Index of Orthodontic Treatment Need
Index of Orthodontic Treatment Needs
Index for Need of Orthodontic Treatment

A dental health survey developed to evaluate a patient's orthodontic treatment need and priority for orthodontic care. The index is based on an assessment of degree of MALOCCLUSION and the potential aesthetic and dental health benefit of the treatment under consideration.


Protein Tyrosine Phosphatase, Non-Receptor Type 11

A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutations in the gene for protein tyrosine phosphatase, non-receptor type 11 are associated with NOONAN SYNDROME.


CD34 Antigens
CD34 Antigen
Antigens, CD34

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.


Alexia, Pure
Visual Verbal Agnosia
Pure Word Blindness
Pure Alexia
Alexia Syndrome Without Agraphia
Alexia Without Agraphia
Pure Alexia Without Agraphia

Loss of the power to comprehend written materials despite preservation of the ability to write (i.e., alexia without agraphia). This condition is generally attributed to lesions that "disconnect" the visual cortex of the non-dominant hemisphere from language centers in the dominant hemisphere. This may occur when a dominant visual cortex injury is combined with underlying white matter lesions that involve crossing fibers from the occipital lobe of the opposite hemisphere. (From Adams et al., Principles of Neurology, 6th ed, p483)


A multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ. It is involved in a variety of biological events including interactions with galactose-containing glycoconjugates, cell proliferation, CELL DIFFERENTIATION, and APOPTOSIS.


A genus of protozoa found in reptiles, birds, and mammals, including humans. This heteroxenous parasite produces muscle cysts in intermediate hosts such as domestic herbivores (cattle, sheep, pigs) and rodents. Final hosts are predators such as dogs, cats, and man.


The use of dancing for therapeutic purposes.


Period, Psychological Refractory
Periods, Psychological Refractory
Psychological Refractory Periods
Psychological Refractory Period
Refractory Period, Psychological
Refractory Periods, Psychological
Refractory Period, Psychologic

A delayed response interval occurring when two stimuli are presented in close succession.


Audits, Dental
Audit, Dental
Dental Audit
Dental Audits

A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of dental care.


Trans-Cinnamate 4-Monooxygenase CYP73
Cinnamate 4-Hydroxylase
Trans-Cinnamic Acid 4-Hydroxylase
Trans-Cinnamate 4-Monooxygenase

A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate.


Serodiagnosis, HIV
Serology, AIDS
Serology, HTLV-III
HIV Serodiagnosis
AIDS Serodiagnosis
Serodiagnosis, HTLV-III
Serodiagnosis, AIDS
AIDS Serology
HTLV-III Serology
HTLV-III Serodiagnosis

Immunologic tests for identification of HIV (HTLV-III/LAV) antibodies. They include assays for HIV SEROPOSITIVITY and HIV SERONEGATIVITY that have been developed for screening persons carrying the viral antibody from patients with overt symptoms of AIDS or AIDS-RELATED COMPLEX.


C4b Complement
Complement 4b
Complement Component 4b
Complement C4b

The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).


Lipid Metabolism, Inborn Error
Lipid Metabolism, Inborn Errors

Errors in the metabolism of LIPIDS resulting from inborn genetic MUTATIONS that are heritable.


Vertigo, Benign Paroxysmal Positional
Benign Recurrent Vertigo
Vertigo, Benign Recurrent
Vestibulopathy, Familial
Familial Vestibulopathy
Familial Benign Recurrent Vertigo
Benign Paroxysmal Positional Vertigo

Idiopathic recurrent VERTIGO associated with POSITIONAL NYSTAGMUS. It is associated with a vestibular loss without other neurological or auditory signs. Unlike in LABYRINTHITIS and VESTIBULAR NEURONITIS, inflammation in the ear is not observed.


Sin3-Histone Deacetylase (HDAC) Corepressor Complex

Sin3 Histone Deacetylase and Corepressor Complex

A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE residues of NUCLEOSOMES.


Cupressales Pinales Taxales Araucariales

Order of Conifers of the class Pinopsida, subdivision Spermatophytina, and division Tracheophyta. The distinguishing attribute of the Pinales is the reproductive structure known as a cone.


Benzoylarginine Nitroanilide, Monosodium Salt, Monohydrochloride

A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product.


Transcription Start Site
Transcription Initiation Site

The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.


The shortest duration of an electrical stimulus where the threshold amplitude is twice the rheobase - the minimum required for eliciting an ACTION POTENTIAL at any time period. It is a measure of the excitability of nerve or muscle tissue, and is characteristic of types and/or condition of the nerve or muscle cells in the tissue.


Transesophageal Echocardiography
Echocardiography, Transesophageal

Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.


Polyps-and-Spots Syndrome
Periorificial Lentiginosis Syndrome
Polyposis, Hamartomatous Intestinal
Lentiginosis, Perioral
Peutz-Jeghers Syndrome
Peutz-Jeghers Polyposis
Peutz-Jegher's Syndrome

A hereditary disease caused by autosomal dominant mutations involving CHROMOSOME 19. It is characterized by the presence of INTESTINAL POLYPS, consistently in the JEJUNUM, and mucocutaneous pigmentation with MELANIN spots of the lips, buccal MUCOSA, and digits.


Subdural Empyema
Abscess, Intracranial, Subdural
Empyema, Subdural

An intracranial or rarely intraspinal suppurative process invading the space between the inner surface of the DURA MATER and the outer surface of the ARACHNOID.


Monocyte Chemotactic Proteins
Monocyte Chemoattractant Proteins

Chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.


ALDH2 Protein
Aldehyde Dehydrogenase, Mitochondrial

An aldehyde dehydrogenase expressed in the mitochondrial matrix that is essential for the metabolism of ETHANOL.


Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs.


Peptidylarginine Deiminase Type VI
Peptidylarginine Deiminase Type 6
Peptidyl Arginine Deiminase Type 6
Protein Arginine Deiminase Type VI
Peptidyl Arginine Deiminase Type VI
Protein Arginine Deiminase Type 6
Protein-Arginine Deiminase Type 6
Protein Arginine Deiminase 6
Protein-Arginine Deiminase Type VI
Peptidylarginine Deiminase VI
PADI6 Protein

A peptidylarginine deiminase isoenzyme mainly expressed in egg and embryo tissues. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner.


Occult Spina Bifida
Spina Bifida Occulta
Spinal Bifida, Closed
Dermal Sinus

A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34)


A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.


Membrane Attack Complex Inhibition Factor

Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)


The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)


Surgically-Created Structures
Structures, Surgically-Created
Structure, Surgically-Created
Surgically-Created Structure

Organs or parts of organs surgically formed from nearby tissue to function as substitutes for diseased or surgically removed tissue.


Pyridoxinephosphate Oxidase
Pyridoxaminephosphate Oxidase
Pyridoxine-5-Phosphate Oxidase

An enzyme catalyzing the deamination of pyridoxaminephosphate to pyridoxal phosphate. It is a flavoprotein that also oxidizes pyridoxine-5-phosphate and pyridoxine. EC 1.4.3.5.


A genus of the subfamily ALOUATTINAE, family ATELIDAE, inhabiting the forests of Central and South America. Howlers travel in groups and define their territories by howling accompanied by vigorously shaking and breaking branches.


A macular lesion on the side of the FACE, involving the CONJUNCTIVA and EYELIDS, as well as the adjacent facial skin, SCLERA; OCULOMOTOR MUSCLES; and PERIOSTEUM. Histological features vary from those of a MONGOLIAN SPOT to those of a BLUE NEVUS.


Dibenzoyl Peroxide
Benzoyl Superoxide
Diphenylglyoxal Superoxide
PanOxyl
Benzoyl Peroxide

A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.


Inflammation of the inner ear (LABYRINTH).


Arylsulfate Sulfohydrolases
Pseudo Arylsulfatase A
Arylsulfatases
Arylsulphatases

Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.1.


A family of calcium-binding alpha-globulins that are synthesized in the LIVER and play an essential role in maintaining the solubility of CALCIUM in the BLOOD. In addition the fetuins contain aminoterminal cystatin domains and are classified as type 3 cystatins.


Bradykinin B2 Receptors
Bradykinin B2 Receptor
Bradykinin Type 2 Receptor
Receptor, Bradykinin Type 2
Receptor, Bradykinin B2

A constitutively expressed subtype of bradykinin receptor that may play a role in the acute phase of the inflammatory and pain response. It has high specificity for intact forms of BRADYKININ and KALLIDIN. The receptor is coupled to G-PROTEIN, GQ-G11 ALPHA FAMILY and G-PROTEIN, GI-GO ALPHA FAMILY signaling proteins.


Influenzavirus D
Thogoto virus
Dhori virus
Influenza Viruses Type D
Thogoto-Like Viruses
Thogotovirus
Orthomyxoviruses Type D
Influenza D Virus

A genus of the family ORTHOMYXOVIRIDAE comprising tick-borne viruses occasionally infecting humans. Dhori and Thogoto viruses were formerly thought to be members of BUNYAVIRIDAE. Thogoto virus is the type species.


Triiodothyronine, Reverse
3,3,5 Triiodothyronine
3,3,5-Triiodothyronine
3,3',5'-Triiodothyronine
Reverse Triiodothyronine
Reverse T3 Thyroid hormone

A metabolite of THYROXINE, formed by the peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus.


An enzyme that catalyzes the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate. It takes part in the L-SERINE biosynthesis pathway.


