NG-Nitroarginine
N(G)-Nitroarginine
omega-Nitroarginine
NOARG
N(omega)-Nitroarginine
Nitroarginine
N omega-Nitro-L-Arginine
NG-Nitro-L-Arginine
NO2Arg

An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)


Tosyl Compounds
Toluenesulfonyl Compounds

Toluenesulfonyl compounds with general formula CH3C6H4S(O2)R” widely used to block amino groups in the course of syntheses of drugs and other biologically active compounds.


Derivatives of QUINOLINES with fused PYRROLES and a keto group or INDOLEQUINONES with fused PIPERIDINES.


Uveomeningoencephalitic Syndrome
Syndrome, Vogt Koyanagi Harada
Vogt-Koyanagi-Harada Syndrome
VKH Syndrome
VKH (Vogt Koyanagi Harada) Syndrome
Uveomeningoencephalitis
Vogt-Koyanagi-Harada Disease
Syndrome, VKH (Vogt Koyanagi Harada)

A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)


Cervix Diseases
Uterine Cervical Diseases

Pathological processes of the UTERINE CERVIX.


A group of compounds forming the nucleus of the estrogenic steroid family.


A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.


Influenza A Virus, H7N2 Subtype
H7N2 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 7 and neuraminidase 2. It has been involved in a number of outbreaks in the 21st century on poultry farms and has been isolated a few times in humans.


Betabaculovirus
Cydia pomonella granulovirus
Granulosis Viruses
Granulovirus


Dental Curing Lights
Curing Lights, Dental
LED Dental Curing Lights
Plasma Arc Dental Curing Lights
Halogen Dental Curing Lights

Light sources used to activate polymerization of light-cured DENTAL CEMENTS and DENTAL RESINS. Degree of cure and bond strength depends on exposure time, wavelength, and intensity of the curing light.


V-Set Domain-Containing T-Cell Activation Inhibitor 1

A B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION.


Bombyx
Silkmoth
Bombyx mori
Silkmoths
Silkworms
Silkworm

A genus of silkworm MOTHS in the family Bombycidae of the order LEPIDOPTERA. The family contains a single species, Bombyx mori from the Greek for silkworm + mulberry tree (on which it feeds). A native of Asia, it is sometimes reared in this country. It has long been raised for its SILK and after centuries of domestication it probably does not exist in nature. It is used extensively in experimental GENETICS. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p519)


ACTH Syndrome, Ectopic
Ectopic ACTH Syndrome

Symptom complex due to ACTH production by non-pituitary neoplasms.


Immunomagnetic Purging
Immunomagnetic Cell Separation
Immunomagnetic Separation
Immunomagnetic Bead Technique

A cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow (BONE MARROW PURGING) of patients who are to undergo autologous bone marrow transplantation.


Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptides

A family of conserved cytidine deaminases that catalyze the DEAMINATION of CYTIDINE to URIDINE. They are characterized by N and C-terminal zinc-dependent catalytic domains and have important functions in RNA EDITING; EPIGENTIC PROCESSES; and the INNATE IMMUNE RESPONSE against viruses.


RXR beta Receptor
Retinoid X Receptor beta


Arthrogryposis Multiplex Congenita (AMC)

Persistent flexure or contracture of a joint.


Clinical Trials, Veterinary as Topic
Clinical Trials Veterinary as Topic

Works about clinical studies in which animal participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Animal participants may receive diagnostic, therapeutic, or other types of interventions.


BK polyomavirus
Human Polyomavirus BK
Polyomavirus, BK
BK Virus
Polyomavirus hominis 1

A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.


A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.


A plant genus in the CHENOPODIACEAE family.


Interstellar Dust
Interplanetary Dust
Cosmic Dust

Finely divided solid matter with particle sizes smaller than a micrometeorite, thus with diameters much smaller than a millimeter, moving in interplanetary space. (NASA Thesaurus, 1994)


NADPH Oxidase 1
Mitogenic Oxidase 1
NOX1 Protein

An NADPH oxidase that functions as a voltage-gated proton channel expressed by PHAGOCYTES, especially in the colon. It regulates intracellular pH, generates SUPEROXIDES upon activation by PHAGOCYTOSIS, and may play a role in INNATE IMMUNITY.


Post-Heparin Lipase
Postheparin Lipase
Diacylglycerol Lipase
Lipoprotein Lipase
Lipemia-Clearing Factor
Diglyceride Lipase
Heparin-Clearing Factor
Postheparin Lipoprotein Lipase

An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.


German Cockroach
Ectobiidae
Blattellidae

A family of insects in the order Dictyoptera (COCKROACHES), including genera Blattella, Parcoblatta, and Symploce.


A species of Allium used as a spice (SPICES) and traditional remedy. It contains alliin lyase and alliin, which is converted by alliin lyase to allicin, the pungent ingredient responsible for the aroma of fresh cut garlic.


Alaska Natives
Alaska's Indigenous People
Native Alaskians
Indigenous People of Alaska

Persons having origins in any indigenous people of ALASKA and their descendants and who maintain tribal affiliation, or community or cultural attachment.


Filipin III
Filipin
Desoxylagosin
Filimarisin
Filipin I
Filipin IV
U-5956
Filipin II
NSC-3364

A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.


MAC (Chromosome)
Mammalian Artificial Chromosomes
Chromosomes, Mammalian Artificial
Artificial Chromosomes, Mammalian
MACs (Chromosomes)
Chromosomes, Artificial, Mammalian

DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, that are required for successful replication, propagation to and maintainance in progeny mammalian cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.


Persons With Hearing Impairments
Hearing Impaired Persons
Deaf Persons
Hard of Hearing Persons
Hearing Disabled Persons

Persons with any degree of loss of hearing that has an impact on their activities of daily living or that requires special assistance or intervention.


Amyloidosis, Familial
Amyloidosis, Hereditary

Diseases in which there is a familial pattern of AMYLOIDOSIS.


Choledocholithiasis
Cholelithiasis, Common Bile Duct

Presence or formation of GALLSTONES in the COMMON BILE DUCT.


Sulfur-containing compounds also known as thioketones of general formula R2C=S.


Adenosine A2A Receptors
Receptor, Adenosine A2A
Adenosine A(2A) Receptor
Adenosine A2A Receptor

A subclass of adenosine A2 receptors found in LEUKOCYTES, the SPLEEN, the THYMUS and a variety of other tissues. It is generally considered to be a receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.


Receptors, alpha-v beta-3 Integrin
Integrin alphaVbeta3
Vitronectin Receptor
alpha-v beta-3 Integrin Receptors
Integrin alpha-v beta-3

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).


Immunoelectrophoresis, Two-Dimensional
Immunoelectrophoresis, Crossed
Immunoelectrophoresis, 2-D
Immunoelectrophoresis, 2D

Immunoelectrophoresis in which a second electrophoretic transport is performed on the initially separated antigen fragments into an antibody-containing medium in a direction perpendicular to the first electrophoresis.


A branch of medicine concerned with the role of socio-environmental factors in the occurrence, prevention and treatment of disease.


An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)


Abortifacient Agents, Steroidal
Steroid Abortifacients

Steroidal compounds with abortifacient activity.


Fractures, Malunited
Fractures, Abnormal Union
Fractures, Crossunited
Malunion, Fracture
Fracture Malunion

Union of the fragments of a fractured bone in a faulty or abnormal position. If two bones parallel to one another unite by osseous tissue, the result is a crossunion. (From Manual of Orthopaedic Terminology, 4th ed)


Diaphragmatic Hernia
Hernia, Diaphragmatic

Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.


alpha-Immunoglobulin Heavy Chain
Ig alpha Chains
Immunoglobulins, alpha-Chain
alpha-Chain Immunoglobulins
Immunoglobulin alpha-Chains
Immunoglobulin alpha-Chain
alpha-Immunoglobulin Heavy Chains

The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.


An enzyme which catalyzes the hydrolysis of diphosphate (DIPHOSPHATES) into inorganic phosphate. The hydrolysis of pyrophosphate is coupled to the transport of HYDROGEN IONS across a membrane.


Arsenite-Transporting ATPase
Arsenite Transporting ATPases
Arsenite-Translocating ATPase

Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions.


Transfer RNA, Asp
RNA, Transfer, Asp
tRNA(Asp)
tRNAAsp
Aspartic Acid-Specific tRNA

A transfer RNA which is specific for carrying aspartic acid to sites on the ribosomes in preparation for protein synthesis.


Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.


Trigeminal Nuclear Complex
Trigeminal Nuclei

Nuclei of the trigeminal nerve situated in the brain stem. They include the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), the principal sensory nucleus, the mesencephalic nucleus, and the motor nucleus.


