Peroxisome-Targeting Signal 1 Receptor
Peroxisome Receptor 1
PTS1 Receptors
PTS1 Receptor
Peroxisomal Biogenesis Factor 5
Peroxin-5
Peroxin PEX5

A cytoplasmic receptor and peroxin that contains a series of TETRATRICOPEPTIDE REPEATS and binds to PEROXISOME TARGETING SIGNAL 1 (SKL-type). It is essential for protein import into PEROXISOMES; mutations in the PEX5 gene are associated with PEROXISOMAL DISORDERS such as ZELLWEGER SYNDROME.


Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.


Infections, Bacterial Ocular
Bacterial Eye Infections
Ocular Infections, Bacterial
Eye Infections, Bacterial
Bacterial Ocular Infections
Infections, Bacterial Eye

Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.


Actin-Related Protein 3
ACTR3 Protein
Arp3 Protein

A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.


CYP2B6 Inhibitors
Cytochrome P-450 CYP2B6 Inhibitors
P450 CYP2B6 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2B6.


Mouse, NZB
Mouse, Inbred NZB
Mice, NZB
Mice, Inbred NZB

An inbred strain of mouse that is widely used as a model for AUTOIMMUNE DISEASES such as SYSTEMIC LUPUS ERYTHEMATOSUS.


Immune-mediated inflammation of the PITUITARY GLAND often associated with other autoimmune diseases (e.g., HASHIMOTO DISEASE; GRAVES DISEASE; and ADDISON DISEASE).


Encrustations formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedded in an EXTRACELLULAR POLYMERIC SUBSTANCE MATRIX that is secreted by the microbes. They occur on body surfaces such as teeth (DENTAL DEPOSITS); inanimate objects, and bodies of water. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and anti-fouling agents.


Infections, Erysipelothrix
Erysipelothrix Infections

Infections with bacteria of the genus ERYSIPELOTHRIX.


Cell Communication
Cell Interaction
Cell-to-Cell Interaction

Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.


An order of ameboid protozoa that is commonly uninucleate and possess mitochondria. Most organisms are nonpathogenic.


A type I keratin that is found associated with the KERATIN-4 in the internal stratified EPITHELIUM. Defects in gene for keratin 13 cause HEREDITARY MUCOSAL LEUKOKERATOSIS.


Voice Hoarseness
Hoarseness
Hoarseness of Voice
Neurogenic Hoarseness

An unnaturally deep or rough quality of voice.


Uptake Inhibitors, Dopamine
Inhibitors, Dopamine Uptake
Inhibitors, Dopamine Reuptake
Reuptake Inhibitors, Dopamine
Dopamine Uptake Inhibitors
Dopamine Reuptake Inhibitors

Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.


Pyridine Nucleotide Transhydrogenase, B-Specific

A NADP transhydrogenase subtype found in certain types of BACTERIA. This transhydrogenase uses a mechanism that transfers hydrogen to the B side of the NAD(+) or NADP(+) ring structure.


Leukocyte Adherence Inhibition Test
LAI Test

Test for cell-mediated antitumor immunity and related serum blocking factors based on the finding that leukocytes from cancer patients, but not from controls, when mixed in vitro with antigenic extracts of tumors of the same histological type, undergo a diminution in their normal adherence to glass surfaces. Sera from tumor-bearing patients block the LAI reaction of their own leukocytes or those of other patients with the same type of tumor.


Blood Pressure, Low
Low Blood Pressure
Vascular Hypotension
Hypotension
Hypotension, Vascular

Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.


A plant genus in the family LILIACEAE generally growing in temperate areas. The word lily is also used in the common names of many plants of other genera that resemble true lilies. True lilies are erect perennial plants with leafy stems, scaly bulbs, usually narrow leaves, and solitary or clustered flowers.


Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.


Accidents, Traffic
Traffic Crashes
Traffic Accidents
Traffic Collisions

Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.


Steroid Metabolic Diseases, Inborn
Congenital Errors of Steroid Metabolism
Steroid Metabolism, Inborn Errors
Inborn Errors of Steroid Metabolism

Errors in metabolic processing of STEROIDS resulting from inborn genetic mutations that are inherited or acquired in utero.


Aspartylglucosamidase Deficiency
Aspartylglycosaminuria
Glycoasparaginase Deficiency
AGA Deficiency
Aspartylglucosaminuria

A recessively inherited, progressive lysosomal storage disease caused by a deficiency of GLYCOSYLASPARAGINASE activity. The lack of this enzyme activity results in the accumulation of N-acetylglucosaminylasparagine (the linkage unit of asparagine-linked glycoproteins) in LYSOSOMES.


Immunity, Maternally Acquired
Neonatal Immunity, Maternally-Acquired
Immunity, Maternally-Acquired
Maternally-Acquired Immunity
Fetal Immunity, Maternally-Acquired

Resistance to a disease-causing agent induced by the introduction of maternal immunity into the fetus by transplacental transfer or into the neonate through colostrum and milk.


A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.


Glycerol Glycerine 1,2,3-Trihydroxypropane Glycerin

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.


Transference of multiple tissues, such as muscle, bone, nerve, and skin, as a functional unit for reconstructive purposes. Blood supply to the transplanted tissues is maintained throughout the transplantation procedure with minimal ischemia. Maintenance of vascularity in the graft promotes its viability, function, and survival in the recipient.


CUG Triplet Repeat, RNA-Binding Proteins

A family of RRM proteins which contain two N-terminal RNA RECOGNITION MOTIF (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 amino acids between the second and third RRM domains. They regulate pre-mRNA ALTERNATIVE SPLICING and also function in RNA EDITING and PROTEIN BIOSYNTHESIS.


The cactus plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. Cacti are succulent perennial plants well adapted to dry regions.


Small kinetoplastid mitochondrial RNA that plays a major role in RNA EDITING. These molecules form perfect hybrids with edited mRNA sequences and possess nucleotide sequences at their 5'-ends that are complementary to the sequences of the mRNA's immediately downstream of the pre-edited regions.


Posterior Capsule, Lens
Posterior Capsule of the Lens

The posterior aspect of the casing that surrounds the natural CRYSTALLINE LENS.


Pathological Fractures
Fractures, Spontaneous
Fracture, Pathologic
Fractures, Pathologic
Fracture, Pathological
Pathological Fracture
Fractures, Pathological

Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)


Anemia, Leukoerythroblastic
Anemia, Myelophthisic

Anemia characterized by appearance of immature myeloid and nucleated erythrocytes in the peripheral blood, resulting from infiltration of the bone marrow by foreign or abnormal tissue.


23S rRNA
23S Ribosomal RNA
RNA, Ribosomal, 23S

Constituent of 50S subunit of prokaryotic ribosomes containing about 3200 nucleotides. 23S rRNA is involved in the initiation of polypeptide synthesis.


NSC-26980
Mutamycin
Mitomycin-C
Ametycine
Mitocin-C
Mitomycin
Mitomycin C

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.


Examination, Neurologic
Neurologic Examination
Neurological Examination

Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.


Zoonotic Infectious Diseases
Zoonotic Diseases
Zoonotic Infections
Zoonoses

Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.


Semi-Metals
Intermediate Metals
Metalloids

A class of nonmetals such as arsenic that have some of the chemical properties of a metal.


Dihydrodiethylstilbestrol
Hexestrol, (R*,S*)-Isomer
Hexestrol, (S-(R*,R*))-Isomer
Hexestrol, (R-(R*,R*))-Isomer
Hexestrol
Hexestrol, (R*,R*)-(+-)-Isomer

A synthetic estrogen that has been used as a hormonal antineoplastic agent.


Acetylthiocholinesterase
Acetylcholine Hydrolase
Acetylcholinesterase

An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.


A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)


A membrane glycoprotein and ANGIOGENESIS FACTOR that is expressed by cells of the VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; and MONOCYTES. It functions as a co-receptor for TRANSFORMING GROWTH FACTOR BETA and modulates CELL ADHESION. Mutations in the endoglin gene are associated with cases of HEREDITARY HEMORRHAGIC TELANGIECTASIA.


Lipocortin IV
Calelectrin 32-kDa
Placental Anticoagulant Protein II
Annexin IV
Annexin A4

Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.


Helicopter Ambulances
Air Ambulances
Ambulances, Air
Emergency Helicopters

Fixed-wing aircraft or helicopters equipped for air transport of patients.


