental abnormalities, trauma, subluxation, luxation, arthritis, and neoplasia. (From Thoma's Oral Pathology, 6th ed, pp577-600)


Cyclic-AMP-Dependent Protein Kinase RIbeta Subunit

Regulatory Subunit RIbeta, Cyclic-AMP-Dependent Protein Kinase

cAMP-Dependent Protein Kinase, Type 1beta-Regulatory Subunit

Cyclic AMP-Dependent Protein Kinase RIbeta Subunit

A type I cAMP-dependent protein kinase regulatory subunit that plays a role in confering CYCLIC AMP activation of protein kinase activity. It is found abundantly expressed in the neuronal tissue and may be associated with hippocampal function.


An aminohydrolase that catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. In most higher eucaryotic organisms this enzyme also includes METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP) and FORMATE-TETRAHYDROFOLATE LIGASE activities.


A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)


A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (Enzyme Nomenclature, 1992) EC 1.


The right of individuals to work, to free choice of employment, to just and favorable conditions of work and to protection against unemployment.


A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.


Activating Transcription Factor 2
CRE-Binding Protein 1
ATF2 Transcription Factor

An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.


Uridine Diphosphogalactose
Uridine Diphosphate Galactose
UDPGal
UDP Galactose
Uridine Pyrophosphogalactose

A nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides, and lactose.


Ectodermal Dysplasia, Anhidrotic, X-Linked

Anhidrotic Ectodermal Dysplasia, X-Linked

X-Linked Hypohydridic Ectodermal Dysplasia

Ectodermal Dysplasia, Hypohydridic, X-Linked

Anhydrotic Ectodermal Dysplasia, X-Linked

Ectodermal Dysplasia, Hypohidrotic, X-Linked

An X-linked form of ectodermal dysplasia which results from mutations of the gene encoding ECTODYSPLASIN.


Trypanosoma gambiense
Trypanosoma brucei gambiense

A hemoflagellate subspecies of parasitic protozoa that causes Gambian or West African sleeping sickness in humans. The vector host is usually the tsetse fly (Glossina).


Hypoxic conditions in tumor cells due to the tumor outgrowing its blood supply. It is associated with increased METASTASIS and resistance to RADIOTHERAPY and DRUG THERAPY.


Scrapie PrP 27-30 Protein
Fibrils, Scrapie-Associated
Scrapie-Associated Fibril-Protein
Scrapie Associated Fibril-Protein
PrP 27-30 Protein
Fibril-Protein, Scrapie-Associated
Scrapie-Associated Fibrils

Protease-resistant core of PrPSc, the abnormal isoform of PRION PROTEINS. PrP 27-30 is produced by limited proteolysis of the N-terminus of PrPSc.


Nucleotide-sugars such as uridine-diphosphate glucose or UDP-glucose.


Human Centered Design
Design for All
Universal Design

The design of products and environments to be usable by all people, to the greatest extent possible, without the need for adaption or specialized design.


Social Identification
Social Identity
Identification, Social
Group Identification

The process by which an aspect of self image is developed based on in-group preference or ethnocentrism and a perception of belonging to a social or cultural group. (From APA, Thesaurus of Psychological Index Terms, 8th ed.)


Protein Tyrosine Phosphatases, Receptor-Like

Receptor-Like Protein Tyrosine Phosphatases

A subcategory of protein tyrosine phosphatases that are bound to the cell membrane. They contain cytoplasmic tyrosine phosphatase domains and extracellular protein domains that may play a role in cell-cell interactions by interacting with EXTRACELLULAR MATRIX components. They are considered receptor-like proteins in that they appear to lack specific ligands.


Proto-Oncogene Protein Wnt-1
Wnt1 Protein
Wnt-1 Protein
c-int Protein
Proto-Oncogene Protein Int-1
Wnt1 Proto-Oncogene Protein

A proto-oncogene protein and member of the Wnt family of proteins. It is expressed in the caudal MIDBRAIN and is essential for proper development of the entire mid-/hindbrain region.


A non-metabolizable glucose analogue that is not phosphorylated by hexokinase. 3-O-Methylglucose is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems. (J Neurochem 1993;60(4):1498-504)


Acetyl Coenzyme A Carboxylase
Acetyl-CoA Carboxylase

A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.


