Benchmarking
Benchmarking, Healthcare
Benchmarking, Health Care
Best Practice Analysis
Metrics
Benchmarks
Benchmark

Method of measuring performance against established standards of best practice.


Papilledema Associated with Decreased Intraocular Pressure

Decreased Intraocular Pressure-Associated Papilledema

Papilledema Associated with Increased Intracranial Pressure

Increased Intracranial Pressure-Associated Papilledema

Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)


Thrombosis, Cavernous Sinus
Caverous Sinus Septic Phlebitis
Cavernous Sinus, Phlebitis, Septic
Phlebitis, Cavernous Sinus, Septic
Cavernous Sinus Thrombosis
Cavernous Sinus Thrombophlebitis
Septic Phlebitis, Cavernous Sinus

Formation or presence of a blood clot (THROMBUS) in the CAVERNOUS SINUS of the brain. Infections of the paranasal sinuses and adjacent structures, CRANIOCEREBRAL TRAUMA, and THROMBOPHILIA are associated conditions. Clinical manifestations include dysfunction of cranial nerves III, IV, V, and VI, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)


Blot, Northern
Blotting, Northern
Northern Blot
Northern Blotting

Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.


A phthalimide and piperidone derivative that has immunomodulatory and antiangiogenic properties. It is used for the treatment of transfusion-dependent anemia in MYELODYSPLASTIC SYNDROMES, and for the treatment of MULTIPLE MYELOMA, and relapsed or refractory MANTLE CELL LYMPHOMA.


Metadate
Phenidylate
Methylphenidate
Daytrana
Concerta
Ritalin
Centedrin
Equasym
Ritalin-SR
Tsentedrin
Ritaline
Methylin
Methylphenidate Hydrochloride

A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.


Pathology, Language
Speech Pathology
Pathology, Speech
Language Pathology
Speech-Language Pathology
Pathology, Speech-Language

The study of speech or language disorders and their diagnosis and correction.


Hemophagocytic Lymphohistiocytosis Familial -1

Hemophagocytic Lymphohistiocytosis, Familial, 1

Proliferation of HISTIOCYTES in response to viral, bacterial, fungal, or parasitic infections.


Primary Empty Sella Syndrome
Empty Sella Turcica
Secondary Empty Sella Syndrome
Empty Sella Syndrome, Primary
Empty Sella Turcica Syndrome
Empty Sella Syndrome, Secondary
Empty Sella Syndrome

A condition when the SELLA TURCICA is not filled with pituitary tissue. The pituitary gland is either compressed, atrophied, or removed. There are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of PITUITARY NEOPLASMS.


Molindone Monohydrochloride
Molindone
Moban
Molindone Hydrochloride

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)


Myelitis, Acute Transverse
Demyelinative Myelitis
Postinfectious Myelitis
Myelitis, Subacute Transverse
Transverse Myelitis
Transverse Myelopathy Syndrome
Myelitis, Necrotizing
Myelitis, Postvaccinal
Myelitis, Postinfectious
Myelitis, Transverse
Myelitis, Paraneoplastic

Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)


Cefobid
Cefoperazone
T1551
Céfobis
Cefoperazone Sodium Salt
Cefoperazon
T-1551
Cefoperazone Sodium

Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections.


Genetic Screening
Genetic Predisposition Testing
Predictive Testing, Genetic
Predictive Genetic Testing
Testing, Genetic Predisposition
Genetic Testing

Searching a population or individuals for persons possessing any of a set of certain gene mutations, genotypes, or karyotypes that: (1) are already associated with disease or predispose to disease; (2) may lead to disease in their descendants; or (3) produce other variations not known to be associated with disease. Genetic screening may be directed toward identifying phenotypic expression of genetic traits. It includes prenatal genetic screening.


Endocrine Disruptor Effects
Endocrine Disruptors
Endocrine Disruptor Effect
Endocrine Disrupting Chemicals

Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.


Anacardiaceae
Peppertree, California
Lannea
Lithrea
Marula
Cotinus
Spondias
Peppertree, Brazilian
Schinus
Sclerocarya

A plant genus of the family ANACARDIACEAE.


Infarct, Lacunar
Stroke, Lacunar
Infarction, Lacunar
Lacunar Syndrome

Brain infarction that affects small subcortical vessels due to occlusion of a penetrating artery deep in the brain. It may lead to lacunar stroke.


A plant genus of the family FABACEAE. It is the source of an herbal tea that is commonly consumed in South Africa. Members contain aspalathin and other polyphenols (PHENOLS).


Benign Recurrent Abducens Palsy, Children

Benign Recurrent Abducens Palsy of Childhood

Abducens Palsy, Childhood, Benign Recurrent

Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.


Syringofibroadenoma
Syringoacanthoma
Eccrine Poroma
Apocrine Poroma
Poroma
Poromatosis
Hidracanthoma Simplex
Dermal Duct Tumor
Intraepidermal Poroma

Benign adnexal neoplasm whose glandular secretion includes the release of part of the secreting cell.


Oriental Medicine, Traditional
Traditional East Asian Medicine
East Asian Traditional Medicine
Medicine, Oriental Traditional
Medicine, Oriental
Traditional Medicine, East Asia
Medicine, Traditional, East Asia
Traditional Far Eastern Medicine
East Asian Medicine
Medicine, Far East
Medicine, East Asia
Medicine, East Asian Traditional
Oriental Medicine
Traditional Medicine, Oriental
Oriental Traditional Medicine

Medical practice or discipline that is based on the knowledge, cultures, and beliefs of the people in EAST ASIA.


PhyA Phytochrome
Phytochrome A4
PhyA3 Protein
Phytochrome A4 Protein
Phytochrome A Protein
PhyA4 Protein
Phytochrome A
Phytochrome A3 Protein
Phytochrome A3

The primary plant photoreceptor responsible for perceiving and mediating responses to far-red light. It is a PROTEIN-SERINE-THREONINE KINASE that is translocated to the CELL NUCLEUS in response to light signals.


Liberian Mongoose
Herpestidae
Herpestes
Cusimanses
Helogale
Mungos
Mongooses
Liberiictis
Crossarchus
Dwarf Mongooses

The family of agile, keen-sighted mongooses of Asia and Africa that feed on RODENTS and SNAKES.


Determination, Sequence
Determinations, Sequence
Sequence Determinations
Analysis, Sequence
Sequence Determination
Sequence Analysis

A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.


Acquired Agraphia
Dysgraphia
Acquired Dysgraphia
Developmental Agraphia
Pure Agraphia
Agraphia
Developmental Dysgraphia
Constructional Agraphia

Some authorities use this term interchangeably with Agraphia and some do not.


Dentists
Dentists, Prosthetic
Periodontists
Dentists, Pediatric
Dentists, Restorative
Prosthodontists

Dentists specializing in the prevention, diagnosis, and treatment of PERIODONTAL DISEASES and in the placement of DENTAL IMPLANTS.


Tipped Uterus
Retroflexed Uterus
Retroverted Gravid Uterus
Incarcerated Retroverted Uterus
Uterine Retroflexion
Retroverted Uterus
Uterine Retroversion

A retroverted UTERUS entrapped in the pelvis.


Group Therapy
Group Psychotherapy
Psychotherapy, Group
Therapy, Group

A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.


Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer

Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.


Lipomin
Modératan
Phepranon
Préfamone
Diethylpropion
Neobes
Regibon
Dietil-retard
Delgamer
Amfepramone
Amfepramon
Nobesine
Tepanil
Regenon
Ifa Norex
Propion
Maruate
2-Diethylaminopropiophenone
Diethylpropion Hydrochloride
Tenuate
Anorex

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)


Peptide T20
T20 Peptide
DP178
Pentafuside
DP 178
Enfuvirtide
DP-178
Fuzeon

A synthetic 36-amino acid peptide that corresponds to the heptad repeat sequence of HIV-1 gp41. It blocks HIV cell fusion and viral entry and is used with other anti-retrovirals for combination therapy of HIV INFECTIONS and AIDS.


Pre-B-Cells
Immature B-Lymphocytes
Pro-B Cells
Pro-B Lymphocytes
Transitional B-Lymphocytes
Precursor Cells, B-Lymphoid
Precursor B-Cells
Precursor B-Lymphocytes
B-Lymphoid Precursor Cells
Pro-B-Cells
Immature B-Cells
Pre-B Lymphocytes
Progenitor B-Cells
Progenitor B-Lymphocytes
Transitional B-Cells
Pre-B Cells

Cells from the stage of B LYMPHOCYTE development where B-CELL GENE REARRANGEMENT begins. The pro-B cell stage is followed by the pre-B cell stage.


Primary Central Nervous System Vasculitis

Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)


Ictalurivirus
Ictalurid herpesvirus 1
Channel Catfish Virus

An unassigned genus in the family HERPESVIRIDAE, comprising one species Ictalurid herpesvirus 1 (Channel Catfish Virus).


Polypro
Hostalen
Polypropylenes
Polypropylene
Prolene
Propylene Polymers
Propene Polymers
Marlex Polypropylene
Marlex

Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.


An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.