Insulin-Like Growth Factor Binding Proteins

A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)


Antigens, CD50
CDw50 Antigen
ICAM3
Intercellular Adhesion Molecule-3
ICAM-3
CD50 Antigen

A membrane glycoprotein and cell adhesion molecule expressed by LEUKOCYTES that contains multiple Ig-like domains. It is a ligand for LFA-1 (integrin alphaLbeta2) and integrin alpha-D/beta-2. Its interaction with LFA-1 may play a role in the PHAGOCYTOSIS of NEUTROPHILS by MACROPHAGES following APOPTOSIS.


Olfactory Fila
First Cranial Nerve
Nervus Olfactorius
Cranial Nerve I
Fila Olfactoria
Olfactory Nerve

The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB.


Ecological and Environmental Processes
Ecological and Environmental Phenomena
Ecological and Environmental Concepts

Ecological and environmental entities, characteristics, properties, relationships and processes.


Total Proctocolectomy with Ileal Pouch Anal Anastomosis

A surgical procedure involving the excision of the COLON and RECTUM and the formation of an ILEOANAL RESERVOIR (pouch). In patients with intestinal diseases, such as ulcerative colitis, this procedure avoids the need for an OSTOMY by allowing for transanal defecation.


Alanine Dehydrogenase
L-Alanine Dehydrogenase

An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.


Neisseria meningitidis, Serogroup Y
Meningococcus, Serogroup Y
Meningococci, Serogroup Y

Strains of Neisseria meningitidis which, in the United States, causes disease in mostly adults and the elderly. Serogroup Y strains are associated with PNEUMONIA.


Sandomigran BC-105 Pizotifen Pizotyline Polomigran

Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.


Kauranes
Diterpenes, Kaurane
Ent-Kaurenes
Kaurane Diterpenoids
Ent-Kauranes

A group of DITERPENES cyclized into four rings.


Antioxidant; also a post-harvest dip to prevent scald on apples and pears.


Esterase 8
Esterase 6A
Procaine Esterase
Hydrolase S
Non-specific Carboxylesterase
Carboxylate Esterase
Carboxylesterase B
Esterase ES-1A
Isocarboxazid amidase
B-esterase
CAP-hydrolyzing Enzyme
Carboxylic Ester Hydrolase
Carboxyesterase
Ali-esterase
Carboxylesterase
Esterase 10
Non-specific Esterase
Esterase 3
Naproxen Esterase
Capsaicin-Hydrolyzing Enzyme
Nonspecific Esterase
Esterase 13
Carboxylester Lipase

Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.


Tyrosine Kinase-type Cell Surface Receptor HER2

A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and  heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.


Ophthalmoplegia, Chronic Progressive External

Chronic Progressive External Ophthalmoplegia

A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)


Renal Tubular Transport, Inborn Errors
Kidney Tubular Transport, Inborn Errors
Renal Tubular Transport Errors
Renal Tubular Transport, Inborn Error
Kidney Tubular Transport, Inborn Error

Genetic defects in the selective or non-selective transport functions of the KIDNEY TUBULES.


Peripheral Equipment, Computer
Peripheral Devices, Computer
Computer Peripherals

Various units or machines that operate in combination or in conjunction with a computer but are not physically part of it. Peripheral devices typically display computer data, store data from the computer and return the data to the computer on demand, prepare data for human use, or acquire data from a source and convert it to a form usable by a computer. (Computer Dictionary, 4th ed.)


Tumor Necrosis Factor Ligand Superfamily Member 12

A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.


Mastalgia
Mastodynia
Breast Pain
Mammalgia

Pain in the breast generally classified as cyclical (associated with menstrual periods), or noncyclical, i.e. originating from the breast or nearby muscles or joints, ranging from minor discomfort to severely incapacitating.


A plant genus of the family VERBENACEAE. Members contain verbenachalcone (dimeric dihydrochalcone), iridoids, and phenylethanoids.


Immunoglobulin-like Transcript 2 Protein

Leukocyte Immunoglobulin-like Receptor B1

A receptor for HISTOCOMPATIBILITY ANTIGENS CLASS I that also functions as a receptor for the UL18 protein, an MHC class I homolog expressed by human CYTOMEGALOVIRUS. It consists of four Ig-like C2 domains and is expressed primarily by B-cells and MONOCYTES, as well as DENDRITIC CELLS; its interaction with MHC1 functions to down-regulate the immune response.


Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.


Neuropathies, Amyloid
Amyloid Polyneuropathies
Amyloid Neuropathy, Secondary
Amyloid Neuropathies

Disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. Familial, primary (nonfamilial), and secondary forms have been described. Some familial subtypes demonstrate an autosomal dominant pattern of inheritance. Clinical manifestations include sensory loss, mild weakness, autonomic dysfunction, and CARPAL TUNNEL SYNDROME. (Adams et al., Principles of Neurology, 6th ed, p1349)


Herpesvirus 2, Gallid
Gallid Herpesvirus 2
Marek's Disease Herpesvirus 1
Marek's Disease Virus Serotype 1
Fowl Paralysis Virus
Herpesvirus 2 (gamma), Gallid
Neurolymphomatosis Virus
Marek Disease Herpesvirus 1

The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.


Hospitals, University
University Hospitals

Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.


Discharge of URINE, liquid waste processed by the KIDNEY, from the body.


Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.


A relatively rare smooth muscle tumor found most frequently in the wall of the gastrointestinal tract, especially in the stomach. It is similar to other smooth muscle tumors but may become very large and hemorrhage and exhibit small cystic areas. Simple excision is almost always curative. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1354)


Dipeptidyl Peptidase A
Antigens, CD143
CD143 Antigens
Kininase II
Carboxycathepsin
Angiotensin I-Converting Enzyme
Peptidyl-Dipeptidase A
Kininase A
Angiotensin Converting Enzyme

A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992)


1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester.


Hospitals controlled by the county government.


A surgical technique to correct REFRACTIVE ERRORS of the EYE, such as MYOPIA and ASTIGMATISM. In this method, a flap of CORNEAL EPITHELIUM is created by exposure of the area to dilute alcohol. The flap is lifted and then replaced after laser ablation of the subepithelial CORNEA.


Neoplastic Syndromes, Hereditary
Cancer Syndromes, Hereditary
Hereditary Cancer Syndromes
Hereditary Neoplastic Syndromes

The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.


Cellular Encapsulation
Cell Microencapsulation
Cell Encapsulation

The encapsulation of cells into semi-permeable microcapsules or MICROSPHERES that permits protection of encapsulated cells and allows passage of essential nutrients and release of a therapeutic product (e.g. INSULIN).


Maturation of Spermatozoa
Sperm Maturation

The maturing process of SPERMATOZOA after leaving the testicular SEMINIFEROUS TUBULES. Maturation in SPERM MOTILITY and FERTILITY takes place in the EPIDIDYMIS as the sperm migrate from caput epididymis to cauda epididymis.


Transfer RNA, Glu
tRNAGlu
Glutamic Acid-Specific tRNA
RNA, Transfer, Glu
tRNA(Glu)

A transfer RNA which is specific for carrying glutamic acid to sites on the ribosomes in preparation for protein synthesis.


Human Embryonic Kidney Cell Line 293
293T Cells
HEK293 Cells
Human Kidney Cell Line 293
HEK 293 Cell Line
HEK 293 Cells

A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.


Homaridae
Homarus
Nephropidae
Clawed Lobsters
Lobsters, Clawed

Family of large marine CRUSTACEA, in the order DECAPODA. These are called clawed lobsters because they bear pincers on the first three pairs of legs. The American lobster and Cape lobster in the genus Homarus are commonly used for food.


A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.


Splenic Infarcts
Splenic Infarction
Infarct of the Spleen
Splenic Infarct

Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)


A recombinant humanized monoclonal antibody fragment that binds VEGF-A to prevent its binding to VEGFR-1 and VEGFR-2 receptors. This activity reduces vessel permeability and angiogenesis in the treatment of neovascular age-related MACULAR DEGENERATION.


APOBEC-3G Protein
APOBEC-Related Cytidine Deaminase
APOBEC3G Protein
APOBEC-3G dC-dU Editing Enzyme
APOBEC-Related Protein
APOBEC-3G Deaminase
CEM15 Protein
APOBEC3G Deaminase

An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.


May-Thurner Syndrome
Iliocaval Compression Syndrome
Cockett Syndrome
Iliac Vein Compression Syndrome

A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation.


CoA Transferases
Coenzyme A-Transferases
Acyl-CoA-Transferases
CoA-Transferases
Coenzyme A Transferases

Enzymes which transfer coenzyme A moieties from acyl- or acetyl-CoA to various carboxylic acceptors forming a thiol ester. Enzymes in this group are instrumental in ketone body metabolism and utilization of acetoacetate in mitochondria. EC 2.8.3.


Use of nursing bottles for feeding. Applies to humans and animals.