Viral Proteins
Gene Products, Viral
Viral Gene Products
Viral Gene Proteins


Parencephalon
Corpus Cerebelli
Cerebellum

The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.


Tarsal Tunnel Syndrome
Posterior Tibial Nerve Neuralgia
Tarsal Tunnel Entrapment Neuropathy
Entrapment Neuropathy, Tarsal Tunnel
Tarsal Tunnel Tibial Neuropathy
Tibial Neuropathy, Tarsal Tunnel

Entrapment of the distal branches of the posterior TIBIAL NERVE (which divides into the medial plantar, lateral plantar, and calcanial nerves) in the tarsal tunnel, which lies posterior to the internal malleolus and beneath the retinaculum of the flexor muscles of the foot. Symptoms include ankle pain radiating into the foot which tends to be aggravated by walking. Examination may reveal Tinel's sign (radiating pain following nerve percussion) over the tibial nerve at the ankle, weakness and atrophy of the small foot muscles, or loss of sensation in the foot. (From Foot Ankle 1990;11(1):47-52)


Granuloma Venereum
Donovanosis
Granuloma Inguinale

Anogenital ulcers caused by Calymmatobacterium granulomatis as distinguished from lymphogranuloma inguinale (see LYMPHOGRANULOMA VENEREUM) caused by CHLAMYDIA TRACHOMATIS. Diagnosis is made by demonstration of typical intracellular Donovan bodies in crushed-tissue smears.


Calcification of Posterior Longitudinal Ligament

Ossification of Posterior Longitudinal Ligament

Posterior Longitudinal Ligament Calcification

Posterior Longitudinal Ligament Ossification

A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. It is often associated with anterior ankylosing hyperostosis.


Dermatitis Exfoliative
Erythroderma
Dermatitis Exfoliative Generalised
Dermatitis Exfoliative Generalized
Dermatitis, Exfoliative
Dermatitis Exfoliativa

The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)


gamma-Endorphin
beta-Endorphin (1-17)
Endorphin, gamma

An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 17-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from ALPHA-ENDORPHIN by one amino acid (beta-endorphin 1-16).


Complement Pathway, Mannose-Binding Lectin

Mannan-Binding Lectin Pathway (Complement Activation)

Mannose-Binding Lectin Complement Pathway

Mannan-Binding Lectin Complement Pathway

Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.


A technique in which electric pulses of intensity in kilovolts per centimeter and of microsecond-to-millisecond duration cause a temporary loss of the semipermeability of CELL MEMBRANES, thus leading to ion leakage, escape of metabolites, and increased uptake by cells of drugs, molecular probes, and DNA.


Radiographic Tomography
Tomography, X Ray
Xray Tomography
Tomography, Transmission
Transmission Tomography
X-Ray Tomography
Tomography, Radiographic
Tomography, Xray
Zonography
Tomography, X-Ray
X Ray Tomography


Injuries, Ankle
Syndesmotic Injuries
Ankle Injuries
Ankle Sprains

Harm or hurt to the ankle or ankle joint usually inflicted by an external source.


Lymphomatoid Granulomatosis
Granulomatosis, Lymphomatoid

An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.


Nagana
African Sleeping Sickness
African Trypanosomiasis
Trypanosomiasis, African

A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.


Tamus communis
Black Bryony
Tamus
Bryony, Black

A plant genus of the DIOSCOREACEAE plant family.


Deficiency, Factor Five
Deficiency, Factor V
Owren Parahemophilia
Owren's Disease
Parahemophilia
Factor Five Deficiency
Labile Factor Deficiency
Deficiency, Factor 5
Factor 5 Deficiency
Factor V Deficiency
Owren Disease

A deficiency of blood coagulation factor V (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren's disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait. (Dorland, 27th ed)


Circulatory System
Cardiovascular System

The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.


The use of focused, high-frequency sound waves to produce local hyperthermia in certain diseased or injured parts of the body or to destroy the diseased tissue.


Serotonin 5-HT4 Receptor Antagonists
5-HT4 Antagonist
5-HT4 Antagonists

Drugs that bind to but do not activate SEROTONIN 5-HT4 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN RECEPTOR AGONISTS.


