delta-Aminolevulinic Acid Synthetase
Aminolevulinic Acid Synthetase
5-Aminolevulinate Synthetase
5-Aminolevulinate Synthase
delta-Aminolevulinate Synthase

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.


Universal Healthcare
Universal Health Care

Access for all people to needed health services (including prevention, promotion, treatment, rehabilitation and palliation) of sufficient quality to be effective while also ensuring that the use of these services does not expose the user to financial hardship. (From https://www.who.int/healthsystems/universal_health_coverage/en/)


Diffuse Intrinsic Pontine Glioma
DIPG, Diffuse Intrinsic Pontine Glioma
DIPG Brain Tumors

A rare, aggressive brain tumor that forms in the GLIAL CELLS in the PONS.


Interracial Relations
Race Relations
Racial Relations

Cultural contacts between people of different races.


Diffusion Tensor Magnetic Resonance Imaging

The tracing of neural or muscle fibers by diffusion tensor imaging.


An order of CRUSTACEA comprised of shrimp-like organisms containing body trunks with at least 20 segments. The are commonly used as aquarium food.


Microvasculature Rarefaction
Vascular Rarefaction
Microvascular Rarefaction
Capillary Rarefaction

The reduction in density of the MICROVASCULATURE.


Swine Influenza
Infections, Orthomyxoviridae
Orthomyxovirus Infections
Orthomyxoviridae Infections
Infections, Orthomyxovirus

Virus diseases caused by the ORTHOMYXOVIRIDAE.


Metabolism, Inborn Errors
Inborn Errors of Metabolism
Metabolism Errors, Inborn

Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.


Voltage-Gated K+ Channel KCNQ1
KCNQ1 Protein
KVLQT1 Protein
KCNQ1 Potassium Channel
Kv7.1 Potassium Channel

A voltage-gated potassium channel that is expressed primarily in the HEART.


Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.


Pentolinium Tartrate
Pentolinium
Pentolonium Tartrate

A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.


Ethylestrenolone Ethylnortestosterone Norethandrolone Nilevar

A synthetic hormone with anabolic and androgenic properties and moderate progestational activity.


Polymyalgia Rheumatica
Pseudopolyarthritis, Rhizomelic
Forestier-Certonciny Syndrome
Rheumatism, Peri-Extra-Articular

A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.


Glucocorticoid Receptor Interacting Protein 120

A heterogeneous-nuclear ribonucleoprotein found associated with the NUCLEAR MATRIX.


An endosymbiont that is either a bacterium or fungus living part of its life in a plant. Endophytes can benefit host plants by preventing pathogenic organisms from colonizing them.


Uridine Diphosphate Glucose
UDPG
Uridine Diphosphoglucose
UDP Glucose

A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.


A type I keratin that is found associated with the KERATIN-1 in terminally differentiated epidermal cells such as those that form the stratum corneum. Mutations in the genes that encode keratin-10 have been associated with HYPERKERATOSIS, EPIDERMOLYTIC.


Invertebrate Peptide Receptors
Peptide Receptors, Invertebrate
Receptors, Peptide, Invertebrate
Invertebrate Peptide Receptor
Receptors, Invertebrate Peptides
Receptors, Invertebrate Peptide

Cell surface receptors for invertebrate peptide hormones or neuropeptides.


Chicken Ovalbumin Upstream Promoter-Transcription Factor II

Nuclear Receptor Subfamily 2, Group F, Member 2

A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.


A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.


An extensive order of basidiomycetous fungi whose fruiting bodies are commonly called mushrooms.


beta-Kallikrein
Padutin
Callicrein
Kallikrein A
alpha-Kallikrein
Kallikrein B'
Dilminal
Kalliginogenase
Kallikreins
Kallikrein
Kallidinogenase
Kininogenase
Kallikrein Light Chain
beta-Kallikrein B
Kinin-Forming Enzyme

Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).


FMLP Receptor
Receptors, Formyl Peptide
F-Chemotactic Peptide Receptor
N-Formylmethionyl Peptide Receptor
fMet-Leu-Phe Receptor
N-formyl Hexapeptide Receptor
Receptor, Chemotactic Peptide
Formyl Peptide Receptor
Chemoattractant Receptor
Chemotactic Peptide Receptor

A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.


Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.


Excision of one or both of the FALLOPIAN TUBES.


Psychiatric Social Work
Psychiatric Social Service
Social Work, Psychiatric
Social Service, Psychiatric

Use of all social work processes in the treatment of patients in a psychiatric or mental health setting.


19-Iodocholest-5-en-3 beta-ol. A cholesterol derivative usually substituted with radioactive iodine in the 19 position. The compound is an adrenal cortex scanning agent used in the assessment of patients suspected of having Cushing's syndrome, hyperaldosteronism, pheochromocytoma and adrenal remnants following total adrenalectomy.


Bovine Serum Albumin
Serum Albumin, Bovine
Bovine Albumin
Albumin Bovine

Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)


Linkage Mapping
Genome Mapping
Chromosome Mapping
Gene Mapping

Any method used for determining the location of and relative distances between genes on a chromosome.


Tumor Necrosis Factor Receptor Superfamily, Member 6

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.


Twelfth Cranial Nerve Diseases
Twelfth Cranial Nerve Disorder
Hypoglossal Neuralgia
Hypoglossal Nerve Diseases
Hypoglossal Nerve Palsy
Hypoglossal Neuropathy
Cranial Nerve XII Diseases
Cranial Nerve XII Disorders

Diseases of the twelfth cranial (hypoglossal) nerve or nuclei. The nuclei and fascicles of the nerve are located in the medulla, and the nerve exits the skull via the hypoglossal foramen and innervates the muscles of the tongue. Lower brain stem diseases, including ischemia and MOTOR NEURON DISEASES may affect the nuclei or nerve fascicles. The nerve may also be injured by diseases of the posterior fossa or skull base. Clinical manifestations include unilateral weakness of tongue musculature and lingual dysarthria, with deviation of the tongue towards the side of weakness upon attempted protrusion.


Natural Cytotoxicity Triggering Receptors

Receptors, Natural Cytotoxicity Triggering

A subclass of natural killer cell receptors that perform an important role in the recognition of tumor cells by NK CELLS.


Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.


Local Neoplasm Recurrence
Neoplasm Recurrence, Locoregional
Recurrence, Local Neoplasm
Recurrence, Locoregional Neoplasm
Neoplasm Recurrences, Local
Recurrences, Local Neoplasm
Locoregional Neoplasm Recurrence
Neoplasm Recurrence, Local
Local Neoplasm Recurrences

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.


Perforating Fasciculus
Perforant Path
Perforant Pathway

A pathway of fibers that originates in the lateral part of the ENTORHINAL CORTEX, perforates the SUBICULUM of the HIPPOCAMPUS, and runs into the stratum moleculare of the hippocampus, where these fibers synapse with others that go to the DENTATE GYRUS where the pathway terminates. It is also known as the perforating fasciculus.


