Geoscience
Earth Science
Geosciences
Earth Sciences

Fields of science encompassing studies and research from the disciplines of PHYSICS; CHEMISTRY; BIOLOGICAL SCIENCES; and MATHEMATICS; that are related to the planet EARTH. Subfields include atmospheric chemistry; CLIMATOLOGY; ENVIRONMENTAL SCIENCES; GEOGRAPHY; GEOLOGY; geophysics; METEOROLOGY; OCEANOGRAPHY; PALEONTOLOGY; mineralogy; and seismology.


Female Sterilization, Voluntary
Male Sterilization
Female Sterilization
Male Sterilization, Voluntary
Sterilization, Reproductive
Voluntary Sterilization
Reproductive Sterilization

Procedures to block or remove all or part of the genital tract for the purpose of rendering individuals sterile, incapable of reproduction. Surgical sterilization procedures are the most commonly used. There are also sterilization procedures involving chemical or physical means.


2,2,2-Trifluoroethanol
Trifluoroethyl Alcohol
Trifluoroethanol

A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications.


Receptors, Albumin
Albumin Receptor
Albumin Receptors

Cell surface proteins that bind albumin with high affinity and trigger intracellular changes influencing the behavior of cells.


Hemorrhage, Peptic Ulcer
Peptic Ulcer Hemorrhage

Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.


Pheromones, Sexual
Sex Attractants
Copulins
Sex Attractant
Sex Pheromone
Sex Pheromones

Pheromones that elicit sexual attraction or mating behavior usually in members of the opposite sex in the same species.


Number of deaths of children between one year of age to 12 years of age in a given population.


Endoprotease, ATP-Dependent
ATP-Dependent Endoprotease
ATP-Dependent Endoproteases
ATP-Dependent Endopeptidases

Endoproteases that contain proteolytic core domains and ATPase-containing regulatory domains.


Herpesvirus Suis
Suid Herpesvirus 1
Swine Herpesvirus 1
Pseudorabies Virus
Aujeszky's Disease Virus
Herpesvirus 1 (alpha), Suid
Herpesvirus 1, Suid
Aujeszky Disease Virus

A species of VARICELLOVIRUS producing a respiratory infection (PSEUDORABIES) in swine, its natural host. It also produces an usually fatal ENCEPHALOMYELITIS in cattle, sheep, dogs, cats, foxes, and mink.


Hepatitis D Antigen
Hepatitis delta Antigens
Hepatitis D Antigens
delta Antigen
HDAg

Antigens produced by various strains of HEPATITIS D VIRUS.


Vaginal Bleeding
Uterine Bleeding
Uterine Hemorrhage
Hemorrhage, Uterine

Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.


Skin Ointment
Unguents
Pastes
Ointments
Salves

Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.


The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).


Quinone Outside Inhibitors
Strobilurin
Strobilurins

Benzene or pyrimidine derivatives of methacrylic acid that block the Qo site of CYTOCHROME B. They are widely used as agricultural fungicides.


Platelet-Derived Growth Factor BB, Recombinant

Recombinant Platelet-Derived Growth Factor BB

A recombinant human platelet-derived growth factor B-chain dimer used to promote WOUND HEALING by stimulating PHYSIOLOGIC ANGIOGENESIS.


Lymph Node Syndrome, Mucocutaneous
Kawasaki Syndrome
Kawasaki Disease
Mucocutaneous Lymph Node Syndrome

An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.


Interruption or suppression of the expression of a gene at transcriptional or translational levels.


A family of double-stranded DNA viruses infecting mammals (including humans), birds and insects. There are two subfamilies: CHORDOPOXVIRINAE, poxviruses of vertebrates, and ENTOMOPOXVIRINAE, poxviruses of insects.


L-Serine Dehydratase
Serine Dehydratase
Serine Deaminase
L-Serine Ammonia-Lyase
Serine-Threonine Dehydratase

A PYRIDOXAL-phosphate containing enzyme that catalyzes the dehydration and deamination of L-serine to form pyruvate. This enzyme was formerly listed as EC 4.2.1.13.


c-raf Kinases
cRaf1 Kinase
Kinase p74(raf-1)
Proto-Oncogene Protein c-raf
raf-1 Kinase
Kinase Raf-1
c-raf Proteins
Proto-Oncogene Proteins c-raf

A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.


Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein

A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.


A diet which is devoid of GLUTENS from WHEAT; BARLEY; RYE; and other wheat-related varieties. The diet is designed to reduce exposure to those proteins in gluten that trigger INFLAMMATION of the small intestinal mucosa in patients with CELIAC DISEASE.


Tumor Suppressor in Lung Cancer 1 Protein

A cell adhesion molecule that contains extracellular immunoglobulin V and C2 domains. It mediates homophilic and heterophilic cell-cell adhesion independently of calcium, and acts as a tumor suppressor in NON-SMALL-CELL LUNG CANCER (NSCLC) cells. Its interaction with NATURAL KILLER CELLS is important for their cytotoxicity and its expression by MAST CELLS plays a role in their interaction with neurons; it may also function in synapse assembly, nerve growth and differentiation.


Qualified medical professionals who specialize in surgical treatment of diseases of the BRAIN and other parts of the NERVOUS SYSTEM.


Salmonella Food Poisoning
Food Poisoning, Salmonella

Poisoning caused by ingestion of food harboring species of SALMONELLA. Conditions of raising, shipping, slaughtering, and marketing of domestic animals contribute to the spread of this bacterium in the food supply.


Submandibular Space Infection
Ludwig's Angina

Severe cellulitis of the submaxillary space with secondary involvement of the perimandibular spaces. It usually results from infection in the lower molar area or from an infection following a penetrating injury to the MOUTH FLOOR.


L3T4 Antigens
Antigens, Differentiation, T Lymphocyte
Differentiation Antigens, T-Cell
T-Cell Differentiation Antigens
Antigens, Differentiation, T-Cell
Leu Antigens, T-Lymphocyte
Antigens, Differentiation, T-Lymphocyte
Differentiation Antigens, T Lymphocyte
T-Lymphocyte Differentiation Antigens
T6 Antigens

Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.


Chlamydia pneumoniae
Chlamydophila pneumoniae

A species of CHLAMYDOPHILA that causes acute respiratory infection, especially atypical pneumonia, in humans, horses, and koalas.


Wounds and Injury
Injuries and Wounds
Research-Related Injuries
Wounds, Injury
Injuries, Wounds
Wounds
Wounds and Injuries
Trauma
Injuries

Injuries that occur as a result of participation in a research study.


Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.


Charges, Hospital
Hospital Charge
Hospital Charges
Charge, Hospital

The prices a hospital sets for its services. HOSPITAL COSTS (the direct and indirect expenses incurred by the hospital in providing the services) are one factor in the determination of hospital charges. Other factors may include, for example, profits, competition, and the necessity of recouping the costs of uncompensated care.


Autophagy-Related Protein 5
ATG5 Protein
Autophagy-Related 5 Protein
Autophagy Protein-5
ATG-5 Protein
Apoptosis-Specific Protein

An autophagy-related protein that functions in AUTOPHAGOSOME biogenesis. It is conjugated to the ATG12 PROTEIN via a process that is similar to UBIQUITINATION and involves the ATG7 PROTEIN and ATG10 enzyme. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme and is required for the localization of ATG8 PROTEINS to AUTOPHAGOSOME vesicle membranes and modification of membrane lipids.


4-Pyridoxylic Acid
Pyridoxinecarboxylic Acid
4-Pyridoxinic Acid
4-Pyridoxic Acid
Pyridoxic Acid

The catabolic product of most of VITAMIN B 6; (PYRIDOXINE; PYRIDOXAL; and PYRIDOXAMINE) which is excreted in the urine.


Uterine Contraction
Myometrial Contraction


The application of a caustic substance, a hot instrument, an electric current, or other agent to control bleeding while removing or destroying tissue.


Meshes, Surgical
Surgical Mesh
Mesh, Surgical
Surgical Meshes

Any woven or knit material of open texture used in surgery for the repair, reconstruction, or substitution of tissue. The mesh is usually a synthetic fabric made of various polymers. It is occasionally made of metal.


Trichinellosis
Trichinosis
Trichinelliasis
Human Trichinellosis

An infection with TRICHINELLA. It is caused by eating raw or undercooked meat that is infected with larvae of nematode worms TRICHINELLA genus. All members of the TRICHINELLA genus can infect human in addition to TRICHINELLA SPIRALIS, the traditional etiological agent. It is distributed throughout much of the world and is re-emerging in some parts as a public health hazard and a food safety problem.


Photoreceptors, Microbial
Photoreceptor, Microbial

Light absorbing proteins and protein prosthetic groups found in certain microorganisms. Some microbial photoreceptors initiate specific chemical reactions which signal a change in the environment, while others generate energy by pumping specific ions across a cellular membrane.


Dermatologic Agent
Dermatologic Agents
Dermatological Agents
Agents, Dermatologic
Agent, Dermatologic
Agent, Dermatological

Drugs used to treat or prevent skin disorders or for the routine care of skin.


Colamine 2-Aminoethanol Monoethanolamine Ethanolamine

A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.