Gamma Motorneurons
Neurons, Fusimotor
Motor Neurons, Gamma
Motor Neurons, Gamma-Efferent
Neurons, Gamma Motor

Motor neurons which activate the contractile regions of intrafusal SKELETAL MUSCLE FIBERS, thus adjusting the sensitivity of the MUSCLE SPINDLES to stretch. Gamma motor neurons may be "static" or "dynamic" according to which aspect of responsiveness (or which fiber types) they regulate. The alpha and gamma motor neurons are often activated together (alpha gamma coactivation) which allows the spindles to contribute to the control of movement trajectories despite changes in muscle length.


Friend Leukemia Integration 1 Transcription Factor

Retroviral Integration Site Protein Fli-1

A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS.


Small Inducible Cytokine Subfamily B, Member 11 Protein

A CXC chemokine that is induced by GAMMA-INTERFERON. It is a chemotactic factor for activated T-LYMPHOCYTES and has specificity for the CXCR3 RECEPTOR.


Ethanolamine Ammonia-Lyase
Ethanolamine Deaminase

An enzyme that catalyzes the deamination of ethanolamine to acetaldehyde. EC 4.3.1.7.


Nonachlazine Nonachlazin Azaclorzine Nonakhlazin

Coronary vasodilator with a novel mechanism of action; proposed as antianginal agent.


Deoxyribonucleases, Type III, Site Specific

Type III Site Specific Deoxyribonucleases

Deoxyribonucleases, Type III Site-Specific

Type III Site-Specific Deoxyribonucleases

Deoxyribonucleases, Type III, Site-Specific

Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as ATPases. They exist as complexes with modification methylases of similar specificity listed under EC 2.1.1.72 or EC 2.1.1.73. The systems recognize specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.5.


The level of governmental organization and function at the national or country-wide level.


Complement C9
C9 Complement
Complement 9
Complement Component 9

A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.


Poly U
Polyuridylic Acids
Poly(rU)
Uracil Polynucleotides

A group of uridine ribonucleotides in which the phosphate residues of each uridine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.


DNA, Superhelical
DNA, Supertwisted
DNA, Supercoiled

Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.


DT Diaphorase
Phylloquinone Reductase
Vitamin K Reductase
Menadione Reductase
NAD(P)H Dehydrogenase (Quinone)
Quinone Reductase

A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.


Pyrimidine Nucleoside Phosphorylase
Pyrimidine Phosphorylases

Pentosyltransferases that catalyze the reaction between a pyrimidine nucleoside and orthophosphate to form a free pyrimidine and ribose-5-phosphate.


Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.


Nucleoside Monophosphate Kinases
Nucleoside-Phosphate Kinase

An enzyme that catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside monophosphate, e.g., UMP, to form ADP and UDP. Many nucleoside monophosphates can act as acceptor while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC 2.7.4.4.


Neethling Virus
Lumpy skin disease virus

A species of CAPRIPOXVIRUS causing a cattle disease occurring in Africa.


A compound tubular gland, located around the eyes and nasal passages in marine animals and birds, the physiology of which figures in water-electrolyte balance. The Pekin duck serves as a common research animal in salt gland studies. A rectal gland or rectal salt gland in the dogfish shark is attached at the junction of the intestine and cloaca and aids the kidneys in removing excess salts from the blood. (Storer, Usinger, Stebbins & Nybakken: General Zoology, 6th ed, p658)


Adjustment, Social
Adjustment
Social Adjustment

Adaptation of the person to the social environment. Adjustment may take place by adapting the self to the environment or by changing the environment. (From Campbell, Psychiatric Dictionary, 1996)


Specificity Protein 3 Transcription Factor

A specificity protein transcription factor that contains three C-terminal CYS2-HIS2 ZINC FINGERS. It regulates expression of a variety of genes including VASCULAR ENDOTHELIAL GROWTH FACTOR and CYCLIN-DEPENDENT KINASE INHIBITOR P27.


Digestive System and Oral Physiological Phenomena

Digestive System and Oral Physiological Concepts

Digestive System and Oral Physiological Phenomenon

Properties and processes of the DIGESTIVE SYSTEM and DENTITION as a whole or of any of its parts.