Erythrocyte Cytoskeleton
Erythrocyte Membrane
Erythrocyte Ghost
Red Cell Ghost

The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.


Fasciolar Gyrus
Grande Lobe Limbique of Broca
Paraterminal Gyrus
Supracallosal Gyrus
Limbic Lobe
Lobus Limbicus
Indusium Griseum
Subcallosal Gyrus

The medial surface of the cerebral hemisphere around the brain stem.


Immunonephelometry
Immunonephelometric Assay
Immunoturbidimetry
Turbidimetric Immunoassay
Immunoturbidimetric Assay

Immunochemical analysis which measures specific target antigen bound to antibody complex. Antibodies in assay form insoluble light scattering immune-aggregates which cause changes in the measured turbidity proportional to the concentration of the antigen.


Restrictive Diet Therapy
Diet Modification
Restriction Diet Therapies
Diet Therapy
Therapy, Diet
Diet Therapy, Restrictive
Dietary Modification
Restrictive Diet Therapies
Restriction Diet Therapy

Adjusting the quantity and quality of food intake to improve health status of an individual. This term does not include the methods of food intake (NUTRITIONAL SUPPORT).


B-Cell Leukemia 2 Family Proteins
c-bcl-2 Proteins
bcl-2 Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
BCL2 Family Proteins
BCL2 Proteins

Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.


Statistics, Service
Estimation Techniques
Statistical Study
Multiple Classification Analysis
Indirect Estimation Techniques
Area Analysis
Tables and Charts as Topic
Service Statistics
Statistics as Topic
Indirect Estimation Technics
Estimation Technics

Works about the science and art of collecting, summarizing, and analyzing data that are subject to random variation.


Committee, Pharmacy
Committee, Formulary
Committee, Therapeutics
Pharmacy Committee
Committees, Formulary
Therapeutics Committee
Pharmacy Committees
Committees, Therapeutics
Drug Committee
Committees, Drug
Therapeutics Committees
Pharmacy and Therapeutics Committee
Committee, Drug
Formulary Committee
Drug Committees
Committees, Pharmacy
Formulary Committees

An advisory group composed primarily of staff physicians and the pharmacist which serves as the communication link between the medical staff and the pharmacy department.


N-Acetylhomotaurine, Magnesium (2:1) Salt

Structural analog of taurine that is used for the prevention of relapse in individuals with ALCOHOLISM.


Acute Inflammatory Demyelinating Polyradiculoneuropathy

Polyradiculoneuropathy, Acute Inflammatory Demyelinating

Inflammatory Demyelinating Polyradiculoneuropathy, Acute

Demyelinating Polyradiculoneuropathy, Acute Inflammatory

Polyneuropathy, Inflammatory Demyelinating, Acute

Acute Inflammatory Demyelinating Polyneuropathy

An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)


The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)


Post and Core Technic
Dental Dowel
Post and Core Technique
Dowels, Dental
Post Technique
Post Technic
Post-Core Technic
Dowel, Dental
Dental Dowels

Use of a metal casting, usually with a post in the pulp or root canal, designed to support and retain an artificial crown.


Activator 1 Protein, 40 kDa Subunit
Replication Factor C, Subunit 1
Activator 1 Protein, 145 kDa Subunit
Replication Factor C, Subunit 5
Replication Factor C, Subunit 4
Replication Protein C, Subunit 5
Replication Protein C, Subunit 4
Replication Protein C, Subunit 1
Replication Protein C
Replication Protein C, Subunit 3
Activator 1 p40
Replication Protein C, Subunit 2
Activator 1 Protein, 38 kDa Subunit
Replication Factor C, Subunit 3
Activator 1 Protein
Replication Factor C
Activator 1 Protein, 37 kDa Subunit
Replication Factor C, Subunit 2
Activator 1 Protein, 36 kDa Subunit

A DNA-binding protein and AAA ATPase that consists of 5 polypeptides and plays an essential role in DNA REPLICATION in eukaryotes. It binds DNA PRIMER-template junctions and recruits PROLIFERATING CELL NUCLEAR ANTIGEN and DNA POLYMERASES to the site of DNA synthesis.


Pituitary Growth Hormone-Secreting Adenoma

Pituitary Adenoma, Growth Hormone-Secreting

Growth Hormone-Secreting Pituitary Adenoma

A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.


Serpulina
Treponema innocens
Brachyspira innocens
Serpulina innocens
Brachyspira
Serpula innocens

A genus of spiral bacteria of the family Brachyspiraceae.


Coxsackieviruses
Coxsackie Viruses
Enterovirus

Heterogeneous serotypes of various species in the genus ENTEROVIRUS, found in association with various diseases in man and other animals. The specific coxsackieviruses are distributed among the species HUMAN ENTEROVIRUS A; HUMAN ENTEROVIRUS B; and HUMAN ENTEROVIRUS C. The name is derived from a village in New York State where the virus was first identified.


Anion Exchangers (Proteins)
Anion Exchange Proteins
Antiporters
Cation Exchange Proteins
Cation Exchangers (Proteins)

Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.


Didelphis
Opossum, North American
Didelphis virginiana

A genus of large OPOSSUMS in the family Didelphidae, found in the Americas. The species Didelphis virginiana is prominent in North America.


A narcotic analgesic with a long onset and duration of action.


Gambling
Gambling, Pathologic
Pathological Gambling
Gambling, Pathological

An activity distinguished primarily by an element of risk in trying to obtain a desired goal, e.g., playing a game of chance for money.


Chastetree
Chasteberry
Vitex
Chasteberry Tree
Vitex rotundifolia
Chaste Tree
Vitex agnus-castus

A genus of trees in the Lamiaceae family containing assorted flavonoids with possible analgesic and antineoplastic properties. The fruit of these trees is used in herbal preparations.


A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA.


Receptor 5, Metabotropic Glutamate
Receptor, Metabotropic Glutamate 5
Metabotropic Glutamate Receptor 5a
mGluR5b Protein
Metabotropic Glutamate Receptor 5b
mGluR5 Protein
Metabotropic Glutamate Receptor 5
mGluR5a Protein

A type I G protein-coupled receptor mostly expressed post-synaptic pyramidal cells of the cortex and CENTRAL NERVOUS SYSTEM.


Corbionax
Rytmarone
Cordarex
Amiodarone Hydrochloride
Tachydaron
SKF 33134-A
Amiodarex
Braxan
Amiodarona
Amiodarone
Trangorex
L-3428
Ortacrone
Cordarone
Kordaron
Amiohexal
Aratac
Amiobeta

An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.


9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098

An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.


Sulfonium, ((3S)-3-Amino-3-Carboxypropyl)Dimethyl-, Inner Salt

A vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.


Winterberry
Alder, Black
Holly
Ilex
Ilex verticillata

A plant genus of the family AQUIFOLIACEAE. The common name of 'holly' usually refers to this genus but may sometimes refer to similar looking plants of the MAHONIA or QUERCUS genus.


Dipotassium Oxalate
Chromium (3+) Oxalate (3:2)
Dilithium Oxalate
Aluminum Oxalate
Iron (3+) Oxalate
Chromium Oxalate
Ferric Oxalate
Potassium Oxalate (2:1)
Monopotassium Oxalate
Magnesium Oxalate (1:1)
Chromium (2+) Oxalate
Iron Oxalate
Iron (2+) Oxalate (1:1)
Sodium Oxalate
Potassium Oxalate
Monoammonium Oxalate
Disodium Oxalate
Ammonium Oxalate
Manganese (2+) Oxalate (1:1)
Oxalic Acid
Diammonium Oxalate
Monosodium Oxalate
Potassium Chromium Oxalate
Monohydrogen Monopotassium Oxalate
Magnesium Oxalate

A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.


Breast Cancer, Male
Male Breast Cancer
Breast Tumors, Male
Neoplasms, Breast, Male
Neoplasms, Male Breast
Tumors, Breast, Male
Breast Neoplasms, Male
Male Breast Neoplasms
Breast Carcinoma, Male

Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.


Type I Arnold-Chiari Malformation
Type IV Arnold-Chiari Malformation
Arnold-Chiari Malformation, Type III
Arnold-Chiari Malformation, Type IV
Arnold-Chiari Malformation, Type II
Arnold-Chiari Malformation, Type I
Arnold-Chiari Malformation, Type 4
Arnold-Chiari Malformation, Type 3
Arnold-Chiari Deformity
Arnold-Chiari Syndrome
Type III Arnold-Chiari Malformation
Arnold-Chiari Malformation, Type 2
Malformation, Arnold-Chiari
Arnold-Chiari Malformation, Type 1
Chiari Malformation Type I
Chiari Malformation Type 2
Chiari Malformation Type II
Arnold-Chiari Malformation
Type II Arnold-Chiari Malformation

A group of congenital malformations involving the brainstem, cerebellum, upper spinal cord, and surrounding bony structures. Type II is the most common, and features compression of the medulla and cerebellar tonsils into the upper cervical spinal canal and an associated MENINGOMYELOCELE. Type I features similar, but less severe malformations and is without an associated meningomyelocele. Type III has the features of type II with an additional herniation of the entire cerebellum through the bony defect involving the foramen magnum, forming an ENCEPHALOCELE. Type IV is a form a cerebellar hypoplasia. Clinical manifestations of types I-III include TORTICOLLIS; opisthotonus; HEADACHE; VERTIGO; VOCAL CORD PARALYSIS; APNEA; NYSTAGMUS, CONGENITAL; swallowing difficulties; and ATAXIA. (From Menkes, Textbook of Child Neurology, 5th ed, p261; Davis, Textbook of Neuropathology, 2nd ed, pp236-46)


Cytotoxic T-Lymphocyte Associated 1 Protein

A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.