Glial Cell Tumors
Malignant Glioma
Glioma
Mixed Glioma

Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)


Balaenoptera physalus
Finback Whale
Fin Whale

The species Balaenoptera physalus, in the family Balaenopteridae, characterized by a large, strongly curved, dorsal fin. It is the second largest of the WHALES, highly migratory, but rarely seen near the shore.


Receptor, Adrenergic, beta-2
beta-2 Adrenergic Receptors
beta 2 Adrenergic Receptors
Adrenergic beta-2 Receptors
Receptors, Adrenergic, beta-2
Adrenergic Receptor, beta-2
Receptors, beta-2 Adrenergic

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.


KATP Channels
ATP-Sensitive Potassium Channels

Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC BETA CELLS; and KIDNEY COLLECTING DUCTS. KATP channel blockers include GLIBENCLAMIDE and mitiglinide whereas openers include CROMAKALIM and minoxidil sulfate.


Service, Hospital Chaplaincy
Chaplaincy Service, Hospital
Hospital Chaplaincy Service
Service, Chaplaincy Hospital

Hospital department which administers religious activities within the hospital, e.g., pastoral care, religious services.


Ergocornine, 9,10-dihydro-
Dihydroergocornine Mesylate
Dihydroergocornine Monomesylate
Dihydroergocornine

A 9,10alpha-dihydro derivative of ERGOTAMINE that contains isopropyl sidechains at the 2' and 5' positions of the molecule.


Lysine Vasopressin
Lypressin
8-Lysine Vasopressin
Vasopressin, Lysine
Diapid
Postacton
Lysyl Vasopressin
Lys-Vasopressin

The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.


Racial Bias
Racism
Racial Discrimination
Racial Prejudice
Covert Racism

Practices or policies that appear to be 'neutral' or 'fair' because they treat everyone in the same way but actually adversely affect a higher proportion of people of one racial, national or ethnic group. It can occur even when there is no intention to discriminate.


Vibrio cholerae Serogroup O1
Vibrio cholerae O1

Strains of VIBRIO CHOLERAE containing O ANTIGENS group 1. All are CHOLERA-causing strains (serotypes). There are two biovars (biotypes): cholerae and eltor (El Tor).


Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.


An inward slant of the thigh in which the knees are close together and the ankles far apart. Genu valgum can develop due to skeletal and joint dysplasias (e.g., OSTEOARTHRITIS; HURLER SYNDROME); and malnutrition (e.g., RICKETS; FLUORIDE POISONING).


Home Care Services
Care Services, Home
Home Care
Services, Home Care
Domiciliary Care

Care of a patient at home, by family members and/or health personnel. (Bioethics Thesaurus)


Procollagen Peptidase
Procollagen N-Proteinase
Procollagen N-Endopeptidase

An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.


Prospective Pricing
Discretionary Adjustment Factor
Reimbursement, Prospective
Adjustment, Discretionary
Prospective Reimbursement
Prospective Payment System

A system wherein reimbursement rates are set, for a given period of time, prior to the circumstances giving rise to actual reimbursement claims.


A plant genus of the family Xanthorrhoeaceae. Members contain steroidal saponins.


Circulation of water among various ecological systems, in various states, on, above, and below the surface of the earth.


The genetic complement of a plant (PLANTS) as represented in its DNA.


A plant genus of the family ASTERACEAE. INULIN and SESQUITERPENES have been found in it.


O-Antigens
O Antigen, Bacterial
O-Specific Polysaccharide
O Antigens
O Antigen
O-Specific Polysaccharides

The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)


Food processed and manufactured for the nutritional health of children in their first year of life.


Analysis, Blood Chemical
Blood Chemical Analysis
Chemical Analysis, Blood

An examination of chemicals in the blood.


Helix-Loop-Helix Activator USF
Upstream Stimulatory Factors
USF Transcription Factors

Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.


Periodic Leg Movements, Excessive, Sleep-Related

Sleep-Related Periodic Leg Movements, Excessive

Excessive Periodic Sleep-Related Leg Movements

Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)


POU Domain, Class 4, Transcription Factor 2

A POU domain factor that represses GENETIC TRANSCRIPTION of GENES encoding NEUROFILAMENT PROTEINS, alpha internexin, and SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.


Lateral Preoptic Area
Preoptic Nuclei
Preoptic Area
Area Preoptica
Medial Preoptic Area

Region of hypothalamus between the ANTERIOR COMMISSURE and OPTIC CHIASM.


Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.


Education, Dental, Graduate
Graduate Dental Education
Dental Education, Graduate

Educational programs for dental graduates entering a specialty. They include formal specialty training as well as academic work in the clinical and basic dental sciences, and may lead to board certification or an advanced dental degree.


Streptococcus Phages
Streptococcus Bacteriophages
Streptococcal Phages


An FAD-dependent oxidoreductase found primarily in BACTERIA. It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This enzyme was formerly listed as EC 1.1.1.68 and 1.1.99.15.


Carotid-Femoral Pulse Wave Velocities
Carotid-Femoral Pulse Wave Velocity

The transit time of an AORTIC PRESSURE wave between the COMMON CAROTID ARTERY and the COMMON FEMORAL ARTERY. It is a standard measure of ARTERIAL STIFFNESS.


MDCK Cells
Madin Darby Canine Kidney Cells

An epithelial cell line derived from a kidney of a normal adult female dog.


Carbonmonoxyhemoglobin
Carboxyhemoglobin C
Carbonylhemoglobin
Carbomonoxyhemoglobin
Carboxyhemoglobin
Carboxyhemoglobin A


Two offspring from the same PREGNANCY. They are from two OVA, fertilized at about the same time by two SPERMATOZOA. Such twins are genetically distinct and can be of different sexes.


ortho-Phthalic Aldehyde
ortho-Phthalaldehyde
o-Phthalaldehyde
Orthophthaldialdehyde
o-Phthaldialdehyde

A reagent that forms fluorescent conjugation products with primary amines. It is used for the detection of many biogenic amines, peptides, and proteins in nanogram quantities in body fluids.


Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.


AlCl3
Aluminum Trichloride
Drysol
Aluminum Chloride
Aluminum Chloride Hexahydrate
Aluminum Chloride, Anhydrous

A compound with the chemical formula AlCl3; the anhydrous salt is used as a catalyst in organic chemical synthesis, and hydrated salts are used topically as antiperspirants, and for the management of HYPERHYDROSIS.


GRB10 Protein
Maternally Expressed Gene 1 Protein
GRB10 Adaptor Protein
Growth Factor Receptor-Bound Protein 10

A binding partner for several RECEPTOR PROTEIN-TYROSINE KINASES, including INSULIN RECEPTOR and INSULIN-LIKE GROWTH FACTOR RECEPTOR. It contains a C-terminal SH2 DOMAIN and mediates various SIGNAL TRANSDUCTION pathways.


Liver-Specific Transcription Factor LF-B1

Hepatocyte nuclear factor 1-alpha is a transcription factor found in the LIVER; PANCREAS; and KIDNEY that regulates HOMEOSTASIS of GLUCOSE.


Alcoholic Pancreatitis
Pancreatitis, Alcoholic

Acute or chronic INFLAMMATION of the PANCREAS due to excessive ALCOHOL DRINKING. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.


Disease of LYMPH NODES which are abnormal in size, number or consistency.


Viral Encephalitis, Japanese B
Japanese B Encephalitis
Encephalitis, Japanese B
Japanese Encephalitis
Japanese B Viral Encephalitis
Encephalitis, Japanese

A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)


Insulin-Degrading Enzyme
Insulin Proteinase
Insulinase
Insulin Protease
Insulysin

An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.


DNA-Directed DNA Polymerase
DNA-Dependent DNA Polymerases
DNA Polymerase N3
DNA Polymerases

DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.


A plant species of the family CLUSIACEAE. The common name of 'Bitter Kola' is sometimes also used to refer to COLA.


Transplantation, Brain Tissue
Grafting, Brain Tissue
Brain Tissue Transplantation

Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.


Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.


Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.


Elastomers, Silicone
Elastosil
Rubber Silicone
Silicone Elastomers
Microfil
Silicone Rubber
SE-30

Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.


An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)


Nitrimidazine Naxogin K-1900 Esclama Nimorazole Nulogyl

An antitrichomonal agent which is effective either topically or orally and whose urinary metabolites are also trichomonicidal.


An abnormal passage in the URINARY BLADDER or between the bladder and any surrounding organ.


Canine Distemper Virus
Distemper Virus, Canine

A species of MORBILLIVIRUS causing distemper in dogs, wolves, foxes, raccoons, and ferrets. Pinnipeds have also been known to contract Canine distemper virus from contact with domestic dogs.


