Uptake Inhibitors, Gamma-Aminobutyric Acid

Gamma-Aminobutyric Acid Plasma Membrane Transport Inhibitors

Compounds that suppress or block the plasma membrane transport of GAMMA-AMINOBUTYRIC ACID by GABA PLASMA MEMBRANE TRANSPORT PROTEINS.


Signaling Lymphocytic Activation Molecule Associated Protein

A signal transducing adaptor protein that contains a single SH2 DOMAIN and is essential for the regulation of SLAM FAMILY RECEPTORS in the immune response. Mutations in the SLAM-associated protein gene have been identified in cases of X-LINKED LYMPHOPROLIFERATIVE DISEASE.


Neutrophil Infiltration
Neutrophil Recruitment

The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.


Aortic Aneurysm, Abdominal
Aneurysm, Abdominal Aortic
Abdominal Aortic Aneurysm

An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.


Subcellular structures found in nerve cell bodies and DENDRITES. They consist of granular endoplasmic reticulum (ENDOPLASMIC RETICULUM, ROUGH) and RIBOSOMES.


The myrtle plant family of the order Myrtales. It includes several aromatic medicinal plants such as EUCALYPTUS.


Fluorescence Polarization Immunoassay
Immunoassay, Fluorescence Polarization
Polarization Fluoroimmunoassay

Fluoroimmunoassay where detection of the hapten-antibody reaction is based on measurement of the increased polarization of fluorescence-labeled hapten when it is combined with antibody. The assay is very useful for the measurement of small haptenic antigens such as drugs at low concentrations.


Trichosurus
Trichosurus vulpecula
Possums, Brush-Tailed

A genus of brush-tailed possums found chiefly in Australia and New Zealand. Secretions from their ANAL GLAND function both in defense and demarcating territory.


Dental Microabrasion
Enamel Microabrasions
Enamel Microabrasion
Dental Microabrasions
Microabrasion, Dental
Microabrasions, Enamel
Microabrasion, Enamel
Microabrasions, Dental

Mechanical removal of a small amount of tooth structure (not more than a few tenths of a millimeter in depth) to eliminate superficial enamel discoloration defects not successfully removed by bleaching techniques. A common abrasive is a mixture of pumice and hydrochloric acid.


Lumisterol
Ergosterol
Pro-Vitamin D2
Provitamin D 2

A steroid occurring in FUNGI. Irradiation with ULTRAVIOLET RAYS results in formation of ERGOCALCIFEROL (vitamin D2).


Lobsters, Spiny
Panulirus
Spiny Lobsters
Palinuridae

A family of marine CRUSTACEA, in the order DECAPODA, comprising the clawless lobsters. They are found in tropical and subtropical waters and characterized by short spines along the length of the tail and body.


Injuries resulting in hemorrhage, usually manifested in the skin.


Brucella melitensis biovar canis
Brucella canis

A species of gram-negative bacteria infecting DOGS, the natural hosts, and causing canine BRUCELLOSIS. It can also cause a mild infection in humans.


Contraception Behavior
Contraceptive Method Switching
Contraceptive Usage
Contraceptive Behavior

Behavior patterns of those practicing CONTRACEPTION.


A plant genus of the family LAMIACEAE that contains tilianin, agastanol, and agastaquinone (a cytotoxic diterpenoid quinone).


Cyclic AMP-Responsive DNA-Binding Protein

DNA-Binding Protein, Cyclic AMP-Responsive

Cyclic AMP Response Element-Binding Protein

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.


Susceptibility, Genetic
Genetic Predisposition to Disease
Genetic Susceptibility
Genetic Predisposition
Predisposition, Genetic

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.


Orchid Family
Orchidaceae
Oncidium
Cypripedium
Phalaenopsis

A plant family of the order Asparagales. All members of the orchid family have the same bilaterally symmetrical flower structure, with three sepals, but the flowers vary greatly in color and shape.


Trifluoridine
5-Trifluoromethyl-2'-deoxyuridine
Viromidin
Virophta
Trifluridine
Viroptic
Triflumann
TFT Ophtiole
2'-deoxy-5-(trifluoromethyl)uridine
Trifluorothymidine

An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)


A reagent used for the determination of iron.


An inborn error of metabolism marked by a defect in the lysosomal isoform of ALPHA-MANNOSIDASE activity that results in lysosomal accumulation of mannose-rich intermediate metabolites. Virtually all patients have psychomotor retardation, facial coarsening, and some degree of dysostosis multiplex. It is thought to be an autosomal recessive disorder.


Myeloid Sarcoma
Sarcoma, Granulocytic
Extramedullary Myeloid Cell Tumor
Sarcoma, Myeloid
Myeloid Cell Tumor, Extramedullary
Chloroma

An extramedullary tumor of immature MYELOID CELLS or MYELOBLASTS. Granulocytic sarcoma usually occurs with or follows the onset of ACUTE MYELOID LEUKEMIA.


Ghee
Butter Oil
Clarified Butter
Anhydrous Butterfat

The clarified portion of milk, cream, or butter obtained by the removal of the nonfat constituents. (from Dictionary of Food Ingredients, 4th ed., 2001)


A type VI intermediate filament protein expressed mostly in nerve cells where it is associated with the survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.


Care, Comprehensive Dental
Comprehensive Dental Care
Dental Care, Comprehensive

Providing for the full range of dental health services for diagnosis, treatment, follow-up, and rehabilitation of patients.


Nuclear Matrix
Nuclear Scaffold
Nucleoskeleton

The residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior. (Advan. Enzyme Regul. 2002; 42:39-52)


The application of dental knowledge to questions of law.


Myocardial Reperfusion
Coronary Reperfusion
Reperfusion, Myocardial

Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.


Gum Karaya
Karaya Gum
Tragacanth, Indian

Polysaccharide gum from Sterculia urens (STERCULIA). It is used as a suspending or stabilizing agent in foods, cosmetics and pharmaceuticals; a bulk-forming laxative; a surgical lubricant and adhesive; and in the treatment of skin ulcers.


Bony cavity that holds the eyeball and its associated tissues and appendages.


Multicellular Spheroids
Spheroids, Cellular

Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)


Pulegium vulgare
Mentha pulegium
European Pennyroyal
Pennyroyal, European

A plant genus of the family LAMIACEAE that contains pulegone. Do not confuse with 'American false pennyroyal' (HEDEOMA).


Oncogene Product p55(v-myc)
myc Oncogene Protein p55
myc Oncogene Product p55
p55 v-myc
v-myc Protein p55
Oncogene Protein p55(v-myc)
p55(v-myc)

Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies.


Embolism, Paradoxical
Crossed Embolism
Paradoxical Embolism

Blockage of an artery due to passage of a clot (THROMBUS) from a systemic vein to a systemic artery without its passing through the lung which acts as a filter to remove blood clots from entering the arterial circulation. Paradoxical embolism occurs when there is a defect that allows a clot to cross directly from the right to the left side of the heart as in the cases of ATRIAL SEPTAL DEFECTS or open FORAMEN OVALE. Once in the arterial circulation, a clot can travel to the brain, block an artery, and cause a STROKE.


TCF4 Transcription Factor
TCF-4 Transcription Factor
Transcription Factor 4
TCF-4 Protein

A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.


Parish Nursing
Church Nursing
Faith Community Nursing

A nursing specialty involving programs designed to bring wholeness and healing to a particular faith community through addressing the health needs of body, mind, and spirit. They are coordinated by registered NURSES and may involve HEALTH EDUCATION and counseling, facilitation, referral, PATIENT ADVOCACY, and health care plan interpretation, as influenced and defined by the unique needs of the congregation.


Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.


A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.


Peptide Synthetases
Peptide Synthases
Acid-Amino-Acid Ligases

Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.


A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.


Packed Red-Cell Volume
Hematocrit
Erythrocyte Volume, Packed

The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.


A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)


Hereditary Breast and Ovarian Cancer Syndrome

Autosomal dominant HEREDITARY CANCER SYNDROME in which a mutation most often in either BRCA1 or BRCA2 is associated with a significantly increased risk for breast and ovarian cancers.


Food Labeling
Labeling, Food
Nutrition Labeling
Product Labeling, Food
Food Labelling

Use of written, printed, or graphic materials upon or accompanying a food or its container or wrapper. The concept includes ingredients, NUTRITIONAL VALUE, directions, warnings, and other relevant information.


9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.


A vesicular transport protein that was originally characterized as an inositol polyphosphate binding protein. Synaptotagmin II helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.


5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.


Myeloid Ecotropic Viral Integration Site 1 Protein

A TALE-type homeodomain protein and transcription factor that functions as a regulator of PAX6 PROTEIN expression and as an activator of PLATELET FACTOR 4 gene expression. It is essential for hematopoiesis, differentiation of MEGAKARYOCYTES, and vascular patterning. It may also have a role in the induction of myeloid leukemias.