Glucagon Receptors
Glucagon Receptor
Receptors, Glucagon

Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.


Ribonucleoprotein Domain
RNA Recognition Motif
RRM Motif

An approximately 80 amino acid RNA binding motif that consists of four anti-parallel surface beta sheets and two alpha helices arranged in a beta-alpha-beta-beta-alpha-beta configuration. One of the surface beta sheets interacts with two or three specific RNA bases. Interactions between additional sequences and the RNA, as well as within the RNA recognition motif increase the affinity and specificity of the protein-RNA interaction.


Neuronally Expressed EPH-Related Tyrosine Kinase

An eph family receptor found primarily in the nervous system. In the embryonic BRAIN EphB1 receptor expression occurs in the mantle layer and increases with the progression of embryogenesis. In adult brain it is found in the several regions including the CEREBELLUM; CEREBRAL CORTEX; and CAUDATE NUCLEUS; and PUTAMEN.


Techniques, Respiratory System Diagnostic

Technique, Respiratory System Diagnostic

Respiratory System Diagnostic Techniques

Diagnostic Techniques, Respiratory System

Diagnostic Technique, Respiratory System

Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.


Rhabdomyosarcoma 2
Rhabdomyosarcoma, Alveolar

A form of RHABDOMYOSARCOMA occurring mainly in adolescents and young adults, affecting muscles of the extremities, trunk, orbital region, etc. It is extremely malignant, metastasizing widely at an early stage. Few cures have been achieved and the prognosis is poor. "Alveolar" refers to its microscopic appearance simulating the cells of the respiratory alveolus. (Holland et al., Cancer Medicine, 3d ed, p2188)


Ribonucleoproteins, Small Cytoplasmic
Small Cytoplasmic Ribonucleoproteins
scRNP

Complexes of scRNA (RNA, SMALL CYTOPLASMIC) and protein found in the cytoplasm. An example is SIGNAL RECOGNITION PARTICLE.


Carapace
Seashells
Animal Shells
Animal Exoskeleton

Shells of marine animals most often composed of CALCIUM CARBONATE.


Mucous Membrane
Muscularis Mucosae
Mucosal Tissue
Lamina Propria
Mucous Membranes
Mucosa

An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.


Bardet-Biedl Syndrome
Laurence-Moon-Bardet-Biedl Syndrome

An autosomal recessive disorder characterized by RETINITIS PIGMENTOSA; POLYDACTYLY; OBESITY; MENTAL RETARDATION; hypogenitalism; renal dysplasia; and short stature. This syndrome has been distinguished as a separate entity from LAURENCE-MOON SYNDROME. (From J Med Genet 1997 Feb;34(2):92-8)


Atretic Follicle
Graafian Follicle
Ovarian Follicle
Ovarian Follicles

A degenerating ovarian follicle as a result of atresia (FOLLICULAR ATRESIA). During atresia, the OOCYTE and GRANULOSA CELLS within the basal lamina die and are replaced by fibrous tissue.


Protein Arginine Deiminase Type III
Protein Arginine Deiminase 3
Protein-Arginine Deiminase Type 3
Peptidyl Arginine Deiminase Type III
Peptidylarginine Deiminase III
Protein-Arginine Deiminase Type III
Peptidyl Arginine Deiminase Type 3
Protein Arginine Deiminase Type 3
PADI3 Protein
Peptidylarginine Deiminase Type III
Peptidylarginine Deiminase Type 3

A post-translational enzyme that catalyzes the conversion of protein bound arginine residues to CITRULLINE residues in a CALCIUM ion-dependent manner. PADI3 is a peptidylarginine deiminase isoenzyme expressed in epidermal tissue.


Neutralizing Antibody
Neutralizing Antibodies
Antibody, Neutralizing
Antibodies, Neutralizing

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.


Blood Platelet Disorders
Thrombocytopathy

Disorders caused by abnormalities in platelet count or function.


T-Rays
THz Radiation
Terahertz Radiation

Non-ionizing electromagnetic energy in the frequency range of 100 gigahertz to 10 terahertz which spans from the mid-INFRARED RAYS frequency to the high-frequency edge of the MICROWAVES band.


Mothers Against Decapentaplegic Homolog
Smad Proteins
Sma- and Mad-Related Proteins

A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.


Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.


A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)


Central Nervous System Agents
Central Nervous System Drugs

A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)


An enzyme that catalyzes the formation of N-5'-phosphoribosylanthranilic acid from anthranilate and phosphoribosylpyrophosphate, the first step in tryptophan synthesis in E. coli. It exists in a complex with ANTHRANILATE SYNTHASE in bacteria. EC 2.4.2.18.


Trimedoxime
Dipyroxime
Trimedoxime Bromide
TMB-4

Cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.


Genotype Determination Methods
Genotype Assignment Methodology
Genotype Calling Methods
Genotyping Techniques

Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).


Owl Monkey
Aotus
Night Monkey
Monkey, Owl
Monkey, Night
Aotidae
Aotinae
Douroucouli

A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus (Aotus) and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).


A complication of OBSTETRIC LABOR in which the corpus of the UTERUS is forced completely or partially through the UTERINE CERVIX. This can occur during the late stages of labor and is associated with IMMEDIATE POSTPARTUM HEMORRHAGE.


The final period of OBSTETRIC LABOR that is from the expulsion of the FETUS to the expulsion of the PLACENTA.


Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.


Src Homology 2 Domain-Containing, Transforming Protein 3

SHC3 (Src Homology 2 Domain-Containing) Protein

Src Homology 2 Domain-Containing-Transforming Protein C3

An SHC-signaling adaptor protein that links GROWTH FACTOR RECEPTORS to SIGNAL TRANSDUCTION PATHWAYS in neurons, including NEUROTROPHINS signaling in the CENTRAL NERVOUS SYSTEM.


Purinergic Receptor P2X, Ligand-Gated Ion Channel, 5

A purinergic P2X neurotransmitter receptor found at high levels in the BRAIN and IMMUNE SYSTEM.


Chlamydia psittaci
Chlamydophila psittaci

A genus of CHLAMYDOPHILA infecting primarily birds. It contains eight known serovars, some of which infect more than one type of host, including humans.


Achievement of full sexual capacity in animals and in humans.


Autonomy, Personal
Free Will
Personal Autonomy
Self Determination

Self-directing freedom and especially moral independence. An ethical principle holds that the autonomy of persons ought to be respected. (Bioethics Thesaurus)


Protein Tyrosine Phosphatase, Nonreceptor Type 6

Hematopoietic Cell-Specific Tyrosine Phosphatase SHP-1

Protein Tyrosine Phosphatase, Non-Receptor Type 6

A Src-homology domain-containing protein tyrosine phosphatase found in the CYTOSOL of hematopoietic cells. It plays a role in signal transduction by dephosphorylating signaling proteins that are activated or inactivated by PROTEIN-TYROSINE KINASES.


An absence of warmth or heat or a temperature notably below an accustomed norm.