Type V Secretion Systems
Bacterial Secretion System, Type V
Two-Partner Secretion Systems
Type 5 Secretion System
Autotransporters
Type V Secretion System
Type 5 Secretion Systems

Subtypes of type V secretion systems that contain both a translocator domain and a passenger domain in a single polypeptide. After the passenger domain is transported to the extracellular millieu it is cleaved off as the mature secreted protein.


Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.


An interdisciplinary study of the microstructure and composition of various materials such as metals, semiconductors, ceramics, and polymers, in relation to their macromolecular physical and chemical properties. Materials science enables the custom creation of new materials with specific properties and uses.


Platelet-Derived Growth Factor beta Receptor

Receptor, Platelet-Derived Growth Factor beta

A PDGF receptor that binds specifically to the PDGF-B chain. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.


Warts, Venereal
Venereal Warts
Genital Warts
Warts, Genital
Condylomata Acuminata

Sexually transmitted form of anogenital warty growth caused by the human papillomaviruses.


Actinidia
Actinidia deliciosa
Kiwi Plant

Actinidia deliciosa (A. Chev.) C. F. Liang & A. R. Ferguson = Actinidia chinensis P.


Retinoblastoma Protein Binding Proteins
Retinoblastoma Binding Proteins
RBBP Proteins

A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression.


Inhibitor, Coagulation Factor, Blood
Inhibitors, Coagulation Factor, Blood
Blood Coagulation Factor Inhibitors
Inhibitors, Blood Coagulation Factor
Inhibitor, Blood Coagulation Factor

Substances, usually endogenous, that act as inhibitors of blood coagulation. They may affect one or multiple enzymes throughout the process. As a group, they also inhibit enzymes involved in processes other than blood coagulation, such as those from the complement system, fibrinolytic enzyme system, blood cells, and bacteria.


Enterobacteria phage IKe
Phage IKe
IKe Phage
Bacteriophage IKe

A species of filamentous phage in the genus INOVIRUS, family INOVIRIDAE. They are specific for enterobacteria that contain an IncN plasmid.


GM(2) Activating Protein
G(M2) Activator Protein
GM2 Activator Protein
Hexosaminidase Activator

An essential cofactor for the degradation of G(M2)GANGLIOSIDE by lysosomal BETA-N-ACETYLHEXOSAMINIDASES. Genetic mutations resulting in loss of G(M2) activator protein are one of the causes of TAY-SACHS DISEASE, AB VARIANT.


Chronic Wasting Disease
Wasting Disease, Chronic

A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS).


Macrophages, Peritoneal
Peritoneal Macrophages

Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.


Catecholamine Plasma Membrane Transport Proteins

Catecholamine Plasma Membrane Transporter Proteins

Catecholamine Plasma Membrane Transporters

Neurotransmitter Transport Proteins, Catecholamine-Specific

A group of membrane transport proteins that transport biogenic amine derivatives of catechol across the PLASMA MEMBRANE. Catecholamine plasma membrane transporter proteins regulate neural transmission as well as catecholamine metabolism and recycling.


A groin hernia occurring inferior to the inguinal ligament and medial to the FEMORAL VEIN and FEMORAL ARTERY. The femoral hernia sac has a small neck but may enlarge considerably when it enters the subcutaneous tissue of the thigh. It is caused by defects in the ABDOMINAL WALL.


Neuromuscular Junction
Myoneural Junction
Nerve-Muscle Preparation

The synapse between a neuron and a muscle.


Cutaneous Leukocytoclastic Angiitis
Allergic Cutaneous Vasculitis
Cutaneous Leukocytoclastic Vasculitis
Hypersensitivity Angiitis
Cutaneous Allergic Vasculitis
Allergic Cutaneous Angiitis
Vasculitis, Allergic Cutaneous
Angiitis, Hypersensitivity
Vasculitis, Leukocytoclastic, Cutaneous
Angiitis, Allergic Cutaneous
Vasculitis, Hypersensitivity
Hypersensitivity Vasculitis

Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.


The time frame after a meal or FOOD INTAKE.


Gap Junction beta-6 Protein
GJB6 Protein
Connexin 30
CX30 Channels

A gap junction beta subunit that forms heteromeric hemichannels when paired with alpha subunits such as connexin-40 or CONNEXIN 43. Mutations in the connexin 30 gene (GJ6B) are associated with CLOUSTON'S SYNDROME and some hereditary forms of deafness.


Non-Histone Chromosomal Phosphoproteins
Chromosomal Proteins, Non Histone
Chromosomal Proteins, Non-Histone
Non-Histone Chromosomal Proteins
Chromosomal Proteins, Nonhistone

Nucleoproteins, which in contrast to HISTONES, are acid insoluble. They are involved in chromosomal functions; e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens.


Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)


Neuromedin K
Neurokinin beta
Neurokinin B

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.


A group of inherited metabolic disorders involving the enzymes responsible for the synthesis and degradation of glycogen. In some patients, prominent liver involvement is presented. In others, more generalized storage of glycogen occurs, sometimes with prominent cardiac involvement.


Slit Lamp Biomicroscope
Slit Lamp
Gullstrand's Slit Lamp

A microscope with a light source that can be projected into a linear beam. It allows cross-sectional viewing of the AQUEOUS HUMOR; CONJUNCTEIVA; CORNEA; EYELIDS; IRIS; and lens (see LENS, EYE) of the eye.


Persons skilled and/or qualified to operate an aircraft or ship.


High Mobility Group Nucleosomal Binding Proteins

A family of HIGH MOBILITY GROUP PROTEINS that bind to NUCLEOSOMES.


Calcium Magnesium Adenosine Triphosphatase

Adenosine Triphosphatase, Calcium, Magnesium

An enzyme that catalyzes the hydrolysis of ATP and is activated by millimolar concentrations of either Ca(2+) or Mg(2+). Unlike CA(2+)-TRANSPORTING ATPASE it does not require the second divalent cation for its activity, and is not sensitive to orthovanadate. (Prog Biophys Mol Biol 1988;52(1):1). A subgroup of EC 3.6.1.3.


A homotypic protein interaction module of the death domain superfamily that is composed of a bundle of six alpha-helices. The death effector domain shares sequence and structural similarities with the DEATH DOMAIN and CASPASE RECRUITMENT DOMAIN. It occurs in many proteins with essential functions in APOPTOSIS.


Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.


Glial Intermediate Filament Protein
Glial Fibrillary Acid Protein
Astroprotein
GFA-Protein
Glial Fibrillary Acidic Protein

An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.


Diabetic Ketosis
Diabetic Ketoacidosis
Acidosis, Diabetic
Ketosis, Diabetic
Ketoacidosis, Diabetic
Diabetic Acidosis

A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by KETOSIS; DEHYDRATION; and depressed consciousness leading to COMA.


Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.


Translation Initiation Factors, Eukaryotic

Peptide initiation factors from eukaryotic organisms. Over twelve factors are involved in PEPTIDE CHAIN INITIATION, TRANSLATIONAL in eukaryotic cells. Many of these factors play a role in controlling the rate of MRNA TRANSLATION.


Ventral Pallidum
Basal Forebrain Area
Pars Basalis Telencephali
Basal Forebrain

The region of the telencephalon located rostral and ventral to the STRIATUM comprising AMYGDALA; SEPTAL NUCLEI; SUBSTANTIA INNOMINATA and ventral pallidum.


Unsafe Sex
High-Risk Sex
Unprotected Sex

Sexual behaviors which are high-risk for contracting SEXUALLY TRANSMITTED DISEASES or for producing PREGNANCY.


Procedures to restore vertebrae to their original shape following vertebral compression fractures by inflating a balloon inserted into the vertebrae, followed by removal of the balloon and injection of BONE CEMENTS to fill the cavity.


Nephroblastoma
Wilms Tumor 1
Bilateral Wilms Tumor
Wilms' Tumor
Wilms Tumor

A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.


Limb-Girdle Muscular Dystrophies
Myopathic Limb-Girdle Syndrome
Muscular Dystrophies, Limb-Girdle
Limb-Girdle Muscular Dystrophy
Limb-Girdle Syndrome
Muscular Dystrophy, Limb-Girdle

A heterogenous group of inherited muscular dystrophy that can be autosomal dominant or autosomal recessive. There are many forms (called LGMDs) involving genes encoding muscle membrane proteins such as the sarcoglycan (SARCOGLYCANS) complex that interacts with DYSTROPHIN. The disease is characterized by progressing wasting and weakness of the proximal muscles of arms and legs around the HIPS and SHOULDERS (the pelvic and shoulder girdles).


A fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS.


High Frequency Jet Ventilation
Ventilation, High Frequency Jet
High-Frequency Jet Ventilation

Respiratory support system used primarily with rates of about 100 to 200/min with volumes of from about one to three times predicted anatomic dead space. Used to treat respiratory failure and maintain ventilation under severe circumstances.


Trivalent Equine Botulinum Antitoxin
Botulism Antitoxin
Botulinum Antitoxin

Antiserum given therapeutically in BOTULISM.


