Isophane Insulin, Human
Protophane
Protophan
NPH Insulin, Human
Insulatard
Novolin N
Humulin N
Insulin, NPH, Human

Human isophane insulin that is used to manage BLOOD GLUCOSE levels in patients with DIABETES.


An alkyl polyglycol ether of LAURYL ALCOHOL, chemically defined as an alcohol ethoxylate having an average alkyl chain of 12–14 carbon atoms, and an ethylene oxide chain of 9 ethylene oxide units. It is used as a detergent, and medically as a local anesthetic, and as a sclerosing agent for the treatment of ESOPHAGEAL AND GASTRIC VARICES and VARICOSE VEINS.


An acetanilide and piperazine derivative that functions as a SODIUM CHANNEL BLOCKER and prevents the release of enzymes during MYOCARDIAL ISCHEMIA. It is used in the treatment of ANGINA PECTORIS.


Peritoneum, Parietal
Visceral Peritoneum
Parietal Peritoneum
Parametrium
Peritoneum, Visceral
Peritoneum

A membrane of squamous EPITHELIAL CELLS, the mesothelial cells, covered by apical MICROVILLI that allow rapid absorption of fluid and particles in the PERITONEAL CAVITY. The peritoneum is divided into parietal and visceral components. The parietal peritoneum covers the inside of the ABDOMINAL WALL. The visceral peritoneum covers the intraperitoneal organs. The double-layered peritoneum forms the MESENTERY that suspends these organs from the abdominal wall.


Physician's Practice Patterns
Patterns, Clinical Practice
Prescribing Patterns, Physician
Practice Patterns, Clinical
Practice Patterns, Physician's
Practice Patterns, Physicians'
Clinical Practice Patterns
Pattern, Clinical Practice
Clinical Practice Pattern
Practice Pattern, Clinical

Patterns of practice related to diagnosis and treatment as especially influenced by cost of the service requested and provided.


Pars Reticularis
Substantia Nigra Pars Reticulata
Substantia Nigra Reticulata
Substantia Nigra, Pars Reticulata
Pars Reticulata
Substantia Nigra Pars Lateralis
Pars Lateralis

A region in the substantia nigra located ventral and lateral to the PARS COMPACTA.


Adult-Onset Idiopathic Torsion Dystonias

Acquired and inherited conditions that feature DYSTONIA as a primary manifestation of disease. These disorders are generally divided into generalized dystonias (e.g., dystonia musculorum deformans) and focal dystonias (e.g., writer's cramp). They are also classified by patterns of inheritance and by age of onset.


Loperamide Hydrochloride
Loperamide Monohydrochloride
Imodium
Loperamide
R-18553

One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.


A suborder of chewing lice, in the order PHTHIRAPTERA, that are parasites of birds and mammals.


Kung Fu
Gongfu
Judo
Aikido
Gong Fu
Karate
Martial Arts
Wushu
Tae Kwon Do
Jujitsu
Hap Ki Do

Activities in which participants learn self-defense mainly through the use of hand-to-hand combat. Judo involves throwing an opponent to the ground while karate (which includes kung fu and tae kwon do) involves kicking and punching an opponent.


Cyanamide, Calcium (2:1) Salt
Temposil
Abstem
Cyanamide
Calcium Carbimide
Cyanamide, Calcium Salt
Citrated Calcium Cyanamide
Cyanamide, Calcium (1:1) Salt
Calcium Cyanamide
Carbimide
Colme

A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.


Care, Preoperative
Procedures, Preoperative
Preoperative Procedure
Preoperative Procedures
Procedure, Preoperative
Preoperative Care

Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)


Heterozygote
Carriers, Genetic
Genetic Carriers

An individual having different alleles at one or more loci regarding a specific character.


Cabbage, Skunk
Araceae
Pistia stratiotes
Monstera
Lettuce, Water
Pistia
Aroideae
Aroids
Lysichiton
Rhaphidophora
Dracunculus Plant
Orontium
Skunk Cabbage
Symplocarpus


Rho(D) Immune Globulin Intravenous (Human)

Immunizing agent containing IMMUNOGLOBULIN G anti-Rho(D) used for preventing Rh immunization in Rh-negative individuals exposed to Rh-positive red blood cells.


Receptor, Ephrin B
EphB Receptors
EphA Receptors
Ephrin B Receptor
Ephrin B Receptors
Ephrin Receptors
Ephrin A Receptors
Receptors, Eph Family
Eph Receptors
Eph Family Receptors
Eph Receptor Tyrosine Kinase
EphB Receptor

A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.


Medieval History (Medicine)
Medieval History
History, Medieval
History of Medicine, Renaissance
Medicine, Medieval History
Medicine, Renaissance
History of Medicine, Medieval
Renaissance Medicine

The period of the history of medicine from 500 through 1450 A.D.


CELO Virus
Fowl adenovirus A
Fowl Adenovirus 1

A serotype of the species Fowl adenovirus A.


Xylazine
Xylazine Monohydrochloride
Xylaxine
Rompun
Xylazine Phosphate (1:1)
Xylazin
Xylazine Hydrochloride
BAY-Va 1470

An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.


Cress, Mouse-ear
A. thaliana
Arabidopsis thaliana
Arabidopsis

A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.


Albright Hereditary Osteodystrophy with Multiple Hormone Resistance

A hereditary syndrome clinically similar to HYPOPARATHYROIDISM. It is characterized by HYPOCALCEMIA; HYPERPHOSPHATEMIA; and associated skeletal development impairment and caused by failure of response to PARATHYROID HORMONE rather than deficiencies. A severe form with resistance to multiple hormones is referred to as Type 1a and is associated with maternal mutant allele of the ALPHA CHAIN OF STIMULATORY G PROTEIN.


Honeybee Mite
Varroa destructor
Varroa
Varroidae

A species of mite that is a parasite of honeybees.


Nits
Head Louse
Head Lice
Body Lice
Pediculi
Body Louse
Pediculus

Lice of the genus Pediculus, family Pediculidae. Pediculus humanus corporus is the human body louse and Pediculus humanus capitis is the human head louse.


alpha 2-Acute Phase Globulin
alpha 1-Acute Phase Globulin
alpha 1-Macroglobulin
alpha-Macroglobulins
Slow alpha 2-Macroglobulins
alpha-Macrofetoproteins
alpha 2-Acute Phase Globulins
alpha 1-Acute Phase Protein
45S RNP
alpha-Macrofetoprotein
Acute-Phase alpha 1-Protein
Slow alpha 2-Globulin

Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.


Hidradenoma Papilliferum
Anogenital Papillary Hidradenoma
Papillary Syringocystadenoma
Papillary Hidradenoma
Tubular Sweat Gland Adenomas
Syringocystadenoma Papilliferum

Various tubular forms of benign tumors of the SWEAT GLAND with glandular differentiation. Common types include syringocystadenoma papilliferum of the head and neck, and hidradenoma papilliferum of the vulva area. Hidradenoma papilliferum may be derived from mammary-like glands of the vulva.


Chaperonin Complexes
Chaperonin Protein Complex
Chaperonin Family
Chaperonins

A family of multisubunit protein complexes that form into large cylindrical structures which bind to and encapsulate non-native proteins. Chaperonins utilize the energy of ATP hydrolysis to enhance the efficiency of PROTEIN FOLDING reactions and thereby help proteins reach their functional conformation. The family of chaperonins is split into GROUP I CHAPERONINS, and GROUP II CHAPERONINS, with each group having its own repertoire of protein subunits and subcellular preferences.


Pavor Nocturnus, Childhood
Sleep Terrors
Night Terrors, Secondary
Sleep Terror Disorder
Pavor Nocturnus
Night Terrors, Childhood
Pavor Nocturnus, Adult
Night Terrors, Adult
Night Terrors, Primary
Night Terrors

A disorder characterized by incomplete arousals from sleep associated with behavior suggesting extreme fright. This condition primarily affects children and young adults and the individual generally has no recall of the event. Episodes tend to occur during stage III or IV. SOMNAMBULISM is frequently associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p391)


Melaleuca
Melaleuca vindifolia
Cajuput
Melaleuca leucadendra
Niaouli
Melaleuca cajuputi
Melaleuca alternifolia

A plant genus of the family MYRTACEAE. M. alternifolia foliage is a source of TEA TREE OIL. The common name of tea tree also refers to LEPTOSPERMUM or KUNZEA. M. vindifolia is a source of niaouli oil. M. cajuputi and M. leucadendra are sources of cajuput oil.


Cancer of the Gallbladder
Neoplasms, Gallbladder
Cancer of Gallbladder
Gall Bladder Cancer
Gallbladder Neoplasms
Gallbladder Cancer


Fractional Dose Drug Use
Off-Label Prescribing
Off-Label Use
Reduced-Dose Drug Use
Dose-Sparing Drug Use
Unlabeled Indication

The practice of prescribing or using a drug or a vaccine outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.


Kv1.2' Channel
Kv1.2 Potassium Channel, Beta Subunit
Kv1.2 Potassium Channel, Alpha Subunit
Kv1.2alpha
Kv1.2 Potassium Channel
Kvbeta1.2
KCNA2 Potassium Channel

A delayed rectifier subtype of shaker potassium channels that is selectively inhibited by a variety of SCORPION VENOMS.


Psoroptes
Psoroptes ovis
Psoroptidae
Chorioptes
Mites, Sheep Scab

Species in the genus PSOROPTIDAE, causing scabs in SHEEP.


Hereditary Motor And Sensory Neuropathy IV

Neuropathy, Hereditary Motor and Sensory, Type IV

Refsum Disease, Phytanic Acid Oxidase Deficiency

Hereditary Motor and Sensory Neuropathy Type IV

Refsum Disease, Phytanoyl-CoA Hydroxylase Deficiency

Hereditary Motor and Sensory Neuropathy, Type IV

Hereditary Type IV Motor and Sensory Neuropathy

An autosomal recessive familial disorder that usually presents in childhood with POLYNEUROPATHY; SENSORINEURAL HEARING LOSS; ICHTHYOSIS; ATAXIA; RETINITIS PIGMENTOSA; and CARDIOMYOPATHIES. (From Joynt, Clinical Neurology, 1991, Ch37, p58-9; Rev Med Interne 1996;17(5):391-8) This condition can be caused by mutation in the genes encoding peroxisomal phytanoyl-CoA hydroxylase or proteins associated peroxisomal membrane, leading to impaired catabolism of PHYTANIC ACID in PEROXISOMES.


