Transcriptase
DNA-Directed RNA Polymerases
RNA Polymerase
DNA-Directed RNA Polymerase
RNA Polymerases
Transcriptases
DNA-Dependent RNA Polymerases

Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).


Derivatives of tartronic acid (the structural formula (COOH)CHOH(COOH)) including its salts and esters.


A plant genus of the family ROSACEAE. Members contain TANNINS.


C5a Complement
Complement 5a
Complement Component 5a
Complement C5a

The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.


Dental Sealants
Sealants, Dental
Pit and Fissure Sealants
Sealants, Tooth
Pit Fissure Sealants
Fissure Sealants

Agents used to occlude dental enamel pits and fissures in the prevention of dental caries.


Guanylate Cyclase C Agonists
Guanylyl Cyclase C Agonists

Compunds that bind to and activate GUANYLYL CYCLASE-C RECEPTORS.


Substances released by PLANTS such as PLANT GUMS and PLANT RESINS.


Milk that is produced by HUMAN MAMMARY GLANDS.


ST3 Matrix Metalloproteinase
MMP-11 Metalloproteinase
Stromelysin 3
Matrix Metalloproteinase 11
MMP11 Metalloproteinase

A secreted matrix metalloproteinase that is believed to play a role in EXTRACELLULAR MATRIX remodeling and cell fate determination during normal and pathological processes. Matrix metalloproteinase 11 was originally isolated in primary BREAST NEOPLASMS and may be involved in the process of tumorigenesis.


Receptors, Purinergic P2X
P2X Purinoceptor
P2X Purinoceptors

A subclass of purinergic P2 receptors that signal by means of a ligand-gated ion channel. They are comprised of three P2X subunits which can be identical (homotrimeric form) or dissimilar (heterotrimeric form).


Histone H5
Histone H3
Histone H2a
Histones
Histone H3.3
Histone H7
Histone H1(s)
Histone H1
Histone H4
Histone
Histone H2b

Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.


Phenylalanine-tRNA Ligase
Phenylalanyl T RNA Synthetase
Phenylalanyl-tRNA Synthetase
Phe-tRNA Ligase

An enzyme that activates phenylalanine with its specific transfer RNA. EC 6.1.1.20.


Injuries to the part of the upper limb of the body between the wrist and elbow.


Glucose Transport Proteins, Facilitative

A family of monosaccharide transport proteins characterized by 12 membrane spanning helices. They facilitate passive diffusion of GLUCOSE across the CELL MEMBRANE.


Transferrin-Binding Protein A
Tbp1 Transferrin-Binding Protein
TbpA Transferrin-Binding Protein

A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.


Cultural Diversity
Multiculturalism
Cultural Pluralism
Pluralism

The presence of multiple value systems within or among societies. (Bioethics Thesaurus)


An enzyme that catalyzes the replication of the RNA of coliphage Q beta. EC 2.7.7.-.


Ambidexterity
Functional Laterality
Mirror Writing
Behavioral Laterality
Handedness
Laterality of Motor Control

Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.


Korean Traditional Medicine
Medicine, Korean Traditional
Traditional Medicine, Korea

Medical practice or discipline that is based on the knowledge, cultures, and beliefs of the people of KOREA.


High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.


Toeing In
In-Toeing
Metatarsus Adductovarus
Pigeon Toed
Metatarsal Varus
Pigeon-Toed
Metatarsus Adductus
Metatarsus Varus

A foot anomaly in which the forefoot (METATARSUS) is angled inward relative to the heel.


SOD-1 Protein
Superoxide Dismutase-1
Cu-Zn Superoxide Dismutase
Cuprozinc Superoxide Dismutase
Superoxide Dismutase 1
SOD1 Protein

A superoxide dismutase (SOD1) that requires copper and zinc ions for its activity to destroy SUPEROXIDE FREE RADICALS within the CYTOPLASM. Mutations in the SOD1 gene are associated with AMYOTROPHIC LATERAL SCLEROSIS-1.


Transfer RNA, Amino Acid-Specific
Amino Acid-Specific Transfer RNA
RNA, Transfer, Amino Acid-Specific
tRNA (Amino Acid)
tRNA-Amino Acid
Amino Acid-Specific tRNA
RNA, Transfer, Amino Acid Specific

A group of transfer RNAs which are specific for carrying each one of the 20 amino acids to the ribosome in preparation for protein synthesis.


Artificial Insemination
Eutelegenesis
Insemination, Artificial

Artificial introduction of SEMEN or SPERMATOZOA into the VAGINA to facilitate FERTILIZATION.


Peptidylprolyl Isomerase
PPIase
Proline Rotamase
Proline Isomerase
Prolyl Isomerase
Peptidyl-Prolyl cis-trans-Isomerase

An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.


Lip Piercing
Tongue Piercing
Navel Piercing
Eyebrow Piercing
Piercing, Body
Body Piercing
Nipple Piercing
Ear Piercing

The perforation of an anatomical region for the wearing of jewelry.


Mupirocin, Calcium Salt (2:1), Dihydrate

A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.


Heat Exhaustion
Heat Prostration
Heat Collapse

A clinical syndrome caused by heat stress, such as over-exertion in a hot environment or excessive exposure to sun. It is characterized by SWEATING, water (volume) depletion, salt depletion, cool clammy skin, NAUSEA, and HEADACHE.


Suppressors of Cytokine Signaling Proteins

Suppressor of Cytokine Signaling Proteins

A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.


A mobile U-shaped bone that lies in the anterior part of the neck at the level of the third CERVICAL VERTEBRAE. The hyoid bone is suspended from the processes of the TEMPORAL BONES by ligaments, and is firmly bound to the THYROID CARTILAGE by muscles.


Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.


Necrotic DNA Degradation
DNA Degradation, Necrotic

The random catabolism of DNA accompanying the irreversible damage to tissue which leads to the pathological death of one or more cells.


Glomerular Procoagulant Activity
Blood Coagulation Factor III
Prothrombinase
Tissue Factor Procoagulant
Coagulin
Factor III
Thromboplastin
Tissue Thromboplastin
Antigens, CD142
Tissue Factor
CD142 Antigens
Coagulation Factor III
Urothromboplastin

Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.


A species of the family Ranidae (true frogs). The only anuran properly referred to by the common name "bullfrog", it is the largest native anuran in North America.


Powdered exudate from various Acacia species, especially A. senegal (Leguminosae). It forms mucilage or syrup in water. Gum arabic is used as a suspending agent, excipient, and emulsifier in foods and pharmaceuticals.


Peroxisome Proliferator-Activated Receptor alpha

A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.


Sweat Gland Neoplasms
Neoplasms, Sweat Gland

New abnormal growth of tissue in the SWEAT GLANDS.


Tamm-Horsfall Glycoprotein
Uromucoid
Tamm-Horsfall Protein
Uromodulin

A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. The cleaved form of the protein is found abundantly in URINE.


Ribonucleoprotein, U2 Small Nuclear
Small Nuclear Ribonucleoproteins, U2
U2 snRNP
U2 Small Nuclear Ribonucleoproteins
Ribonucleoproteins, Small, U2

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.


Primrose, Evening
Evening Primrose
Oenothera biennis

A plant species, of the genus OENOTHERA, family ONAGRACEAE, that is the source of evening primrose oil.


A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.


Programmed Cell Death 1 Receptor
Antigens, CD279
PD-1 Receptor
CD279 Antigen
PD1 Receptor
Programmed Cell Death 1 Protein

An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.


Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda

A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.


Laryngopharynges Hypopharynges Laryngopharynxes Hypopharynxes Hypopharynx Laryngopharynx

The bottom portion of the pharynx situated below the OROPHARYNX and posterior to the LARYNX. The hypopharynx communicates with the larynx through the laryngeal inlet, and is also called laryngopharynx.


Heparin-Binding Fibroblast Growth Factor Class I

A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).


A compound that, along with its isomer, Cleland's reagent (DITHIOTHREITOL), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups.


A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. They were originally isolated from CHOLINERGIC FIBERS of TORPEDO.


Vesicle Neurotransmitter Transporter Proteins

Vesicular Neurotransmitter Transporter Proteins

Neurotransmitter Transport Proteins, Vesicular

Vesicular Neurotransmitter Transport Proteins

A family of neurotransmitter transporter proteins that are INTEGRAL MEMBRANE PROTEINS of the LIPID BILAYER of SECRETORY VESICLES. They are ANTIPORTERS that exchange vesicular PROTONS for cytoplasmic NEUROTRANSMITTER and play an essential role in regulating neurotransmission.