Gastro-Esophageal Reflux
GERD
Gastroesophageal Reflux Disease
Gastric Acid Reflux
Reflux, Gastroesophageal
Gastric Acid Reflux Disease
Gastro-oesophageal Reflux
Gastroesophageal Reflux
Esophageal Reflux

Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.


Pathological processes in the SIGMOID COLON region of the large intestine (INTESTINE, LARGE).


Sex Differences
Sexual Dimorphism
Sex Dimorphism
Sex Characteristics

Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.


Non-gestational Choriocarcinoma
Choriocarcinoma, Non-gestational

A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.


Hydrocyanic Acid
Zyklon B
Hydrogen Cyanide

Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.


Large aggregates of CELESTIAL STARS; COSMIC DUST; and gas. (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed)


Muscarinic Antagonists
Cholinergic Muscarinic Antagonists
Antimuscarinics
Antimuscarinic Agents

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.


Printing, Three-Dimensional
Three-Dimensional Printing
3-Dimensional Printing
3-D Printing
3D Printing

Process for making, building or constructing a physical object from a three-dimensional digital model by laying down many successive thin layers of building material.


Vitamin G
Vitamin B 2
Riboflavin
Vitamin B2

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.


STRIATED MUSCLE cell components which anchor the MYOFIBRILS from the Z-bands to the SARCOLEMMA and EXTRACELLULAR MATRIX. Costameric proteins include the proteins of FOCAL ADHESIONS.


An insect chemosterilant and an antineoplastic agent.


Atrioventricular Canal Cushions
Endocardial Cushions

A fetal heart structure that is the bulging areas in the cardiac septum between the HEART ATRIA and the HEART VENTRICLES. During development, growth and fusion of endocardial cushions at midline forms the two atrioventricular canals, the sites for future TRICUSPID VALVE and BICUSPID VALVE.


Receptor, Insulin-Like Growth Factor Type 2

Receptors, Insulin-Like Growth Factor II

A receptor that is specific for IGF-II and mannose-6-phosphate. The receptor is a 250-kDa single chain polypeptide which is unrelated in structure to the type 1 IGF receptor (RECEPTOR, IGF TYPE 1) and does not have a tyrosine kinase domain.


Neuronal Apoptosis-Inhibitory Protein
NAIP Protein

An inhibitor of apoptosis protein that was initially identified during analysis of CHROMOSOME DELETIONS associated with SPINAL MUSCULAR ATROPHY. Naip contains a nucleotide binding oligomerization domain and a carboxy-terminal LEUCINE rich repeat.


Dilatation & Curettage
Dilatation and Curettage
Curettage and Dilatation

Dilatation of the cervix uteri followed by a scraping of the endometrium with a curette.


Secretory Phospholipase A2
Phospholipases A2, Secretory
Phospholipases A2, Secreted
sPLA2s
sPLA(2)
Secreted Phospholipases A2
SPLA2 Phospholipases

A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing multiple disulfide-bonds and access their substrate via an interfacial binding site that interacts with phospholipid membranes. In addition specific PHOSPHOLIPASE A2 RECEPTORS can bind to and internalize the enzymes.


A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.


Type II Complex Regional Pain Syndrome
Deafferentation Pain
CRPS Type II
Causalgia
Causalgia Syndrome
Complex Regional Pain Syndrome Type II

A complex regional pain syndrome characterized by burning pain and marked sensitivity to touch (HYPERESTHESIA) in the distribution of an injured peripheral nerve. Autonomic dysfunction in the form of sudomotor (i.e., sympathetic innervation to sweat glands), vasomotor, and trophic skin changes may also occur. (Adams et al., Principles of Neurology, 6th ed, p1359)


Receptors, Neurotrophin
Receptors, Neurotrophic Factor
NGF Receptors
Neurotrophin Receptors
Receptors, Nerve Growth Factor
Neurotrophic Factor Receptor
Receptors, NGF
Nerve Growth Factor Receptors

Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.


Glutarol Cidex Glutaral Glutaraldehyde Sporicidin Glutardialdehyde Sonacide Novaruca Diswart Sekumatic Korsolex Gludesin

One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.


Clostridium welchii
Clostridium perfringens

The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.


Unprofessional Behavior
Professional Misconduct
Misconduct, Professional

Violation of laws, regulations, or professional standards.


A multilineage cell growth factor secreted by LYMPHOCYTES; EPITHELIAL CELLS; and ASTROCYTES which stimulates clonal proliferation and differentiation of various types of blood and tissue cells.


Mendiaxon 7-Hydroxy-4-methyl-coumarin Imecromone 4-Methylumbelliferone Hymecromone Methylumbelliferone Cholestil Resocyanine

A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.


Vestibule of Ear
Vestibular Apparatus
Vestibulum Auris
Vestibular Labyrinth
Vestibule, Labyrinth
Ear Vestibule

An oval, bony chamber of the inner ear, part of the bony labyrinth. It is continuous with bony COCHLEA anteriorly, and SEMICIRCULAR CANALS posteriorly. The vestibule contains two communicating sacs (utricle and saccule) of the balancing apparatus. The oval window on its lateral wall is occupied by the base of the STAPES of the MIDDLE EAR.


MafB Transcription Factors
MafB Transcription Factor
MafB Proteins

A large maf protein that regulates HINDBRAIN development, contributes to CELL DIFFERENTIATION of MONOCYTES, and interacts with ETS-1 TRANSCRIPTION FACTOR.


Ro 3-1428
ETYA
5,8,11,14 Eicosatetraynoic Acid
5,8,11,14-Eicosatetraynoic Acid

A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).


Cyclin-Dependent Kinase Inhibitor 2B
INK4b Cyclin-Dependent Kinase Inhibitor
p15 CDK4 Inhibitor
Cyclin-Dependent Kinase Inhibitor p15
CDKN2B Protein
p15INK4B Protein
INK4B Protein

An INK4 cyclin-dependent kinase inhibitor containing four ANKYRIN-LIKE REPEATS. INK4B is often inactivated by deletions, mutations, or hypermethylation in HEMATOLOGIC NEOPLASMS.


Equine Plague
African Horsesickness
African Horse Sickness

An insect-borne reovirus infection of horses, mules and donkeys in Africa and the Middle East; characterized by pulmonary edema, cardiac involvement, and edema of the head and neck.


The anatomical frontal portion of the mandible, also known as the mentum, that contains the line of fusion of the two separate halves of the mandible (symphysis menti). This line of fusion divides inferiorly to enclose a triangular area called the mental protuberance. On each side, inferior to the second premolar tooth, is the mental foramen for the passage of blood vessels and a nerve.


ISCOM
Immuno-Stimulating Complexes
ISCOMs
Immunostimulating Complexes

A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.


Pulmonary Surfactant-Associated Protein C

Pulmonary Surfactant-Associated Protein SP-C

A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.


Aged, 80 and over
Nonagenarians
Centenarians
Oldest Old
Octogenarians


NMUPD
Prescription Medicine Misuse
Non-Medical Use of Prescription Drugs
Prescription Drug Misuse

Improper use of prescription drugs or medications outside the intended purpose, scope, or guidelines for use.


Fatty Acids, Volatile
Fatty Acids, Short-Chain

Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.


Urtica dioica
Stinging Nettle
Nettle, Stinging

A plant species of the genus Urtica, family URTICACEAE. Roots have been used to treat PROSTATIC HYPERPLASIA. Leaves are edible after the stinging quality is eliminated by brief heating.


Index, Dental Plaque
Dental Plaque Indexes
Dental Plaque Index
Indices, Dental Plaque
Dental Plaque Indices
Indexes, Dental Plaque

An index which scores the degree of dental plaque accumulation.


Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.


Amino Acids, Neutral
Neutral Amino Acids

Amino acids with uncharged R groups or side chains.


Stroop Effect
Stroop Test
Stroop Task
Stroop Paradigm

The automatic nature of accessing word meaning.


Costal Chondritis
Tietze's Syndrome
Chondritis, Costal

Idiopathic painful nonsuppurative swellings of one or more costal cartilages, especially of the second rib. The anterior chest pain may mimic that of coronary artery disease. (Dorland, 27th ed.)


Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.


Mouth and Tooth Diseases
Stomatognathic Diseases
Dental Diseases

General or unspecified diseases of the stomatognathic system, comprising the mouth, teeth, jaws, and pharynx.


Anthranilate Synthetase
Anthranilate Synthase
Anthranilate Synthase Component I

An enzyme that catalyzes the formation of anthranilate (o-aminobenzoate) and pyruvic acid from chorismate and glutamine. Anthranilate is the biosynthetic precursor of tryptophan and numerous secondary metabolites, including inducible plant defense compounds. EC 4.1.3.27.


Soluble Guanylyl Cyclase, beta Subunit
Soluble Guanylyl Cyclase, alpha Subunit
Nitric Oxide Receptor
Soluble Guanylate Cyclase
Nitric Oxide-Sensitive Guanylyl Cyclase
Soluble Guanylyl Cyclase
Nitric Oxide Receptors
Receptor, Nitric Oxide

A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.


COPEB Protein
Core Promoter Element Binding Protein
CPBP Protein
Kruppel-Like Factor 6

A Kruppel-like transcription factor that contains three C-terminal CYS2-HIS2 ZINC FINGERS and binds to GC RICH SEQUENCE (GC box) in upstream gene promoters. It functions as a transcriptional activator, tumor suppressor, and may regulate growth and development of B-cells.