Tax-Responsive Element-Binding Protein 5

A basic leucine zipper transcription factor that regulates expression of MHC CLASS II GENES through its binding to a conserved X-box DNA sequence in the promoter region. It regulates the expression of genes involved in the UNFOLDED PROTEIN RESPONSE.


Microbiology, Industrial
Industrial Microbiology

The study, utilization, and manipulation of those microorganisms capable of economically producing desirable substances or changes in substances, and the control of undesirable microorganisms.


Olfactory Nerve Diseases
Cranial Nerve I Diseases
Cranial Nerve I Disorders
First Cranial Nerve Diseases

Diseases of the first cranial (olfactory) nerve, which usually feature anosmia or other alterations in the sense of smell and taste. Anosmia may be associated with NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; CRANIOCEREBRAL TRAUMA; inherited conditions; toxins; METABOLIC DISEASES; tobacco abuse; and other conditions. (Adams et al., Principles of Neurology, 6th ed, pp229-31)


Two-Dimensional Difference Gel Electrophoresis

2-Dimensional Difference Gel Electrophoresis

Methods of comparing two or more samples on the same two-dimensional gel electrophoresis gel.


Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.


Phosphodiesterase 4 Inhibitors
PDE-4 Inhibitors
PDE4 Inhibitors
Phosphodiesterase Type 4 Inhibitors

Compounds that specifically inhibit PHOSPHODIESTERASE 4.


Orthodontic Retainers
Retainers, Orthodontic

Orthodontic appliances, fixed or removable, used to maintain teeth in corrected positions during the period of functional adaptation following corrective treatment. These appliances are also used to maintain the positions of the teeth and jaws gained by orthodontic procedures. (From Zwemer, Boucher's Clinical Dental Terminology, 4th ed, p263)


PGE Receptor, EP2 Subtype
Prostanoid Receptor EP2
Prostaglandin E Receptor 2
Receptors, Prostaglandin E, EP2 Subtype

A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLYL CYCLASES.


Exophoria
Exodeviation
Alternating Exotropia
Divergent Strabismus
Strabismus, Divergent
Exotropia
Monocular Exotropia
Primary Exotropia
Secondary Exotropia

A form of ocular misalignment where the visual axes diverge inappropriately. For example, medial rectus muscle weakness may produce this condition as the affected eye will deviate laterally upon attempted forward gaze. An exotropia occurs due to the relatively unopposed force exerted on the eye by the lateral rectus muscle, which pulls the eye in an outward direction.


Triton X-305
Octylphenoxy Polyethoxyethanol
Triton X-45
Triton X-100
Octoxinols
Octoxinol
Octoxynols
Octoxynol
Octylphenoxypolyethoxyethanols
Octoxynol-9

Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Octoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide.


Electron Microscopy
Microscopy, Electron

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.


Drug Contraindications
Contraindications, Drug

A condition or factor associated with a recipient that makes the use of a specific drug improper or inadvisable.


Faecalibacterium prausnitzii
Fusobacterium prausnitzii

A species of FAECALIBACTERIUM, previously classified in the FUSOBACTERIUM genus, that is a major constituent of the GUT MICROBIOTA in healthy humans. It has anti-inflammatory activity and reduced numbers of this species occur in patients with INFLAMMATORY BOWEL DISEASES such as CROHN DISEASE.


Benign hypertrophy that projects outward from the surface of bone, often containing a cartilaginous component.


Blind Spot
Optic Disk
Optic Nerve Head
Optic Papilla
Optic Disc

The portion of the optic nerve seen in the fundus with the ophthalmoscope. It is formed by the meeting of all the retinal ganglion cell axons as they enter the optic nerve.


Healthcare Common Procedure Coding System

Uniform method for health care providers and medical suppliers to report professional services, procedures, and supplies. It consists of alphanumeric codes and modifiers for the use of all public and private health insurers. It is developed by the Centers for Medicare and Medicaid Services.


Bovine Viral Diarrhea Viruses
Diarrhea Viruses, Bovine Viral
Diarrhea Virus, Bovine Viral
Bovine Diarrhea Virus
Bovine Pestivirus

A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes.


A leukomaine (animal alkaloid) formed in brain and liver from dopamine and L-dopa; it may be implicated in psychiatric problems.


Transforming Growth Factor
Transforming Growth Factors

Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.


Vasopressin, Isoleucyl
(8-Arginine)Oxytocin
Arginine Vasotocin
3-Isoleucyl Vasopressin
Vasopressin, Non-Mammalian
Arginine Oxytocin
Vasotocin
Argiprestocine
Argiprestocin

A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.


A progesterone that has been used in ESTRUS SYNCHRONIZATION and has been evaluated as an injectable contraceptive in combination with estradiol enanthate. It is also applied topically as an anti-inflammatory and in the treatment of ACNE.


A plant genus of the family BETULACEAE. The tree has smooth, resinous, varicolored or white bark, marked by horizontal pores (lenticels), which usually peels horizontally in thin sheets.


Muscarinic Receptors M4
Receptor, Muscarinic M4
Muscarinic Receptor M4
Receptors, Muscarinic M4

A specific subtype of muscarinic receptor found in the CORPUS STRIATUM and the LUNG. It has similar receptor binding specificities to MUSCARINIC RECEPTOR M1 and MUSCARINIC RECEPTOR M2.


Infantile Respiratory Distress Syndrome
Respiratory Distress Syndrome, Newborn
Neonatal Respiratory Distress Syndrome
Respiratory Distress Syndrome, Infant

A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.


Talin
Platelet Protein p235
Band 2 Protein

A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.


It was established in 1961 and made an independent agency in 1981. Its mission is to help the people of interested countries in meeting their need for trained men and women, and to help promote better mutual understanding between Americans and citizens of other countries. (United States Government Manual, 2006-2007, pg497)


The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.


Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.


Infection of the striated muscle of mammals by parasites of the genus SARCOCYSTIS. Disease symptoms such as vomiting, diarrhea, muscle weakness, and paralysis are produced by sarcocystin, a toxin produced by the organism.


Cell Membrane Projections
Cell Surface Protrusions
Cell Membrane Protrusions
Cell Surface Extensions
Cell Membrane Extensions
Cellular Protrusions
Cell Surface Projections

Specialized structures of the cell that extend the cell membrane and project out from the cell surface.


Mentally Ill Persons
Mentally Ill
Mental Patients

Persons with psychiatric illnesses or diseases, particularly psychotic and severe mood disorders.


Blockers, Endothelin A Receptor
Endothelin A Receptor Antagonists
Endothelin A Receptor Blockers
Antagonists, Endothelin A Receptor
Endothelin Type A Receptor Antagonists

Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN A RECECPTORS.


Steroids that contain a ketone group at position 17.


p70 S6 Kinase
Ribosomal Protein S6 Kinases, 70-kDa
p70s6k

A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.


Diplococcus pneumoniae
Pneumococcus
Streptococcus pneumoniae

A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.


Diagnosis-Related Group Outliers
Outliers, DRG
DRG Outliers
Diagnostic-Related Group Outliers
Outliers, Diagnosis-Related Group

In health care reimbursement, especially in the prospective payment system, those patients who require an unusually long hospital stay or whose stay generates unusually high costs.


Esophageal Motility Disorders
Nutcracker Esophagus
Esophageal Dysmotility

Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).


Contractile tissue that produces movement in animals.


Pneumonia, Ventilator-Associated
Ventilator-Associated Pneumonia

Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by bacterial CROSS INFECTION in hospitals.


S100 Calcium-Binding Protein A4
S100A4 Protein
Metastasin Protein
Fibroblast-Specific Protein 1
Placental Calcium-Binding Protein
Calvasculin Protein

An S100 protein characterized by four helix bundles that form N- and C-terminal EF HAND MOTIFS. It functions as a homodimer and interacts with both intracellular and extracellular signaling proteins. Aberrant S100A4 activity is associated with NEOPLASM METASTASIS; FIBROSIS; and RHEUMATOID ARTHRITIS.


Surgical Hemostasis
Hemostasis, Surgical

Control of bleeding during or after surgery.


Exomphalos
Omphalocele
Umbilical Hernia
Hernia, Umbilical

A congenital defect with major fissure in the ABDOMINAL WALL at the UMBILICUS resulting in the extrusion of VISCERA through the UMBILICUS. Unlike GASTROSCHISIS, omphalocele is covered with PERITONEUM but without overlying SKIN.


A FLAVOPROTEIN, this enzyme catalyzes the oxidation of SARCOSINE to GLYCINE; FORMALDEHYDE; and HYDROGEN PEROXIDE (H2O2).


Persons who work in a mine to extract ore or MINERALS from the earth.


An approximately 40 amino acid protein domain that occurs in a variety of unrelated proteins and may be repeated up to four times in some proteins. It is characterized by two TRYPTOPHAN residues (WW) about 20 amino acids apart and folds into a stable triple-stranded BETA-SHEET. It binds PROLINE-RICH PROTEIN DOMAINS and PHOSPHOSERINE or PHOSPHOTHREONINE-containing protein domains that occur in many signal-transducing and cytoskeletal proteins such as DYSTROPHIN.


A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.


Receptors, Retinoic Acid
Retinoic Acid-Binding Proteins
Retinoic Acid Receptors
Retinoic Acid Receptor

Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.


Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.


The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.


Enzymes that catalyze the transfer of N-acetylglucosamine from a nucleoside diphosphate N-acetylglucosamine to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.