An order of fungi in the phylum BASIDIOMYCOTA having macroscopic basidiocarps. The members are characterized by their saprophytic activities as decomposers, particularly in the degradation of CELLULOSE and LIGNIN. A large number of species in the order have been used medicinally. (From Alexopoulos, Introductory Mycology, 4th ed, pp504-68)


Patient Protection and Affordable Care Act

An Act prohibiting a health plan from establishing lifetime limits or annual limits on the dollar value of benefits for any participant or beneficiary after January 1, 2014. It permits a restricted annual limit for plan years beginning prior to January 1, 2014. It provides that a health plan shall not be prevented from placing annual or lifetime per-beneficiary limits on covered benefits. The Act sets up a competitive health insurance market.


beta-Hydroxyacyl Dehydrogenases
3-Hydroxyacyl CoA Dehydrogenases

Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis.


Anti-Dyskinesia Agents
Movement Disorder Agents

Drugs used in the treatment of movement disorders. Most of these act centrally on dopaminergic or cholinergic systems. Among the most important clinically are those used for the treatment of Parkinson disease (ANTIPARKINSON AGENTS) and those for the tardive dyskinesias.


PAX6 Protein
Pax-6 Protein
Aniridia Type II Protein
Paired Box Transcription Factor 6
Paired Box Gene 6 Protein
Paired Box Protein Pax-6
Pax6.2 Protein
PAX6 Transcription Factor
Transcription Factor PAX6
Pax6.1 Protein
Oculorhombin

A paired box transcription factor that has important functions in the development of the eye, nose, central nervous system and pancreas. Mutations in the PAX6 gene are associated with ocular disorders such as ANIRIDIA.


N-Acylsphingosine Amidohydrolase
Ceramidases
Acylsphingosine Deacylase
Ceramidase

Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.


env Gene
env Genes
HIV rev-Responsive Element
rev-Responsive Element
Genes, env

DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses. The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV), termed the rev-responsive element (RRE).


Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.


Hair Bleaching Agents
Hair Lightening Agents

Chemicals that are used to oxidize pigments in HAIR.


Knottins
Knottin
Cystine-Knot Miniproteins

A structurally-related family of small proteins that form a stable tertiary fold pattern which is supported by a series of disulfide bonds. The arrangement of disulfide bonds between the CYSTEINE moieties results in a knotted structure which is unique to this family of proteins.


Osteosynthesis, Fracture
Fracture Fixation, Internal

The use of internal devices (metal plates, nails, rods, etc.) to hold the position of a fracture in proper alignment.


Low Sperm Count
Hypospermatogenesis
Oligozoospermia
Oligoasthenoteratozoospermia
Oligospermia

A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.


Mitogen-Activated Protein Kinase Kinase 7

A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to CYTOKINES.


Physician, Woman
Physicians, Women
Women Physicians


Facteur Thymique Serique
Thymic Serum Factor
Factor, Thymic Circulating
Thymuline
Thymulin
Serum Thymic Factor
Thymic Factor, Circulating
Circulating Factor, Thymic
Nonathymulin

A thymus-dependent nonapeptide found in normal blood. Stimulates the formation of E rosettes and is believed to be involved in T-cell differentiation.


Fibrinogens, Abnormal
Abnormal Fibrinogens

Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.


Clinical Trials Data Monitoring Committees

Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.


Therapy, Aroma
Aromatherapy
Aroma Therapy

The use of fragrances and essences from plants to affect or alter a person's mood or behavior and to facilitate physical, mental, and emotional well-being. The chemicals comprising essential oils in plants has a host of therapeutic properties and has been used historically in Africa, Asia, and India. Its greatest application is in the field of alternative medicine. (From Random House Unabridged Dictionary, 2d ed; from Dr. Atiba Vheir, Dove Center, Washington, D.C.)


Ribonucleic acid in protozoa having regulatory and catalytic roles as well as involvement in protein synthesis.


Glycoside hydrolases that break down glycosidic bonds in CHITIN. They are important for insect and worm morphogenesis and plant defense against pathogens. Human chitinases may play a role in the etiology of allergies and asthma.


Solute Carrier Family 2, Facilitated Glucose Transporter, Member 1 Protein

A ubiquitously expressed glucose transporter that is important for constitutive, basal GLUCOSE transport. It is predominately expressed in ENDOTHELIAL CELLS and ERYTHROCYTES at the BLOOD-BRAIN BARRIER and is responsible for GLUCOSE entry into the BRAIN.


Non-Profit Organizations
Organizations, Nonprofit
Organizations, Non-Profit
Nonprofit Organizations

Organizations which are not operated for a profit and may be supported by endowments or private contributions.


Video Capsule Endoscopes
Capsule Endoscopes

A pill sized videocamera encased in a capsule. It is designed to be swallowed and subsequently traverse the gastrointestinal tract while transmitting diagnostic images along the way.


Carbonic Anhydrase
Carbonate Dehydratase
Carbonic Anhydrases

A family of zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They play an important role in the transport of CARBON DIOXIDE from the tissues to the LUNG. EC 4.2.1.1.


Spasmodic contraction of the smooth muscle of the bronchi.


A 28-amino acid peptide with the same biological activities of somatostatin-14 but with a 14-amino acid extension at the N-terminal. SRIF-28 is the major form of somatostatin in the GASTROINTESTINAL TRACT.


Lymphoid Hyperplasia, Reactive
Lymphocytoma
Hyperplasia, Reactive Lymphoid
Pseudolymphoma

A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (From Dorland, 28th ed & Stedman, 26th ed)


Phospholipase A2 Inhibitors
Phospholipase A2 Antagonists

Compounds that inhibit or block the activity of a PHOSPHOLIPASE A2 enzyme.


Fetus
Fetal Structures
Fetal Tissue
Retained Fetus
Mummified Fetus
Fetuses

A fetus that is not delivered at the initial PARTURITION of a MULTIPLE PREGNANCY, usually of twins in humans. The retained fetus can progress to term and result in LIVE BIRTH.


Total Ankle Replacement
Ankle Replacement Arthroplasty
Arthroplasty, Replacement, Ankle


beta-Sulfoalanine
3-Sulfoalanine
Cysteic Acid
Cysteate

Beta-Sulfoalanine. An amino acid with a C-terminal sulfonic acid group which has been isolated from human hair oxidized with permanganate. It occurs normally in the outer part of the sheep's fleece, where the wool is exposed to light and weather.


Attentional Bias
Biased Attention
Attentional Biases

An increased focus or awareness of certain stimuli over others, which influence behavior.


The specialized postsynaptic region of a muscle cell. The motor endplate is immediately across the synaptic cleft from the presynaptic axon terminal. Among its anatomical specializations are junctional folds which harbor a high density of cholinergic receptors.


Phosphatidate Phosphohydrolase
Phosphatidic Acid Phosphohydrolase
Phosphatidic Acid Phosphatase
Phosphatidate Phosphatase

A phosphomonoesterase involved in the synthesis of triacylglycerols. It catalyzes the hydrolysis of phosphatidates with the formation of diacylglycerols and orthophosphate. EC 3.1.3.4.


Infection involving the tissues or organs in the PELVIS.


A plant genus of the family BRASSICACEAE. Member species are ornamentals grown for their numerous small white, yellow, pink, or purplish flowers.


DNA Repair And Recombination Protein RAD52

Rad52 DNA Repair and Recombination Protein

A DNA-binding protein that mediates DNA REPAIR of double strand breaks, and HOMOLOGOUS RECOMBINATION.


The presence of parasites in food and food products. For the presence of bacteria, viruses, and fungi in food, FOOD MICROBIOLOGY is available.


Infections with nematodes of the genus GNATHOSTOMA, superfamily THELAZIOIDEA. Gnathostomiasis is a food-borne zoonosis caused by eating undercooked or raw fish or meat.


Influenza B virus
Orthomyxoviruses Type B
Influenza Viruses Type B

Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.


Doppler Echocardiography, Pulsed
Pulsed Doppler Echocardiography
Echocardiography, Pulsed Doppler
Doppler Pulsed Echocardiography
Echocardiography, Doppler Pulsed
Pulsed Echocardiography, Doppler
Echocardiography, Doppler, Pulsed

Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.


Familial Hypobetalipoproteinemia
Hypo beta Lipoproteinemia
Hypobetalipoproteinemia
Hypobetalipoproteinemias

Conditions with abnormally low levels of BETA-LIPOPROTEINS (low density lipoproteins or LDL) in the blood. It is defined as LDL values equal to or less than the 5th percentile for the population. They include the autosomal dominant form involving mutation of the APOLIPOPROTEINS B gene, and the autosomal recessive form involving mutation of the microsomal triglyceride transfer protein. All are characterized by low LDL and dietary fat malabsorption.


Lynestrenol, (9 beta, 10 alpha,17 alpha)-Isomer

A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).


Acid-Base Balance
Acid-Base Equilibrium
Anion Gap

The balance between acids and bases in the BODY FLUIDS. The pH (HYDROGEN-ION CONCENTRATION) of the arterial BLOOD provides an index for the total body acid-base balance.