Mercaptobutanedioic Acid Monogold(1+) Sodium Salt

A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.


Multimodal Imaging
Imaging, Hybrid
Imaging, Multimodal
Hybrid Imaging

The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.


MADS Domain Proteins
Agamous-Like Proteins
Agamous-Related Proteins
Deficiens-Agamous-Like Proteins
Deficiens-Agamous-Related Proteins

A superfamily of proteins that share a highly conserved MADS domain sequence motif. The term MADS refers to the first four members which were MCM1 PROTEIN; AGAMOUS 1 PROTEIN; DEFICIENS PROTEIN; and SERUM RESPONSE FACTOR. Many MADS domain proteins have been found in species from all eukaryotic kingdoms. They play an important role in development, especially in plants where they have an important role in flower development.


Photography, Intraoral
Intraoral Photography
Photography, Orthodontic
Photography, Dental

Photographic techniques used in ORTHODONTICS; DENTAL ESTHETICS; and patient education.


A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.


Progressive Relapsing Multiple Sclerosis

Multiple Sclerosis, Progressive Relapsing

Multiple Sclerosis, Remittent Progressive

Secondary Progressive Multiple Sclerosis

Remittent Progressive Multiple Sclerosis

Multiple Sclerosis, Secondary Progressive

A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)


Bursitis
Shoulder Adhesive Capsulitis
Capsulitis, Adhesive
Adhesive Capsulitis of the Shoulder
Adhesive Capsulitis
Frozen Shoulder
Pes Anserine Bursitis
Capsulitis

Inflammation or irritation of a JOINT CAPSULE.


Caspase Inhibitors
Capase Activation Inhibitors
Caspase Blockers
Caspase Activation Blockers
Caspase Activation Inhibitors

Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.


Nidation, Delayed
Embryo Implantation, Delayed
Embryo Implantation Inhibition
Implantation, Ovum, Delayed
Blastocyst Implantation Inhibition
Blastocyst Implantation Suppression
Embryo Implantation Suppression
Delayed Embryo Implantation
Blastocyst Implantation, Delayed
Ovum Implantation, Delayed

Delay in the attachment and implantation of BLASTOCYST to the uterine ENDOMETRIUM. The blastocyst remains unattached beyond the normal duration thus delaying embryonic development.


Zebra Mussels
Dreissena polymorpha
Mussels, Zebra
Dreissena

A species of freshwater MUSSELS in the genus DREISSENA. Their ability to attach to and colonize other mussels (UNIONIDAE) makes them ecologically destructive. Unlike most mussels, they do not possess a larval stage.


Depostat
Gestronol
Gestonorone Caproate
Gestronol Hexanoate
Primostat

A long-acting potent progestogen structurally related to PROGESTERONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1185)


Tumor, Optic Nerve, Malignant
Neoplasm, Benign, Optic Nerve
Malignant Optic Nerve Sheath Neoplasms
Optic Nerve Tumor, Malignant
Tumor, Benign, Optic Nerve
Benign Optic Nerve Sheath Neoplasms
Benign Optic Nerve Tumor
Neoplasms, Optic Nerve
Tumor, Malignant, Optic Nerve
Malignant Optic Nerve Tumor
Optic Nerve Neoplasms
Optic Nerve Neoplasm, Benign
Optic Nerve Sheath Neoplasm
Malignant Optic Nerve Neoplasm
Benign Optic Nerve Sheath Tumors
Optic Nerve Sheath Tumors, Malignant
Benign Optic Nerve Neoplasm
Optic Nerve Sheath Tumors
Tumor, Optic Nerve, Benign
Neoplasm, Optic Nerve, Benign
Optic Nerve Sheath Neoplasms, Malignant
Malignant Optic Nerve Sheath Tumors
Optic Nerve Sheath Tumors, Benign

Benign and malignant neoplasms that arise from the optic nerve or its sheath. OPTIC NERVE GLIOMA is the most common histologic type. Optic nerve neoplasms tend to cause unilateral visual loss and an afferent pupillary defect and may spread via neural pathways to the brain.


A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.


3-Methyl-1-phenyl-2-pyrazolin-5-one
MCI 186
Radicava
MCI-186
Norantipyrine
Norphenazone
Edarabone
1-Phenyl-3-methyl-5-pyrazolone
Phenylmethylpyrazolone
Edaravone

An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE.


Organic Arsenic Poisoning, Nervous System

Nervous System, Organic Arsenic Poisoning

Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)


Deficiency Disease, Lysine Alpha-Ketoglutarate Reductase

Lysine Alpha-Ketoglutarate Reductase Deficiency Disease

Saccharopine Dehydrogenase Deficiency Disease

Deficiency Disease, Saccharopine Dehydrogenase

Deficiency Disease, Alpha-Aminoadipic Semialdehyde

Alpha-Aminoadipic Semialdehyde Deficiency Disease

A group of inherited metabolic disorders which have in common elevations of serum LYSINE levels. Enzyme deficiencies of alpha-aminoadipic semialdehyde dehydrogenase and the SACCHAROPINE DEHYDROGENASES have been associated with hyperlysinemia. Clinical manifestations include mental retardation, recurrent emesis, hypotonia, lethargy, diarrhea, and developmental delay. (From Menkes, Textbook of Child Neurology, 5th ed, p56)


Billroth I Operation
Billroth I
Billroth II
Billroth II Procedure
Gastroenterostomy
Billroth II Operation
Billroth I Procedure

Gastrojejunostomy or anastomosis done between the stomach and the jejunum.


Myocardial Tumors (Rhabdomyomas and Fibromas)

Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.


Celosia cristata
Cockscomb, Common
Celosia

A plant genus of the family AMARANTHACEAE. Young leaves are used as vegetables in Asia. Members contain betacyanins, celogentins, betaxanthin, and celosian.


Long-term depression resulting from repeated low-frequency stimulation in only the pathway receiving the induction protocol. It follows induction of LONG-TERM POTENTIATION and reverses it.


Florisan N
Rytmil
Ulcolax
Bekunis Bisacodyl
Dulcolax
Bisacodyl Uniserts
Dulco-Lax
Fleet Bisacodyl
Bisalax
Laxanin
Bisco-Lax
Bisacodyl Tannex
Laxans-ratiopharm
Lünolax
Bisco-Zitron
Dulco-lax perles
Laxbene
ratio-Bisacodyl
Bicol
Bisac-Evac
Bisacodyl
Laxysat Bürger
Agaroletten
Laxagetten
Durolax
Apo-Bisacodyl

A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)


Cell Cycle-Transition Points
Cell Cycle Arrest
Cell Cycle Transition Points
Cell Cycle Control
Cell Cycle Checkpoints

The halting of progression of a cell through the CELL CYCLE when events in the CELL DIVISION process are not completed accurately or damage to cell components in the process are detected.


Brain Neoplasms
Primary Malignant Brain Tumors
Neoplasms, Intracranial
Malignant Primary Brain Neoplasms
Benign Neoplasms, Brain
Brain Cancer
Brain Neoplasm, Primary
Brain Neoplasms, Malignant, Primary
Brain Tumor, Recurrent
Neoplasms, Brain, Primary
Brain Neoplasms, Malignant
Cancer of Brain
Brain Neoplasms, Benign
Brain Tumor, Primary
Neoplasms, Brain, Benign
Primary Brain Neoplasms
Malignant Neoplasms, Brain
Brain Neoplasms, Primary Malignant
Malignant Primary Brain Tumors
Cancer of the Brain
Neoplasms, Brain, Malignant
Neoplasms, Brain
Primary Malignant Brain Neoplasms
Brain Tumors
Intracranial Neoplasms

Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.


Neomycin
Fradiomycin Sulfate
Neomycin Palmitate
Neomycin Sulfate

Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis.


Cajanus cajan
Pigeonpea Plant
Pea Plant, Pigeon
Cajanus

A plant genus of the family FABACEAE that is used for food in NIGERIA.


Sarcoma, Avian
Avian Sarcoma
Rous Sarcoma
Sarcoma, Rous

Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.


Ricinus communis
Castor Oil Plant
Ricinus
Castor Bean Plant

A plant genus of the family Euphorbiaceae. The seed of Ricinus communis is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other LECTINS.


Neurophysin I
Neurophysins
Oxytocin-Associated Neurophysin
Neurophysin II
Neurophysin III
Vasopressin-Associated Neurophysin

Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).


Adenovirus E4 Protein
Adenovirus E4F Protein
E4F Protein, Adenovirus
Adenovirus E4 Proteins
E4 Protein, Adenovirus

Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.


A plant genus of the family Asparagaceae. Members contain the cardiotonic PROSCILLARIDIN. The common name of squill is also used for DRIMIA.


Eupatorium rebaudianum
Stevia
Stevia rebaudiana
Sweetleaf

A plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).


Clinical Decision Support
Decision Support, Clinical
Decision Support Systems, Clinical
Clinical Decision Support Systems

Computer-based information systems used to integrate clinical and patient information and provide support for decision-making in patient care.


Plants, Medicinal
Herbs, Medicinal
Pharmaceutical Plants
Medicinal Herbs
Medicinal Plants
Healing Plants

Plants containing an active ingredient(s) with applications for medicinal purposes.


A gamma-cyclodextrin that functions as a reversal agent for the neuromuscular blocker ROCURONIUM BROMIDE.