United States National Institute of Mental Health

National Institute of Mental Health (U.S.)

A component of the NATIONAL INSTITUTES OF HEALTH concerned with research, overall planning, promoting, and administering mental health programs and research. It was established in 1949.


Neurologic Symptoms
Neurologic Signs
Neurologic Manifestation
Neurologic Dysfunction
Focal Neurologic Deficits
Neurologic Findings
Neurologic Deficits
Neurologic Signs and Symptoms
Manifestations, Neurologic
Neurologic Manifestations
Neurological Manifestations
Manifestations, Neurological

Clinical signs and symptoms caused by nervous system injury or dysfunction.


Enterotoxin
Enterotoxins
Staphylococcal Enterotoxins

Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.


A genus of pearl oysters in the family Pteriidae, class BIVALVIA. Both cultured and natural pearls are obtained from species in the genus. They are distinct from the distantly related, edible true oysters of the family OSTREIDAE.


5-HT3 Antagonist
5-HT3 Antagonists
Serotonin 5-HT3 Receptor Antagonists

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.


Heterocyclic N-Oxides
Cyclic N Oxides
Cyclic N-Oxides

Heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.


Secondary Referral Center
Secondary Care Centers
Secondary Referral Hospital
Secondary Care Facility

A healthcare facility equipped to provide all but the most specialized forms of care, surgery, and diagnostic techniques.


Organic derivatives of thiocyanic acid which contain the general formula R-SCN.


The single family of PRIMATES in the infraorder TARSII, suborder HAPLORHINI. It is comprised of one genus, Tarsius, that inhabits southern Sumatra, Borneo, Sulawesi, and the Philippines.


Job Site
Work Location
Workplace
Work Place
Worksite
Work-Site

Place or physical location of work or employment.


Tooth, Natal
Teeth Present At Birth
Natal Teeth

Predeciduous teeth present at birth. They may be well formed and normal or may represent hornified epithelial structures without roots. They are found on the gingivae over the crest of the ridge and arise from accessory buds of the dental lamina ahead of the deciduous buds or from buds of the accessory dental lamina. (From Jablonski, Dictionary of Dentistry, 1992)


Flavotoxin A
Bongkrekate
Bongkrekic Acid

An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.


Pain, Menstrual
Dysmenorrhea
Menstruation, Painful


Early Growth Response Protein 2
EGR2 Transcription Factor
Krox20 Protein
Krox-20 Transcription Factor

An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.


Revolutionary War
American Revolution
American Revolution, 1775-1783
American War of Independence

Armed conflict that resulted in separation of American colonies from Britain and established the United States of America.


Kidney Transplantation
Renal Transplantation
Transplantation, Kidney
Transplantation, Renal
Grafting, Kidney

The transference of a kidney from one human or animal to another.


Invasiveness, Neoplasm
Neoplasm Invasiveness
Neoplasm Invasion

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.


An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.


PHD Finger Domain
PHD Domains
PHD Zinc Finger
PHD Fingers
PHD Motif
PHD Motifs
PHD Zinc Fingers

Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.


Acetothiokinase
Acetyl Activating Enzyme
Acetyl CoA Synthetase
Acetate-CoA Ligase
Acetyl Coenzyme A Synthetase
Acetate Thiokinase

An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.


Collagenase-3
Matrix Metalloproteinase-13
MMP-13 Metalloproteinase
Collagenase 3
Matrix Metalloproteinase 13
MMP13 Metalloproteinase

A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellular matrix found in skeletal tissues. It is synthesized as an inactive precursor that is activated by the proteolytic cleavage of its N-terminal propeptide.


Transcription Factor E2F-4
E2F4 Transcription Factor
E2F Transcription Factor 4 Protein
E2F-4 Protein
E2F-4 Transcription Factor

An E2F transcription factor that represses GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F4 recruits chromatin remodeling factors indirectly to target gene PROMOTER REGIONS through RETINOBLASTOMA LIKE PROTEIN P130 and RETINOBLASTOMA LIKE PROTEIN P107.


Interleukin-1 Receptor Accessory Protein

A protein that takes part in the formation of active interleukin-1 receptor complex. It binds specifically to INTERLEUKIN-1 and the INTERLEUKIN-1 RECEPTOR TYPE I at the cell surface to form a heterotrimeric complex that brings its cytoplasmic domain into contact with the cytoplasm domain of the TYPE-I INTERLEUKIN-1 RECEPTOR. Activation of intracellular signal transduction pathways from the receptor is believed to be driven by this form of cytoplasmic interaction.


Tumor Necrosis Factor Receptor Superfamily, Member 11b

Follicular Dendritic Cell-Derived Receptor-1

Receptors, Tumor Necrosis Factor, Member 11b

A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.


Congenital, complete or partial fusion of the TARSAL BONES of the foot. PES PLANUS is usually a feature.


Cetrimonium Compounds
Cetrimides
Cetyltrimethylammonium Compounds

Cetyltrimethylammonium compounds that have cationic detergent, antiseptic, and disinfectant activities. They are used in pharmaceuticals, foods, and cosmetics as preservatives; on skin, mucous membranes, etc., as antiseptics or cleansers, and also as emulsifiers. These compounds are toxic when used orally due to neuromuscular blockade.


Pyrrolamidol
Palfium
Dextromoramide Tartrate
D-Moramide
Dextromoramide

An opioid analgesic structurally related to METHADONE and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)


Coloring Agents, Food
Food Colorants
Food Coloring Agents

Natural or synthetic dyes used as coloring agents in processed foods.


Parnate
Tranylcypromine
Transamine
Jatrosom
Tranylcypromine Sulfate
trans-2-Phenylcyclopropylamine

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)


Urea Peroxide
Urea Hydrogen Peroxide
Perhydrol Urea
Carbamide Peroxide

A urea peroxide compound that is commonly used in tooth whitening agents; topical anti-infective agents, and earwax remover.


Thyrolingual Cyst
Thyroglossal Duct Cyst
Thyroglossal Cyst

A cyst in the neck caused by persistence of portions of, or by lack of closure of, the primitive thyroglossal duct. (Dorland, 27th ed)


Megakaryocytic Leukemia, Acute
Megakaryoblastic Leukemia, Acute
Leukemia, Megakaryocytic, Acute
Myeloid Leukemia, Acute, M7
Leukemia, Megakaryocytic
Leukemia, Myeloid, Acute, M7
Megakaryocytic Leukemia
Leukemia, Megakaryoblastic, Acute

An acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. MYELOFIBROSIS or increased bone marrow RETICULIN is common.


Coordinate set of non-specific behavioral responses to non-psychiatric illness. These may include loss of APPETITE or LIBIDO; disinterest in ACTIVITIES OF DAILY LIVING; or withdrawal from social interaction.


Killer Cell Immunoglobulin-like Receptor 2DL2

A KIR receptor that has specificity for HLA-C ANTIGENS. It is an inhibitory receptor that contains D1 and D2 extracellular immunoglobulin-like domains and a long cytoplasmic tail. It is similar in structure and function to the KIR2DL1 RECEPTORS and the KIR2DL3 RECEPTORS.


Cytochrome P450 Family 8
CYP8 Family
CYP8 Enzymes

A cytochrome P450 enzyme family whose members include prostacyclin synthase and STEROID 12-ALPHA-HYDROXYLASE, which function in the biosynthesis of BILE ACIDS.


Inducible Nitric Oxide Synthase
INOS Enzyme
NOS-II
Nitric Oxide Synthase, Type II
Nitric Oxide Synthase II
Nitric Oxide Synthase Type II
Inducible NOS Protein

A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.


Gabapentin
PMS-Gabapentin
Neurontin
Novo-Gabapentin
Convalis
Gabapentin-Ratiopharm
Gabapentin Hexal
Gabapentin Stada
1-(Aminomethyl)cyclohexaneacetic Acid
Apo-Gabapentin

A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.


Ribonucleotide Reductase
Ribonucleotide Reductases


Ion-Selective Electrodes
Ion-Sensitive Electrodes
Electrodes, Ion-Selective

Electrodes which can be used to measure the concentration of particular ions in cells, tissues, or solutions.


Oceans and Seas
Seas
Oceans
Seas and Oceans

A great expanse of continuous bodies of salt water which together cover more than 70 percent of the earth's surface. Seas may be partially or entirely enclosed by land, and are smaller than the five oceans (Atlantic, Pacific, Indian, Arctic, and Antarctic).


A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.


A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.


Needle Sharing
Syringe Sharing
Needle-Sharing
Needlesharing

Usage of a single needle among two or more people for injecting drugs. Needle sharing is a high-risk behavior for contracting infectious disease.


Binding, Competitive
Competitive Binding

The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.


Pharmaceutic Chemistry
Chemistry, Pharmaceutic
Chemistry, Pharmaceutical
Medicinal Chemistry
Pharmaceutical Chemistry

Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.