Freons
Freon
Chlorofluorocarbon Derivatives
Chlorofluorocarbons

A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning fluids, solvents, and as fire extinguishing agents. They have been shown to cause stratospheric ozone depletion and have been banned for many uses.


Proton Pump
H+ Pump
Proton Pumps
H(+) Pump

Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.


Uptake of substances by tissues of the eye.


CCK-B Receptors
Cholecystokinin B Receptor
CKK-2 Receptor
CCK2 Receptor
Receptor, Cholecystokinin B
Receptor, CCK-B
Receptors, Gastrin
Cholecystokinin-2 Receptor
CCK-B Receptor
Gastrin Receptor

A subtype of cholecystokinin receptor found primarily in the CENTRAL NERVOUS SYSTEM and the GASTRIC MUCOSA. It may play a role as a neuromodulator of dopaminergic neurotransmission the regulation of GASTRIC ACID secretion from GASTRIC PARIETAL CELLS.


Nucleosomal Binding Protein 2, High Mobility Group

An evolutionarily conserved 9-KDa nuclear protein that binds NUCLEOSOMES and may be involved in the process of CHROMATIN unfolding.


Psychotic Disorders
Schizoaffective Disorder
Schizophreniform Disorders
Psychosis, Brief Reactive
Psychosis
Psychoses

Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)


Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.


Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.


Tumor Burden
Tumor Volume
Tumor Load
Tumor Weight

The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.


C3b Receptors
CD 35 Antigens
Complement 3b Receptors
CD35 Antigen
Receptors, C3b
Antigens, CD35
CD35 Antigens
Receptors, Complement 3b
Receptors, CR1
Complement 3b Receptor
CR1 Receptors

Molecular sites on or in some B-lymphocytes and macrophages that recognize and combine with COMPLEMENT C3B. The primary structure of these receptors reveal that they contain transmembrane and cytoplasmic domains, with their extracellular portion composed entirely of thirty short consensus repeats each having 60 to 70 amino acids.


DEAD Box Protein DP 103
Gemin3 Protein
DDX20 Protein
Gemin-3 Protein
DEAD Box Protein 20

A multifunctional protein that is both a DEAD-box RNA helicase and a component of the SMN protein complex.


Liriope Plant
Liriope spicatum
Lilyturf
Liriope muscari

A plant genus of the family Asparagaceae. Members contain ruscogenin. Do not confuse with the Liriope jellyfish (CNIDARIA).


A nevus in which nests of melanocytes are found in the dermis, but not at the epidermal-dermal junction. Benign pigmented nevi in adults are most commonly intradermal. (Stedman, 25th ed)


The formation of soft patches on the mucous membrane of a hollow organ, such as the urogenital tract or digestive tract.


Receptors, Interferon
Interferon Receptor
Interferon Receptors

Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. Interferons exert their pleiotropic effects through two different receptors. alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system.


Pregnancy-Associated Endometrial Alpha-2 Globulin

A lipocalin that is the most abundant protein synthesized and secreted by the ENDOMETRIUM from mid-LUTEAL PHASE of the MENSTRUAL CYCLE through early PREGNANCY.


Dental High-Speed Techniques
Dental Technic, High-Speed
Technic, Dental High-Speed
Techniques, Dental High-Speed
Technics, High-Speed Dental
Dental High-Speed Technique
High-Speed Techniques, Dental
High-Speed Dental Technics
Techniques, High-Speed Dental
High-Speed Technic, Dental
Technique, Dental High-Speed
Technic, High-Speed Dental
Dental Technics, High-Speed
Dental Technique, High-Speed
High-Speed Technique, Dental
Dental High-Speed Technic
High-Speed Technics, Dental
Technique, High-Speed Dental
High-Speed Dental Technic
High-Speed Dental Technique
High-Speed Dental Techniques
Dental Techniques, High-Speed
Dental High-Speed Technics
Technics, Dental High-Speed

Dental methods involving the use of DENTAL HIGH-SPEED EQUIPMENT.


Signal Transduction, Light
Light Signal Transduction
Phototransduction

The conversion of absorbed light energy into molecular signals.


Repetitive Strain Injury
Repetitive Stress Injury
Trauma Disorders, Cumulative
Repetition Strain Injury
Strain Injury, Repetition
Overuse Syndrome
Overuse Injury
Injury, Repetition Strain
Cumulative Trauma Disorders
Repetitive Motion Disorders

Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.


NG-Nitroarginine Methyl Ester, D-Orn-Isomer

NG-Nitroarginine Methyl Ester, L-Orn-Isomer, Monohydrochloride

A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.


Basilar Papilla
Spiral Organ
Organ of Corti
Corti's Organ

The equivalent of the organ of Corti in non-mammalian tetrapods although its shape has evolved into a more extended structure in mammals.


Oct-2 Transcription Factor
Octamer Transcription Factor-2
Transcription Factor Oct-2

An octamer transcription factor expressed primarily in B-LYMPHOCYTES and the developing CENTRAL NERVOUS SYSTEM that regulates GENETIC TRANSCRIPTION of IMMUNOGLOBULIN GENES.


Forced Expiratory Flow 200-1200
Maximal Expiratory Flow Rate
Forced Expiratory Flow 0.2-1.2
Flow Rate, Maximal Expiratory
MEFR

The airflow rate measured during the first liter expired after the first 200 ml have been exhausted during a FORCED VITAL CAPACITY determination. Common abbreviations are MEFR, FEF 200-1200, and FEF 0.2-1.2.


Receptors, Interleukin-8B
CDw128b Antigens
Interleukin-8 Receptor Type B
CXC Chemokine Receptor 2
Interleukin-8B Receptor
Interleukin-8 Receptors Type B
Receptors, CXCR2
Interleukin-8B Receptors
CXCR2 Receptors
CXCR2 Protein
Interleukin-8 Receptors B
Antigens, CDw128b

High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.


Diamfenetide
Diamphenethide
Acemidophen
Di-(2-(4-acetamidophenoxy)ethyl) Ether
Coriban

Anthelmintic. It has been shown to be useful in fasciola infections in sheep.


LET
Linear Energy Transfer
Energy Transfer, Linear

Rate of energy dissipation along the path of charged particles. In radiobiology and health physics, exposure is measured in kiloelectron volts per micrometer of tissue (keV/micrometer T).


Cardiovascular Rehabilitation
Cardiac Rehabilitation

Restoration of functions to the maximum degree possible in a person or persons suffering from a CARDIOVASCULAR DISEASE. It also includes cardiac conditioning and SECONDARY PREVENTION in patients with elevated cardiovascular risk profile.


Enzymes that catalyze the rearrangement of geometry about double bonds. EC 5.2.


Tumor Antibodies
Antibodies, Neoplasm
Neoplasm Antibodies

Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.


Insurance Design
Value-Based Insurance Design
Value-Based Health Insurance

Approach to improve the quality of care by selectively encouraging or discouraging the use of specific health care services, based on their potential benefit to patients' health, relative to their cost. One element is lowering beneficiary cost sharing or out-of-pocket spending to increase medication adherence.


Alicyclic Hydrocarbons
Hydrocarbons, Alicyclic

Organic compounds composed exclusively of carbon and hydrogen. Three or more carbon atoms are arranged in a cyclic structure and they possess aliphatic properties.


JME (Juvenile Myoclonic Epilepsy)
Myoclonic Epilepsy, Juvenile, 1
Petit Mal, Impulsive, Janz
Epilepsy, Myoclonic, Juvenile
Juvenile Myoclonic Epilepsy of Janz
Myoclonic Epilepsy, Adolescent
Juvenile Myoclonic Epilepsy
Janz Juvenile Myoclonic Epilepsy
Petit Mal, Impulsive
Janz Impulsive Petit Mal
Adolescent Myoclonic Epilepsy
Myoclonic Epilepsy, Juvenile
Impulsive Petit Mal, Janz
Janz Syndrome
Impulsive Petit Mal Epilepsy
Epilepsy, Myoclonic Juvenile

A disorder characterized by the onset of myoclonus in adolescence, a marked increase in the incidence of absence seizures (see EPILEPSY, ABSENCE), and generalized major motor seizures (see EPILEPSY, TONIC-CLONIC). The myoclonic episodes tend to occur shortly after awakening. Seizures tend to be aggravated by sleep deprivation and alcohol consumption. Hereditary and sporadic forms have been identified. (From Adams et al., Principles of Neurology, 6th ed, p323)


Opioid Antagonists
Competitive Opioid Antagonists
Opioid Reversal Agents
Narcotic Antagonists
Opioid Receptor Antagonists

Agents inhibiting the effect of narcotics on the central nervous system.


Fibromatosis Hyalinica Multiplex Juvenilis

Autosomal recessive disorder characterized by HYALINE deposition in the skin, bone, gastrointestinal tract, muscles and glands; multiple subcutaneous skin nodules; GINGIVAL HYPERTROPHY; and joint CONTRACTURES. Mutations in the capillary morphogenesis protein-2 are associated with the disorder.


The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.


Myophosphorylase
Glycogen Phosphorylase a, Muscle Form
Glycogen Phosphorylase b, Muscle Form
Glycogen Phosphorylase, Muscle Form
Myophosphorylase a and b

An isoenzyme of GLYCOGEN PHOSPHORYLASE that catalyzes the degradation of GLYCOGEN in muscle. Mutation of the gene coding this enzyme is the cause of McArdle disease (GLYCOGEN STORAGE DISEASE TYPE V).