Serotonin 3 Receptors
Receptor, Serotonin, 5-HT3A
Receptor, Serotonin, 5-HT3 Subunit B
Receptor, Serotonin, 5-HT3 Subunit D
Receptor, Serotonin, 5-HT3 Subunit A
Receptor, Serotonin, 5-HT3 Subunit E
Receptor, Serotonin, 5-HT3 Subunit C
5-Hydroxytryptamine-3 Receptor
Serotonin 3 Receptor
Receptor, Serotonin, 5-HT3B
Receptor, Serotonin, 5-HT3E
Receptor, Serotonin, 5-HT3D
Receptors, Serotonin, 5-HT3
Receptor, Serotonin 3
Receptor, Serotonin, 5-HT3C
5-HT3 Receptor

A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; POTASSIUM; and CALCIUM.


Diospyros digyna
Diospyros
Sapote, Black
Persimmon

A plant genus of the family EBENACEAE, order Ebenales, subclass Dilleniidae, class Magnoliopsida best known for the edible fruit and the antibacterial activity and compounds of the wood.


Vagus Nerve Disorders
Sensory Disorder, Vagus Nerve
Vagus Nerve Sensory Disorder
Motor Disorder, Vagus Nerve
Cranial Nerve X Diseases
Vagus Neuropathy
Vagus Nerve Diseases
Tenth Cranial Nerve Diseases
Vagus Nerve Motor Disorder
Pneumogastric Nerve Disorders

Diseases of the tenth cranial nerve, including brain stem lesions involving its nuclei (solitary, ambiguus, and dorsal motor), nerve fascicles, and intracranial and extracranial course. Clinical manifestations may include dysphagia, vocal cord weakness, and alterations of parasympathetic tone in the thorax and abdomen.


Sarothamnus scoparius
Broom
Cytisus
Cytisus scoparius
Broom, Scotch

A plant genus of the family FABACEAE that is sometimes called broom because of the shape of the plant. Members produce SPARTEINE.


Nicotine Tartrate
Nicotine
Nicotine Bitartrate

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.


SwissProt
Databases, Amino Acid Sequence
Protein Sequence Databases
Amino Acid Sequence Databases
SWISS-PROT
Protein Databases
Protein Structure Databases
Databases, Protein

Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.


Tylophora
Cynanchum indicum
Tylophora asthmatica
Tylophora indica
Asclepias asthmatica

A plant genus of the family ASCLEPIADACEAE. Members contain phenanthro-indolizidine alkaloids.


Infant Services, Health
Health Services, Child
Child Services, Health
Infant Health Services
Child Health Services
Services, Child Health
Health Services, Infant
Services, Infant Health

Organized services to provide health care for children.


Cone Opsins, Middle Wavelength-Sensitive

Photosensitive proteins expressed in the CONE PHOTORECEPTOR CELLS. They are the protein components of cone photopigments. Cone opsins are classified by their peak absorption wavelengths.


Apolipoprotein A2
Apo A-2
Proapolipoprotein A-II
Apolipoprotein A-II Isoproteins
Apo A-II Isoproteins
Apolipoprotein A-2
Apo A2
Apo AII
Pro-Apolipoprotein A-II
Pro-Apo A-II
ApoA-2
Apolipoprotein AII
Apolipoprotein A-II
Apo A-II
ApoA-II

The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.


Pulp Mummification
Pulp Gangrene, Dental
Pulp Necroses
Pulp Gangrene
Dental Pulp Necrosis
Pulp Autolysis, Dental
Pulp Necrosis
Pulp Necrosis, Dental
Necroses, Pulp
Necrosis, Dental Pulp
Dental Pulp Autolysis
Gangrene, Dental Pulp
Dental Pulp Gangrene
Autolysis, Dental Pulp

Drying and shriveling of the dental pulp due to dry gangrene. Historically this was a method used to remove devitalized pulp.


Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11alpha)-

Member of a bicyclic fatty acid class of compounds derived from PROSTAGLANDIN E1 involved in chloride channel gating.


Furadoine
Furantoin
Furadantine
Nitrofurantoin, Monohydrate
Nitrofurantoin Sodium Salt
Nitrofurantoin
Macrodantin
Furadonine
Furadantin

A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.


Consumer Participation
Community Participation
Community Involvement
Public Participation
Community Action
Consumer Involvement

Involvement of the users of services in the decision-making processes.


Spontaneous Postsynaptic Potentials
MEPPS
Miniature Postsynaptic Potentials
Miniature End Plate Potential
Miniature End Plate Potentials
Spontaneous End Plate Potentials

A subthreshold depolarizing postsynaptic potential generated at the NEUROMUSCULAR JUNCTION from a spontaneous release of neurotransmitters.


Noninvasive Prenatal Diagnosis
Noninvasive Prenatal Screening
Prenatal cfDNA Screening
Prenatal Cell-Free DNA Screening
Noninvasive Prenatal Testing

The analysis of cell-free fetal DNA or the DNA from fetal cells that are biopsied from a pregnant woman’s blood, to screen for genetically-determined traits and genetic abnormalities.


Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer

Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer

Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer

Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer

A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.


Canis rufus
Gray Wolf
Canis lupus
Ethiopian Wolf
Red Wolf
Canis simensis
Wolf
Wolves

Any of several large carnivorous mammals of the family CANIDAE that usually hunt in packs.


Finnish Sauna
Sauna
Sweat Lodge
Steam Bath
Baths, Finnish

A steam bath in a small wooden room where water is thrown on a stove or rocks to create the steam. A cool bath or shower completes the treatment.


Erythroid Progenitor Cells
Erythropoietic Progenitor Cells
Erythropoietic Stem Cells
CFU-E
BFU-E
Progenitor Cells, Erythropoietic
Stem Cells, Erythroid
Colony-Forming Units, Erythroid
Erythroid Precursor Cells
Burst-Forming Units, Erythroid

The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.


Oxalis corniculata
Oxalidaceae
Woodsorrel
Oxalis
Wood Sorrel
Creeping Wood Sorrel

Wood-sorrel family in the order Oxalidales. Some species of RUMEX (of the family POLYGONACEAE) also known by the common name of sorrels.


rap1 GTP-Binding Protein
rap1A GTP-Binding Protein
Krev-1 GTP-Binding Protein
rap1 GTP-Binding Proteins
rap1A Protein
Krev-1 Protein
smg p21 GTP-Binding Protein
smg p21A Protein
SMG p21A GTP-Binding Protein

A genetically related subfamily of RAP GTP-BINDING PROTEINS that share homology with RAS PROTEINS. They bind to Ras effectors but do not activate them, therefore they may antagonize the effects of RAS PROTEINS. This enzyme was formerly listed as EC 3.6.1.47.


Lesser Tubercle
Humerus
Greater Tubercle
Olecranon Fossi
Humeral Lesser Tuberosity
Olecranon Fossa
Humeral Greater Tuberosity

Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.


Eco RI
Deoxyribonuclease SsoI
Endodeoxyribonuclease ECoRI
Endonuclease RsrI
Endonuclease Eco159I
Deoxyribonuclease EcoRI
Eco-RI
EcoRI Endonuclease
Endonuclease Eco82I
Restriction Endonuclease RsrI
DNA Restriction Enzyme EcoRI
Endodeoxyribonuclease HsaI
HsaI Endonuclease
Endonuclease SsoI
Endonuclease EcoRI

One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/AATTC at the slash. EcoRI is from E coliRY13. Several isoschizomers have been identified. EC 3.1.21.-.


N-Propylajmaline
Prajmalium
Prajmaline
Prajmaline Bitartrate
Prajmalium Bitartrate
Neo-Gilurytmal

A derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent, but may cause liver damage.


Hemorrhagic Septicemia Virus, Viral
Novirhabdovirus
Viral hemorrhagic septicemia virus
Hirame rhabdovirus
Egtved virus

A genus in the family RHABDOVIRIDAE, infecting numerous species of fish with broad geographic distribution. The type species is INFECTIOUS HEMATOPOIETIC NECROSIS VIRUS.


A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS.


Poverty
Absolute Poverty
Indigents
Indigency
Low Income Population
Extreme Poverty
Low-Income Population

The inability to meet basic human needs, such as food, shelter, and avoidance of disease.


46,XX True Hermaphroditism, Sry-Positive

46,XX Gonadal Dysgenesis, Complete, Sry-Positive

Ovotesticular Disorders of Sex Development

Ovotesticular Disorder Of Sex Development

An historical term for conditions of sexual ambiguity in which the individual possesses gonadal tissues of both sexes.


Colicin B
Colicins E
Colicin E2
Precolicin E1
Colicin A
Colicin Ia
Colicin E8
Colicin K
Colicin Ib
Colicin HSC10
Colicin E
Colicin M
Colicin K-K235
Colicins E9
Colicin V
Colicines
Colicin E3
Colicins
Colicin N
Colicin E1

Bacteriocins elaborated by strains of Escherichia coli and related species. They are proteins or protein-lipopolysaccharide complexes lethal to other strains of the same species.


Transmission, Health Care Worker-Patient

Infectious Disease Transmission, Professional-to-Patient

The transmission of infectious disease or pathogens from health professional or health care worker to patients. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.


Heptavalent Pneumococcal Conjugate Vaccine

Seven-Valent Pneumococcal PS-Meningococcal OMPC Conjugate Vaccine

A pneumococcal vaccine which contains 7 pneumococcal serotypes (6B, 14, 19F, 23F, 18C, 4, 9V), each conjugated individually to the outer membrane protein complex of NEISSERIA MENINGITIDIS.


Community Periodontal Index of Treatment Needs

A numerical rating scale for classifying the periodontal status of a person or population with a single figure which takes into consideration prevalence as well as severity of the condition. It is based upon probe measurement of periodontal pockets and on gingival tissue status.


Nordefrin Tartrate, (R*,S*), (R*,R*) Isomer

4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol Tartrate, (R*,S*), (R*,R*)-Isomer

4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol Tartrate, (R*,R*), (R*,R*)-Isomer

Nordefrin Tartrate, (R*,R*), (R*,R*) Isomer

A norepinephrine derivative used as a vasoconstrictor agent.