Team Science
Interdisciplinary Research
Transdisciplinary Research
Multidisciplinary Research

Collaborative effort to address a scientific challenge that leverages the strengths and expertise of professionals trained in different fields. It encompasses both conceptual and methodological strategies aimed at understanding and enhancing the processes and outcomes of collaborative, team-based research. (from https://www.teamsciencetoolkit.cancer.gov/Public/WhatIsTS.aspx)


A plant genus of the family MYOPORACEAE. Members contain dehydrongaione, deisopropylngaione, dehydromyodesmone and other furanoid sesquiterpene essential oils. It is the source of Ngaio oil and ngaione.


White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.


Vesicular Integral Membrane Protein 21 kDa

A tyrosine phosphoprotein that plays an essential role in CAVEOLAE formation. It binds CHOLESTEROL and is involved in LIPIDS transport, membrane traffic, and SIGNAL TRANSDUCTION.


Mesulam Syndrome
Mesulam's Syndrome
Aphasia, Primary Progressive

A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)


Generalization, Psychological
Generalization, Psychology
Generalization (Psychology)

The phenomenon of an organism's responding to all situations similar to one in which it has been conditioned.


The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the PATELLA; TIBIA; and FIBULA.


Transplantation, Autologous
Autotransplantation
Autografting
Autologous Transplantation

Transplantation of an individual's own tissue from one site to another site.


Restriction-Modification Systems
Restriction Modification Systems
DNA Restriction Modification Enzymes
DNA Restriction-Modification Enzymes

Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.


An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.


Drugs formulations that do not meet established standards.


Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of MERCURY or MERCURY COMPOUNDS.


A genus, commonly called budgerigars, in the family PSITTACIDAE. In the United States they are considered one of the five species of PARAKEETS.


Starch Synthase
ADP Glucose Starch Glucosyltransferase
Starch (Bacterial Glycogen) Synthase
GBSS
Granule-Bound Starch Synthase

An enzyme that catalyzes the transfer of glucose from ADPglucose to glucose-containing polysaccharides in 1,4-alpha-linkages. EC 2.4.1.21.


Diazacholesterol Dihydrochloride
SC 12937
20,25-Diazacholesterol
Azacosterol

Diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase, which causes the accumulation of desmosterol.


Cardiovascular Pregnancy Complications
Pregnancy Complications, Cardiovascular
Pregnancy, Cardiovascular Complications
Complications, Cardiovascular Pregnancy

The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.


Insulin-Like Growth Factor Binding Protein 2

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.


Glycyl T RNA Synthetase
Gly-tRNA Ligase
Glycine-tRNA Ligase
Glycyl-tRNA Synthetase

An enzyme that activates glycine with its specific transfer RNA. EC 6.1.1.14.


Bifidobacterium longum subspecies infantis

A subspecies of Bifidobacterium longum that occurs in the GASTROINTESTINAL TRACT of human infants and is used as a PROBIOTIC. It may also be used in the treatment of IRRITABLE BOWEL SYNDROME.


Oxoprolinase
5-Oxoprolinase
Pyroglutamate Hydrolase

Hydrolyzes pyroglutamic acid in the presence of ATP to glutamate plus ADP and inorganic phosphate. Deficiency leads to pyroglutamic acidurea.


A plant genus of the family FABACEAE that is a source of SPARTEINE, lupanine and other lupin alkaloids.


FOXL2 Protein
Forkhead Box L2 Protein
Forkhead Box Protein L2

A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).


Glossopharyngeal Nerve
Cranial Nerve IX
Ninth Cranial Nerve

The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and CHEMORECEPTOR CELLS of the carotid sinus.


Fusion Regulatory Protein-2
CD49c Antigen
Antigens, CD49c
alpha(3) Integrin
CD49c Antigens
Integrin alpha3
FRP-2

An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.


Transferases (Other Substituted Phosphate Groups)

Phosphotransferases (Other Substituted Phosphate Groups)

A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.


Genetic Introgression
Introgressive Hybridization

The transfer of genetic material from one species to another by inter-species hybridization and repeated backcrossing.


Lentiviruses, Bovine
Bovine Lentiviruses

A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in cattle.


Planned Parenthood Federation of America

International Planned Parenthood Federation

A non-profit organization concerned with providing access to sexual and reproductive health information and services.