Hypoglossal Neuropathy, Traumatic
Twelfth Cranial Nerve Injuries
Hypoglossal Nerve Transection
Twelfth-Nerve Trauma
Injury, Twelfth Cranial Nerve
Injury, Cranial Nerve XII
Traumatic Twelfth-Nerve Palsy
Hypoglossal Nerve Avulsion
Hypoglossal Nerve Injuries
Cranial Nerve XII Injury
Hypoglossal Nerve Contusion
Twelfth-Nerve Palsy, Traumatic
Twelfth Cranial Nerve Injury
Hypoglossal Nerve Trauma

Traumatic injuries to the HYPOGLOSSAL NERVE.


Human Chemosignals
Human Pheromones
Pheromones, Human

Chemical substances excreted by humans that elicit behavior or physiological responses from other humans. Perception of these chemical signals may be olfactory or by contact.


Hyperkinesia, Generalized
Hyperkinesis
Hyperactivity, Motor
Hyperkinetic Movements
Hyperkinesia

Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.


Veins, Pulmonary
Vein, Pulmonary
Pulmonary Veins
Pulmonary Vein

The veins that return the oxygenated blood from the lungs to the left atrium of the heart.


Vinylbenzene
Styrene
Styrol
Styrene Monomer

A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.


Regulation of Gene Expression, Viral
Regulation, Gene Expression, Viral
Gene Expression Regulation, Viral
Viral Gene Expression Regulation

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.


A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.


Microsatellite repeats consisting of three nucleotides dispersed in the euchromatic arms of chromosomes.


Clinoxacin
Compound 64716
Cinoxacin
Cinobac
Azolinic Acid

Synthetic antimicrobial related to OXOLINIC ACID and NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.


Hypersensitivity, Drug
Allergy, Drug
Drug Hypersensitivity
Drug Allergy

Immunologically mediated adverse reactions to medicinal substances used legally or illegally.


Lateral Sinus
Transverse Sinuses
Sinus Transversus
Lateral Sinuses

The two large endothelium-lined venous channels that begin at the internal occipital protuberance at the back and lower part of the CRANIUM and travels laterally and forward ending in the internal jugular vein (JUGULAR VEINS). One of the transverse sinuses, usually the right one, is the continuation of the SUPERIOR SAGITTAL SINUS. The other transverse sinus is the continuation of the straight sinus.


Crypses
Biological Mimicry
Biological Camouflage
Mullerian Mimicry
Aposematism
Batesian Mimicry

The blending in of an organism with the colors and patterns of its physical environment or surroundings, such that it becomes indistinguishable from the latter.


Electrochemical Techniques
Electrochemical Technics

The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.


Extracranial Primitive Neuroectodermal Tumor

Primitive Neuroectodermal Tumor, Extracranial

Neuroectodermal Tumors, Primitive, Peripheral

(pPNET) Peripheral Primitive Neuroectodermal Tumors

Neuroectodermal Neoplasm, Peripheral Primitive

Peripheral Primitive Neuroectodermal Neoplasm

Neuroectodermal Tumor, Peripheral Primitive

A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.


Orchidectomy
Castration, Male
Orchiectomy

The surgical removal of one or both testicles.


A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown in some cases that the enzyme has a functional phosphate group, which can act as the donor. These were previously listed under PHOSPHOTRANSFERASES (EC 2.7.-). (From Enzyme Nomenclature, 1992) EC 5.4.2.


Antral Vascular Ectasia
Gastric Antral Vascular Ectasia
Watermelon Stomach

A distinct vascular lesion in the PYLORIC ANTRUM that is characterized by tortuous dilated blood vessels (ectasia) radiating outward from the PYLORUS. The vessel pattern resembles the stripes on the surface of a watermelon. This lesion causes both acute and chronic GASTROINTESTINAL HEMORRHAGE.


Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.


Ferricytochrome c
Cytochromes c
Cytochrome c
Ferrocytochrome c
Apocytochrome C

Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.


ATP Binding Cassette Transporter, Sub-Family A, Member 4

ATP Binding Cassette Transporter, Subfamily A, Member 4

Retinal-Specific ATP-Binding Cassette Transporter

An ATP binding cassette sub-family A transporter that translocates 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (RETINOIDS) from the extracellular surface to the cytoplasmic membrane surface of RETINAL ROD CELLS and RETINAL CONE CELLS. Mutations in the ABCA4 gene are associated with Stargardt Disease 1, a hereditary juvenile form of MACULAR DEGENERATION.


Prolixin
Fluphenazine Hydrochloride
Flufenazin
Fluphenazine
Lyogen

A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.


Adjuvants, Anesthesia
Anesthesia Adjuvants
Anesthetic Adjuvants

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.


Purchasing, Hospital
Hospital Purchasing
Hospital Purchasings
Purchasings, Hospital

Hospital department responsible for the purchasing of supplies and equipment.


Epidemiologic Surveillance
Epidemiologic Monitoring
Epidemiological Monitoring
Monitoring, Epidemiologic

Systematic and continuous collection, analysis, and interpretation of data about a disease or health condition, closely integrated with timely dissemination of results for use in planning, implementing, and evaluating public health programs.


Structurally-related alkaloids that contain the cevane carbon backbone.


Nitrous Oxide
Nitrogen Protoxide
Laughing Gas

Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.


Medicine, Environmental
Environmental Medicine

Medical specialty concerned with environmental factors that may impinge upon human disease, and development of methods for the detection, prevention, and control of environmentally related disease.


Pseudotuberculosis, Pasteurella
Yersinia pseudotuberculosis Infections
Infections, Yersinia pseudotuberculosis

Infections with bacteria of the species YERSINIA PSEUDOTUBERCULOSIS.


Gene Expression Regulation
Expression Regulation, Gene
Regulation, Gene Action
Regulation of Gene Expression
Regulation, Gene Expression
Gene Action Regulation

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.


Ricinoleic Acids
Oleic Acids, 12-hydroxy

Eighteen carbon fatty acids that comprise the great majority of CASTOR OIL, which is from the seed of RICINUS.


A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.


Either of a pair of tubular structures formed by DUCTUS DEFERENS; ARTERIES; VEINS; LYMPHATIC VESSELS; and nerves. The spermatic cord extends from the deep inguinal ring through the INGUINAL CANAL to the TESTIS in the SCROTUM.


Vascularized Composite Allografts
Composite Tissue Allografts

A graft consisting of multiple tissues, such as muscle, bone, nerve, vasculature, and skin, comprising a functional unit for reconstructive purposes.


Acetaldehyde Dehydrogenase 1
ALDH1 Enzyme
Aldehyde Dehydrogenase 1

A member of the Aldehyde Dehydrogenase family of enzymes involved in the synthesis of acetate from ethanol. It is also a tumor marker.


Respiratory Syncytial Virus Vaccines
RSV Vaccines

Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.


Refractive Disorders
Ametropia
Refractive Errors

Deviations from the average or standard indices of refraction of the eye through its dioptric or refractive apparatus.


A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.


Suprachiasmatic Nucleus
Suprachiasmatic Nuclei
Hypothalamic Suprachiasmatic Nuclei
Hypothalamic Suprachiasmatic Nucleus

An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.


Premammillary Nucleus
Area Hypothalamica Posterior
Posterior Periventricular Nucleus
Posterior Hypothalamic Region
Posterior Hypothalamus
Hypothalamic Region, Posterior
Supramammillary Commissure
Mammillary Region
Supramammillary Nucleus
Hypothalamus Posterior
Hypothalamus, Posterior

The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial maxillary nucleus, lateral mammillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.


Bloodborne Pathogens
Blood-Borne Pathogens
Pathogens, Blood-Borne

Infectious organisms, including pathogenic bacteria, viruses, and fungi, that are present in the BLOOD.


Hereditary Autoinflammatory Diseases
Reimann Periodic Disease
Hereditary Recurrent Fevers
Hereditary Periodic Fever Syndromes
Hereditary Autoinflammation Diseases
Siegal-Cattan-Mamou Disease

Hereditary inflammation conditions, characterized by recurrent episodes of systemic inflammation. Common symptoms include recurrent fever, rash, arthritis, fatigue, and secondary AMYLOIDOSIS. Hereditary autoinflammatory diseases are associated with mutations in genes involved in regulation of normal inflammatory process and are not caused by AUTOANTIBODIES, or antigen specific T-LYMPHOCYTES.


Prosthesis, Dental
Prostheses, Dental
Dental Prosthesis
Dental Prostheses

An artificial replacement for one or more natural teeth or part of a tooth, or associated structures, ranging from a portion of a tooth to a complete denture. The dental prosthesis is used for cosmetic or functional reasons, or both. DENTURES and specific types of dentures are also available. (From Boucher's Clinical Dental Terminology, 4th ed, p244 & Jablonski, Dictionary of Dentistry, 1992, p643)


Physiologic or biochemical monitoring of the fetus. It is usually done during LABOR, OBSTETRIC and may be performed in conjunction with the monitoring of uterine activity. It may also be performed prenatally as when the mother is undergoing surgery.


Brain Derived Neurotrophic Factor Receptor

Neurotrophic Tyrosine Kinase Receptor Type 2

Receptor, Neurotrophic Tyrosine Kinase Type 2

Neurotrophic Factor, Brain-Derived, Receptor

A protein-tyrosine kinase receptor that is specific for BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; neurotrophin 4 and neurotrophin 5. It is widely expressed in nervous tissue and plays a role in mediating the effects of neurotrophins on growth and differentiation of neuronal cells.