Large Neutral Amino Acid Transporter (LNAA)

A sodium-independent neutral amino acid transporter system with specificity for large amino acids. One of the functions of the transporter system is to supply large neutral amino acids to the brain.


Ribonucleic acid in helminths having regulatory and catalytic roles as well as involvement in protein synthesis.


Amide Synthases
Acid-Amide Ligases
Acid-Ammonia Ligases

Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.


Fibrous Dysplasia of Bone
Jaffe-Lichtenstein Disease
Fibrocystic Dysplasia of Bone
Osteitis Fibrosa Disseminata
Fibrocartilaginous Dysplasia of Bone

A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).


Guanine Polynucleotides
Polyguanylic Acids
Poly G

A group of guanine ribonucleotides in which the phosphate residues of each guanine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.


Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).


Antineoplastic Agents, Phytogenic
Antineoplastics, Phytogenic
Antineoplastics, Botanical

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.


Recti Abdominis
Rectus Muscle of Abdomen
Rectus Abdominis

A long flat muscle that extends along the whole length of both sides of the abdomen. It flexes the vertebral column, particularly the lumbar portion; it also tenses the anterior abdominal wall and assists in compressing the abdominal contents. It is frequently the site of hematomas. In reconstructive surgery it is often used for the creation of myocutaneous flaps. (From Gray's Anatomy, 30th American ed, p491)


Bacteria, Purple
Proteobacteria
Purple Bacteria

A phylum of bacteria consisting of the purple bacteria and their relatives which form a branch of the eubacterial tree. This group of predominantly gram-negative bacteria is classified based on homology of equivalent nucleotide sequences of 16S ribosomal RNA or by hybridization of ribosomal RNA or DNA with 16S and 23S ribosomal RNA.


Negative Body Image
Body Dissatisfaction
Body Image Dissatisfaction

Person’s negative thoughts about his or her own body.  This includes judgements about size and shape, muscle tone and generally involves a discrepancy between one's own body type and an ideal body type. (Grogan, 2008)


Urology Departments, Hospital
Hospital Urology Department
Department, Hospital Urology
Urology Department, Hospital

Hospital department responsible for the administration and provision of diagnostic and therapeutic services for the urologic patient.


C5a Receptors
Receptor, Anaphylatoxin C5a
Receptor, Complement 5a
CD88 Antigen
Anaphylatoxin C5a Receptor
Complement 5a Receptor
CD88 Antigens
Antigens, CD88

A G-protein-coupled receptor that signals an increase in intracellular calcium in response to the potent ANAPHYLATOXIN peptide COMPLEMENT C5A.


Poisoning, CCl4
CCl4 Poisoning
Poisoning, Carbon Tetrachloride
Carbon Tetrachloride Poisoning

Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.


Media added to a vaccine for a specific purpose. These include: preservatives to prevent contamination, adjuvants to stimulate a stronger immune response, and stabilizers. (From https://www.cdc.gov/vaccines pubs/pinkbook/downloads/appendices/b/excipient-table-2.pdf)


Nursing, Emergency
Nursing, Emergency Room
Emergency Room Nursing
Emergency Nursing

The specialty or practice of nursing in the care of patients admitted to the emergency department.


Evolution, Planetary
Planetary Evolution

Creation and development of bodies within solar systems, includes study of early planetary geology.


Tumor Necrosis Factor Ligand Superfamily Member 3

A membrane-bound tumor necrosis family member found primarily on LYMPHOCYTES. It can form a heterotrimer (LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER) with the soluble ligand LYMPHOTOXIN-ALPHA and anchor it to the cell surface. The membrane-bound complex is specific for the LYMPHOTOXIN BETA receptor.


Collectins
Collagenous Lectins
Collectin

A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.


Circulation, Extracorporeal
Extracorporeal Circulation

Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.


BIRDS of the large family Psittacidae, widely distributed in tropical regions and having a distinctive stout, curved hooked bill. The family includes LOVEBIRDS; AMAZON PARROTS; conures; PARAKEETS; and many other kinds of parrots.


H2N2 Virus
Influenza A Virus, H2N2 Subtype

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 2 and neuraminidase 2. The H2N2 subtype was responsible for the Asian flu pandemic of 1957.


Angiopoietin-related Protein
Angiopoietin-like Protein
Angiopoietin-like Proteins

A family of proteins that is structurally similar to ANGIOPOIETINS but do not bind angiopoietin receptors. They are characterized by an amino-terminal coiled-coil domain, a linker region, and a carboxy-terminal FIBRINOGEN-like domain with the exception of ANGPTL8, which lacks the fibrinogen-like domain. They function in a variety of developmental and physiological processes, including INFLAMMATION, lipid metabolism, hematopoietic stem cell activity, and cancer metastasis.


Pregnancy complication where fetal blood vessels, normally inside the umbilical cord, are left unprotected and cross FETAL MEMBRANES. It is associated with antepartum bleeding and FETAL DEATH and STILLBIRTH due to exsanguination.


Substances elaborated by bacteria that have antigenic activity.


Common Carotid Artery
Carotid Artery, Common

The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.


Trimethoprim, Sulfamethoxazole Drug Combination

A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.


Aberrant Tissue
Choristoma
Heterotopic Tissue
Ectopic Tissue

A mass of histologically normal tissue present in an abnormal location.


Leprosy, Multibacillary
Borderline Lepromatous
Multibacillary Leprosy
Midborderline Lepromatous

A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with multibacillary leprosy have six or more lesions with or without positive skin smear results for the causative agent MYCOBACTERIUM LEPRAE. Multibacillary leprosy encompasses borderline lepromatous, midborderline, and lepromatous leprosy.


Veterinary Pathology
Pathology, Veterinary

The field of veterinary medicine concerned with the causes of and changes produced in the body by disease.


Colony Stimulating Factor
Colony-Stimulating Factors
Macrophage-Granulocyte Inducer
Colony-Stimulating Factor
MGI-1
Myeloid Cell-Growth Inducer
Protein Inducer MGI
MGI-1 Protein

Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF).


Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.


Bacillus megatherium
Bacillus megaterium

A species of bacteria whose spores vary from round to elongate. It is a common soil saprophyte.


Receptors, Leukocyte-Adhesion
Leukocyte-Adhesion Receptor
Leukocyte-Adhesion Receptor Family
Leu-CAM Receptor Family
Leukocyte-Adhesion Receptors

Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.


A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.


Vaccines, Combination
Vaccines, Combined

Two or more vaccines in a single dosage form.


Root Canal Obturation
Endodontic Obturation

Phase of endodontic treatment in which a root canal system that has been cleaned is filled through use of special materials and techniques in order to prevent reinfection.


3,5-Cyclic GMP Phosphodiesterase
3',5'-Cyclic GMP Phosphodiesterase
3,5-Cyclic GMP 5-Nucleotidohydrolase
3',5'-Cyclic-GMP Phosphodiesterases
3',5'-Cyclic GMP 5'-Nucleotidohydrolase
3',5'-Cyclic-GMP Phosphodiesterase

Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.


A 513-kDa protein synthesized in the LIVER. It serves as the major structural protein of low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). It is the ligand for the LDL receptor (RECEPTORS, LDL) that promotes cellular binding and internalization of LDL particles.


A PRENATAL ULTRASONOGRAPHY finding of excessively dense fetal bowel due to MECONIUM buildup.


TcR delta Genes
Genes, T-Cell Receptor delta
T-Cell Receptor delta-Chain Genes
T-Cell Receptor delta Genes

DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus.


Uridine-Cytidine Kinase
Cytidine Kinase
Uridine Kinase

An enzyme that catalyzes the phosphorylation of uridine and cytidine to uridine 5'-phosphate and cytidine 5'-phosphate, respectively. ATP, dUTP, dGTP, and dATP are effective phosphate donors. EC 2.7.1.48.


Theca Externa
Theca Cells
Ovarian Interstitial Cells
Theca Interna

The portion of the theca adjacent to the stroma of the OVARY.


Melanoma Growth Stimulatory Activity, alpha Protein

A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.


Infections, Dictyocaulus
Dictyocauliasis
Dictyocaulus Infections

Infection with nematodes of the genus DICTYOCAULUS. In deer, cattle, sheep, and horses the bronchi are the site of infestation.


A large and diverse order of dicotyledonous flowering plants in the subclass DILLENIIDAE. Most members have weakly fused petals and radially symmetric flowers which form fruit capsules and thin seed coats. Members also contain IRIDOIDS, compounds which protect against herbivores. Common examples of the ericales are economically important species such as TEA, PERSIMMON, BLUEBERRY, BRAZIL NUTS,  azalea, CRANBERRIES, and RHODODENDRON.