Mannose-6-Phosphate Isomerase
Phosphomannose Isomerase
Mannosephosphate Isomerase

An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. EC 5.3.1.8.


Tuberculosis
Kochs Disease
Koch's Disease
Mycobacterium tuberculosis Infection

Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.


Measurement of oxygen and carbon dioxide in the blood.


Utilization of wireless phones for communication.


Animal searching behavior. The variable introductory phase of an instinctive behavior pattern or sequence, e.g., looking for food, or sequential courtship patterns prior to mating.


Proto-Oncogene Proteins ets-2
Proto-Oncogene Protein ets-2
Proto-Oncogene Protein c-ets-2
Proto-Oncogene Proteins c-ets-2
c-ets-2 Protein

A ubiquitously expressed ets proto-oncogene protein that may play a role in regulation of CELL PROLIFERATION and CELL DIFFERENTIATION.


Child Nutritional Physiological Phenomena

Nutritional physiology of children aged 2-12 years.


Inappropriate GH Secretion Syndrome (Acromegaly)

Somatotropin Hypersecretion Syndrome (Acromegaly)

Inappropriate Growth Hormone Secretion Syndrome (Acromegaly)

A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)


Secretory Protein I, Parathyroid Gland
Parathyroid Secretory Protein
CHGA Protein
Chromogranin A

A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.


Hypocholesteremic Agents
Anticholesteremic Drugs
Cholesterol Inhibitors
Anticholesteremics
Anticholesteremic Agents
Inhibitors, Cholesterol

Substances used to lower plasma CHOLESTEROL levels.


Neuromuscular Blocking Agents, Competitive

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.


V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog Protein

V-Ets Avian Erythroblastosis Virus E26 Oncogene Related Protein

A trans-activator and member of the erythroblast transformation-specific family of transcriptions factors that contain a characteristic ETS MOTIF. It is required for PLATELET CELL ADHESION to the subendothelium and associates with CHIMERIC ONCOGENE PROTEINS in PROSTATE CANCER; EWING'S SARCOMA; and ACUTE MYELOID LEUKEMIA.


The club-moss plant family of the order Lycopodiales, class Lycopodiopsida, division Lycopodiophyta, subkingdom TRACHEOPHYTA. The common name of clubmoss applies to several genera of this family. Despite the name this is not one of the true mosses (BRYOPSIDA ).


Fetofetal Transfusion Syndrome
Cross-Transfusion, Intrauterine
Twin Transfusion Syndrome
Fetofetal Transfusion
Twin-to-Twin Transfusion Syndrome
Fetal Transfusion Syndrome
Twin Transfusion
Twin Twin Transfusion Syndrome
Intrauterine Cross-Transfusion

Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)


Lecithinases Phospholipases Lecithinase Phospholipase

A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-.


Linear dermal scars accompanied by epidermal atrophy that affects skin that is subjected to continuous stretching. They usually do not cause any significant medical problems, only cosmetic problems.


Collagen Receptor
Receptors, Collagen
Collagen Receptors

Cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include DISCOIDIN DOMAIN RECEPTORS; INTEGRINS; and GP6, one of the PLATELET MEMBRANE GLYCOPROTEINS.


Lateral Internal Anal Sphincterotomy
Internal Anal Sphincterotomy
Internal Sphincterotomy
Lateral Internal Sphincterotomy
Lateral Sphincterotomy

Surgical incision of the INTERNAL ANAL SPHINCTER typically in the treatment of FISSURE IN ANO; chronic ANAL FISSURE and FECAL INCONTINENCE.


The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.


Diabetic Angiopathies
Diabetic Vascular Complications
Diabetic Vascular Diseases
Microangiopathy, Diabetic

VASCULAR DISEASES that are associated with DIABETES MELLITUS.


A plant genus of the family TILIACEAE. Some species in this genus are called Limetree which is nearly the same as the common name for lime (CITRUS AURANTIIFOLIA). Some people are allergic to the POLLEN.


Contraceptives, Oral, Combined
Contraceptive Agents, Female, Combined
Oral Contraceptives, Combined

Fixed drug combinations administered orally for contraceptive purposes.


3'-Amino-3'-deoxy-N,N-dimethyladenosine
Puromycin Aminonucleoside
Aminonucleoside

PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineoplastic properties and can cause nephrosis.


Lead-Induced Nervous System Diseases
Poisoning, Lead, Neurologic
Nervous System Poisoning, Lead
Neurotoxicity Syndrome, Lead
Nervous System Diseases, Lead-Induced
Lead Poisoning, Nervous System
Poisoning, Lead, Nervous System
Lead Poisoning, Neurologic
Plumbism, Neurologic
Plumbism, Nervous System

Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, NERVOUS SYSTEM, CHILDHOOD) and adults (LEAD POISONING, NERVOUS SYSTEM, ADULT). In children, lead poisoning typically produces an encephalopathy. In adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.


Enterobacter sakazakii
Cronobacter sakazakii

A species of gram-negative bacteria in the genus CHRONOBACTER, found in the environment and in foods.


A subfamily of MARVEL domain-containing proteins that are found in SYNAPTIC VESICLES, where they may play a role in modulating neuronal signaling.


Lamina II
Substantia Gelatinosa of Rolando
Lamina 2
Substantia Gelatinosa

Gelatinous-appearing material in the dorsal horn of the spinal cord, consisting chiefly of Golgi type II neurons and some larger nerve cells.


Serum Albumin, Human
Albumin Human
Human Serum Albumin
Human Albumin

Serum albumin from humans. It is an essential carrier of both endogenous substances, such as fatty acids and BILIRUBIN, and of XENOBITOICS in the blood.


Angioosteohypertrophy Syndrome
Angio-Osteohypertrophy Syndrome
Klippel-Trenaunay Syndrome
Klippel-Trenaunay-Weber Syndrome
Congenital Dysplastic Angiopathy
KTW Syndrome
Klippel Trenaunay Syndrome
Klippel-Trenaunay Disease
Klippel-Trénaunay-Weber Syndrome

A congenital disorder that is characterized by a triad of capillary malformations (HEMANGIOMA), venous malformations (ARTERIOVENOUS FISTULA), and soft tissue or bony hypertrophy of the limb. This syndrome is caused by mutations in the VG5Q gene which encodes a strong angiogenesis stimulator.


Progesterone-Binding Globulin
Progesterone-Binding Protein
Transprogestin

A glycoprotein migrating as alpha 1-globulin, molecular weight 70,000 to 120,000. The protein, which is present in increased amounts in the plasma during pregnancy, binds mainly progesterone, with other steroids including testosterone competing weakly.


CUG Triplet Repeat, RNA-Binding Protein 1

CUGBP, Elav-Like Family Member 1 Protein

A member of the CELF PROTEINS family which binds GU rich elements (GREs) and CUG-triplet repeats in the 3'UTR of mammalian mRNA transcripts that undergo rapid turnover. It also binds AU-rich elements (AREs or EDEN-like) in the 3'UTR of JUN and FOS mRNAs. Mutations in the human CELF1 gene are associated with MYOTONIC DYSTROPHY type 1.


Frizzled Receptor
Receptors, Frizzled
Frizzled Receptors
Frizzled Proteins

A family of seven-pass transmembrane cell-surface proteins that combines with LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 or LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 to form receptors for WNT PROTEINS. Frizzled receptors often couple with HETEROTRIMERIC G PROTEINS and regulate the WNT SIGNALING PATHWAY.


Variation in health status arising from different causal factors to which each birth cohort in a population is exposed as environment and society change.


Energy released by nuclear fission or nuclear fusion.


Infections, Hookworm
Bunostomiasis
Hookworm Infections

Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.


Voltage-Gated Sodium Channel beta-3 Subunit

A voltage-gated sodium channel beta subunit subtype that non-covalently associates with voltage-gated alpha subunits. Defects in the SCN3B gene which codes for this beta subunit are associated with Brugada syndrome 7.


Computational Prediction of Drug-Target Interactions

The entire process of bringing a new drug to the market. It includes both preclinical and clinical testing, and regulatory approval.


Cathepsin B-Like Proteinase
Cathepsin B
Cathepsin B1

A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.


Test-Tube Fertilization
Test-Tube Babies
Fertilizations in Vitro
In Vitro Fertilization
Fertilization in Vitro

An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.


Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.


Healthcare Disparities
Healthcare Inequalities
Disparities, Healthcare
Health Care Inequalities
Health Care Disparities
Healthcare Disparity

Differences in access to or availability of medical facilities and services.


Gated Imaging Techniques, Respiratory
Respiratory-Gated Imaging Techniques

Timing the acquisition of imaging data to specific points in the breathing cycle to minimize image blurring and other motion artifacts. The images are used diagnostically and also interventionally to coordinate radiation treatment beam on/off cycles to protect healthy tissues when they move into the beam field during different times in the breathing cycle.


The adaptive superiority of the heterozygous GENOTYPE with respect to one or more characters in comparison with the corresponding HOMOZYGOTE.