Tectum Mesencephali
Lamina Quadrigemina
Commissure of Superior Colliculus
Commissure of Inferior Colliculus
Corpora Quadrigemina
Quadrigeminal Plate

The dorsal portion or roof of the midbrain which is composed of two pairs of bumps, the INFERIOR COLLICULI and the SUPERIOR COLLICULI. These four colliculi are also called the quadrigeminal bodies (TECTUM MESENCEPHALI). They are centers for visual sensorimotor integration.


Infant Walkers
Baby Swings
Infant Strollers
Baby Walkers
Infant Equipment
Cribs
High Chairs
Baby Strollers
Equipment, Infant
Infant Furniture
Infant Swings
Baby Equipment

Equipment and furniture used by infants and babies in the home, car, and play area.


Travel Sickness
Travel-Related Disease
Travel-Related Infectious Diseases
Travel-Associated Infectious Diseases
Travel-Related Infections
Travel-Related Illness
Travel-Related Sickness
Travel-Related Health Problems
Travel-Associated Infections


Arachnid Venoms
Araneid Venom
Tarantula Venoms
Arachnid Venom
Spider Venom
Spider Venoms
Araneid Venoms

Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.


Vaccinium uliginosum
Vaccinium angustifolium
Blueberry Plants
Vaccinium virgatum
Blueberry Plant
Blueberry
Vaccinium corymbosum
Blueberries
Vaccinium ashei

Several species of the genus Vaccinium which produce the edible blueberry fruit.


Alkaline Single-Cell Gel Electrophoresis Assay

A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.


Allylestrenol Gestanon Turinal Gestanin Allyloestrenol

A synthetic steroid with progestational activity.


Image-Guided Radiation Therapy
Target Organ Alignment, Radiotherapy
Radiotherapy, Image-Guided
Radiotherapy Target Organ Alignment

The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.


Total Anomalous Pulmonary Venous Return 1

An anomalous pulmonary venous return in which the right PULMONARY VEIN is not connected to the LEFT ATRIUM but to the INFERIOR VENA CAVA. Scimitar syndrome is named for the crescent- or Turkish sword-like shadow in the chest radiography and is often associated with hypoplasia of the right lung and right pulmonary artery, and dextroposition of the heart.


Amur Pike
Esox americanus
Esocidae
Northern Pike
Esox
Esox niger
Esox masquinongy
Esox reicherti
Chain Pickerel
Muskellunge
Pike
Esox lucius
Grass Pickerel


Chemokine CCL3
MIP-1alpha
Chemokine (C-C Motif) Ligand 3-Like 1
CCL3 Chemokine
CCL3L3 Chemokine
LD78alpha Chemokine
Chemokine CCL3L2
CCL3L2 Chemokine
CCL3L1 Chemokine
Small Inducible Cytokine A3
Chemokine (C-C Motif) Ligand 3-Like 2
Chemokine CCL3L1
Chemokine (C-C Motif) Ligand 3
Chemokine CCL3L3
BB-10010
Macrophage Inflammatory Protein 1-alpha
LD78beta Chemokine

A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES; and a variety of other immune cells. This chemokine is encoded by multiple genes.


Rho Guanine Nucleotide Exchange Factor 7

Rho Guanine Nucleotide Exchange Factor p115

Rho Guanine Nucleotide Exchange Factor (GEF) 1

Rho Guanine Nucleotide Exchange Factor 6

Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.


Acoustic Microscopy
Microscopy, Scanning Acoustic
Ultrasonographic Biomicroscopy
Ultrasound Biomicroscopy
Microscopy, Acoustic
Scanning Acoustic Microscopy
Ultrasonic Biomicroscopy

A method to provide microscopic images of living tissue by analyzing the reflection data of high-frequency ultrasound.


Solutions, Hemodialysis
Hemodialysates
Dialysis Solutions, Hemodialysis
Hemodialysis Solutions
Hemodialyzates

Solutions prepared for hemodialysis. The composition of the pre-dialysis solution may be varied in order to determine the effect of solvated metabolites on anoxia, malnutrition, acid-base balance, etc. Of principal interest are the effect of the choice of buffers (e.g., acetate or carbonate), the addition of cations (Na+, K+, Ca2+), and addition of carbohydrates (glucose).


Prestyloid Compartment of the Parapharyngeal Space

Poststyloid Compartment of the Parapharyngeal Space

The deep neck space near the PHARYNX located anterior to the ptyergomandibular raphe,  posterior to the prevertebral fascia, inferior to the SKULL BASE, and superior to the HYOID BONE. Prestyloid parapharyngeal space contains cranial nerves IX, X, XI, XII and internal JUGULAR VEIN and internal CAROTID ARTERY.  Poststyloid parapharyngeal space contains AURICULARTEMPORAL NERVE and MAXILLARY ARTERY and ascending pharyngeal artery.


Pityriasis Lichenoides et Varioliformis Acuta

A subgroup of PARAPSORIASIS itself divided into acute and chronic forms. The acute form is characterized by the abrupt onset of a generalized, reddish-brown, maculopapular eruption. Lesions may be vesicular, hemorrhagic, crusted, or necrotic. Histologically the disease is characterized by epidermal necrolysis. The chronic form shows milder skin changes with necrosis.


Supervised Injecting Centers
Syringe-Exchange Programs
Needle-Exchange Programs
Supervised Injecting Facilities

Organized services for exchange of sterile needles and syringes used for injections as a potential means of reducing the transmission of infectious diseases.


GABA Effect
GABA Agents
GABAergic Agent
GABAergic Effect
GABA Effects
GABAergic Effects
gamma-Aminobutyric Acid Agents
GABAergic Agents

Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.


An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential.


Tumoricidal Activity, Immunologic
Immunologic Tumoricidal Activities
Tumoricidal Activities, Immunologic
Cytotoxicity, Immunologic
Immunologic Tumoricidal Activity
Immunologic Cytotoxicity

The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.


A potent circulating form of ANP that is a 28-amino acid peptide. It derives from the (99-126) amino acids of prohormone gamma-ANP, also known as ANP (1-126).


Erythropoietic Protoporphyria
Protoporphyria, Erythropoietic
Heme Synthetase Deficiency
Erythrohepatic Protoporphyria
Ferrochelatase Deficiency

An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces.


A carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of HIV INFECTIONS.


Interprofessional Relations
Medical Etiquette
Etiquette, Medical

The reciprocal interaction of two or more professional individuals.


PAK2 Kinase
beta-PAK
p21-Activated Kinases
Oligophrenin-3
p65PAK Protein
p65(PAK)
PAK-1 Kinase
alpha-PAK
PAK-2 Kinase
PAK1 Kinase
p21-Activated Kinase 3
p21-Activated Kinase 2
PAK Kinases
PAK65
beta p21-Activated Kinase
Serine-Threonine-Protein Kinase PAK 3
PAK3 Kinase
p21-Activated Kinase 1
Serine-Threonine-Protein Kinase PAK 1
alpha p21-Activated Kinase
gamma-PAK

A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.


Nosema corneum
Vittaforma corneae
Vittaforma


Low Intensity Pulsed Ultrasound Radiation

Oscillating sound wave with a frequency higher than the upper limit of the human hearing range.


Fibrosis, Inflammatory Perianeurysmal
Inflammatory Perianeurysmal Fibrosis
Perianeurysmal Inflammatory Fibrosis
Inflammatory Fibrosis, Perianeurysmal
Periaortitis, Chronic
Fibrosis, Perianeurysmal Inflammatory
Retroperitoneal Fibrosis
Idiopathic Retroperitoneal Fibrosis
Ormond Disease
Ormond's Disease
Perianeurysmal Fibrosis, Inflammatory

A slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.


Type III Cystatins
Cystatin-Related Proteins
Type 3 Cystatins
Type 2 Cystatins
Type II Cystatins
Type 1 Cystatins
Cystatin Superfamily
Type I Cystatins
Cystatins
Stefins

Cystatins that occur primarily as intracellular proteins.


Formylmethionyl-Leucyl-Phenylalanine
N-formylmethionyl-leucyl-phenylalanine
Formylmethionylleucylphenylalanine
Formylmet-Leu-Phe
N-Formylmethionine Leucyl-Phenylalanine
F-Met-Leu-Phe
fMet-Leu-Phe
N-Formyl-Methionyl-Leucyl-Phenylalanine
Formylmethionyl Peptide
N-Formylated Peptide

A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.


Voltage-Clamp Technics
Patch-Clamp Technics
Patch-Clamp Techniques
Whole-Cell Recording
Voltage-Clamp Techniques

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.


Tumor Suppressor Genes
Growth Suppressor Genes
Genes, Growth Suppressor
Antioncogenes
Oncogenes, Recessive
Genes, Metastasis Suppressor
Genes, Onco-Suppressor
Tumor Suppressing Genes
Emerogenes
Genes, Cancer Suppressor
Genes, Tumor Suppressor
Cancer Suppressor Genes
Metastasis Suppressor Genes
Anti-Oncogenes

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.


Graves Ophthalmopathy
Thyroid-Associated Ophthalmopathy
Graves Orbitopathy
Ophthalmopathy, Thyroid-Associated
Thyroid-Associated Ophthalmopathies
Edematous Ophthalmopathy
Dysthyroid Ophthalmopathy
Congestive Ophthalmopathy
Ophthalmopathy, Infiltrative
Ophthalmopathies, Thyroid-Associated
Myopathic Ophthalmopathy

An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy.


Whortleberry
Vaccinium myrtillus
Bilberry
Sea Bilberry
Vaccinium bracteatum

A plant species of the family VACCINIUM.


Pluryl Benzide Esberizid Neo-NaClex Aprinox Bendrofluazide Berkozide Urizid Naturetin Benzide-M Naturine Bendroflumethiazide Centyl

A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)


SCF(beta-TrCP) Ubiquitin Ligase
SKP1-Cullin Ubiquitin Ligases
SCF(Fbw7) Ubiquitin Ligase
SKP Cullin F-Box Protein Ligases
SCF Ubiquitin Ligase
Skp1-Cullin-F-Box Proteins
Skp1-Cullin-1-F-box Ubiquitin Ligase

A subset of ubiquitin protein ligases that are formed by the association of a SKP DOMAIN PROTEIN, a CULLIN DOMAIN PROTEIN and a F-BOX DOMAIN PROTEIN.