Fournier Gangrene
Fournier's Gangrene
Fournier Disease
Fournier's Disease

An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease.


Ataxin-2 Protein
ATXN2 Protein
Atx-2 Protein
Ataxin-2
SCA2 Protein
Spinocerebellar Ataxia Type 2 Protein

A Poly(A) RNA-binding protein that negatively regulates EGFR ENDOCYTOSIS. An increased risk for developing AMYOTROPHIC LATERAL SCLEROSIS 13 is observed in patients who have more than 23 CAG repeats in the ATXN2 gene coding sequence. Larger CAG expansions in the ATXN2 gene occur in SPINOCEREBELLAR ATAXIA 2 patients.


Blood Coagulation
Coagulation, Blood
Blood Clotting

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.


Peritonitis, Infectious, Feline
Infectious Peritonitis, Feline
Feline Infectious Peritonitis

Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.


Model, Neurological
Neurological Model
Neurological Models
Models, Neurological
Neurologic Models
Neurologic Model

Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.


Proto-Oncogene Protein c-yes
c-yes Protein
c-yes Proto-Oncogene Protein
yes Proto-Oncogene Protein
Proto-Oncogene Protein yes
Proto-Oncogene Proteins c-yes

Members of the src-family tyrosine kinases that are activated during the transition from G2 PHASE to M PHASE of the CELL CYCLE. It is highly homologous to PROTO-ONCOGENE PROTEIN PP60(C-SRC).


Laminin-5 Receptor (alpha3beta1 integrin)

Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.


Aquaporin-6
AQP6 Protein
Aquaporin 6
Aquaporin 6 Protein

Aquaporin 6 is an aquaglyceroporin that is found primarily in KIDNEY COLLECTING DUCTS. AQP6 protein functions as an anion-selective channel.


O-Demethylases
Oxidoreductases, O Demethylating
Oxidoreductases, O-Demethylating

Drug metabolizing enzymes which oxidize methyl ethers. Usually found in liver microsomes.


HSP30 Proteins
Heat-Shock Proteins 30
HSP30 Heat-Shock Proteins

A subfamily of small heat-shock proteins found in a wide variety of organisms.


Paraphilias
Sex Deviations
Paraphilic Disorders

Disorders that include recurrent, intense sexually arousing fantasies, sexual urges, or behaviors generally involving nonhuman objects, suffering of oneself or partners, or children or other nonconsenting partners. (from DSM-V)


Sinusitis, Maxillary
Maxillary Sinusitis

Inflammation of the NASAL MUCOSA in the MAXILLARY SINUS. In many cases, it is caused by an infection of the bacteria HAEMOPHILUS INFLUENZAE; STREPTOCOCCUS PNEUMONIAE; or STAPHYLOCOCCUS AUREUS.


alpha-Subunit, Receptor, Interleukin-15
IL-15R alpha
Interleukin-15 Receptor alpha
Interleukin-15 Receptor alpha Subunit

A low affinity interleukin-15 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-15.


Food and Drug Administration Drug Approval Process

Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.


Low Density Lipoprotein Receptor-Related Protein 6

Low Density Lipoprotein Receptor-Related Protein-6

An LDL-receptor related protein that combines with cell surface FRIZZLED RECEPTORS to form WNT PROTEIN-binding receptors. The protein plays an important role in the WNT SIGNALING PATHWAY during EMBRYONIC DEVELOPMENT and in regulation of vascular cell proliferation.


Entero-Septol 5-Chloro-7-iodo-8-quinolinol Chloroiodoquine Enteroquinol Iodochlorhydroxyquin Vioform Clioquinol Iodochloroxyquinoline Entero-Vioform Chinoform

A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.


PAAD-DAPIN-PYRIN Domain
DAPIN Domain
PADD Domain
PYD Domain
Pyrin Domain

A protein interaction domain of the death domain superfamily. It is characterized by a 6-helix bundle similar to those that occur in DEATH DOMAIN RECEPTORS. Pyrin domains are present in a variety of proteins, especially those that function in INFLAMMASOMES; AUTOPHAGY; and APOPTOSIS. They form homodimers or heterodimers with death domain proteins to facilitate the assembly of signaling complexes.


Neurologic Disorders
Nervous System Diseases
Neurological Disorders
Nervous System Disorders

Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.


Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)


Identification (Psychology)
Identification, Psychology
Identification, Psychological

A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others.


Vitamin E Deficiency
Deficiency, Vitamin E

A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)


A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-2-aminoadipate onto 2-oxoglutarate to generate 2-oxoadipate and L-GLUTAMATE.


Circulatory Arrest, Deep Hypothermia Induced

A technique to arrest the flow of blood by lowering BODY TEMPERATURE to about 20 degrees Centigrade, usually achieved by infusing chilled perfusate. The technique provides a bloodless surgical field for complex surgeries.


Dental Laboratories
Laboratories, Dental
Laboratory, Dental
Dental Laboratory

Facilities for the performance of services related to dental treatment but not done directly in the patient's mouth.


Nonmetropolitan Population
Suburbanization
Suburban Population

The inhabitants of peripheral or adjacent areas of a city or town.


Noscapine Hydrogen Embonate
Tuscalman
Capval Tropfen
Narcotine
Capval
Librochin Prikkelhoest
Noscapine Hydrochloride
Noscapect
Noscapine

A naturally occurring opium alkaloid that is a centrally acting antitussive agent.


Mycotic Infections, Ocular
Mycosis, Ocular
Fungal Eye Infections
Ocular Infections, Fungal
Oculomycosis
Eye Infections, Fungal

Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.


An isoform of DNA that occurs in an environment rich in SODIUM and POTASSIUM ions. It is a right-handed helix with 11 base pairs per turn, a pitch of 0.256 nm per base pair and a helical diameter of 2.3 nm.


Factor 12 Deficiency
Deficiency, Factor 12
Factor XII Deficiency
Factor Twelve Deficiency
Deficiency, Factor Twelve
Deficiency, Factor XII
Coagulation Factor 12 Deficiency
Hageman Trait
Hageman Factor Deficiency

An absence or reduced level of blood coagulation factor XII. It normally occurs in the absence of patient or family history of hemorrhagic disorders and is marked by prolonged clotting time.


Transmucosal Administration Routes
Mucosal Administration
Transmucosal Administration
Administration, Mucosal
Transmucosal Routing

Delivery of a drug or other substance into the body through the epithelium lining of MUCOUS MEMBRANE involved with absorption and secretion.


Scanning Tunnelling Microscopy
Microscopy, Scanning Tunneling
Scanning Tunneling Microscopy

A type of scanning probe microscopy in which a very sharp conducting needle is swept just a few angstroms above the surface of a sample. The tiny tunneling current that flows between the sample and the needle tip is measured, and from this are produced three-dimensional topographs. Due to the poor electron conductivity of most biological samples, thin metal coatings are deposited on the sample.


Male Genitourinary Diseases
Male Urogenital Diseases

Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).


Nurses
Nursing Personnel
Registered Nurses
Personnel, Nursing

Professionals qualified by graduation from an accredited school of nursing and by passage of a national licensing examination to practice nursing. They provide services to patients requiring assistance in recovering or maintaining their physical or mental health.


The act and process of chewing and grinding food in the mouth.


Valerian
Heliotrope, Garden
Valeriana officinalis
Valeriana

Valeriana officinalis L. is the official species but others have similar compounds and effects.


Fire Ant Venoms
Formicoidea Venoms
Ant Venoms
Ant Venom

Venoms from the superfamily Formicoidea, Ants. They may contain protein factors and toxins, histamine, enzymes, and alkaloids and are often allergenic or immunogenic.


Immunologic Technic
Technique, Immunologic
Immunological Technics
Immunologic Techniques
Immunologic Technique
Antibody Dissociation
Technics, Immunologic
Immunologic Technics
Immunological Techniques
Techniques, Immunologic
Technic, Immunologic

Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.


Diverticulitis, Colonic
Colonic Diverticulitis

Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.


Sports Veterinary Medicine
Veterinary Sports Medicine

The field of veterinary medicine concerned with PHYSICAL FITNESS of animals in sports (horse racing, dog racing, etc.) and the diagnosis and treatment of sports injuries in animals.


Keratoconjunctivitis, Infectious
Infectious Keratoconjunctivitis

Infectious diseases of cattle, sheep, and goats, characterized by blepharospasm, lacrimation, conjunctivitis, and varying degrees of corneal opacity and ulceration. In cattle the causative agent is MORAXELLA (MORAXELLA) BOVIS; in sheep, MYCOPLASMA; RICKETTSIA; CHLAMYDIA; or ACHOLEPLASMA; in goats, RICKETTSIA.


Administration, Sublingual
Sublingual Administration
Drug Administration, Sublingual
Sublingual Drug Administration

Administration of a soluble dosage form by placement under the tongue.


Hospital Departments
Departments, Hospital

Major administrative divisions of the hospital.


Circulating Cell-Derived Microparticles
Cell Membrane Microparticles
Ectosomes
Cell-Derived Microparticles
Shedding Microvesicles
Microparticles, Cell-Derived

Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.


Rubulavirus Infections
Infections, Rubulavirus

Infections with viruses of the genus RUBULAVIRUS, family PARAMYXOVIRIDAE.