A mixture of several closely related glycosidic antibiotics obtained from Actinomyces (or Streptomyces) olivoreticuli. They are used as fluorescent dyes that bind to DNA and prevent both RNA and protein synthesis and are also used as antineoplastic agents.


Drug Resistance, Multiple, Viral
Multiple Antiviral Drug Resistance

The ability of viruses to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutation.


Conducted Energy Weapon Injuries
TASER Injuries
Stun Gun Injuries

The injuries caused by conducted energy weapons such as stun guns, shock batons, and cattle prods.


Orchiopexy
Laparoscopic Orchiopexy
Orchidopexy

A surgical procedure in which an undescended testicle is sutured inside the SCROTUM in male infants or children to correct CRYPTORCHIDISM. Orchiopexy is also performed to treat TESTICULAR TORSION in adults and adolescents.


Vitreous Fluorophotometry
Ocular Fluorophotometry
Fluorophotometry

Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.


Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.


Polynucleotide Adenosine Glycosidase
RNA N-Glycosidase
RNA Glycosylase
Ribosome Inactivating Proteins
RIP (Ribosome Inactivating Proteins)
rRNA N-Glycosylases

N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.


The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.


Lymphocyte Subpopulations
Lymphocyte Subsets

A classification of lymphocytes based on structurally or functionally different populations of cells.


Gipsies Romani Romanies Roma Gypsies Romany

Ethnic group originating in India and entering Europe in the 14th or 15th century.


Distance Counseling
E-Therapy
E-Counseling

Counseling conducted via electronic or other non-face-to-face interactions.


An immunoglobulin which accounts for less than 1% of plasma immunoglobulin. It is found on the membrane of many circulating B LYMPHOCYTES.


Veterinary Legislation
Legislation, Veterinary

Laws and regulations, pertaining to the field of veterinary medicine, proposed for enactment or enacted by a legislative body.


Glutathione Synthase
Glutathione Synthetase

One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of glutathione from gamma-glutamylcysteine and glycine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.3.


The effects, both local and systemic, caused by the bite of SCORPIONS.


Diseases of chimpanzees, gorillas, and orangutans.


Cytostatic Drugs
Cytostatic Agents
Cytostatics

Compounds that inhibit or prevent the proliferation of CELLS.


A plant genus of the family MYRTACEAE. Members contain PHYTOHEMAGGLUTININS.


The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.


Prodromal Symptoms
Prodromal Characteristics
Prodromal Syndromes
Prodromal Signs
Prodromal States
Prodromal Period
Prodromal Stage


A species of helminth commonly called the sheep liver fluke. It occurs in the biliary passages, liver, and gallbladder during various stages of development. Snails and aquatic vegetation are the intermediate hosts. Occasionally seen in man, it is most common in sheep and cattle.


A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.


Hemostatic Disorders, Vascular
Hemostatic Disorders
Vascular Hemostatic Disorders

Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS.


Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.


Drug Repurposing
Drug Rescue
Drug Repositioning

Research involving drugs, small molecules and biologics whose development was abandoned before they could be approved by the UNITED STATES FOOD AND DRUG ADMINISTRATION, to study their potential therapeutic uses.


NK-1 Receptor
Receptors, NK-1
Receptors, Substance P
Substance P Receptor
Substance P Receptors
NK-1 Receptors
Tachykinin Receptor 1
Neurokinin-1 Receptors
SP-P Receptors
Receptors, Neurokinin-1
Neurokinin-1 Receptor
Receptors, SP-P
Substance-P Receptor
SP-P Receptor

A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.


Lanexat
Ro 15-1788
Flumazenil
Romazicon
Anexate
Flumazepil

A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.


Medical Programs, Regional
Programs, Regional Medical
Medical Program, Regional
Program, Regional Medical
Regional Medical Programs

Coordination of activities and programs among health care institutions within defined geographic areas for the purpose of improving delivery and quality of medical care to the patients. These programs are mandated under U.S. Public Law 89-239.


Cultured Neoplastic Cells
Cultured Tumor Cells
Tumor Cells, Cultured
Neoplastic Cells, Cultured

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.


Drug-Induced Akathisia
Acathisia, Drug-Induced
Pseudoakathisia
Akathisia, Tardive
Akathisia, Drug-Induced

A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often described as an inability to resist the urge to move.


Second Messenger Systems
Intracellular Second Messengers
Second Messengers

Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.


Therapy, Language
Language Therapy
Language Training

Rehabilitation of persons with language disorders or training of children with language development disorders.


Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)


Eukaryotic-Translation Initiation Factor 4G

Eukaryotic Translation Initiation Factor 4 gamma

A component of eukaryotic initiation factor-4F that is involved in multiple protein interactions at the site of translation initiation. Thus it may serve a role in bringing together various initiation factors at the site of translation initiation.


Asian Soybean Rust
Phakopsora pachyrhizi

Fungal pathogen which causes Soybean Rust disease in Soybeans (Glycine max).


HLA Class I Histocompatibility Antigen, B-13 alpha Chain

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*13 allele family.


Group of lysosomal storage diseases each caused by an inherited deficiency of an enzyme involved in the degradation of glycosaminoglycans (mucopolysaccharides). The diseases are progressive and often display a wide spectrum of clinical severity within one enzyme deficiency.


HMGY Protein
AT-Hook 1b Protein, High Mobility Group
HMGA1b Protein

An AT-hook motif-containing protein (AT-HOOK MOTIFS) that binds to the minor grove of AT-rich regions of DNA. It is a truncated form of HMGA1a protein that is produced by alternative-splicing of the HMGA1 gene. It may function as an architectural chromatin binding protein that is involved in transcriptional regulation.


Histidine substituted in any position with one or more methyl groups.


Lampreys
Petromyzontiformes
Petromyzontidae
Eels, Lamprey

Order of fish containing one family (Petromyzontidae).


Inbred Strains of Animals
Animals, Inbred Strains
Inbred Strain of Animal
Inbred Animal Strains
Inbred Strains, Animal

Animals produced by the mating of progeny over multiple generations. The resultant strain of animals is virtually identical genotypically. Highly inbred animal lines allow the study of certain traits in a relatively pure form. (Segen, Dictionary of Modern Medicine, 1992)


Chromosomes, Human, 4-5
Chromosomes B
Group B Chromosomes

The large, submetacentric human chromosomes, called group B in the human chromosome classification. This group consists of chromosome pairs 4 and 5.


Dysarthria, Guttural
Dysarthria, Spastic
Dysarthria
Dysarthosis
Dysarthria, Scanning
Dysarthria, Mixed
Dysarthria, Flaccid

Disorders of speech articulation caused by imperfect coordination of pharynx, larynx, tongue, or face muscles. This may result from CRANIAL NERVE DISEASES; NEUROMUSCULAR DISEASES; CEREBELLAR DISEASES; BASAL GANGLIA DISEASES; BRAIN STEM diseases; or diseases of the corticobulbar tracts (see PYRAMIDAL TRACTS). The cortical language centers are intact in this condition. (From Adams et al., Principles of Neurology, 6th ed, p489)


Schools for children usually under five years of age.


Sheath of the eyeball consisting of fascia extending from the OPTIC NERVE to the corneal limbus.


Allelic Loss
Loss of Heterozygosity
Heterozygosity, Loss of

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.


Thiobarbituric Acid Reactive Substances
TBARs

Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.


A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain.  The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.


Renin Substrate Tetradecapeptide
Angiotensinogen
Proangiotensin
Hypertensinogen
Renin-Substrate
Serpin A8

A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities.


Hemodialyser
Blood Dialyzers
Artificial Kidneys
Kidney, Artificial
Blood Dialyser
Renal Dialysis Machine
Hemodialyzers
Kidneys, Artificial
Artificial Kidney

Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE.


Antigens, CD169
CD169 Antigens
Siglec-1
Sialoadhesin
Sialic Acid Binding Ig-like Lectin 1

A sialic acid binding lectin that was originally identified as an adhesion molecule for inflammatory MACROPHAGES and activated MONOCYTES. This protein is the largest known siglec subtype and contains 16 immunoglobulin C2-set domains. It plays a role in cell to cell interactions and interactions with bacteria.


Adolescent Health Services
Health Services, Adolescent
Services, Adolescent Health

Organized services to provide health care to adolescents, ages ranging from 13 through 18 years.


Image Interpretation, Computer-Assisted
Image Interpretation, Computer Assisted

Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.


A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.