ATP Binding Cassette Transporter, Sub-Family D

ATP Binding Cassette Transporter, Subfamily D

A sub-family of ATP-binding cassette transporters that localize to the membranes of PEROXISOMES; ENDOPLASMIC RETICULUM; and LYSOSOMES. Members contain a transmembrane domain in their N-terminal half and generally function as homodimers in the transport of LIPIDS; BILE ACIDS; and VITAMIN B12. Mutations in some ABCD transporter genes are associated with PEROXISOMAL DISORDERS.


Renal Absorption
Tubule Reabsorption
Renal Reabsorption

The reuptake of water, ELECTROLYTES, and other substances by the KIDNEY to the blood supply.


A monoterpene and cyclohexanol derivative that is the major component of EUCALYPTUS OIL. It is used in mouthwash, insect repellent, and as a cough suppressant, and also is widely used as a flavoring agent and solvent. It has antimicrobial properties.


tax Protein
p40(tax)
Trans-Activator Protein p40(lor)
Trans-Activator Protein p40x
Gene Product, tax
p40 tax
Transforming Antigen p40x
tax Gene Products
Trans-Activator Protein pX
Transactivator Protein p40(x)
Trans-Activator Protein p40(tax)
Transactivator p40(tax)
Gene Products, tax
Trans-Activator Protein p40(x)

Transcriptional trans-acting proteins of the promoter elements found in the long terminal repeats (LTR) of HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. The tax (trans-activator x; x is undefined) proteins act by binding to enhancer elements in the LTR.


Radiation Syndrome
Radiation Injuries
Radiation Sickness
Injuries, Radiation

Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.


Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.


Association, Individual Practice
IPA (Individual Practice Association)
IPA (Independent Practice Association)
Practice Association, Individual
Independent Practice Associations
Practice Association, Independent
Individual Practice Associations
Association, Independent Practice

A partnership, corporation, association, or other legal entity that enters into an arrangement for the provision of services with persons who are licensed to practice medicine, osteopathy, and dentistry, and with other care personnel. Under an IPA arrangement, licensed professional persons provide services through the entity in accordance with a mutually accepted compensation arrangement, while retaining their private practices. Services under the IPA are marketed through a prepaid health plan. (From Facts on File Dictionary of Health Care Management, 1988)


Rats, Inbred Fisher 344
Rats, F344
Fischer Rats
Rats, Inbred F344
Rats, Inbred Fischer 344
Rats, Inbred CDF

An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes.


Specialties, Surgical
Surgical Specialties

Various branches of surgical practice limited to specialized areas.


Glycerol Trioleate
Trioleyl Glycerol
Trioleoylglycerol
Trioleate-Glycerin
Trielaidin
Triolein

(Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.


Polydeoxyribonucleotides made up of deoxyadenine nucleotides and thymine nucleotides. Present in DNA preparations isolated from crab species. Synthetic preparations have been used extensively in the study of DNA.


Carotid Artery, Internal, Dissection
Carotid Artery Dissection, Internal
Dissection, Internal Carotid Artery
Internal Carotid Artery Dissection

The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.


Deoxyribonucleic acid that makes up the genetic material of viruses.


Lymphocyte Antigen 96
LY96 Protein
MD-2 Protein

A secreted protein that associates with TOLL-LIKE RECEPTOR 4 and is essential for receptor recognition of LIPOPOLYSACCHARIDES.


A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE.


7-Hydroxycoumarins Skimmetin Hydrangin Umbelliferones

7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.


Musculoskeletal Diseases
Orthopedic Disorders

Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.


Cardiac Arrhythmias
Cardiac Dysrhythmia
Arrythmia
Arrhythmias, Cardiac
Cardiac Arrhythmia
Arrhythmia

Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.


Community Health Nursing
Nursing, Community Health

General and comprehensive nursing practice directed to individuals, families, or groups as it relates to and contributes to the health of a population or community. This is not an official program of a Public Health Department.


Moraxella bovis
Moraxella (Moraxella) bovis

A species of gram-negative, aerobic bacteria that is most frequently isolated from bovine eyes in cases of infectious keratoconjunctivitis (KERATOCONJUNCTIVITIS, INFECTIOUS), but also occurs in unaffected eyes and the nasal cavity of cattle.


Flame Retardants
Fireproofing Agents
Fire Retardants

Materials applied to fabrics, bedding, furniture, plastics, etc. to retard their burning; many may leach out and cause allergies or other harm.


HIV-1 Fusion Coreceptor Antagonists
Chemokine Co-receptor 5 Antagonists
CC Chemokine Receptor 5 Blockers
CCR5 Receptor Antagonists
CCR5 Receptor Blockers
CC Chemokine Receptor 5 Antagonists

Compounds and drugs that inhibit or block the activity of CCR5 RECEPTORS.


An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.


Auditory Dysfunction, Central
Central Auditory Diseases
Auditory Cortex Disorder
Auditory Pathway Disorders, Central
Central Auditory Pathway Disorders
Auditory Diseases, Central

Disorders of hearing or auditory perception due to pathological processes of the AUDITORY PATHWAYS in the CENTRAL NERVOUS SYSTEM. These include CENTRAL HEARING LOSS and AUDITORY PERCEPTUAL DISORDERS.


The second largest of the TARSAL BONES. It articulates with the TIBIA and FIBULA to form the ANKLE JOINT.


Arteriovenous Anastomosis
Arteriovenous Anastomoses

A vessel that directly interconnects an artery and a vein, and that acts as a shunt to bypass the CAPILLARY BEDS. Not to be confused with SURGICAL ANASTOMOSIS or ARTERIOVENOUS FISTULA.


A thymidine derivative and antiviral agent that inhibits DNA synthesis by HEPATITIS B VIRUS and is used for the treatment of CHRONIC HEPATITIS B.


Dental Infection Control
Infection Control, Dental

Efforts to prevent and control the spread of infections within dental health facilities or those involving provision of dental care.


A HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*07 alleles.


Chemical Water Pollution
Water Pollution, Chemical

Adverse effect upon bodies of water (LAKES; RIVERS; seas; groundwater etc.) caused by CHEMICAL WATER POLLUTANTS.


AT-Rich Interactive Domain 4A (RBP1-Like) Protein

A ubiquitously expressed regulatory protein that contains a retinoblastoma protein binding domain and an AT-rich interactive domain. The protein may play a role in recruiting HISTONE DEACETYLASES to the site of RETINOBLASTOMA PROTEIN-containing transcriptional repressor complexes.


Nonalcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
NAFLD
Fatty Liver, Nonalcoholic
Nonalcoholic Steatohepatitis

Fatty liver finding without excessive ALCOHOL CONSUMPTION.


Melatonin MT2 Receptor
Receptor, Melatonin, MT2
Melatonin 1b Receptor
MT2 Receptor
Mel 1b Receptor

A melatonin receptor subtype primarily found expressed in the BRAIN and RETINA.


A family of softbacked TICKS, in the subclass ACARI. Genera include ARGAS and ORNITHODOROS among others.


Abdominal Closure Techniques
Abdominal Wound Closure Techniques
Abdominal Wound Closure

Methods to repair breaks in abdominal tissues caused by trauma or to close surgical incisions during abdominal surgery.


Analgesia, Patient-Controlled
Patient-Controlled Analgesia

Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).


Eye Enucleation
Enucleation Surgery
Enucleation Technique

The surgical removal of the eyeball leaving the eye muscles and remaining orbital contents intact.


Activator Protein-1
Transcription Factor AP-1
AP-1
AP-1 Enhancer Binding Protein
AP-1 Enhancer-Binding Protein

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.


UDP-Glucose Glycogen Glucosyl Transferase

An enzyme that catalyzes the transfer of D-glucose from UDPglucose into 1,4-alpha-D-glucosyl chains. EC 2.4.1.11.


Total number of calories taken in daily whether ingested or by parenteral routes.


Bartonellaceae Infections
Infections, Bartonellaceae

Infections with bacteria of the family BARTONELLACEAE.


Dental Deposits
Deposits, Dental
Deposit, Dental
Dental Deposit
Materia Alba

Accumulations of microflora that lead to pathological plaque and calculus which cause PERIODONTAL DISEASES. It can be considered a type of BIOFILMS. It is subtly distinguished from the protective DENTAL PELLICLE.


Lung Diseases, Parasitic
Parasitic Lung Diseases
Parasitic Infections of Lung
Pulmonary Parasitic Infections

Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).


Sprue, Celiac
Celiac Sprue
Gluten Enteropathy
Sprue
Gluten-Sensitive Enteropathy
Sprue, Nontropical
Celiac Disease

A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.


ras-Related C3 Botulinum Toxin Substrate 1

A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls the development of filopodia and lamellipodia in cells and thereby influences cellular motility and adhesion. It is also involved in activation of NADPH OXIDASES. This enzyme was formerly listed as EC 3.6.1.47.