Sterol-Regulatory Element-Binding Protein 2

Sterol Regulatory Element Binding Protein 2

A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.


Syndrome of Inappropriate ADH (SIADH) Secretion

Antidiuretic Hormone, Inappropriate Secretion

Inappropriate Vasopressin Secretion Syndrome

A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.


Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.


Deliberate Self-Harm
Non-Suicidal Self Injury
Self-Injurious Behavior
Nonsuicidal Self Injury
Self-Destructive Behavior
Self-Injury

Behavior in which persons hurt or harm themselves without the motive of suicide or of sexual deviation.


Crystallins, beta A Chain
beta A-Crystallin
beta-Crystallin, A Subunit
beta-Crystallin A Chain


Avian Paramyxovirus 1
Newcastle disease virus
Paramyxovirus 1, Avian

The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.


Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant

An autosomal dominant form of ectodermal dysplasia which is due to mutations in the gene for the EDAR RECEPTOR.


Bradykinin B1 Receptor Inhibitors
Bradykinin B1 Receptor Blockers
Bradykinin B1 Receptor Antagonists
Bradykinin B1 Antagonists

Compounds and drugs that inhibit ligand binding or cellular signaling by BRADYKININ B1 RECEPTORS.


Bacterial Infections, Gram-Negative
Gram-Negative Bacterial Infections
Infections, Gram-Negative Bacterial

Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.


NSC-32946
MGBG
Methyl-gag
Methylglyoxal Bis(guanylhydrazone)
Mitoguazone

Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.


Restriction Fragment Length Polymorphisms

Polymorphism, Restriction Fragment Length

Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.


IL5 Receptor
Interleukin 5 Receptor
Interleukin-5 Receptor
IL-5 Receptors
Interleukin-5 Receptors
Receptors, Interleukin-5

Cell surface receptors that are specific for INTERLEUKIN-5. They are heterodimeric proteins consisting of the INTERLEUKIN-5 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR COMMON BETA SUBUNIT. Signaling from interleukin-5 receptors can occur through interaction of their cytoplasmic domains with SYNTENINS.


Interferon Type I
Type I Interferon
Type I Interferons
Interferons Type I

Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).


Insulin-Like Growth Factor Binding Protein 3

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.


The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.


Nerve Growth Factor-Inducible Large External Glycoprotein

A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.


A urine test for formiminoglutamic acid, an intermediate metabolite in L-histidine catabolism in the conversion of L-histidine to L-glutamic acid. It may be an indicator of vitamin B12 or folic acid deficiency or liver disease.


Nitric Oxide
Nitrogen Monoxide
Endogenous Nitrate Vasodilator
Mononitrogen Monoxide
Nitric Oxide, Endothelium-Derived

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.


LeFort Osteotomy
Osteotomy, Le Fort
Osteotomy, LeFort

Transverse sectioning and repositioning of the maxilla. There are three types: Le Fort I osteotomy for maxillary advancement or the treatment of maxillary fractures; Le Fort II osteotomy for the treatment of maxillary fractures; Le Fort III osteotomy for the treatment of maxillary fractures with fracture of one or more facial bones. Le Fort III is often used also to correct craniofacial dysostosis and related facial abnormalities. (From Dorland, 28th ed, p1203 & p662)


Gram-Negative Bacteria
Gram Negative Bacteria

Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.


Coronary Artery Stenosis
Coronary Stenoses
Coronary Stenosis

Narrowing or constriction of a coronary artery.


Receptor, EphB4
EphB4 Receptor
EPHB4 Protein
Hepatoma Transmembrane Kinase

An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of proteins in this class there is little or no expression of EphB4 receptor in the BRAIN. It has been found at high levels in developing mammary glands and in invasive mammary tumors.


Choline Phosphokinase
Choline Kinase
ATP Choline Transphosphatase

An enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of ATP. Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. EC 2.7.1.32.


Epithelial Attachment
Junctional Epithelium
Epithelium, Junctional

A wedge-shaped collar of epithelial cells which form the attachment of the gingiva to the tooth surface at the base of the gingival crevice.


Surface-Active Agents
Surface Active Agents
Surfactants
Tensides
Amphiphilic Agents

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.


Fuchsins
Magentas
Triphenylmethane Aniline Compounds
Fuchsin
Rosaniline Dyes

Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.


Eighth Cranial Nerve Injury
Vestibulocochlear Nerve Avulsion
Eighth-Nerve Trauma
Eighth Cranial Nerve Injuries
Injury, Cranial Nerve VIII
Eighth-Nerve Palsy, Traumatic
Cranial Nerve VIII Injury
Vestibulocochlear Neuropathy, Traumatic
Traumatic Eighth-Nerve Palsy
Vestibulocochlear Nerve Trauma
Injury, Eighth Cranial Nerve
Vestibulocochlear Nerve Contusion
Vestibulocochlear Nerve Transection
Vestibulocochlear Nerve Injuries

Traumatic injuries to the VESTIBULOCOCHLEAR NERVE.


A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.


Influenza A Virus, H1N2 Subtype
H1N2 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 1 and neuraminidase 2. It is endemic in both human and pig populations.


Electrochromatography, Capillary
Capillary Electrochromatography
Chip Electrochromatography

A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS.


The study of literature written in languages of Asia and the Far East, including grammar, etymology, criticism, literary history, and language and linguistic history.


Cyclic GMP-Dependent Protein Kinase Type II

A cyclic GMP-dependent protein kinase subtype that is expressed predominantly in INTESTINES, BRAIN, and KIDNEY. The protein is myristoylated on its N-terminus which may play a role its membrane localization.


A family of proteins that promote unwinding of RNA during splicing and translation.


Infection with parasitic protozoa of the genus ISOSPORA, producing intestinal disease. It is caused by ingestion of oocysts and can produce tissue cysts.


Film, Radiographic
Film, X-Ray
Xray Film
X-Ray Film
Radiographic Film

A film base coated with an emulsion designed for use with x-rays.


Cryofixation
Cryopreservation
Cryonic Suspension

Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.


Adonis
Adonis vernalis
Oxeye Daisy
Daisy, Oxeye

A plant genus of the family RANUNCULACEAE. Members contain cardenolide oligoglycosides such as adoniside, adonisidum and alepposide.


Mammalian Type C Retroviruses
Tumor Viruses, Murine
Viper retrovirus
Type C Retroviruses, Mammalian
Retroviruses Type C, Mammalian
Gammaretrovirus

A species of GAMMARETROVIRUS isolated from vipers.


Eye Infections, Viral
Viral Eye Infections
Ocular Infections, Viral

Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.


Chromosome 20
Chromosomes, Human, Pair 20

A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.


Resistance, Antineoplastic Agent
Resistance, Antineoplastic Drug
Antineoplastic Agent Resistance
Antibiotic Resistance, Neoplasm
Drug Resistance, Neoplasm
Neoplasm Drug Resistance
Drug Resistance, Antineoplastic
Antineoplastic Drug Resistance

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.


Colon Cancer, Nonpolyposis Type 2 Protein

Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.


Cyclacillin Ciclacillin Aminocyclohexylpenicillin Wy-4508

A cyclohexylamido analog of PENICILLANIC ACID.


Cytochrome P-450 CYP1A2 Inhibitors
CYP1A2 Inhibitors
P450 CYP1A2 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2.


Pathological or accidental introduction of air into the retroperitoneal space.


The weight of the FETUS in utero. It is usually estimated by various formulas based on measurements made during PRENATAL ULTRASONOGRAPHY.


Deficiency, Riboflavin
Riboflavin Deficiency

A dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (Dorland, 27th ed)


Receptors, Tumor Necrosis Factor, Type I

TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A)

Receptors, Tumor Necrosis Factor, Member 1A

A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.


Phosphatidylinositol Kinase Type II
PI 4-Kinase
Phosphatidylinositol 4-Kinase
PtdIns 4-Kinase
Phosphoinositide Kinase
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositiol Kinase

An enzyme that catalyzes the conversion of phosphatidylinositol (PHOSPHATIDYLINOSITOLS) to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.


Agency for Healthcare Research and Quality (U.S.)

United States Agency for Healthcare Research and Quality

An agency of the PUBLIC HEALTH SERVICE established in 1990 to "provide indexing, abstracting, translating, publishing, and other services leading to a more effective and timely dissemination of information on research, demonstration projects, and evaluations with respect to health care to public and private entities and individuals engaged in the improvement of health care delivery..." It supersedes the National Center for Health Services Research. The United States Agency for Health Care Policy and Research was renamed Agency for Healthcare Research and Quality (AHRQ) under the Healthcare Research and Quality Act of 1999.