CYP 7A
Cytochrome P-450 CYP7
CYP7A
Cholesterol 7-alpha-Monooxygenase
Cholesterol 7alpha-Hydroxylase
Cholesterol 7-alpha-Hydroxylase
Cholesterol-7-Hydroxylase
CYP 7
CYP7
Cytochrome P450 7

A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.


Auditory Brain Stem Implantation
Auditory Brainstem Implantation

Surgical insertion of an electronic hearing device (AUDITORY BRAIN STEM IMPLANTS) with electrodes to the cochlea nucleus in the BRAIN STEM rather than to the inner ear as in COCHLEAR IMPLANTATION.


Ferridextran
Imfergen
Imposil
Dexferrum
Imperon
Norferan
InFed
Hematran
Icar
Feosol
Dextran-Iron Complex
Dextrofer
Iron-Dextran Complex
Imferon

A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)


Microscopy, Phase-Contrast
Phase-Contrast Microscopy

A form of interference microscopy in which variations of the refracting index in the object are converted into variations of intensity in the image. This is achieved by the action of a phase plate.


Pygmy Chimpanzee
Bonobo
Chimpanzee, Pygmy
Pan paniscus

The pygmy chimpanzee, a species of the genus Pan, family HOMINIDAE. Its common name is Bonobo, which was once considered a separate genus by some; others considered it a subspecies of PAN TROGLODYTES. Its range is confined to the forests of the central Zaire basin. Despite its name, it is often of equal size to P. troglodytes.


Carbohydrate Metabolism
Metabolism, Carbohydrate

Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.


Calcium Glycerophosphate
Glycerolphosphates
Glycerophosphates

Any salt or ester of glycerophosphoric acid.


A plant genus of the family CAPRIFOLIACEAE. The common name of "snowberry" is also used for GAULTHERIA.


Hand Antiseptics
Hand Disinfectants
Hand Sanitizers

Preparations used as alternatives or supplements to hand washing with soap and water to destroy microorganisms and prevent transmission of pathogens. The active ingredient may be ETHANOL; 1-PROPANOL; or POVIDONE-IODINE in a gel, foam, or liquid solution.


CRISPR-Associated Protein 9
Cas9 Endonuclease
Cas9 Protein
Cas9 Enzyme

An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9.


Endocrine-Gland-Derived Vascular Endothelial Growth Factor

Vascular Endothelial Growth Factor, Endocrine-Gland-Derived

A vascular endothelial growth factor whose expression is found largely restricted to the GONADS; ADRENAL CORTEX; and PLACENTA. It has similar biological activity to VASCULAR ENDOTHELIAL GROWTH FACTOR-A.


Stimulation, Photic
Photic Stimulation
Visual Stimulation

Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.


Electric Capacitance
Electrical Capacitance
Capacitance, Electrical

The ability of a substrate to retain an electrical charge.


Lung Adenocarcinoma
Adenocarcinoma of Lung

A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.


Fibronectin Receptors
Receptors, Fibronectin

Specific cell surface receptors which bind to FIBRONECTINS. Studies have shown that these receptors function in certain types of adhesive contact as well as playing a major role in matrix assembly. These receptors include the traditional fibronectin receptor, also called INTEGRIN ALPHA5BETA1 and several other integrins.


3,4-Dihydroxyphenylacetic Acid, Monosodium Salt


Burkholderia pseudomallei
Pseudomonas pseudomallei

A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.


Janus Kinase 2
JAK2 Protein Tyrosine Kinase
JAK-2 Protein Tyrosine Kinase

A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.


A genus of bioluminescent marine invertebrates in the family Renillidae, order Pennatulacea, class ANTHOZOA. It contains Renilla LUCIFERASE which oxidizes coelenterazine resulting in LUMINESCENCE.


A naphthalene derivative with carcinogenic action.


Sarcoma, Ewing
Ewing Sarcoma
Ewing's Sarcoma
Ewing's Tumor
Ewing Tumor
Sarcoma, Ewing's

A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.


The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)


Receptors, Laminin
Laminin Receptor
Laminin Receptors

Glycoprotein molecules on the surface of cells that react with or bind to laminin whose function allows the binding of epithelial cells to the basement membrane. The molecular weight of this high-affinity receptor is 67 kD.


Hex A
Hexosaminidase A
beta-N-Acetylhexosaminidase A

A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminidase alpha and hexosaminidase beta subunits. Deficiency of hexosaminidase A due to mutations in the gene encoding the hexosaminidase alpha subunit is a case of TAY-SACHS DISEASE. Deficiency of hexosaminidase A and HEXOSAMINIDASE B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE.


Ninjin
Jen Shen
Panax ginseng
Renshen
Shinseng
Schinseng
Panax
Ginseng

An araliaceous genus of plants that contains a number of pharmacologically active agents used as stimulants, sedatives, and tonics, especially in traditional medicine. Sometimes confused with Siberian ginseng (ELEUTHEROCOCCUS).


Viral Envelope Glycoprotein gp55 (Friend Virus)

Viral Envelope Glycoprotein gPr90 (Murine Leukemia Virus)

Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.


Lown-Ganong-Levine Syndrome
Short PR-Normal QRS Complex Syndrome

A form of ventricular pre-excitation characterized by a short PR interval and a normal QRS complex. In this syndrome, the atrial impulse conducts via the JAMES FIBERS which connect the atrium to BUNDLE OF HIS bypassing the upper ATRIOVENTRICULAR NODE. HEART VENTRICLES are depolarized normally through the His-Purkinje system.


Respiratory Aspiration
Aspiration, Respiratory

Inhaling liquid or solids, such as stomach contents, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA.


Public Health Service
USPHS
Public Health Service (U.S.)
United States Public Health Service
United States. Public Health Service

A constituent organization of the DEPARTMENT OF HEALTH AND HUMAN SERVICES concerned with protecting and improving the health of the nation.


Preimplantation Screening
Diagnosis, Preimplantation
Preimplantation Diagnosis
Diagnosis, Preimplantation Genetic
Preimplantation Genetic Diagnosis

Performing various procedures and tests on the the OVUM; ZYGOTE; or BLASTOCYST, prior to implantation, for the detection of diseases.


Dimethylphenylpiperazinium
1,1-Dimethyl-4-phenylpiperazine Iodide
Dimethylphenylpiperazinium Iodide
DMPP

A selective nicotinic cholinergic agonist used as a research tool. DMPP activates nicotinic receptors in autonomic ganglia but has little effect at the neuromuscular junction.


Giardia lamblia
Lamblia intestinalis
Giardia duodenalis
Giardia intestinalis

A species of parasitic EUKARYOTES that attaches itself to the intestinal mucosa and feeds on mucous secretions. The organism is roughly pear-shaped and motility is somewhat erratic, with a slow oscillation about the long axis.


An enzyme that catalyzes the transfer of UMP from UDPglucose to galactose 1-phosphate, forming UDPgalactose and glucose 1-phosphate. Deficiency in this enzyme is the major cause of GALACTOSEMIA. EC 2.7.7.12.


Heat-Shock Proteins 70
HSP70 Heat-Shock Proteins
Heat-Shock Protein 70
Heat Shock 70 kDa Protein

A class of MOLECULAR CHAPERONES found in both prokaryotes and in several compartments of eukaryotic cells. These proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures.


Decompression, Surgical
Surgical Decompression

A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)


Cysteine-Rich Protein 61
CYR61 Protein
IGFBP10 Protein
CCN1 Protein

A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.


ATM Protein
AT Mutated Protein
Ataxia Telangiectasia Mutated Proteins
A-T Protein

A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.


Adenoviruses, Avian
Avian Adenoviruses
Aviadenovirus

A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.


Latency Period, Psychology
Latency Period, Psychological
Latency Period (Psychology)

The period from about 5 to 7 years to adolescence when there is an apparent cessation of psychosexual development.


An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.


Western Dietary Pattern
Diet, Occidental
Western Diet
Meat-Sweet Diet
Diet, Western

A pattern of food consumption adopted mainly by the people of North America and Western Europe. It is mainly characterized by high intake of MEAT, processed grains, DIETARY SUGARS, DAIRY PRODUCTS, and DIETARY FATS.


Breakbone Fever
Dengue
Dengue Fever
Classical Dengue Fever
Classical Dengue
Break-Bone Fever

An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.


Deoxyribonucleic acid that makes up the genetic material of bacteria.


A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.


Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.


Aquaporin-CD
Aquaporin-2
Water Channel Of Collecting Duct
Aquaporin 2
AQP2 Protein

Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.


The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.


Vesication
Bleb
Bullae
Bulla
Bullous Lesion
Blister

Visible accumulations of fluid within or beneath the epidermis.