A genus of gram-positive BACTERIA in the family Gordoniaceae, isolated from soil and from sputa of patients with chest disorders. It is also used for biotransformation of natural products.


Anesthetics, Local
Anesthetics, Conduction-Blocking
Conduction-Blocking Anesthetics
Anesthetics, Topical

Anesthetic applied on a specific site of body.


Benign epidermal proliferations or tumors; some are viral in origin.


Retinocochleocerebral Vasculopathy
Susac's Syndrome
Susac Syndrome

A rare disorder consisting of microangiopathy of brain, retina, and inner ear ARTERIOLES. It is characterized by the clinical triad of encephalopathy, BRANCH RETINAL ARTERY OCCLUSION and VERTIGO/hearing loss.


Heat-Stable Antigen CD24
Nectadrin
Antigens, CD24
CD24 Antigen
CD24 Antigens

A GPI-linked cell adhesion protein originally identified as a heat stable antigen in mice. It mediates antigen-dependent activation and proliferation of B-CELLS. It is also involved in METASTASIS and is highly expressed in many NEOPLASMS.


One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair (PRONEPHROI) during development. Mesonephroi are the permanent kidneys in adult amphibians and fish. In higher vertebrates, proneprhoi and most of mesonephroi degenerate with the appearance of metanephroi. The remaining ducts become WOLFFIAN DUCTS.


Custody, Child
Child Support
Child Custody

A parent’s legal obligation to contribute to the financial care and costs of raising his or her CHILD.  Child support is generally made via court-ordered payments by a noncustodial divorced parent to the custodial parent.


Neurotic Disorders
Neuroses
Psychoneuroses

Disorders in which the symptoms are distressing to the individual and recognized by him or her as being unacceptable. Social relationships may be greatly affected but usually remain within acceptable limits. The disturbance is relatively enduring or recurrent without treatment.


HDAC2 Histone Deacetylase
Histone Deacetylase 2

A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 1; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.


Locust Tree
Wattle Tree
Acacia catechu
Acacia

A plant genus of the family FABACEAE. The gums and tanning agents obtained from Acacia are called GUM ARABIC. The common name catechu is more often used for Areca catechu (ARECA).


Radioligand Assay
Protein-Binding Radioassay
Radioreceptor Assay

Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).


Short Interspersed DNA Sequence Elements

Highly repeated sequences, 100-300 bases long, which contain RNA polymerase III promoters. The primate Alu (ALU ELEMENTS) and the rodent B1 SINEs are derived from 7SL RNA, the RNA component of the signal recognition particle. Most other SINEs are derived from tRNAs including the MIRs (mammalian-wide interspersed repeats).


Travel Medicine
Medicine, Emporiatric
Emporiatrics

The specialty devoted to the medical aspects of travel. It excludes study tours.


Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins

Soluble N-Ethylmaleimide-Sensitive Fusion Attachment Protein

SNARE binding proteins that facilitate the ATP hydrolysis-driven dissociation of the SNARE complex. They are required for the binding of N-ETHYLMALEIMIDE-SENSITIVE PROTEIN (NSF) to the SNARE complex which also stimulates the ATPASE activity of NSF. They are unrelated structurally to SNAP-25 PROTEIN.


Leukemia-Associated Cell Surface Antigen p24

27 kDa Diphtheria Toxin Receptor-Associated Protein

A subtype of tetraspanin protein that plays a role in cell adhesion, cell motility, and tumor metastasis. It functions in platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg.


IL-1 beta
Interleukin-1beta
Interleukin-1 beta
Catabolin

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.


Human T Lymphotropic Virus II
Human T-Lymphotropic Virus II
Human T-Cell Leukemia Virus II
HTLV-II
Leukemia Virus II, Human T Cell
Human T-lymphotropic virus 2
Leukemia Virus II, Human T-Cell
T Cell Leukemia Virus II, Human
T-Cell Leukemia Virus II, Human
HTLV-2
Human T Cell Leukemia Virus II

A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2 that can transform normal T-lymphocytes and can replicate in both T- and B-cell lines. The virus is related to but distinct from HTLV-1.


MC2 Receptor
Receptor, Melanocortin-2
Melanocortin-2 Receptor
Melanocortin Receptor 2
Receptor, Melanocortin, Type 2

A melanocortin receptor subtype found primarily in the ADRENAL CORTEX. It shows specificity for ADRENOCORTICOTROPIC HORMONE.


Simian T-lymphotropic virus 3
STLV-L
Simian T-lymphotropic virus-L
STLV-3

Strains of PRIMATE T-LYMPHOTROPIC VIRUS 3 isolated from diverse primate species.


An herbicide with strong irritant properties. Use of this compound on rice fields, orchards, sugarcane, rangeland, and other noncrop sites was terminated by the EPA in 1985. (From Merck Index, 11th ed)


A sulfanilamide that is used as an anti-infective agent.


Hemovigilance
Blood Safety
Blood Supply Safety

Activities involved in ensuring the safety of the blood for BLOOD TRANSFUSIONS including collecting information on BLOOD DONORS and recipients, collection, testing, and storage of the blood.


Synapses, Immunological
Immunological Synapses

The interfaces between T-CELLS and ANTIGEN-PRESENTING CELLS. Supramolecular organization of proteins takes place at these synapses involving various types of immune cells. Immunological synapses can have several functions including LYMPHOCYTE ACTIVATION; enhancing, balancing, or terminating signaling; or directing cytokine secretion.


Congo Virus Infection
Hemorrhagic Fever, Crimean
Infection, Congo Virus
Crimean-Congo Haemorrhagic Fever
Congo-Crimean Hemorrhagic Fever
Crimean-Congo Hemorrhagic Fever

A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).


Caprolactam
Hexahydro-2H-Azepin-2-One
Aminocaproic Lactam

Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.


Intracellular step that follows VIRUS INTERNALIZATION during which the viral nucleic acid and CAPSID are separated.


Anxiety disorder characterized by the persistent and irrational fear, anxiety, or avoidance of social or performance situations.


Caudal Nucleus, Trigeminal
Trigeminal Caudal Nucleus

The caudal portion of the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), a nucleus involved with pain and temperature sensation.


Interferon-Stimulated Gene Factor 3, gamma Subunit

An interferon regulatory factor that recruits STAT1 PROTEIN and STAT2 PROTEIN heterodimers to interferon-stimulated response elements and functions as an immediate-early protein.


Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.


An ancient Chinese system of postures, exercises, breathing techniques, and meditations designed to improve and enhance the body's QI.


Catheterization, Heart
Heart Catheterization
Catheterization, Cardiac
Cardiac Catheterization

Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.


Corticoids
Corticosteroids
Adrenal Cortex Hormones


Steroid 11 Hydroxylase
Steroid-11-Hydroxylase
CYP11B1
11 beta-Hydroxylase
CYP 11B1
Steroid 11-Hydroxylase
Steroid 11-beta-Hydroxylase
Cytochrome P-450(11 beta)
Cytochrome P450 11B1
Cytochrome P-450 CYP11B1
Steroid 11-beta-Monooxygenase

A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).


An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.


A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.


The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.


Amaranth Plant
Redroot Pigweed
Amaranthus

A plant genus, in the family AMARANTHACEAE, best known as a source of high-protein grain crops and of Red Dye No. 2 (AMARANTH DYE). Tumbleweed sometimes refers to Amaranthus but more often refers to SALSOLA.


Androgen-Binding Protein
Androgen Binding Protein

Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.


CDC28 Protein Kinase, S cerevisiae
p34cdc28 Kinase, S cerevisiae
CDC28 protein, S cerevisiae

A protein kinase encoded by the Saccharomyces cerevisiae CDC28 gene and required for progression from the G1 PHASE to the S PHASE in the CELL CYCLE.


A plant genus of the family LAMIACEAE that contains isoscutellarein-7-O-(allosyl(1-2)glucoside).


Non-Receptor Tyrosine-Protein Kinase TYK2

A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.


Chromosome 12
Chromosomes, Human, Pair 12

A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.


Estetrol
15 alpha-Hydroxyestriol
15-alpha-Hydroxy-Estriol

A metabolite of ESTRIOL with a 15-alpha-hydroxyl group. Estetrol can be converted from estriol sulfate or DEHYDROEPIANDROSTERONE SULFATE by the fetal-placental unit.


Rats, Inbred WF
Rats, Wistar Furth
Rats, WF
Rats, Inbred Wistar Furth

An inbred strain of rat that is used in BIOMEDICAL RESEARCH.


Desmoplastic Fibroblastoma
Collagenous Fibroma
Fibroma, Desmoplastic

An extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. It appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1441)


Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

Wilms Tumor-Aniridia-Genitourinary Anomalies-MR Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

A contiguous gene syndrome associated with hemizygous deletions of chromosome region 11p13. The condition is marked by the combination of WILMS TUMOR; ANIRIDIA; GENITOURINARY ABNORMALITIES; and INTELLECTUAL DISABILITY.