Nettle, Hedge
Betonica
Hedgenettle
Stachys

A plant genus of the family LAMIACEAE that has a characteristic odor.


RBL1 Protein
Retinoblastoma-Like Protein 1
Retinoblastoma Like Protein p107
p107 Tumor Suppressor Protein
Retinoblastoma-Like Protein p107

A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. It contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.


Aminooxyacetate
Carboxymethoxyamine
Aminooxyacetic Acid

A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.


E2F Dimerization Partner 1
Transcription Factor DP1
DRTF1b Transcription Factor
TFDP1 Protein
DP1 Protein
Transcription Factor DP-1
Dimerization Partner 1 Protein
DRTF1c Transcription Factor
DP-1 Transcription Factor
DRTF1a Transcription Factor
Transcription Factor DRTF1
DRTF1 Transcription Factor

A transcription factor that possesses DNA-binding and E2F-binding domains but lacks a transcriptional activation domain. It is a binding partner for E2F TRANSCRIPTION FACTORS and enhances the DNA binding and transactivation function of the DP-E2F complex.


Single-Chain Variable Fragment Antibodies

A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.


The condition of carrying two or more FETUSES simultaneously.


Zinc Cysteinate
L-Cysteine
Half-Cystine
Cysteine
Cysteine Hydrochloride

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.


Nuclear Factor (Erythroid-Derived 2)-Like 1 Protein

A basic-leucine zipper transcription factor that is involved in regulating inflammatory responses, MORPHOGENESIS, and HEME biosynthesis.


Facial Paralysis, Idiopathic
Herpetic Facial Paralysis
Bell's Palsy
Acute Idiopathic Facial Neuropathy
Idiopathic Acute Facial Neuropathy
Facial Neuropathy, Idiopathic Acute
Facial Neuropathy, Inflammatory, Acute
Inflammatory Facial Neuropathy, Acute
Bell Palsy
Acute Inflammatory Facial Neuropathy

A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376)


Chromosome 16
Chromosomes, Human, Pair 16

A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.


The use of chemical compounds to prevent the development of a specific disease.


A plant genus of the family BRASSICACEAE that includes several marshy plants. The common name of watercress is also used for NASTURTIUM & TROPAEOLUM.


Prolactin Receptors
Receptors, Prolactin
Receptors, PRL
PRL Receptors
Prolactin Receptor

Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor.


pp60(c-src)
pp60 c-src
Proto-Oncogene Protein pp60(c-src)
Proto-Oncogene Protein src
src Proto-Oncogene Product
src Proto-Oncogene Protein pp60
c-src Protein pp60
Phosphoprotein pp60(c-src)
Proto-Oncogene Proteins pp60(c-src)

Membrane-associated tyrosine-specific kinases encoded by the c-src genes. They have an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to PP60(V-SRC) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase.


Hydrogenated alprenolol derivative where the extra hydrogens are often tritiated. This radiolabeled form of ALPRENOLOL, a beta-adrenergic blocker, is used to label the beta-adrenergic receptor for isolation and study.


Sexual Intercourse
Coitus
Coital Frequency
First Intercourse

The sexual union of a male and a female, a term used for human only.


Intoxication, Alcoholic
Drunkenness
Alcoholic Intoxication

An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.


HLA Class I Histocompatibility Antigen, A-3 alpha Chain

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*03 allele family.


mRNA Cap Binding Proteins
Cap-Binding Protein Complex
RNA Cap-Binding Proteins
Cap Binding Proteins
RNA Cap Binding Proteins
Cap Binding Protein

A heterodimeric protein complex of RNA cap-binding proteins which binds with high affinity to the 5' MRNA CAP STRUCTURE.


Social Communication Disorder
Pragmatic Communication Disorder

Persistent difficulties in the social uses of verbal and nonverbal communications. (DSM-V)


Twist Family Bhlh Transcription Factor 1

A basic helix-loop-helix transcription factor that was originally identified in DROSOPHILA as essential for proper gastrulation and MESODERM formation. It plays an important role in EMBRYONIC DEVELOPMENT and CELL DIFFERENTIATION of MUSCLE CELLS, and is found in a wide variety of organisms.


Hypertrophic Chondrocyte-Specific Protein 24

Insulin-Like Growth Factor Binding Protein 8

A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.


Biomimicry Engineering
Mimetics, Biological
Biomimicry Science
Bio-inspired Engineering
Biomimetics

An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.


Maximum Permissible Exposure Concentration

The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed)


Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.


A class of Arthropoda that includes SPIDERS; TICKS; MITES; and SCORPIONS.


Hemangio-Endothelioma
Hemangioendothelioma
Endothelioma, Vascular

A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)


Aged Nutritional Physiological Phenomena

Elder Nutritional Physiological Phenomenon

Elderly Nutrition Physiological Phenomena

Elder Nutritional Physiological Phenomena

Nutritional physiology of adults aged 65 years of age and older.


An anticonvulsant that is the active metabolite of TRIMETHADIONE.


Insulin-Like Growth Factor Binding Protein 6

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.


Malalignment of a bone in which its head and neck is rotated excessively forward or inward.


Variation Analysis, Small-Area
Small-Area Variation Analysis
Small-Area Studies
Analysis, Small-Area
Small-Area Variation
Small-Area Analysis

A method of analyzing the variation in utilization of health care in small geographic or demographic areas. It often studies, for example, the usage rates for a given service or procedure in several small areas, documenting the variation among the areas. By comparing high- and low-use areas, the analysis attempts to determine whether there is a pattern to such use and to identify variables that are associated with and contribute to the variation.


Folic Acid Deficiency
Deficiency, Folic Acid

A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)


Muscle Development
Muscular Development
Myogenesis
Myofibrillogenesis

The developmental sequence of events in the formation of adult muscle tissue, including fusion of myoblasts to form myotubes, the formation of MYOFIBRILS within their cytoplasm, and the establishment of functional neuromuscular junctions (NEUROMUSCULAR JUNCTION) with MOTOR NEURONS.


Emergency Responders
Emergency First Responders
First Responders

Personnel trained to provide the initial services, care, and support in EMERGENCIES or DISASTERS.


Klatskin Tumor
Klatskin's Tumor
Perihilar Cholangiocarcinoma
Hilar Cholangiocarcinoma

Cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts (COMMON HEPATIC DUCT). These tumors are generally small, sharply localized, and seldom metastasizing.


A deoxycytidine analog and REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B viruses. It is used to treat HIV INFECTIONS.


Hookworms
Ancylostomatoidea
Bunostomum
Uncinaria stenocephala

A superfamily of nematode parasitic hookworms consisting of four genera: ANCYLOSTOMA; NECATOR; Bunostomum; and Uncinaria. ANCYLOSTOMA and NECATOR occur in humans and other mammals. Bunostomum is common in ruminants and Uncinaria in wolves, foxes, and dogs.