Observational Study as Topic
Observational Studies as Topic

Works about clinical studies in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).


Purinergic Receptor P2Y, G-Protein Coupled, 1

A subclass of purinergic P2Y receptors that have a preference for ATP and ADP. The activated P2Y1 receptor signals through the G-PROTEIN-coupled activation of PHOSPHOLIPASE C and mobilization of intracellular CALCIUM.


Psychogenetics
Genetics, Behavioral
Behavioral Genetics

The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.


Nucleotide Oligomerization Domain 2 Protein

A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.


Hormone
Hormones
Hormone Receptor Agonists

Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.


A class in the phylum MOLLUSCA comprised of SNAILS and slugs. The former have coiled external shells and the latter usually lack shells.


Oncogene Proteins, Fusion
Oncogene Proteins, Chimeric
Fusion Proteins, Oncogene
Oncogene Fusion Proteins
Chimeric Proteins, Oncogene
Chimeric Oncogene Proteins

The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.


The two dissimilar sized ribonucleoprotein complexes that comprise a RIBOSOME - the large ribosomal subunit and the small ribosomal subunit. The eukaryotic 80S ribosome is composed of a 60S large subunit and a 40S small subunit. The bacterial 70S ribosome is composed of a 50S large subunit and a 30S small subunit.


Growth Plate Injuries
Salter-Harris Fractures
Growth Plate Fractures


Cycloaddition
Diels-Alder Reaction
Cycloaddition Reaction Techniques
Cycloaddition Reaction

Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.


Cholestanols
Hydroxycholestanes
Bile Alcohols

Cholestanes substituted in any position with one or more hydroxy groups. They are found in feces and bile. In contrast to bile acids and salts, they are not reabsorbed.


Reproductive Medicine
Medicine, Reproductive

A medical-surgical specialty concerned with the morphology, physiology, biochemistry, and pathology of reproduction in man and other animals, and on the biological, medical, and veterinary problems of fertility and lactation. It includes ovulation induction, diagnosis of infertility and recurrent pregnancy loss, and assisted reproductive technologies such as embryo transfer, in vitro fertilization, and intrafallopian transfer of zygotes. (From Infertility and Reproductive Medicine Clinics of North America, Foreword 1990; Journal of Reproduction and Fertility, Notice to Contributors, Jan 1979)


Fetal Transfusion
Blood Transfusion, Intrauterine
Intrauterine Transfusion

In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).


An RNA-binding protein characterized by three RNA RECOGNITION MOTIFS. It binds to AU RICH ELEMENTS in the 3'-untranslated regions of mRNA and regulates alternative pre-RNA splicing and mRNA translation; it may also function in APOPTOSIS. Mutations in the TIA-1 gene are associated with WELANDER DISTAL MYOPATHY.


The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.


Leishmania (Leishmania) tropica
Leishmania leishmania tropica
Leishmania tropica
Leishmania tropica minor

A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and rodents. This taxonomic complex includes species which cause a disease called Oriental sore which is a form of cutaneous leishmaniasis (LEISHMANIASIS, CUTANEOUS) of the Old World.


Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.


A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.


Nanogels
Nanocomposite Hydrogels
Nanocomposite Gels

Three-dimensional biocompatible materials formed by cross-linking a hydrophilic polymeric component (e.g., HYDROGELS). They are typically spherical particles in a size range of 20-250 nm when used for drug delivery applications.


Auditory Fatigue
Temporary Threshold Shift, Auditory
Fatigue, Auditory

Loss of sensitivity to sounds as a result of auditory stimulation, manifesting as a temporary shift in auditory threshold. The temporary threshold shift, TTS, is expressed in decibels.


United States. Dept. of Veterans Affairs

United States Department of Veterans Affairs

A cabinet department in the Executive Branch of the United States Government concerned with overall planning, promoting, and administering programs pertaining to VETERANS. It was established March 15, 1989 as a Cabinet-level position.


Guthymine Guthimine Gutimine Gutimin Guanylthiourea

May protect against hypoxic damage; proposed for treatment of shock due to trauma or blood loss; also stimulates paretic gastrointestinal system.


A naturally occurring metabolite of HISTIDINE that has antioxidant properties.


A group of ethane-based halogenated hydrocarbons containing one or more fluorine and chlorine atoms.


Receptor-Like Protein Tyrosine Phosphatases, Class 6

Receptor-Like Protein Tyrosine Phosphatases, Class 1,6

Receptor-Like Protein Tyrosine Phosphatases, Class I

A subclass of receptor-like protein tryosine phosphatases that contain heavily glycosylated and cysteine-rich extracellular regions that include fibronectin type III-like domains.


Halogenated Hydrocarbons
Hydrocarbons, Halogenated

Hydrocarbon compounds with one or more HYDROGEN atoms substituted with HALOGENS.


A thioxanthine with effects similar to the phenothiazine antipsychotics.


Transformation, Bacterial
Bacterial Transformation

The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.


Persons living in the United States having origins in any of the black groups of Africa.


A class of enzymes that catalyzes the degradation of gelatin by acting on the peptide bonds. EC 3.4.24.-.


Vulvar Vestibulitis Syndrome
Vulvar Vestibulitis

Inflammation of the vulvar vestibular region at the entrance of the VAGINA, generally involving surface mucosa and submucosal vestibular glands. It is characterized by ERYTHEMA and chronic recurrent pain in this area.


Homeobox Transcription Factor Csx-Nkx2-5

A homeobox-containing transcription factor that functions in heart development. Mutations in the NKX2-5 gene are associated with ATRIAL SEPTAL DEFECTS and TETRALOGY OF FALLOT.


Pancreatic Hormone Receptors
Pancreatic Hormone Receptor
Receptors, Pancreatic Hormone
Receptors, Pancreatic Hormones

Cell surface proteins that bind pancreatic hormones with high affinity and trigger intracellular changes which influence the behavior of cells. These include receptors for glucagon (secreted by alpha cells), insulin (secreted by beta cells), somatostatin (secreted by delta cells), and pancreatic peptide (secreted by PP cells). Some of these hormones and receptors also support neurotransmission.


Deficiency, Factor Seven
Deficiency, Factor 7
Factor 7 Deficiency
Hypoproconvertinemia
Deficiency, Factor VII
Factor VII Deficiency

An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.


Spanish Flu Pandemic, 1918-1919
Influenza Pandemic, 1918-1919
H1N1 Influenza Pandemic, 1918-1919

The influenza outbreaks of 1918 to 1919 also known as Spanish flu pandemic. First reported in Haskell County in Kansas in March of 1918 the disease spread throughout the world and may have killed as many as 25 million people.


Cytochrome P450 Family 46
CYP46 Family
CYP46
CYP46 Enzymes
Cytochrome P-450 CYP46

A cytochrome P450 enzyme family that includes CHOLESTEROL 24-HYDROXYLASE, which is expressed primarily in the brain and functions in CHOLESTEROL metabolism.


Medical Illustration
Illustration, Medical

The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.


Infectious Disease Reporting
Notification, Disease
Disease Notification
Exposure Notification

Notification or reporting by a physician or other health care provider of the occurrence of specified contagious diseases such as tuberculosis and HIV infections to designated public health agencies. The United States system of reporting notifiable diseases evolved from the Quarantine Act of 1878, which authorized the US Public Health Service to collect morbidity data on cholera, smallpox, and yellow fever; each state in the US has its own list of notifiable diseases and depends largely on reporting by the individual health care provider. (From Segen, Dictionary of Modern Medicine, 1992)


Hepatic Venous Outflow Obstruction
Budd-Chiari Syndrome
Chiari's Syndrome
Hepatic Vein Thrombosis

A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon.


Sea Level Rise
Sea-Level Rise
Rising Sea Level

An increase in the volume of the oceans and seas causing an elevation of the air-sea interface.


Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).


2-Phenethylhydrazine
Nardil
Phenelzine Sulfate
Nardelzine
beta-Phenylethylhydrazine
Fenelzin
Phenethylhydrazine
Phenelzine

One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.


Exposure, Environmental
Environmental Exposure

The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.


Infections, Herpesviridae
Infections, Herpesvirus
Herpesviridae Infections
Herpesvirus Infections
B Virus Infection

Virus diseases caused by the HERPESVIRIDAE.


Ewing Sarcoma Breakpoint Region 1 Protein

Ewing Sarcoma Breakpointregion 1 Protein

A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.


Receptors, Tumor Necrosis Factor, Member 10c

Tumor Necrosis Factor Receptor Superfamily, Member 10c

A secreted tumor necrosis factor receptor family member that has specificity for TNF-RELATED APOPTOSIS-INDUCING LIGAND. It plays a modulating role in activation of APOPTOSIS signaling.