Calumny Defamation Slander Vilification Libel

Orally communicated statements intended to harm.


CYP21 Enzymes
CYP21 Family
Cytochrome P450 Family 21

A cytochrome P450 enzyme family that includes STEROID 21-HYDROXYLASE, which functions in the biosynthesis of STEROIDS.


Sailors
Air Force Personnel
Military Deployment
Armed Forces Personnel
Soldiers
Military
Army Personnel
Military Personnel
Marines
Coast Guard
Navy Personnel
Submariners

Persons including soldiers involved with the armed forces.


A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.


An organochlorine insecticide that is slightly irritating to the skin. (From Merck Index, 11th ed, p482)


Home Health Nursing
Home Health Care Nursing

A nursing specialty in which skilled nursing care is provided to patients in their homes by registered or licensed practical NURSES. Home health nursing differs from HOME NURSING in that home health nurses are licensed professionals, while home nursing involves non-professional caregivers.


Preferentially rated health-related activities or functions to be used in establishing health planning goals. This may refer specifically to PL93-641.


Hyalinosis Cutis et Mucosae
Urbach-Wiethe Disease
Lipoproteinosis
Urbach-Wiethe Lipoid Proteinosis
Urbach-Wiethe Syndrome
Lipoidproteinosis
Lipoid Proteinosis of Urbach and Wiethe

An autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of SKIN; MUCOSA; and certain VISCERA. This disorder is caused by mutation in the extracellular matrix protein 1 gene (ECM1). Clinical features include hoarseness and skin eruption due to widespread deposition of HYALIN.


Bony outgrowth usually found around joints and often seen in conditions such as ARTHRITIS.


Chromosome Fragility
Chromosomal Fragility

Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related aberrations.


A plant genus of the family Nyssaceae. Named for the water nymph from classical mythology, these species grow in moist habitats and are tolerant of flooding.


Plasminogen Activator, Urokinase Receptors

Plasminogen Activator Receptor, Urokinase Type

Receptor, Urokinase Plasminogen Activator

Urokinase Plasminogen Activator Receptors

Urokinase-Type Plasminogen Activator Receptors

Receptors, Urokinase Plasminogen Activator

An extracellular receptor specific for UROKINASE-TYPE PLASMINOGEN ACTIVATOR. It is attached to the cell membrane via a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and plays a role in the co-localization of urokinase-type plasminogen activator with PLASMINOGEN.


Hospital equipment and supplies, packaged for long-term storage, sufficient to set up a general hospital in an emergency situation. They are also called Packaged Disaster Hospitals and formerly Civil Defense Emergency Hospitals.


Adaptor Protein Complex 3
AP3 Adaptor Complex
Clathrin Assembly Protein Complex 3
Clathrin Adaptor Protein Complex 3
Adaptor-Related Protein Complex 3

An adaptor protein complex found primarily on perinuclear compartments.


Hypertonic Solution, Saline
Hypertonic Saline Solutions
Hypertonic Solutions, Saline
Saline Solutions, Hypertonic
Sodium Chloride Solution, Hypertonic
Sodium Chloride Solutions, Hypertonic
Saline Solution, Hypertonic
Hypertonic Saline Solution

Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).


A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)


Myristate
Myristic Acid
Tetradecanoic Acid

A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed)


Receptors, Neuropeptides
Neuropeptide Receptor
Neuropeptide Receptors
Receptors, Neuropeptide

Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behavior of cells. Many neuropeptides are also hormones outside of the nervous system.


Dihydralazine
Depressan
Dihydralazine Sulfate
Dihydrallazine
Dihydrazinophthalazin

1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)


Pneumomediastinum
Emphysema, Mediastinal
Mediastinal Emphysema

Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.


Myelin Protein Zero
Myelin P0 Protein
P0 Protein
Protein Zero, Peripheral Nerve Myelin
P0 Glycoprotein

A protein that accounts for more than half of the peripheral nervous system myelin protein. The extracellular domain of this protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. It can behave as a homophilic adhesion molecule through interactions with its extracellular domains. (From J Cell Biol 1994;126(4):1089-97)


Alkylmercurials
Alkylmercury Compounds
Alkyl Mercury Compounds

Organic mercury compounds in which the mercury is attached to an alkyl group.


Infections with bacteria of the family PISCIRICKETTSIACEAE, causing septicemic disease of salmonid fish (SALMONIDAE). Piscirickettsia-like bacteria are also associated with disease syndromes in non-salmonid fish.


Measurement of ocular tension (INTRAOCULAR PRESSURE) with a tonometer. (Cline, et al., Dictionary of Visual Science, 4th ed)


Medical Decision Making, Computer-Assisted

Use of an interactive computer system designed to assist the physician or other health professional in choosing between certain relationships or variables for the purpose of making a diagnostic or therapeutic decision.


Dissociative Anesthetics
Anesthetics, Dissociative

Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)


National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It supports research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress. It was established in 1986.


Deptomycin
LY-146032
Daptomycin
Cubicin
Daptomycin, 9-L beta-Aspartic Acid

A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.


Auditory Brainstem Implants
Brain Stem Implants, Auditory
Auditory Brain Stem Implants

Multi-channel hearing devices typically used for patients who have tumors on the COCHLEAR NERVE and are unable to benefit from COCHLEAR IMPLANTS after tumor surgery that severs the cochlear nerve. The device electrically stimulates the nerves of cochlea nucleus in the BRAIN STEM rather than the inner ear as in cochlear implants.


Baclofen Receptor
GABA-B Receptors
Baclofen Receptors
Receptors, Baclofen
GABA-B Receptor
Receptors, GABA-B

A subset of GABA RECEPTORS that signal through their interaction with HETEROTRIMERIC G-PROTEINS.


DNA sequences that form the coding region for the HIV-1 regulatory protein vpu (viral protein U) that greatly increases the export of virus particles from infected cells. The vpu genes are not present in HIV-2 or SIMIAN IMMUNODEFICIENCY VIRUS.


Agrimonia
Agrimonia eupatoria
Agrimony
Agrimonia pilosa

A plant genus of the family ROSACEAE that has been used in folk treatment of diabetes. Members contain agrimoniin (TANNINS).


General Practitioners
Physicians, General Practice

Physicians whose practice is not restricted to a specific field of MEDICINE.


T-Cell Receptor alpha Genes
Genes, T-Cell Receptor alpha
TcR alpha Genes
T-Cell Receptor alpha-Chain Genes

DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes.


Tolloid Metalloproteinase
Tolloid-Like Metalloproteinases
Tolloid Metalloproteases
Tolloid-Like Enzymes

A family of metalloproteases that are related to the DROSOPHILA protein tolloid, which is a gene product necessary for dorsal-ventral patterning in early Drosophila embryogenesis. Many members of the group may play a significant role in intercellular signaling.


Hypothalamic-Pituitary Unit
Hypothalamic Hypophyseal System
Hypothalamo-Hypophyseal System
Hypophyseal Portal System
Hypothalamo-Pituitary-Adrenal Axis

A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.


Influenza A Virus, H10N8 Subtype
H10N8 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins HEMAGGLUTININ 10 and NEURAMINIDASE 8. The H10N8 subtype usually infects domestic birds (POULTRY) but there have been some human infections reported.


Flaviviridae Infections
Infections, Flaviviridae

Infections with viruses of the family FLAVIVIRIDAE.


Facilities which administer the delivery of psychologic and psychiatric services to people living in a neighborhood or community.


Isobutyl-2-cyanoacrylate
Bucrilate
Bucrylate
Isobutyl alpha-Cyanoacrylate
Isobutylcyanoacrylate
Isobutyl Cyanoacrylate

Cyanoacrylate tissue adhesive also used to occlude blood vessels supplying neoplastic or other diseased tissue.


Propofol-Related Infusion Syndrome
Propofol Syndrome
Propofol Infusion Syndrome

Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE.


A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.


Pulmonary Valve Atresias
Atresia, Pulmonary
Pulmonary Atresia
Pulmonary Atresias
Atresia, Pulmonary Valve
Atresias, Pulmonary
Pulmonary Valve Atresia
Atresias, Pulmonary Valve

A congenital heart defect characterized by the narrowing or complete absence of the opening between the RIGHT VENTRICLE and the PULMONARY ARTERY. Lacking a normal PULMONARY VALVE, unoxygenated blood in the right ventricle can not be effectively pumped into the lung for oxygenation. Clinical features include rapid breathing, CYANOSIS, right ventricle atrophy, and abnormal heart sounds (HEART MURMURS).


Basic Amino Acids
Basic Amino Acid
Amino Acids, Basic

Amino acids with side chains that are positively charged at physiological pH.