Therapy, Thrombolytic
Fibrinolytic Therapy
Therapy, Fibrinolytic
Therapeutic Thrombolysis
Thrombolytic Therapy
Thrombolysis, Therapeutic

Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.


Devices for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth. (UMDNS, 1999)


HLA Class I Histocompatibility Antigen, B-7 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*07 allele family.


Bovine viral diarrhea virus 2
BVDV2
Bovine Viral Diarrhea Virus Type 2
BVDV Type 2
Diarrhea Virus 2, Bovine Viral
BVDV-2

A species of PESTIVIRUS causing systemic infections including BOVINE VIRUS DIARRHEA-MUCOSAL DISEASE and BOVINE HEMORRHAGIC SYNDROME in cattle and some other cloven-hoofed animals. There are several strains and two biotypes: cytopathic (rare) and non-cytopathic. The severity of disease appears to be strain dependent. Cytopathogenic effects do not correlate with virulence as non-cytopathic BVDV-2 is associated only with Hemorrhagic Disease, Bovine.


Implants, Molteno
Molteno Shunts
Molteno Implants

Devices implanted to control intraocular pressure by allowing aqueous fluid to drain from the anterior chamber. (Hoffman, Pocket Glossary of Ophthalmologic Terminology, 1989)


The processes of anatomical and physiological changes related to sexual or reproductive functions during the life span of a human or an animal, from FERTILIZATION to DEATH. These include SEX DETERMINATION PROCESSES; SEX DIFFERENTIATION; SEXUAL MATURATION; and changes during AGING.


Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, and Postaxial Polydactyly

Cerebroacrovisceral Early Lethality Complex

A pleiotropic disorder of human development that comprises hypothalamic HAMARTOMA; central and postaxial POLYDACTYLY; bifid EPIGLOTTIS; ANAL ATRESIA; and renal and other abnormalities. This disorder is associated with FRAMESHIFT MUTATIONS in the GLI3 gene which encodes the GLI3 protein, a KRUPPEL-LIKE TRANSCRIPTION FACTORS family member.


Female Genitourinary Diseases
Female Urogenital Diseases

Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).


A triazine used as a selective pre- and post-emergence herbicide. (From Merck Index, 11th ed)


A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)


Infusions, Intra Arterial
Infusions, Intraarterial
Infusions, Regional Arterial
Infusions, Intra-Arterial

Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.


Exostoses, Multiple Cartilaginous
Multiple Osteochondromatosis
Exostoses, Multiple
Exostoses, Multiple Hereditary
Exostosis, Hereditary Multiple
Hereditary Multiple Exostoses
Osteochondromas, Multiple
Multiple Osteochondromas
Exostoses, Hereditary Multiple
Familial Exostoses
Multiple Cartilaginous Exostoses
Multiple Hereditary Exostoses
Bessel-Hagen Disease
Exostoses, Multiple, Type I
Hereditary Multiple Exostosis
Diaphyseal Aclasis
Chondrodysplasia, Hereditary Deforming
Exostoses, Familial
Exostosis, Multiple Cartilaginous
Exostosis, Familial
Exostosis, Multiple

Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.


Second World War
World War, 1939-1945
2nd World War
World War II

Global conflict involving countries of Europe, Africa, Asia, and North America that occurred between 1939 and 1945.


Francois Dyscephalic Syndrome
Hallermann Streiff Francois Syndrome
Hallermann-Streiff Syndrome
Hallermann's Syndrome

An oculomandibulofacial syndrome principally characterized by dyscephaly (usually brachycephaly), parrot nose, mandibular hypoplasia, proportionate nanism, hypotrichosis, bilateral congenital cataracts, and microphthalmia. (Dorland, 27th ed)


Glutathione Reductase
Glutathione-Disulfide Reductase

Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.


Sampling of the liquids generated from industrial processes, sanitary fixtures and appliances, food handling, etc., to collect and analyze epidemiological information (such as pathogen levels, or concentrations of pesticides, pharmaceuticals, or other substances) from metabolic excretion products, household liquid wastes, and industrial wastes.


Cytosine Deaminase
Cytosine Aminohydrolase

An enzyme which catalyzes the deamination of CYTOSINE resulting in the formation of URACIL. It can also act on 5-methylcytosine to form THYMIDINE.


Leukemia, Eosinophilic, Acute
Eosinophilic Leukemia, Acute

A rare acute myeloid leukemia characterized by abnormal EOSINOPHILS in the bone marrow.


Atomic Force Microscopy
Scanning Force Microscopy
Force Microscopy
Microscopy, Atomic Force

A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.


Diagnostic Technic, Ophthalmological
Technique, Ophthalmological Diagnostic
Techniques, Ophthalmological Diagnostic
Diagnostic Techniques, Ophthalmologic
Diagnostic Technics, Ophthalmological
Diagnostic Technique, Ophthalmological
Technic, Ophthalmological Diagnostic
Diagnostic Techniques, Ophthalmological
Ophthalmological Diagnostic Technic
Ophthalmological Diagnostic Technique
Diagnostic Technics, Ophthalmologic
Technics, Ophthalmological Diagnostic
Ophthalmological Diagnostic Technics
Ophthalmological Diagnostic Techniques

Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.


Echo Speech
Echo Reaction
Echophrasia
Echolalia

Involuntary ("parrot-like"), meaningless repetition of a recently heard word, phrase, or song. This condition may be associated with transcortical APHASIA; SCHIZOPHRENIA; or other disorders. (From Adams et al., Principles of Neurology, 6th ed, p485)


A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.


Accountable Care Organizations
Accountable Care Organization

Organizations of health care providers that agree to be accountable for the quality, cost, and overall care of Medicare beneficiaries who are enrolled in the traditional fee-for-service program who are assigned to it. Assigned means those beneficiaries for whom the professionals in the organization provide the bulk of primary care services. (www.cms.gov/OfficeofLegislation/Downloads/Accountable CareOrganization.pdf accessed 03/16/2011)


Poisoning that results from exposure to gases such as CARBON MONOXIDE; NOBLE GASES; OXYGEN; or NATURAL GAS.


Vesicular Inhibitory Amino Acid Transport Proteins

Vesicular GABA-Glycine Transporter Proteins

Vesicular Inhibitory Amino Acid Transporter Proteins

Vesicular GABA-Glycine Transport Proteins

A family of vesicular neurotransmitter transporter proteins that sequester the inhibitory neurotransmitters GLYCINE; GAMMA-AMINOBUTYRIC ACID; and possibly GAMMA-HYDROXYBUTYRATE into SECRETORY VESICLES.


Oxygenated derivatives of cholesterol or its sterol precursors. They are generated from sterol metabolism and the interaction of cholesterol with REACTIVE OXYGEN SPECIES.


Centers for Disease Control and Prevention (U.S.)

Center for Disease Control and Prevention

United States Centers for Disease Control and Prevention

Centers for Disease Control and Prevention, U.S.

An agency of the UNITED STATES PUBLIC HEALTH SERVICE that conducts and supports programs for the prevention and control of disease and provides consultation and assistance to health departments and other countries.


mos Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mos
mos Proto-Oncogene Product pp39
pp39 c-mos
Proto-Oncogene Products c-mos
c-mos Proteins
Proto-Oncogene Proteins mos
pp39(c-mos)
Cytostatic Factor

Cellular proteins encoded by the c-mos genes (GENES, MOS). They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time.


Instruments for RETINOSCOPY that determines the refractive state of the EYE, such as the degree of NEARSIGHTEDNESS; FARSIGHTEDNESS; or ASTIGMATISM. In principle, a retinoscope provides a light source to illuminate the RETINA, and then locates the aerial image of the retina in space to obtain an index of the refractive quality of the patient's lens system.


Osteosarcoma Tumor
Osteogenic Sarcoma
Osteosarcoma
Sarcoma, Osteogenic

A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)


Ventriculography, Cerebral
Cerebral Ventriculography

Radiography of the ventricular system of the brain after injection of air or other contrast medium directly into the cerebral ventricles. It is used also for x-ray computed tomography of the cerebral ventricles.


CD18 Antigen
p150,95 beta-Subunit
Integrin beta2
Antigens, CD18
CD18 Antigens
beta2 Integrin

Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.


Streptococcus Group B
Streptococcus agalactiae

A bacterium which causes mastitis in cattle and occasionally in man.


A 2,4,6-trinitrotoluene, which is an explosive chemical that can cause skin irritation and other toxic consequences.


Thistle, Golden
Scolymus
Goldenthistle
Salsify, Spanish

A plant genus of the family ASTERACEAE with a name that is similar to CYNARA SCOLYMUS. Members contain taraxasteryl acetate.