Diseases that occur in VERTEBRATE animals.


Lingua Plicata
Scrotal Tongue
Tongue, Fissured
Tongue, Furrowed

The occurrence of of breaks or slits in the tissue of the dorsal surface of the TONGUE.


Receptors, Somatotropin Release Inhibiting Hormone

Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.


Service, Cardiology Hospital
Hospital Cardiology Service
Cardiology Service, Hospital
Service, Hospital Cardiology

The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cardiac patient.


Papular Mucinosis
Lichen Myxedematosus
Scleromyxedema

A connective tissue disorder characterized by widespread thickening of SKIN with a cobblestone-like appearance. It is caused by proliferation of FIBROBLASTS and deposition of MUCIN in the DERMIS in the absence of thyroid disease. Most scleromyxedema cases are associated with a MONOCLONAL GAMMOPATHY, immunoglobulin IgG-lambda.


Insurance providing coverage for physical injury suffered as a result of unavoidable circumstances.


A type II keratin found predominantly expressed in the terminally differentiated EPIDERMIS of palms and soles. Mutations in the gene for keratin 9 are associated with KERATODERMA, PALMOPLANTAR, EPIDERMOLYTIC.


Hematinics
Hematopoietic Agents
Erythropoiesis Stimulating Agents

Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.


Nucleoside Q*
Q-Ribonucleoside
Nucleoside Q
Queuosine
Q Nucleoside

A modified nucleoside which is present in the first position of the anticodon of tRNA-tyrosine, tRNA-histidine, tRNA-asparagine and tRNA-aspartic acid of many organisms. It is believed to play a role in the regulatory function of tRNA. Nucleoside Q can be further modified to nucleoside Q*, which has a mannose or galactose moiety linked to position 4 of its cyclopentenediol moiety.


Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology.


Guided Tissue Regeneration
Regeneration, Guided Tissue

Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.


Methylglucamine Iothalamate
Meglumine Iothalamate
Methylglucamine Iotalamate
Conray 60
Iotalamate Meglumine
Iothalamic Acid Meglumine
Meglumine Iotalamate
Iothalamic Acid Methylglucamine
Iothalamate Meglumine

A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.


Digital Scanned Projection Radiography, Dual Energy

Radiography, Dual Energy Scanned Projection

Dual Energy Scanned Projection Radiography

Digital Scan Projection Radiography, Dual Energy

Radiography, Dual-Energy Scanned Projection

Digital Scanned Projection Radiography, Dual-Energy

Dual-Energy Scanned Projection Radiography

Digital Scan Projection Radiography, Dual-Energy

A method of producing a high-quality scan by digitizing and subtracting the images produced by high- and low-energy x-rays.


Post-traumatic Growth, Psychological
Posttraumatic Growth
Posttraumatic Growth, Psychological

Positive change experienced as a result of the struggle with a major life crisis or a traumatic event.


Chondrodysplasia Punctata, Rhizomelic Form

An autosomal recessive form of CHONDRODYSPLASIA PUNCTATA characterized by defective plasmalogen biosynthesis and impaired peroxisomes. Patients have shortened proximal limbs and severely disturbed endochondral bone formation. The metabolic defects associated with the impaired peroxisomes are present only in the rhizomelic form of chondrodysplasia punctata. (From Scriver et al, Metabolic Basis of Inherited Disease, 6th ed, p1497)


T-Lymphotropic Virus 1, Primate
Primate T-lymphotropic virus 1
PTLV-1

A species in the family DELTARETROVIRUS comprising strains of different host species but arising from the same geographic origin. They include HUMAN T-LYMPHOTROPIC VIRUS 1 and SIMIAN T-LYMPHOTROPIC VIRUS 1.


Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.


Independent Medical Assessment
Independent Medical Evaluation
Independent Medical Examination
Independent Medical Examinations

An assessment of HEALTH STATUS requested by third parties (e.g. insurers, adjudicating bodies, law enforcement, attorneys, etc) on a subject’s functional ability. Such information may be used in optimizing treatment or making informed decisions on compensation.


Glucuronates
Glucuronic Acids
Glucosiduronates

Derivatives of GLUCURONIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the 6-carboxy glucose structure.


Mammary-Derived Growth Inhibitor Related Protein

A fatty acid-binding protein expressed by ASTROCYTES during CENTRAL NERVOUS SYSTEM development, and by MALIGNANT GLIOMA cells. It is also expressed by ASTROCYTES in response to injury or ISCHEMIA, and may function in repair of the MYELIN SHEATH.


Methaqualone Hydrochloride
Quaalude
Ortonal
Metolquizolone
Methaqualone
Optimil

A quinazoline derivative with hypnotic and sedative properties. It has been withdrawn from the market in many countries because of problems with abuse. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)


Fluorometric Analysis
Fluorimetry
Fluorometry

An analytical method for detecting and measuring FLUORESCENCE in compounds or targets such as cells, proteins, or nucleotides, or targets previously labeled with FLUORESCENCE AGENTS.


The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.


The systematic search and discovery of natural substances which may have potential commercial applications.


GLP-2 Receptor
GLP2R Protein
GLP-2R Receptor
Glucagon-Like Peptide 2 Receptor
Glucagon-Like Peptide-2 Receptor

A receptor for GLUCAGON-LIKE PEPTIDE 2 (GLP-2) that is expressed on the surface of intestinal cells as well as neural cells. GLP-2 and other peptides act through GLP-2R to regulate cellular responses to BLOOD GLUCOSE, INFLAMMATION, and FOOD INTAKE.


Ribonucleic acid in algae having regulatory and catalytic roles as well as involvement in protein synthesis.


Recession, Economic
Economic Depression
Economic Recession

Severe economic downturn that lasts several years.


Delivery, Vacuum Extraction
Vacuum Extraction, Obstetric
Vacuum Extraction, Obstetrical

Removal of the fetus from the uterus or vagina at or near the end of pregnancy with a metal traction cup that is attached to the fetus' head. Negative pressure is applied and traction is made on a chain passed through the suction tube. (From Stedman, 26th ed & Dorland, 28th ed)


Scanning Transmission Electron Microscopy

Electron Microscopy, Scanning Transmission

Microscopy, Electron, Scanning Transmission

A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.


Hookah Tobacco
Dokha
Tobacco, Waterpipe
Waterpipe Tobacco
Tobacco, Water Pipe

Flavored tobacco whose vapor or smoke is passed through a water basin before inhalation.


Itai-Itai
Cadmium Poisoning
Poisoning, Cadmium

Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.


Glucose Dependent Insulinotropic Peptide

A gastrointestinal peptide hormone of about 43-amino acids. It is found to be a potent stimulator of INSULIN secretion and a relatively poor inhibitor of GASTRIC ACID secretion.


Public Health Education for Professionals

Education and training in PUBLIC HEALTH for the practice of the profession.


Edrophonium Bromide
Tensilon
Edrophonium Chloride
Edrophonium
Edroponium

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.


Receptors, Histamine
Histamine Receptors
Histamine Receptor
Histamine Binding Sites

Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.


RNA Polymerase II Transcription Factor D

The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.


Difference Limen
Differential Threshold
Weber-Fechner Law
Just-Noticeable Difference

The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.


An enzyme that transfers acyl groups from acyl-CoA to glycerol-3-phosphate to form monoglyceride phosphates. It acts only with CoA derivatives of fatty acids of chain length above C-10. Also forms diglyceride phosphates. EC 2.3.1.15.


Dominance, Cerebral
Hemispheric Specialization
Cerebral Dominance

Dominance of one cerebral hemisphere over the other in cerebral functions.


The period of OBSTETRIC LABOR that is from the complete dilatation of the CERVIX UTERI to the expulsion of the FETUS.


Uterine Cervical Erosion
Uterine Cervix Erosion
Cervix Erosion

Loss or destruction of the epithelial lining of the UTERINE CERVIX.


Metamfetamine
Madrine
Methamphetamine
Deoxyephedrine
Desoxyephedrine
Methamphetamine Hydrochloride
N-Methylamphetamine
Methylamphetamine
Desoxyn

A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.


Spergon Tetrachloro-1,4-benzoquinone Coversan 2,3,5,6-Tetrachloro-1,4-benzoquinone Chloranil Reranil Vulklor

A quinone fungicide used for treatment of seeds and foliage.


Nursing Education, Postgraduate
Postgraduate Nursing Education
Education, Nursing, Graduate
Graduate Nursing Education
Nursing Education, Graduate
Education, Nursing, Postgraduate

Those educational activities engaged in by holders of a bachelor's degree in nursing, which are primarily designed to prepare them for entrance into a specific field of nursing, and may lead to board certification or a more advanced degree.


