Clinical Trials, Phase 1
Clinical Trials, Phase I as Topic
Drug Evaluation, FDA Phase 1
Phase I Clinical Trials
Clinical Trials, Phase I
Phase 1 Clinical Trials
Drug Evaluation, FDA Phase I
Microdosing Trials, Human
Human Microdosing Trials
Evaluation Studies, FDA Phase I
Drug Evaluation, FDA Phase I as Topic
Evaluation Studies, FDA Phase 1

Use of doses at only 1% of the pharmacological dose in humans in order to evaluate the pharmacokinetics. Such trials are sometimes referred to as phase zero trials.


Serotonin 4 Receptors
Receptors, Serotonin, 5-HT4
5-HT4 Receptor
Receptor, Serotonin 4
Receptors, Serotonin, 5-HT4S
Serotonin 4 Receptor
5-Hydroxytryptamine-4 Receptor
Receptors, Serotonin, 5-HT4L
5-HT4L Receptor
5-HT4S Receptor

A subtype of G-protein-coupled SEROTONIN receptors that preferentially couple to GS STIMULATORY G-PROTEINS resulting in increased intracellular CYCLIC AMP. Several isoforms of the receptor exist due to ALTERNATIVE SPLICING of its mRNA.


A third-generation oral cephalosporin antibacterial agent that is used to treat bacterial infections of the respiratory tract and skin.


Cyclam Derivatives
Bicyclams
1,4,8,11-Tetraazacyclotetradecane
Cyclens
Cyclams
Tetraazamacrocycles

Compounds made of fourteen-member tetraamine macrocycles which bind strongly to a wide range of metal ions.


A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.


Frenactil Glianimon Benperidol-neuraxpharm Benperidol Anquil

A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of aberrant sexual behavior. (From Martindale, The Extra Pharmacopoeia, 30th ed, p567)


TBI-698
Thioacetazon
Amithiozone
Parazone
Thioacetazone
TB I-698
Conteben
Thiacetazone
Ambathizon

A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217)


Oral Cavity Proper
Mouth
Cavitas oris propria
Vestibule Oris
Cavitas Oris
Mouth Cavity Proper
Oral Cavity
Vestibule of the Mouth

Part of the oral cavity bounded laterally and ventrally by the alveolar arches and their contained TEETH. Its roof is formed by the PALATE and it communicates posteriorly with the OROPHARYNX.


Nucleus Geniculatus Lateralis Pars Dorsalis

Part of the DIENCEPHALON inferior to the caudal end of the dorsal THALAMUS. Includes the lateral geniculate body which relays visual impulses from the OPTIC TRACT to the calcarine cortex, and the medial geniculate body which relays auditory impulses from the lateral lemniscus to the AUDITORY CORTEX.


Speech And Language Disorder With Orofacial Dyspraxia

A group of cognitive disorders characterized by the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function. The two major subtypes of this condition are ideomotor (see APRAXIA, IDEOMOTOR) and ideational apraxia, which refers to loss of the ability to mentally formulate the processes involved with performing an action. For example, dressing apraxia may result from an inability to mentally formulate the act of placing clothes on the body. Apraxias are generally associated with lesions of the dominant PARIETAL LOBE and supramarginal gyrus. (From Adams et al., Principles of Neurology, 6th ed, pp56-7)


Bleomycin A2
Bleomycin B(2)
Bléomycine Bellon
Bleomicina
Blenoxane
Blanoxan
Bleomycins
Bleomycin A(2)
Bleomycin
Bleomycin Sulfate
Bleomycin B2
Bleomycinum Mack
BLEO-cell
Bleolem

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.


Lin-Megestrol
Megace
Megefren
Megestat
Megostat
Maygace
Borea
Nu-Megestrol
Megestrol Acetate
Mestrel
Apo-Megestrol

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)


Amyxin
Amiksin
Bis-DEAE-Fluorenone
Tilorone
Amixin
Tilorone Hydrochloride

An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.


Konjac
Amorphophallus
Amorphophallus konjac

A plant genus of the family ARACEAE. Members contain konjac glucomannan (MANNANS) and SEROTONIN.


An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.


Glycogen Storage Disease Type II, Juvenile

Lysosomal alpha-1,4-Glucosidase Deficiency Disease

Deficiency Disease, Lysosomal alpha-1,4-Glucosidase

Glycogen Storage Disease Type II, Infantile

Juvenile Glycogen Storage Disease Type II

Infantile Glycogen Storage Disease Type II

An autosomal recessively inherited glycogen storage disease caused by GLUCAN 1,4-ALPHA-GLUCOSIDASE deficiency. Large amounts of GLYCOGEN accumulate in the LYSOSOMES of skeletal muscle (MUSCLE, SKELETAL); HEART; LIVER; SPINAL CORD; and BRAIN. Three forms have been described: infantile, childhood, and adult. The infantile form is fatal in infancy and presents with hypotonia and a hypertrophic cardiomyopathy (CARDIOMYOPATHY, HYPERTROPHIC). The childhood form usually presents in the second year of life with proximal weakness and respiratory symptoms. The adult form consists of a slowly progressive proximal myopathy. (From Muscle Nerve 1995;3:S61-9; Menkes, Textbook of Child Neurology, 5th ed, pp73-4)


A family of halophilic bacteria in the order Oceanospirillales. Its principal carbon and energy sources are linear-chain ALKANES and their derivatives.


Warm Ischemia
Warm Ischemia Time
Warm Ischemic Time

A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.


BH3 Interacting Domain Death Agonist Protein

A C-terminal fragment of Bid protein that is produced by caspase cleavage. tBID is the active from of the protein and it redistributes from the CYTOSOL to MITOCHONDRIA to promote release of CYTOCHROME C.


Sodium Para-Aminohippurate
p-Aminohippurate
Aminohippurate Sodium
Nephrotest
Aminohippuric Acid
p-Aminohippuric Acid
para-Aminohippuric Acid
4-Aminohippuric Acid

The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.


History, Early Modern
History, Early Modern 1451-1600
Early Modern Medicine
History of Medicine, Early Modern
Early Modern History (Medicine)
Early Modern History
Early Modern History of Medicine
Medicine, Early Modern

The period of the history of medicine from 1451 through 1600 A.D.


Auxin
Indolylacetic Acids
Indoleacetic Acids
Auxins

Organic compounds found in plant sprouts. They promote tissue growth through cell elongation rather than multiplication.


Tacaribe Complex Viruses
Chapare virus
New World Arenaviruses
American Hemorrhagic Fever Virus
Allpahuayo virus
Pirital virus
Arenaviruses, New World
Hemorrhagic Fever Viruses, American
Tacaribe virus
Guanarito virus
Hemorrhagic Fever Virus, Bolivian
Machupo virus
Sabia virus
Amapari virus

One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. It includes JUNIN VIRUS; PICHINDE VIRUS; Amapari virus, and Machupo virus among others. They are the cause of human hemorrhagic fevers mostly in Central and South America.


Selegiline, (R,S)-Isomer
Deprenyl
Yumex
Selegiline Hydrochloride, (R,S)-Isomer
Emsam
L-Deprenyl
Selegiline Hydrochloride, (S)-Isomer
Selegiline Hydrochloride, (R)-Isomer
Selegiline, (R)-Isomer
Humex
Jumex
Zelapar
Selegiline Hydrochloride
Eldepryl
Deprenil
Selegiline
Selegiline, (S)-Isomer
Selegyline
E-250
Deprenalin

A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl.


Biophysical Phenomena
Biophysical Concepts
Biophysical Phenomenon
Biophysical Processes
Biophysical Process

The physical characteristics and processes of biological systems.


A systemic agricultural fungicide used for control of certain fungal diseases of stone fruit.


An enzyme which catalyzes an endonucleolytic cleavage near PYRIMIDINE DIMERS to produce a 5'-phosphate product. The enzyme acts on the damaged DNA strand, from the 5' side of the damaged site.


Muscular Dystrophy Limb-Girdle with Alpha-Sarcoglycan Deficiency

Muscular Dystrophy, Limb-Girdle, Type 2D

Duchenne-Like Autosomal Recessive Muscular Dystrophy, Type 2

Limb girdle muscular dystrophies due to mutations in the gene for the ALPHA-SARCOGLYCAN or deficiencies in alpha-sarcoglycan due to a mutation in another gene (secondary alpha-sarcoglycanopathy).


Avidity, Antibody
Antibody Affinity
Affinity, Antibody
Antibody Avidity

A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.


Bisphosphonate-Associated Osteonecrosis of the Jaws

Osteonecrosis of the Jaws, Bisphosphonate-Induced

Bisphosphonate-Related Osteonecrosis of the Jaw

Osteonecrosis of the Jaws, Bisphosphonate-Related

Bisphosphonate-Induced Osteonecrosis of the Jaws

Osteonecrosis of the Jaw, Bisphosphonate-Associated

Osteonecrosis of the Jaws, Bisphosphonate-Associated

Osteonecrosis of the Jaw, Bisphosphonate-Related

Osteonecrosis of the Jaw, Bisphosphonate-Induced

Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.


Contraception, Hormonal
Contraception, Female Hormonal
Male Hormonal Contraception
Contraception, Male Hormonal
Hormonal Contraception
Female Hormonal Contraception

Contraceptive methods that utilize HORMONAL CONTRACEPTIVE AGENTS.


Horizontal Gene Transfer
Lateral Gene Transfer
Recombination, Interspecific
Recombination, Interspecies
Gene Transfer, Horizontal
Gene Transfer, Lateral

Recombination occurring between genes from different species.


Japanese Summer-Type Hypersensitivity Pneumonitis

Fungal infections caused by TRICHOSPORON that may become systemic especially in an IMMUNOCOMPROMISED HOST. Clinical manifestations range from superficial cutaneous infections to systemic lesions in multiple organs.