SK&F D 39162
SK&F-39162
Auranofin
Ridaura
Ridauran
Crisinor

An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.


Gastrointestinal Agents
Gastric Drugs
Gastrointestinal Drugs
Gastric Agents
Digestants

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.


Generalized Myotonia of Becker
Thomsen Disease
Thomsens Disease
Myotonia, Generalized
Myotonia Congenita
Batten-Turner Congenital Myopathy
Thomsen's Disease
Myotonia Levior
Generalized Myotonia of Thomsen
Becker Generalized Myotonia
Myotonia Congenita, Autosomal Recessive
Myotonia, Generalized, Becker
Myotonia Congenita, Autosomal Dominant
Congenital Myotonia
Becker Disease
Myopathy, Congenital
Batten Turner Congenital Myopathy

Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulation and other movements. It is classified as Thomsen (autosomal dominant) or Becker (autosomal recessive) generalized myotonia mainly based on the inheritance pattern. Becker type is also clinically more severe. An autosomal dominant variant with milder symptoms and later onset is known as myotonia levior. Mutations in the voltage-dependent skeletal muscle chloride channel are associated with the disorders.


Nystagmus, Physiological
Nystagmus, Barany
Nystagmus, End-Position
Physiologic Nystagmus
Nystagmus, Positional
Nystagmus, Physiologic
Nystagmus, Post-Rotatory
Nystagmus, Caloric
Nystagmus, Barany's
Nystagmus, Thermal

Involuntary rhythmical movements of the eyes in the normal person. These can be naturally occurring as in end-position (end-point, end-stage, or deviational) nystagmus or induced by the optokinetic drum (NYSTAGMUS, OPTOKINETIC), caloric test, or a rotating chair.


A fluorinated ether that is used as a volatile anesthetic for maintenance of general anesthesia.


Echinococcus Granulosus Infection
Echinococcus Infection
Hydatid Cyst
Echinococcosis
Cystic Echinococcosis
Hydatidosis
Cysts, Hydatid
Hydatid Disease

An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.


nAChR alpha7 Subunit
alpha-Bungarotoxin Receptors
Receptor, alpha-Bungarotoxin
Nicotinic Acetylcholine Receptor alpha7
alpha7 Nicotinic Acetylcholine Receptor
alpha7nAChR

A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric α7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.


Feline Sarcoma Virus, Hardy-Zuckerman
Snyder-Theilen feline sarcoma virus
Sarcoma Virus, Feline, Hardy-Zuckerman
Hardy-Zuckerman feline sarcoma virus
Sarcoma Virus, Feline, Snyder-Theilen
Sarcoma Viruses, Feline
Feline Sarcoma Viruses
Feline Sarcoma Virus, Gardner-Arnstein
Sarcoma Virus, Feline, Gardner-Arnstein
Feline Sarcoma Virus, Snyder-Theilen
Gardner-Arnstein feline sarcoma virus

Species of GAMMARETROVIRUS isolated from fibrosarcoma in cats. The viruses are actually recombinant feline leukemia viruses (FeLV) where part of the genome has been replaced by cellular oncogenes. It is unique to individuals and not transmitted naturally to other cats. FeSVs are replication defective and require FeLV to reproduce.


Collagen Type-XI, alpha1 Chain
Collagen Type XI, alpha3 Subunit
Collagen Type-XI, alpha2 Chain
Collagen alpha1(XI)
Collagen Type XI, alpha2 Subunit
Collagen Type-XI, alpha3 Chain
Type XI Collagen
Type XI Procollagen
Procollagen Type XI
Collagen Type XI, alpha1 Subunit
Collagen alpha2(XI)
Collagen alpha3(XI)
Collagen Type XI

A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.


Heat-Shock Protein pp3
HSP20 Heat-Shock Protein
Heat-Shock Proteins 20
HSP20 Heat-Shock Proteins

A subfamily of small heat-shock proteins that are closely related to ALPHA B-CRYSTALLIN. Hsp20 heat-shock proteins can undergo PHOSPHORYLATION by CYCLIC GMP-DEPENDENT PROTEIN KINASES.


Glycine Agents
Glycine Effect
Glycine Effects
Glycinergic Agents
Glycinergic Agent

Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.


Medazepam
Rusedal
Nobrium
Medazepam AWD
Medazepam Monohydrochloride
Rudotel
Medazepam Hydrochloride
Ro 5-4556

A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM.


Anesthetic Agents
Anesthetic Drugs
Anesthetics
Anesthetic Effects
Anesthetic Effect

Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.


Meningioma
Papillary Meningioma
Sphenoid Wing Meningioma
Microcystic Meningioma
Posterior Fossa Meningioma
Intraorbital Meningioma
Psammomatous Meningioma
Clear Cell Meningioma
Fibrous Meningioma
Meningiomas, Multiple
Meningiomatosis
Hemangiopericytic Meningioma
Cerebral Convexity Meningioma
Transitional Meningioma
Angioblastic Meningioma
Parasagittal Meningioma
Olfactory Groove Meningioma
Hemangioblastic Meningioma
Spinal Meningioma
Malignant Meningioma
Meningotheliomatous Meningioma
Intracranial Meningioma
Angiomatous Meningioma
Benign Meningioma
Intraventricular Meningioma
Xanthomatous Meningioma
Secretory Meningioma

A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)


Fagara nitidum
Fagara xanthoxyloides
Fagara zanthoxyloides
Zanthoxylum
Zanthoxylum gilletii
Zanthoxylum rubescens
Fagara heitzii
Xanthoxylum cuspidatum
Fagara macrophylla
Xanthoxylum inerme
Zanthoxylum heitzii
Fagara monophyllum
Zanthoxylum monophyllum
Fagara coco
Fagara rubescens
Zanthoxylum rhetza
Zanthoxylum leprieurii
Zanthoxylum fagara
Zanthoxylum coco
Fagara mayu
Fagara cuspidata
Xanthoxylum
Zanthoxylum ailanthoides
Fagara tessmannii
Zanthoxylum nitidum
Fagara ailanthoides
Fagara boninensis
Zanthoxylum mayu
Fagara rhetza
Fagara leprieurii

A plant genus of the family RUTACEAE. Some members of Zanthoxylum are reclassified from ELEUTHEROCOCCUS, Melicope, and EVODIA. The twigs are used as dental brushing sticks (TOOTHBRUSHING).  Most plants that are called Fagara have been reclassified as Zanthoxylum, however some Fagara were reclassified  to MELICOPE (also in the Rutacea family) or to GLEDITSIA (a genus in the FABACEAE family).


Brain Injuries, Penetrating
Head Injuries, Penetrating
Craniocerebral Trauma, Penetrating
Head Trauma, Penetrating
Head Injuries, Penetrating, Missile
Head Injury, Penetrating
Missile Injuries, Penetrating, Head
Cranial Trauma, Penetrating
Penetrating Missile Injuries, Head

Head injuries which feature compromise of the skull and dura mater. These may result from gunshot wounds (WOUNDS, GUNSHOT), stab wounds (WOUNDS, STAB), and other forms of trauma.


mRNA Cleavage and Polyadenylation Factors

Factors that are involved in directing the cleavage and POLYADENYLATION of the of MESSENGER RNA near the site of the RNA 3' POLYADENYLATION SIGNALS.


The conic organs which usually give outlet to milk from the mammary glands.


Nuclear Volume, Cell
Cell Nucleus Volume
Cell Nuclear Size
Cell Nucleus Size
Nucleus Size, Cell
Nuclear Size, Cell
Nucleus Volume, Cell
Cell Nuclear Volume

The quantity of volume or surface area of a CELL NUCLEUS.


Aubergine
Eggplant
Solanum melongena
Brinjal

A plant species of the genus SOLANUM, family SOLANACEAE. The fruit is a large, egg-shaped berry, varying in color from dark purple to red, yellowish, or white. The leaves are large and ovate. The flowers are pendant, violet, and two inches across.


Pneumocytes
Type-II Pneumocytes
Type 2 Pneumocytes
Pneumocyte
Type 1 Pneumocytes
Alveolar Cells
Alveolar Epithelial Cells
Type-I Pneumocytes

Large flat epithelial cells that line the PULMONARY ALVEOLI and are involved in PULMONARY GAS EXCHANGE.


Phosphaturia
Diabetes, Phosphate
Hyperphosphaturia
Phosphate Diabetes
Hypophosphatemia, Familial
Familial Hypophosphatemia

An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.


Temporary Dental Filling
Dental Fillings, Temporary
Dental Prosthesis, Temporary
Restoration, Temporary Dental
Dental Restorations, Temporary
Fillings, Temporary Dental
Filling, Temporary Dental
Restorations, Temporary Dental
Dental Filling, Temporary
Temporary Dental Restorations
Dental Restoration, Temporary
Temporary Dental Fillings
Temporary Dental Restoration

A prosthesis or restoration placed for a limited period, from several days to several months, which is designed to seal the tooth and maintain its position until a permanent restoration (DENTAL RESTORATION, PERMANENT) will replace it. (From Jablonski, Dictionary of Dentistry, 1992)


Langendorff Perfused Isolated Heart Preparation

Method of isolation and maintenance of a working heart for various cardiac measurements. The model allows for the separation of cardiac and systemic variables in the denervated heart.


Metabolic Detoxication, Drug
Detoxification, Drug, Metabolic
Drug Detoxication, Metabolic
Metabolic Drug Inactivation
Metabolic Detoxification, Drug
Inactivation, Metabolic
Detoxication, Drug, Metabolic

Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.