Receptors, Calcium Channel Blocker
Calcium Channel Blocker Receptor
Calcium Channel Blocker Receptors
Receptors, Calcium Channel Antagonist
VDCC
Calcium Channels
Calcium Channel
Calcium Channel Antagonist Receptor
Voltage-Dependent Calcium Channels
Ion Channel, Calcium
Ion Channels, Calcium
Calcium Channel Antagonist Receptors

Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.


Tryptophan Monooxygenase
Tryptophan Hydroxylase

An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.


Animals, Domestic
Farm Animals
Domestic Animals
Domesticated Animals

Animals which have become adapted through breeding in captivity to a life intimately associated with humans. They include animals domesticated by humans to live and breed in a tame condition on farms or ranches for economic reasons, including LIVESTOCK (specifically CATTLE; SHEEP; HORSES; etc.), POULTRY; and those raised or kept for pleasure and companionship, e.g., PETS; or specifically DOGS; CATS; etc.


Perfenazine Trilafon Chlorpiprazine Perphenazine

An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.


Disintegrin and Metalloproteinase Domain-Containing Protein 17

Tumor Necrosis Factor-alpha Converting Enzyme

A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.


Pseudohermaphroditism, Nephron Disorder and Wilms' Tumor

Nephropathy, Wilms Tumor, and Genital Anomalies

A disorder of sex development characterized by UROGENITAL ABNORMALITIES; GONADAL DYSGENESIS; and WILMS TUMOR. It is caused by a mutation in the Wilms tumor suppressor gene (GENES, WILMS TUMOR) on chromosome 11.


The use of computational and data retrieval techniques in understanding problems of chemistry. Cheminformatics strategies are useful in high throughput drug discovery.


Ankylosis, Tooth
Ankylosis of Teeth
Ankylosis, Dentoalveolar
Dentoalveolar Ankylosis
Dental Ankylosis
Tooth Ankylosis

Solid fixation of a tooth resulting from fusion of the cementum and alveolar bone, with obliteration of the periodontal ligament. It is uncommon in the deciduous dentition and very rare in permanent teeth. (Jablonski's Dictionary of Dentistry, 1992)


Striatonigral Atrophy
Striatonigral Degeneration

A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)


Compounds with triple bonds to each side of a double bond. Many of these are CYTOTOXINS and are researched for use as CYTOTOXIC ANTIBIOTICS.


Mönckeberg's Sclerosis
Monckeberg's Sclerosis
Sclerosis, Mönckeberg Medial Calcific
Mönckeberg's Medial Calcific Sclerosis
Medial Calcific Sclerosis
Monckeberg Medial Calcific Sclerosis
Monckeberg's Medial Calcific Sclerosis
Mönckeberg Medial Calcific Sclerosis
Sclerosis, Monckeberg Medial Calcific

Thickening and loss of elasticity of the walls of muscular ARTERIES due to calcification of the TUNICA MEDIA, the concentric layers of helically arranged SMOOTH MUSCLE CELLS.


Oil extracted from fruit of the OLIVE TREE (genus Olea).


p62 c-myc
myc Proto-Oncogene Product p62
Proto-Oncogene Proteins myc
Proto-Oncogene Proteins c-myc
N-myc Proteins
L-myc Proteins
myc Proto-Oncogene Proteins
Proto-Oncogene Products c-myc
p62(c-myc)
c-myc Proteins

Basic helix-loop-helix transcription factors encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.


Antibodies, Bacterial
Bacterial Antibodies

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.


Species infecting goldfish, in the family IRIDOVIRIDAE, unassigned to specific genera.


Forkhead in Rhabdomyosarcoma-Like 1 Protein

A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.


Infections and Infestations
Infections
Infection and Infestation
Infection

Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.


Autocrine Signaling
Autocrine Communication

Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.


A metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. It has antineoplastic properties, including inhibition of angiogenesis and induction of APOPTOSIS.


A human leukemia monocytic cell line derived from a patient with LEUKEMIA, MONOCYTIC, ACUTE. It is used as a model to study the function of MONOCYTES and MACROPHAGES, their signaling pathways, nutrient and drug transport.


Brachial Plexus Anesthesia
Brachial Plexus Block
Brachial Plexus Blockade

A blocking of NEURAL CONDUCTION in the network of nerve fibers innervating the UPPER EXTREMITY.


The prelarval stage of Filarioidea found in the blood and tissues of mammals, birds and intermediate hosts (vector).


Stress-Activated Protein Kinase 2
SAPK2b
p38beta MAP Kinase
Mitogen-Activated Protein Kinase 11
SAPK2
Stress-Activated Protein Kinase 2b
MAPK11 Mitogen-Activated Protein Kinase
p38(beta) MAP Kinase
Mitogen-Activated Protein Kinase Eleven
SAP Kinase-2

A 38-kDa mitogen-activated protein kinase that is expressed in a broad variety of cell types. It may play a role in regulating cell proliferation and TRANSCRIPTION FACTOR AP-1 dependent transcription.


Mole-Rats
Molerats
Cryptomys
Mole Rats
Heterocephalus

Any of several burrowing rodents of the families MURIDAE and Bathyergidae, found in eastern Europe, Africa, and Asia. They have short limbs, small eyes with permanently closed lids, and no tail. Three genera SPALAX (Muridae), Heterocephalus (Bathyergidae) and Cryptomys (Bathyergidae) are used frequently as experimental animals in biomedical research. (From Walker's Mammals of the World, 6th ed)


Paroxysmal Atrial Fibrillation
Familial Atrial Fibrillation
Auricular Fibrillation
Atrial Fibrillation
Persistent Atrial Fibrillation

Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.


Purinergic Receptor Agonists
Purinergic Agonists
Purinoceptor Agonists

Compounds that bind to and activate PURINERGIC RECEPTORS.


An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.


Tooth, Primary
Primary Teeth
Teeth, Primary
Dentition, Primary
Milk Tooth
Milk Teeth
Baby Teeth
Baby Tooth
Tooth, Deciduous
Teeth, Deciduous
Dentition, Deciduous
Primary Tooth

The teeth of the first dentition, which are shed and replaced by the permanent teeth.


Abelson murine leukemia virus
Abelson Leukemia Virus

A replication-defective strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with FRIEND MURINE LEUKEMIA VIRUS; MOLONEY MURINE LEUKEMIA VIRUS; or RAUSCHER VIRUS.


Psychiatric Emergency Services
Emergency Psychiatric Services
Services, Emergency Psychiatric
Emergency Services, Psychiatric
Services, Psychiatric Emergency

Organized services to provide immediate psychiatric care to patients with acute psychological disturbances.


Surface Antigen
Surface Markers, Immunological
Immunologic Surface Markers
Surface Markers, Immunologic
Markers, Immunological Surface
Antigens, Surface
Cell Surface Antigen
Cell Surface Antigens
Surface Antigens

Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.