Infection with nematodes of the genus DIROFILARIA, usually in animals, especially dogs, but occasionally in man.


Purine Hydroxylase I
Xanthine Oxidoreductase
Xanthine Dehydrogenase

An enzyme that catalyzes the oxidation of XANTHINE in the presence of NAD+ to form URIC ACID and NADH. It acts also on a variety of other purines and aldehydes.


Meclofenoxate Hydrochloride
Atsefen
Cerutil
Centrophenoxine
Meclofenoxate
Cetrexin
Helfergin

An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.


Immunologic adjuvant and sensitizing agent.


Base of Skull
Basicranium
Cranial Base
Basis cranii
Skull Base

The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface.


A species of tick (TICKS) in the family IXODIDAE, distributed throughout the world but abundant in southern Europe. It will feed on a wide variety of MAMMALS, but DOGS are its preferred host. It transmits a large number of diseases including BABESIOSIS; THEILERIASIS; EHRLICHIOSIS; and MEDITERRANEAN SPOTTED FEVER.


A plant genus of the family MYRSINACEAE. Members contain ardisiacrispins (oleanane triterpenoid saponins), ardicrenin, and cyclamiretin.


Osteopathic Manipulative Treatment
Manipulation, Osteopathic
Osteopathic Manipulation

Musculoskeletal manipulation based on the principles of OSTEOPATHIC MEDICINE developed in 1874 by Dr Andrew Taylor Still.


Information Systems, Clinical Laboratory

Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.


Calcitonin Receptor-Like Protein
Calcitonin Receptor-Like Receptor

A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.


Neurofibromin 1
NF-1 Protein
Neurofibromin
Neurofibromatosis Type 1 Gene Product
NF1 GRP
NF1 Protein
Neurofibromatosis Type 1 Protein
NF1-GAP-Related Protein

A protein found most abundantly in the nervous system. Defects or deficiencies in this protein are associated with NEUROFIBROMATOSIS 1, Watson syndrome, and LEOPARD syndrome. Mutations in the gene (GENE, NEUROFIBROMATOSIS 1) affect two known functions: regulation of ras-GTPase and tumor suppression.


Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.


A carpal bone which is located between the TRAPEZIUM BONE and the CAPITATE BONE.


Postpartum Thyroiditis
Post-partum Thyroiditis

Transient autoimmune thyroiditis occurring in the POSTPARTUM PERIOD. It is characterized by the presence of high titers of AUTOANTIBODIES against THYROID PEROXIDASE and THYROGLOBULIN. Clinical signs include the triphasic thyroid hormone pattern: beginning with THYROTOXICOSIS, followed with HYPOTHYROIDISM, then return to euthyroid state by 1 year postpartum.


Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).


High-Mobility Group (Nonhistone Chromosomal) Protein 2

A 23-kDa HMG-box protein that binds to and distorts the minor grove of DNA.


Abducens Nerve Injury
Injury, Sixth Cranial Nerve
Sixth-Nerve Trauma
Abducens Neuropathy, Traumatic
Sixth Cranial Nerve Injuries
Cranial Nerve VI Injury
Traumatic Sixth-Nerve Palsy
Abducens Nerve Trauma
Injury, Cranial Nerve VI
Sixth-Nerve Palsy, Traumatic
Sixth Cranial Nerve Injury

Traumatic injury to the abducens, or sixth, cranial nerve. Injury to this nerve results in lateral rectus muscle weakness or paralysis. The nerve may be damaged by closed or penetrating CRANIOCEREBRAL TRAUMA or by facial trauma involving the orbit.


Deoxyribonucleases, Type II, Site Specific

Deoxyribonucleases, Type II, Site-Specific

Type II Site-Specific Deoxyribonucleases

Deoxyribonucleases, Type II Site-Specific

Type II Site Specific Deoxyribonucleases

Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.


A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".


Movement Protein, Plant Virus
Plant Virus Movement Proteins
Viral Movement Proteins, Plant
Virus Movement Proteins, Plant
Movement Proteins, Plant Virus
Movement Proteins, Virus, Plant
Movement Proteins, Viral, Plant
Plant Viral Movement Proteins

Viral proteins that facilitate the movement of viruses between plant cells by means of PLASMODESMATA, channels that traverse the plant cell walls.


Keratitis, Herpetic
Herpes Simplex, Ocular
Ocular Herpes Simplex
Herpes Simplex Keratitis

A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)


Receptors, Dopamine D3
Dopamine D3 Receptor
Dopamine D3 Receptors
Receptor, Dopamine-D3
Dopamine Receptor D3

A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.


A refractive error in which rays of light entering the eye parallel to the optic axis are brought to a focus behind the retina, as a result of the eyeball being too short from front to back. It is also called farsightedness because the near point is more distant than it is in emmetropia with an equal amplitude of accommodation. (Dorland, 27th ed)


Spherical particles of nanometer dimensions.


Purinergic Receptor P2X, Ligand-Gated Ion Channel, 1

A purinergic P2X neurotransmitter receptor found at sympathetically innervated SMOOTH MUSCLE. It may play a functional role regulating the juxtoglomerular apparatus of the KIDNEY.


Sheets of latex rubber punched and placed over the teeth during dental procedures to isolate the field of operation from the rest of the oral cavity (Jablonski; Illustrated Dictionary of Dentistry, 1982). Rubber dams are useful in preventing the swallowing of instruments or restorations during dental work.


2,6-Diaminopimelic Acid
Diaminopimelic Acid

A diamino derivative of heptanedioic acid with amino groups at C-2 and C-6 and the general formula (COOH)CH(NH2)CH2CH2CH2CH(NH2)(COOH).


Acetyl-CoA Hydrolase
Acetyl Coenzyme A Hydrolase
Acetyl-CoA Acylase
Acetyl-CoA Deacylase

An enzyme that catalyzes reversibly the hydrolysis of acetyl-CoA to yield CoA and acetate. The enzyme is involved in the oxidation of fatty acids. EC 3.1.2.1.


Fused Heterocyclic Compounds, Two-Ring
Two Ring Heterocyclic Compounds
Heterocyclic Compounds, 2-Ring

A class of heterocyclic compounds that include a two-ring fused structure. Both aromatic and non-aromatic ring structures are included in this category.


bcl2 Homologous Antagonist-Killer Protein

bcl-2 Homologous Antagonist-Killer Protein

An isoform of Bak protein containing only the N-terminal BH3 domain. N-Bak promotes neuronal apoptosis.


Urine Collection
Urine Specimen Collection

Methods or procedures used to obtain samples of URINE.


Plasmids containing at least one cos (cohesive-end site) of PHAGE LAMBDA. They are used as cloning vehicles.


Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.


Third-Nerve Paralysis
Oculomotor Nerve Disorders
Cranial Nerve III Diseases
Third Cranial Nerve Diseases
Oculomotor Neuropathy
Oculomotor Nerve Paralysis
Total Third-Nerve Palsy
Oculomotor Nerve Palsy
Oculomotor Nerve Diseases
Third-Nerve Palsy
Partial Third-Nerve Palsy

Diseases of the oculomotor nerve or nucleus that result in weakness or paralysis of the superior rectus, inferior rectus, medial rectus, inferior oblique, or levator palpebrae muscles, or impaired parasympathetic innervation to the pupil. With a complete oculomotor palsy, the eyelid will be paralyzed, the eye will be in an abducted and inferior position, and the pupil will be markedly dilated. Commonly associated conditions include neoplasms, CRANIOCEREBRAL TRAUMA, ischemia (especially in association with DIABETES MELLITUS), and aneurysmal compression. (From Adams et al., Principles of Neurology, 6th ed, p270)


A plant genus of the family BRASSICACEAE. Some members contain CARDIAC GLYCOSIDES.


Cdc2-Related Protein Kinase
CDK2 Protein
p33cdk2 Kinase
Cyclin-Dependent Kinase 2
Cdk2 Protein Kinase

A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.


Taq DNA Polymerase
Thermus aquaticus Polymerase
Taq1 Polymerase
Taq Polymerase

A heat stable DNA-DIRECTED DNA POLYMERASE from the bacteria Thermus aquaticus. It is widely used for the amplification of genes through the process of POLYMERASE CHAIN REACTION. EC 2.7.7.-.