Nanostructured Materials
Nanostructures
Nanomaterials

Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.


Body Fat Distribution
Body Fat Patterning

Deposits of ADIPOSE TISSUE throughout the body. The pattern of fat deposits in the body regions is an indicator of health status. Excess ABDOMINAL FAT increases health risks more than excess fat around the hips or thighs, therefore, WAIST-HIP RATIO is often used to determine health risks.


Small-Conductance Calcium-Activated Potassium Channels

A major class of calcium-activated potassium channels that are found primarily in excitable CELLS. They play important roles in the transmission of ACTION POTENTIALS and generate a long-lasting hyperpolarization known as the slow afterhyperpolarization.


A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose.


Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.


Fas-Associating Protein with Death Domain

A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.


Bee Venom
Bee Venoms
Apis Venoms
Apitoxin

Toxins obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.


Large Maf Transcription Factors
Maf Transcription Factors, Large

A family of high molecular weight Maf transcription factors that contain distinct activation domains.


Medium-Chain Acyl-Coenzyme A Dehydrogenase

A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. It forms a complex with ELECTRON TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE.


ATP-Methionine S-Adenosyltransferase
Methionine Adenosyltransferase
S-Adenosylmethionine Synthetase

An enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. EC 2.5.1.6.


An endocellulase with specificity for the hydrolysis of 1,3- or 1,4-linkages in beta-D-glucans. This enzyme specifically acts on sites where reducing glucose residues are substituted at the 3 position.


Tricresyl Phosphates
Tricresyl Phosphate
Tritolyl Phosphates
Tritolyl Phosphate

A mixture of isomeric tritolyl phosphates. Used in the sterilization of certain surgical instruments and in many industrial processes.


Maxillomandibular Fixation
Jaw Fixation Technics
Jaw Fixation Techniques

The stable placement of surgically induced fractures of the mandible or maxilla through the use of elastics, wire ligatures, arch bars, or other splints. It is used often in the cosmetic surgery of retrognathism and prognathism. (From Dorland, 28th ed, p636)


Ras Homolog Enriched in Brain Protein
Rheb GTPase
Rheb Protein

A GTP-binding protein with low intrinsic GTPase activity that activates MTORC1 protein kinase activity.


P450 CYP2C19 Inducers
Cytochrome P-450 CYP2C19 Inducers
CYP2C19 Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP2C19.


Integration Host Factor beta Subunit
Integration Host Factors
Integration Host Factor alpha Subunit
Host Factor Protein
Integration Host Factor

Bacterial proteins that are used by BACTERIOPHAGES to incorporate their DNA into the DNA of the "host" bacteria. They are DNA-binding proteins that function in genetic recombination as well as in transcriptional and translational regulation.


Alcohol, Ethyl
Grain Alcohol
Absolute Alcohol
Ethanol

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.


Yperite
Psoriazin
Yellow Cross Liquid
Mustardgas
Di-2-chloroethyl Sulfide
Mustard Gas
Dichlorodiethyl Sulfide
Sulfur Mustard
Bis(beta-chloroethyl) Sulfide

Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).


Colloid or hyaline bodies lying beneath the retinal pigment epithelium. They may occur either secondary to changes in the choroid that affect the pigment epithelium or as an autosomal dominant disorder of the retinal pigment epithelium.


Within most types of eukaryotic CELL NUCLEUS, a distinct region, not delimited by a membrane, in which some species of rRNA (RNA, RIBOSOMAL) are synthesized and assembled into ribonucleoprotein subunits of ribosomes. In the nucleolus rRNA is transcribed from a nucleolar organizer, i.e., a group of tandemly repeated chromosomal genes which encode rRNA and which are transcribed by RNA polymerase I. (Singleton & Sainsbury, Dictionary of Microbiology & Molecular Biology, 2d ed)


Pay for Performance
Reimbursement, Incentive
Incentive Reimbursement

Explicit financial incentives designed to improve performance quality and a quantitative measure of quality.


Patency Tests, Fallopian Tube
Fallopian Tube Patency Tests

Methods for assessing the patency of the fallopian tubes.


Hereditary Complement Deficiency Diseases

Inherited Complement Deficiency Diseases

Genetic disorders due to mutations in genes involved in COMPLEMENT SYSTEM PROTEINS. They are often classified into distinct pathway of complement activation where causative mutations are found (e.g., classical pathway, lectin pathway, alternative pathway, and terminal complement pathway).


Epidermodysplasia Verruciformis
Lutz-Lewandowsky Disease
Lewandowsky-Lutz Disease

An autosomal recessive trait with impaired cell-mediated immunity. About 15 human papillomaviruses are implicated in associated infection, four of which lead to skin neoplasms. The disease begins in childhood with red papules and later spreads over the body as gray or yellow scales.


Panitumumab
ABX-EGF Monoclonal Antibody
Panitumumab Antibody, Human
ABX-EGF MAb
Vectibix

Recombinant human monoclonal antibody that binds to and inhibits the function of the EPIDERMAL GROWTH FACTOR RECEPTOR. It is used in the treatment of EGFR-expressing metastatic colorectal cancer that expresses wild-type ras gene (see GENES, RAS).


Dental Enamel Solubility
Enamel Solubility, Dental
Solubility, Dental Enamel

The susceptibility of the DENTAL ENAMEL to dissolution.


Human Chorionic Gonadotropin, beta Subunit

Chorionic Gonadotropin, beta Polypeptide, Human

Chorionic Gonadotropin, beta Chain, Human

Chorionic Gonadotropin, beta Subunit, Human

The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.


An NAD-dependent 3-hydroxyacyl CoA dehydrogenase that has broad specificity with regards to the acyl chain length of the substrate.


Tufted Capuchin Monkeys
Sapajus apella
Guianan Brown Capuchin
Cebus apella
Cebus apella macrocephalus

A species of the genus SAPAJUS, subfamily CEBINAE, family CEBIDAE, consisting of tufted capuchin monkeys with characteristic black head cap and sideburn coloration with tufts of dark fur above the ears. S. apella was known as Cebus apella and C. a. apella.


p27Kip1 Protein
p27 CDK Inhibitor
Cyclin-Dependent Kinase Inhibitor p27
CDK Inhibitor p27
CDKN1B Protein
CDKN4 Protein
p27 Kip1 Protein
Cyclin-Dependent Kinase Inhibitor 1B

A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.


Procedures for the improvement or enhancement of the appearance of the visible parts of the body.


SOX-9 Transcription Factor
SOX9 Transcription Factor

A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.


A genus of tick-borne protozoan parasites that infests the red blood cells of mammals, including humans. There are many recognized species, and the distribution is world-wide.


Product Surveillance, Postmarketing
Drug Surveillance, Postmarketing
Product Surveillance, Post-Marketing
Evaluation Studies, Postmarketing
Postmarketing Product Surveillance

Surveillance of drugs, devices, appliances, etc., for efficacy or adverse effects, after they have been released for general sale.


Thrush
Candidiasis, Oral
Moniliasis, Oral

Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)


Verbascum thapsus
Verbascum phlomoides
Verbascum
Mullein

A plant genus of the family Scrophulariaceae.


Pulsatile Flow
Flow, Pulsating
Perfusion, Pulsatile

Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.


Health Occupations Students
Students, Health Occupations

Individuals enrolled in a school or formal educational program in the health occupations.


Mescaline 3,4,5-Trimethoxyphenethylamine Mezcalin Trimethoxyphenethylamine Peyote

Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.


An antiviral agent effective against pox viruses.


Primary Oxalosis
Primary Oxaluria
Hyperoxaluria, Primary
Primary Hyperoxaluria
Oxaluria, Primary

A genetic disorder characterized by excretion of large amounts of OXALATES in urine; NEPHROLITHIASIS; NEPHROCALCINOSIS; early onset of RENAL FAILURE; and often a generalized deposit of CALCIUM OXALATE. There are subtypes classified by the enzyme defects in glyoxylate metabolism.


Early Growth Response Transcription Factor 3

An early growth response transcription factor that is essential for the development of MUSCLE SPINDLES.


Hospital Legislation
Legislation, Hospital

Laws and regulations concerning hospitals, which are proposed for enactment or enacted by a legislative body.


RNA 3' End Processing
3' End Processing, RNA

The steps that generate the 3' ends of mature RNA molecules. For most mRNAs (RNA, MESSENGER), 3' end processing referred to as POLYADENYLATION includes the addition of POLY A.


An enzyme that catalyzes the transfer of methyl groups from S-adenosylmethionine to free carboxyl groups of a protein molecule forming methyl esters. EC 2.1.1.-.


Antisense OligoDNA
Anti-Sense Oligodeoxyribonucleotides
Oligodeoxyribonucleotides, Antisense
Antisense Oligodeoxyribonucleotides
Oligodeoxyribonucleotide, Antisense

Short fragments of DNA that are used to alter the function of target RNAs or DNAs to which they hybridize.


Lupus Erythematosus Panniculitis
Lupus Profundus
Panniculitis, Lupus Erythematosus
Lupus Panniculitis
Lupus Erythematosus Profundus

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.


The larger of two types of nuclei in ciliate protozoans. It is the transcriptionally active nucleus of the vegetative cells as distinguished from the smaller transcriptionally inert GERMLINE MICRONUCLEUS.


Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)


First World War
Great War
World War, 1914-1918
World War I
1st World War

Global conflict primarily fought on European continent, that occurred between 1914 and 1918.


Pharmacist-Patient Relations
Contacting Clients
Professional Patient Relationship
Professional-Patient Relations

Interactions between health personnel and patients.


A type of POST-TRANSLATIONAL PROTEIN MODIFICATION by SMALL UBIQUITIN-RELATED MODIFIER PROTEINS (also known as SUMO proteins).


A family of membrane-associated proteins responsible for the attachment of the cytoskeleton. Erythrocyte-related isoforms of ankyrin attach the SPECTRIN cytoskeleton to a transmembrane protein (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE) in the erythrocyte plasma membrane. Brain-related isoforms of ankyrin also exist.


Encephabol
Enerbol
Pyrithioxin
Piritinol
Dipyridoxolyldisulfide
Pyritinol Hydrochloride
Pyritinol
Piriditol
Pyrithioxine
Bonifen
Piritoxina
Pyridoxinedisulfide

A neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.


Immunologic Enhancement of Grafts
Graft Enhancement, Immunological
Graft Enhancement, Immunologic
Graft Enhancement
Enhancement, Immunologic Graft
Immunologic Graft Enhancement

The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.


Infections, Meningococcal
Meningococcal Infections
Meningococcal Disease

Infections with bacteria of the species NEISSERIA MENINGITIDIS.


Pathological processes of the inner ear (LABYRINTH) which contains the essential apparatus of hearing (COCHLEA) and balance (SEMICIRCULAR CANALS).


Cytochrome P450, Family 2, Subfamily C, Polypeptide 8

A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE


Large Ribosomal Subunits, Bacterial
Bacterial Large Ribosomal Subunits
Ribosomal Subunits, 50S, Bacterial
50S Ribosomal Subunits, Bacterial
Ribosome Subunits, Large, Bacterial
50S Ribosome Subunits, Bacterial
Ribosome Subunits, 50S, Bacterial
Ribosomal Subunits, Large, Bacterial
Bacterial Large Ribosome Subunits
Large Ribosome Subunits, Bacterial

The large subunit of the eubacterial 70s ribosome. It is composed of the 23S RIBOSOMAL RNA, the 5S RIBOSOMAL RNA, and about 37 different RIBOSOMAL PROTEINS.


Stretch Receptors, Muscle
Muscle Stretch Receptors
Receptors, Stretch, Muscle
Muscle Spindles
Neuromuscular Spindles

Skeletal muscle structures that function as the MECHANORECEPTORS responsible for the stretch or myotactic reflex (REFLEX, STRETCH). They are composed of a bundle of encapsulated SKELETAL MUSCLE FIBERS, i.e., the intrafusal fibers (nuclear bag 1 fibers, nuclear bag 2 fibers, and nuclear chain fibers) innervated by SENSORY NEURONS.


Glasses
Sun Glasses, Prescription
Spectacles
Eyeglasses

A pair of ophthalmic lenses in a frame or mounting which is supported by the nose and ears. The purpose is to aid or improve vision. It does not include goggles or nonprescription sun glasses for which EYE PROTECTIVE DEVICES is available.


Uveitis, Sympathetic
Ophthalmia, Sympathetic

Granulomatous uveitis which follows in one eye after a penetrating injury to the other eye; the secondarily affected eye is called the sympathizing eye, and the injured eye is called the exciting or activating eye.


Phosphodiesterases
Phosphoric Diester Hydrolases

A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.


Skin Syphilis
Syphilids
Syphilis, Cutaneous

Cutaneous lesions arising from infection with Treponema pallidum. In the primary stage, 18-21 days following infection, one or more chancres appear. If untreated, the subsequent stages of the disease appear as syphilids. These eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p409)


Infections, Bacteroides
Bacteroides Infections

Infections with bacteria of the genus BACTEROIDES.


v-erb-a Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian) Protein

A cell surface protein-tyrosine kinase receptor that has specificity for EPIREGULIN; BETACELLIN; NEUREGULINS; and HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR.


Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.


A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN G.


Fushi Tarazu Transcription Factors
Segmentation Protein Fushi Tarazu
Fushi Tarazu Protein

Fushi tarazu transcription factors were originally identified in DROSOPHILA. They are found throughout ARTHROPODS and play important roles in segmentation and CENTRAL NERVOUS SYSTEM development.


Cat Scratch Fever
Catscratch Disease
Inoculation Lymphoreticulosis
Bartonella henselae Infection
Inoculative Lymphoreticulosis
Cat-Scratch Disease

A self-limiting bacterial infection of the regional lymph nodes caused by AFIPIA felis, a gram-negative bacterium recently identified by the Centers for Disease Control and Prevention and by BARTONELLA HENSELAE. It usually arises one or more weeks following a feline scratch, with raised inflammatory nodules at the site of the scratch being the primary symptom.


A plant genus of the family ASTERACEAE. Members contain triterpenoid sapogenins.


Porcelain
Porcelain, Dental
Dental Porcelain

A type of porcelain used in dental restorations, either jacket crowns or inlays, artificial teeth, or metal-ceramic crowns. It is essentially a mixture of particles of feldspar and quartz, the feldspar melting first and providing a glass matrix for the quartz. Dental porcelain is produced by mixing ceramic powder (a mixture of quartz, kaolin, pigments, opacifiers, a suitable flux, and other substances) with distilled water. (From Jablonski's Dictionary of Dentistry, 1992)


Cytalopram
Lexapro
Lu-10-171
Citalopram
Celexa
Escitalopram Oxalate
Seropram
Citalopram Hydrobromide
Escitalopram

Trade name of escitalopram, the active S-enantiomer of the racemic citalopram.


Puringergic Receptor P2Y, G-Protein Coupled, 2

A subclass of purinergic P2Y receptors that have a preference for ATP and UTP. The activated P2Y2 receptor acts through a G-PROTEIN-coupled PHOSPHATIDYLINOSITOL and intracellular CALCIUM SIGNALING pathway.


Receptors, Drug
Drug Receptors
Drug Receptor

Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.


Momordica charantia
Gourd, Bitter
Karela
Bitter Melon
Bitter Gourd

A plant species of the family CUCURBITACEAE. It is a source of ribosome-inactivating proteins and triterpene glycosides.


Pancreatic Insufficiency and Bone Marrow Dysfunction

Metaphyseal Chondrodysplasia, Shwachman Type

An inherited syndrome characterized by EXOCRINE PANCREATIC INSUFFICIENCY; hematologic abnormalities (e.g., bone marrow hypoplasia), and skeletal abnormalities (e.g., metaphyseal chondroplasia). GERMLINE MUTATIONS in the SBDS gene are associated with Shwachman-Diamond Syndrome.


Agenesis of Corpus Callosum
Corpus Callosum Dysgenesis
Corpus Callosum Malformation
Absence of Corpus Callosum
Corpus Callosum, Agenesis Of
Corpus Callosum Agenesis
Corpus Callosum Hypogenesis

Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.


Devices designed to provide protection against injury.


Sex Chromatin
Chromatin, Sex
Barr Bodies

In the interphase nucleus, a condensed mass of chromatin representing an inactivated X chromosome. Each X CHROMOSOME, in excess of one, forms sex chromatin (Barr body) in the mammalian nucleus. (from King & Stansfield, A Dictionary of Genetics, 4th ed)


Laryngeal Tuberculosis
Tuberculosis of Larynx
Tuberculosis, Laryngeal

Tuberculosis involving the larynx, producing ulceration of the VOCAL CORDS and the LARYNGEAL MUCOSA.


Atrial Function, Right
Right Atrial Function

The hemodynamic and electrophysiological action of the RIGHT ATRIUM.


Chondroitin Sulfate Proteoglycan 3
Neurocan

A hyalectin family member that is expressed in neuronal tissue and plays a role in neuronal CELL ADHESION.


Doppler Effect
Doppler Shift
Effect, Doppler

Changes in the observed frequency of waves (as sound, light, or radio waves) due to the relative motion of source and observer. The effect was named for the 19th century Austrian physicist Johann Christian Doppler.


The functional hereditary units of VIRUSES.


L-Phenylalanine
Phenylalanine, L-Isomer
Phenylalanine
Endorphenyl

An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.


Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.


Gingival Curettage
Periodontal Epithelial Debridement
Subgingival Curettage

Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)


A plant genus of the family ASTERACEAE. Members contain eudesmane and elemane SESQUITERPENES.


Conflict between RUSSIA (Pre-1917); the OTTOMAN EMPIRE; ENGLAND; FRANCE; and Sardinia.


Consultation, Remote
Teleconsultation
Remote Consultation

Consultation via remote telecommunications, generally for the purpose of diagnosis or treatment of a patient at a site remote from the patient or primary physician.


A hernia caused by weakness of the anterior ABDOMINAL WALL due to midline defects, previous incisions, or increased intra-abdominal pressure. Ventral hernias include UMBILICAL HERNIA, incisional, epigastric, and spigelian hernias.