Olfactory Sensory Neurons
Olfactory Receptor Neuron
Olfactory Sensory Cells
Olfactory Sensory Cilia
Neurons, Olfactory Receptor
Olfactory Receptor Neurons
Olfactory Receptor Cells

Neurons in the OLFACTORY EPITHELIUM with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. These neurons send their DENDRITES to the surface of the epithelium with the odorant receptors residing in the apical non-motile cilia. Their unmyelinated AXONS synapse in the OLFACTORY BULB of the BRAIN.


MSX1 Transcription Factor
Msh Homeo Box Homolog 1 Protein
Homeobox 7.1 Protein

A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS.


Ciliophora Infections
Infections, Ciliophora

Infections with protozoa of the phylum CILIOPHORA.


Alphaviruses
Alphavirus
Arboviruses, Group A
Alpha Virus
Getah virus
Barmah forest virus

A genus of TOGAVIRIDAE, also known as Group A arboviruses, serologically related to each other but not to other Togaviridae. The viruses are transmitted by mosquitoes. The type species is the SINDBIS VIRUS.


Clostridium botulinum F
Clostridium botulinum type F

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type F which is neurotoxic to humans and animals.


Gasser Syndrome
Gasser's Syndrome
Hemolytic-Uremic Syndrome

A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.


Muscle Tissue Neoplasms
Myoblastoma
Neoplasms, Muscle Tissue
Myofibroblastoma

Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.


Chronic Fatigue and Immune Dysfunction Syndrome

Infectious Mononucleosis-Like Syndrome, Chronic

A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)


Valine-tRNA Ligase
Valyl T RNA Synthetase
Val-tRNA Ligase
Valyl-tRNA Synthetase

An enzyme that activates valine with its specific transfer RNA. EC 6.1.1.9


A sugar alcohol formed by the reduction of ribose.


Healthcare Facilities, Manpower, and Services

Health Care Facilities, Manpower, and Services

The services provided in the delivery of health care, associated facilities in health care, and attendant manpower required or available.


Axonal Pathfinding
Neural Guidance
Neural Pathfinding
Axon Pathfinding
Axon Guidance
Neurite Guidance
Neuronal Guidance
Neuronal Pathfinding

The mechanism by which a neuronal process outgrows toward a target led by the GROWTH CONE. Local guidance cues are provided by cell surface proteins that act on the growing axon.


Leukemia, Prolymphocytic, B-Cell
B-Cell Prolymphocytic Leukemia

A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.


The stage in the first meiotic prophase, following ZYGOTENE STAGE, when CROSSING OVER between homologous CHROMOSOMES begins.


Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

Syndrome with clinical features of both ASTHMA and COPD.


Menorrhagia
Heavy Menstrual Bleeding
Heavy Periods
Hypermenorrhea

Excessive uterine bleeding during MENSTRUATION.


IUD Expulsion
Intrauterine Device Expulsion

Spontaneous loss of INTRAUTERINE DEVICES from the UTERUS.


Study of past events and development in the field of DENTISTRY.


Persons with loss of vision such that there is an impact on activities of daily living.


Adenosine Pyrophosphateglucose
ADPG
Adenosine Diphosphate Glucose
ADP Glucose
Adenosine Diphosphoglucose

Serves as the glycosyl donor for formation of bacterial glycogen, amylose in green algae, and amylopectin in higher plants.


A-raf Protein Kinase
A-raf Kinase
Proto-Oncogene Proteins A-raf
Proto-Oncogene Protein A-raf
A-raf-1 Protein

A raf kinase subclass expressed primarily in non-neuronal tissues such as SKELETAL MUSCLE. The A-raf kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1.


Administration Schedule, Drug
Drug Administration Schedule

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.


A genus of CRUSTACEA of the order ANOSTRACA, found in briny pools and lakes and often cultured for fish food. It has 168 chromosomes and differs from most crustaceans in that its blood contains hemoglobin.


Methods of preparing cells or tissues for examination and study of their origin, structure, function, or pathology. The methods include preservation, fixation, sectioning, staining, replica, or other technique to allow for viewing using a microscope.


A combination of the debris index and the dental calculus index to determine the status of oral hygiene.


Cyclosporin-Binding Proteins
Cyclophilins
Cyclophilin
Cyclosporin-Binding Protein

A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-


Creativity
Creative Ability
Creative Thinking
Creativeness
Artistic Creativity

A quality that humans can possess involving the ability to make, create, or perform.


C5a, des-Arg
Complement 5a, de-Arginine
Complement 5a, des-Arginine
C5a des-Arginine
C5 a, des-Arg
C5a des-Arg
C5 a, des-Arginine
Complement C5a, des-Arginine
C5a, des-Arginine

A derivative of complement C5a, generated when the carboxy-terminal ARGININE is removed by CARBOXYPEPTIDASE B present in normal human serum. C5a des-Arg shows complete loss of spasmogenic activity though it retains some chemotactic ability (CHEMOATTRACTANTS).


Rats, Lew
Rats, Inbred Lewis
Rats, Inbred Lew

An inbred strain of rat that is used in BIOMEDICAL RESEARCH.


A plant genus of the family RUBIACEAE. It is best known for the COFFEE beverage prepared from the beans (SEEDS).


Trypsin Inhibitor Kunitz Soybean
Trypsin Inhibitor, Kunitz Soybean
Kunitz Soybean Trypsin Inhibitor
Trypsin Inhibitor DE-3

A high-molecular-weight protein (approximately 22,500) containing 198 amino acid residues. It is a strong inhibitor of trypsin and human plasmin.


A plant genus of the family RANUNCULACEAE.


Karnofsky Performance Status
Karnofsky Scale
Karnofsky Index
Karnofsky Performance Status Scale

A performance measure for rating the ability of a person to perform usual activities, evaluating a patient's progress after a therapeutic procedure, and determining a patient's suitability for therapy. It is used most commonly in the prognosis of cancer therapy, usually after chemotherapy and customarily administered before and after therapy. It was named for Dr. David A. Karnofsky, an American specialist in cancer chemotherapy.


Nucleosome-Remodeling Factor Subunit RBAP48

p48 Subunit, Chromatin Assembly Factor-1

A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2.


Complement Activation Pathway, Classical

Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.


The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.


Methylmercadone Inimur Thiodinon Nifuratel Macmiror Metilmercadon

Local antiprotozoal and antifungal agent that may also be given orally.


Hospital Laboratories
Laboratories, Hospital
Laboratory, Hospital
Hospital Laboratory

Hospital facilities equipped to carry out investigative procedures.


Replantation, Surgical
Surgical Replantation
Replantation
Reimplantation

Restoration of an organ or other structure to its original site.


A ubiquitously-expressed cysteine peptidase that exhibits carboxypeptidase activity. It is highly expressed in a variety of immune cell types and may play a role in inflammatory processes and immune responses.


A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage.


3-Hydroxysteroid Dehydrogenases
3 Hydroxysteroid Dehydrogenases
3-beta-Hydroxysteroid Dehydrogenase

Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.


Inflammation of the KIDNEY PELVIS and the URINARY BLADDER.