Cysteamine Bitartrate
Cysteamine
beta-Mercaptoethylamine
Cysteamine, 35S-Labeled
Cysteamine Maleate (1:1)
Cysteamine Hydrobromide
Mercaptamine
Mercamine
2-Aminoethanethiol
Cysteamine Tosylate
Becaptan
Cysteinamine
Cystagon
Mercaptoethylamine
Cysteamine Hydrochloride
Cysteamine Dihydrochloride
Cysteamine Tartrate
Cysteamine Tartrate (1:1)

A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.


Vitelliform Macular Dystrophy, Early-Onset

Vitelliform Macular Dystrophy, Juvenile-Onset

Macular Degeneration, Polymorphic Vitelline

Adult-Onset Vitelliform Macular Dystrophy

Foveomacular Dystrophy, Adult-Onset, With Choroidal Neovascularization

Macular Dystrophy, Vitelliform, Adult-Onset

Vitelliform Macular Dystrophy, Adult-Onset

Juvenile-Onset Vitelliform Macular Dystrophy

Autosomal dominant hereditary maculopathy with childhood-onset accumulation of LIPOFUSION in RETINAL PIGMENT EPITHELIUM. Affected individuals develop progressive central acuity loss, and distorted vision (METAMORPHOPSIA). It is associated with mutations in bestrophin, a chloride channel.


Monoparesis
Crural Paresis
Muscle Paresis
Paresis
Hemiparesis
Muscular Paresis
Lower Extremity Paresis
Brachial Paresis
Upper Extremity Paresis

A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). In the older literature, paresis often referred specifically to paretic neurosyphilis (see NEUROSYPHILIS). "General paresis" and "general paralysis" may still carry that connotation. Bilateral lower extremity paresis is referred to as PARAPARESIS.


Phosphatidylinositol 3-Kinase p100 Subunit

Class III Phosphatidylinositol 3-Kinase Catalytic Subunit

Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3

Phosphatidylinositol 3-Kinase, Class III

Class III Phosphatidylinositol 3-Kinases

A phosphatidylinositol 3-kinase subclass that includes enzymes whose specificity is limited to 1-phosphatidylinositol. Members of this class play a role in vesicular transport and in the regulation of TOR KINASES.


Bladder
Bladder Detrusor Muscle
Urinary Bladder
Detrusor Urinae

A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.


A plant genus of the family FABACEAE that is a source of prosopis gum.


Flax, New Zealand
Asphodelaceae
Bulbine
Xanthorrhoeaceae
Phormium

A plant genus of the family Xanthorrhoeaceae.


Facility Regulation
Facility Regulation and Control
Regulation, Facility
Facility Control

Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.


Opiates, Endogenous
Opiate Peptides
Opioid Peptide
Opioid Peptides
Endogenous Opiates

The endogenous peptides with opiate-like activity. The three major classes currently recognized are the ENKEPHALINS, the DYNORPHINS, and the ENDORPHINS. Each of these families derives from different precursors, proenkephalin, prodynorphin, and PRO-OPIOMELANOCORTIN, respectively. There are also at least three classes of OPIOID RECEPTORS, but the peptide families do not map to the receptors in a simple way.


A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.


Flags
Caduceus
Insignia
Insigne
Emblems and Insignia
Emblems
Flags and Banners

Figures or symbols identifying or representing organizations or societies.


Antibiotic Resistance, Microbial
Antimicrobial Drug Resistance
Antibiotic Resistance
Drug Resistance, Microbial

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).


4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid, Disodium Salt

A non-penetrating amino reagent (commonly called SITS) which acts as an inhibitor of anion transport in erythrocytes and other cells.


Inappropriate Thyroid Stimulating Hormone Secretion

Thyroid Stimulating Hormone, Inappropriate Secretion

Follicle Stimulating Hormone, Inappropriate Secretion

Inappropriate Follicle Stimulating Hormone Secretion

Inappropriate Luteinizing Hormone Secretion

Luteinizing Hormone, Inappropriate Secretion

Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.


A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.


A plant genus of the family SAXIFRAGACEAE.


Ellagitannins
Pyrogallol Tannins
Ellagi-Tannins
Gallotannins
Hydrolyzable Tannins
Gallo-Tannins

Polymeric derivatives of GALLIC ACID that are esters of a sugar.


Antimicrobial Agents
Microbicides
Anti-Infective Agents
Antiinfective Agents
Anti-Microbial Agents

Generically, any agent that destroys microbes. However, usage of the term is increasingly being confined to agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES.


Hospital Moving
Health Facility Moving
Moving, Health Facility
Moving, Hospital

The relocation of health care institutions or units thereof. The concept includes equipment relocation.


Cholecystokinin Octapeptide Receptors
Cholecystokinin Receptor
Pancreozymin Receptors
Cholecystokinin Receptors
CCK-4 Receptors
Receptors, Sincalide
CCK-8 Receptors
Receptors, Cholecystokinin
Receptors, Cholecystokinin Octapeptide
CCK Receptor
Receptors, CCK-4
Receptors, Pancreozymin
Receptors, Caerulein
CCK Receptors
Receptors, CCK-8
Sincalide Receptors
Receptors, CCK
Caerulein Receptors

Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.


Acanthoma, Pilar Sheath
Acanthoma, Clear Cell
Acanthoma
Acanthoma, Degos

Benign follicular tumor usually of the upper lip.


Fluoroplast
Polytef
Expanded PTFE
Polytetrafluoroethylene
GORE-TEX
TFE
Tarflen
Goretex
Politef
PTFE
FEP
Fluon
Teflon

Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.


Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit

Retinal Phosphodiesterase, delta Subunit

Rod cGMP Phosphodiesterase, beta Subunit

Retinal Phosphodiesterase, alpha Subunit

Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit

Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit

Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.


A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.


Transportins Karyopherins Exportins Transportin Importin Importins

A subclass of karyopherins that function specifically to import molecules into the nucleus.


Deferoximine
Deferoxamine Mesylate
Desferroxamine
Deferoxamine Methanesulfonate
Deferrioxamine B
Deferoxamine Mesilate
Deferoxamine B
Desferal
Desferrioxamine
Desferrioxamine B
Desferrioxamine B Mesylate
Deferoxamine
Desferioximine

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.


BRL-2288
Tarcil
Ticar
Ticarcillin
Ticillin
Ticarpen
Ticarcillin Disodium

An antibiotic derived from penicillin similar to CARBENICILLIN in action.


Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein

Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein

Osmotic Response Element Binding Protein

Nuclear Factor of Activated T-Cells 5 Protein

Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein

Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein

A signal-dependent transcription factor that controls cellular response to osmotic stress. NFAT5 is closely related to NFATC PROTEINS but resides constitutively in the CELL NUCLEUS and operates independently of CALCINEURIN and TRANSCRIPTION FACTOR AP-1.


Intermediate-Conductance Calcium-Activated Potassium Channels

Potassium Channels, Intermediate-Conductance Calcium-Activated

Fibroblast Intermediate Conductance Potassium Channel

A major class of calcium-activated potassium channels that were originally discovered in ERYTHROCYTES. They are found primarily in non-excitable CELLS and set up electrical gradients for PASSIVE ION TRANSPORT.


Alpers Progressive Infantile Poliodystrophy

Neuronal Degeneration Of Childhood With Liver Disease, Progressive

Progressive Neuronal Degeneration of Childhood with Liver Disease

Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis

A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4-5):267-73)


PTH(1-34)
Parathyroid Hormone Peptide (1-34)
Parathyroid Hormone (1-84)
Parathyroid Hormone (1-34)
Parathyrin
Parathyroid Hormone
PTH (1-84)
Parathormone

The 34-amino acid N-terminal sequence of parathyroid hormone that contains determinant of biological activity and species-specificity.


Single-Stranded DNA Binding Proteins
Single-Stranded DNA-Binding Protein
DNA Helix Destabilizing Proteins
DNA Single-Stranded Binding Protein
SS DNA BP
DNA-Binding Proteins
DNA Binding Protein

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.


Body Packers
Drug Mules
Body Stuffing
Body Packing
Body Stuffers
Body Pushing
Body Pushers

Persons who conceal drugs or other contraband within their body cavities.


Osteogenesis Imperfecta with Blue Sclerae

COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.


Nelumbo nucifera
American Lotus
Indian Lotus
Sacred Lotus
Nelumbo
Nelumbo lutea

A plant genus of the family NELUMBONACEAE. The common name lotus is also used for other plants such as the WATER-LILY, which they resemble, and the unrelated genus Lotus (LOTUS). Nelumbo produce the edible lotus nuts.