Cancer of the Testis
Cancer of Testis
Tumor of Rete Testis
Neoplasms, Testis
Testicular Cancer
Testis Neoplasms
Testicular Neoplasms
Neoplasms, Testicular
Testis Cancer
Testicular Tumors
Cancer of the Testes

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.


Receptors, Long-Acting Thyroid Stimulator

Receptors on the thyroid cells that bind the LONG-ACTING THYROID STIMULATOR or LATS, the abnormal immunoglobulins that consist of various anti-TSH receptors and anti-thyroid antibodies.


Ambulatory Care Facilities, Non-Hospital

Ambulatory Care Facilities, Non Hospital

Free-standing walk-in facilities that generally specialize in treating a disease, illness, or injury presented on an episodic basis. The disease, illness or injury is usually acute and non-life-threatening.


A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.


Radiotherapy, Lymphatic
Lymphatic Radiation Therapy
Radiation Therapy, Lymphatic
Irradiation, Lymphoid
Lymphoid Irradiation
Lymphatic Radiotherapy
Lymphatic Irradiation
Irradiation, Lymphatic
Therapy, Lymphatic Radiation

External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.


Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1

Oxidized Low-Density Lipoprotein Receptor 1

A class of oxidized LDL receptors that contain C-type lectin-like extracellular domains.


Cloprostenol
Cloprostenol Sodium
Estrumate
Oestrophan
ICI-80,966
Cloprostenol Monosodium Salt

A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle.


Human Coxsackievirus A24
Coxsackie A24 Variant Virus
Enterovirus C, Human
Coxsackievirus A24, Human
Coxsackievirus A24 Variant
Human Enterovirus C

A species of ENTEROVIRUS infecting humans and containing 11 serotypes, all coxsackieviruses.


Consequentialism
Utilitarianism
Ethics, Deontological
Teleological Ethics
Ethical Theory
Ethics, Teleological
Deontological Ethics
Normative Ethics

An ethical theory which holds that the morality of an act or a policy can be determined by whether it produces the greatest net benefit. (Bioethics Thesaurus)


Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.


Ubiquitously expressed integral membrane glycoproteins found in the LYSOSOME.


Anterodorsal Thalamic Nucleus
Anterior Nucleus of Thalamus
Anterior Thalamus
Anterior Thalamic Nuclei
Anteroventral Thalamic Nucleus
Anteromedial Nucleus
Anterodorsal Nucleus
Anteroventral Nucleus
Anterior Thalamic Nucleus
Anteromedial Thalamic Nucleus
Anterior Nuclear Group

Three nuclei located beneath the dorsal surface of the most rostral part of the thalamus. The group includes the anterodorsal nucleus, anteromedial nucleus, and anteroventral nucleus. All receive connections from the MAMILLARY BODY and BRAIN FORNIX, and project fibers to the CINGULATE BODY.


Taxes
Taxation
Institutional Taxes
Tax
Institutional Tax

Governmental levies on property, inheritance, gifts, etc.


Pumps, Heart-Assist
Vascular-Assist Devices
Artificial Ventricle
Heart-Assist Devices
Heart Ventricle, Artificial
Ventricular Assist Device
Ventricle-Assist Device

Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.


Vesicular Skin Diseases
Skin Diseases, Vesiculobullous
Sneddon-Wilkinson Disease
Skin Diseases, Bullous
Skin Diseases, Vesicular
Subcorneal Pustular Dermatosis
Bullous Skin Diseases
Vesiculobullous Skin Diseases
Bullous Dermatoses
Vesiculobullous Dermatoses
Pustular Dermatosis, Subcorneal

Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)


Ethiodan Isophendylate Iofendylate Pantopaque Ioglunide Iophendylate Panthopaque Iodophendylate Myodil Maiodil

An inert iodine-containing agent which is opaque to X-RAYS. It is used mainly for BRAIN and SPINAL CORD visualization.


Marantic Endocarditis
Non-Bacterial Thrombotic Endocarditis
Non-Infective Endocarditis
Endocarditis, Non-Infective
Endocarditis, Non-Bacterial Thrombotic

Formation of a non-infectious THROMBUS, referred to as vegetation, on previously undamaged ENDOCARDIUM. It usually occurs as a complication of connective-tissue diseases and cancers because of the associated hypercoagulable state (see THROMBOPHILIA).


Leader Sequences, Peptide
Signal Sequences, Peptide
Signal Sequences
Protein Sorting Signals
Signal Sequence, Peptide
Signal Peptides
Signal Peptide
Leader Signal Peptides
Peptide Leader Sequences
Peptide Signal Sequences
Leader Peptide

Highly hydrophobic amino acid sequences of proteins that must cross through membranes to arrive at their functioning cellular location (such as secreted and membrane proteins). They are 15 to 60 amino acids long and reside at the amino-terminus (leader signal peptides) or internally. By binding to signal recognition particles, these sequences direct nascent protein-ribosome complexes to a membrane where the protein is inserted during translation. Signal peptides direct translational uptake of the protein by various membranes -endoplamic reticulum, mitochondrial, chloroplast, peroxisomal, etc. Leader signal sequences on non-membrane proteins are ultimately removed by specific peptidases.


Myelinolysis, Central Pontine
Myelinoclasis, Central Pontine
Central Pontine Myelinolysis
Pontine Myelinolysis, Central
Extrapontine Myelinoclasis
Extrapontine Myelinolysis

A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)


Angioscopic Surgery
Surgery Angioscopic
Angioscopic Surgical Procedures
Surgical Procedures, Angioscopic
Angioscopy

Endoscopic examination, therapy or surgery performed on the interior of blood vessels.


Hydroxybutyrates
Hydroxybutyric Acids
Hydroxybutyric Acid Derivatives

Salts and esters of hydroxybutyric acid.


E-Cadherin
Cadherins
Neural Cadherins
N-Cadherins
Cadherin-3
P-Cadherin
N-Cadherin
E-Cadherins
Placental Cadherins
Liver Cell Adhesion Molecule
P-Cadherins
Epithelial-Cadherins
Cadherin-2
Cadherin-1
Liver Cell Adhesion Molecules
Uvomorulin

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.


Micronuclei, Genotoxicant-Induced
Chromosome-Defective Micronuclei
Micronuclei, Chromosome-Defective
Genotoxicant-Induced Micronuclei
Micronucleus, Chromosome-Defective

Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.


Nettlespurge
Spurge, Nettle
Jatropha
Physic Nut
Purging Nut
Jatropha curcas

A plant genus of the family EUPHORBIACEAE. Members contain jatrophone and other diterpenes.


Buserelin
Profact
Buserelin Acetate
Suprefact
Tiloryth
Receptal
Bigonist
Suprecur
HOE-766

A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.


Thymic Neoplasms
Thymus Neoplasms
Cancer of the Thymus
Neoplasms, Thymus
Thymic Cancer
Cancer of Thymus
Thymus Tumors
Thymic Tumors
Thymus Cancer
Neoplasms, Thymic


GTP-Binding Protein alpha Subunits, Gi-Go

A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to inhibit ADENYLYL CYCLASES. Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.


An imagined sequence of events or mental images, e.g., daydreams.


Clonidine Hydrochloride
Catapresan
Hemiton
Chlophazolin
Clofelin
Dixarit
Clonidine Dihydrochloride
Clofenil
Clonidine
Klofenil
Klofelin
Gemiton
Catapressan
Clonidine Monohydrochloride
Clopheline
Isoglaucon
Clonidine Monohydrobromide
ST-155
M-5041T
Catapres

An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.


Henbane
Hyoscyamus niger
Hyoscyamus
Black Henbane

A plant genus of the family SOLANACEAE which contains TROPANES.


Capzasin
Gelcen
Zostrix
Axsain
NGX-4010
8-Methyl-N-Vanillyl-6-Nonenamide
Capsicum Farmaya
Katrum
Antiphlogistine Rub A-535 Capsaicin
Capsaicine
Zacin
Capsin
Capsidol
Capsaicin

An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.


Spike Glycoprotein S1, Coronavirus
Spike Protein, Coronavirus
Spike Glycoprotein, Coronavirus
Glycoprotein S, Coronavirus
Spike Gp S1, Cor
E2 Spike Glycoprotein, Coronavirus
Spike Protein S2, Coronavirus
Spike Glycoproteins, Coronavirus

A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.


Nails, Abnormal
Pachyonychia
Nails, Malformed
Nail Abnormalities


Saccharide-Mediated Cell Adhesion Molecules

Saccharide Mediated Cell Adhesion Molecules

Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.


Self Blood Pressure Monitoring
Monitoring, Ambulatory Blood Pressure
Ambulatory Blood Pressure Monitoring
Home Blood Pressure Monitoring
Blood Pressure Monitoring, Home
Blood Pressure Monitoring, Self
Blood Pressure Monitoring, Ambulatory


Butylcarbamide Diabetal Carbutamide Sulfaninylbutylurea Glucidoral Oranil Glybutamide Bukarban Oranyl Bucarban Aminophenurobutane

A sulfonylurea antidiabetic agent with similar actions and uses to CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)


Experimental Sarcomas
Sarcoma, Jensen
Sarcoma, Engelbreth-Holm-Swarm
Experimental Sarcoma
Sarcomas, Experimental
Sarcoma, Experimental
EHS Tumor

Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.


Oncoviruses, Type C
Leukemogenic Viruses
Oncovirinae
Retroviruses
Oncornaviruses
RNA Tumor Viruses
Oncoviruses
Leukoviruses
Type C Oncoviruses
Retroviridae

Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).