Chondroitin Sulfate Proteoglycan Core Protein 2

HYALURONAN-containing proteoglycans found in the EXTRACELLULAR MATRIX of a variety of tissues and organs. Several versican isoforms exist due to multiple ALTERNATIVE SPLICING of the versican MESSENGER RNA.


Body Buffer Zone
Peripersonal Space
Privacy of Space
Personal Space

Invisible boundaries surrounding the individual's body which are maintained in relation to others.


Fibroepithelial Neoplasms
Neoplasms, Fibroepithelial

Neoplasms composed of fibrous and epithelial tissue. The concept does not refer to neoplasms located in fibrous tissue or epithelium.


Vibrio Infections
Infections, Vibrio
Vibriosis
Vibrio Illness

Infections with bacteria of the genus VIBRIO.


Microscopy, Video
Videomicroscopy
Video Microscopy
Videomicrography

Microscopy in which television cameras are used to brighten magnified images that are otherwise too dark to be seen with the naked eye. It is used frequently in TELEPATHOLOGY.


Analysis, Differential Thermal
Thermal Analysis, Differential
Differential Thermal Analysis

Technique by which phase transitions of chemical reactions can be followed by observation of the heat absorbed or liberated.


Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA.


Neovascularization, Physiologic
Angiogenesis, Physiological
Neovascularization, Physiological
Angiogenesis, Physiologic
Physiologic Neovascularization
Physiologic Angiogenesis

The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.


Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.


Fuchs Atrophy
Fuchs' Endothelial Dystrophy
Fuch's Endothelial Dystrophy
Fuchs Dystrophy
Fuchs Endothelial Dystrophy
Fuchs Endothelial Corneal Dystrophy
Fuchs Corneal Dystrophy

Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.


SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase

SAM Domain and HD Domain-Containing Protein 1

A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).


Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.


Gram-Positive Bacterial Infections
Bacterial Infections, Gram-Positive
Infections, Gram-Positive Bacterial

Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.


Membrane-Type Matrix Metalloproteinase 3

Membrane-Type 3 Matrix Metalloproteinase

A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the proteolytic action of PROPROTEIN CONVERTASES. Matrix metalloproteinase 16 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of other MATRIX METALLOPROTEINASES such as the zymogen of MATRIX METALLOPROTEINASE 2.


Superior Vena Cava Thrombosis
Superior Vena Cava Obstruction
Superior Vena Cava Syndrome

A condition that occurs when the obstruction of the thin-walled SUPERIOR VENA CAVA interrupts blood flow from the head, upper extremities, and thorax to the RIGHT ATRIUM. Obstruction can be caused by NEOPLASMS; THROMBOSIS; ANEURYSM; or external compression. The syndrome is characterized by swelling and/or CYANOSIS of the face, neck, and upper arms.


Insulin, Short-Acting
Insulin, Rapid-Acting

Insulin derivatives and preparations that are designed to induce a rapid HYPOGLYCEMIC EFFECT.


Lipedema with secondary LYMPHEDEMA involvement.


Physicians, Primary Care
Primary Care Physicians

Providers of initial care for patients. These PHYSICIANS refer patients when appropriate for secondary or specialist care.


A plant genus of the family SANTALACEAE which is the source of sandalwood oil.


A plant genus of the family Lamiaceae used in folk medicine.


Services, Suburban Health
Health Services, Suburban
Suburban Health Services

Health services, public or private, in suburban areas. The services include the promotion of health and the delivery of health care.


Surgical procedure to remove one or both breasts.


A group of lymphocyte surface antigens located on mouse LYMPHOCYTES. Specific Ly antigens are useful markers for distinguishing subpopulations of lymphocytes.


Upper Extremity Deformities, Congenital
Upper Limb Deformities, Congenital

Congenital structural abnormalities of the UPPER EXTREMITY.


Schizophrenia, Paranoid
Paranoid Schizophrenia
Delusional Disorder

Disorder with presentation of a facade of coldness with characteristic pervasive mistrust and suspiciousness of others.


Technetium Tc 99m Diethylacetanitanildo-IDA

Technetium Tc 99m Diethyl-iminodiacetic Acid

A nontoxic radiopharmaceutical that is used in the clinical evaluation of hepatobiliary disorders in humans.


Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.