Replication, Autonomous
DNA Replication
Autonomous Replication

The process by which a DNA molecule is duplicated.


Gerokit
Pröcaine chlorhydrate Lavoisier
Lophakomp-Procain N
Novocaine
Procain Steigerwald
procain-loges
Procaine
Procaina Serra
Procain curasan
Hewedolor-Procain
Procain Braun
Novocain
Procain Jenapharm
Procain Rödler
Anuject
Procaine Hydrochloride
Geriocaine
Röwo Procain

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).


Interferon alpha-A
Roferon-A
Interferon-alpha 2
IFN-alpha 2
Sch-30500
Interferon alfa-2b
IFNalpha-2b, Recombinant
Interferon alpha-2
Reaferon
Ro 22-8181
Viferon
Interferon alfa-2a
IFN-alpha-2
Recombinant Interferon alpha-2a
Recombinant Interferon alpha-2b
LeIF A
Interferon alpha-2b, Recombinant
Intron A (Interferon)

A recombinant form of interferon alpha-2. This variant has LYSINE at position 23 and HISTIDINE at position 34.


Dynamic Splinting
Static Splints
Dynamic Splints
Dynamic Splint
Dynamic Orthoses
Splints
Static Splint
Static Splinting
Static Orthoses

Flexible appliances that allow for mobility and increase range of motion of injured JOINTS.


Suprax
Cefixime
FK-027
Cefixime Trihydrate
FR-17027
FK 027
Cefixime Anhydrous

A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.


Caudal Linear Nucleus of the Raphe
Interfascicular Nucleus
Superior Central Nucleus
Rostral Linear Nucleus of the Raphe
Raphe Nuclei
Rostral Linear Nucleus of Raphe
Nucleus Incertus

Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.


Finless Porpoise
Neophocaena phocaenoides
Dall Porpoise
Australophocaena dioptrica
Phocoenidae
Phocoenoides dalli
Porpoises
Spectacled Porpoise

Mammals of the family Phocoenidae comprising four genera found in the North Pacific Ocean and both sides of the North Atlantic Ocean and in various other seas. They differ from DOLPHINS in that porpoises have a blunt snout and a rather stocky body while dolphins have a beak-like snout and a slender, streamlined body. They usually travel in small groups. (From Walker's Mammals of the World, 5th ed, pp1003-4)


A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.


Schistosomiasis, Urinary
Schistosomiasis haematobia
Urogenital Schistosomiasis
Urinary Schistosomiasis
Schistosoma haematobia Infection
Schistosomiasis haematobium

A human disease caused by the infection of parasitic worms SCHISTOSOMA HAEMATOBIUM. It is endemic in AFRICA and parts of the MIDDLE EAST. Tissue damages most often occur in the URINARY TRACT, specifically the URINARY BLADDER.


Ampullary Crest
Crista Ampullaris
Semicircular Ducts

The three membranous semicircular ducts within the bony semicircular canals. They open into the UTRICLE through five openings. Each duct has at one end a sensory area called the ampullary crest. AMPULLARY HAIR CELLS of the crests sense the movement of ENDOLYMPH resulting from rotation of the head.


A family of ribonucleoproteins that were originally found as proteins bound to nascent RNA transcripts in the form of ribonucleoprotein particles. Although considered ribonucleoproteins they are primarily classified by their protein component. They are involved in a variety of processes such as packaging of RNA and RNA TRANSPORT within the nucleus. A subset of heterogeneous-nuclear ribonucleoproteins are involved in additional functions such as nucleocytoplasmic transport (ACTIVE TRANSPORT, CELL NUCLEUS) of RNA and mRNA stability in the CYTOPLASM.


Sympathomimetic Drugs
Sympathomimetic Effect
Sympathomimetic Effects
Amines, Sympathomimetic
Sympathomimetics
Sympathomimetic Agents

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.


Surgical Procedure, Gastrointestinal
Gastrointestinal Surgical Procedure
Digestive System Surgical Procedures
Gastrointestinal Surgical Procedures
Procedures, Gastrointestinal Surgical
Surgical Procedures, Digestive System
Procedure, Digestive System Surgical
Surgical Procedures, Gastrointestinal
Digestive System Surgical Procedure
Procedure, Gastrointestinal Surgical
Procedures, Digestive System Surgical
Surgical Procedure, Digestive System

Surgery performed on the digestive system or its parts.


Microtubule-Associated Proteins
MAP1 Microtubule-Associated Protein
MAP3 Microtubule-Associated Protein
MAP2 Microtubule-Associated Protein
Microtubule-Associated Protein 1
Microtubule-Associated Protein 2
Microtubule-Associated Protein 3
Microtubule Associated Proteins

High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.


Cardiomyopathies, Secondary
Primary Myocardial Diseases
Myocardiopathies
Cardiomyopathies, Primary
Myocardial Diseases
Secondary Myocardial Diseases
Myocardial Diseases, Secondary
Cardiomyopathies
Myocardial Diseases, Primary

A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).


AGR16 Protein
Sphingosine-1-Phosphate Receptor1
G-Protein Coupled Receptor H218
Sphingosine-1-Phosphate Receptor 2
Sphingosine-1-Phosphate Receptor 4
Edg-5 Receptor
Receptor, Sphingosine-1-Phosphate
Sphingosine 1-Phosphate Receptor
Sphingosine-1-Phosphate Receptor
Sphingosine-1-Phosphate Receptors
Edg Receptors
S1P5 Receptor
S1P1 Receptor
Nrg-1 Receptor
Sphingosine-1-Phosphate Receptor 3
S1P2 Receptor
H218 Protein
Sphingosine-1-Phosphate Receptor 5
S1P Receptor
S1P3 Receptor
EDG5 Protein
S1P4 Receptor

A subfamily of lysophospholipid receptors with specificity for sphingosine-1-phosphate (e.g., FINGOLIMOD), sphinganine 1-phosphate, 4-hydroxysphinganine 1-phosphate.


Silvadene
Sicazine
Dermazin
Sulfafdiazine, Silver
Flamazine
Brandiazin
SSD
Thermazene
SSD AF
Sulfargen
Silvederma
Flammazine
Silver Sulfadiazine

Antibacterial used topically in burn therapy.


Oxycobalt Hemoglobin
Oxyhemoglobins
Oxycobalthemoglobin
Oxyhemoglobin

A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.


Retinoblastoma Nuclear Phosphoprotein p105-Rb

Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.


Crossmatching, Blood
Blood Grouping
Blood Typing
Blood Grouping and Crossmatching

Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.


Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

Dextrocardia, Bronchiectasis, and Sinusitis

An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts.


Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.


A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.


Armoracia rusticana
Armoracia
Horseradish
Armoracia lapathifolia

A plant genus of the family BRASSICACEAE known for the root used in hot SPICES. It is also the source of HORSERADISH PEROXIDASE which is widely used in laboratories.


Imidocarb Dihydrochloride
Imidocarb
Imidocarb Hydrochloride

One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported.


Enzymes that catalyze the release of mononucleotides by the hydrolysis of the terminal bond of deoxyribonucleotide or ribonucleotide chains.


Urethral Stricture
Urethral Stenosis
Posterior Urethral Stricture
Urethral Stricture, Posterior
Anterior Urethral Stricture
Urethral Stricture, Anterior

Narrowing of any part of the URETHRA. It is characterized by decreased urinary stream and often other obstructive voiding symptoms.


Psychodidae
Lutzomyia
Sergentomyia
Sand Flies
Psychodinae
Moth Flies
Sandflies
Phlebotominae

Small, hairy, moth-like flies which are of considerable public health importance as vectors of certain pathogenic organisms. Important disease-related genera are PHLEBOTOMUS, Lutzomyia, and Sergentomyia.


A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)


Therapy, Psychoanalytic
Psychoanalytical Therapy
Balint Psychoanalytic Therapy
Therapy, Balint Psychoanalytic
Psychoanalytic Therapy
Psychoanalytic Therapy, Balint

A form of psychiatric treatment, based on Freudian principles, which seeks to eliminate or diminish the undesirable effects of unconscious conflicts by making the patient aware of their existence, origin, and inappropriate expression in current emotions and behavior.


Duane Anomaly with Radial Ray Abnormalities and Deafness

Duane Anomaly with Radial Abnormalities and Deafness

A syndrome consisting of Duane's syndrome, radial ray anomaly, and frequently, HEARING LOSS, SENSORINEURAL.


Scedosporium apiospermum
Scedosporium prolificans
Monosporium
Scedosporium
Monosporium apiospermum


Radiculitis
Nerve Root Disorder
Nerve Root Avulsion
Nerve Root Inflammation
Nerve Root Compression
Radiculopathy, Cervical
Radiculopathy

Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.


Plastic Surgery
Surgery, Esthetic
Cosmetic Surgery
Surgery, Plastic
Surgery, Cosmetic
Esthetic Surgery

The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.