Bovine Rhinotracheitis Virus, Infectious

Infectious Pustular Vulvovaginitis Virus

Pustular Vulvovaginitis Virus, Infectious

A species of VARICELLOVIRUS that causes INFECTIOUS BOVINE RHINOTRACHEITIS and other associated syndromes in CATTLE.


Pneumology
Pulmonary Medicine
Pneumonology
Pulmonology
Medicine, Pulmonary
Respiratory Medicine

A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.


Parapsoriasis
Digitate Dermatosis
Erythroderma, Maculopapular
Parapsoriasis en Plaques
Parakeratosis Variegata

The term applied to a group of relatively uncommon inflammatory, maculopapular, scaly eruptions of unknown etiology and resistant to conventional treatment. Eruptions are both psoriatic and lichenoid in appearance, but the diseases are distinct from psoriasis, lichen planus, or other recognized dermatoses. Proposed nomenclature divides parapsoriasis into two distinct subgroups, PITYRIASIS LICHENOIDES and parapsoriasis en plaques (small- and large-plaque parapsoriasis).


Budesonide-Formoterol Fumarate Drug Combination

Budesonide, Formoterol Fumarate Drug Combination

Budesonide Formoterol Fumarate Drug Combination

A pharmaceutical preparation of budesonide and formoterol fumarate that is used as an ANTI-ASTHMATIC AGENT and for the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.


Bleeding or escape of blood from a vessel.


Nose Bleed
Nosebleed
Nasal Bleeding
Epistaxis
Nosebleeds


BEETLES in the family Curculionidae and the largest family in the order COLEOPTERA. They have a markedly convex shape and many are considered pests.


Angioleiomyoma
Leiomyoma, Vascular
Angiomyoma

A benign tumor consisting of vascular and smooth muscle elements.


Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant)

A CXC chemokine that is chemotactic for B-LYMPHOCYTES. It has specificity for CXCR5 RECEPTORS.


A genus of facultatively anaerobic, gram-positive bacteria in the family ACTINOMYCETACEAE, order ACTINOMYCETALES. They are obligate parasites of the PHARYNX in humans and farm animals.


Laki-Lorand Factor
Factor Thirteen
Laki Lorand Factor
Blood Coagulation Factor XIII
Factor XIII
Fibrinase
Fibrin Stabilizing Factor
Factor 13
Coagulation Factor XIII
Factor XIII Transamidase

A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.


Acroosteolysis with Osteoporosis and Changes in Skull and Mandible

Rare, autosomal dominant syndrome characterized by ACRO-OSTEOLYSIS, generalized OSTEOPOROSIS, and skull deformations.


Kallikrein I
Serum Kallikrein
Kininogenin
Plasma Kallikrein

A peptidohydrolytic enzyme that is formed from PREKALLIKREIN by FACTOR XIIA. It activates FACTOR XII; FACTOR VII; and PLASMINOGEN. It is selective for both ARGININE and to a lesser extent LYSINE bonds. EC 3.4.21.34.


Multiple Endocrine Neoplasms Type 1
Wermer Syndrome
Neoplasms, Multiple Endocrine Type I
Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasia Type 1
Neoplasms, Multiple Endocrine Type 1
Neoplasia, Multiple Endocrine Type 1

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).


Transcription Factor GATA4
Transcription Factor GATA-4
GATA-4 Transcription Factor
GATA4 Transcription Factor

A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.


The part of the face that is below the eye and to the side of the nose and mouth.


Inflammation, Arachnoid Membrane
Arachnoiditis
Arachnoid Membrane Inflammation

Acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. This term generally refers to a persistent inflammatory process characterized by thickening of the ARACHNOID membrane and dural adhesions. Associated conditions include prior surgery, infections, trauma, SUBARACHNOID HEMORRHAGE, and chemical irritation. Clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (From Joynt, Clinical Neurology, 1997, Ch48, p25)


Failure of the UTERUS to contract with normal strength, duration, and intervals during childbirth (LABOR, OBSTETRIC). It is also called uterine atony.


Pokeweed Mitogen Isolectin
Lectins, Pokeweed
Pokeweed Mitogens
Pokeweed Lectins

Proteins isolated from the roots of the pokeweed, Phytolacca americana, that agglutinate some erythrocytes, stimulate mitosis and antibody synthesis in lymphocytes, and induce activation of plasma cells.


Metabolic X Syndrome
Insulin Resistance Syndrome X
Metabolic Syndrome
Syndrome X, Insulin Resistance
Reaven Syndrome X
Syndrome X, Metabolic
Metabolic Syndrome X
Dysmetabolic Syndrome X
Metabolic Cardiovascular Syndrome

A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.


An enzyme that catalyzes the conversion of prephenate to phenylpyruvate with the elimination of water and carbon dioxide. In the enteric bacteria this enzyme also possesses chorismate mutase activity, thereby catalyzing the first two steps in the biosynthesis of phenylalanine. EC 4.2.1.51.


Smad Proteins, Inhibitory
Inhibitory Smad Proteins
I-Smad Proteins

A sub-family of smad proteins that inhibit cell signaling by RECEPTOR-REGULATED SMAD PROTEINS. They form autoinhibitory feedback loops in the TGF-BETA signaling pathway and mediate signaling cross-talk with other signaling pathways


High-Fructose Maize Syrup
Corn Sugar
Glucose-Fructose Syrup
Isoglucose
Maize Syrup
High Fructose Corn Syrup

Syrup made from corn used widely in foods and beverages as a cheaper alternative sweetener to SUCROSE (common table sugar). It is generated by enzymatic processing of natural corn syrup to produce a liquid most widely composed of 42 or 55% FRUCTOSE, GLUCOSE, and various POLYSACCHARIDES.


Chemistry, Agricultural
Agricultural Chemistry

The science of the chemical composition and reactions of chemicals involved in the production, protection and use of crops and livestock. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


A species of virus (tentatively placed in the genus HEPACIVIRUS) in the family FLAVIVIRIDAE, that was recovered from a tamarin monkey, but may have been of human origin. It causes HEPATITIS in several species of New World monkeys.


Receptors, Erythropoietin
Erythropoietin Receptors
Erythropoietin Receptor

Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behavior of cells.


Endocrine System Diseases
Diseases of Endocrine System
Endocrine Diseases

Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.


Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.


Enhanced Postsurgical Recovery
Enhanced Recovery After Surgery

A protocol of components related to preadmission, preoperative, intraoperative, and postoperative care. The protocol is implemented with the goal of improving patient recovery, facilitating earlier discharge from the hospital, and potentially reducing health care costs without increasing complications or hospital readmissions. The protocol components may contribute to minimizing, and/or improving the response to, physiological stress associated with surgery.


Kardiamed
beta-Acetyldigoxin
Longdigox
Digotab
Novodigal
Digostada
Gladixol N
Acetyldigoxins
digox von ct
alpha-Acetyldigoxin
Stillacor
Desglucolanatosides C
glycotop
Digoxin Didier

Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure.


Fluothane 1,1,1-Trifluoro-2-Chloro-2-Bromoethane Narcotan Ftorotan Halothane

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)


End Plate Potentials
EPSP
Excitatory Postsynaptic Potentials
Excitatory Postsynaptic Currents

Excitatory postsynaptic potentials at the NEUROMUSCULAR JUNCTION.


Myosin LCK
Myosin Regulatory Light-Chain Kinase
Myosin Kinase
Myosin-Light-Chain Kinase

An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.


Parainfluenza Virus 4, Human
Human parainfluenza virus 4

A species of RUBULAVIRUS causing endemic upper respiratory infections in children. It produces only a mild clinical disease and often goes undetected.


Pyrrole containing pigments found in photosynthetic bacteria.


Histidinol Phosphate Phosphatase
Histidinolphosphatase
Histidinol-Phosphatase

An enzyme that catalyzes the hydrolysis of histidinol-phosphate to histidinol. One of the regulatory enzymes in histidine biosynthesis. EC 3.1.3.15.


Hematochezia
Gastrointestinal Hemorrhage
Hemorrhage, Gastrointestinal

The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.


Stomach Dilation
Gastric Dilatation
Gastric Dilation
Stomach Dilatation

Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.


Nonpoint Source Pollution
Non-Point Source Pollution

Water pollution from a variety of diffuse sources carried over or through the ground and into water sources such as LAKES; RIVERS; WETLANDS; coastal waters; and GROUNDWATER. Such diffuse sources include roadways and parking lots (GASOLINE; HEAVY METALS; and motor oil), lawns or agricultural land (excess FERTILIZERS, livestock excrement, and PESTICIDES), landfill seepage, and construction sites (chemicals and trash used in construction processes).


A plant genus of the family ASTERACEAE. Members contain TERPENES and achyrofuran, a prenylated dibenzofuran (BENZOFURANS).


Pituitary Tumor-Transforming Gene Protein

Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.


Duplicating Process
Photocopying
Copying Processes
Copying Process
Duplicating Processes

Reproduction of data in a new location or other destination, leaving the source data unchanged, although the physical form of the result may differ from that of the source.