Anencephaly
Anencephalia
Aprosencephaly
Hemicranial Anencephaly
Congenital Absence of Brain
Partial Anencephaly
Incomplete Anencephaly
Anencephalus
Absence of Brain, Congenital

A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247)


Post-Traumatic Encephalopathy
Chronic Post-Traumatic Encephalopathy
Chronic Post-Concussive Encephalopathy
Post-Concussive Encephalopathy
Traumatic Encephalopathy, Chronic
Chronic Encephalopathy, Post-Concussive
Encephalopathy, Post-Traumatic
Chronic Traumatic Encephalopathy
Encephalopathy, Post-Traumatic, Chronic
Encephalopathy, Post-Concussive

Degenerative brain disease linked to repetitive brain trauma. Progressive symptoms may include MEMORY LOSS; AGGRESSION; or DEPRESSION.


Lectins, Plant
Hemagglutinins, Plant
Phytagglutinins
Plant Agglutinins
Plant Lectins
Agglutinins, Plant

Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.


Proadrenomedullin N-Terminal 20 Peptide
ADM (1-52)
Proadrenomedullin (1-20)
ADM(1-52)
PAMP(1-20)NH2
Adrenomedullin (1-52)
Adrenomedullin

A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.


Bonamine
Bonine
D-Vert
Parachloramine
Meclozine
Histametizyn
Antivert
Meclizine Dihydrochloride
Meclizine Monohydrochloride
Meclizine Hydrochloride
Agyrax
Ru-Vert-M
Chiclida
Meclizine

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.


Gonadotropins, Equine
PMS Gonadotropins
PMSG (Gonadotropins)
Pregnant Mare Serum Gonadotropins

Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.


Caseinolytic Peptidase B Protein Homolog

An ATP-dependent protease found in prokaryotes, CHLOROPLASTS, and MITOCHONDRIA. It is a soluble multisubunit complex that plays a role in the degradation of many abnormal proteins.


Hemifacial Microsomia with Radial Defects

Goldenhar Syndrome with Ipsilateral Radial Defect

Oculoauriculovertebral Spectrum with Radial Defect

First and Second Branchial Arch Syndrome

First and Second Pharyngeal Arch Syndromes

Mandibulofacial dysostosis with congenital eyelid dermoids.


Acute Renal Failure
Acute Kidney Insufficiency
Acute Renal Injury
Acute Kidney Injury
Renal Insufficiency, Acute
Kidney Failure, Acute
Acute Kidney Failure
Renal Failure, Acute
Kidney Insufficiency, Acute
Acute Renal Insufficiency

Conditions in which the function of KIDNEYS deteriorates suddenly in a matter of days or even hours. It is characterized by the sudden drop in GLOMERULAR FILTRATION RATE.


Euterpe precatoria
Euterpe oleracea Mart.
Euterpe oleracea
Acai Berries
Euterpe
Assai Palm Berries
Assai Palm
Açai Berries
Euterpe edulis

The fleshy simple fruit of the palm plant EUTERPE.


Parapsychology
Psychical Research
Extrasensory Perception
Psychic Research
Clairvoyance

Branch of psychology that deals with paranormal behavior and events such as telepathy, precognition, and clairvoyance, which are not explicable by present day "natural laws".


X-Rays, Nuclear
Nuclear X-Rays
Gamma Rays
Radiation, Gamma
Gamma Radiation

Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.


A plant genus of the family KRAMERIACEAE. Members contain proanthocyanidins.


Ovine adenovirus D
Deer adenovirus
Bovine adenovirus D
Atadenovirus
Egg drop syndrome virus
Ovine adenovirus 7
Duck adenovirus A


Hydrocodone Tartrate (1:1), Hydrate (2:5)

Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.


An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.


Melanoma Differentiation-Associated Protein 9

Intracellular signaling adaptor proteins that play a role in the coupling of SYNDECANS to CYTOSKELETAL PROTEINS.


Nicotine Inhalant
Nicotine Patch
Nicotine Nasal Spray
Nicotine Delivery Devices
Nicotine Replacement Products
Tobacco Use Cessation Devices
Nicotine Lozenge
Tobacco Use Cessation Products
Nicotine Lozenges
Nicotine Polacrilex
Smoking Cessation Products
Nicotine Transdermal Patch

Non-medical products used to aid in ending a SMOKING habit.


A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.


Injectable form of risperidone that is encapsulated in MICROSPHERES.


Cortical Phase Desynchronization
Cortical Desynchronization
Cortical Phase Synchronization
Cortical Synchronization

EEG phase synchronization of the cortical brain region (CEREBRAL CORTEX).


Dihydrotachysterol
Dihydrotachysterin
Calcamine
AT 10
AT-10
Tachystin

A VITAMIN D that can be regarded as a reduction product of vitamin D2.


EMB-Hefa
Miambutol
EMB-Fatol
Etambutol Llorente
Myambutol
Etibi
Ethambutol Hydrochloride
Ethambutol
Dexambutol

An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)


Ig Framework Region
Immunoglobulin V
Immunoglobulin Variable Region
Immunoglobulin Framework Region
Fv Antibody Fragments
Fv Fragments
Variable Region, Immunoglobulin
Immunoglobulin Fv Fragments
Ig Variable Region
Variable Region, Ig
Framework Region, Immunoglobulin

The paired immunoglobulin fragments composed of the variable domains of the heavy and light chains.


Dormodor
Flurazepam Mono-Perchlorate
Flurazepam
Flurazepam Dihydrochloride
Dalmadorm
Staurodorm
Apo-Flurazepam
Flurazepam Hydrochloride
Dalmane
Flurazepam Monohydrochloride

A benzodiazepine derivative used mainly as a hypnotic.


Glutathione Transferase P1-1
GSTP1 Glutathione D-Transferase
GST Class-phi
Glutathione S-Transferase pi

A glutathione transferase that catalyzes the conjugation of electrophilic substrates to GLUTATHIONE. This enzyme has been shown to provide cellular protection against redox-mediated damage by FREE RADICALS.


Base Sequence Homology
Nucleic Acid Sequence Homology
Sequence Homology, Nucleic Acid
Homologous Sequences, Nucleic Acid
Homologs, Nucleic Acid Sequence
Sequence Homology, Base
Homology, Nucleic Acid Sequence
Nucleic Acid Sequence Homologs
Homology, Base Sequence

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.


Hypoxia-Ischemia, Cerebral
Anoxia-Ischemia, Cerebral
Cerebral Ischemia-Anoxia
Anoxia-Ischemia, Brain
Brain Ischemia-Hypoxia
Encephalopathy, Hypoxic-Ischemic
Brain Hypoxia-Ischemia
Ischemia-Anoxia, Brain
Hypoxic-Ischemic Encephalopathy
Cerebral Ischemia-Hypoxia
Cerebral Hypoxia-Ischemia
Ischemia-Hypoxia, Cerebral
Anoxic-Ischemic Encephalopathy
Ischemia-Anoxia, Cerebral
Encephalopathy, Anoxic-Ischemic
Ischemia-Hypoxia, Brain
Brain Anoxia-Ischemia
Brain Ischemia-Anoxia
Cerebral Anoxia-Ischemia
Ischemic-Hypoxic Encephalopathy
Hypoxia-Ischemia, Brain

A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.


Condition, Preneoplastic
Preneoplastic Conditions
Preneoplastic Condition
Precancerous Conditions
Conditions, Preneoplastic

Pathological conditions that tend eventually to become malignant.


Utilization and Quality Control Peer Review Organizations

Professional Standards Review Organizations

Organizations representing designated geographic areas which have contracts under the PRO program to review the medical necessity, appropriateness, quality, and cost-effectiveness of care received by Medicare beneficiaries. Peer Review Improvement Act, PL 97-248, 1982.


Glioblastoma-Derived T-Cell Suppressor Factor

Suppressor Factor, T-Cell, Glioblastoma-Derived

Transforming Growth Factor beta 2 Latency Associated Peptide

A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.


Cystine Disulfide Reducing Agents
Cystine Disulfide Reducers
Cystine Depleting Agents

Compounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS.


p45 SKP2
Skp1 Protein
S-Phase Kinase Associated Protein
p19(SKP1) Protein
SCF(SKP2)
p45(SKP2) Protein
Skp Domain Protein
Skp1 Proteins
Skp2 Proteins
Skp Domain Proteins
S-Phase Kinase-Associated Proteins
p45(SKP2)
Skp2 Protein
p19 SKP1

A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.


Ledermycin
Declomycin
Demeclocycline, Calcium (1:1) Salt
Demeclocycline, 4-epimer
Demeclocycline
Demethylchlortetracycline
Demeclocycline, Calcium (1:2) Salt
Demeclocycline Hydrochloride
Lédermycine
Demeclocycline Monohydrochloride

A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.


Clobex
Cormax
Clobetasol
Clobetasol 17-Propionate
Dermovate
Temovate
OLUX
Clobetasol Propionate
Clofenazon
Embeline
Embeline E

This is the form in trademark preparations.


Cyclic Nucleotide Phosphodiesterases, Type 1A

Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase

Cyclic Nucleotide Phosphodiesterase PDE1 Family

Cyclic Nucleotide Phosphodiesterases, Type 1B

Cyclic Nucleotide Phosphodiesterases, Type 1C

Cyclic Nucleotide Phosphodiesterases, Type I

Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase

A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.


Killer Cell Lectin-Like Receptor Subfamily D, Member 1

NK Cell Lectin-Like Receptor Subfamily D, Member 1

A subclass of NK cell lectin-like receptors that associates with a variety of members of NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY C to form heterodimeric receptors for HLA-E antigen.


Geophysical Processes
Geological Phenomenon
Geophysical Process
Geological Concepts
Geophysical Phenomena
Geological Phenomena
Geological Processes
Geological Process

Structures, properties, and processes involving the inanimate matter of Earth.


Polygala
Polygala sibirica
Seneca Snakeroot
Polygala senega
Polygala tenuifolia
Snakeroot, Seneca

A plant genus of the family POLYGALACEAE that contains onjisaponins, xanthones, pyrones, and benzophenones. The name is similar to other snakeroots such as ASARUM; SANICULA; ARISTOLOCHIA; AGERATINA; and others.