Drug Dosing Biomarkers
Biological Markers, Pharmacological
Drug Safety Biomarkers
Drug Response Biomarkers
Biomarkers, Pharmacological

Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).


Token Reinforcement
Token Economy
Economy, Token

A practice whereby tokens representing money, toys, candy, etc., are given as secondary reinforcers contingent upon certain desired behaviors or performances.


gp41 Envelope Protein, HIV
HIV Envelope Protein gp41
gp41(HIV)
HTLV-III gp41
Envelope Protein gp41, HIV
HIV Transmembrane Protein gp41
env Protein gp41, HIV

Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. It has a molecular weight of 41,000 and is glycosylated. The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. Gp41 is one of the most common HIV antigens detected by IMMUNOBLOTTING.


Encapsulating Peritoneal Sclerosis
Peritoneal Fibrosing Syndrome
Peritoneal Sclerosis
Peritoneal Fibrosis

Disorder characterized by a wide range of structural changes in PERITONEUM, resulting from fibrogenic or inflammatory processes. Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency.


ATRX Protein
RAD54 Homolog Protein
X-linked Nuclear Protein

ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).


A cell line derived from cultured tumor cells.


2S Albumins, Plant
2S Storage Albumins, Plant

A major class of water-soluble seed storage proteins. Many proteins from this class are major PLANT ALLERGENS.


Medical Centers, Academic
Center, University Medical
Academic Medical Centers
Centers, Academic Medical
Medical Center, Academic
Medical Center, University
University Medical Centers
Medical Centers, University
Academic Medical Center
Centers, University Medical
Center, Academic Medical
University Medical Center

Medical complexes consisting of medical school, hospitals, clinics, libraries, administrative facilities, etc.


Job Stress
Workplace Stress
Occupational Stress
Job-related Stress
Work-related Stress
Work Place Stress
Professional Stress

Adverse psychological and behavioral reactions caused by the pressures and demands of employers or clients or other factors, such as the physical environment of the workplace, WORKPLACE VIOLENCE; or WORKPLACE BULLYING.


Mitochondrial Inheritance
Genes, Mitochondrial
Mitochondrial Genes

Genes that are located on the MITOCHONDRIAL DNA. Mitochondrial inheritance is often referred to as maternal inheritance but should be differentiated from maternal inheritance that is transmitted chromosomally.


A plant genus of the family POACEAE. The name is similar to Broom or Scotch Broom (CYTISUS) or Butcher's Broom (RUSCUS) or Desert Broom (BACCHARIS) or Spanish Broom (SPARTIUM).


Cell-Matrix Junctions
Cell-Matrix Adhesions

Specialized areas at the CELL MEMBRANE where a cell attaches to the EXTRACELLULAR MATRIX or other substratum.


Histone Methyltransferase
Histone H3 Methyltransferase
Histone Methyltransferases
Histone Methylase
Histone-Arginine N-Methyltransferase

Enzymes that catalyze the transfer of methyl groups to LYSINE or ARGININE residues of HISTONES, especially histone H3 and histone H4 proteins. They play a critical role in EPIGENETIC PROCESSES.


Hexanols
Alcohols, Hexyl
Amylcarbinols
Hydroxyhexanes

Isomeric forms and derivatives of hexanol (C6H11OH).


Cardiac Life Support, Advanced
Life Support, Advanced Cardiac
Advanced Cardiac Life Support

The use of sophisticated methods and equipment to treat cardiopulmonary arrest. Advanced Cardiac Life Support (ACLS) includes the use of specialized equipment to maintain the airway, early defibrillation and pharmacological therapy.


(5-HT)2B Receptors
Receptor, Serotonin 2B
Serotonin 2B Receptor
Serotonin 2B Receptors
5-Hydroxytryptamine 2B Receptor
Receptor, Serotonin, 5-HT2B
5-HT2B Receptor

A serotonin receptor subtype found in the BRAIN; HEART; LUNGS; PLACENTA and DIGESTIVE SYSTEM organs. A number of functions have been attributed to the action of the 5-HT2B receptor including the development of cardiac myocytes (MYOCYTES, CARDIAC) and the contraction of SMOOTH MUSCLE.


A large diverse group of membrane transport proteins whose families are generally classified according to function. Most SLCs localize to the CELL MEMBRANE; however, some families such as SLC25, localize to MITOCHONDRIAL MEMBRANES or other ORGANELLES.


Syndecan4
Ryudocan Core Protein
Syndecan-4
Ryudocan
Amphiglycan
Syndecan 4

A ubiquitously expressed syndecan that is found in all stages of embryonic development and in most adult tissues. Syndecan-4 is found localized to focal adhesion sites in fibronectin-adherent cells and may play a role the process of CELL MIGRATION and CELL PROLIFERATION.


The process of giving birth to one or more offspring.


Space Maintenance
Space Maintenance, Orthodontic

Common treatment method used in pediatric dentistry that involves the use of fixed or removable space maintainers in order to keep the space left by a baby tooth safe in the event it is lost early. Space maintainers also help permanent teeth to grow safely.


Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-

A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.


Therapy, Marital
Therapy, Marriage
Marriage Therapy
Marital Therapy

A form of psychotherapy involving both spouses and directed to improving the marital relationship.


Post-acute Care
Subacute Care
Postacute Care
Sub-Acute Care

Medical and skilled nursing services provided to patients who are not in an acute phase of an illness but who require a level of care higher than that provided in a long-term care setting. (JCAHO, Lexikon, 1994)


Microsomal Triglyceride Transfer Protein Deficiency Disease

An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.


Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome

A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.


DET
N,N-Diethyl-3-methylbenzamide
N,N-Diethyltoluamide
DEET
N,N-Diethyl-m-toluamide
R-209
DEET, 2,5-di-Me-Analog
DETA
N,N-Diethyl-2,5-dimethylbenzamide

A compound used as a topical insect repellent that may cause irritation to eyes and mucous membranes, but not to the skin.


Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.


Musculoskeletal Development
Musculoskeletal System Development

The morphologic and physiological changes of the MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body, i.e., MUSCULOSKELETAL SYSTEM, during the prenatal and postnatal stages of development.


Injuries to the fibrous cords of connective tissue which attach muscles to bones or other structures.


Parathion Methyl
Metacid 50
Dalf
Metaphos
Methylparathion
Wofatox
Methyl Parathion
Vofatox

The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.


Aortic Stenosis, Subvalvular
Subvalvular Aortic Stenosis
Aortic Subvalvular Stenosis

A pathological constriction occurring in the region below the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.


Temperature, Transition
Freezing Point Temperature
Boiling Point Temperature
Transition Temperature
Melting Point Temperature

The temperature at which a substance changes from one state or conformation of matter to another.


Hemato-Encephalic Barrier
Brain-Blood Barrier
Blood-Brain Barrier

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.


Fecal Incontinence
Fecal Soiling
Bowel Incontinence

Failure of voluntary control of the anal sphincters, with involuntary passage of feces and flatus.