Nonpancreatic Secretory Phospholipase A2

Synovial Fluid Secretory Phospholipase A2

A subcategory of secreted phospholipases A2 that includes enzymes isolated from a variety of sources. The creation of this group is based upon similarities in the structural determinants of the enzymes including a negatively charged carboxy-terminal segment.


A plant genus of the family FABACEAE known for its sour fruit.


Acetobutolol
Prent
Acebutolol Hydrochloride
Monitan
M & B 17803A
Neptal
M&B-17803 A
Rhotral
Apo-Acebutolol
Sectral
Novo-Acebutolol
Acebutolol

A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action.


Populations, Underserved
Disadvantaged
Sensitive Population Groups
Sensitive Populations
Patients, Underserved
Vulnerable Populations

Patient groups that may include those with special needs, homeless people, those with low income, or in remote communities and minority groups


Stem Cell Renewal
Cell Self Renewal
Stem Cell Self-Renewal

The ability of STEM CELLS to divide while maintaining an undifferentiated state. This process perpetuates the stem cell pool throughout the life of an organism.


Trifolium pratense
Trifolium repens
Red Clover
Clover, Red
Trifolium


A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.


Adenosis of Breast
Mammary Dysplasia
Fibrocystic Disease of Breast
Microglandular Adenosis
Cystic Disease of Breast
Breast Dysplasia
Cystic Breast Disease
Fibrocystic Mastopathy
Chronic Cystic Mastitis
Fibrocystic Changes of Breast
Fibrocystic Breast Disease

A benign lesion of the BREAST, characterized by a proliferation of disorganized small glands lined by EPITHELIAL CELLS without apparent myoepithelial cells. These glands usually have enlarged lumens, and lie in adipose or fibrous tissue.


Insulin Glargine
Lantus
Insulin, Gly(A21)-Arg(B31,B32)
Lantus Solostar
A21-Gly-B31-Arg-B32-Arg-insulin
Basaglar
Glargine
Insulin, Glycyl(A21)-Arginyl(B31,B32)
HOE 901
HOE-901

A recombinant LONG ACTING INSULIN and HYPOGLYCEMIC AGENT that is used to manage BLOOD GLUCOSE in patients with DIABETES MELLITUS.


Continental Population Groups
Race
Racial Stocks

Groups of individuals whose putative ancestry is from native continental populations based on similarities in physical appearance.


Nasopharyngeal Cancer
Neoplasms, Nasopharyngeal
Nasopharyngeal Neoplasms
Cancer of Nasopharynx
Cancer of the Nasopharynx
Nasopharynx Neoplasms
Nasopharynx Cancer


Diaryl Heptanoids
Diarylheptanoids
Linear Diarylheptanoids
Diarylheptanones
Acyclic Diarylheptanoids
Cyclic Diarylheptanoids
Curcuminoids
Diarylheptanoid Derivatives

A group of compounds consisting of two aryl rings linked by seven carbons (HEPTANES) which may be acyclic (linear) or cyclic. It is a group of secondary metabolites in polyketide synthesis pathway best exemplified by a linear diarylheptanoid CURCUMIN.


Neuroses, War
War Neurosis
War Neuroses
Combat Stress Disorders
Combat Neuroses
Combat Disorders
Combat Neurosis
Shell Shock

Reactions to fierce combat or operations other than war, which may be both physical and psychological.


Pemphigoid, Ocular Cicatricial
Cicatricial Pemphigoid, Ocular
Pemphigoid, Benign Mucous Membrane
Ocular Cicatricial Pemphigoid
Mucous Membrane Pemphigoid, Benign
Benign Mucosal Pemphigoid
Pemphigoid, Cicatricial
Benign Mucous Membrane Pemphigoid

A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.


Liver Steatosis
Fatty Liver
Steatohepatitis
Steatosis of Liver
Visceral Steatosis

Inflammation of the liver related to lipid accumulation in fatty liver.


Nurses, Community Health
Home Nurses
Visiting Nurses
Health Visitors
Home Health Nurses

A registered NURSE employed by a public health agency or hospital to promote community health and to visit and administer treatment to sick people in their homes.


Speech or Language, Developmental Disorder

Developmental Disorder, Speech or Language

Conditions characterized by language abilities (comprehension and expression of speech and writing) that are below the expected level for a given age, generally in the absence of an intellectual impairment. These conditions may be associated with DEAFNESS; BRAIN DISEASES; MENTAL DISORDERS; or environmental factors.


Collagen XVIII
Collagen Type XVIII
Procollagen Type XVIII
alpha1(XVIII) Collagen
Collagen alpha1(XVIII)
Type XVIII Collagen
Collagen Type XVIII, alpha1 Subunit
XVIII Collagen

A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.


Cystoscopic Surgery
Cystoscopy
Surgery, Cystoscopic
Cystoscopic Surgical Procedures
Surgical Procedures, Cystoscopic

Endoscopic examination, therapy or surgery of the urinary bladder.


Ribophagy
Autophagy, Cellular
Lipophagy
Nucleophagy
Autophagocytosis
Reticulophagy
ER-Phagy
Autophagy

Lysosomal degradation of ENDOPLASMIC RETICULUM by MACROAUTOPHAGY or MICROAUTOPHAGY.


Toxic Shock Syndrome
Shock, Endotoxic
Shock, Septic
Shock, Toxic
Septic Shock

Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.


Propantheline
Pro-Banthine
Propantheline Bromide
Probanthine

A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.


Thiobacillus neapolitanus
Halothiobacillus neapolitanus
Halothiobacillus

The type species of HALOTHIOBACILLUS, formerly called Thiobacillus neapolitanus.


Ryanodine Receptor Calcium Release Channel

A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.


Designs, Experimental
Research Proposal
Design, Experimental
Research Design
Research Strategy
Matched Groups
Error Sources
Data Reporting
Research Methodology
Experimental Designs
Research Technics
Research Techniques
Methodology, Research
Data Adjustment
Scoring Methods
Experimental Design
Problem Formulation

A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.


Competency, Clinical
Clinical Skills
Competence, Clinical
Skill, Clinical
Clinical Competency
Clinical Competence
Clinical Skill
Skills, Clinical

The capability to perform acceptably those duties directly related to patient care.


Animals, Feral
Animals, Nondomestic
Animals, Wild
Stray Animals
Animals, Nondomesticated

Domesticated animals that are living in the wild.


Parakeet, Rose-ringed
Psittacula krameri
Psittacula

A genus in the family PSITTACIDAE containing three species of PARAKEETS: the Derbyan, the Alexandrine, and the rose-ringed.


Blood Cell Count, White
Leukocyte Number
Differential Leukocyte Count
Leukocyte Count, Differential
Leukocyte Count
White Blood Cell Count

The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.


Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.


Skull Fracture, Non-Depressed
Skull Fracture, Linear
Linear Skull Fracture
Skull Fractures
Non-Depressed Skull Fracture

Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).


Mediastinoscopic Surgical Procedures
Surgical Procedures, Mediastinoscopic
Surgery, Mediastinoscopic
Mediastinoscopy
Mediastinoscopic Surgery

Endoscopic examination, therapy or surgery of the anterior superior mediastinum of the thorax.


MK 0787-MK 0791 mixture
Tienam 500
Imipenem Cilastatin
Thienam
Primaxin
Imipenem Cilastatin Sodium
Cilastatin, Imipenem Drug Combination
Imipenem - Cilastatin Sodium
Imipenem - Cilastatin
Zienam
MK 787-MK 791 mixture
Imipenem-Cilastatin Sodium
Imipenem-Cilastatin, Sodium Salt
Imipenem-Cilastatin

Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent.


European Molecular Biology Laboratory Nucleotide Sequence Database

Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.


Squint
Strabismus
Nonconcomitant Strabismus
Hypertropia
Strabismus, Comitant
Phorias
Dissociated Vertical Deviation
Concomitant Strabismus
Convergent Comitant Strabismus
Strabismus, Noncomitant
Non-Concomitant Strabismus
Mechanical Strabismus

Misalignment of the visual axes of the eyes. In comitant strabismus the degree of ocular misalignment does not vary with the direction of gaze. In noncomitant strabismus the degree of misalignment varies depending on direction of gaze or which eye is fixating on the target. (Miller, Walsh & Hoyt's Clinical Neuro-Ophthalmology, 4th ed, p641)


Human Pancreatic Growth Hormone-Releasing Factor

Ectopic GHRH secreted by human pancreatic tumor.


Soluble N-ethylmaleimide-Sensitive-Factor Attachment Protein Receptor

A superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. They share a homologous SNARE motif. The SNARE proteins are divided into subfamilies: QA-SNARES; QB-SNARES; QC-SNARES; and R-SNARES. The formation of a SNARE complex (composed of one each of the four different types SNARE domains (Qa, Qb, Qc, and R)) mediates MEMBRANE FUSION. Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e., SNAPs (no relation to SNAP 25.)


Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.


Alfentanyl
R-39209
Limifen
Alfentanil
Alfenta
Rapifen
Fanaxal
Alfentanil Hydrochloride

A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.


Albers-Schonberg Disease, Autosomal Dominant

Osteopetrosis, Autosomal Dominant, Type II

Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).


Colestipol Hydrochloride
Colestid
U-26,597 A
Colestipol HCl
Colestipol

Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.


A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.


Toxicology
Evidence-Based Toxicology
Toxinology
Evidence Based Toxicology

The science concerned with the toxins produced by bacteria, plants, and animals.


Neuromuscular Agents
Neuromuscular Effect
Neuromuscular Effects
Skeletal Muscle Relaxants

Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.


Boots Bite & Sting Relief
Anthisan
Kriptin
Mepyramine Maleate
Mepyramine
Pyrilamine
Pyrilamine Maleate
Pyranisamine

A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.


Unmedicated IUDs
Contraceptive IUD
Contraceptive Devices, Intrauterine
Contraceptive IUDs
IUD, Unmedicated
Intrauterine Devices

Contraceptive devices placed high in the uterine fundus.