Gonadal Dysgenesis, 46, XY
Sex Reversal, Gonadal, 46, XY
Complete Gonadal Dysgenesis, 46, XY
Pure Gonadal Dysgenesis, 46, XY
Gonadal Dysgenesis, 46,XY
46, XY Gonadal Sex Reversal
Swyer Syndrome
XY Pure Gonadal Dysgenesis
46,XY Complete Gonadal Dysgenesis
46, XY Gonadal Dysgenesis
Pure Gonadal Dysgenesis 46,XY

Defects in the SEX DETERMINATION PROCESS in 46, XY individuals that result in abnormal gonadal development and deficiencies in TESTOSTERONE and subsequently ANTIMULLERIAN HORMONE or other factors required for normal male sex development. This leads to the development of female phenotypes (male to female sex reversal), normal to tall stature, and bilateral streak or dysgenic gonads which are susceptible to GONADAL TISSUE NEOPLASMS. An XY gonadal dysgenesis is associated with structural abnormalities on the Y CHROMOSOME, a mutation in the GENE, SRY, or a mutation in other autosomal genes that are involved in sex determination.


Amphetamine Addiction
Amphetamine Dependence
Amphetamine-Related Disorders
Amphetamine Abuse

Disorders related or resulting from use of amphetamines.


Current Procedural Terminology Codes
Current Procedural Terminology
CPT Codes

Descriptive terms and identifying codes for reporting medical services and procedures performed by PHYSICIANS. It is produced by the AMERICAN MEDICAL ASSOCIATION and used in insurance claim reporting for MEDICARE; MEDICAID; and private health insurance programs (From CPT 2002).


Cancer of Tongue
Tongue Cancer
Cancer of the Tongue
Neoplasms, Tongue
Tongue Neoplasms


Uveoretinal Coloboma
Coloboma, Ocular
Coloboma
Coloboma Of Iris, Choroid, And Retina
Ocular Coloboma
Coloboma, Uveoretinal

Congenital anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation.


Measurements of the electrical activities of specific areas of the heart, taken from inside the ESOPHAGUS.


Polstigmine
Neostigmine Bromide
Syntostigmine
Neostigmine
Prostigmine
Proserine
Prozerin
Neostigmine Methylsulfate
Synstigmin
Prostigmin

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.


Pro-Hepcidin
Hepcidin
Liver-Expressed Antimicrobial Peptide
Hepcidins
Prohepcidin

Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.


A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.


Diiodohydroxyquin Entero-Diyod Diquinol Diiodohydroxyquinoline Yodoxin Diodoquin Iodoquinol Sebaquin Diodoxyquinoline Diiodoquin Entodiba

One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.


Metapneumovirus, Avian
Human Metapneumovirus
Metapneumovirus
Rhinotracheitis Virus, Turkey
Avian Metapneumovirus
Avian Pneumovirus
Metapneumovirus, Human
Pneumovirus, Avian
Turkey Rhinotracheitis Virus

A METAPNEUMOVIRUS isolated from young children with acute RESPIRATORY TRACT INFECTIONS.


Adaptation, Marginal, Dental
Marginal Adaptation, Dental
Dental Internal Adaptation
Dental Marginal Adaptation
Dental Internal Fit

The degree of approximation or fit of filling material or dental prosthetic to the tooth surface. A close marginal adaptation and seal at the interface is important for successful dental restorations.


Hepatoma, Morris
Hepatomas, Experimental
Hepatoma, Experimental
Experimental Hepatomas
Hepatoma, Novikoff
Experimental Liver Neoplasms
Neoplasms, Experimental Liver
Experimental Hepatoma
Liver Neoplasms, Experimental

Experimentally induced tumors of the LIVER.


Preprorenin
Prorenin
Angiotensin-Forming Enzyme
Cryorenin
Pre-Prorenin
Renin
Big Renin
Angiotensinogenase
Inactive Renin

A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.


Histiocytoma, Cutaneous
Dermatofibroma
Histiocytoma, Benign Fibrous
Angioma, Sclerosing
Benign Fibrous Histiocytoma
Hemangioma, Sclerosing
Histiocytoma, Fibrous

A slowly growing benign skin nodule consisting of poorly demarcated cellular fibrous tissue enclosing collapsed CAPILLARIES with scattered HEMOSIDERIN-pigmented and lipid MACROPHAGES. They are common, usually about 1 cm in diameter and occur in the DERMIS. (From Stedman, 25th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1356)


Microangiopathic Hemolytic Anemia, Congenital

Thrombotic Thrombocytopenic Purpura, Familial

Congenital Thrombotic Thrombocytopenic Purpura

Familial Thrombotic Thrombocytopenic Purpura

Familial Thrombotic Thrombocytopenia Purpura

Thrombotic Thrombocytopenic Purpura, Congenital

An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases.


Omsk hemorrhagic fever virus
Viruses, Tick-Borne Encephalitis
Tick-Borne Encephalitis Viruses
Powassan virus
Langat virus
Tick-Borne Encephalitis Virus
Alkhurma virus (ALKV)
Al-Khurma Hemorrhagic Fever Virus
Louping ill virus
Al-Khurma virus
Encephalitis Viruses, Tick-Borne
Hemorrhagic Fever Virus, Omsk
Al-Khurma virus (ALKV)
Kyasanur Forest disease virus
Encephalitis Virus, Tick-Borne
Alkhurma virus
Alkhurma Hemorrhagic Fever Virus

A subgroup of the genus FLAVIVIRUS that causes encephalitis and hemorrhagic fevers and is found in eastern and western Europe and the former Soviet Union. It is transmitted by TICKS and there is an associated milk-borne transmission from viremic cattle, goats, and sheep.


Ergometrin
Ergometrine
Ergonovine Maleate
Ergobasin
Ergotrate
Ergometrine Maleate
Ergonovine

An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.


GAR-936
9-(tert-Butylglycylamido)minocycline
GAR 936
Tygacil
Tigecycline
TBG-MINO

A tetracycline derivative that acts as a protein synthesis inhibitor. It is used as an antibacterial agent for the systemic treatment of complicated skin and intra-abdominal infections. It is also used for the treatment of community-acquired pneumonia.


Low Bone Mineral Density
Metabolic Bone Diseases
Osteopenia
Bone Diseases, Metabolic
Low Bone Density

Diseases that affect the METABOLIC PROCESSES of BONE TISSUE.


Vidisic PVP Ophtiole
Duratears Free
Crospovidone
Protagent
Polvidone
Lagrifilm
Polyvidon
Enterodes
Povidone
Wet-Comod
Lacri-Stulln
Polyplasdone XL
Polyvinylpyrrolidone
Protagens
Hypotears
Arufil
Plasdone
Kollidon
Dulcilarmes
Unifluid
Liquifilm Lagrimas
PVP 40
Oculotect
Periston
Bolinan
Bolinan 40
Enterodez
Nutrivisc
Povidone, Unspecified
Vidirakt S mit PVP
Lacophtal

A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.


Receptors, Corticoid II
Receptors, Glucocorticoid
Receptors, Corticoid Type II
Glucocorticoid Receptors
Corticoid II Receptor
Receptors, Glucocorticoids
Corticoid Type II Receptors
Glucocorticoid Receptor

Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.


Malocclusion, Angle Class II, Division 1

Malocclusion, Angle Class II, Division 2

Malocclusion in which the mandible is posterior to the maxilla as reflected by the relationship of the first permanent molar (distoclusion).


European Ash
Fraxinus ornus
Flowering Ash
Ash Tree
Ash, Common
Fraxinus excelsior
Fraxinus

A plant genus of the family OLEACEAE. Members contain secoiridoid glucosides.


Kv4.3L Potassium Channel
KCND2 Potassium Channel
Kv4.3 Potassium Channel
KCND1 Potassium Channel
Kv4.2 Potassium Channel
Shal Potassium Channels
Kv4 Potassium Channels
Kv4.1 Potassium Channel
KCND3 Potassium Channel

A shaker subfamily of potassium channels that participate in transient outward potassium currents by activating at subthreshold MEMBRANE POTENTIALS, inactivating rapidly, and recovering from inactivation quickly.


Ceratostigma
Cerato
Plumbago zeylanica
Plumbago
Plumbaginaceae
Limonium
Armeria maritima

A plant genus of the family PLUMBAGINACEAE that contains plumbagin.


Nutrition, Home Parenteral
Home Parenteral Feeding
Parenteral Feeding, Home
Parenteral Nutrition, Home
Home Parenteral Nutrition

The at-home administering of nutrients for assimilation and utilization by a patient who cannot maintain adequate nutrition by enteral feeding alone. Nutrients are administered via a route other than the alimentary canal (e.g., intravenously, subcutaneously).


Suipoxvirus
Swinepox virus
Swine Pox Virus

A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, containing one species, swinepox virus.


Cross-Over Design
Crossover Design
Crossover Trials
Cross-Over Studies
Crossover Studies
Cross-Over Trials

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)


Bristlegrass
Setaria Plant
Millet, Italian
Italian Millet
Chaetochloa italica
Millet, German
Setaria italica
Millet, Foxtail

A plant genus of the family POACEAE. The small pointed seeds are grown for hay in North America and western Europe and important as food in China and other Asian countries.


Polycomb Group (PcG) Multiprotein PRC1-Like Complex

A family of proteins that play a role in CHROMATIN REMODELING. They are best known for silencing HOX GENES and the regulation of EPIGENETIC PROCESSES.


Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein

An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.


Experimental Medicine
Biomedical Research
Investigational Medicine
Investigative Medicine
Medical Research
Research, Medical
Research, Biomedical

The scientific investigation of medical problems by experimentation.


Nucleotide Sequence
Base Sequence
DNA Sequence
DNA Sequences
RNA Sequence

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.


Implantable Stimulation Electrodes
Implanted Electrodes
Implanted Stimulation Electrodes
Electrodes, Implanted
Implantable Electrodes

Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.


Selenic Acid, Disodium Salt, Decahydrate

Selenic Acid, Disodium Salt, 75Se-Labeled

A strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.


Tasedan D40TA ProSom D-40TA Estazolam Nuctalon

A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.