Associate Nursing Education
Nursing Education, Associate
Education, Nursing, Associate

A two-year program in nursing education in a community or junior college leading to an A.D. (Associate Degree). Graduates of this program are eligible for state examination for licensure as RN (Registered Nurse).


Personality trait related to tendency to respond to threat, frustration or a loss with negative emotions (e.g., ANGER; ANXIETY; FRUSTRATION; embarrassment and sadness).


Olfactory Epithelium
Olfactory Membrane
Olfactory Mucosa

That portion of the nasal mucosa containing the sensory nerve endings for SMELL, located at the dome of each NASAL CAVITY. The yellow-brownish olfactory epithelium consists of OLFACTORY RECEPTOR NEURONS; brush cells; STEM CELLS; and the associated olfactory glands.


Native Polyacrylamide Gel Electrophoresis

Non-Denaturing Polyacrylamide Gel Electrophoresis

Polyacrylamide gel electrophoresis under conditions in which the components, such as PROTEINS, being separated can remain in their naturally folded state.


Green-Fluorescent Proteins
Green Fluorescent Proteins

Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.


Stenosis, Esophageal
Esophageal Stricture
Esophageal Stenosis

A stricture of the ESOPHAGUS. Most are acquired but can be congenital.


Dietary Sodium Chloride
Table Salt
Sodium Chloride, Dietary


Education, Professional, Retraining
Retraining, Professional

Educational programs for individuals who have been inactive in their profession, or who wish to regain unused skills.


alpha-Ketoacid Carboxylase
2-Oxo Acid Carboxy-Lyase
alpha-Carboxylase
Pyruvate Decarboxylase
Pyruvic Decarboxylase

Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.


Chromosomes, Human, Pair 21
Chromosome 21

A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.


Legislation, Food
Food Legislation
Food Laws

Laws and regulations concerned with industrial processing and marketing of foods and beverages.


Type B Trichothecenes
Trichothecenes, Type B

A subclass of Trichothecene derivatives that include the 12,13-epoxytrichothec-9-ene structure with a keto (carbonyl) function at C-8.


Work Performance
Job Performance
Performance at Work

Measure of how well an individual performs tasks in a work-related environment.


Aminopeptidases that remove METHIONINE from the amino-terminus of a peptide chain, such as the initiator METHIONINE found on nascent peptide chains.


Dynein Adenosinetriphosphatase
Dyneins
Adenosine Triphosphatase, Dynein
Adenosinetriphosphatase, Dynein
Dynein Intermediate Chains
Dynein
Dynein Heavy Chains
Dynein Light Chains
Dynein Light Intermediate Chains
ATPase, Dynein
Dynein ATPase

A family of multisubunit cytoskeletal motor proteins that use the energy of ATP hydrolysis, generated by a ring of AAA ATPASES in the dynein heavy chain, to power a variety of cellular functions. Dyneins fall into two major classes based upon structural and functional criteria.


An infraorder of New World monkeys, comprised of the families AOTIDAE; ATELIDAE; CEBIDAE; and PITHECIIDAE. They are found exclusively in the Americas.


Receptor, Platelet-Derived Growth Factor alpha

Platelet-Derived Growth Factor alpha Receptor

A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.


Superficial Musculo-aponeurotic System (SMAS)

Layer between the superficial fat compartment and superficial facial muscles in the head and the neck.


Dietary Approaches To Stop Hypertension Diet

Dietary recommendations that promote reduction in or prevention of high blood pressure. Recommendations include increasing intake of fruits and vegetables, and high-fiber, low-fat foods and reducing the intake of DIETARY SODIUM and high fat foods.


Dibasic Amino Acids
Amino Acids, Diamino
Diamino Amino Acids
Amino Acids, Dibasic


Tooth Bleaching
Tooth Whitening
Teeth Bleaching
Teeth Whitening

The use of a chemical oxidizing agent to whiten TEETH. In some procedures the oxidation process is activated by the use of heat or light.


Research Design, Epidemiologic
Design, Epidemiologic Research
Epidemiologic Research Design
Epidemiologic Research Designs
Designs, Epidemiologic Research
Research Designs, Epidemiologic
Epidemiological Research Design

The form and structure of analytic studies in epidemiologic research.


Works on or about records, usually private, of writers' experiences, observations, feelings, attitudes, etc. They may also be works marked in calendar order in which to note appointments and the like.


Basic Reproduction Ratio
Basic Reproductive Rate
Basic Reproduction Number

The expected number of new cases of an infection caused by an infected individual, in a population consisting of susceptible contacts only.


Sericins
Silk Gum Proteins
Sericin-1
Sericin

A serine-rich sticky protein secreted by MOTHS. Generally, the term refers to silkworm silk gum protein secreted in the middle section of silk gland cells of SILKWORMS, Bombyx mori. Sericin acts as a cement and coating for the two fibroin filaments in a silk strand and is readily soluble in mild alkaline solution.


Neoplasms, Circumanal Gland
Neoplasms, Anal Gland
Circumanal Gland Neoplasms
Perianal Gland Neoplasms
Neoplasms, Perianal Gland
Anal Gland Neoplasms


Acinic Cell Tumor
Acinar Carcinoma
Acinar Cell Adenocarcinoma
Carcinoma, Acinar Cell
Acinic Cell Adenocarcinoma
Serous Acinar Adenoma
Acinic Cell Carcinoma

A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)


A condition caused by the failure of body to dissipate heat in an excessively hot environment or during PHYSICAL EXERTION in a hot environment. Contrast to HEAT EXHAUSTION, the body temperature in heat stroke patient is dangerously high with red, hot skin accompanied by DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.


A therapy using IONIZING RADIATION where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.


Occupations, Allied Health
Allied Health Occupations

Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.


Gastrointestinal Stromal Neoplasm
Gastrointestinal Stromal Sarcoma
Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumor
Gastrointestinal Stromal Neoplasms

All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).


FERM Domains
Ezrin-like Domain
Band 4.1 Superfamily
FERM Domain
Band 4.1-Ezrin-Radixin-Moesin Domain

Widely occuring protein domains that function to link signaling and CYTOSKELETAL PROTEINS to the PLASMA MEMBRANE. They occur mostly at the N-terminal region of proteins that contain them.


Nuclear Receptor Subfamily 2 Group F Member 1

Chicken Ovalbumin Upstream Promoter-Transcription Factor I

A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.


Measurement and evaluation of the components of substances to be taken as FOOD.


Fibrofolliculomas with Trichodiscomas and Acrochordons

Autosomal dominant neoplastic syndrome characterised by genodermatosis, lung cysts, spontaneous and recurrent PNEUMOTHORAX; and RENAL CANCER. It is associated with mutations in the folliculin protein gene (FLCN protein).


Genetic Epidemiology
Molecular Epidemiology
Epidemiology, Molecular

The epidemiological evaluation of the role of inherited causes of disease in families and in populations; it aims to detect the inheritance pattern of a particular disease, localize the gene and find a marker associated with disease susceptibility. Gene-gene and gene-environment interactions are also studied in genetic epidemiology of a disease. In its broad context, genetic epidemiology includes family studies, molecular epidemiologic studies with genetic components, and more traditional cohort and case-control studies with family history components.


Receptor, Interleukin-5, alpha Subunit
Antigens, CD125
alpha-Subunit, Receptor, Interleukin-5
Interleukin-5 Receptor alpha Chain
CD125 Antigen
CD125 Antigens
Interleukin-5 Receptor alpha Subunit

A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING.


Thiamine Deficiency
Deficiency, Thiamine

A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)


Catheter-Related Infections
Catheter-Associated Infections

Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.


Women, Battered
Women, Abused
Woman, Abused
Abused Woman
Woman, Battered
Abused Women
Battered Women
Battered Woman

Women who are physically and mentally abused over an extended period, usually by a husband or other dominant male figure. Characteristics of the battered woman syndrome are helplessness, constant fear, and a perceived inability to escape. (From American Heritage Dictionary of the English Language, 3d ed)


Nasopharyngeal Diseases
Diseases of Nasopharynx

Pathological processes involving the NASOPHARYNX.


Procaine Penicillin
Benzylpenicillin Procaine
Penicillin G Procaine
Jenacillin

Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.


Public Health Schools
Schools, Public Health

Educational institutions for individuals specializing in the field of public health.


Pterygopalatine Ganglion Block
Sphenopalatine Ganglion Block

Method of treating pain associated with the sphenopalatine ganglion located in the PTERYGOPALATINE FOSSA, posterior to the middle nasal turbinate. The transnasal approach involves application of suitable local anesthetic to the mucous membrane overlying the ganglion.


Prisoner Dilemma
Prisoner's Dilemma
Prisoners Dilemma

A scenario in decision analysis in which two individuals motivated entirely by self-preservation at the expense of the other, end up in a worse state than if they had cooperated with each other in the decision-making process.


Proteolytic breakdown of the MITOCHONDRIA via autophagy.


Paleopallium
Primary Olfactory Cortex
Rhinencephalon
Olfactory Cortex
Regio Olfactoria
Anterior Olfactory Nucleus
Cortical Amygdala
Olfactory Brain
Olfactory Peduncle
Lateral Entorhineal Cortex
Olfactory Lobe

Basal forebrain and medial part of temporal lobe areas that receive synaptic inputs from the OLFACTORY BULB.