Zoster Sine Herpete
Zoster Sine Eruptione

HERPES ZOSTER but without eruption of vesicles. Patients exhibit the characteristic pain minus the skin rash, sometimes making diagnosis difficult.


Volunteer Workers
Volunteers
Untrained Personnel
Volunteerism
Voluntary Workers


Neuromyelitis Optica (NMO) Spectrum Disorders

A syndrome characterized by acute OPTIC NEURITIS; MYELITIS, TRANSVERSE; demyelinating and/or necrotizing lesions in the OPTIC NERVES and SPINAL CORD; and presence of specific autoantibodies to AQUAPORIN 4.


Antiinflammatory Agents
Antiinflammatories
Agents, Anti-Inflammatory
Agents, Antiinflammatory
Anti-Inflammatories
Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION.


Congenital Absence of the Abdominal Muscles

A syndrome characterized by abdominal wall musculature deficiency, cryptorchism, and urinary tract abnormalities. The syndrome derives its name from its characteristic distended abdomen with wrinkled skin.


Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc.


Cell Size Growth
Cell Enlargement
Cell Growth in Size

Growth processes that result in an increase in CELL SIZE.


Education of Persons With Impaired Vision

The teaching or training of those individuals with visual disability.


Beta-Globulins
Beta-Globulin
Beta(1)CA Globulin

Serum proteins with an electrophoretic mobility that falls between ALPHA-GLOBULINS and GAMMA-GLOBULINS.


TAT Secretion Systems
Twin-Arginine-Translocation System
Twin-Arginine-Translocation Systems
Twin-Arginine-Transport System

Protein translocase in BACTERIA or CHLOROPLASTS that exports or secretes folded proteins. In GRAM-NEGATIVE BACTERIA, twin-arginine translocase (TAT) is involved in the export of folded proteins to the PERIPLASM. In chloroplasts, TAT is involved in transporting folded proteins across the membranes of THYLAKOIDS.


Community Health Insurance
Mutual Health Insurance
Community-Based Health Insurance
Micro-Health Insurance
Community-Based Health Financing
Health Micro Insurance

Low-cost HEALTH INSURANCE in which community, cooperative, mutual, and/or self-help resources are pooled to mitigate health risks and cover health care services in full or in part.


A type I keratin found associated with KERATIN-8 in simple, or predominately single layered, internal epithelia.


Thyroid Carcinoma, Anaplastic
Thyroid Cancer, Anaplastic

An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.


Endamoeba histolytica
Entamoeba histolytica

A species of parasitic protozoa causing ENTAMOEBIASIS and amebic dysentery (DYSENTERY, AMEBIC). Characteristics include a single nucleus containing a small central karyosome and peripheral chromatin that is finely and regularly beaded.


Fructose-1,6-Bisphosphate Aldolase B Deficiency

An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.


Thiamine Pyrophosphatase
Thiamine Pyrophosphate Phosphohydrolase
TPPase

An enzyme that hydrolyzes thiamine pyrophosphate to thiamine monophosphate plus inorganic phosphate. EC 3.6.1.-.


Proteins that form the core of amyloid fibrils. For example, the core of amyloid A is formed from amyloid A protein, also known as serum amyloid A protein or SAA protein.


The science which utilizes psychologic principles to derive more effective means in dealing with practical problems.


A subclass of myosin involved in organelle transport and membrane targeting. It is abundantly found in nervous tissue and neurosecretory cells. The heavy chains of myosin V contain unusually long neck domains that are believed to aid in translocating molecules over large distances.


Meta-Analysis as Topic
Overviews, Clinical Trial
Data Pooling
Clinical Trial Overviews

A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.


Personality Disorders, Passive Aggressive

Passive Aggressive Personality Disorders

A personality disorder characterized by an indirect resistance to demands for adequate social and occupational performance; anger and opposition to authority and the expectations of others that is expressed covertly by obstructionism, procrastination, stubbornness, dawdling, forgetfulness, and intentional inefficiency. (Dorland, 27th ed)


Cold-blooded, air-breathing VERTEBRATES belonging to the class Reptilia, usually covered with external scales or bony plates.


Chondromalacia of Bronchi
Bronchomalacia

A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the BRONCHI. This results in a floppy bronchial wall making patency difficult to maintain. It is characterized by wheezing and difficult breathing.


Jaundice, Cholestatic
Jaundice, Mechanical
Jaundice, Obstructive

Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.


Hantavirus-Associated Respiratory Distress Syndrome

Acute respiratory illness in humans caused by the SIN NOMBRE VIRUS whose primary rodent reservoir is the deer mouse Peromyscus maniculatus. First identified in the southwestern United States, this syndrome is characterized most commonly by fever, myalgias, headache, cough, and rapid respiratory failure.


A placenta that fails to be expelled after BIRTH of the FETUS. A PLACENTA is retained when the UTERUS fails to contract after the delivery of its content, or when the placenta is abnormally attached to the MYOMETRIUM.


Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION.


Tennis Elbow
Epicondylitis, Lateral Humeral
Lateral Epicondylitis

A condition characterized by pain in or near the lateral humeral epicondyle or in the forearm extensor muscle mass as a result of unusual strain. It occurs due repetitive stresses on the elbow from activities such as tennis playing.


Gonadoliberin
Gn-RH
Gonadorelin Acetate
Dirigestran
Cystorelin
LHFSH Releasing Hormone
Factrel
LHFSHRH
LH-RH
Gonadotropin-Releasing Hormone
Kryptocur
LH-FSH Releasing Hormone
Gonadorelin
GnRH
LFRH
LH-Releasing Hormone
FSH-Releasing Hormone
Gonadorelin Hydrochloride
Luteinizing Hormone-Releasing Hormone
LHRH
Luliberin

A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.


Benzenemethanaminium Compounds
Benzyl Ammonium Compounds
Benzylammonium Compounds
Phenylmethyl Ammonium Compounds

QUATERNARY AMMONIUM COMPOUNDS based on BENZYLAMINES with the general formula phenyl-CN+R3.


Low Density Lipoprotein-Related Proteins

A family of proteins that share sequence similarity with the low density lipoprotein receptor (RECEPTORS, LDL).


Blood Transfusion, Autologous
Autotransfusion
Blood Transfusions, Autologous
Autologous Blood Transfusions
Autologous Blood Transfusion
Transfusion, Autologous Blood
Transfusions, Autologous Blood

Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)


An organothiophosphorus insecticide that has been used to control pig mange.


Minichromosome Maintenance 1 Protein
Transcription Factor MCM1
MCM1Transcription Factor

A sequence-specific DNA-binding protein that plays an essential role as a global regulator of yeast cell cycle control. It contains a 56 amino acid MADS-box domain within the N-terminal of the protein and is one of the four founder proteins that structurally define the superfamily of MADS DOMAIN PROTEINS.


Isoleucyl-tRNA Synthetase
Ile-tRNA Ligase
Isoleucine-tRNA Ligase
Isoleucyl T RNA Synthetase

An enzyme that activates isoleucine with its specific transfer RNA. EC 6.1.1.5.


Polysaccharides, Fungal
Fungal Polysaccharides

Cell wall components constituting a polysaccharide core found in fungi. They may act as antigens or structural substrates.


Gram-Negative Anaerobic Cocci
Gram Negative Anaerobic Cocci

A group of anaerobic coccoid bacteria that show up as pink (negative) when treated by the gram-staining method.


The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.


GRK5 Kinase
G-Protein-Coupled Receptor Kinase 5

A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions.


Leukemia Virus, Murine
Mouse Leukemia Viruses
Graffi Virus
Graffi's Chloroleukemic Strain
Murine Leukemia Viruses
Murine Leukemia Virus
Leukemia Viruses, Murine

Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.


Dental Pulp Test
Pulp Tests, Dental
Dental Pulp Tests
Pulp Test, Dental
Tests, Dental Pulp
Test, Dental Pulp

Investigations conducted on the physical health of teeth involving use of a tool that transmits hot or cold electric currents on a tooth's surface that can determine problems with that tooth based on reactions to the currents.


Krebs Cycle
Tricarboxylic Acid Cycle
Citric Acid Cycle

A series of oxidative reactions in the breakdown of acetyl units derived from GLUCOSE; FATTY ACIDS; or AMINO ACIDS by means of tricarboxylic acid intermediates. The end products are CARBON DIOXIDE, water, and energy in the form of phosphate bonds.


Cochlear Prosthesis
Auditory Prosthesis
Cochlear Implants
Implants, Cochlear

Electronic hearing devices typically used for patients with normal outer and middle ear function, but defective inner ear function. In the COCHLEA, the hair cells (HAIR CELLS, VESTIBULAR) may be absent or damaged but there are residual nerve fibers. The device electrically stimulates the COCHLEAR NERVE to create sound sensation.