Retinol-Binding Protein II, Cellular
Retinol Binding Protein 2
Cellular Retinol Binding Protein
Retinol-Binding Protein 2, Cellular
Retinol-Binding Protein 1, Cellular
Retinol-Binding Proteins, Cellular
Cellular Retinol-Binding Protein I
Retinol-Binding Protein (Type 2)
Retinol-Binding Protein 1

A subclass of retinol-binding proteins that take part in the intracellular storage and transport of RETINOL. They are both functionally and structurally distinct from PLASMA RETINOL-BINDING PROTEINS.


Heart Septal Defects, Atrial
Atrial Septal Defects
Persistent Ostium Primum
Ostium Secundum Atrial Septal Defect
Atrial Septal Defect
Atrial Septal Defect Ostium Primum

Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.


Edetic Acid, Disodium, Monopotassium Salt

A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.


CPR
Life Support, Basic Cardiac
Cardio-Pulmonary Resuscitation
Cardiopulmonary Resuscitation
Code Blue
Basic Cardiac Life Support
Mouth-to-Mouth Resuscitation

The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.


Pridazole
Tolazoline Hydrochloride
Priscol
Tolazoline
Tolazoline Monohydrochloride
Divascol
Priscoline
Benzalolin

A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.


Tramadura
Tramadol-Dolgit
Tramadol PB
Tralgiol
Tramadol Lindo
Tramadol Edigen
Theradol
Tramadol Bayvit
Ultram
Tramadol Asta Medica
Zydol
Tramadol Mabo
Zytram
Tradol-Puren
Tramadol 1A
Tramadol Bexal
Biokanol
Trama KD
Xymel 50
Trama-Dorsch
Tramadin
Ranitidin 1A Pharma
Tramadol
Zamudol
Tramadol Hydrochloride
Tramadol Ratiopharm
Tramadoc
Tramadol AL
Tramadol Lichtenstein
Topalgic
Tramadol Normon
Tiral
Tramex
Zumalgic
Takadol
Trama AbZ
Contramal
Trama 1A Pharma
K-315
Tramadol-Hameln
Tradonal
Tramadol Heumann
Tramadol-ratiopharm
Adolonta
Nobligan
Tramundin
Tramabeta
Tramadol Kern
Biodalgic
Tramadolor
Tramal
MTW-Tramadol
Tradol
Tramadol Cinfa
Tramagit
Tramadol Stada
Prontofort
Tramagetic
Tramake
Trasedal
Tramadol Basics
Jutadol
Tramadol acis
Amadol

A narcotic analgesic proposed for severe pain. It may be habituating.


A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.


American Elderberry
Elderberry
Sambucus canadensis
Elder Plant
Sambucus
Elderberries

A plant genus in the family CAPRIFOLIACEAE known for elderberries.


Adventitial Tissue
Adventitia
Tunica Adventitia
Tunica Externa
Adventitious Tissue

The outermost covering of organs, blood vessels, and other such structures in the body.


Porphyria, Acute Intermittent
Acute Porphyria
Porphobilinogen Deaminase Deficiency
PBGD Deficiency
Uroporphyrinogen Synthase Deficiency
UPS Deficiency
Hydroxymethylbilane Synthase Deficiency
Porphyria, Swedish Type

An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.


Assets, Financial
Balance Sheet
Income Statement
Financial Statements
Cash Flow Statement
Expense Statement
Liabilities, Financial
Equity, Financial
Net Worth

Formal and structured record of financial activities of a business, person, or other entity.


Pre-Excitation Syndromes
Preexcitation Syndrome

A group of conditions in which HEART VENTRICLE activation by the atrial impulse is faster than the normal impulse conduction from the SINOATRIAL NODE. In these pre-excitation syndromes, atrial impulses often bypass the ATRIOVENTRICULAR NODE delay and travel via ACCESSORY CONDUCTING PATHWAYS connecting the atrium directly to the BUNDLE OF HIS.


Lymphoproliferative Viruses
Gammaherpesvirinae
Macavirus

A subfamily of HERPESVIRIDAE characterized by variable reproductive cycles. The genera include: LYMPHOCRYPTOVIRUS and RHADINOVIRUS.


Dental Hygienists
Hygienist, Dental
Dental Hygienist
Hygienists, Dental

Persons trained in an accredited school or dental college and licensed by the state in which they reside to provide dental prophylaxis under the direction of a licensed dentist.


Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.


Transjugular Intrahepatic Portasystemic Shunt

Portasystemic Shunt, Transjugular Intrahepatic

Shunt, Transjugular Intrahepatic Portosystemic

Portosystemic Shunt, Transjugular Intrahepatic

Shunt, Transjugular Intrahepatic Portasystemic

A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of esophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (JAMA 1995;273(23):1824-30)


Tuberculosis, Urogenital
Urogenital Tuberculosis

A general term for MYCOBACTERIUM infections of any part of the UROGENITAL SYSTEM in either the male or the female.


Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits cholesterol uptake in the coronary arteries and aorta by blocking 3-hydroxy-3-methylglutaryl-CoA reductase activity.


Pathology, Oral
Oral and Maxillofacial Pathology
Pathology, Maxillofacial
Maxillofacial Pathology
Oral Pathology

A dental specialty concerned with pathology of the oral cavity.


Deficiency Disease, Ornithine Carbamoyltransferase

Ornithine Transcarbamylase Deficiency Disease

Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To

Deficiency Disease, Ornithine Transcarbamylase

Ornithine Carbamoyltransferase Deficiency Disease

An inherited urea cycle disorder associated with deficiency of the enzyme ORNITHINE CARBAMOYLTRANSFERASE, transmitted as an X-linked trait and featuring elevations of amino acids and ammonia in the serum. Clinical features, which are more prominent in males, include seizures, behavioral alterations, episodic vomiting, lethargy, and coma. (Menkes, Textbook of Child Neurology, 5th ed, pp49-50)


Optic Lobe, Non-Mammalian
Corpora Bigemina
Optic Lobe, Nonmammalian

In invertebrate zoology, a lateral lobe of the FOREBRAIN in certain ARTHROPODS. In vertebrate zoology, either of the corpora bigemina of non-mammalian VERTEBRATES. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1329)


State Health Planning, Development Agencies

State Health Planning and Development Agencies

Agencies established under PL93-641 to coordinate, conduct, and implement state health planning activities. Two primary responsibilities are the preparation of an annual State Health Plan and giving assistance to the Statewide Health Coordinating Council.


Premature separation of the normally implanted PLACENTA from the UTERUS. Signs of varying degree of severity include UTERINE BLEEDING, uterine MUSCLE HYPERTONIA, and FETAL DISTRESS or FETAL DEATH.


Baikal Skullcap
Scutellaria baicalensis
Scutellariae radix
Skullcap, Baikal
Huangqin
Huang Qin

A plant species of the genus Scutellaria, family LAMIACEAE, that contains skullcap flavone and is used in CHINESE HERBAL DRUGS.


Genetic Evolution
Evolution, Molecular
Molecular Evolution

The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.


Dental Focal Infection
Infection, Dental Focal
Focal Infection, Dental
Infections, Dental Focal
Dental Focal Infections
Focal Infections, Dental

Secondary or systemic infections due to dissemination throughout the body of microorganisms whose primary focus of infection lies in the periodontal tissues.


Fibromuscular Dysplasia
Fibromuscular Dysplasia of Arteries

An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.


p33ING Protein
Inhibitor of Growth Protein 1
ING-1 Protein
ING1 Protein

A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Reduced expression and chromosomal rearrangements of the ING1 gene are associated with different cancers including HEAD AND NECK NEOPLASMS.


A view of the world and the individual's environment as comprehensible, manageable, and meaningful, claiming that the way people view their life has a positive influence on their health.


An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.


C7 Complement
Complement C7
Complement 7
Complement Component 7

A 93-kDa serum glycoprotein encoded by C7 gene. It is a polypeptide chain with 28 disulfide bridges. In the formation of MEMBRANE ATTACK COMPLEX; C7 is the next component to bind the C5b-6 complex forming a trimolecular complex C5b-7 which is lipophilic, resembles an integral membrane protein, and serves as an anchor for the late complement components, C8 and C9.


Bioluminescent Proteins
Photoproteins
Luminescent Proteins

Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.


Bites and Stings
Stings
Stings and Bites
Bites

Injuries inflicted by the TEETH or poisoning caused by VENOMS of animals.


Prolactin Release-Inhibitory Factor
Prolactin Release-Inhibiting Factors
Prolactin Release Inhibiting Hormone
Prolactin Release-Inhibiting Hormone

A number of peptides with inhibitory activities on PROLACTIN release have been isolated from the HYPOTHALAMUS, the peripheral nervous system, and the gut. These include SOMATOSTATIN, and peptides derived from POMC and precursor for VASOPRESSIN-ASSOCIATED NEUROPHYSIN. Biogenic amine DOPAMINE is also a potent PIF.


Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)


The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.


An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.


Stem Cell Transplantation, Hematopoietic

Transplantation, Hematopoietic Stem Cell

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.


Netrin-1 Receptors
Netrin Receptors
Netrin Receptor
Receptor, Netrin

Cell surface receptors that bind NETRINS. They typically contain both IMMUNOGLOBULIN DOMAINS and FIBRONECTIN TYPE III DOMAINS and function to mediate CELL MIGRATION and AXON GUIDANCE.