Adrenergic Drugs
Adrenergic Effect
Sympathetic Transmitter Releasers
Adrenergic Release Inhibitors
Adrenergic Neuron Drugs
Adrenergic Synthesis Inhibitors
Adrenergic Neuron Agents
Adrenergic Agents
Adrenergic Effects
Adrenergic Neurohumor Depleters
Adrenergics

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.


Interferon, beta
Interferon-beta
beta-1 Interferon
Interferon-beta1
Fiblaferon
beta-Interferon
Interferon, beta-1
Interferon, Fibroblast

A non-recombinant from of Interferon-beta.


Digitek
Lanoxicaps
Hemigoxine Nativelle
Lanoxin
Digoregen
Digacin
Lenoxin
Lanoxin-PG
Dilanacin
Digoxine Nativelle
Lanacordin
Lanicor
Mapluxin
Digoxina Boehringer
Digoxin

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)


Blue Nevus
Cellular Blue Nevus
Blue Nevi
Blue Nevus, Cellular
Nevus, Blue
Cellular Blue Nevi

Usually a benign tumor, that commonly presents as a solitary blue nodule with spindled MELANOCYTES covered by smooth SKIN. Several variants have been identified, one variant being malignant. The blue color is caused by large, densely packed melanocytes deep in the DERMIS of the nevus. In CHILDREN, they usually occur on the BUTTOCKS and LUMBOSACRAL REGION and are referred to as cellular blue nevi. Malignant blue nevi are more commonly found on the SCALP.


Dyskeratosis Congenita, X-Linked
Dyskeratosis Congenita
Zinsser-Cole-Engman Syndrome

A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.


Electronic Publishing
Publishing, Electronic
Publishing

"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.


Pancreatitis, Acute Hemorrhagic
Hemorrhagic Pancreatitis
Pancreatitis, Acute Haemorrhagic
Haemorrhagic Pancreatitis

An acute INFLAMMATION of the PANCREAS in which the initial edematous pancreatitis evolved into necrosis accompanied by HEMORRHAGE.


Linoleic Acid, (Z,Z)-Isomer, 14C-Labeled

Linoleic Acid, Potassium Salt, (Z,Z)-Isomer

Linoleic Acid, Ammonium Salt, (Z,Z)-Isomer

Linoleic Acid, Sodium Salt, (Z,Z)-Isomer

Linoleic Acid, Sodium Salt, (E,E)-Isomer

Linoleic Acid, Calcium Salt, (Z,Z)-Isomer

A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)


Health Services, University
Student Health Services
Services, Student Health
Health Services, Student
Services, University Health
University Health Services

Health services for college and university students usually provided by the educational institution.


Diet, Formula
Diet, Synthetic
Dietary Formulations
Chemically Defined Diet
Diet, Elemental
Food, Formulated
Diet, Chemically Defined
Synthetic Diet

Food and dietary formulations including elemental (chemically defined formula) diets, synthetic and semisynthetic diets, space diets, weight-reduction formulas, tube-feeding diets, complete liquid diets, and supplemental liquid and solid diets.


An organophosphate cholinesterase inhibitor that is used as an insecticide.


Interventional Ultrasonography
Ultrasonography, Interventional
Ultrasound, Interventional
Intravascular Ultrasonography
Ultrasonography, Intravascular

The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.


Heart Enlargement
Heart Hypertrophy
Cardiac Hypertrophy
Cardiomegaly
Enlarged Heart

Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.


Schools
Secondary Schools
Primary Schools
Schools, Secondary


An antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.


Emergency Medical Dispatch
911 Dispatch
9-1-1 Dispatch

The mobilization of EMERGENCY CARE to the locations and people that need them.


Ovine Digital Dermatitis
Bovine Digital Dermatitis
Bovine Hairy Footwarts
Digital Papillomatosis
Bovine Foot Warts
Papillomatous Digital Dermatitis
Digital Dermatitis

Highly contagious infectious dermatitis with lesions near the interdigital spaces usually in cattle. It causes discomfort and often severe lameness (LAMENESS, ANIMAL). Lesions can be either erosive or proliferative and wart-like with papillary growths and hypertrophied hairs. DICHELOBACTER NODOSUS and TREPONEMA are the most commonly associated causative agents for this mixed bacterial infection disease.


Anaprilin
Propranolol Hydrochloride
Propanolol
Betadren
Rexigen
Inderal
Propranolol
Anapriline
Dociton
Dexpropranolol
Obsidan
Avlocardyl
AY-20694
Obzidan

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.


Mitotic Spindle
Meiotic Spindle Apparatus
Mitotic Apparatus
Mitotic Spindle Apparatus
Meiotic Spindle
Spindle Apparatus
Spindle Apparatus, Mitotic

Microtubular array that forms at the start of MEIOSIS and acts to separate sister CHROMATIDS during meiotic division. It is similar in structure and function to the MITOTIC SPINDLE APPARATUS that forms during MITOSIS.


Cote d'Ivoire ebola virus
Zaire Ebola Virus
Ebola-like Viruses
Ebola Virus, Zaire
Reston Ebola Virus
Sudan Ebola Virus
Ebola Virus
Ebola Virus, Reston
Ebolavirus
Ebola Virus, Sudan
Ebola Virus, Cote d'Ivoire

A species in the genus EBOLAVIRUSES causing an outbreak of disease in 1994 in western Africa's Cote d'Ivoire.


An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA.


Hangman's Fracture
Hangman Fracture
Spinal Fractures


Nonne-Milroy Lymphedema
Lymphedema, Early-Onset
Primary Congenital Lymphedema
Congenital Familial Lymphedema
Milroy's Disease
Early Onset Lymphedema
Nonne-Milroy Disease
Lymphedema
Hereditary Lymphedema
Milroy Disease
Hereditary Lymphedema 1
Lymphedema, Hereditary, Ia
Congenital Hereditary Lymphedema
Hereditary Lymphedema Type I
Nonne-Milroy-Meige Disease

Edema due to obstruction of lymph vessels or disorders of the lymph nodes.


Leishmania leishmania
Leishmania
Leishmania (Viannia)
Leishmania (Leishmania)
Leishmania viannia

A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi.


History of Medicine, Modern
History, Modern 1601-
History, Modern
Modern History
Modern Medicine
Medicine, Modern
Modern History (Medicine)

The period of the history of medicine from 1601 A.D. to the present.


Piper cubeba
Piper longum
Cubeb Pepper
Pepper, Ashanti
Pepper, Jaborandi
Pepper, Cubeb
Long Pepper
Piper
Piper guineense

A plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.


Dentistry, Industrial
Industrial Dentistry
Occupational Dentistry
Dentistry, Occupational

The branch of dentistry concerned with maintaining oral health of employees in occupational environments.


CD230 Antigen
Creutzfeldt-Jakob Disease Protein
Fatal Familial Insomnia Protein
Prion Protein
Major Prion Protein
Prion Proteins
PrP Proteins
AltPrP
Alternative Prion Protein

An overlapping open reading frame within the PRNP gene that encodes a protein which is smaller and structurally unrelated to major prion protein.


rab1A GTP-Binding Protein
rab1 GTP-Binding Proteins
rab1A Protein
rab1 GTP-Binding Protein
rab1 Protein

A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in vesicle transport between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS and through early Golgi compartments. This enzyme was formerly listed as EC 3.6.1.47.


Nitroprusside, Disodium Salt, Dihydrate
Nipruton
Cyanonitrosylferrate
Nitroprussiat Fides
Nitropress
Naniprus
Nipride
Nitroferricyanide
Ketostix
Nitroprusside
Nitriate
Nitroprusside, Disodium Salt
Sodium Nitroprusside

A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.


ICI-46474
Tamoxifen
ICI-47699
Tomaxithen
Soltamox
Zitazonium
Tamoxifen Citrate
Nolvadex
ICI-46,474
Novaldex

One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.


Photosensitizing Effects
Photosensitizing Effect
Photosensitizers
Photosensitizing Agents

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.


Adenylic Acid
Adenosine Phosphate Disodium
Adenosine Phosphate Dipotassium
2'-AMP
Adenosine 3'-Phosphate
AMP
Adenosine Monophosphate
Phosphaden
2'-Adenylic Acid
Adenosine 2'-Phosphate
5'-Adenylic Acid
2'-Adenosine Monophosphate
Adenosine 5'-Phosphate

Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.


Thoracic Outlet Nerve Compression Syndrome

Nerve Compression Syndrome, Thoracic Outlet

A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).


Caries Resistance, Dental
Dental Caries Susceptibility
Dental Caries Resistance
Resistance, Dental Caries
Caries Susceptibility, Dental
Susceptibility, Dental Caries

The predisposition to tooth decay (DENTAL CARIES).


Gastroscopic Surgical Procedures
Surgery, Gastroscopic
Gastroscopy
Surgical Procedures, Gastroscopic
Gastroscopic Surgery

Endoscopic examination, therapy or surgery of the interior of the stomach.


Phenyl Ethers
Diphenyl Ethers
Diphenyl Oxides

Ethers that are linked to a benzene ring structure.


Calcium Inhibitors, Exogenous
Channel Blockers, Calcium
Exogenous Calcium Blockaders
Calcium Channel Antagonists
Calcium Antagonists, Exogenous
Calcium Channel Blockers
Calcium Channel Blocking Drugs
Calcium Blockaders, Exogenous
Exogenous Calcium Inhibitors
Exogenous Calcium Antagonists

A class of drugs that act by selective inhibition of calcium influx through cellular membranes.