Dihydrodiolbenzopyrenes
Benzopyrene Dihydrodiols
Dihydrobenzopyrene Diols
Dihydroxydihydrobenzopyrenes

Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.


3-Iodobenzylguanidine, 125I Labeled
m-Iodobenzylguanidine
3-Iodobenzylguanidine, 123I Labeled
(3-Iodo-(131I)benzyl)guanidine
Iobenguane
Iobenguane (131I)
MIBG
meta-Iodobenzylguanidine
3-Iodobenzylguanidine

A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.


Therapy with Helminths
Helminthic Therapy

The treatment of immune system diseases by deliberate infestation with helminths. This therapy is partly based on the HYGIENE HYPOTHESIS which states that the absence of parasites increases immune dysregulation because of the lack of stimulation of REGULATORY T-CELLS.


Services for the diagnosis and treatment of disease and the maintenance of health.


A zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half.


Phosphatidylcholine
Phosphatidylcholines
Phosphatidyl Cholines
Choline Phosphoglycerides
Choline Glycerophospholipids
Phosphatidyl Choline

Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.


Rudeness
Incivility
Uncivil Behavior
Workplace Incivility

Low-intensity deviant behavior with ambiguous intent to harm the target, in violation of norms for mutual respect.


Meningofacial Angiomatosis-Cerebral Calcification Syndrome

A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.


Bis(1-methylethyl) Phosphorofluoridate
Di-isopropylphosphorofluoridate
Fluostigmine
Diisopropylfluorophosphate
Isoflurophate
Dyflos
Fluorostigmine
Diisopropylphosphofluoridate
Floropryl
DFP

A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.


Multicomponent ribonucleoprotein structures contained in MITOCHONDRIA that specialize in the PROTEIN BIOSYNTHESIS of a small number of proteins involved in energy production for the cell.


Transforming Growth Factor beta Superfamily Proteins

A large family of cell regulatory proteins which are structurally related to TRANSFORMING GROWTH FACTOR BETA. The superfamily is subdivided into at least three related protein families: BONE MORPHOGENETIC PROTEINS; GROWTH DIFFERENTIATION FACTORS; and TRANSFORMING GROWTH FACTORS.


An enzyme that catalyzes the synthesis of UDPgalactose from UTP and galactose-1-phosphate. It is present in low levels in fetal and infant liver, but increases with age, thereby enabling galactosemic infants who survive to develop the capacity to metabolize galactose. EC 2.7.7.10.


Macrophage Migration Inhibition Test
Macrophage Migration Test
Cell Migration Assays, Macrophage

Assays that measure the rate of migration of MACROPHAGES. They may involve the use hollow plastic chamber, sealed at one end with a porous membrane and suspended over a larger well which may contain CHEMOTACTIC FACTORS. The migration of cell through the pores to the other side of the membrane is measured.


Cinnamomum camphora
Camphor Laurel
Camphor Tree

A tree, Cinnamomum camphora (L.) J. Presl, known as the source of CAMPHOR.


Natural Cytotoxicity Triggering Receptor 3

A 30 kDa stimulatory receptor found on resting and activated NATURAL KILLER CELLS.


Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.


Armin
Ethyl-p-Nitrophenyl Ethylphosphonate
Armine

A reversible organophosphorus cholinesterase inhibitor. It also affects the presynaptic membrane and inhibits membrane postsynaptic cholinergic receptors. The compound had former use as a miotic.


Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.


Receptors, CCR10
CCR10 Receptors
CCR10 Receptor
G-Protein Coupled Receptor 2
CC Chemokine Receptor 10

CCR receptors with specificity for CHEMOKINE CCL27. They may play a specialized role in the cutaneous homing of LYMPHOCYTES.


Copper Transporters
Copper Transport Proteins

Membrane proteins that facilitate the transport of copper cations across biological membranes.


Health Services for the Aged
Geriatric Health Services
Health Services, Geriatric
Health Services for Aged
Health Services for the Elderly

Services for the diagnosis and treatment of diseases in the aged and the maintenance of health in the elderly.


Acetyl Coenzyme A-Acyl Carrier Protein Transacylase

A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to form COENZYME A and acetyl-acyl-carrier protein.


The membrane system of the CELL NUCLEUS that surrounds the nucleoplasm. It consists of two concentric membranes separated by the perinuclear space. The structures of the envelope where it opens to the cytoplasm are called the nuclear pores (NUCLEAR PORE).


Whipple's Disease
Lipodystrophy, Intestinal
Whipple Disease

A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.


RXR alpha Receptor
Retinoid X Receptor alpha

A nuclear transcription factor. Heterodimerization with PPAR GAMMA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES.


A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.


RNA, Small Cytoplasmic
scRNA
Small Cytoplasmic RNA

Small RNAs found in the cytoplasm usually complexed with proteins in scRNPs (RIBONUCLEOPROTEINS, SMALL CYTOPLASMIC).


Calcitonin Related Polypeptide Alpha
Calcitonin-1
Calcitonin Precursor Polyprotein
Procalcitonin
Pro-Calcitonin

A peptide prohormone precursor of CALCITONIN. It is normally present at low levels in serum, but is released into the bloodstream, primarily from neuroendocrine cells in the lungs and intestines, in response to INFLAMMATION and BACTERIAL INFECTIONS. It is a diagnostic marker for BACTEREMIA.


Dothiepin Hydrochloride
Dothiepin
Dosulepin
Prothiaden

A tricyclic antidepressant with some tranquilizing action.


Sezary's Lymphoma
Sezary Syndrome
Erythroderma, Sezary

A form of cutaneous T-cell lymphoma manifested by generalized exfoliative ERYTHRODERMA; PRURITUS; peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear (cerebriform) cells in the skin, LYMPH NODES, and peripheral blood (Sezary cells).


IL-10R1 Receptor
Antigens, CDW210A
Interleukin-10 Receptor alpha Subunit
Interleukin-10 Receptor alpha Chain
Interleukin-10 Receptor 1
CDW210A Antigens

A subunit of the interleukin-10 receptor. It plays a role in receptor signaling by associating with JANUS KINASE 1.


Geographic separation of members of a family.


Neovascularization, Choroidal
Choroid Neovascularization
Neovascularization, Choroid
Choroidal Neovascularization

A pathological process consisting of the formation of new blood vessels in the CHOROID.


Peptidyl Translocases
Peptidyl Transferases
Peptidyltransferase
Peptidyltransferases
Transpeptidases

Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.


Phaeomelanins Melanin Allomelanins Melanins


Technique, Dental Casting
Casting Technique, Dental
Casting Technics, Dental
Dental Casting Technics
Techniques, Dental Casting
Dental Casting Techniques
Dental Casting Technic
Technic, Dental Casting
Technics, Dental Casting
Casting Techniques, Dental
Dental Casting Technique
Casting Technic, Dental

The process of producing a form or impression made of metal or plaster using a mold.


Patent Foramen Ovale
Patent Oval Foramen
Foramen Ovale, Patent

A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.


Carotid Body Tumors
Paraganglioma, Carotid Body
Carotid Body Tumor

Benign paraganglioma at the bifurcation of the COMMON CAROTID ARTERIES. It can encroach on the parapharyngeal space and produce dysphagia, pain, and cranial nerve palsies.


Serotonin and Norepinephrine Uptake Inhibitors

Serotonin and Noradrenaline Uptake Inhibitors

Serotonin and Norepinephrine Reuptake Inhibitors

Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS.


HIV Envelope Glycoprotein gp120
Envelope Glycoprotein gp120, HIV
gp120 Envelope Glycoprotein, HIV
env Protein gp120, HIV
HIV Envelope Protein gp120
gp120(HIV)
HTLV-III gp120

External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.


Receptor-Tyrosine Kinase HEK2
HEK2 Protein
Cek10 Protein
EphB3 Receptor
Receptor, EphB3

An eph family receptor found in a number of tissues including BRAIN; LUNG; KIDNEY; PANCREAS; INTESTINE; and HEART. During embryogenesis EphB3 receptor is expressed at high levels in the brain.


Small Fibre Neuropathy
Small Nerve Fiber Neuropathy
Small Fiber Neuropathy

Disorder of the peripheral nerves that primarily impair small nerve fibers. The affected small nerve fibers include myelinated A-delta fibers (see A FIBERS) and unmyelinated C FIBERS. Because these small fibers innervate skin and help control autonomic function, their neuropathy presents with neuropathic pain, reduced thermal and pain sensitivity, and autonomic dysfunction (e.g. abnormal sweating or facial flushing). Small fiber neuropathy can be idiopathic or associated with underlying diseases (e.g., AMYLOIDOSIS; DIABETES MELLITUS; SARCOIDOSIS; or VASCULITIS).


A slightly acid milk food produced by fermentation due to the combined action of Lactobacillus acidophilus and Streptococcus thermophilus.


Urinary Antibody-Coated Bacteria Test
Antibody Coated Bacteria Test, Urinary
Antibody-Coated Bacteria Test, Urinary

Fluorescent antibody technique for visualizing antibody-bacteria complexes in urine. The presence or absence of antibody-coated bacteria in urine correlates with localization of urinary tract infection in the kidney or bladder, respectively.


Cerebellar Hemorrhage, Traumatic
Traumatic Brain Hemorrhage
Brain Hemorrhage, Traumatic

Bleeding within the brain as a result of penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA. Traumatically induced hemorrhages may occur in any area of the brain, including the CEREBRUM; BRAIN STEM (see BRAIN STEM HEMORRHAGE, TRAUMATIC); and CEREBELLUM.