Islands of Pancreas Transplantation
Transplantation, Islets of Langerhans
Islands of Langerhans Transplantation
Grafting, Islets of Langerhans
Transplantation, Islands of Pancreas
Pancreatic Islets Transplantation
Islet Transplantation
Islets of Langerhans Transplantation
Transplantation, Islet
Transplantation, Islands of Langerhans
Transplantation, Pancreatic Islets

The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.


Nuclear Localization Signal-Binding Protein

Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.


Thr-tRNA Ligase
Threonine-tRNA Ligase
Threonyl T RNA Synthetase
Threonyl-tRNA Synthetase

An enzyme that activates threonine with its specific transfer RNA. EC 6.1.1.3.


Response Latency
Reaction Time
Response Time

The time from the onset of a stimulus until a response is observed.


Degenerins
Degenerin Ion Channels
Degenerin Sodium Channels
Degenerin Sodium Ion Channels

A family of mechanosensitive sodium channels found primarily in NEMATODES where they play a role in CELLULAR MECHANOTRANSDUCTION. Degenerin sodium channels are structurally-related to EPITHELIAL SODIUM CHANNELS and are named after the fact that loss of their activity results in cellular degeneration.


Implanted Fiducials
Anatomic Fiducials
Fiducial Targets
Fiducial Markers

Materials used as reference points on or implanted in the body for diagnostic imaging or movement imaging studies.


A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC 1.1.1.171.


Histocompatibility
Immunocompatibility
Tissue Compatibility

The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.


The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)


Dihydrodiol Dehydrogenase-Bile Acid Binding Protein

Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE  to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).


Maculopapular Cutaneous Mastocytosis
Urticaria Pigmentosa

The most common form of cutaneous mastocytosis (MASTOCYTOSIS, CUTANEOUS) that occurs primarily in children. It is characterized by the multiple small reddish-brown pigmented pruritic macules and papules.


Valcyte
Valganciclovir Hydrochloride
Ganciclovir L-valyl Ester
Valganciclovir
Valcyt

A ganciclovir prodrug and antiviral agent that is used to treat CYTOMEGALOVIRUS RETINITIS in patients with AIDS, and for the prevention of CYTOMEGALOVIRUS INFECTIONS in organ transplant recipients who have received an organ from a CMV-positive donor.


Filaria sanguinis hominis
Wuchereria bancrofti
Filaria bancrofti

A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes.


A superfamily of nematodes of the order ENOPLIDA. Characteristics include a reduced alimentary tract and the presence of a trophosome. Its organisms can be present in the human intestine through ingestion of unwashed or contaminated raw vegetables.


Monomeric Clathrin Assembly Proteins
Monomeric Clathrin Adaptor Proteins
Clathrin Assembly Proteins, Monomeric

A subclass of clathrin assembly proteins that occur as monomers.


Community Mental Health Services
Health Services, Community Mental
Services, Community Mental Health
Services, Mental Health Community
Mental Health Services, Community
Assertive Community Treatment

Team treatment model designed to provide community-based and supportive psychiatric services.


C4a Complement
Complement 4a
Complement Component 4a
Complement C4a

The smaller fragment formed when complement C4 is cleaved by COMPLEMENT C1S. It is an anaphylatoxin that causes symptoms of immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE) but its activity is weaker than that of COMPLEMENT C3A or COMPLEMENT C5A.


Apolipoprotein B, Chylomicron
Apo B, Chylomicron
ApoB-48
ApoB48
Chylomicron Apolipoprotein B
Apoprotein B-48
Apo B-48
Chylomicron Apo B
Apolipoprotein B-48
Apolipoprotein B48

A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.


Signal Transducer and Activator of Transcription 6

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-4. Stat6 has been shown to partner with NF-KAPPA B and CCAAT-ENHANCER-BINDING PROTEINS to regulate GENETIC TRANSCRIPTION of interleukin-4 responsive GENES.


Vomiting, Anticipatory
Anticipatory Vomiting

Vomiting caused by expectation of discomfort or unpleasantness.


IgG4-RD
IgG4 Related Systemic Disease
IgG4-Associated Autoimmune Disease
IgG4-Related Disease
Immunoglobulin G4-Related Disease

A spectrum of systemic autoimmune diseases in which IMMUNOGLOBULIN G4 plays a pathophysiologic role. It can affect multiple organs in highly variable presentations, characterized by inflammatory lesions composed of IgG4-positive PLASMA CELLS, further infiltrated by T helper cells (T-LYMPHOCYTES, HELPER-INDUCER) when linked to progressive FIBROSIS and eventual organ damage.


Diclofenamid Daranide Dichlofenamide Glauconide Dichlorphenamide

A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.


Ornithine Carboxy-lyase
Ornithine Decarboxylase

A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.


H+-Pi Symporter
Proton-Phosphate Symporter
Proton-Phosphate Symporters
Proton-Phosphate Cotransporters

Proteins that cotransport hydrogen ions and phosphate ions across cellular membranes.


Movar virus
Bovine Herpesvirus 4
Herpesvirus 4, Bovine

A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting cattle.


Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.


Allium ascalonicum
Allium cepa var. aggregatum
Shallots
Shallot

Mildly aromatic herb in the Allium genus used in SPICES.


Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-G.


S100 Calcium Binding Protein A7
S100A7 Protein
S100-A7 Protein
Psoriasin

An S100 calcium binding protein that contains two EF HAND MOTIFS and also binds zinc. It is secreted via a non-classical secretory pathway and expressed by KERATINOCYTES and epithelial cells of the tongue. It has antimicrobial and immunomodulatory activities and is highly expressed in the skin of patients with PSORIASIS, as well as in bladder and skin epithelial carcinomas.


Mechanical Clot Disruption
Mechanical Thrombolysis

Procedures to cause the disintegration of THROMBI by physical interventions.


Phalaris
Canarygrass
Canary Grass
Grass, Canary


Arcus Senilis
Corneal Arcus
Arcus Corneae

A corneal disease in which there is a deposition of phospholipid and cholesterol in the corneal stroma and anterior sclera.


Kidney Incisions
Nephrotomy
Nephrostomy
Pyelotomy
Pyelostomy

Surgical incision into the KIDNEY PELVIS.


Leukocyte Peptidase Inhibitor, Secretory

A proteinase inhibitor found in various BODILY SECRETIONS that coat mucosal surfaces such as SEMINAL PLASMA; CERVICAL MUCUS; and bronchial secretions. It plays a role in protecting epithelial tissues from LEUKOCYTE-derived serine proteases such as NEUTROPHIL ELASTASE.


A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.


Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.


Kainic Acid Receptors
Kainic Acid Receptor
Kainate Receptor
Kainate Receptors
Receptors, Kainic Acid
Receptors, Kainate

A class of ionotropic glutamate receptors characterized by their affinity for KAINIC ACID.


HMG-AT
HMG-AT-Hook Proteins
HMG-AT Proteins
HMGA Proteins
HMGA

Proteins containing AT-HOOK MOTIFS that are rich in arginine and glycine residues. They bind to the minor grove of AT-rich regions of DNA.


The blending of separate images seen by each eye into one composite image.


Pervasive Child Development Disorders
Pervasive Development Disorders
Child Development Disorders, Pervasive

Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.


Compact Disk Read-Only Memory
CDROM
CD-ROM

An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.


Ipomoea nil
Japanese Morning Glory
Pharbitis nil

A plant species of the genus IPOMOEA, family CONVOLVULACEAE. An abundance of spontaneous mutants makes it useful in study of PLANT DNA and GENETICS.


Aniridia
Congenital Aniridia
Absent Iris
Irideremia

A congenital abnormality in which there is only a rudimentary iris. This is due to the failure of the optic cup to grow. Aniridia also occurs in a hereditary form, usually autosomal dominant.


The continuous developmental process of a culture from simple to complex forms and from homogeneous to heterogeneous qualities. It is the change of cultures over time. Research in cultural evolution tries to understand the causal relationships that shape and change human culture in both the long and the short term.


Administration, Oral
Administration, Oral Drug
Drug Administration, Oral
Oral Administration
Oral Drug Administration

The giving of drugs, chemicals, or other substances by mouth.


Replacement Therapy, Hormone
Therapy, Hormone Replacement
Hormone Replacement Therapy

Therapeutic use of hormones to alleviate the effects of hormone deficiency.


Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2

Alkylated DNA Repair Protein AlkB Homolog 2

AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase

A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA.


Glycogen Storage Disease Type 3
Debrancher Deficiency
Forbes Disease
Glycogenosis 3
Cori's Disease
Cori Disease
Limit Dextrinosis
Amylo-1,6-Glucosidase Deficiency
Glycogen Debrancher Deficiency
Glycogen Debranching Enzyme Deficiency
Glycogen Storage Disease Type III
Deficiency, Debrancher
Glycogen Storage Disease III

An autosomal recessive metabolic disorder due to deficient expression of amylo-1,6-glucosidase (one part of the glycogen debranching enzyme system). The clinical course of the disease is similar to that of glycogen storage disease type I, but milder. Massive hepatomegaly, which is present in young children, diminishes and occasionally disappears with age. Levels of glycogen with short outer branches are elevated in muscle, liver, and erythrocytes. Six subgroups have been identified, with subgroups Type IIIa and Type IIIb being the most prevalent.