Mitochondrial Dynamics
Mitochondrial Fission
Mitochondrial Fission and Fusion
Mitochondrial Fusion
Mitochondrial Fusion and Fission


Binding Sites, Antibody
Paratopes
Antibody Binding Sites

Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.


Classical Philology
Philology, Classical

The study of ancient Greek and Roman literature, including grammar, etymology, criticism, literary history, and language and linguistic history.


Apelin Receptor
Angiotensin Receptor-Like 1 Protein
APLNR
Apelin Receptors
Receptors, Apelin

G-protein coupled receptors for APELIN that function in a broad range of physiologic processes including blood pressure regulation and heart contractility. They also have an essential role in early embryo development for GASTRULATION and heart morphogenesis, and can also function as a CD4 co-receptor for HIV-1.


Physiologic period, characterized by endocrine, somatic, and psychic changes with the termination of ovarian function in the female. It may also accompany the normal diminution of sexual activity in the male.


Savings Accounts, Medical
Health Savings Accounts
Medical Savings Accounts
Accounts, Medical Savings

Tax-exempt trusts or custodial accounts established by individuals with financial institutions for saving money for future medical expenses.


An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)


Procedures, Cardiovascular Surgical
Surgical Procedures, Cardiovascular
Surgical Procedure, Cardiovascular
Cardiovascular Surgical Procedures
Cardiovascular Surgical Procedure
Procedure, Cardiovascular Surgical

Surgery performed on the heart or blood vessels.


Trabeculoplasty Trabeculectomy Goniotomy Trabeculotomy

Any surgical procedure for treatment of glaucoma by means of puncture or reshaping of the trabecular meshwork. It includes goniotomy, trabeculectomy, and laser perforation.


The observable, measurable, and often pathological activity of an organism that portrays its inability to overcome a habit resulting in an insatiable craving for a substance or for performing certain acts. The addictive behavior includes the emotional and physical overdependence on the object of habit in increasing amount or frequency.


Vaccines, Inactivated
Killed Vaccines
Vaccines, Killed

Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.


Hospital Physical Therapy Department
Physical Therapy Department, Hospital
Physical Therapy Departments, Hospital

Hospital department which is responsible for the administration and provision of diagnostic and medical rehabilitation services to restore or improve the functional capacity of the patient.


Ovarian Germline Stem Cells
Oogonial Stem Cells
Female Germline Stem Cells

Primordial germ cells found in embryonic OOGONIA and postnatal OVARIES.


Deuterium Exchange Measurement
Hydrogen-Deuterium Exchange Measurement

A research technique to measure solvent exposed regions of molecules that is used to provide insight about PROTEIN CONFORMATION.


Invertebrate Ganglia
Ganglia, Invertebrate
Ganglion, Invertebrate

Clusters of neuronal cell bodies in invertebrates. Invertebrate ganglia may also contain neuronal processes and non-neuronal supporting cells. Many invertebrate ganglia are favorable subjects for research because they have small numbers of functional neuronal types which can be identified from one animal to another.


The motion of fluids, especially noncompressible liquids, under the influence of internal and external forces.


Touch, Therapeutic
Reiki
Laying-on-of-Hands
Therapeutic Touch

Placing of the hands of the healer upon the person to be cured with the intent of spiritual energetic healing.


An enzyme that catalyzes the conversion of N-formyl-L-kynurenine and water to formate and L-kynurenine. It also acts on other aromatic formylamines. (Enzyme Nomenclature, 1992) EC 3.5.1.9.


vif Gene Products, Human Immunodeficiency Virus

vif Proteins, Human Immunodeficiency Virus

Proteins encoded by the VIF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.


Group A Streptogramin
Streptogramin Group A
Streptogramins, Group A

A structural subclass of streptogramins that includes molecules containing unsaturated macrocyclic lactones with approximate molecular weight of 500 KDa.


An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.


Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.


Hemolysis, Elevated Liver Enzymes, Lowered Platelets

A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.


A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.


Oligonucleotide Primers
DNA Primers
Oligodeoxyribonucleotide Primers

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.


Factor Eleven
Blood Coagulation Factor XI
Factor XI
Plasma Thromboplastin Antecedent
Coagulation Factor XI
Factor 11

Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.


Peri-Implant Fractures
Fractures, Periprosthetic
Periprosthetic Fractures

Fractures around joint replacement prosthetics or implants. They can occur intraoperatively or postoperatively.


Quitting Smoking
Stopping Smoking
Smoking Cessation
Giving Up Smoking


Indican
Indican Monosodium Salt
Indican Monopotassium Salt
Indoxyl Sulfate
1H-Indol-3-ol Hydrogen Sulfate Ester

A substance occurring in the urine of mammals and also in blood plasma as the normal metabolite of tryptophan. An increased urinary excretion of indican is seen in Hartnup disease from the bacterial degradation of unabsorbed tryptophan.


Cannabinoid Receptor CB1
Receptor, Cannabinoid, CB1
CB1 Receptor

A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.


Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).


A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.


The fraction of a blood sample, following CENTRIFUGATION, that is distinguished as a thin light-colored layer between the RED BLOOD CELLS, underneath it, and the PLASMA, above it. It is composed mostly of WHITE BLOOD CELLS and PLATELETS.


Paramphistomata Gastrodiscoides Paramphistomum Watsonius Paramphistomatidae Amphistomidae

A family of flukes of the class Trematoda found in the intestinal tract and liver of animals and man. Some of the genera are Homalagaster, Gastrodiscus, Paramphistomum, Watsonius, Nilocotyle, Gigantocotyle, Gastrothylax, Macropotrema, Ceylonocotyle, Zygocotyle, Cotylophoron, and Calicophoron.


Allosteric Regulation
Regulation, Allosteric

The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.


Diverticulum, Gastric
Gastric Diverticula
Stomach Diverticulum
Diverticula, Stomach
Diverticulum, Stomach

Saccular, outward protrusion of all or a portion of the wall of the STOMACH.


Cell Adhesion Molecules, Neural
NCAM
Cell Adhesion Molecule, Neural
Neural Cell Adhesion Molecules
Neural Cell Adhesion Molecule

Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (CD56 ANTIGEN); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)


Myocardial Contusions
Heart Contusions
Blunt Cardiac Injury
Myocardial Contusion
Contusio Cordis
Cardiac Contusion

Bruise to the heart muscle due to blunt thoracic trauma.


Pimaricin Myprozine Natamycin Tennecetin Pimafucin

Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.


Feraheme
Ferumoxytol
Ferriferrous Oxide
Ferrosoferric Oxide
Magnetite

Mineral form of iron oxide and a member of the spinel group, whose members are characterized by high hardness and high density.


A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)


Pharmacy Education
Education, Pharmacy
Education, Pharmaceutical
Education, Pharmaceutic

Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.


Ribosomal RNA Genes
Genes, rRNA
rRNA Genes

Genes, found in both prokaryotes and eukaryotes, which are transcribed to produce the RNA which is incorporated into RIBOSOMES. Prokaryotic rRNA genes are usually found in OPERONS dispersed throughout the GENOME, whereas eukaryotic rRNA genes are clustered, multicistronic transcriptional units.


Butoxamine
Butoxamine Hydrochloride
Butaxamine

A beta-2 selective adrenergic antagonist. It is used primarily in animal and tissue experiments to characterize BETA-2 ANDRENERGIC RECEPTORS.


RNase
Alkaline Ribonuclease
Acid Ribonuclease
Nucleases, RNA
Ribonucleases
Ribonuclease

Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.


Nyctiphanes Euphausiacea Euphausia Krill

An order of pelagic, shrimplike CRUSTACEA. Many consume ZOOPLANKTON and a few are predacious. Many antarctic species, such as Euphausia superba, constitute the chief food of other animals.


X-Linked Vacuolar Cardiomyopathy and Myopathy

Vacuolar Cardiomyopathy and Myopathy, X-linked

Lysosomal Glycogen Storage Disease with Normal Acid Maltase

Lysosomal Glycogen Storage Disease without Acid Maltase Deficiency

Glycogen Storage Disease Limited to the Heart

An X-linked dominant multisystem disorder resulting in cardiomyopathy, myopathy and INTELLECTUAL DISABILITY. It is caused by mutation in the gene encoding LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2.


A N-hydroxylated derivative of 2-ACETYLAMINOFLUORENE that has demonstrated carcinogenic action.


Clathrin Light Chains
Clathrin Light Chain


Anastomosis, Surgical
Surgical Anastomosis

Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.


A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.