A syndrome characterized by recurring fever, rash, and arthralgias occurring days to weeks after a rat bite. The causative agents are either Streptobacillus moniliformis or Spirillum minus.


Epidemiologic Studies
Studies, Epidemiologic
Epidemiological Studies

Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.


Manufacturing Industry
Fabrication Industry

An INDUSTRY which specializes in the fabrication or manufacture of products from raw or intermediate materials.


Heart Valve Diseases
Valvular Heart Diseases

Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).


Crura Cerebri
Crus Cerebri
Cerebral Crus
Cerebral Crura

Anterior portion of the cerebral peduncle which contains the motor tracts.


An experimental LYMPHOCYTIC LEUKEMIA of mice.


Brachium Pontis
Middle Cerebellar Peduncle
Brachia Pontis

WHITE MATTER consisting of a large bundle of paired fibers originating in the pontine nuclei in the pre pontis and the nucleus reticularis tegmenti pontis projecting to the contralateral cerebral cortex.


Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.


Emergency Medical Tags
Tag, Emergency Medical
Medical Tags, Emergency
Tags, Emergency Medical
Medical Tag, Emergency
Emergency Medical Tag

A bracelet or necklace worn by an individual that alerts emergency personnel of medical information for that individual which could affect their condition or treatment.


Receptors, Vasoactive Intestinal Peptide

Cell surface proteins that bind VASOACTIVE INTESTINAL PEPTIDE; (VIP); with high affinity and trigger intracellular changes which influence the behavior of cells.


Aniline Yellow
para-Aminoazobenzene
4-(Phenyldiazenyl)aniline
p-Aminoazobenzene
C.I. Solvent Yellow 1

Used in the form of its salts as a dye and as an intermediate in manufacture of Acid Yellow, diazo dyes, and indulines.


Factor 10 Deficiency
Deficiency, Factor X
Deficiency, Stuart-Prower Factor
Factor Ten Deficiency
Deficiency, Stuart-Prower
Factor X Deficiency
Stuart-Prower Factor Deficiency
Stuart-Prower Deficiency
Deficiency, Factor Ten
Deficiency, Factor 10

Blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.


Malocclusion, Angle Class III
Prognathism, Mandibular
Underbite
Angle Class III
Hapsburg Jaw
Habsburg Jaw

Malocclusion in which the mandible is anterior to the maxilla as reflected by the first relationship of the first permanent molar (mesioclusion).


Human Leukocyte Antigens
HLA Antigens
HL-A Antigens
Leukocyte Antigens

Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.


The state of legal insolvency with assets taken over by judicial process so that they may be distributed among creditors.


Fra-2 Transcription Factor
Fos-Related Antigen-2

A basic-leucine zipper transcription factor that is closely related to C-FOS PROTEINS. It forms heterodimeric complexes with C-JUN PROTEINS to regulate GENE transcription.


Poke Plant
Phytolacca americana
Pokeweed

A plant species of the family PHYTOLACCACEAE. The root has been used in traditional medicine and contains POKEWEED MITOGENS, triterpene glycosides, and antiviral protein.


Receptor Antagonists, Histamine H2
Antihistaminics, H2
Blockaders, Histamine H2 Receptor
Antagonists, Histamine H2
Receptor Blockaders, H2
H2 Receptor Blockaders
Histamine H2 Receptor Blockaders
Histamine H2 Antagonists
Histamine H2 Receptor Antagonists
Histamine H2 Blockers

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.


17-Hydroxyprogesterone, (9 beta, 10 alpha)-Isomer

A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.


A DNA repair pathway involved in correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. Excinucleases recognize the BASE PAIR MISMATCH and cause a segment of polynucleotide chain to be excised from the daughter strand, thereby removing the mismatched base. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)


c-sis Proteins
sis Proto-Oncogene Proteins
Platelet-Derived Growth Factor B
PDGFB
Proto-Oncogene Products c-sis
Proto-Oncogene Proteins sis
Proto-Oncogene Proteins c-sis
Proto-Oncogene Protein sis

Cellular DNA-binding proteins encoded by the sis gene (GENES, SIS). c-sis proteins make up the B chain of PLATELET-DERIVED GROWTH FACTOR. Overexpression of c-sis causes tumorigenesis.