Olfactory Nerve Avulsion
Injury, Cranial Nerve I
First Cranial Nerve Injury
Cranial Nerve I Injury
Olfactory Neuropathy, Traumatic
Olfactory Nerve Trauma
Injury, First Cranial Nerve
Olfactory Nerve Injuries
Olfactory Nerve Injury
First-Nerve Trauma
Traumatic First-Nerve Palsy
First Cranial Nerve Injuries
Olfactory Nerve Contusion
First-Nerve Palsy, Traumatic
Olfactory Nerve Transection

Traumatic injuries to the OLFACTORY NERVE. It may result in various olfactory dysfunction including a complete loss of smell.


Glass Transition
Vitrification
Liquid-Glass Transition
Glass-Liquid Transition

The transformation of a liquid to a glassy solid i.e., without the formation of crystals during the cooling process.


A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.


Eotaxin-3
Chemokine CCL26
CCL26 Chemokine

A C-C chemokine expressed by all tissues that functions as a chemoattractant for EOSINOPHILS and BASOPHILS. It binds to the CCR3 RECEPTOR.


Protease-Activated Receptors
Proteinase-Activated Receptors
Endopeptidase-Activated Receptors
Receptors, Proteinase-Activated

A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain cryptic ligands that are exposed upon the selective proteolysis of specific N-terminal cleavage sites.


System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.


Practice Gaps
Professional Practice Gaps

Difference between observed and ideal DELIVERY OF HEALTH CARE and healthcare outcomes that reflect the current state of knowledge.


Female Condom
Condoms, Female
Female Condoms
Single-Use Internal Condom

A soft, loose-fitting polyurethane sheath, closed at one end, with flexible rings at both ends. The device is inserted into the vagina by compressing the inner ring and pushing it in. Properly positioned, the ring at the closed end covers the cervix, and the sheath lines the walls of the vagina. The outer ring remains outside the vagina, covering the labia. (Med Lett Drugs Ther 1993 Dec 24;35(12):123)


A plant genus of the family Orobanchaceae used in FOLK REMEDIES for the eyes.


Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.


env Proteins, Human Immunodeficiency Virus

env Gene Products, Human Immunodeficiency Virus

envelope Proteins, Human Immunodeficiency Virus

Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS.


Gram Negative Chemolithotrophic Bacteria

A large group of bacteria including those which oxidize ammonia or nitrite, metabolize sulfur and sulfur compounds, or deposit iron and/or manganese oxides.


Central Amygdala Nucleus
Central Nucleus of Amygdala
Central Amygdaloid Nucleus
Central Amygdala
Central Nucleus of the Amygdala

A nucleus located in the caudal half of the amygdala. It is a primary region involved in controlling responses and receives many intrinsic GABAergic amygdaloid connections.


Appetite-Stimulating Drugs
Appetite Stimulants

Agents that are used to stimulate appetite. These drugs are frequently used to treat anorexia associated with cancer and AIDS.


Low-Volume Hospitals
Hospitals, Low-Volume

Hospitals with a much lower than average utilization by physicians and smaller number of procedures.


Venous Cutdown
Cutdown, Venous
Vein Cutdown
Venostomy

Creation of a small incised opening in a vein to permit the passage of a needle or cannula for withdrawal of blood, administration of medication, or in diagnostic or therapeutic catheterization. (Dorland, 28th ed.; Stedman, 26th ed.)


Type-2 Helper T Cells
T Helper 2 Cells
T Helper2 Cells
TH-2 Cells
Th2 Cells

A subset of helper-inducer T-lymphocytes which synthesize and secrete the INTERLEUKINS IL-4; IL-5; IL-6; and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.


A plant genus of the family LAMIACEAE that contains phenylpropanoids.


A group of phenyl benzopyrans named for having structures like FLAVONES.


Cystathionine gamma-Lyase
Homoserine Deaminase
gamma-Cystathionase
Homoserine Dehydratase
Cystathionase
Cystine Desulfohydrolase
Cystine Desulfhydrase
Cysteine Desulfhydrase

A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.


Equipment that sends digital information over telephone lines. The term Modem is a short form of the phrase modulator-demodulator.


Medical Electronics
Electronics, Medical

The research and development of ELECTRICAL EQUIPMENT AND SUPPLIES for such medical applications as diagnosis, therapy, research, anesthesia control, cardiac control, and surgery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)


The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.


A cytochrome P-450 enzyme subtype that oxidizes several important groups of drugs including many PROTON PUMP INHIBITORS and ANTICONVULSANTS.


Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)


Comprehensive Health Care
Comprehensive Healthcare

Providing for the full range of personal health services for diagnosis, treatment, follow-up and rehabilitation of patients.


A plant genus of the family MYRTACEAE. The common name of tea tree more often refers to MELALEUCA or LEPTOSPERMUM.


Major egg yolk proteins from egg-laying animals such as non-mammalian VERTEBRATES; ARTHROPODS; and others. They are high-density lipoglycoproteins derived from circulating precursors, VITELLOGENINS. Vitellins serve as nutrients for the growing non-mammalian embryos (EMBRYO, NONMAMMALIAN).


Nervus Trigeminus
Fifth Cranial Nerve
Nerve V
Cranial Nerve V
Trigeminal Nerve

The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.


Fatty Tissue
Adipose Tissue
Fat Pad
Body Fat


The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur.


C-EBPalpha
CCAAT-Enhancer-Binding Protein-alpha
C-EBP alpha

A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.


A Rec A recombinase found in eukaryotes. Rad51 is involved in DNA REPAIR of double-strand breaks.


Oncogenes
Transforming Gene
Oncogene
Transforming Genes

Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.


A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.


Teucrium polium
Germander
Teucrium chamaedrys
Teucrium

A plant genus of the family Lamiaceae. Members contain teuscordonin. There have been reports of hepatotoxicity by this genus.


Cerebrospinal Fluid Shunt
Cerebrospinal Fluid Shunts
Shunt, Cerebrospinal Fluid
Shunts, Cerebrospinal Fluid

Tubes inserted to create communication between a cerebral ventricle and the internal jugular vein. Their emplacement permits draining of cerebrospinal fluid for relief of hydrocephalus or other condition leading to fluid accumulation in the ventricles.


Antigens, CD8
Leu-2 Antigens
T8 Antigens, T-Cell
CD8 Antigens
CD8 Antigen

Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. T8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.


Chemical compounds that induce menstruation either through direct action on the reproductive organs or through indirect action by relieving another condition of which amenorrhea is a secondary result. (From Dorland, 27th ed)


Receptors, Ionotropic Glutamate
Ionotropic Glutamate Receptors

A class of ligand-gated ion channel receptors that have specificity for GLUTAMATE. They are distinct from METABOTROPIC GLUTAMATE RECEPTORS which act through a G-protein-coupled mechanism.


Platelet-Derived Growth Factor Receptors

Receptors, Platelet-Derived Growth Factor

Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA) and the beta PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA) are the two principle types of PDGF receptors. Activation of the protein-tyrosine kinase activity of the receptors occurs by ligand-induced dimerization or heterodimerization of PDGF receptor types.


Biphasic Intermittent Positive Airway Pressure

Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.


Troxidone Trimetin Tridione Trimethadione

An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)


Dentistry for Aged
Dental Care for Aged
Dental Care for Elderly

The giving of attention to the special dental needs of the elderly for proper maintenance or treatment. The dental care may include the services provided by dental specialists.


Pinus taeda
Loblolly Pine
Pine, Loblolly

A plant species of the genus PINUS which is the subject of genetic study.


Medial Ulnar Collateral Ligament Reconstruction

Surgical reconstruction of injured or insufficient ULNAR COLLATERAL LIGAMENT in the ELBOW JOINT.


Factor XII
Coagulation Factor XII
Hageman Factor
Factor 12
Factor Twelve

Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.


A class of organic compounds composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n. The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES.


Xeroderma Pigmentosum Group A Complementing Protein

A ZINC FINGER MOTIF protein that recognizes and interacts with damaged DNA. It is a DNA-binding protein that plays an essential role in NUCLEOTIDE EXCISION REPAIR. Mutations in this protein are associated with the most severe form of XERODERMA PIGMENTOSUM.


p38 SAPK
p38 MAP Kinase
p38 MAPK
p38 Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase p38
p38 Protein Kinase

A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.


Water Conservation
Conservation of Water Resources
Water Resources Conservation

Preservation and or management of WATER RESOURCES especially under conditions of scarce supply.


Lung Capacity, Total
Total Lung Capacity

The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.


Hepatoblastoma G2 Cell Line
Cell Line, Hep G2
Cell Line, Hepatoblastoma G2
Hep G2 Cells
Hep G2 Cell Line
HepG2 Cells

A human liver tumor cell line used to study a variety of liver-specific metabolic functions.