Snus
Gutka Tobacco
Oral Tobacco
Snuff
Chewing Tobacco
Dipping Tobacco
Mint Snuff
Smokeless Tobacco
Gutka
Tobacco, Smokeless

Any product of NICOTIANA TABACUM that is not smoked but is either inhaled through the nose, chewed, or stored in cheek pouches.


Camelus bactrianus
Bactrian Camels
Camels
Dromedary
Camelus
Camelus dromedarius
Bractrian Camels

A camel with one hump, native to North Africa and the Middle East.


Respiratory Chain Deficiencies, Mitochondrial

Mitochondrial Respiratory Chain Deficiencies

Electron Transport Chain Deficiencies, Mitochondrial

Mitochondrial Electron Transport Chain Deficiencies

Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.


Leukotomy Psychosurgery Gyrectomy Lobotomy Topectomy Leucotomy

Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.


Lowland Paca
Pacas
Cuniculidae
Cuniculus paca
Agoutidae
Cuniculus
Agouti paca


Metabolism Concepts
Anabolism
Catabolism
Metabolic Process
Process, Metabolic
Processes, Metabolic
Metabolic Processes
Metabolic Phenomena
Metabolism Phenomena
Metabolic Concepts
Metabolism
Metabolic Phenomenon

The chemical reactions in living organisms by which energy is provided for vital processes and activities and new material is assimilated.


Synapses, Electrical
Gap Junctions, Neuronal
Electrotonic Synapses
Synapses, Electrotonic
Neuronal Gap Junctions
Electrical Synapses

Specialized junctions between NEURONS which connect the cytoplasm of one neuron to another allowing direct passage of an ion current.


Promyelocytes
Premyelocytes
Granulocyte Progenitors
Myelocytes
Metamyelocytes
Progranulocytes
Granulocytic Precursor Cells
Myeloblasts
Myeloblast
Granulocyte Precursor Cells
Granulocyte Progenitor Cells

The cells in the granulocytic series that are derived from myeloblasts and that are the earliest cells of the myelocyte stage.


Yellow Mutant Albinism
Albinism, Tyrosinase-Negative
Oculocutaneous Albinism
Albinism, Tyrosinase-Positive
Albinism, Yellow-Mutant
Albinism, Oculocutaneous

Heterogeneous group of autosomal recessive disorders comprising at least four recognized types, all having in common varying degrees of hypopigmentation of the skin, hair, and eyes. The two most common are the tyrosinase-positive and tyrosinase-negative types.


Bushmaster
European Adder
Azemiopinae
Bitis
Viperinae
Viperidae
True Vipers
Lachesis
European Viper
Gaboon Viper
Cerastes
Asp

A family of snakes comprising four subfamilies: Azemiopinae (the mountain viper, the sole member of this subfamily), Viperinae (true vipers), Crotalinae (pit vipers) and Causinae. They are widespread throughout the world, being found in the United States, Central and South America, Europe, Asia and Africa. Their venoms act on the blood (hemotoxic) as compared to the venom of elapids which act on the nervous system (neurotoxic). (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp333-36)


Serine-Threonine Protein Kinase Receptor R6

Type IB Bone Morphogenetic Protein Receptor

Type IA Bone Morphogenetic Protein Receptor

Type I Bone Morphogenetic Protein Receptors

Bone Morphogenetic Protein Receptor Type I

Bone Morphogenetic Protein Receptors, Type I

Bone Morphogenetic Protein Receptor, Type IB

Bone Morphogenetic Protein Receptor, Type IA

A subtype of bone morphogenetic protein receptors with high affinity for BONE MORPHOGENETIC PROTEINS. They can interact with and undergo PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II. They signal primarily through RECEPTOR-REGULATED SMAD PROTEINS.


2-butenedioic acid, (2E)-, dimethyl ester

A fumarate derivative that is used as a DERMATOLOGIC AGENT in the treatment of PSORIASIS and SKIN DISEASES. It also may be used as an IMMUNOSUPPRESSIVE AGENT in the treatment of MULTIPLE SCLEROSIS.


IgG Receptors
Antigens, CD16
Fc Receptors, gamma
Immunoglobulin G Receptor
Fc gamma RIII
CD64 Antigens
Fc gamma Receptors
CD 32 Antigens
Receptors, IgG
Fc gamma RII
CD 16 Antigens
Antigens, CD32
CDw32 Antigens
CD32 Antigens
gamma Fc Receptors
Antigens, CD64
CD16 Antigens
Fc gamma RI
Receptors, Fc gamma
CD 64 Antigens
Leu-11 Antigens

Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).


RNA Interference
Post-Transcriptional Gene Silencing
Posttranscriptional Gene Silencing
Co-Suppression
RNAi
RNA Silencing
Gene Silencing, Post-Transcriptional
Cosuppression

Joint gene silencing of extra copies of genes, such as TRANSGENES, along with the original endogenous gene. Cosuppression is induced by the presence of the extra gene copies via mechanisms that are related to RNA INTERFERENCE.


Carsickness
Car Sickness
Seasickness
Airsickness
Sea Sickness
Motion Sickness
Air Sickness

Disorder caused by motion. It includes sea sickness, train sickness, roller coaster rides, rocking chair, hammock swing, car sickness, air sickness, or SPACE MOTION SICKNESS. Symptoms include nausea, vomiting and/or dizziness.


Acute Pain Service
Multidisciplinary Pain Clinics
Pain Centers
Multidisciplinary Pain Centers
Pain Service, Acute
Pain Clinics
Pain Relief Units

Facilities providing diagnostic, therapeutic, and palliative services for patients with severe chronic pain. These may be free-standing clinics or hospital-based and serve ambulatory or inpatient populations. The approach is usually multidisciplinary. These clinics are often referred to as "acute pain services". (From Br Med Bull 1991 Jul;47(3):762-85)


Amiloride Hydrochloride
Amiloberag
Kaluril
Midoride
Modamide
Midamor
Amiduret Trom
Amiloride
Amidal
Amiloride Hydrochloride, Anhydrous

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)


Cellolax
Ruspol
Carboxymethylcellulose
Aquaplast
Carboxymethyl Cellulose
Sodium Carboxymethylcellulose
Cethylose
Polycell
Carboxymethylcellulose Sodium
Croscarmellose Sodium
Carmellose Sodium
Aquacel

A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.


DUST mixture of many specific substances which may include fabric fibers, human SKIN particles, animal dander, MITES; BACTERIA; FUNGAL SPORES; food particles, and/or parts of COCKROACHES.


Agkistrodon
Copperhead
Black Moccasin
Swamp Moccasin
Ancistrodon
Cottonmouth
Water Mocassin

A genus of venomous snakes of the subfamily Crotalinae. Twelve species of this genus are found in North and Central America and Asia. Agkistrodon contortrix is the copperhead, A. piscivorus, the cottonmouth. The former is named for its russet or orange-brown color, the latter for the white interior of its mouth. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336; Moore, Poisonous Snakes of the World, 1980, p75)


Emotional Depression
Depression
Depressive Symptoms

Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.


Retinoschisis, Juvenile, X Chromosome-Linked

X chromosome recessive disorder, found nearly exclusively in males and becoming apparent around puberty. Characterized initially by a cystlike structure involving the FOVEA CENTRALIS, a peripheral retinoschisis occurs in about half the patients.


Pulsed Laser Tissue Ablation
Laser Tissue Ablation
Nonablative Laser Treatment
Laser Knife
Laser Ablation
Laser Therapy
Laser Surgery
Laser Scalpel
Vaporization, Laser
Surgery, Laser
Laser Photoablation of Tissue
Laser Knives

The utilization of photothermal effects of LASERS to denature COLLAGEN without destroying tissue.


Scorbo-bétaïne
Lycine
Betaine
Hepastyl
Acidin-Pepsin
Novobetaine
Cystadane
Oxyneurine
C.B.B.
Citrate de Bétaïne UPSA
Glycine Betaine
Stea-16
Betaine Hydrochloride
Citrate de Bétaïne Beaufour

A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)


Cystathionine beta-Synthase Deficiency Disease

Deficiency Disease, Cystathionine beta-Synthase

Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)


Chromium-Cobalt Alloys
Chromium Alloys
Cobalt-Chromium Alloys
Chromium-Nickel Alloys
Nickel-Chromium Alloys

Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.


Processes and properties of the MUSCULOSKELETAL SYSTEM.


Exercise-Induced Asthma
Exercise-Induced Bronchospasm
Bronchospasm, Exercise-Induced
Asthma, Exercise-Induced

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).


Quassia simarouba
Simarouba
Simarouba amara

A plant genus of the family SIMAROUBACEAE. Members produce quassinoids.


Cytotoxic T lymphocyte-Associated Antigen 8

A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.


Peripheral Autonomic Nervous System Diseases

Autonomic Peripheral Nervous System Diseases

Nervous System Diseases, Parasympathetic

Disorders of the Autonomic Nervous System

Autonomic Central Nervous System Diseases

Central Autonomic Nervous System Diseases

Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.


Post-Traumatic Brainstem Hemorrhage
Pontine Hemorrhage, Traumatic
Medullary Hemorrhage, Traumatic
Bulbar Hemorrhage, Traumatic
Brain Stem Hemorrhage, Post-Traumatic
Post-Traumatic Brain Stem Hemorrhage
Brain Stem Hemorrhage, Traumatic
Traumatic Brainstem Hemorrhage
Brain Stem Hematoma, Traumatic
Brainstem Hematoma, Traumatic
Brainstem Hemorrhage, Traumatic
Traumatic Brain Stem Hematoma
Hemorrhage, Brain Stem, Traumatic
Midbrain Hemorrhage, Traumatic
Traumatic Brain Stem Hemorrhage

Bleeding into structures of BRAIN STEM, including the MIDBRAIN; PONS; or MEDULLA OBLONGATA, as the result of CRANIOCEREBRAL TRAUMA. DIFFUSE AXONAL INJURY is commonly associated. Clinical manifestations may include OCULAR MOTILITY DISORDERS; ATAXIA; PARALYSIS; PERSISTENT VEGETATIVE STATE; and COMA.