A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.


The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).


Nurses, Dental
Dental Assistant
Dental Nurses
Dental Assistants
Assistant, Dental
Assistants, Dental

Individuals who assist the dentist or the dental hygienist.


A genus of PASTEURELLACEAE that consists of several species occurring in animals and humans. Its organisms are described as gram-negative, facultatively anaerobic, coccobacillus or rod-shaped, and nonmotile.


Myofedrin Oxyfedrine Oxifedrine Ildamen Oxiphedrin Oxyphedrin

A drug used in the treatment of angina pectoris, heart failure, conduction defects, and myocardial infarction. It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.


Muscle, Smooth
Smooth Muscle
Muscle, Involuntary

Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)


Any of various ruminant mammals of the order Bovidae. They include numerous species in Africa and the American pronghorn.


Reimplantation, Tooth
Tooth Replantation
Tooth Reimplantation
Replantation, Tooth

Reinsertion of a tooth into the alveolus from which it was removed or otherwise lost.


The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.


Manuka, New Zealand
Leptospermum
New Zealand Manuka

A plant genus of the family MYRTACEAE. The common name of tea tree is also used for MELALEUCA and KUNZEA.


Social Work Department, Hospital
Hospital Social Work Department

Hospital department responsible for administering and providing social services to patients and their families.


Breakpoint, Chromosome
Chromosome Breakpoint
Chromosome Breakpoints
Chromosome Breakpoint Sequence

The specific sequence of DNA where CHROMOSOME BREAKS have occurred.


Postpartum Care
Postnatal Care
Postpartum Programs

The care provided to women and their NEWBORNS for the first few months following CHILDBIRTH.


Dentistry, Public Health
Public Health Dentistry

A dental specialty concerned with the prevention of disease and the maintenance of oral health through promoting organized dental health programs at a community, state, or federal level.


GABA Receptor Agonists
GABA Receptor Agonist
gamma-Aminobutyric Acid Agonists
GABA Agonists
GABA Agonist
gamma-Aminobutyric Acid Agonist

Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).


Society, Veterinary
Societies, Veterinary
Veterinary Hospital Societies
Veterinary Society
Veterinary Societies

Organizations having institutional membership limited to veterinarians and veterinary institutions.


A surgical procedure done largely for cosmetic reasons to correct receding chins, chin misalignment, or chin excess.


Lichen Keloidalis Nuchae
Folliculitis Keloidalis Nuchae
Keloidal Acne
Acne Keloidalis
Dermatitis Papillaris Capillitii
Nuchal Keloid Acne
Acne Keloid
Folliculitis Keloidalis

A type of acneiform disorder in which secondary pyogenic infection in and around pilosebaceous structures ends in keloidal scarring. It manifests as persistent folliculitis of the back of the neck associated with occlusion of the follicular orifices. It is most often encountered in black or Asian men.


Postoperative hemorrhage from an endovascular AORTIC ANEURYSM repaired with endoluminal placement of stent grafts (BLOOD VESSEL PROSTHESIS IMPLANTATION). It is associated with pressurization, expansion, and eventual rupture of the aneurysm.


Prostaglandin Endoperoxide Synthetase
Prostaglandin-Endoperoxide Synthases
Fatty Acid Cyclo-Oxygenase
Prostaglandin G-H Synthase
Prostaglandin H Synthase
Hydroperoxide Cyclase
Prostaglandin Synthetase
Cyclo-Oxygenase
Cyclooxygenase
PGH Synthase
Prostaglandin H2 Synthetase
PGH2 Synthetase
Cyclooxygenases
Prostaglandin Cyclo-Oxygenase
Arachidonic Acid Cyclooxygenase
Prostaglandin-Endoperoxide Synthase
Prostaglandin Synthase
Prostaglandin Cyclooxygenase

Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.


Vinyl Toluene Derivatives
Allylbenzene Derivatives
3-Ethenylmethylbenzene Derivatives
2-Propenylbenzene Derivatives
Allylbenzenes
1-Methyl-1-phenylethylene Derivatives
1-Phenyl-2-propene Derivatives

Compounds that include a single 1-phenyl-2-propene moiety in their structure.


Malaria, Falciparum
Plasmodium falciparum Malaria

Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.


Reticuloendothelial System
Mononuclear Phagocyte System

Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. It includes MACROPHAGES and their precursors; PHAGOCYTES; KUPFFER CELLS; HISTIOCYTES; DENDRITIC CELLS; LANGERHANS CELLS; and MICROGLIA. The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (From Illustrated Dictionary of Immunology, 2d ed.)


Postmenopause
Post-menopausal Period
Post-Menopause
Postmenopausal Period

The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.


Mitogen-Activated Kinase Kinase Kinase Kinase 5

A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specificity for MAP KINASE KINASE 3; MAP KINASE KINASE 4; and MAP KINASE KINASE 6.


Gene Rearrangement, gamma-Chain T Cell Antigen Receptor

T-Lymphocyte Antigen Receptor gamma-Chain Gene Rearrangement

Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor

T-Cell Antigen Receptor gamma-Chain Gene Rearrangement

T Lymphocyte gamma-Chain Gene Rearrangement

Ordered rearrangement of T-cell variable gene regions coding for the gamma-chain of antigen receptors.


Midtrimester
Pregnancy Trimester, Second
Pregnancy, Second Trimester
Trimester, Second

The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.


Neoplasms, Skull Base
Skull Base Neoplasms

Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).


Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.


Tumor Necrosis Factor Ligand Superfamily Member 13

TNF- and APOL-Related Leukocyte Expressed Ligand 2 Protein

A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.


A tumorlike condition characterized by SMOOTH MUSCLE and ENDOTHELIUM proliferation of LYMPHATIC VESSELS and LYMPH NODES in the MEDIASTINUM and retroperitoneum, also in the lung. It may be manifested by chylous PLEURAL EFFUSION and ASCITES.


A bone morphogenetic protein that may play a role in CARTILAGE formation. It is a potent regulator of the growth of CHONDROCYTES and the synthesis of cartilage matrix proteins. Evidence for its role in cartilage formation can be seen in MICE, where genetic mutations that cause loss of bone morphogenetic protein 5 function result in the formation of small malformed ears.


Schistoma Infection
Katayama Fever
Bilharziasis
Schistosomiasis

Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.


Chemotherapy, Cancer, Regional Perfusion

Regional Perfusion Antineoplastic Chemotherapy

Neoplasm drug therapy involving an extracorporeal circuit with temporary exclusion of the tumor-bearing area from the general circulation during which high concentrations of the drug are perfused to the isolated part.


Muscle Glycogen Phosphorylase Deficiency

Glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise.


Xylonest
Citanest Octapressin
Propitocaine
Prilocaine
Prilocaine Hydrochloride
Citanest

A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.


Neuropsychiatric Systemic Lupus Erythematosus

Lupus Vasculitis, Central Nervous System

Central Nervous System Systemic Lupus Erythematosis

Systemic Lupus Erythematosis, Central Nervous System

Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.


Controlled Clinical Trials, Nonrandomized

Nonrandomized Controlled Trials as Topic

Non-Randomized Controlled Trials as Topic

Controlled Clinical Trials, Non-Randomized

Works about a study where participants are assigned to a treatment, procedure, or intervention by methods that are not random. Non-randomized clinical trials are sometimes referred to as quasi-experimental clinical trials or non-equivalent control group designs.


Endogenous substances produced through the activity of intact cells of glands, tissues, or organs.


Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)


Primate Immunodeficiency Viruses
Immunodeficiency Viruses, Primate
Lentiviruses, Primate

A subgenus of LENTIVIRUS comprising viruses that produce immunodeficiencies in primates, including humans.


Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.


Social Media
Social Medium
Twitter Messaging
Web 2.0

INTERNET applications such as blogs and virtual worlds used for social communication.


Acetohydroxyacid Synthetase I
Acetolactate Synthetase
Acetolactate Synthase
Acetohydroxy Acid Synthase
Acetohydroxy Acid Synthetase
Acetoxyhydroxyacid Synthase III

A flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the biosynthesis of VALINE and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of ISOLEUCINE. This enzyme was formerly listed as EC 4.1.3.18.


Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.


DNA-Binding Protein Inhibitor ID-2
Inhibitor of Differentiation 2 Protein
Inhibitor of Differentiation Protein 2
Inhibitor of DNA Binding 2 Protein

A negative regulator of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. It plays a role in regulating IMMUNOGLOBULIN E expression.


Apo E Knockout Mice
Mice, Knockout, ApoE
ApoE Knockout Mice

Strains of mice that contain genetic disruptions (knockout) of APOLIPOPROTEINS E genes. They are used as models for ATHEROSCLEROSIS research.


Synovitis, Acne, Pustlosis, Hyperostosis, and Osteomyelitis

Syndrome consisting of SYNOVITIS; ACNE CONGLOBATA; PALMOPLANTAR PUSTULOSIS; HYPEROSTOSIS; and OSTEITIS. The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome.