A hair-containing cyst or sinus, occurring chiefly in the coccygeal region.


Arthroplasties, Replacement
Joint Replacement
Replacement Arthroplasties
Total Joint Replacement
Arthroplasty, Replacement
Joint Prosthesis Implantation
Replacement Arthroplasty

Partial or total replacement of a skeletal joint.


Subcutaneous Injections
Injections, Subcutaneous

Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.


Any observable response or action of a neonate or infant up through the age of 23 months.


The quality or state of being wettable or the degree to which something can be wet. This is also the ability of any solid surface to be wetted when in contact with a liquid whose surface tension is reduced so that the liquid spreads over the surface of the solid.


A philosophy of nursing practice that takes into account total patient care, considering the physical, emotional, social, economic, and spiritual needs of patients, their response to their illnesses, and the effect of illness on patients' abilities to meet self-care needs. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed, p745)


Island Flaps
Surgical Flaps
Flaps, Surgical
Surgical Flap
Pedicled Flap
Flap, Surgical

A mass of tissue that has been cut away from its surrounding areas for AUTOLOGOUS TRANSPLANTATION, except for its attachment via a strip of tissue containing the blood supply.


Type 1 Helper T Cells
Th1 Cells
TH-1 Cells
T Helper 1 Cells

A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.


Exercise Therapy
Therapy, Exercise
Remedial Exercise
Rehabilitation Exercise

A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.


Bleeding from the blood vessels of the mouth, which may occur as a result of injuries to the mouth, accidents in oral surgery, or diseases of the gums.


Sedentary Behavior
Physical Inactivity
Sedentary Lifestyle

Less than 150 minutes of moderate to vigorous intensity physical activity per week or 75 minutes of vigorous intensity physical activity per week.


An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.


Low Molecular Weight Heparin
Heparin, Low-Molecular-Weight
LMWH
Low-Molecular-Weight Heparin

Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective antithrombotic agents. Their administration reduces the risk of hemorrhage, they have a longer half-life, and their platelet interactions are reduced in comparison to unfractionated heparin. They also provide an effective prophylaxis against postoperative major pulmonary embolism.


Type II Keratin
Keratins, Type II
Keratins, Basic
Type II Intermediate Filament Proteins
Keratins, Type 2
Keratin, Type 2

A keratin subtype that includes keratins that are generally larger and less acidic that TYPE I KERATINS. Type II keratins combine with type I keratins to form keratin filaments.


The outermost cytoplasmic layer of the SCHWANN CELLS covering NERVE FIBERS.


Catechol 1,2-Oxygenase
Pyrocatechase
Catechol 1,2-Dioxygenase
Pyrocatechol 1,2-Dioxygenase
Catechol-1,2-Oxygenase

An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.


PDE3 Inhibitors
Phosphodiesterase Type 3 Inhibitors
PDE-3 Inhibitors
Phosphodiesterase 3 Inhibitors

Compounds that specifically inhibit PHOSPHODIESTERASE 3.


A scaffolding protein that is a critical component of the axin signaling complex which binds to ADENOMATOUS POLYPOSIS COLI PROTEIN; GLYCOGEN SYNTHASE KINASE 3; and CASEIN KINASE I.


Voltage-Gated Sodium Channel beta-1 Subunit

A voltage-gated sodium channel beta subunit abundantly expressed in SKELETAL MUSCLE; HEART; and BRAIN. It non-covalently associates with voltage-gated alpha subunits. Defects in the SCN1B gene, which codes for this beta subunit, are associated with generalized epilepsy with febrile seizures plus, type 1, and Brugada syndrome 5.


Bacteroidaceae Infections
Infections, Bacteroidaceae

Infections with bacteria of the family BACTEROIDACEAE.


Bacteria, Blue Green
Algae, Blue-Green
Algae, Blue Green
Cyanobacteria
Blue-Green Algae
Blue-Green Bacteria
Bacteria, Blue-Green
Cyanophyceae
Blue Green Algae
Blue Green Bacteria

A phylum of oxygenic photosynthetic bacteria comprised of unicellular to multicellular bacteria possessing CHLOROPHYLL a and carrying out oxygenic PHOTOSYNTHESIS. Cyanobacteria are the only known organisms capable of fixing both CARBON DIOXIDE (in the presence of light) and NITROGEN. Cell morphology can include nitrogen-fixing heterocysts and/or resting cells called akinetes. Formerly called blue-green algae, cyanobacteria were traditionally treated as ALGAE.


Pectobacterium chrysanthemi
Erwinia chrysanthemi

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that causes vascular wilts on a wide range of plant species. It was formerly named Erwinia chrysanthemi.


Thyroideum Siccatum
Dried Thyroid Extract
Thyroid Extract, Desiccated
Thyroid (USP)
Thyroid Gland, Desiccated
Dried Thyroid
Desiccated Thyroid Extract

A dehydrated extract of thyroid glands from domesticated animals. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.


Left Heart Syndrome, Hypoplastic
Hypoplastic Left Heart Syndrome
Left Heart Hypoplasia Syndrome

A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.


Diethylaminoethyldextran
DEAE-Dextran
Pulsar
DEAE Sephadex

Used as a support for ion-exchange chromatography.


Dimilin Dioflubenzuron TH-6040 Diflubenzuron

An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.


A delicate membrane enveloping the brain and spinal cord. It lies between the PIA MATER and the DURA MATER. It is separated from the pia mater by the subarachnoid cavity which is filled with CEREBROSPINAL FLUID.


Persons whose profession is to give legal advice and assistance to clients and represent them in legal matters. (American Heritage Dictionary, 3d ed)


Animal population groups that produce BIOLOGICAL TOXINS.


Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.


A bone morphogenetic protein that plays an essential role in the regulation of ovarian folliculogenesis.


Iliotibial Band Syndrome
IT Band Syndrome

An overuse injury causing lateral knee pain that results from repetitive friction of the iliotibial band over the lateral femoral epicondyle.


Xylitol Dehydrogenase
D-Xylulose Reductase
NAD-Dependent Xylitol Dehydrogenase

An enzyme that plays a role in the PENTOSES and GLUCURONATES interconversion pathway by catalyzing the oxidation of XYLITOL to D-xylulose. This enzyme has been found to be specific for NAD+.


Transplant Recipients
Transplant Recipient
Recipients, Transplant
Recipient, Transplant

Individuals receiving tissues or organs transferred from another individual of the same or different species, or from within the same individual.


Group D Chromosomes
Chromosomes D
Chromosomes, Human, 13-15

The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.


Sociology of Medicine
Sociology, Medical
Medical Sociology

The study of the social determinants and social effects of health and disease, and of the social structure of medical institutions or professions.


Human Genome Mapping Project
Human Genome Project
Human Genome Diversity Project
Genome Project, Human

A coordinated effort to document the genetic variation of the human species worldwide.


A family of extracellular matrix glycoproteins that is structurally similar to  LATENT TGF-BETA BINDING PROTEINS, but contain additional TGF-beta binding domains, in addition to unique domains at their N and C-terminals. Fibrillins assemble into 10-12 nm MICROFIBRILS that function in a variety of cell interactions with the EXTRACELLULAR MATRIX and developmental processes such as ELASTIC TISSUE maintenance and assembly, and the targeting of growth factors to the extracellular matrix.


Infectious Disease Incubation Period
Incubation Period, Infectious Disease

The amount time between exposure to an infectious agent and becoming symptomatic.


The genetic complement of CHLOROPLASTS as represented in their DNA.


Parodontium
Periodontium
Tooth Supporting Structures
Paradentium

The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.


Retinal-Blood Barrier
Blood-Retinal Barrier

A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.


Student, Premedical
Premedical Students
Premedical Student
Students, Premedical

Individuals enrolled in a preparatory course for medical school.


An enzyme involved in the biosynthesis of isoleucine and valine. It converts 2-acetolactate into 3-hydroxy-2-oxo-isovalerate. Also acts on 2-hydroxy-2-acetobutyrate to form 2-hydroxy-2-oxo-3-methylvalerate. EC 5.4.99.3.


Burns of the respiratory tract caused by heat or inhaled chemicals.


Erythrocyte Filterability
Erythrocyte Deformability

Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.


Rickettsia conorii Infection
Mediterranean Spotted Fever
Boutonneuse Fever

A febrile disease of the Mediterranean area, the Crimea, Africa, and India, caused by infection with RICKETTSIA CONORII.