Syncope, Effort
Syncopal Episode
Syncope, Tussive
Syncope, Situational
Syncope, Carotid Sinus
Drop Attack
Syncope, Micturition
Syncope, Hyperventilation
Syncope, Convulsive
Syncope, Postural
Fainting
Syncope, Cardiogenic
Syncopal Vertigo
Syncope
Syncope, Stokes-Adams
Syncope, Deglutitional
Presyncope

A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)


Animal Experiments
Animal Experimental Use
Animal Research
Animal Experimentation

The use of animals as investigational subjects.


Broca's Area
Pars Opercularis
Pars Triangularis
Broca's Region
Broca's Speech Area
Broca Area

Functional neuroanatomical region of the inferior frontal gyrus consisting of pars opercularis and pars triangularis. It is important in SPEECH and LANGUAGE production. Injuries to Broca area are associated with BROCA APHASIA and APRAXIA.


A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora.


beta-Adrenergic Receptor Kinase 2
G-Protein-Coupled Receptor Kinase 3

A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response.


A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, isolated from rodents and lagomorphs and occasionally causing febrile illness in man.


Mice, Inbred CBA
Mouse, Inbred CBA
Mice, CBA
Mouse, CBA

An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH.


Self-Referral, Physician
Physician Self-Referral

Referral by physicians to testing or treatment facilities in which they have financial interest. The practice is regulated by the Ethics in Patient Referrals Act of 1989.


Pseudo-Cowpox Virus
Paravaccinia Virus
Milker's Nodes Virus
Milkers' Nodes Virus
Pseudocowpox Virus

A species of PARAPOXVIRUS causing a pox-like disease on udders of cows that may spread to milkers.


Surgical Procedures, Minor
Minor Surgical Procedures
Procedure, Minor Surgical
Surgery, Minor
Surgical Procedure, Minor
Minor Surgery
Procedures, Minor Surgical
Minor Surgical Procedure

Surgery for problems and injuries that are of relatively slight extent, and with a low risk for life threatening complications.


Plasmids which determine the ability of a bacterium to ferment lactose.


Acoustic Nerve
Cochlear Nerve
Auditory Nerve

The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.


Genetic Enhancements
Genetic Enhancement
Enhancement, Genetic
Enhancements, Genetic

The use of genetic methodologies to improve functional capacities of an organism rather than to treat disease.


A plant genus of the family FABACEAE that is the source of mucuna gum.


Polymicrogyria
Cerebral Micropolygyria
Micropolygyria
Cerebral Polymicrogyria

Heterogeneous disorders of cortical malformation characterized by excessive and small fused gyri and shallow sulci of the CORTEX with abnormal cortical lamination. It is considered a malformation secondary to abnormal post-migrational development of the neurons during cerebral cortical development and is associated with EPILEPSY and learning difficulties.


Staphylococcal Pneumonia
Pneumonia, Staphylococcal
Staphylococcus Aureus Pneumonia

Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.


delta-Crystallins
delta-Crystallin
Crystallins, delta

A subclass of crystallins found in the lens (LENS, CRYSTALLINE) in BIRDS and REPTILES. They are inactive forms of the enzyme argininosuccinate lyase.


A plant genus of the family BUXACEAE. Members contain steroidal alkaloids.


DNA Polymerase delta
DNA Pol III
DNA-Dependent DNA Polymerase III
DNA Polymerase III

A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.


A thin layer of cells forming the outer integument of seed plants and ferns. (Random House Unabridged Dictionary, 2d ed)


Research, Nursing Administration
Nursing Research, Administrative
Research, Administrative Nursing
Nursing Administration Research
Administration Research, Nursing
Administrative Nursing Research

Research concerned with establishing costs of nursing care, examining the relationships between nursing services and quality patient care, and viewing problems of nursing service delivery within the broader context of policy analysis and delivery of health services (from a national study, presented at the 1985 Council on Graduate Education for Administration in Nursing (CGEAN) meeting).


Myoclonus with Epilepsy with Ragged Red Fibers

Myoclonic Epilepsy with Ragged-Red Fibers

Myoencephalopathy Ragged-Red Fiber Disease

Myoclonic Epilepsy and Ragged Red Fibers

Myoclonic Epilepsy Associated with Ragged-Red Fibers

Myoclonic Epilepsy with Ragged Red Fibers

A mitochondrial encephalomyopathy characterized clinically by a mixed seizure disorder, myoclonus, progressive ataxia, spasticity, and a mild myopathy. Dysarthria, optic atrophy, growth retardation, deafness, and dementia may also occur. This condition tends to present in childhood and to be transmitted via maternal lineage. Muscle biopsies reveal ragged-red fibers and respiratory chain enzymatic defects. (From Adams et al., Principles of Neurology, 6th ed, p986)


Acrylaldehyde
2-Propenal
Acraldehyde
Ethylene Aldehyde
Acrylic Aldehyde
Aqualin
Allyl Aldehyde
Acrolein


5-HTP
Oxytryptophan
Oxitriptan
Hydroxytryptophan
Tryptophan, 5-Hydroxy-
5-Hydroxytryptophan

The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.


Photoreceptors, Invertebrate
Invertebrate Photoreceptors
Photoreceptor Cells, Invertebrate
Invertebrate Photoreceptor Cells

Specialized cells in the invertebrates that detect and transduce light. They are predominantly rhabdomeric with an array of photosensitive microvilli. Illumination depolarizes invertebrate photoreceptors by stimulating Na+ influx across the plasma membrane.


Bronchopulmonary Lavage
Lung Lavage
Bronchoalveolar Lavage
Bronchioalveolar Lavage
Lavage, Bronchopulmonary
Bronchial Lavage

Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.


Trematoda Flukes Paryphostomum Himasthla Troglotrema Echinochasmus

Class of parasitic flukes consisting of three subclasses, Monogenea, Aspidogastrea, and Digenea. The digenetic trematodes are the only ones found in man. They are endoparasites and require two hosts to complete their life cycle.


Bourneville's Disease
Phakomatosis, Bourneville
Sclerosis Tuberosa
Tuberous Sclerosis Complex
Bourneville Disease
Tuberous Sclerosis
Bourneville Phakomatosis
Epiloia
Tuberose Sclerosis
Bourneville-Pringle's Disease
Bourneville's Syndrome
Cerebral Sclerosis
Phacomatosis, Bourneville
Bourneville Syndrome
Adenoma Sebaceum
Bourneville-Pringle Disease

Facial ANGIOFIBROMA in tuberous sclerosis


The status or condition of a person over whom any or all of the powers attaching to the right of ownership are exercised. The slave trade is all acts involved in the capture, acquisition or disposal of persons with intent to reduce them to enslavement; all acts involved in the acquisition of enslaved persons with a view to selling or exchanging them; all acts of disposal by sale or exchange of persons acquired with a view to being sold or exchanged, and, in general, every act of trade or transport of slaves. (from http://www.ohchr.org/Documents/Publications/slaveryen.pdf accessed 10/18/2012)


Spleen Tyrosine Kinase
Syk Kinase
SYK Tyrosine Kinase

An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.