A subfamily of Q-SNARE PROTEINS which occupy the same position in the SNARE complex as the N-terminal SNARE domain of SNAP-25 and which also are most similar to the N-terminal region of SNAP-25 in their AMINO ACID SEQUENCE.


Amnesia, Hysterical
Amnesia, Dissociative
Amnesia, Temporary
Amnesia, Global
Amnesia-Memory Loss
Amnesia, Tactile
Amnesia
Amnestic State

Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)


A plant genus of the family COMMELINACEAE of perennial herbs with blue flowers.


Coliphage P1
P1 Phage
Enterobacteria phage P1
Bacteriophage P1
Phage P1

A species of temperate bacteriophage in the genus P1-like viruses, family MYOVIRIDAE, which infects E. coli. It is the largest of the COLIPHAGES and consists of double-stranded DNA, terminally redundant, and circularly permuted.


A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)


Dopamine Receptors
Dopamine Receptor
Receptors, Dopamine

Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.


Kidney Tubules, Proximal
Proximal Renal Tubule
Proximal Kidney Tubule

The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.


Gm Allotypes
Immunoglobulin Gm Allotypes
Ig Gm Allotypes
Allotypes, Immunoglobulin Gm

Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.


A phosphodiesterase that specifically cleaves the 3'-phosphate linkage of 2',3'-cyclic nucleotides. It is found at high level in the cytoplasm of cells that form the MYELIN SHEATH.


Psychotherapy, Rational-Emotive
Psychotherapy, Rational
Rational Psychotherapy
Rational-Emotive Psychotherapy

The replacement of illogical and unrealistic ideas with more realistic and adaptive ones through direct intervention and confrontation by the therapist.


Muscular Atrophy, Postpoliomyelitis
Post-Polio Syndrome
Post-Poliomyelitis Muscular Atrophy
Postpoliomyelitis Syndrome
Post-Poliomyelitis Syndrome
Postpoliomyelitis Muscular Atrophy

A syndrome characterized by new neuromuscular symptoms that occur at least 15 years after clinical stability has been attained in patients with a prior history of symptomatic poliomyelitis. Clinical features include new muscular weakness and atrophy of the limbs, bulbar innervated musculature, and muscles of respiration, combined with excessive fatigue, joint pain, and reduced stamina. The process is marked by slow progression and periods of stabilization. (From Ann NY Acad Sci 1995 May 25;753:68-80)


Cell Line, Transformed
Transformed Cell Line

Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.


Macrophage, Pulmonary
Pulmonary Macrophages
Alveolar Macrophages
Macrophages, Alveolar
Macrophages, Pulmonary
Pulmonary Macrophage

Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.


Vancomycin Resistant Enterococci
Vancomycin-Resistant Enterococci

Strains of the genus Enterococcus that are resistant to the antibiotic VANCOMYCIN. The enterococci become resistant by acquiring plasmids carrying genes for VANCOMYCIN RESISTANCE.


Sodium Isethionate
Isethionic Acid
Isethionic Acid Monopotassium Salt
Isethionic Acid Monoammonium Salt
Hydroxyethylsulfonic Acid
Isethionic Acid Monosodium Salt

A colorless, syrupy, strongly acidic liquid that can form detergents with oleic acid.


Mycobacterium avium intracellulare Infection

A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.


Guinea Worm Infection
Dracunculosis
Dracunculiasis
Guinea Worm Disease

Infection with nematodes of the genus Dracunculus. One or more worms may be seen at a time, with the legs and feet being the most commonly infected areas. Symptoms include pruritus, nausea, vomiting, diarrhea, or asthmatic attacks.


Inhibitors of Poly(ADP-ribose) Polymerases

Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES.


Malformations Due to Abnormal Postmigrational Development

Malformations of Cortical Development, Group III

Malformations Secondary to Abnormal Postmigrational Development

Cortical malformations secondary to abnormal cortical maturation after CELL MIGRATION in NEUROGENESIS. This group includes injury to the cortex during later stages of cortical development such as POLYMICROGYRIA and focal cortical dysplasias.


Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.


Use for general articles concerning medical education.


Stem Cells, Embryonic
Embryonic Stem Cells

Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.


A monosynaptic reflex elicited by stimulating a nerve, particularly the tibial nerve, with an electric shock.


The parent cells that give rise to both cells of the MEGAKARYOCYTE and the ERYTHROCYTE lineages.


Carnitine-Acetyl-CoA-Transferase
Carnitine O-Acetyltransferase
Carnitine Acetyltransferase

An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1.7.


An enzyme that catalyzes the oxidation of L-2-aminoadipate 6-semialdehyde to L-2-aminoadipate (alpha-aminoadipic acid). It is involved in the biosynthetic pathway of LYSINE.


A highly vascular ovoid body of chemoreceptive tissue lying adjacent to the TYMPANIC CAVITY. It is derived from NEURAL CREST tissue and is considered part of the diffuse neuroendocrine system. It is the site of a rare neoplasm called a GLOMUS TYMPANICUM TUMOR.


A genus of strictly anaerobic, nonsporeforming gram-negative bacteria in the family Fusobacteriaceae. Species in this genus are popularly used in biochemical research.


A genus of gram-positive bacteria that forms a branched mycelium. It commonly occurs as a saprophytic form in soil and aquatic environments.


Periactin Viternum Antergan Dihexazin Cyproheptadine Peritol

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.


Conformational transitions of the shape of a protein to various unfolded states.


The production and release of substances such as NEUROTRANSMITTERS or HORMONES from nerve cells.


A species of the genus YERSINIA, isolated from both man and animal. It is a frequent cause of bacterial gastroenteritis in children.


A species of BORDETELLA that is parasitic and pathogenic. It is found in the respiratory tract of domestic and wild mammalian animals and can be transmitted from animals to man. It is a common cause of bronchopneumonia in lower animals.


Health insurance plans that are intended to be for profit.


Antigen detected when eosinophil granules are released.


An order of flowering plants also known as the buttercup family.


Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.


Cytochrome c-551 Peroxidase
Cytochrome Peroxidase
Cytochrome-c Peroxidase

A hemeprotein which catalyzes the oxidation of ferrocytochrome c to ferricytochrome c in the presence of hydrogen peroxide. EC 1.11.1.5.


The psychoanalytic concept that man instinctively seeks to avoid pain and discomfort and strives for gratification and pleasure.


A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.


Disturbances in the body's WATER-ELECTROLYTE BALANCE.


The signs of life that may be monitored or measured, namely pulse rate, respiratory rate, body temperature, and blood pressure.


Inorganic compounds that contain the OH- group.


The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.


A plant genus of the family Asparagaceae. Members contain steroidal saponins.


The fraudulent misrepresentation of the diagnosis and treatment of disease.


Technique Utilization
Procedures and Techniques Utilization
Procedure Utilization

Extent of use of procedures or techniques. It includes overuse and underuse.


The health and other ramifications of military and civilian exposure to WAR .


A group of compounds that are derivatives of the amino acid 2-amino-2-methylpropanoic acid.


A genus of straight, gram-negative bacterial rods which are facultatively anaerobic and motile by peritrichous flagella. This genus is found in human and animal feces, soil, water, and dairy products. It is an opportunistic pathogen in humans. (From Bergey's Manual of Determinative Bacteriology, 9th ed)


An infraorder of PRIMATES comprised of the families CERCOPITHECIDAE (old world monkeys); HYLOBATIDAE (siamangs and GIBBONS); and HOMINIDAE (great apes and HUMANS). With the exception of humans, they all live exclusively in Africa and Asia.


Derivatives of acrylic acid (the structural formula CH2=CHCO2H), including its salts and esters.


An enzyme that catalyzes the oxidation of cholesterol in the presence of molecular oxygen to 4-cholesten-3-one and hydrogen peroxide. The enzyme is not specific for cholesterol, but will also oxidize other 3-hydroxysteroids. EC 1.1.3.6.


Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.


Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.


A genus of gram-negative aerobic bacteria whose cells are minute coccobacilli. It consists of both parasitic and pathogenic species.


Bacteria that are capable of NITROGEN FIXATION.


Metallochrome indicator that changes color when complexed to the calcium ion under physiological conditions. It is used to measure local calcium ion concentrations in vivo.


A family of flattened, translucent flukes (TREMATODA) occurring in the gut, gallbladder, bile ducts, liver or pancreatic ducts of amphibians, reptiles, birds, and mammals. (Noble et al., Parasitology: the Biology of Animal Parasites, 6th ed, p188)


A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)


Electrophoresis applied to BLOOD PROTEINS.


The measurement of magnetic fields generated by electric currents from the heart. The measurement of these fields provides information which is complementary to that provided by ELECTROCARDIOGRAPHY.


Using coding methods, such as calculating the changes in a signal intensity, to minimize a series of images from DIAGNOSTIC IMAGING.