A set of characteristics unique to the DNA of an individual organism or population obtained by analyzing small samples of biological material such as body tissues or fluids, used especially in the context of predicting susceptibility to a particular disease. For example, some populations have identifiable genetic profiles which put them at higher risk for cancer. Distinguish from GENETIC BACKGROUND and GENETIC VARIATION.


Radiation, Nonionizing
Non-Ionizing Radiation
Nonionizing Radiation

ELECTROMAGNETIC RADIATION or sonic radiation (SOUND WAVES) which does not produce IONS in matter through which it passes. The wavelengths of non-ionizing electromagentic radiation are generally longer than those of far ultraviolet radiation and range through the longest RADIO WAVES.


A course of food intake prescribed for patients, that limits the amount of foods with a high GLYCEMIC INDEX.


Mitogen-Activated Protein Kinase Kinase Kinase 3

A 70-kDa MAPK kinase kinase with specificity for MAP KINASE KINASE 5.


Ophthalmoplegia, Progressive External, With Ragged-Red Fibers

Chronic Progressive External Ophthalmoplegia with Myopathy

Ophthalmoplegia, Pigmentary Degeneration of Retina, and Cardiomyopathy

A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) with conduction block (HEART BLOCK), and RETINITIS PIGMENTOSA. Disease onset is in the first or second decade. Elevated CSF protein, sensorineural deafness, seizures, and pyramidal signs may also be present. Ragged-red fibers are found on muscle biopsy. (Adams et al., Principles of Neurology, 6th ed, p984)


Actinobacillus Infections
Infections, Actinobacillus

Infections with bacteria of the genus ACTINOBACILLUS.


Blastocystis Infections
Infections, Blastocystis
Blastocystis hominis Infections

Infections with organisms of the genus BLASTOCYSTIS. The species B. hominis is responsible for most infections. Parasitologic surveys have generally found small numbers of this species in human stools, but higher positivity rates and organism numbers in AIDS patients and other immunosuppressed patients (IMMUNOCOMPROMISED HOST). Symptoms include ABDOMINAL PAIN; DIARRHEA; CONSTIPATION; VOMITING; and FATIGUE.


HLA-DRB5
HLA-DRB5 Antigen
HLA-DRB5 Chains
HLA DRB5

A subtype of HLA-DRB beta chains that is associated with the HLA-DR51 serological subtype.


Solute Carrier-Family 25 (Mitochondrial Carrier - Adenine Nucleotide Translocator), Member 5

Adenine Nucleotide Translocator, Fibroblast Isoform

A subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.


Viral Skin Diseases
Skin Diseases, Viral


Silent Mating Type Information Regulation 2 Homolog 2

A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.


Allergen Bronchial Provocation Tests
Allergen Challenge, Endobronchial
Antigen Bronchial Provocation Tests
Bronchial Challenge Tests
Provocation Tests, Bronchial
Bronchial Allergen Challenge
Bronchial Provocation Tests
Inhalation Provocation Tests
Endobronchial Challenge Tests

Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.


Synthetic Prostaglandins F
Prostaglandins F, Synthetic
Prostaglandin F Analogues
PGF Synthetic
Prostaglandin F Analogs

Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.


Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.


30S Ribosome Subunits, Archaeal
Small Ribosomal Subunits, Archaeal
Ribosomal Subunits, 30S, Archaeal
Ribosome Subunits, Small, Archaeal
30S Ribosomal Subunits, Archaeal
Small Ribosome Subunits, Archaeal
Ribosome Subunits, 30S, Archaeal
Ribosomal Subunits, Small, Archaeal
Archaeal Small Ribosomal Subunits
Archaeal Small Ribosome Subunits

The small subunit of archaeal RIBOSOMES. It is composed of the 16S RIBOSOMAL RNA and about 28 different RIBOSOMAL PROTEINS.


Breast Cancer Type 1 Susceptibility Protein

The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)


Bio-Monitoring
Monitoring, Biological
Biomonitoring
Biologic Monitoring
Biological Monitoring

Monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the bodies of living organisms, by DIAGNOSTIC IMAGING or by analyzing BLOOD; URINE; BREAST MILK; SALIVA, etc.


Apolipoproteins D
Apolipoprotein D
Apo D
ApoD Protein

A glycoprotein component of HIGH-DENSITY LIPOPROTEINS that transports small hydrophobic ligands including CHOLESTEROL and STEROLS. It occurs in the macromolecular complex with LECITHIN CHOLESTEROL ACYLTRANSFERASE. Apo D is expressed in and secreted from a variety of tissues such as liver, placenta, brain tissue and others.


A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.


Fasciculation, Skeletal Muscle
Fasciculation
Fasciculation, Tongue
Fasciculation, Muscular
Fasciculation, Benign

Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)


An enzyme that catalyzes the degradation of GLYCOGEN in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. This enzyme exists in two forms: an active phosphorylated form ( PHOSPHORYLASE A) and an inactive un-phosphorylated form (PHOSPHORYLASE B). Both a and b forms of phosphorylase exist as homodimers. In mammals, the major isozymes of glycogen phosphorylase are found in muscle, liver and brain tissue.


Lymphatic Stomata
Peritoneal Stomata
Diaphragmatic Stomata
Diaphragmatic Stomas
Peritoneal Stomas
Stomata, Peritoneal
Lymphatic Stomas

Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. Peritoneal stomata constitute the principal pathways for the drainage of intraperitoneal contents from the PERITONEAL CAVITY to the LYMPHATIC SYSTEM.


Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)


Benign Hyperglobulinemic Purpura of Waldenström

Hypergammaglobulinemic Purpura of Waldenstrom

Purplish or brownish red discoloration of the skin associated with increase in circulating polyclonal globulins, usually GAMMA-GLOBULINS. This syndrome often occurs on the legs of women aged 20 to 40 years.


Respiratory Syncytial Virus, Human
Human respiratory syncytial virus

The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.


LAK Cells
Lymphokine-Activated Killer Cells
Killer Cells, Lymphokine-Activated

Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.


Gonorrhea
Neisseria gonorrhoeae Infection

Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.


Dermatitis, Contact, Phototoxic
Dermatitis, Phototoxic
Phototoxic Dermatitis
Phototoxic Contact Dermatitis
Phototoxicity

A nonimmunologic, chemically induced type of photosensitivity producing a sometimes vesiculating dermatitis. It results in hyperpigmentation and desquamation of the light-exposed areas of the skin.


Tax on the net income of an individual, organization, or business.


This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanidinoacetate to CREATINE.


Mesenchymal Stem Cell Transplantation
Transplantation, Mesenchymal Stem Cell
Stem Cell Transplantation, Mesenchymal

Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).


Multi-Vesicular Bodies
Endosomal Carrier Vesicles
Multivesicular Bodies

Endosomes containing intraluminal vesicles which are formed by the inward budding of the endosome membrane. Multivesicular bodies (MVBs) may fuse with other organelles such as LYSOSOMES or fuse back with the PLASMA MEMBRANE releasing their contents by EXOCYTOSIS. The MVB intraluminal vesicles released into the extracellular environment are known as EXOSOMES.


5S RNA Gene Transcription Factor
5S Gene-Specific Transcription Factor
TFIIIA
Transcription Factor TFIIIA
Transcription Factor IIIA
GTF3A Protein

One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.


Specific Language Disorder
Specific Language Impairment

Language disorder that delays the mastery of oral language skills or  in children who have no hearing loss or other developmental delays.


Microscopy, Ultraviolet
Ultraviolet Microscopy

Microscopy in which the image is formed by ultraviolet radiation and is displayed and recorded by means of photographic film.


Nucleus Tegmentalis Pedunculopontinus
Pedunculopontine Tegmental Nucleus

Dense collection of cells in the caudal pontomesencephalic tegmentum known to play a role in the functional organization of the BASAL GANGLIA and in the modulation of the thalamocortical neuronal system.


Paraoxonase
OPA Anhydrase
Paraoxonase-1
Organophosphorus Acid Anhydrolase
Organophosphorus Acid Hydrolase
Aryl-dialkyl Phosphatase
Arylalkylphosphatase
Homocysteine Thiolactone Hydrolase
Organophosphorus Acid Anhydrase
Aryldialkylphosphatase
Paraoxonase-2
OPH Enzyme
Organophosphorus Hydrolase

An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).


Faculty Practice, Nursing
Nursing Faculty Practice
Practice, Nursing Faculty

Clinical practice by members of the nursing faculty in order to maintain a balance in their nursing activities--clinical, education, and research.


Genetic Polymorphisms
Polymorphism (Genetics)
Polymorphism, Genetic
Genetic Polymorphism

The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.