Rats, Sprague Dawley
Rats, Sprague-Dawley
Rats, Holtzman

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.


Broad-Complex, Tramtrack and Bric a Brac Domain

A homodimerization protein interaction domain occurring at the N terminus of proteins that contain multiple copies of either CYS2-HIS2 ZINC FINGERS or KELCH REPEATS. It is characterized by a tightly intertwined dimer with an extensive hydrophobic interface. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site. Many BTB proteins are transcriptional regulators that are thought to regulate CHROMATIN structure.


Polarcardiography
Electrocardiography, Vector
Vectercardiography
Vectorcardiography
Vector Electrocardiography

Recording of the moment-to-moment electromotive forces of the heart on a plane of the body surface delineated as a vector function of time.


Mouse, MRL lpr
Mouse, Inbred MRL lpr
Mice, MRL lpr
Mice, Inbred MRL lpr

A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.


A plant genus of the family CUPRESSACEAE which produce POLLEN that is a major ALLERGEN.


Intra-atrial Pressure
Atrial Pressure
Intraatrial Pressure

The pressure within the CARDIAC ATRIUM. It can be measured directly by using a pressure catheter (see HEART CATHETERIZATION). It can be also estimated using various imaging techniques or other pressure readings such as PULMONARY CAPILLARY WEDGE PRESSURE (an estimate of left atrial pressure) and CENTRAL VENOUS PRESSURE (an estimate of right atrial pressure).


A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.


ATP Binding Cassette Transporter, Subfamily A, Member 1

ATP-Binding Cassette Sub-Family A Member 1

A superfamily of integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE, characterized by accumulation of cholesteryl ester in various tissues.


Denture, Partial
Bridgework, Dental
Dental Bridgeworks
Bridgeworks, Dental
Dental Bridgework

A denture replacing one or more (but not all) natural teeth. It is supported and retained by underlying tissue and some or all of the remaining teeth.


Public Health Nursing
Nursing, Public Health

A nursing specialty concerned with promoting and protecting the health of populations, using knowledge from nursing, social, and public health sciences to develop local, regional, state, and national health policy and research. It is population-focused and community-oriented, aimed at health promotion and disease prevention through educational, diagnostic, and preventive programs.


Fracture Strength
Bend Strength
Flexural Properties
Flexural Strength
Modulus of Rupture
Flexural Resistance

The maximum MECHANICAL STRESS that a heterogeneous material, subject to a bending load or flexure, can withstand before fracturing.


Severe Dengue
Hemorrhagic Fever, Dengue
Hemorrhagic Dengue
Singapore Hemorrhagic Fever
Philippine Hemorrhagic Fever
Dengue Hemorrhagic Fever
Dengue Shock Syndrome
Thai Hemorrhagic Fever

A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.


Nuclear Receptor Subfamily 4, Group A, Member 2

An orphan nuclear receptor that is found at high levels in BRAIN tissue. The protein is believed to play a role in development and maintenance of NEURONS, particularly dopaminergic neurons.


CYP4 Enzymes
CYP4 Family
Cytochrome P450 Family 4

A cytochrome P450 enzyme family that includes members which function in the metabolism of FATTY ACIDS, especially ARACHIDONIC ACIDS and their derivatives.


Angina Pectoris
Stenocardia
Angor Pectoris

The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.


Pain Receptors
Nociceptors
Nociceptive Neurons
Receptors, Pain

Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.


A type of nuclear polyploidization in which multiple cycles of DNA REPLICATION occur in the absence of CELL DIVISION and result in a POLYPLOID CELL.


Embryo Experimentation
Embryo Research
Embryo Cell Research
Human Embryo Research

Experimentation on, or using the organs or tissues from, a human or other mammalian conceptus during the prenatal stage of development that is characterized by rapid morphological changes and the differentiation of basic structures. In humans, this includes the period from the time of fertilization to the end of the eighth week after fertilization.


Zebrafish Proteins
Brachydanio rerio Proteins
Zebra Danio Proteins
Danio rerio Proteins
Zebra Fish Proteins

Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).


Computer Models
Models, Computer
Computerized Models
In Silico
Computer Simulation

Computer-based representation of physical systems and phenomena such as chemical processes.


A family of very small DNA viruses containing a single molecule of single-stranded DNA and consisting of two subfamilies: PARVOVIRINAE and DENSOVIRINAE. They infect both vertebrates and invertebrates.


APC Resistance
Activated Protein C Resistance

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.


Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate.


Lithobates pipiens
Frog, Leopard
Rana pipiens
Leopard Frog

A highly variable species of the family Ranidae in Canada, the United States and Central America. It is the most widely used Anuran in biomedical research.


A genus of orangutans in the family HOMINIDAE, comprising two species. Among the PRIMATES, the orangutan is second in size only to the gorilla (GORILLA GORILLA).


An inflammatory disease and serious complication of PANCREAS TRANSPLANTATION. It is caused by a premature activation of pancreatic proenzymes leading to autodigestion of the gland and can be attributed to immunological or nonimmunological causes.


Cardiac Septal Defects
Heart Septal Defects

Abnormalities in any part of the HEART SEPTUM resulting in abnormal communication between the left and the right chambers of the heart. The abnormal blood flow inside the heart may be caused by defects in the ATRIAL SEPTUM, the VENTRICULAR SEPTUM, or both.


Receptors, Tumor Necrosis Factor, Type II

Receptors, Tumor Necrosis Factor, Member 1B

Tumor Necrosis Factor Receptor Superfamily, Member 1B

A tumor necrosis factor receptor subtype that is expressed primarily in IMMUNE SYSTEM cells. It has specificity for membrane-bound form of TUMOR NECROSIS FACTORS and mediates intracellular-signaling through TNF RECEPTOR ASSOCIATED FACTORS.


Nurse Patient Relations
Nurse Patient Relationship
Nurse-Patient Relations

Interaction between the patient and nurse.


Heat Shock Protein 72
Heat-Shock Protein p72
Heat Shock Proteins 72
HSP-72 Protein
Hsp72 Protein
HSP70-1 Heat Shock Proteins
HSP72 Heat-Shock Proteins

Stress-inducible members of the heat-shock proteins 70 family. HSP72 heat shock proteins function with other MOLECULAR CHAPERONES to mediate PROTEIN FOLDING and to stabilize pre-existent proteins against aggregation.


Necrotizing Pneumonia
Pneumonia, Necrotizing

Severe complication of pneumonia characterized by liquefaction of lung tissue.


Examinations, Premarital
Premarital Examinations

Medical tests taken by couples planning to be married in order to determine presence of genetic and contagious diseases.


Child, Disabled
Disabled Children
Handicapped Children
Children with Disabilities
Children, Disabled

Children with mental or physical disabilities that interfere with usual activities of daily living and that may require accommodation or intervention.


Gram-Positive Endospore-Forming Rods
Gram Positive Endospore Forming Rods

Rod-shaped bacteria that form endospores and are gram-positive. Representative genera include BACILLUS and CLOSTRIDIUM.


Severe acute respiratory syndrome-related coronavirus

A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.


Biological Coevolution
Biological Co-Evolution

The process of reciprocal evolutionary change occurring between pairs of species or among groups of species as they interact.


Any waste product generated by a dental office, surgery, clinic, or laboratory including amalgams, saliva, and rinse water.


Precautions, Universal
Universal Precautions

Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.


Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.


Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.


Uropathogenic E. coli
Uropathogenic Escherichia coli

Strains of Escherichia coli that preferentially grow and persist within the urinary tract. They exhibit certain virulence factors and infection pathways that cause URINARY TRACT INFECTIONS.


Postcoital Contraceptive Agents, Synthetic

Contraceptive Agents, Postcoital, Synthetic

Synthetic Postcoital Contraceptive Agents

Postcoital contraceptives which owe their effectiveness to synthetic preparations.


Models, Educational
Educational Models
Instructional Models

Theoretical models which propose methods of learning or teaching as a basis or adjunct to changes in attitude or behavior. These educational interventions are usually applied in the fields of health and patient education but are not restricted to patient care.


Vascular Endothelial Junctional Adhesion Molecule

A junctional adhesion molecule subtype that is localized to high endothelial VENULES, heart ENDOTHELIUM, TROPHOBLASTS of the PLANCENTA, and in the ENDOTHELIUM of ARTERIOLES.


Injuries, Nervous System
Craniocervical Injuries
Axonotmesis
Nervous System Injuries
Neurotmesis
Trauma, Nervous System

Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.


Adenosine-Diphosphate-Ribose, O-Acetyl-
O-Acetyl-Adenosine-Diphosphate-Ribose
AADPR
O-Acetyl-ADP-Ribose

An acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction.