A gizzard-like structure of the crustacean digestive system.


Animal Remains
Body Remains
Human Remains
Skeletal Remains

The physical entity of a deceased human or animal.


Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.


A species of CORYNEBACTERIUM isolated from abscesses of warm-blooded animals.


The development and use of techniques and equipment to study or perform chemical reactions, with small quantities of materials, frequently less than a milligram or a milliliter.


A rapid-growing, nonphotochromogenic species of MYCOBACTERIUM originally isolated from human smegma and found also in soil and water. (From Dorland, 28th ed)


A yellow pigment that accumulates in the MACULA LUTEA. It is composed of LUTEIN, meso-zeaxanthin, and ZEAXANTHIN.


Enzymes that catalyze the transfer of aldehyde or ketone residues. EC 2.2.


The sixth planet in order from the sun. It is one of the five outer planets of the solar system. Its twelve natural satellites include Phoebe and Titan.


A genus of tick-borne protozoa parasitic in the lymphocytes, erythrocytes, and endothelial cells of mammals. Its organisms multiply asexually and then invade erythrocytes, where they undergo no further reproduction until ingested by a transmitting tick.


Persistent abnormal dilatation of the bronchi.


A plant genus of the family ULMACEAE. Members contain PHENANTHRENES and COUMARINS.


SUGARS containing an amino group. GLYCOSYLATION of other compounds with these amino sugars results in AMINOGLYCOSIDES.


Adenoma, Papillary
Adenoma, Follicular
Adenoma, Basal Cell
Adenoma, Trabecular
Adenoma, Monomorphic
Adenoma, Microcystic
Adenoma

A benign epithelial tumor with a glandular organization.


Wearable sound-amplifying devices that are intended to compensate for impaired hearing. These generic devices include air-conduction hearing aids and bone-conduction hearing aids. (UMDNS, 1999)


An order of bacteria within the class DELTAPROTEOBACTERIA, of the phylum PROTEOBACTERIA, which comprises four families.


Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.


The book composed of writings generally accepted by Christians as inspired by God and of divine authority. (Webster, 3d ed)


Nairobi sheep disease virus
Dugbe virus
Ganjam virus

A species of NAIROVIRUS, transmitted by the ixodid ticks and producing a lethal gastroenteritis in sheep and goats. Though a major veterinary pathogen, its effect on humans has not been firmly established.


Individuals connecting by family, work or other interests. It also includes connectivity facilitated by computer-based communications.


Bacillus thuringiensis
Thuricide
Dipel
Bacilan

A species of gram-positive bacteria which may be pathogenic for certain insects. It is used for the biological control of the Gypsy moth.


Voluntary agencies concerned with prevention and treatment of tuberculosis.


Pollutants, present in soil, which exhibit radioactivity.


A genus of microaerophilic, gram-negative bacteria that forms crystals of the mineral magnetite in special organelles called MAGNETOSOMES.


Genus of flowering herbaceous perennial plants and vines in the family Polygonaceae.


Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.


Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane.


Termination Release Factor
Peptide Termination Factors

Proteins that are involved in the peptide chain termination reaction (PEPTIDE CHAIN TERMINATION, TRANSLATIONAL) on RIBOSOMES. They include codon-specific class-I release factors, which recognize stop signals (TERMINATOR CODON) in the MESSENGER RNA; and codon-nonspecific class-II release factors.


A genus of the family CORONAVIRIDAE that causes respiratory or gastrointestinal disease in avian species (or birds). The type species, AVIAN CORONAVIRUS, includes the previously separate species TURKEY CORONAVIRUS; and INFECTIOUS BRONCHITIS VIRUS.


Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.


A genus of GRAM-POSITIVE ENDOSPORE-FORMING RODS in the family Paenibacillaceae.


Klebsiella pneumoniae
Klebsiella rhinoscleromatis

A gram-negative, facultatively anaerobic, rod-shaped bacterium found consistently and exclusively in patients with RHINOSCLEROMA and their contacts. Formerly an individual species, it is now considered a subspecies of K. pneumoniae.


Works about sources listing chemicals and their characteristics.


The property of dentin that permits passage of light, heat, cold, and chemical substances. It does not include penetration by microorganisms.


Perfusion Scintigraphy
Perfusion Imaging

Imaging blood flow to specific organs or areas of the body by following the distribution of radioactively labeled tracers injected in to the blood stream.


An order of photosynthetic bacteria representing a physiological community of predominantly aquatic bacteria.


Proline-Rich Peptide Domains
Proline-Rich Protein Domains

Protein domains that are enriched in PROLINE. The cyclical nature of proline causes the peptide bonds it forms to have a limited degree of conformational mobility. Therefore the presence of multiple prolines in close proximity to each other can convey a distinct conformational arrangement to a peptide chain.


Tomato spotted wilt virus
Tospovirus
Impatiens necrotic spot virus

A genus of plant viruses in the family BUNYAVIRIDAE. Tomato spotted wilt virus is the type species. Transmission occurs by at least nine species of thrips.


Health care services related to human REPRODUCTION and diseases of the REPRODUCTIVE SYSTEM. Services are provided to both sexes and usually by physicians in the medical or the surgical specialties such as REPRODUCTIVE MEDICINE; ANDROLOGY; GYNECOLOGY; OBSTETRICS; and PERINATOLOGY.


Locomotor behavior not involving a steering reaction, but in which there may be a turning random in direction. It includes orthokinesis, the rate of movement and klinokinesis, the amount of turning, which are related to the intensity of stimulation.


Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).


Unstable isotopes of potassium that decay or disintegrate emitting radiation. K atoms with atomic weights 37, 38, 40, and 42-45 are radioactive potassium isotopes.


A species of rod-shaped bacteria that is a common soil saprophyte. Its spores are widespread and multiplication has been observed chiefly in foods. Contamination may lead to food poisoning.


Chlorzoxazone
Parafon Forte DSC
Parafon
Paraflex

A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)


A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.


Interdisciplinary programs of academic study that de-stigmatize disease, illness, and impairment.


A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis.


Removal of an autonomic or sensory ganglion by any means.


Most common follicular odontogenic cyst. Occurs in relation to a partially erupted or unerupted tooth with at least the crown of the tooth to which the cyst is attached protruding into the cystic cavity. May give rise to an ameloblastoma and, in rare instances, undergo malignant transformation.


A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.


Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.


A plant genus of the family LAMIACEAE that contains phlorigidosides, iridoid glucosides and megastigmane glycosides.


The sole species of COCCIDIOIDES. It can cause an acute, benign respiratory infection as well as a fatal, chronic systemic disease.


The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.


A plant genus of the family Apocynaceae. Species of this genus contain 9-methoxyellipticine (ELLIPTICINES) which is the basis of one of the classes of ANTINEOPLASTIC AGENTS.


A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.


A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that are common in the marine environment and on the surfaces and in the intestinal contents of marine animals. Some species are bioluminescent and are found as symbionts in specialized luminous organs of fish.


Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)


Insufflation Anesthesia
Anesthesia, Inhalation

Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.


A culture-specific acute delusional syndrome occurring mostly in the Malay people and Southern Chinese. The syndrome is characterized by the individual's sudden experience of depersonalization depicted by the belief that his penis is shrinking into his abdomen and that he will die when this occurs. Although generally classified as a culture-specific syndrome, koro may be no more than a variant of castration anxiety (ANXIETY, CASTRATION) as it has been described in non-Asian patients.


Preventive dental services provided for students in primary and secondary schools.


A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.


An order of highly pleomorphic, gram-negative bacteria including both pathogenic and saprophytic species.


Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.


A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC TRANSCRIPTION by opening and remodeling CHROMATIN structure. It may also have enhancer activity.


A moderate-growing, photochromogenic species found in aquariums, diseased fish, and swimming pools. It is the cause of cutaneous lesions and granulomas (swimming pool granuloma) in humans. (Dorland, 28th ed)


Salivary Peptides
Salivary Proteins and Peptides
Salivary Gland Proteins
Salivary Proteins

Proteins and peptides found in SALIVA and the SALIVARY GLANDS. Some salivary proteins such as ALPHA-AMYLASES are enzymes, but their composition varies in different individuals.


Any of numerous winged hymenopterous insects of social as well as solitary habits and having formidable stings.


A short thick vein formed by union of the superior mesenteric vein and the splenic vein.


A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)


A general term for a malignant neoplasm derived from muscular tissue. (Stedman, 25th ed)


A bony proliferation and articular degeneration of the first METATARSOPHALANGEAL JOINT that is characterized by pain and a progressive decrease in the dorsiflexion range of motion.


Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.


Members of the class Arachnida, especially SPIDERS; SCORPIONS; MITES; and TICKS; which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.


A plant genus of the family ZYGOPHYLLACEAE. GUAIAC is obtained from G. officinale or G. sanctum. Some species in this genus are called lignum vitae which is also a common name for other trees.


Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.


A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is extremely pathogenic and causes severe dysentery. Infection with this organism often leads to ulceration of the intestinal epithelium.


An infraorder of snakes in the order Serpentes that includes all snakes except blind snakes and thread snakes.


Process of teaching a person to interact and communicate with a computer.


Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.


An evergreen tree commonly known as the monkey-puzzle tree. It grows to 1-1.5 m in diameter and 30-40 m in height, and is native to central and southern Chile, and western Argentina. Araucaria araucana is the hardiest among the conifers, and due to its longevity, is often described as a living fossil.


Negative Eugenics
Positive Eugenics
Eugenics

The attempt to improve the PHENOTYPES of future generations of the human population by fostering the reproduction of those with favorable phenotypes and GENOTYPES and hampering or preventing BREEDING by those with "undesirable" phenotypes and genotypes. The concept is largely discredited. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


A basement membrane in the cochlea that supports the hair cells of the ORGAN OF CORTI, consisting keratin-like fibrils. It stretches from the SPIRAL LAMINA to the basilar crest. The movement of fluid in the cochlea, induced by sound, causes displacement of the basilar membrane and subsequent stimulation of the attached hair cells which transform the mechanical signal into neural activity.


A family of gram-positive bacteria found regularly in the mouth and intestinal tract of man and other animals, in food and dairy products, and in fermenting vegetable juices. A few species are highly pathogenic.


Organic and inorganic compounds that contain iron as an integral part of the molecule.


Inorganic compounds that contain nitrogen as an integral part of the molecule.


Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.


A genus of gram-negative, facultatively anaerobic, straight rods which are motile by peritrichous flagella. Most strains produce a yellow pigment. This organism is isolated from plant surfaces, seeds, soil, and water, as well as from animals and human wounds, blood, and urine. (From Bergey's Manual of Determinative Bacteriology, 9th ed)


The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.


A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.


Persons with an incurable or irreversible illness at the end stage that will result in death within a short time. (From O'Leary et al., Lexikon: Dictionary of Health Care Terms, Organizations, and Acronyms for the Era of Reform, 1994, p780)


Analytical technique for studying substances present at enzyme concentrations in single cells, in situ, by measuring light absorption. Light from a tungsten strip lamp or xenon arc dispersed by a grating monochromator illuminates the optical system of a microscope. The absorbance of light is measured (in nanometers) by comparing the difference between the image of the sample and a reference image.


A FLUORESCENCE technique used in DENTISTRY for the analysis of mineral changes in DENTAL ENAMEL to detect early DENTAL CARIES, or for the evaluation other normal or pathological processes or lesions of the dental enamel.


Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).


Devices which provide an artificial temporary wall, or matrix, used in filling a prepared cavity.


A plant genus of the family LAMIACEAE that is a source of perilla alcohol and the oil is rich in alpha-linolenic acid (alpha-18:3).


Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor

Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. The linkage is in the form of a carbon-nitrogen bond. EC 6.3.5.


A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.


A plant genus of the family RUBIACEAE that has a name very similar to another plant genus, HAMAMELIS.


A group of compounds that contain the general formula R-OCH3.


Rough, noisy breathing during sleep, due to vibration of the uvula and soft palate.


The attitude or intellectual orientation that characterized many works of literature, painting, music, architecture, criticism, and historiography in Western civilization over a period from the late 18th to the mid-19th century.


Marriage Postponement
Dowry
Multiple Marriages
Mate Selection
Same-Sex Marriage
Marital Relationship
Marriage
Arranged Marriage
Consummation of Marriage
Consensual Union
Commonlaw Marriage
Polygamy
Marriage Duration
Polygyny
Remarriage
Nuptiality
Intermarriage
Husband-Wife Comparisons
Marriage Patterns
Marriage Age

The social institution involving legal and/or religious sanction whereby individuals of the same gender are joined together.


Agents that inhibit PHOSPHOINOSITIDE-3 KINASE activity.


A genus of aerobic, helical spirochetes, some species of which are pathogenic, others free-living or saprophytic.


The presence of albumin in the urine, an indicator of KIDNEY DISEASES.


A genus of obligately aerobic, thermophilic, gram-negative bacteria in the family Crenotrichaceae. They were isolated from submarine alkaline HOT SPRINGS in Iceland.


A disorder of the buccal mucosa resembling early leukoplakia, characterized by the presence of filmy opalescence of the mucosa in the early stages to a whitish gray cast with a coarsely wrinkled surface in the later stages, associated with intracellular edema of the spinous or malpighian layer. (Dorland, 27th ed)


A genus of gram-negative, chemoorganotrophic bacteria in the family CYTOPHAGACEAE. In some species there is a cyclic change in cell morphology.


Derivatives of malonic acid (the structural formula CH2(COOH)2), including its salts and esters.


A species of HANTAVIRUS causing nephropathia epidemica, a mild form of HEMORRHAGIC FEVER WITH RENAL SYNDROME. It is found in most of Europe and especially in Finland, along with its carrier rodent, the bank vole (Clethrionomys glareolus).


An eating disorder that is characterized by a cycle of binge eating (BULIMIA or bingeing) followed by inappropriate acts (purging) to avert weight gain. Purging methods often include self-induced VOMITING, use of LAXATIVES or DIURETICS, excessive exercise, and FASTING.


The point or frequency at which all flicker of an intermittent light stimulus disappears.


A plant genus of the family NYCTAGINACEAE. Members contain Mirabilis antiviral protein (a ribosome-inactivating protein).


A plant family of the order Nymphaeales, subclass Magnoliidae, class Magnoliopsida. They are aquatic plants.


Nutritional supplements combining PROBIOTICS (bacteria) and PREBIOTICS (sugars).


Proteins involved in the process of transporting molecules in and out the cell nucleus. Included here are: NUCLEOPORINS, which are membrane proteins that form the NUCLEAR PORE COMPLEX; KARYOPHERINS, which carry molecules through the nuclear pore complex; and proteins that play a direct role in the transport of karyopherin complexes through the nuclear pore complex.


Involuntary Treatment
Involuntary Hospitalization

Admission and confinement to a HOSPITAL without consent of person or persons confined.


Disorders of the mediastinum, general or unspecified.


A genus of fungi in the family Ophiostomataceae, order OPHIOSTOMATALES. Several species are the source of Dutch elm disease, which is spread by the elm bark beetle.


A plant species of the genus STEPHANIA, family MENISPERMACEAE, that contains tetrandrine and bisbenzylisoquinoline alkaloids.


A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.


The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.


A genus in the Family Anguillidae, Order Anguilliformes, that includes fresh water eels.


Temporal Lobectomy Behavior Syndrome
Kluver-Bucy Syndrome

A neurobehavioral syndrome associated with bilateral medial temporal lobe dysfunction. Clinical manifestations include oral exploratory behavior; tactile exploratory behavior; hypersexuality; BULIMIA; MEMORY DISORDERS; placidity; and an inability to recognize objects or faces. This disorder may result from a variety of conditions, including CRANIOCEREBRAL TRAUMA; infections; ALZHEIMER DISEASE; PICK DISEASE OF THE BRAIN; and CEREBROVASCULAR DISORDERS.


A species of migratory Old World locusts, in the family ACRIDIDAE, that are important pests in Africa and Asia.


Maprounea Excoecaria Sebastiania Macaranga Euphorbiaceae Alchornea Spondianthus


A genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods or coccobacilli. Organisms in this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Bacteroides species, and hence, this new genus was created.


Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.)


The use of mind to cure disease, particularly physical illness.


A species of CORONAVIRUS causing acute enteritis in swine. Infections have been seen mostly in Europe, where it is endemic, and in China.


The material that descends to the earth or water well beyond the site of a surface or subsurface nuclear explosion. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)


Used as a dental cement this is mainly zinc oxide (with strengtheners and accelerators) and eugenol. (Boucher's Clinical Dental Terminology, 4th ed, p50)


A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.


Deformities acquired after birth as the result of injury or disease. The joint deformity is often associated with rheumatoid arthritis and leprosy.


The dissociation of molecules in the air into positive and negative ions under the influence of an electric field.


A plant genus of the family CYPERACEAE. The seed contains oligostilbenes (STILBENES).


Inorganic compounds that contain selenium as an integral part of the molecule.


Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).


Drinking Water
Bottled Water
Potable Water


Hospitals engaged in educational and research programs, as well as providing medical care to the patients.


Transfer Factor
Dialyzable Leukocyte Extract

Factor derived from leukocyte lysates of immune donors which can transfer both local and systemic cellular immunity to nonimmune recipients.


An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.


Sexual intercourse between persons so closely related that they are forbidden by law to marry.


Yeast-like ascomycetous fungi of the family Saccharomycopsidaceae, order SACCHAROMYCETALES, isolated from the stomach of rabbits and some other animals.