Bovine Leukosis
Enzootic Bovine Leukosis
Lymphoma, Bovine
Bovine Lymphosarcoma
Bovine Lymphoma
Leukemia, Bovine
Leukosis, Bovine
Bovine Leukemia
Lymphosarcoma, Bovine

A lymphoid neoplastic disease in cattle caused by the bovine leukemia virus. Enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukemia but the presence of malignant cells in the blood is not a consistent finding.


An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)


Clopidogrel Napadisilate
SC 25989C
Clopidogrel-Mepha
SC 25990C
SR 25989
Clopidogrel Besylate
Plavix
Clopidogrel Bisulfate
Clopidogrel, (+)(S)-isomer
Clopidogrel Besilate
Clopidogrel Sandoz
PCR 4099
PCR-4099
Clopidogrel Hydrochloride
Iscover
Clopidogrel

A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.


Fasciola lanceolata
Dicrocoelium dendriticum
Dicrocoelium
Fasciola dendritica
Dicrocoelium lanceolatum

A genus of trematode liver flukes of the family Dicrocoeliidae which includes the species dendriticum and hospes. It occurs in the biliary passages or liver of many vertebrates including man. The intermediate hosts are mainly mollusks but occasionally ants.


Levulosado Bieffe Medit
Fructose
Levulosa Baxter
Plast Apyr Levulosa Mein
Levulosado Braun
Levulosado Vitulia
Levulose
Levulosa Grifols
Levulosa Braun
Fleboplast Levulosa
Apir Levulosa
Levulosa
Levulosa Mein
Levulosa Ife
Levulosa Ibys

A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.


Branched-Chain alpha-Keto Acid Dehydrogenase Deficiency

Maple Syrup Urine Disease, Thiamine-Responsive

Maple Syrup Urine Disease, Thiamine Responsive

Thiamine Responsive Maple Syrup Urine Disease

An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain amino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a "maple syrup" odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)


Noonan Syndrome
Pseudo-Ullrich-Turner Syndrome
Ullrich-Noonan Syndrome
Turner Syndrome, Male
Turner Phenotype with Normal Karyotype
Turner's Syndrome, Male
Familial Turner Syndrome
Male Turner Syndrome
Female Pseudo-Turner Syndrome
Turner's Phenotype, Karyotype Normal
Noonan-Ehmke Syndrome
Turner-Like Syndrome
Noonan Syndrome 1

A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.


Embryonic Organizers
Spemann Organizer
Spemann's Organizer
Embryo Organizers
Organizers, Embryonic
Hensen Node
Hensen's Node

The knot at the tip of the PRIMITIVE STREAK.


Institutional Animal Care and Use Committees

Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).


HIV-1 Enhancer
NF-kappa B-Binding Site, HIV
HIV NF-kappa B-Binding Site
NF-kB-Binding Site, HIV
NF-kB Binding Site, HIV
HIV Enhancer

Cis-acting regulatory sequences in the HIV long terminal repeat (LTR) which play a major role in induction or augmentation of HIV gene expression in response to environmental stimuli such as mitogens, phorbol esters, or other viruses. The HIV enhancer is the binding site for many cellular transcription factors including the nuclear factor NF-kappa B.


Lotus arabicus
Lotus corniculatus
Lotus japonicus
Loteae
Lotus
Trefoil

A genus of the PEA FAMILY. The genus Lotus, formerly known as Tetragonolobus, is unrelated to other plants with the common name of lotus (NELUMBO and NYMPHAEA).


An azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.


International Classification of Disease Codes

International Classification of Diseases

International Statistical Classification of Diseases and Related Health Problems

A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.


A plant genus of the family CRASSULACEAE. Members contain rhodioloside. This roseroot is unrelated to the familiar rose (ROSA). Some species in this genus are called stonecrop which is also a common name for SEDUM.


Cold-Stress Reaction
Cold Shock Stress
Cold Stress
Cold-Stress Response
Cold-Shock Response
Cold Shock

A sequence of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.


Diclophenac
Dicrofenac
Diclofenac Potassium
Diclofenac
Feloran
Diclofenac Sodium
SR-38
Novapirina
Dichlofenal
Voltarol
Sodium Diclofenac
Diclonate P
Orthofen
GP-45,840
Orthophen
Ortofen
Voltaren

The sodium form of DICLOFENAC. It is used for its analgesic and anti-inflammatory properties.


Dizzyness Dizziness Orthostasis Lightheadedness Light-Headedness

An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.


Simian parvovirus
Erythrovirus
Parvovirus, Simian

Species of Erythrovirus affecting cynomolgus monkeys and highly similar to PARVOVIRUS B19, HUMAN.


Infant Obesity
Childhood Onset Obesity
Pediatric Obesity
Adolescent Obesity
Obesity in Adolescence
Infantile Obesity
Childhood Obesity
Adolescent Overweight
Childhood Overweight
Infant Overweight
Obesity in Childhood
Child Obesity

BODY MASS INDEX in children (ages 2-12) and in adolescents (ages 13-18) that is grossly above the recommended cut-off for a specific age and sex. For infants less than 2 years of age, obesity is determined based on standard weight-for-length percentile measures.


Benzindamine
Ratio-Benzydamine
Benzydamine
Benzydamine Monohydrochloride
Lonol
Sun-Benz
Tantum Topico
Novo-Benzydamine
Rosalgin
Tantum
Opalgyne
PMS-Benzydamine
Benzidamine
Difflam
Benzydamine Hydrochloride

A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.


Monitoring, Radioimmunological
Radioimmunologic Monitoring
Monitoring, Immunological
Immunosurveillance
Immunologic Monitoring
Monitoring, Radioimmunologic
Monitoring, Immune
Immune Monitoring
Monitoring, Immunologic

Testing of immune status in the diagnosis and therapy of cancer, immunoproliferative and immunodeficiency disorders, and autoimmune abnormalities. Changes in immune parameters are of special significance before, during and following organ transplantation. Strategies include measurement of tumor antigen and other markers (often by RADIOIMMUNOASSAY), studies of cellular or humoral immunity in cancer etiology, IMMUNOTHERAPY trials, etc.


Mycobacterium abscessus subspecies bolletii

Mycobacterium abscessus subspecies abscessus

Mycobacterium abscessus subsp. abscessus

A rapidly growing non-tuberculous environmental mycobacterium causing OPPORTUNISTIC INFECTION that infects the skin and subcutaneous tissues. It is associated with HEALTH CARE ASSOCIATED INFECTION and causes serious lung infections in persons with various chronic lung diseases.


Pulvinar Thalamus
Anterior Pulvinar Nucleus
Oral Pulvinar Nucleus
Medial Pulvinar Nucleus
Pulvinar Nucleus
Lateral Pulvinar Nucleus
Inferior Pulvinar Nucleus
Pulvinar
Nucleus Pulvinaris
Pulvinar Thalami

Large mass of nuclei forming the most caudal portion of the THALAMUS and overhanging the GENICULATE BODIES and the dorsolateral surface of the MIDBRAIN. It is divided into four parts: the lateral, medial, inferior, and oral pulvinar nuclei.


Psacalium putlanum
Psacalium
Indianbush
Psacalium decompositum
Matarique
Odontotrichum decompositum
Desert Indianbush
Psacalium peltatum
Cacalia decomposita

A genus of the Asteraceae family. Several of its species are used in TRADITIONAL MEDICINE.


Affective Disorders, Psychotic
Mood Disorders, Psychotic
Depression, Reactive, Psychotic
Psychotic Mood Disorders
Psychotic Affective Disorders
Psychoses, Affective

Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.


Tetrathionic Acid, Disodium Salt, Dihydrate

A sulfuric acid dimer, formed by disulfide linkage. This compound has been used to prolong coagulation time and as an antidote in cyanide poisoning.


Netilmicin Sulfate
Netillin
Certomycin
Netromycin
Netromycine
Nétromicine
Netilmicin
Sch-20569
Netrocin
Netromicina

Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.


Arthrospira maxima
Arthrospira
Spirulina
Spirulina maxima

Filamentous, screw-like coiled cyanobacteria.


Gynipral
Hexoprenaline
Hexoprenaline Sulfate
St-1512
Ipradol
Ginipral

Stimulant of adrenergic beta 2 receptors. It is used as a bronchodilator, antiasthmatic agent, and tocolytic agent.


Askenazy Cells
Hurthle Cells
Oncocytes
Oxyphil Cells

Oxyphil cells in the thyroid gland are known as Hurthle cells and Askenazy cells.


Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.


Cancer of Thyroid
Thyroid Carcinoma
Neoplasms, Thyroid
Thyroid Cancer
Thyroid Neoplasms
Cancer of the Thyroid
Thyroid Adenoma


Pipecuronium Dibromide, (16 alpha)-Isomer

Pipecuronium Dibromide, (17 alpha)-Isomer

A piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (NEUROMUSCULAR NONDEPOLARIZING AGENTS). It is used as a muscle relaxant during ANESTHESIA and surgical procedures.


Intraoperative ECoG
Extraoperative ECoG
Electrocorticography
Extraoperative Electrocorticography
Electrocorticography (EcoG)
Intracranial Electroencephalography
Intraoperative Electrocorticography
Intracranial EEG

Recording of brain electrical activities in which the electrodes are placed directly on the CEREBRAL CORTEX.


An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.


Procamide
Biocoryl
Procan
Procanbid
Procainamide
Rhythmin
Novocamid
Pronestyl
Apo-Procainamide
Procan SR
Procaine Amide
Novocainamide
Procainamide Hydrochloride

A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.