Meningococci, Serogroup A
Meningococcus, Serogroup A
Neisseria meningitidis, Serogroup A

Strains of Neisseria meningitidis responsible for most outbreaks of meningococcal disease in Western Europe and the United States in the first half of the 20th century. They continue to be a major cause of disease in Asia and Africa, and especially localized epidemics in Sub-Sahara Africa.


Listeria Infections
Listeriosis
Infections, Listeria

Infections with bacteria of the genus LISTERIA.


A syndrome characterized by headache, neck stiffness, low grade fever, and CSF lymphocytic pleocytosis in the absence of an acute bacterial pathogen. Viral meningitis is the most frequent cause although MYCOPLASMA INFECTIONS; RICKETTSIA INFECTIONS; diagnostic or therapeutic procedures; NEOPLASTIC PROCESSES; septic perimeningeal foci; and other conditions may result in this syndrome. (From Adams et al., Principles of Neurology, 6th ed, p745)


Neoplasms, Vascular Tissue
Blood Vessel Tumors
Vascular Tissue Neoplasms

Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.


Agricultural Worker Disease
Agricultural Workers' Diseases
Agricultural Worker's Disease

Diseases in persons engaged in cultivating and tilling soil, growing plants, harvesting crops, raising livestock, or otherwise engaged in husbandry and farming. The diseases are not restricted to farmers in the sense of those who perform conventional farm chores: the heading applies also to those engaged in the individual activities named above, as in those only gathering harvest or in those only dusting crops.


Meningitides, Bacterial
Meningitis, Bacterial
Bacterial Meningitides
Bacterial Meningitis

Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.


Receptors, CXCR5
Burkitt Lymphoma Receptor 1
CXCR5 Receptors
Antigens, CD185
CXC Chemokine Receptor 5
CD185 Antigens

CXCR receptors isolated initially from BURKITT LYMPHOMA cells. CXCR5 receptors are expressed on mature, recirculating B-LYMPHOCYTES and are specific for CHEMOKINE CXCL13.


STAT (Signal Transducers and Activators of Transcription) Proteins

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.


Proteins, Acute-Phase
Acute-Phase Proteins
Acute-Phase Reactants
Reactants, Acute-Phase
Acute-Phase Protein
Acute-Phase Glycoproteins

Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.


Dental Prosthesis Repair
Prosthesis Repairs, Dental
Repairs, Dental Prosthesis
Prosthesis Repair, Dental
Repair, Dental Prosthesis
Dental Prosthesis Repairs

The process of reuniting or replacing a broken or worn dental prosthesis or its part.


Anaphylactoid Shock
Shock, Anaphylactic
Anaphylactoid Reaction
Anaphylactic Reaction
Anaphylaxis

An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.


Death Domain Receptors
Receptors, DR Family
Death Receptors
Receptors, Death Domain Family
Receptors, Death Domain

A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.


Primary Hyperthyroidism
Hyperthyroid
Hyperthyroidism

Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.


Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).


Circle of Willis
Willis' Circle
Cerebral Arterial Circle

A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.


Dental Stress Analysis
Analyses, Dental Stress
Stress Analyses, Dental
Analysis, Dental Stress
Stress Analysis, Dental

The description and measurement of the various factors that produce physical stress upon dental restorations, prostheses, or appliances, materials associated with them, or the natural oral structures.


Praying Mantis
Mantids
Mantodea
Mantidae

An order of insects, comprising a single family (Mantidae), restricted almost entirely to the tropics. Only one species, the praying mantis (Mantis religiosa), is found in temperate habitats.


Adult Progeria
Werner's Syndrome
Progeria, Adult
Werners Syndrome
Werner Syndrome
Adult Premature Aging Syndrome

An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease.


The management and maintenance of colonies of honeybees.


SCA1 Protein
Spinocerebellar Ataxia Type 1 Protein
Ataxin-1
Atxn-1 Protein
Ataxin-1 Protein
Atxn1 Protein

A chromatin-binding factor that represses Notch signaling and associates with RNA. Expansion of the polyglutamine tract by expanded CAG repeats in the ATXN1 gene coding region is associated with SPINOCEREBELLAR ATAXIA 1.


Electronarcosis
Electric Anesthesia
Electrosleep
Electroanesthesia
Anesthesia, Electric

Profound stupor produced by passing an electric current through the brain.


Development of male secondary SEX CHARACTERISTICS in the FEMALE. It is due to the effects of androgenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs.


Maximal Expiratory Flow Volume Curves
Maximal Expiratory Flow-Volume Curves

Curves depicting MAXIMAL EXPIRATORY FLOW RATE, in liters/second, versus lung inflation, in liters or percentage of lung capacity, during a FORCED VITAL CAPACITY determination. Common abbreviation is MEFV.


Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8

A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins


CD56 Antigens
NKH-1 Antigen
Antigens, CD56
CD56 Antigen
Leu-19 Antigen

The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. It is expressed by all lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors.


Myogenic Regulatory Factor 5
Myogenic Factor 5
Myf5 Transcription Factor

A SKELETAL MUSCLE-specific transcription factor that contains a basic HELIX-LOOP-HELIX MOTIF. It plays an essential role in MUSCLE DEVELOPMENT.


Cobra Neurotoxins
Cobrotoxin
Cobra Neurotoxin Proteins

Toxins, contained in cobra (Naja) venom that block cholinergic receptors; two specific proteins have been described, the small (short, Type I) and the large (long, Type II) which also exist in other Elapid venoms.


An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.


Mouse, C57BL
Mouse, Inbred C57BL
Mice, C57BL
Mice, Inbred C57BL

One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases.


Double-Balloon Enteroscopy
Push-and-Pull Enteroscopy

Endoscopy of the small intestines accomplished while advancing the endoscope into the intestines from the stomach by alternating the inflation of two balloons, one on an innertube of the endoscope and the other on an overtube.


Corpora Allata
Corpus Cardiacum
Corpus Allatum

Paired or fused ganglion-like bodies in the head of insects. The bodies secrete hormones important in the regulation of metamorphosis and the development of some adult tissues.


Munchhausen Syndrome
Munchausen Syndrome
Syndrome, Hospital-Addiction
Hospital-Addiction Syndrome

A factitious disorder characterized by habitual presentation for hospital treatment of an apparent acute illness, the patient giving a plausible and dramatic history, all of which is false.


Amplified Fragment Length Polymorphism Analysis

The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.


High-Temperature Requirement A Serine Peptidase 2

A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.


Enterobacter aerogenes
Klebsiella mobilus
Aerobacter aerogenes
Klebsiella aerogenes

Gram-negative, capsulated, gas-producing rods found widely in nature. Both motile and non-motile strains exist. The species is closely related to KLEBSIELLA PNEUMONIAE and is frequently associated with nosocomial infections


Dynamin-2
DYNII Dynamin
Dynamin 2
DNM2 Protein
Dynamin II
DynII Protein

A subtype of dynamin found ubiquitously expressed in a variety of tissues.


Physiologically active prostaglandins found in many tissues and organs. They are potent pressor substances and have many other physiological activities.


Plasmodium falciparum Merozoite Precursor Surface Coat Protein

Major Merozoite Surface Protein Precursor

A surface protein found on Plasmodium species which induces a T-cell response. The antigen is polymorphic, sharing amino acid sequence homology among PLASMODIUM FALCIPARUM; PLASMODIUM CHABAUDI; PLASMODIUM VIVAX; and PLASMODIUM YOELII.


Viral disease of horses caused by the equine infectious anemia virus (EIAV; INFECTIOUS ANEMIA VIRUS, EQUINE). It is characterized by intermittent fever, weakness, and anemia. Chronic infection consists of acute episodes with remissions.


Sex Change Surgery
Sex Reassignment Surgery
Gender Change Surgery
Gender Confirmation Surgery
Gender Reassignment Surgery

Surgical treatments used to change the physiological sexual characteristics of an individual.


Estradiol Receptor
Receptors, Estradiol
Estradiol Receptors

Cytoplasmic proteins that bind estradiol, migrate to the nucleus, and regulate DNA transcription.


Dactylolysis Spontanea
Ainhum
Spontaneous Dactylolysis

Spontaneous autoamputation of the fourth or fifth toe.


An adverse effect occurring with a medical treatment that is not attributable to the actions of the treatment.


Algae, Golden-Brown
Chrysophyceae
Golden Algae
Chrysophyta

A family of microscopic freshwater EUKARYOTA, commonly known as golden algae. They share many features with the BROWN ALGAE but are planktonic rather than benthic. Though most are photosynthetic, they are not considered truly autotrophic since they can become facultatively heterotrophic in the absence of adequate light. In this state they can feed on BACTERIA or DIATOMS.


Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.


Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.


The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.


Chloramphenicol O-Acetyltransferase
Chloramphenicol Transacetylase
CAT Enzyme
Chloramphenicol Acetyltransferase

An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.


An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP. The enzyme, also called stringent factor, is located in the relA gene in stringent strains of bacteria. The above synthesis is induced by mRNA and uncharged tRNA which is bound to the aminoacyl-t-RNA binding site of the ribosome by a codon-specific association. EC 2.7.6.5.