An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.


AMP Kinase
Adenylokinase
ATP-AMP Phosphotransferase
Adenylate Kinase
ATP-AMP Transphosphorylase
Myokinase

An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC 2.7.4.3.


Galactosides in which the oxygen atom linking the sugar and aglycone is replaced by a sulfur atom.


A lymphohematopoietic cytokine that plays a role in regulating the proliferation of ERYTHROID PRECURSOR CELLS. It induces maturation of MEGAKARYOCYTES which results in increased production of BLOOD PLATELETS. Interleukin-11 was also initially described as an inhibitor of ADIPOGENESIS of cultured preadipocytes.


Databases, Pharmaceutic
Databases, Pharmaceutical
Databases, Drug

Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.


Metalloorganic Compounds
Metallo-Organic Compounds
Organometallic Compounds

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)


Genetic Transformation
Transformation, Genetic

Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.


Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.


The major protein constituents of milk are CASEINS and whey proteins such as LACTALBUMIN and LACTOGLOBULINS. IMMUNOGLOBULINS occur in high concentrations in COLOSTRUM and in relatively lower concentrations in milk. (Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed, p554)


Nurses Performance Evaluation
Employee Performance Appraisal
Family Planning Personnel Evaluation
Performance Appraisal, Employee

The assessment of the functioning of an employee in relation to work.


Elliptocytosis, Hereditary
Ovalocytosis, Hereditary

An intrinsic defect of erythrocytes inherited as an autosomal dominant trait. The erythrocytes assume an oval or elliptical shape.


pol Proteins, Human Immunodeficiency Virus

pol Gene Products, Human Immunodeficiency Virus

Proteins encoded by the POL GENE of the HUMAN IMMUNODEFICIENCY VIRUS.


Purulent infection of one of the sebaceous glands of Zeis along the eyelid margin (external) or of the meibomian gland on the conjunctival side of the eyelid (internal).


Test Anxiety Scale
Test Anxiety Questionnaire

A self-reporting test consisting of items concerning fear and worry about taking tests and physiological activity, such as heart rate, sweating, etc., before, during, and after tests.


Psychological Orientation
Orientation
Cognitive Orientation
Mental Orientation

Awareness of oneself in relation to time, place and person.


Thiostatin
Prokinins
Kininogens
Cystatins, Kininogen
T-Kininogen
Kininogen
Prekinins

Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.


Glycogen Debranching Enzyme
Transfer-Glucosidase
Glycogen Debranching Enzyme System

1,4-alpha-D-Glucan-1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase/dextrin 6 alpha-D-glucanohydrolase. An enzyme system having both 4-alpha-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33) activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or another 1,4-alpha-D-glucan. As a glucosidase it catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-1,6-glucosidase activity is deficient in glycogen storage disease type III.


An intermediate in the synthesis of cholesterol.


A DNA-methyltransferase that catalyzes the transfer of a methyl group from S-ADENOSYLMETHIONINE to the exocyclic NH2 group at the 4 position of CYTOSINE.


Self Expandable Metallic Stents
Self Expandable Metal Stents
Self Expandable Metallic Stent
Self Expandable Metal Stent

Cylindrical metallic tubes that are inserted to hold open a structure in order to treat vascular, bile duct, esophageal and other tubular organ constrictions.


Talusin
Proscillaridin A
Sandoscill
Scillase
Proscillaridine
Scillarenin Rhamnoside
Desglucotransvaaline
Caradrin
Proscillaridin
Digitalysat

A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).


Lateral Line Canal
Lateral Line System
Lateral Line Organs

Aquatic vertebrate sensory system in fish and amphibians. It is composed of sense organs (canal organs and pit organs) containing neuromasts (MECHANORECEPTORS) that detect water displacement caused by moving objects.


A family of transcription factors that contain two ZINC FINGER MOTIFS and bind to the DNA sequence (A/T)GATA(A/G).


Optically Stimulated Luminescent Dosimetry

Optically Stimulated Luminescence Dosimetry

The use of a radiation monitoring device composed of material which emits light after being illuminated. The amount of light emitted is proportional to the amount of IONIZING RADIATION to which the material has been previously exposed.


A MOLYBDENUM requiring enzyme that catalyzes the terminal reaction in the oxidative degradation of SULFUR AMINO ACIDS with the formation of a sulfate. A deficiency of sulfite oxidase results in sulfocysteinuria.


Muscarinic Acetylcholine Receptor
Muscarinic Receptor
Muscarinic Acetylcholine Receptors
Muscarinic Receptors
Receptors, Muscarinic

One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.


Twins, Siamese
Twins, Conjoined
Siamese Twins

MONOZYGOTIC TWINS who are joined in utero. They may be well developed and share only a superficial connection, often in the frontal, transverse or sagittal body plane, or they may share a partial duplication of a body structure. Alternatively, there may be a small and incompletely developed twin conjoined to a larger, more fully developed twin.


Group 2 Elements
Metals, Alkaline Earth
Alkaline Earth Metals

Metals that constitute the group 2 (formerly group IIa) of the periodic table.


Cell surface proteins that bind LIPOXINS with high affinity and trigger intracellular changes influencing the behavior of cells.


Germinoblastoma
Reticulolymphosarcoma
Lymphoma, Malignant
Sarcoma, Germinoblastic
Lymphoma

A general term for various neoplastic diseases of the lymphoid tissue.


Hydrazine substituted by one methyl group.


Mental Hygiene Services
Services, Mental Health
Health Services, Mental
Mental Health Services
Services, Mental Hygiene

Organized services to provide mental health care.


Dental Air Abrasion
Air Abrasion, Dental

A technique using a pneumatic, high-pressure stream of aluminum oxide to remove DENTAL ENAMEL; DENTIN; and restorative materials from teeth. In contrast to using DENTAL HIGH-SPEED EQUIPMENT, this method usually requires no dental anesthesia (ANESTHESIA, DENTAL) and reduces risks of tooth chipping and microfracturing. It is used primarily for routine DENTAL CAVITY PREPARATION.


A peroxiredoxin that is a cytosolic bifunctional enzyme. It functions as a peroxiredoxin via a single redox-active cysteine and also contains a Ca2+-independent acidic phospholipase A2 activity.


Gastric Chief Cells
Chief Cells, Gastric
Gastric Zymogenic Cells

Epithelial cells that line the basal half of the GASTRIC GLANDS. Chief cells synthesize and export an inactive enzyme PEPSINOGEN which is converted into the highly proteolytic enzyme PEPSIN in the acid environment of the STOMACH.


X Chromosome Inactivation
X-Inactivation
Lyon Hypothesis
X Inactivation
Lyonization

A dosage compensation process occurring at an early embryonic stage in mammalian development whereby, at random, one X CHROMOSOME of the pair is repressed in the somatic cells of females.


Behavior Observation Techniques
Behavioral Observation
Behavioral Observation Techniques
Behavior Observation

A wide range of formal and informal techniques used to document behavior.


Design, Dental Prosthesis
Prosthesis Designs, Dental
Dental Prosthesis Design
Dental Prosthesis Designs
Designs, Dental Prosthesis
Prosthesis Design, Dental

The plan and delineation of dental prostheses in general or a specific dental prosthesis. It does not include DENTURE DESIGN. The framework usually consists of metal.


Enteropathy, AIDS-Associated
Enteropathy, HIV-Associated
AIDS-Associated Enteropathy
HIV Enteropathy
Idiopathic AIDS Enteropathy
HIV-Associated Enteropathy
AIDS Enteropathy
Enteropathy, HIV

A syndrome characterized by chronic, well-established DIARRHEA (greater than one month in duration) without an identified infectious cause after thorough evaluation, in an HIV-positive individual. It is thought to be due to direct or indirect effects of HIV on the enteric mucosa. HIV enteropathy is a diagnosis of exclusion and can be made only after other forms of diarrheal illness have been ruled out. (Harrison's Principles of Internal Medicine, 13th ed, pp1607-8; Haubrich et al., Bockus Gastroenterology, 5th ed, p1155)


Protein-Calorie Malnutrition
Marasmus
Protein-Energy Malnutrition

The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.


A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)


Sulfamethizole
Sulfamethizol FNA
Sulphamethizole
Thiosulfil
Rufol


An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.


Ventricular Fibrillation with Prolonged QT Interval

A form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the VOLTAGE-GATED POTASSIUM CHANNEL.


Auxiliary, Hospital
Hospital Auxiliaries
Hospital Auxiliary
Auxiliaries, Hospital

Volunteer organizations whose members perform work for the hospital without compensation.


alpha Cells, Pancreatic
Pancreatic A Cells
Pancreatic alpha Cells
Glucagon-Secreting Cells

A type of pancreatic cell representing about 5-20% of the islet cells. Alpha cells secrete GLUCAGON.


Antitumor Drug Screens
Anticancer Drug Sensitivity Tests
Tumor-Specific Drug Screening Tests
Cancer Drug Tests
Drug Screening Tests, Tumor-Specific
Drug Screening Assays, Antitumor
Dye Exclusion Assays, Antitumor
Antitumor Drug Screening Assays
Anti-Cancer Drug Screens

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.


Alismatales Najas Alismatidae Ruppia Posidonia

A plant genus of the family Ruppiaceae, subclass ALISMATIDAE, class Liliopsida (monocotyledons).