Polyacrylamide Gel Electrophoresis, Two-Dimensional

Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.


A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide.


Glucorticoid Effects
Glucocorticoid
Glucocorticoids
Glucocorticoid Effect

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.


Hypocatalasemia
Hypocatalasia
Acatalasia
Acatalasemia Swiss Type
Acatalasemia
Takahara's Disease
Acatalasemia Japanese Type
Takahara Disease
Catalase Deficiency

A rare autosomal recessive disorder resulting from the absence of CATALASE activity. Though usually asymptomatic, a syndrome of oral ulcerations and gangrene may be present.


Chemokine CCL4L2
Chemokine CCL4L1
CCL4L2 Chemokine
CCL4 Chemokine
MIP-1beta
Macrophage Inflammatory Protein-1beta2
Macrophage Inflammatory Protein 1-beta
Chemokine CCL4
CCL4L1 Chemokine

A CC chemokine with specificity for CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES and a variety of other immune cells. This chemokine is encoded by multiple genes.


National Health and Nutrition Examination Survey

A systematic collection of factual data pertaining to the nutritional status of a human population within a given geographic area. Data from these surveys are used in preparing NUTRITION ASSESSMENTS.


Operative Surgical Procedures
Surgical Procedures, Operative
Procedures, Operative Surgical
Operative Procedures
Ghost Surgery
Surgical Procedure, Operative
Surgery, Ghost
Operative Surgical Procedure
Procedure, Operative Surgical

Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.)


Reflex, Dento-Cardiac
Reflex, Trigemino-Cardiac
Reflex, Dentocardiac
Reflex, Trigeminocardiac

Trigeminocardiac reflex variant seen during TOOTH EXTRACTION procedures.


5-Aminolevulinate
Aminolevulinic Acid
5-Aminolaevulinate
Delta-Aminolevulinic Acid
Levulan
Aminolevulinic Acid Hydrochloride

A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.


Glutamate Agonist
Excitatory Amino Acid Agonists
Amino Acid Agonists, Excitatory
Glutamate Agonists
EAA Agonist
EAA Agonists
Excitatory Amino Acid Agonist
Amino Acids, Excitatory, Agonists
Agonists, Excitatory Amino Acid
Amino Acid Agonist, Excitatory

Drugs that bind to and activate excitatory amino acid receptors.


Posterior Inferior Tibiofibular Ligament

Ligamentum Laterale Articulationis Talocruralis

LATERAL LIGAMENTS of the ANKLE JOINT. It includes inferior tibiofibular ligaments.


Infection, Central Nervous System, Protozoal

Protozoal Infections, Central Nervous System

Central Nervous System Protozoal Infections

Infections, Protozoal, Central Nervous System

Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.


Counterfeit Medicines
Fake Drugs
Falsified Drugs
Counterfeit Drugs
Falsified Medicines

Drugs whose formulation does not agree with the information stated on the packaging.


Flowcharts
Flow Charts (Computer)
Software Design
Flowcharts (Computer)

Specifications and instructions applied to the software.


Stellaria
Stellaria media
Common Chickweed

A plant genus of the family Caryophyllaceae.


Propithecus
Indriidae
Avahi
Indri
Indri indri
Woolly Lemurs

A family of primates of the superfamily LEMUROIDEA, suborder STREPSIRRHINI containing genera AVAHI (woolly lemurs); INDRI; and PROPITHECUS (sifakas). The family is distributed in Madagascar.


Suicides, Medically Assisted
Assisted Suicide
Suicide, Medically Assisted
Medically Assisted Suicides
Suicide, Assisted
Death, Assisted
Medically Assisted Suicide
Physician-Assisted Suicide

Provision (by a physician or other health professional, or by a family member or friend) of support and/or means that gives a patient the power to terminate his or her own life. (from APA, Thesaurus of Psychological Index Terms, 8th ed).


Fats, Unsaturated
Oils, Unsaturated
Unsaturated Oils
Unsaturated Fats

Fats containing one or more double bonds, as from oleic acid, an unsaturated fatty acid.


Myocardial Scintigraphy
Scintigraphy, Myocardial
Myocardial Perfusion Imaging

Imaging blood flow to the MYOCARDIUM by following the distribution of radioactively labeled tracers injected into the blood stream.


Burdock Plant
Gobou
Arctium lappa
Burdock
Arctium
Gobo
Arctium minus
Burdock, Lesser
Burdock, Greater

A plant genus of the family ASTERACEAE. Arctiin (LIGNANS) is in the seed.


A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.


PTS1 Peptide
Peroxisomal Targeting Signals
PTS2 Peptide
Peroxisomal Targeting Signal 2
Peroxisome Targeting Signal 1
Peroxisome Targeting Signal 2
Peroxisomal Targeting Signal 1
Peroxisome Targeting Signals

A C-terminal tripeptide sequence that occurs in proteins targeted to peroxisomes and characterized by (SERINE or ALANINE or CYSTEINE)-(LYSINE or ARGININE or HISTIDINE)-(LEUCINE or ALANINE) that occurs primarily in peroxisome matrix proteins. SERINE-LYSINE-LEUCINE(SKL)is the most common sequence.


Epidermal Growth Factor Receptor Family Proteins

Transforming Growth Factor alpha Receptor

Receptors, Epidermal Growth Factor-Urogastrone

Epidermal Growth Factor Receptor Protein-Tyrosine Kinase

Receptor, Transforming-Growth Factor alpha

A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS.


IMC C225
IMC-C225
Erbitux
Cetuximab
MAb C225
C225

A chimeric monoclonal antibody that functions as an ANTINEOPLASTIC AGENT through its binding to the EPIDERMAL GROWTH FACTOR RECEPTOR, where it prevents the binding and signaling action of cell growth and survival factors.


A genus of BROWN ALGAE, in the family Alariaceae, native to Japan, Korea, and China. The edible SEAWEED Undaria pinnatifida is also called wakame.


DPLPE
D-Pen2, D-Pen5-Enkephalin
DPDPE(SH)2
Bis-Penicillamine-Enkephalin
DPDPE
D-Penicillamine (2,5)-Enkephalin
Enkephalin, D-Penicillamine (2,5)-
Enkephalin, Penicillamine (2,5)-
Enkephalin, Pen(2,5)-
D-Pen2, L-Pen5-Enkephalin
Bis-Pen-Enkephalin

A disulfide opioid pentapeptide that selectively binds to the DELTA OPIOID RECEPTOR. It possesses antinociceptive activity.


Wholistic Medicine
Medicine, Wholistic
Holistic Medicine
Medicine, Holistic
Wholistic Health
Holistic Therapies
Wholistic Therapies
Wholistic Health Care
Holistic Health

Health as viewed from the perspective that humans function as complete, integrated units rather than as aggregates of separate parts.


Clinical Laboratory Scientists
Medical Laboratory Scientists
Medical Technologists
Clinical Laboratory Technicians
Medical Laboratory Technicians
Medical Laboratory Personnel
Clinical Laboratory Personnel
Medical Laboratory Assistants

Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.


An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. It requires the presence of more than two amino-acid residues in the substrate for activity. This enzyme was previously listed as EC 3.2.2.18.


18th Cent. History of Medicine
History, Eighteenth Century
Medicine, 18th Cent.
18th Cent. History (Medicine)
History of Medicine, 18th Cent.
18th Century History
Medical History, 18th Cent.
18th Cent. Medicine
History, 18th Century
Historical Events, 18th Century

Events of lasting impact or importance occurring in the 18th century.


Surgical Adhesions
Surgery-Induced Tissue Adhesions
Adhesions, Tissue
Tissue Adhesions

Pathological processes consisting of the union of the opposing surfaces of a wound.


Nuclear Magnetic Resonance, Heteronuclear

Heteronuclear Nuclear Magnetic Resonance

Nuclear Magnetic Resonance, Biomolecular

NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.


Leukotriene C4
Leukotrienes C
Leukotriene C-4
Leukotriene C-1
Leukotriene C
Leukotriene C1
LTC4

The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)


TAA Health Coverage Improvement Act of 2009

Medicare and Medicaid Health Information Technology for Economic and Clinical Health Act

Health Insurance Assistance for the Unemployed Act of 2009

Public Law No: 111-5, enacted February 2009, makes supplemental appropriations for job preservation and creation, infrastructure investment, energy efficiency and science, assistance to the unemployed, and State and local fiscal stabilization, for fiscal year ending September 30, 2009.


2,6 Dichloroindophenol
2,6-Dichloroindophenol
2,6-Dichlorophenolindophenol
Tillmans Reagent
Tillmans' Reagent
Dichlorophenol Indophenol
Sodium 2,6-Dichloroindophenol
2,6-Dichlorobenzenoneindophenol Dye
Dichlorophenolindophenol

A dye used as a reagent in the determination of vitamin C.


Critical Incident Technic
Task Performance and Analysis
Task Performance
Task Performance, Analysis
Critical Incident Technique

The detailed examination of observable activity or behavior associated with the execution or completion of a required function or unit of work.


IFN-alpha5
Interferon alpha-7
Interferon, Leukocyte
Interferon Alfa
Interferon alpha-J
LeIF J
LeIF I
Interferon alpha-88
alpha-Interferon
Interferon, alpha
Interferon alpha-T
Interferon alpha-4
Interferon alpha5
Interferon alpha-5
Interferon-alpha
Interferon alpha-1
Interferon alpha-17
Interferon alpha4
IFN-alpha D
Interferon, Lymphoblastoid
Interferon, Lymphoblast
Leif D

One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.


Immunotoxin that consists of anti-CD22 (CD22 ANTIGEN) humanized monoclonal antibody covalently linked to the antineoplastic antibiotic CALICHEAMICIN. It is used for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (LEUKEMIA, ACUTE LYMPHOBLASTIC).