A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, DYSCALCULIA, and right-left disorientation. The syndrome may be developmental or acquired. Acquired Gerstmann syndrome is associated with lesions in the dominant (usually left) PARIETAL LOBE which involve the angular gyrus or subjacent white matter. (From Adams et al., Principles of Neurology, 6th ed, p457)


Eugenia
Brazilian Cherry Tree
Surinam Cherry Tree
Pitanga
Euginia uniflora

A genus in the family Myrtaceae sometimes known as "stoppers" in FOLK MEDICINE. Many species of the genus SYZYGIUM have synonymous names that begin with the Eugenia genus name.


Alpha Rays
Alpha Radiation
Radiation, Alpha
Alpha Particles


Neurodegeneration With Brain Iron Accumulation 2A

A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)


Low Back Pain, Postural
Recurrent Low Back Pain
Low Back Pain, Posterior Compartment
Low Back Ache
Mechanical Low Back Pain
Lower Back Pain
Low Back Pain, Mechanical
Lumbago
Low Back Pain
Low Back Pain, Recurrent
Low Backache
Postural Low Back Pain

Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.


Concomitant Radiochemotherapy
Concurrent Chemoradiotherapy
Concomitant Chemoradiotherapy
Radiochemotherapy
Chemoradiotherapy
Synchronous Chemoradiotherapy
Concurrent Radiochemotherapy

Treatment that combines chemotherapy with radiotherapy.


Pneumoencephalography
Cisternography, Pneumoencephalographic
Pneumoencephalographic Cisternography

Radiographic visualization of the cerebral ventricles by injection of air or other gas.


A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.


Sterecyt Prednimustine Leo-1031 NSC-134087 Stéréocyt Stereocyt

Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.


(3 alpha-Tropanyl)-1H-indole-3-carboxylic Acid Ester

An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.


Human Papillomavirus Vaccines
Human Papilloma Virus Vaccines
Papillomavirus Vaccines
HPV Vaccines

Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.


Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O.


A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of EPILEPSY, for refractory PARTIAL SEIZURES.


Constitutive Photomorphogenesis 9 Signalosome

Constitutive Photomorphogenesis 9 Signalsome

A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.


Radiography, Digital
Radiographic Image Enhancement
Image Enhancement, Radiographic
Digital Radiography

Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed.


Flavobacterium meningosepticum
Chryseobacterium
Chryseobacterium meningosepticum

A genus of aerobic, gram-negative bacteria in the family FLAVOBACTERIACEAE. Many of its species were formerly in the genus FLAVOBACTERIUM.


A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.


Cancer of Endometrium
Endometrial Cancer
Neoplasms, Endometrial
Endometrium Cancer
Endometrial Carcinoma
Cancer of the Endometrium
Carcinoma of Endometrium
Endometrial Neoplasms

Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.


Lactogen Hormone, Placental
HPL (Human Placental Lactogen)
PAPP-D
Mammotropic Hormone, Placental
Somatomammotropin, Chorionic
Human Placental Lactogen
Placental Luteotropin
Pregnancy-Associated Plasma Protein D
Choriomammotrophin
Choriomammotropin
Placental Lactogen
HCS (Human Chorionic Somatomammotropin)
Chorionic Somatomammotropin, Human

A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.


Interleukin-1 Receptor-Associated Kinase 2

Interleukin-1 Receptor-Associated Kinase 1

Interleukin-1 Receptor-Associated Kinase 4

Interleukin-1 Receptor-Associated Kinase 3

A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.


IL-1 beta Convertase
IL-1 beta-Converting Enzyme
Pro-Caspase-1
Caspase 1
Interleukin-1 Converting Enzyme
Interleukin-1beta Converting Enzyme
Procaspase-1
CASP1 Caspase
ICE Protease
IL1BC Enzyme

A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.


Populations at Risk
Risk Factors
Population at Risk

An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.


Bonding, Dental
Curing, Dental Cement
Dental Bonding
Cure of Orthodontic Adhesives

The process of hardening the DENTAL CEMENTS.


Tumor Necrosis Factor Ligand Superfamily Member 1

A tumor necrosis factor family member that is released by activated LYMPHOCYTES. Soluble lymphotoxin is specific for TUMOR NECROSIS FACTOR RECEPTOR TYPE I; TUMOR NECROSIS FACTOR RECEPTOR TYPE II; and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14. Lymphotoxin-alpha can form a membrane-bound heterodimer with LYMPHOTOXIN-BETA that has specificity for the LYMPHOTOXIN BETA RECEPTOR.


Lysosomal alpha-Glucosidase
alpha-Glucosidase
alpha-Glucosidases
Maltase-Glucoamylase
Maltases
Acid Maltase
Neutral Maltase
Neutral alpha-Glucosidase

Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.


Stabbing Headache
Benign Cough Headache
Primary Exertional Headache
Alarm Clock Headache
Hypnic Headache
Hypnic Headache Syndrome
Ice-Pick Headache
Primary Stabbing Headache
Headache, Thunderclap
Primary Cough Headache
Cough Headache
Primary Thunderclap Headache
Benign Exertional Headache
Thunderclap Headache
Primary Headache Disorders
Headache Disorders, Primary

A primary headache disorder which occurs exclusively during sleep and regularly awakes patients at a consistent time of night.


Ischemic Myelopathy
Spinal Cord Ischemia
Experimental Spinal Cord Ischemia
Spinal Cord Ischemia, Experimental

Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.


Nasal Cannulae
Nasal Cannula
Cannulae
Cannula

Short, hollow cylinders or tubes for insertion into a canal, vessel, or body cavity.


Reproductive Physiological Phenomena
Reproductive Physiological Concepts
Reproductive Physiological Processes
Reproductive Physiological Phenomenon
Reproductive Physiological Process
Reproductive Physiologic Concepts

Physiological processes, factors, properties and characteristics pertaining to REPRODUCTION.


Aneurysm, Bacterial
Mycotic Aneurysm
Aneurysm, Mycotic
Aneurysm, Infected
Infected Aneurysm
Fungal Aneurysm
Bacterial Aneurysms
Bacterial Aneurysm

Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.


Asymmetric Stem Cell Division
Asymmetric Cell Division
Asymmetric Stem Cell Differentiation

Type of cell division of stem cells resulting in one daughter cell identical to the original stem cell and another non-stem daughter cell. This type of cell differentiation is achieved by asymmetrical segregation of cell fate determinants (see CELL POLARITY) and orientation of the MITOTIC SPINDLE in the context of intrinsic and extrinsic cues (STEM CELL NICHE).


Infradian Rhythm
Infradian Cycles
Infradian Cycle

A biological rhythm with a period longer than 24 hours.


Internal Mammary Artery
Internal Thoracic Artery
Mammary Arteries

Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.


Huckleberries
Huckleberry Plant
Huckleberry

Several plant species of the genus VACCINIUM known for the edible huckleberry fruit.


A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.


Guanidinium
Guanidine Monohydroiodine
Guanidine Monohydrobromide
Guanidine Sulfate (2:1)
Guanidine Phosphate
Guanidinium Chloride
Guanidine Nitrate
Guanidine Monohydrate
Guanidine Sulfite (1:1)
Guanidine Sulfate
Guanidium Chloride
Guanidine Monohydrochloride
Guanidine Hydrochloride
Guanidine Sulfate (1:1)
Guanidine

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.


Aritmina
Gilurtymal
Ajmaline
Rauverid
Ajmaline Hydrochloride
Serenol
Wolfina
Tachmalin
Cardiorythmine

An alkaloid found in the root of RAUWOLFIA SERPENTINA, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.


Sudafed
Isoephedrine
Pseudoephedrine
Pseudoephedrine HCl
Pseudoephedrine Hydrochloride
Threo Isomer of Ephedrine


Gymnotiformes Gymnotid Gymnotidae Eigenmannia


Orexin Receptors
Orexin A Receptor
Hypocretin Receptors 2
Orexin-B Receptor
OX1 Receptors
Hypocretin-2 Receptor
Hypocretin Receptor 2
Orexin Receptor Type 1
Orexin Receptor 2
HCRT Receptor 2
Orexin-A Receptors
Receptor 2, Hypocretin
Hypocretin-1 Receptor
Receptor, Orexin-B
HCTR2 Protein
Receptor, Orexin-A
Orexin Receptor Type 2
Orexin-A Receptor
Orexin B Receptor
HCRT Receptor 1
Orexin-B Receptors
OX2 Receptors
Hypocretin Receptors

G-protein-coupled NEUROPEPTIDE RECEPTORS that have specificity for OREXINS and play a role in appetite control, and sleep-wake cycles. Two principle receptor types exist, each having a specificity for OREXIN A and OREXIN B peptide subtypes.


Red Blood Cell Membrane Sialoglycoprotein

Ss Erythrocyte Membrane Sialoglycoproteins

The major sialoglycoprotein of human erythrocyte membranes. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.


Papillon-Leage and Psaume Syndrome
Oral-Facial-Digital Syndrome, Type II
Orofaciodigital Syndromes
Orofaciodigital Syndrome II
Oral-Facial-Digital Syndrome
Oro-Facio-Digital Syndrome
Oral-Facial-Digital Syndrome, Type I
Dysplasia Linguofacialis
Mohr Syndrome
Orodigitofacial Dysostosis
Orodigitofacial Syndrome
Orofaciodigital Syndrome I
Gorlin-Psaume Syndrome
Orofaciodigital Syndrome

Two syndromes of oral, facial, and digital malformations. Type I (Papillon-Leage and Psaume syndrome, Gorlin-Psaume syndrome) is inherited as an X-linked dominant trait and is found only in females and XXY males. Type II (Mohr syndrome) is inherited as an autosomal recessive trait.


Infections, Circovirus
Infections, Circoviridae
Circoviridae Infections
Circovirus Infections

Virus diseases caused by the CIRCOVIRIDAE.


Syprine
Trien
Triethylenetetramine
Trientine Dihydrochloride
Trientine Hydrochloride
Trientine

An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.