Factor Seven
Factor VII
Proconvertin
Stable Factor
Coagulation Factor VII
Factor 7
Blood Coagulation Factor VII

Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.


An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.


Anatomy, Comparative
Comparative Anatomy

The comparative study of animal structure with regard to homologous organs or parts. (Stedman, 25th ed)


Mesial Movement of Teeth
Mesial Drift of Teeth
Mesial Migration of Teeth

Migration of the teeth toward the midline or forward in the DENTAL ARCH. (From Boucher's Clinical Dental Terminology, 4th ed)


Infection with CHLAMYDOPHILA PSITTACI (formerly Chlamydia psittaci), transmitted to humans by inhalation of dust-borne contaminated nasal secretions or excreta of infected BIRDS. This infection results in a febrile illness characterized by PNEUMONITIS and systemic manifestations.


Antigens, CD46
CD46 Antigens
Trophoblast-Leukocyte Common Antigen
Membrane Cofactor Protein
CD46 Antigen

A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a co-factor for their inactivation by COMPLEMENT FACTOR I. It also interacts with a wide variety of pathogens and mediates the immune response.


Laminar Air-Flow Areas
Clean Rooms
Environment, Controlled
Controlled Environment

A state in which the environs of hospitals, laboratories, domestic and animal housing, work places, spacecraft, and other surroundings are under technological control with regard to air conditioning, heating, lighting, humidity, ventilation, and other ambient features. The concept includes control of atmospheric composition. (From Jane's Aerospace Dictionary, 3d ed)


Dietary Fish Proteins
Fish Proteins, Dietary
Dietary Fish Protein


Wingless-Type MMTV Integration Site Family, Member 5A

A Wnt protein and ligand for FRIZZLED RECEPTORS that may function as an inhibitor or activator of the WNT SIGNALING PATHWAY. For example, it activates signaling in the presence of Frizzled-4 but is inhibitory when coupled with ROR2 TYROSINE KINASE. It is required for axis formation during EMBRYOGENESIS and inhibits the proliferation, migration, and invasiveness of cancer cells.


The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.


Phenazine Methosulfate
5-Methylphenazinium Methyl Sulfate
Methylphenazonium Methosulfate

Used as an electron carrier in place of the flavine enzyme of Warburg in the hexosemonophosphate system and also in the preparation of SUCCINIC DEHYDROGENASE.


Advance Directive Compliance
Directive Adherence
Advance Directive Adherence

Compliance by health personnel or proxies with the stipulations of ADVANCE DIRECTIVES (or similar directives such as RESUSCITATION ORDERS) when patients are unable to direct their own care.


Ethylketazocine
Win-35197-2
Ethylketocyclazocine Methanesulfonate
Ethylketocyclazocine

A kappa opioid receptor agonist. The compound has analgesic action and shows positive inotropic effects on the electrically stimulated left atrium. It also affects various types of behavior in mammals such as locomotion, rearing, and grooming.


A usually four-wheeled automotive vehicle designed for passenger transportation.


Dentition, Adult
Dentition, Permanent
Dentition, Secondary

The 32 teeth of adulthood that either replace or are added to the complement of deciduous teeth. (Boucher's Clinical Dental Terminology, 4th ed)


Transcription Activator-Like Effector Nucleases

Nucleases, Transcription Activator-Like Effector

Artificial nucleases that cleave DNA at a defined distance from specific DNA sequences recognized by TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS. They are composed of an endodeoxyribonuclease fused to DNA-binding domains of the transcription activator-like effectors.


Methionine
Methionine, L-Isomer
Liquimeth
L-Methionine
Pedameth

A sulfur-containing essential L-amino acid that is important in many body functions.


Ventricular Pressure
Intraventricular Pressure

The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.


Equine Strongyle Infections
Infections, Equine Strongyle
Strongyle Infections, Equine
Strongylosis, Equine

Infection of horses with parasitic nematodes of the superfamily STRONGYLOIDEA. Characteristics include the development of hemorrhagic nodules on the abdominal peritoneum.


Skin Surgery
Cutaneous Surgical Procedures
Dermatologic Surgical Procedures
Dermatologic Surgery
Cutaneous Surgery

Operative procedures performed on the SKIN.


Pulp Devitalization, Dental
Dental Pulp Devitalization
Devitalization, Dental Pulp

The destruction of the vitality of the pulp of the tooth. (From Jablonski, Dictionary of Dentistry, 1992, p243)


Obsessive-Compulsive Disorder
Neurosis, Obsessive-Compulsive
Anankastic Personality

An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.


T-Cell Precursors
Precursor Cells, T-Lymphoid

Lymphocyte progenitor cells that are restricted in their differentiation potential to the T lymphocyte lineage.


Celiomycin
Viomicin
Viomycins
Viomycin
Florimycin
Vinactane
Viocin
Tuberactinomycin B

A strongly basic peptide, antibiotic complex from several strains of Streptomyces. It is allergenic and toxic to kidneys and the labyrinth. Viomycin is used in tuberculosis as several different salts and in combination with other agents.


Fluorescent Treponemal Antibody-Absorption Test

Serologic assay that detects antibodies to Treponema pallidum, the etiologic agent of syphilis. After diluting the patient's serum to remove non-specific antibodies, the serum is mixed on a glass slide with Nichol's strain of Treponema pallidum. An antigen-antibody reaction occurs if the test is positive and the bound antibodies are detected with fluoresceinated antihuman gamma-globulin antibody.


Bypass, Left Heart
Left Heart Bypass
Heart Bypass, Left

Diversion of the flow of blood from the pulmonary veins directly to the aorta, avoiding the left atrium and the left ventricle (Dorland, 27th ed). This is a temporary procedure usually performed to assist other surgical procedures.


Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.


Lanthanoids
Lanthanides
Lanthanoid Series Elements

Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).


Defects, Congenital
Congenital Defects
Birth Defects
Congenital Abnormalities
Abnormalities, Congenital
Deformities

Malformations of organs or body parts during development in utero.


Nephrolithotomy, Percutaneous
Percutaneous Nephrolithotomy

Surgical removal of large KIDNEY CALCULI by means of a percutaneous nephroscope which is passed into the KIDNEY PELVIS through a track created in the patient's back.


Scavenger Receptors, Class F
SR-F Proteins

A group of structurally related scavenger receptors expressed predominately by ENDOTHELIAL CELLS. They-contain repeats of EPIDERMAL GROWTH FACTOR-like cysteine-rich motifs in their extracellular domains.


Bis(Chloromethyl) Ether
Bis(Chloromethyl)Ether
Dichloromethyl Ether
Chloromethyl Ether

A substance that is an irritant to the eyes and respiratory tract and may be carcinogenic.


Phosphoinositide Phosphatases
Phosphoinositide Phosphatase

Phosphatases that catalyze the hydrolysis of phosphate groups on PHOSPHATIDYLINOSITOLS.


4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.


Trichuris
Trichuris trichiura
Trichocephalus

A genus of nematode worms comprising the whipworms.


FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.


Neuromata, Mucosal, With Endocrine Tumors

Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.


Hospital Nurseries
Nursery, Hospital
Hospital Nursery
Nurseries, Hospital

Hospital facilities which provide care for newborn infants.


Fenoperidine
Phenoperidine Hydrochloride
Operidine
Lealgin
R-1406
Phenoperidine

A narcotic analgesic partly metabolized to meperidine in the liver. It is similar to morphine in action and used for neuroleptanalgesia, usually with droperidol.


The complete genetic complement contained in a set of CHROMOSOMES in a protozoan.


POU Domain, Class 5, Transcription Factor 1

An octamer transcription factor that is expressed primarily in totipotent embryonic STEM CELLS and GERM CELLS and is down-regulated during CELL DIFFERENTIATION.


Hypertonia, Infantile
Hypertonia, Neonatal
Hypertonia, Sphincter
Hypermyotonia
Hypertonia, Detrusor Muscle
Muscle Hypertonia
Hypertonia, Transient
Muscular Hypertonicity
Muscle Tone Increased

Abnormal increase in skeletal or smooth muscle tone. Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES.


Acute Interstitial Pneumonia
Hamman-Rich Disease
Hamman-Rich Syndrome
Acute Interstitial Pneumonitis

Acute idiopathic interstitial pneumonitis characterized by diffuse PULMONARY ALVEOLI damage with uniform edematous connective tissue proliferation. It is often associated with extensive fibroblastic distortion of the lung parenchyma and leads to ADULT RESPIRATORY DISTRESS SYNDROME in later stages.


Microbiological Technics
Technic, Microbiologic
Technique, Microbiologic
Technics, Microbiological
Microbiological Techniques
Microbiologic Technique
Microbiologic Technic
Microbiologic Technics
Techniques, Microbiologic


Cell Programming Techniques
Cellular Reprogramming Techniques
Cell Reprogramming Techniques
Direct Cell Reprogramming Techniques
Directed Differentiation Techniques

The creation of a pluripotent stem cell or other cell type from an adult somatic cell by the forced expression of specific genes or other methods.


A nucleic acid sequence that contains an above average number of GUANINE and CYTOSINE bases.