Dental Libraries
Libraries, Dental
Library, Dental
Dental Library

Collections of information resources relevant to DENTISTRY.


Rare autosomal dominant disorder of the hair shaft. The clinical features of the disease include HYPOTRICHOSIS, dry, and/or brittle hair, with varying degrees of ALOPECIA. Mutations in the hair-specific keratin genes KRTHB1, KRTHB3, or KRTHB6 are associated with monilethrix. Autosomal recessive monilethrix with limited HYPOTRICHOSIS are also known. Mutations in Dsg4, Liph, and P2ry5 protein genes are associated with the recessive form of monilethrix.


ATP Binding Cassette Transporter, Subfamily G, Member 8

ATP Binding Cassette Transporter, Sub-Family G, Member 8

ATP-binding cassette transporter, sub-family G protein that functions as a heterodimer with ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY G, MEMBER 5 in the selective transport of DIETARY CHOLESTEROL and PHYTOSTEROLS into and export out of ENTEROCYTES. It also functions in selective sterol excretion by the liver into bile.


beta-Glucocerebrosidase
Glucosyl Ceramidase
Acid beta-Glucosidase
Glucosylceramidase
Glucocerebrosidase
Glucocerebroside beta-Glucosidase
Glucosylceramide beta-Glucosidase
Glucosylsphingosine Glucosyl Hydrolase

A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.


Receptors, Granulocyte Colony-Stimulating Factor

Granulocyte Colony-Stimulating Factor Receptors

Receptor, Granulocyte Colony-Stimulating Factor

Receptors that bind and internalize GRANULOCYTE COLONY-STIMULATING FACTOR. Their MW is believed to be 150 kD. These receptors are found mainly on a subset of myelomonocytic cells.


A phylum of unicellular flagellates of ancient eukaryotic lineage with unclear taxonomy. They lack a CELL WALL but are covered by a proteinaceous flexible coat, the pellicle, that allows the cell to change shape. Historically some authorities considered them to be an order of protozoa and others classed them as ALGAE (some members have CHLOROPLASTS and some don't).


Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.


Os Hamatum
Hook of the Hamate
Hamate Bone

A carpal bone located between the CAPITATE BONE and the TRIQUETRUM BONE. The hamate has a prominent process that projects anteriorly.


Chromatography, Liquid
Liquid Chromatography

Chromatographic techniques in which the mobile phase is a liquid.


Betazole
Betazole Dihydrochloride
Histalog
Betazole Monohydrochloride
Lilly 96791
Ametazole

A histamine H2 agonist used clinically to test gastric secretory function.


One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.


A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.


Racemases
Epimerases and Racemases
Epimerases
Racemases and Epimerases

Enzymes that catalyze inversion of the configuration around an asymmetric carbon in a substrate having one (racemase) or more (epimerase) center(s) of asymmetry. (Dorland, 28th ed) EC 5.1.


(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.


Directed Donation
Directed Tissue Donation
Directed Organ Donation
Directed Gamete Donation

Gamete donation intended for a designated recipient.


A member of the alpha-globin family. In humans, zeta-globin is encoded in the alpha-globin gene cluster located on CHROMOSOME 16. Two zeta-globin chains combine with two EPSILON GLOBIN chains to form the embryonic HEMOGLOBIN Gower 1.


A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.


Fissures, Dental
Fissure, Dental
Dental Fissures
Dental Fissure

Deep grooves or clefts in the surface of teeth equivalent to class 1 cavities in Black's classification of dental caries.


RNA-binding proteins that facilitate or inhibit RNA SPLICING.


Pulmonary Surfactant
Surfactant, Pulmonary
Surfactants, Pulmonary
Pulmonary Surfactants

Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.


Infections, Bifidobacteriales
Bifidobacteriales Infections

Infections with BACTERIA of the order Bifidobacteriales. This includes infections in the genera BIFIDOBACTERIUM and GARDNERELLA, in the family Bifidobacteriaceae.


Crystallography, X Ray
Crystallography, Xray
X Ray Crystallography
X-Ray Crystallography
Xray Crystallography
Crystallography, X-Ray

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)


A rare type of abnormal pregnancy in which EMBRYO IMPLANTATION occurs at a lateral angle of the UTERUS, medial to the uterotubal junction and the ROUND LIGAMENT OF UTERUS.


Excessive shedding of dry scaly material from the scalp in humans.


Computer systems utilized as adjuncts in the treatment of disease.


A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.


Teichomycin A2
Teicoplanin
Targocid
Teichomycin

Lipoglycopeptide antibiotic from Actinoplanes teichomyceticus active against gram-positive bacteria. It consists of five major components each with a different fatty acid moiety.


Cytochromes f
Apocytochrome f
Cytochrome f

Cytochromes f are found as components of the CYTOCHROME B6F COMPLEX. They play important role in the transfer of electrons from PHOTOSYSTEM I to PHOTOSYSTEM II.


Monooxygenases
Mixed Function Oxygenases
Mixed Function Oxidases
Hydroxylases

Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.


Receptors, Adiponectin
Adiponectin Receptors
Adiponectin Receptor

Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.


Gene Expression Regulation, Fungal
Regulation of Gene Expression, Fungal
Regulation, Gene Expression, Fungal
Fungal Gene Expression Regulation

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.


Membrane-Type Matrix Metalloproteinase 2

A transmembrane domain-containing matrix metalloproteinase that plays a role in the cleavage of proteins in the pericellular environment. It is synthesized as an inactive zymogen that is activated by the action of ENDOPEPTIDASES such as MATRIX METALLOPROTEINASE 14.


Aventyl
Nortriptyline Hydrochloride
Nortriptyline
Allegron
Nortrilen
PMS-Nortriptyline
Novo-Nortriptyline
Desmethylamitriptylin
Desitriptyline
ratio-Nortriptyline
Gen-Nortriptyline
Paxtibi
Norfenazin
Apo-Nortriptyline
Nu-Nortriptyline
Pamelor

A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.


Licensed Vocational Nurses
Licensed Practical Nurses

Health personnel who do not hold professional degrees or credentials, but have completed training and are licensed to provide routine patient care under the direction of registered nurses and physicians.


Vagotomy, Parietal Cell
Vagotomy, Selective Proximal
Vagotomy, Proximal Gastric
Vagotomy, Highly Selective

Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. Since the procedure leaves the vagal branches to the antrum and PYLORUS intact, it circumvents gastric drainage required with truncal vagotomy techniques.


Planet Mercury
Mercury, Planet
Mercury (Planet)

The first planet in order from the sun. It has no known natural satellites. It is one of the four inner or terrestrial planets of the solar system.


G Protein Subunit alpha I2
Galphai2 Protein
GTP-Binding Protein alpha Subunit, Gi2
Gi2-alpha Protein
Galpha(i2) Protein

A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SURFACE RECEPTORS, has been implicated in INTERLEUKIN-12 production, and may play a role in INFLAMMATORY BOWEL DISEASES.


A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.


Phosphogluconate Dehydrogenase
6-Phosphogluconate Dehydrogenase

An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.


T Cell-Specific Transcription Factor 1-alpha

A T-cell factor that plays an essential role in EMBRYONIC DEVELOPMENT.


Receptors, Tumor Necrosis Factor, Member 18

Tumor Necrosis Factor Receptor Superfamily, Member 18

A member of the TNF receptor family that was initially identified as a DEXAMETHASONE-induced protein from a T-CELL line. It may play a role in regulating APOPTOSIS and modulating immune response by T-lymphocytes. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Lipotropin beta-Lipotrophin beta-LPH Adipozin beta-Lipotropin

A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.


Percutaneous Coronary Intervention
Percutaneous Coronary Revascularization

A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.


Surgical removal of the SYNOVIAL MEMBRANE.


Amino Acid Transport System ASC Proteins

A ubiquitous sodium-dependent neutral amino acid transporter. The preferred substrates for this transporter system include ALANINE; SERINE; and CYSTEINE.


Dietary Sugars
Dietary Sugar
Sugars, Dietary

MONOSACCHARIDES and DISACCHARIDES present in food, such as those present in fruits and vegetables and milk products, or those added to food such as DIETARY SUCROSE (table sugar) or HIGH FRUCTOSE CORN SYRUP.


The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.


Leukemia, Myeloid, Acute, M4
Myelomonocytic Leukemia, Acute
Leukemia, Myelomonocytic, Acute
Myeloid Leukemia, Acute, M4
Leukemia, Myeloid, Naegeli-Type
Myeloid Leukemia, Naegeli-Type

A pediatric acute myeloid leukemia involving both myeloid and monocytoid precursors. At least 20% of non-erythroid cells are of monocytic origin.


A mitosporic fungal genus with many reported ascomycetous teleomorphs. Cephalosporin antibiotics are derived from this genus.