Neurotrophic Tyrosine Kinase Receptor Type 3

Receptor, Neurotrophic Tyrosine Kinase Type 3

A protein-tyrosine kinase receptor that is specific for NEUROTROPHIN 3. It is widely expressed in nervous tissue and may play a role in mediating the effects of NEUROTROPHIN 3 on the proliferation and differentiation of NEURONS.


The underlying rationale or theoretical basis for the principles of MEDICINE.


Oncostatin M Receptors
Oncostatin M Receptor
Receptor, Oncostatin M
Receptors, Oncostatin M

Cell surface receptors with specificity for ONCOSTATIN M. Two subtypes of receptors have been identified and are defined by their subunit composition.


Chondroitinsulfatase
Chondroitin Sulfohydrolase
Chondroitinsulfatases

A group of enzymes that catalyze the hydrolysis of various sulfate bonds of chondroitin sulfate. EC 3.1.6.-.


Anorectal Anomalies
Anorectal Stenosis
Anorectal Atresia
Anorectal Malformation
Anorectal Malformations

Congenital defects in the anus and the rectum often involving the urinary and genital tracts.


abl Proto-Oncogene Proteins
Proto-Oncogene Proteins abl
Proto-Oncogene Proteins c-abl
c-abl Proteins
abl Proto-Oncogene Products

Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.


Leukocyte Depletion Procedures
Leukocyte Reduction Filtration
Leukocyte Removal Procedures
Leukocyte Reduction Procedures

The removal of LEUKOCYTES from BLOOD to reduce BLOOD TRANSFUSION reactions and lower the chance of transmitting VIRUSES. This may be performed by FILTRATION or by CYTAPHERESIS.


Procedures concerned with the remedial treatment or prevention of diseases.


Abortifacient Agents, Nonsteroidal
Abortifacient Agents, Non-Steroidal

Non-steroidal chemical compounds with abortifacient activity.


A left-handed double helix of DNA. Its name derives from its narrow zigzag structure that is the least twisted and thinnest form of DNA. Z-DNA forming regions within the GENOME may play an important role in GENE EXPRESSION REGULATION.


Denervation, Autonomic
Autonomic Denervation

The removal or interruption of some part of the autonomic nervous system for therapeutic or research purposes.


A non-heme iron-sulfur protein isolated from Clostridium pasteurianum and other bacteria. It is a component of NITROGENASE along with molybdoferredoxin and is active in nitrogen fixation.


Delta Sleep-Inducing Peptide
Delta-Sleep Peptide
Delta-Sleep-Inducing Peptide
Delta-Sleep-Inducing-Peptide
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
DSIP
Delta Sleep Inducing Peptide

A nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals. In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.


Perceptual Completion Phenomena
Perceptual Closure
Gestalt Law of Closure

The tendency to perceive an incomplete pattern or object as complete or whole. This includes the Gestalt Law of Closure.


Advanced Oxidation Protein Products
AOPPs

A class of dityrosine-containing protein-derived molecules formed by OXIDATIVE STRESS. Their accumulation in plasma is associated with certain pathological conditions.


Ura-DNA Glycosidase
Uracil-DNA Glycosylase
Uracil N-Glycosylase
Ura-DNA Glycosylase
Uracil N-Glycosidase
Ung DNA Glycosylase
Uracil DNA Glycosylase
Uracil-DNA Glycosidase

An enzyme that catalyzes the HYDROLYSIS of the N-glycosidic bond between sugar phosphate backbone and URACIL residue during DNA synthesis.


Analysis, Least-Squares
Rietveld Refinement
Least Squares
Least-Squares Analysis

A least squares analysis that minimizes the differences between the calculated and measured values by adjusting the parameters needed to describe the model. It is used for POWDER DIFFRACTION crystallography.


Hydrogen Peroxide (H2O2)
Hydroperoxide
Hydrogen Peroxide
Superoxol
Perhydrol
Oxydol

A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.


Liposomal Acid Lipase Deficiency, Wolman Type

Acid Cholesteryl Ester Hydrolase Deficiency, Wolman Type

The severe infantile form of inherited lysosomal lipid storage diseases due to deficiency of acid lipase (STEROL ESTERASE). It is characterized by the accumulation of neutral lipids, particularly CHOLESTEROL ESTERS in leukocytes, fibroblasts, and hepatocytes. It is also known as Wolman's xanthomatosis and is an allelic variant of CHOLESTEROL ESTER STORAGE DISEASE.


Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.


Deoxyribodipyrimidine Photolyase
Photolyase
Photolyases
DNA Photoreactivating Enzyme
DNA Photolyase
Photoreactivating Enzyme
Deoxyribodipyrimidine Photo-Lyase
DNA Photolyases

An enzyme that catalyzes the reactivation by light of UV-irradiated DNA. It breaks two carbon-carbon bonds in PYRIMIDINE DIMERS in DNA.


Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.


Cottontail rabbit papillomavirus
Shope Papilloma Virus
Papillomavirus sylvilagi
Papilloma Virus, Shope

The type species of KAPPAPAPILLOMAVIRUS. It is reported to occur naturally in cottontail rabbits in North America.


Hyperlipemia, Combined Fat And Carbohydrate-Induced

Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial

A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .


Clostridium botulinum C
Clostridium botulinum type C

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.


Nuclear Receptor Subfamily 4, Group A, Member 3

Translocated in Extraskeletal Chondrosarcoma Protein

An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor family. It was originally identified in NERVE CELLS, however it may play regulatory roles in a variety of other tissues.


Decalcification, Pathological
Decalcification, Pathologic
Pathologic Decalcification

The loss of calcium salts from bones and teeth. Bacteria may be responsible for this occurrence in teeth. Old age may be a factor contributing to calcium loss, as is the presence of diseases such as rheumatoid arthritis.


Idiotypes, Immunoglobulin
Immunoglobulin Idiotypes
Ig Idiotypes

Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.


Neopyrithiamine
Pyrithiamine
Heterovitamin B 1

A thiamine antagonist due to its inhibition of thiamine pyrophosphorylation. It is used to produce thiamine deficiency.


Ethanediols
Dihydroxyethanes
Ethylene Glycols

An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.


Air Pollutants, Occupational
Occupational Air Pollutants

Toxic air-borne matter related to work performed They are usually produced by the specific nature of the occupation.


Carboxyanhydrase Inhibitors
Carbonic Anhydrase Inhibitors
Carbonate Dehydratase Inhibitors

A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.


A plant genus of the family POACEAE that many people consider to be a weed.


Transtheoretical Model of Behavior Change

An interdisciplinary scientific approach to the study of complex interactions among biological, social, behavioral and environmental factors.


A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)


Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.


Abnormal Erythrocytes
Erythrocytes, Abnormal

Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.


SH2 Domain-Containing Protein Tyrosine Phosphatases

Src Homology-2 (SH2) Domain-Containing Phosphatases

A subcategory of protein tyrosine phosphatases that contain SH2 type SRC HOMOLOGY DOMAINS. Many of the proteins in this class are recruited to specific cellular targets such as a cell surface receptor complexes via their SH2 domain.


Malignant Cystosarcoma Phyllodes
Phyllodes Tumor
Cystosarcoma Phylloides
Cystosarcoma Phyllodes

A type of connective tissue neoplasm typically arising from intralobular stroma of the breast. It is characterized by the rapid enlargement of an asymmetric firm mobile mass. Histologically, its leaf-like stromal clefts are lined by EPITHELIAL CELLS. Rare phyllodes tumor of the prostate is also known.


Hospital Nursing Service
Service, Hospital Nursing
Nursing Service, Hospital

The hospital department which is responsible for the organization and administration of nursing activities.


Helplessness, Learned
Learned Helplessness

Learned expectation that one's responses are independent of reward and, hence, do not predict or control the occurrence of rewards. Learned helplessness derives from a history, experimentally induced or naturally occurring, of having received punishment/aversive stimulation regardless of responses made. Such circumstances result in an impaired ability to learn. Used for human or animal populations. (APA, Thesaurus of Psychological Index Terms, 1994)


Cholesteryl Ester Storage Disease
Cholesterol Ester Storage Disease

An autosomal recessive disorder caused by mutations in the gene for acid lipase (STEROL ESTERASE). It is characterized by the accumulation of neutral lipids, particularly CHOLESTEROL ESTERS in leukocytes, fibroblasts, and hepatocytes.


Hospitals, Maternity
Maternity Hospitals

Special hospitals which provide care to women during pregnancy and parturition.


A plant genus of the family ROSACEAE. Members contain procyanidins and TANNINS.


Magnesium oxide (MgO). An inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.


A mammalian beta-hexosaminidase isoform that is comprized of hexosaminidase beta subunits. Deficiency of hexosaminidase B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE.


Prenatal Exposure Delayed Effects
Delayed Effects, Prenatal Exposure
Late Effects, Prenatal Exposure

The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.


Adenosine Phosphosulfate
Adenosine 5'-Phosphosulfate
Adenylyl Sulfate
Phospho-Adenylsulfate

5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS.


Ciba 47175-BA
Calcitrin
Calcitonin
Eel Calcitonin
Calcitonin(1-32)
Thyrocalcitonin

A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.


An incision made during a surgical procedure.


A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)