Edar-Associated Death Domain Protein
Edaradd Protein

A tumor necrosis factor receptor-associated factor that acts as a specific signaling adaptor protein for the EDAR RECEPTOR and plays an important role in ectodermal development. It binds to edar receptor via its C-terminal death domain region and to other specific TNF receptor-associated factors via its N-terminal domain. Loss of function of edar-associated death domain protein is associated with AUTOSOMAL RECESSIVE ANHIDROTIC ECTODERMAL DYSPLASIA.


The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.


An enzyme that catalyzes the conversion of myo-inositol hexakisphosphate and water to 1L-myo-inositol 1,2,3,4,5-pentakisphosphate and orthophosphate. EC 3.1.3.26.


Tooth Sensitivity
Dentine Sensitivity
Dentin Sensitivity
Dentin Hypersensitivity
Dentine Hypersensitivity

Pain associated with exposed DENTIN surfaces of the teeth.


Contraceptive Agents, Male
Contraceptives, Male

Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.


Dermatitis Venenata
Hypersensitivity, Contact
Dermatitis, Contact
Eczema, Contact
Contact Dermatitis
Sensitivity, Contact

A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.


Protein Tyrosine Phosphatase, Non-Receptor Type 13

Protein Tyrosine Phosphatase, Basophil Like

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an amino-terminal FERM domain, an intervening region containing five different PDZ domains, and a carboxyl-terminal phosphatase domain. In addition to playing a role as a regulator of the FAS RECEPTOR activity this subtype interacts via its PDZ and FERM domains with a variety of INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS.


Vascular Calcinosis
Vascular Calcification

Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.


Neoplasms, Squamous Cell
Squamous Cell Cancer
Squamous Cell Neoplasms

Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.


Molecular Diagnostic Testing
Molecular Diagnostic Technics
Molecular Diagnostic Techniques

MOLECULAR BIOLOGY techniques used in the diagnosis of disease.


An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.


Cervix
Cervixes
Cervix Uteri
Uterine Cervix

The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.


A type I keratin found in the basal layer of the adult epidermis and in other stratified epithelia.


Killer Cell Immunoglobulin-Like Receptor 3DS1

Natural Killer-Associated Transcript 10 Protein

An activating KIR receptor that contains D0, D1, and D2 extracellular immunoglobulin-like domains and a short cytoplasmic tail.


FD & C Yellow No. 5
Tartrazine
FD&C Yellow No. 5
Tartrazine Barium (2:3)
Tartrazine Barium

An anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain.


Transforming Growth Factor-beta Type II Receptors

Receptor, Transforming Growth Factor-beta Type II

A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE I TGF-BETA RECEPTORS when bound to TGF-BETA. This receptor complex regulates a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.


Hospitals, Municipal
Hospitals, City, Public-Owned
Hospitals, City, Public Owned
Municipal Hospitals

Hospitals controlled by the city government.


Tumor Necrosis Factor Ligand Superfamily Member 14

Herpesvirus Entry Mediator-Ligand Protein

A member of tumor necrosis factor superfamily found on activated LYMPHOCYTES and MONOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to LYMPHOTOXIN BETA RECEPTOR and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14.


Pneumonia, Bacterial
Bacterial Pneumonia

Inflammation of the lung parenchyma that is caused by bacterial infections.


Receptor Activity-Modifying Protein
Receptor Activity-Modifying Proteins
RAMP Receptor Accessory Proteins

A family of proteins that bind to CELL SURFACE RECEPTORS and alter their specificity, signaling mechanism, or mode of intracellular transport.


Orientia tsutsugamushi Infection
Tsutsugamushi Disease
Typhus, Scrub
Scrub Typhus
Tsutsugamushi Fever

An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash.


Oxyntomodulin
Proglucagon (33-69)
Glicentin (33-69)

A 37-amino acid peptide derived from the C-terminal of GLICENTIN. It is mainly produced by the INTESTINAL L CELLS. Oxyntomodulin can reduce digestive secretions, delay gastric emptying, and reduced food intake.


Acetate Esterase
Acetylesterase
Acetylase
Acid Esterase
Esterase-17

An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1.1.6.


The anterior subdivision of the embryonic PROSENCEPHALON or the corresponding part of the adult prosencephalon that includes the cerebrum and associated structures.


General or unspecified injuries involving the hip.


Necrotizing Arteritis
Polyarteritis Nodosa
Periarteritis Nodosa
Essential Polyarteritis

A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.


Residual Stomach
Gastric Stump
Gastric Remnant
Remnant Stomach

That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump.


Bacterial Secretion Systems
Bacterial Secretion System

In GRAM NEGATIVE BACTERIA, multiprotein complexes that function to translocate pathogen protein effector molecules across the bacterial cell envelope, often directly into the host. These effectors are involved in producing surface structures for adhesion, bacterial motility, manipulation of host functions, modulation of host defense responses, and other functions involved in facilitating survival of the pathogen. Several of the systems have homologous components functioning similarly in GRAM POSITIVE BACTERIA.


Guanosine Monophosphate
Guanylic Acid
5'-Guanylic Acid
Guanosine 5'-Monophosphate
5'-GMP

A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.


Regulation, Gene Expression, Embryologic

Developmental Gene Expression Regulation

Regulation of Gene Expression, Embryologic

Regulation of Gene Expression, Developmental

Regulation, Gene Expression, Developmental

Gene Expression Regulation, Developmental

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.


Abnormal sensitivity to light. This may occur as a manifestation of EYE DISEASES; MIGRAINE; SUBARACHNOID HEMORRHAGE; MENINGITIS; and other disorders. Photophobia may also occur in association with DEPRESSION and other MENTAL DISORDERS.


Kohn-Sham Density Functional Theory
Density Functional Theory
KS-DFT
DFT Calculations

Density functional theory is an approach to describe the electronic ground state properties of matter.  It is a method of obtaining a solution to the Schrodinger equation for a many-body system, and is used to investigate the structural, magnetic, and electronic properties of molecules and materials.


Mouthwashes
Mouth Bath
Mouth Wash
Mouth Rinse

Solutions for rinsing the mouth, possessing cleansing, germicidal, or palliative properties. (From Boucher's Clinical Dental Terminology, 4th ed)


Spartium
Spartium junceum
Broom, Spanish

A plant genus of the family FABACEAE that is a source of SPARTEINE. Do not confuse with Broom or Scotch Broom (CYTISUS) or Butcher's Broom (RUSCUS) or Desert Broom (BACCHARIS) or Brome (BROMUS).


Transplantation, Haploidentical
Haploidentical Transplantation

Transplantation between individuals who share a partial haplotype match.


Heroin Smoking
Heroin Dependence
Heroin Addiction
Heroin Abuse

Strong dependence or addiction, both physiological and emotional, upon HEROIN.


Ultrasonography, Color Doppler
Ultrasonography, Doppler Color
Ultrasonography, Doppler, Color
Doppler Ultrasonography, Color
Doppler Color Ultrasonography
Color Ultrasonography, Doppler
Color Doppler Ultrasonography

Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.


Patient Identification Cards
Health Smart Cards
Smart Cards

Hand-sized cards with built-in computer chips used for accessing, storing, and protecting patients' medical information.


Nerve Growth Factor Receptor, Low-Affinity

A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4.


Syphilis Serodiagnosis
Serodiagnosis, Syphilis
Kahn Test
Wassermann Reaction


Failure Mode and Effect Analysis, Healthcare

Healthcare Failure Mode and Effect Analysis

Prospective risk assessment tool aimed at identifying potential risks and their impact in healthcare settings.


A family of histone molecular chaperones that play roles in sperm CHROMATIN decondensation and CHROMATIN ASSEMBLY in fertilized eggs. They were originally discovered in XENOPUS egg extracts as histone-binding factors that mediate nucleosome formation in vitro.


Equilibrative Nucleoside Transport Proteins

A class of sodium-independent nucleoside transporters that mediate the facilitative transport of NUCLEOSIDES.


The physical distribution of plants in various forms and stages of development through time and space.


Receptors, LDL
Receptors, Low Density Lipoprotein
LDL Receptors, Lipoprotein
Low Density Lipoprotein Receptor
Lipoprotein LDL Receptors
LDL Receptor
LDL Receptors
Receptors, Lipoprotein, LDL
Low Density Lipoprotein Receptors

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.


Hepatitis A Vaccine
Vaqta
Hepatovirus Vaccines
Hepatitis A Vaccines
Havrix

Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).


United States National Program of Cancer Registries

Centers for Disease Control and Prevention National Program of Cancer Registries

National Program of Cancer Registries, U.S.

A unit of the United States Centers for Disease Control and Prevention that supports the collection of high-quality data on cancer occurrence (including the type, extent, and location of the cancer), the type of initial treatment, and outcomes.