A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)


Neurotoxin Diseases
Neurotoxin Disorders
Poisoning, Nervous System
Nervous System Poisoning
Neurotoxic Disorders
Neurotoxicity Syndromes
Encephalopathy, Toxic
Toxic Encephalitis

Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.


Deformities of the SPINE characterized by an exaggerated convexity of the vertebral column. The forward bending of the thoracic region usually is more than 40 degrees. This deformity sometimes is called round back or hunchback.


Kedacillin I.M.
Sulbenicillin
Sulfobenzylpenicillin
Disodium alpha-Sulfobenzylpenicillin


The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)


Rats, Transgenic
Rat, Transgenic
Transgenic Rats

Laboratory rats that have been produced from a genetically manipulated rat EGG or rat EMBRYO, MAMMALIAN. They contain genes from another species.


A diet that consists mainly of foods with a high content of protein and limited amounts of CARBOHYDRATES.


Cell Cycle Proteins
Cell Division Cycle Proteins
Cell-Cycle Regulatory Proteins
cdc Proteins

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.


A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.


nef Gene Products, Human Immunodeficiency Virus

nef Protein, Human Immunodeficiency Virus

Proteins encoded by the NEF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.


Amerinds, South American
Indians, South American

Individual members of South American ethnic groups with historic ancestral origins in Asia.


Glycoprotein from Sendai, para-influenza, Newcastle Disease, and other viruses that participates in binding the virus to cell-surface receptors. The HN protein possesses both hemagglutinin and neuraminidase activity.


Bioengineering
Biological Engineering
Bio-Engineering
Bio engineering

The application of engineering principles and methods to living organisms or biological systems.


Familial Restrictive Cardiomyopathy
Cardiomyopathy, Restrictive

A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.


FCS Syndrome
Costello Syndrome
Faciocutaneoskeletal Syndrome

Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).


HLA Class I Histocompatibility Antigen, B-51 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*51 allele family.


The study of ENVIRONMENTAL POLLUTION and the toxic effects of ENVIRONMENTAL POLLUTANTS on the ECOSYSTEM. The term was coined by Truhaut in 1969.


Mechanistic Target of Rapamycin Complex 1

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.


A phylum of fungi comprising minute intracellular PARASITES with FUNGAL SPORES of unicellular origin. It has two classes: Rudimicrosporea and MICROSPOREA.


Glutathione Peroxidase
Cytosolic Glutathione Peroxidase
Selenoglutathione Peroxidase
Glutathione Lipoperoxidase

An enzyme catalyzing the oxidation of 2 moles of GLUTATHIONE in the presence of HYDROGEN PEROXIDE to yield oxidized glutathione and water.


Renal Tubule Necrosis
Renal Cortical Necrosis
Glomerular Necrosis
Kidney Cortex Necrosis

Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.


Healthcare CRM
Healthcare Crew Resource Management
Crisis Resource Management, Healthcare
Healthcare Crisis Resource Management
Crew Resource Management, Healthcare

A range of healthcare related training designed to reduce MEDICAL ERRORS and improve PATIENT SAFETY by emphasizing TEAMWORK and human factors (see HUMAN ENGINEERING).


Herniation of Meninges
Meningocele, Traumatic
Rudimentary Meningocele
Meningeal Herniation
Meningocele
Acquired Meningocele

A congenital or acquired protrusion of the meninges, unaccompanied by neural tissue, through a bony defect in the skull or vertebral column.


SV 40 Virus
SV40 Virus
Polyomavirus macacae
Simian virus 40
Vacuolating Agent

A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.


Repifermin
Fibroblast Growth Factor 10
Keratinocyte Growth Factor 2

A fibroblast growth factor that is a mitogen for KERATINOCYTES. It activates FIBROBLAST GROWTH FACTOR RECEPTOR 2B and is involved in LUNG and limb development.


beta-MSH
beta-Melanotropin
beta-Melanocyte-Stimulating Hormone
Melanocyte-Stimulating Hormone, beta
MSH, beta
beta Intermedin

An 18-amino acid peptide that is the C-terminal fragment of gamma-lipotropin which is the N-terminal fragment of BETA-LIPOTROPIN. Beta-MSH is shown to regulate skin pigmentation, steroid production, and feeding.


Sucrase Isomaltase Complex
Sucrase-Isomaltase Complex

An enzyme complex found in the brush border membranes of the small intestine. It is believed to be an enzyme complex with different catalytic sites. Its absence is manifested by an inherited disease called sucrase-isomaltase deficiency.


Benzimidazole antiplatyhelmintic agent that is used for the treatment of FASCIOLIASIS and PARAGONIMIASIS.


Receptors, Interleukin Common gamma Chain

Interleukin Receptor Common gamma Subunit

An interleukin receptor subunit that was originally discovered as a component of the INTERLEUKIN 2 RECEPTOR. It was subsequently found to be a component of several other receptors including the INTERLEUKIN 4 RECEPTOR, the INTERLEUKIN 7 RECEPTOR, the INTERLEUKIN-9 RECEPTOR, the INTERLEUKIN-15 RECEPTOR, and the INTERLEUKIN-21 RECEPTOR. Mutations in the gene for the interleukin receptor common gamma chain have been associated with X-LINKED COMBINED IMMUNODEFICIENCY DISEASES.


A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.


Hutchinson-Gilford Syndrome
Hutchinson-Gilford Progeria Syndrome
Hutchinson Gilford Progeria Syndrome
Progeria

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.


Interleukin-12 Receptor p35 Subunit
Interleukin-12 Receptor beta 2 Chain
Interleukin-12 Receptor beta 2 Subunit

A subunit of the interleukin-12 receptor. It plays a role in receptor signaling by associating with JANUS KINASE 2.


Neonatal Intensive Care
Infant, Newborn, Intensive Care
Intensive Care, Neonatal

Continuous care and monitoring of newborn infants with life-threatening conditions, in any setting.


A class of amino acids characterized by a closed ring structure.


Tribulus terrestris
Puncture Vine
Tribulus
Goathead

A plant genus of the family ZYGOPHYLLACEAE. Members contain steroidal saponins. Ingestion by grazing animals causes PHOTOSENSITIVITY DISORDERS called geeldikkop (yellow thick head) in South Africa.


Empyema, Pleural
Pyothorax
Empyema, Thoracic

Suppurative inflammation of the pleural space.


N-Terminal Acetyltransferase Type E
NatE N-Terminal Acetyltransferase
N-Terminal Acetyltransferase E

An N-terminal acetyltransferase subtype that consists of the Naa50p catalytic subunit, and the Naa10p and Naa15p auxiliary subunits. It has specificity for the N-terminal METHIONINE of peptides where the next amino acid in the chain is hydrophobic.


Tissue-Engineered Vascular Graft
Blood Vessel Prosthesis
Blood Vessel Prostheses
Vascular Prosthesis

Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.


U. S. Civil War, 1861-1865
War Between the States
War of the Rebellion
War of Secession
American Civil War

1861-1865 conflict between the Union (Northern states) and the 11 Southern states that seceded and were organized as the Confederate States of America.


TRALI
Transfusion-Related Acute Lung Injury
Acute Lung Injury, Transfusion-Related

A rare but serious transfusion-related reaction in which fluid builds up in the lungs unrelated to excessively high infusion rate and/or volume (TRANSFUSION-ASSOCIATED CIRCULATORY OVERLOAD). Signs of Transfusion-Related Acute Lung Injury include pulmonary secretions; hypotension; fever; DYSPNEA; TACHYPNEA; TACHYCARDIA; and CYANOSIS.


Pineal Body
Pineal Gland
Epiphysis Cerebri
Corpus Pineale

A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.


Nidation
Ovum Implantation
Implantation, Blastocyst
Embryo Implantation
Blastocyst Implantation
Decidual Cell Reaction

Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage.


U2AF 65
Splicing Factor U2AF
U2AF Splicing Factor
U2AF(65)

An RNA splicing factor that performs a critical function in both constitutive and enhancer-dependent RNA SPLICING. It recruits RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR to the splice site and mediates interactions between it, the RNA molecule, and other splicing factors for accurate 3'-splice site selection.


Protein Tyrosine Phosphatase, Non-Receptor Type 4

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an amino-terminal FERM domain, an intervening region containing one or more PDZ domains, and a carboxyl-terminal phosphatase domain. The subtype was originally identified in a cell line derived from MEGAKARYOCYTES.


Amygdalin Laetrile Neoamygdalin Amygdaloside Mandelonitrile-beta-Gentiobioside

A cyanogenic glycoside found in the seeds of Rosaceae.


Aspartic Acid Proteinases
Aspartyl Proteases
Aspartic Proteinases
Aspartic Acid Proteases
Aspartyl Proteinases

A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.


A class in the phylum MOLLUSCA comprised of flattened, elongated marine mollusks, commonly called chitons. They are unique in that they possess seven or eight separate shell plates.