Metallic Nanoparticles
Metal Nanocrystals
Metal Nanoparticles
Metallic Nanocrystals

Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.


Stevens Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

Toxic Epidermal Necrolysis Stevens Johnson Syndrome Spectrum

Mycoplasma-Induced Stevens Johnson Syndrome

Scalded Skin Syndrome, Nonstaphylococcal

Toxic Epidermal Necrolysis Stevens-Johnson Syndrome Spectrum

An exfoliative disease of skin seen primarily in adults and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure.


Colonoscopic Surgical Procedures
Colonoscopy
Surgical Procedures, Colonoscopic
Surgery, Colonoscopic
Colonoscopic Surgery

Endoscopic examination, therapy or surgery of the luminal surface of the colon.


Isobutyric Acids
2-Methylpropionic Acids
Isobutyrates
Dimethylacetic Acids

Aliphatic acids that contain four carbons in a branched-chain configuration. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-carboxypropane structure.


Duck Hepatitis A Virus 3
Hepatitis Virus, Duck
Duck Hepatitis A Virus
Duck Hepatitis A Virus 2
Duck Hepatitis A Virus 1
Duck Hepatitis Virus
Duck Hepatitis Virus 1
Avihepatovirus A
Duck Hepatitis Virus 3

Unassigned species, in the family PICORNAVIRIDAE, causing high mortality in ducklings 3 days to 3 weeks old.


46,XY Sex Reversal, Partial or Complete, NR5A1-Related

46,XY Gonadal Dysgenesis, Complete or Partial, With or Without Adrenal Failure

Sex Reversal, XY, With Or Without Adrenal Failure

Congenital conditions in individuals with a male karyotype, in which the development of the gonadal or anatomical sex is atypical.


Recombinant Chimeric Proteins
Chimeric Proteins, Recombinant
Fusion Proteins, Recombinant
Recombinant Hybrid Proteins
Recombinant Fusion Proteins
Hybrid Proteins, Recombinant

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.


Oil and Gas Industry
Petroleum Industry
Industry, Natural Gas
Natural Gas Industry
Gas and Oil Industry
Crude Oil Industry

INDUSTRY concerned with the extraction, processing, distribution, marketing and storage of PETROLEUM and NATURAL GAS.


Nova Scotia Niemann-Pick Disease (Type D)

Nova Scotia (Type D) Form of Niemann-Pick Disease

Niemann-Pick Disease with Cholesterol Esterification Block

Niemann-Pick Disease, Chronic Neuronopathic Form

Niemann-Pick Disease without Sphingomyelinase Deficiency

Neurovisceral Storage Disease with Vertical Supranuclear Ophthalmoplegia

Niemann-Pick disease, Subacute Juvenile Form

An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes  a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.


Calcinosis, Raynaud's phenomenon, Esophageal dismobility, Sclerodactyly, Telangiectasia Syndrome

A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.


Chromolaena odorata
Chromolaena
Eupatorium odoratum

A plant genus of the family ASTERACEAE. The common name of thoroughwort is also used for other plants including EUPATORIUM; CHROMOLAENA, Hebeclinium and Koanophyllon. Eupolin is the aqueous extract of the leaves.


v-fos Genes
fos Genes
c-fos Proto-Oncogenes
v-fos Oncogenes
Genes, fos
c-fos Genes

Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene protein c-fos codes for a nuclear protein which is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-31 on the long arm of chromosome 14.


Choleragen
Cholera Toxin
Cholera Toxin B Subunit
Procholeragenoid
Cholera Exotoxin
Cholera Toxin Protomer B
Cholera Toxin A Subunit
Choleragenoid
Cholera Enterotoxin CT
Cholera Toxin Protomer A

Detoxified aggregate of cholera toxin formed by heat treatment of purified cholera toxin.


Decapodiformes Sepiidae Squid Illex Cuttlefish Todarodes

A genus that includes the Japanese flying squid.


Salivary Gland Viruses
Herpesvirus 5, Human
Cytomegalovirus
Human Herpesvirus 5
HHV 5
Herpesvirus 5 (beta), Human


Compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups. Members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains. They are possibly involved in the etiology of schizophrenia.


Microhomology-Mediated End Joining Repair

The repair of DOUBLE-STRAND DNA BREAKS by rejoining the broken ends of DNA to each other directly.


Cranial Fontanelles
Anterior Fontanelle
Sphenoidal Fontanelle
Posterior Fontanelle
Anterior Fontanel
Sphenoidal Fontanel
Mastoid Fontanelle
Cranial Fontanel
Posterior Fontanel
Mastoid Fontanel

Any of six membrane-covered openings between the CRANIAL SUTURES in the incompletely ossified skull of the fetus or newborn infant. The fontanelles normally close sometime after birth.


A member of the AGARICALES known for edible MUSHROOMS.


ETASU
Risk Evaluation and Mitigation
Elements to Assure Safe Use

Strategies required by the US Food and Drug Administration (FDA) Amendments Act of 2007 when a question exists as to whether the benefits of a drug outweigh its risks. These constitute a safety plan with several potential components, including a medication guide, a communication plan, elements to ensure safe use and an implementation system to help guide the prescribers, pharmacists and patients.


Bay Leaf
Bay Laurel
Laurus
Laurus nobilis

Laurus nobilis L. leaves are known for use in SPICES.


A colloidal, hydrated aluminum silicate that swells 12 times its dry size when added to water.


National Health Planning and Resources Development Act of 1974

Planning for needed health and/or welfare services and facilities.


Immunological Contraceptive Techniques
Immunological Fertility Control
Immunological Contraceptive Technics
Immunocontraceptive Techniques
Immunologic Contraception
Fertility Control, Immunological
Contraception, Immunological
Immunocontraception
Contraception, Immunologic

Contraceptive methods based on immunological processes and techniques, such as the use of CONTRACEPTIVE VACCINES.


Teratoma, Immature
Teratoma, Mature
Teratoma, Benign
Dysembryoma
Teratoma, Cystic
Teratoid Tumor
Teratoma
Teratoma, Malignant

A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)


Abortifacient Agents
Contraceptive Agents, Postconception
Abortifacient Effects
Abortifacients
Abortifacient Effect

Chemical substances that interrupt pregnancy after implantation.


Diethyldithiocarbamic Acid
Imuthiol
Ditiocarb, Sodium Salt, Trihydrate
Ditiocarb, Bismuth Salt
Ditiocarb, Lead Salt
Thiocarb
Ditiocarb, Sodium Salt
Diethyldithiocarbamate
Zinc Diethyldithiocarbamate
Ditiocarb, Zinc Salt
Ditiocarb, Potassium Salt
Diethylcarbamodithioic Acid
Ditiocarb
Ditiocarb, Tin(4+) Salt
Dithiocarb
Ditiocarb Sodium
Sodium Diethyldithiocarbamate
Ditiocarb, Ammonium Salt

A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.


Septal Occluder Device
CardioSeal Septal Occluder
Amplatzer Occluder
Helex Septal Occluder
Gore-Helex Septal Occluder
Amplatzer Occluder Device
Septal Occluder
Amplatzer Septal Occluder
Amplatzer Septal Occluder Device
CardioSeal Occluder

A CATHETER-delivered implant used for closing abnormal holes in the cardiovascular system, especially HEART SEPTAL DEFECTS; or passageways intentionally made during cardiovascular surgical procedures.


Maned Wolf
Canidae
Chrysocyon brachyurus

In spite of its common name, this is more closely related to the South American FOXES than WOLVES.


Arachnoid Diverticula
Intracranial Arachnoid Cysts
Arachnoid Cysts, Intracranial
Leptomeningeal Cysts
Arachnoid Cysts

Intracranial or spinal cavities containing a cerebrospinal-like fluid, the wall of which is composed of arachnoidal cells. They are most often developmental or related to trauma. Intracranial arachnoid cysts usually occur adjacent to arachnoidal cistern and may present with HYDROCEPHALUS; HEADACHE; SEIZURES; and focal neurologic signs. (From Joynt, Clinical Neurology, 1994, Ch44, pp105-115)


Ectodysplasin
Ectodysplasin A, Isoform 1
Ectodysplasin A2
Ectodysplasin-A
Ectodysplasins
Ectodysplasin A1
Ectodysplasin A, Isoform 2

An ectodysplasin isoform with specificity for the XEDAR RECEPTOR.


Cnidarian Venom
Portuguese Man-of-War Venom
Cnidarian Venoms
Nematocyst Venoms
Chironex Venoms
Jellyfish Venoms
Jellyfish Venom
Sea Anemone Venom
Sea Anemone Venoms
Chironex Venom

Venoms from jellyfish; CORALS; SEA ANEMONES; etc. They contain hemo-, cardio-, dermo- , and neuro-toxic substances and probably ENZYMES. They include palytoxin, sarcophine, and anthopleurine.


Seizures, Simple Partial, Special Sensory Symptoms

Simple Partial Seizures, Special Sensory Symptoms

A disorder characterized by recurrent focal onset seizures which have sensory (i.e., olfactory, visual, tactile, gustatory, or auditory) manifestations. Partial seizures that feature alterations of consciousness are referred to as complex partial seizures (EPILEPSY, COMPLEX PARTIAL).


Geographic Factors
Factors, Geographic
Geography, Human
Human Geography
Geography
Geographic Factor
Factor, Geographic

The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)


Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy, and Skeletal Abnormalities

Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy and Skeletal Abnormalities

GRANULOCYTE morphologic changes similar to the cells in familial Pelger-Huet anomoly. Granulocytes have abnormal bilobular morphology with hypercondensation due to drug therapy or secondary to diseases such as MYELODYSPLASTIC SYNDROMES and ACUTE MYELOID LEUKEMIA.