Evidence-Based Emergency Medicine
Emergency Medicine, Evidence-Based

A way of providing emergency medical care that is guided by a thoughtful integration of the best available scientific knowledge with clinical expertise in EMERGENCY MEDICINE. This approach allows the practitioner to critically assess research data, clinical guidelines, and other information resources in order to correctly identify the clinical problem, apply the most high-quality intervention, and re-evaluate the outcome for future improvement.


Ethoxycoumarin Deethylase
Cytochrome P-450-Dependent O-Dealkylase
7-Ethoxycoumarin Monooxygenase
7-Ethoxycoumarin O-Dealkylase
Ethoxycoumarin O-Deethylase
7-Propoxycoumarin O-Depropylase
7-Ethoxycoumarin O-De-Ethylase
7-Ethoxycoumarin Hydroxylase
7-Alkoxycoumarin O-Dealkylase
7-Ethoxycoumarin O-Deethylase
7-Ethoxycoumarin Dealkylase

A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.


Guama virus
Orthobunyavirus
Apeu virus
Catu virus
Bunyavirus

A genus of the family BUNYAVIRIDAE containing over 150 viruses, most of which are transmitted by mosquitoes or flies. They are arranged in groups defined by serological criteria, each now named for the original reference species (previously called serogroups). Many species have multiple serotypes or strains.


Serine Carboxypeptidase I
BGPP
Carboxypeptidase C
Cathepsin A
Carboxypeptidase Y
beta-Galactosidase Protective Protein
Endothelin Degradation Enzyme
Lysosomal Protective Protein
Acid Carboxypeptidase

A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. It also plays a role in the LYSOSOMES by protecting BETA-GALACTOSIDASE and NEURAMINIDASE from degradation. It was formerly classified as EC 3.4.12.1 and EC 3.4.21.13.


CDw52 Antigen
HLA-Bw52 Antigen
Cambridge Pathology 1 Antigen
Lymphocyte Antigen CD52
CD52 Protein
Lymphocyte Antigen CDw52
HLA-Bw52
Campath-1 Antigen
Campath-1 Receptor
Campath-1H Antigen
CD52 Antigen

A small GPI-linked glycoprotein expressed on the surface of normal and malignant B-CELLS; T-CELLS; MONOCYTES; MACROPHAGES; NK CELLS; and GRANULOCYTES. It is expressed densely and without modulation in many malignant T-cell neoplasms and therefore a target for antibody therapies (e.g., ALEMTUZUMAB).


Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)


Thymus and Activation-Regulated Chemokine

A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.


A condition of low alertness or cognitive impairment, usually associated with prolonged mental activities or stress.


A non-hydrolyzed muscarinic agonist used as a research tool.


Echo Virus 6
Echovirus 6
Human echovirus 6
Burgess Virus
Echovirus 6, Human

A species of ENTEROVIRUS that has caused outbreaks of aseptic meningitis in children and adults.


alpha-Factor (Fungal)
Pheromone a-Factor
Mating Factor
alpha-Agglutinin (Fungal)
Mating Hormone
Sexual Agglutination Factor
Pheromone alpha-Factor
alpha-Mating Factor

A protein also known as pheromone mating factor that occurs on the surfaces of organisms such as yeast and fungi.


Major Histocompatibility Complex
Histocompatibility Complex

The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.


Enzootic Pneumonia of Swine
Mycoplasma Pneumonia of Swine
Enzootic Pneumonia of Pigs
Pneumonia of Swine, Enzootic
Mycoplasma Pneumonia of Pigs
Pneumonia of Swine, Mycoplasmal
Mycoplasmal Pneumonia of Swine

A chronic, clinically mild, infectious pneumonia of PIGS caused by MYCOPLASMA HYOPNEUMONIAE. Ninety percent of swine herds worldwide are infected with this economically costly disease that primarily affects animals aged two to six months old. The disease can be associated with porcine respiratory disease complex. PASTEURELLA MULTOCIDA is often found as a secondary infection.


The minimum acceptable patient care, based on statutes, court decisions, policies, or professional guidelines.


Maxillofacial Injuries
Injuries, Maxillofacial

General or unspecified injuries involving the face and jaw (either upper, lower, or both).


Leukemia, B-Cell
Leukemia, Lymphocytic, B Cell
B-Cell Leukemia
B-Lymphocytic Leukemia
Leukemia, Lymphocytic, B-Cell
Lymphocytic Leukemia, B-Cell

A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.


Alcohol Oxidoreductases
Ketone Reductases
Carbonyl Reductases

A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).


A genus of gram-positive, facultatively anaerobic bacteria whose growth is dependent on the presence of a fermentable carbohydrate. It is nonpathogenic to plants and animals, including humans.


Hernia, Inguinal
Inguinal Hernia
Inguinal Hernia, Indirect
Inguinal Hernia, Direct

An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.


Blood Cell Count
Blood Count, Complete
Blood Cell Number

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.


Cloud Service
Cloud Computing
Cloud Processing
Cloud Storage

Storing and processing data on multiple servers that can be accessed through the Internet.


Reflex, Pharyngeal
Pharyngeal Reflex
Gagging

Contraction of the muscle of the PHARYNX caused by stimulation of sensory receptors on the SOFT PALATE, by psychic stimuli, or systemically by drugs.


Hypertension, Pulmonary
Pulmonary Hypertension

Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.


Viaflex
Chloroethylene Homopolymer
Vinylite
Chloroethylene Polymer
Polyvinyl Chloride
Geon
Ultron
PVC
Polychloroethylene
Vinyl Chloride Polymer

A polyvinyl resin used extensively in the manufacture of plastics, including medical devices, tubing, and other packaging. It is also used as a rubber substitute.


Ethylene Polymers
Polyethylenes
Ethene Homopolymers

Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.


A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.


Infections, Astroviridae
Astroviridae Infections

Infections with ASTROVIRIDAE, causing gastroenteritis in human infants, calves, lambs, and piglets.


HPV Infection
Papillomavirus Infections
Human Papillomavirus Infection

Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.


Programmed Cell Death 1 Ligand 1 Protein

An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. It has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN and provides negative signals that control and inhibit T-cell responses. It is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.


Vestibulocochlear Apparatus
Ear
Vestibulocochlear System

The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.


rasGEF
ras-GEFs
ras Guanine Nucleotide Exchange Factor
rasGEFs
ras Guanine Nucleotide Exchange Factors
ras-GEF

A family of GUANINE NUCLEOTIDE EXCHANGE FACTORS that are specific for RAS PROTEINS.


Intensive Care Units, Pediatric
Pediatric Intensive Care Units

Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.


Gibraltar Fever
Malta Fever
Cyprus Fever
Brucellosis, Pulmonary
Undulant Fever
Brucella Infection
Rock Fever
Brucellosis

Human BRUCELLA infection with pulmonary involvement such as EMPYEMA; LUNG ABSCESS; and PLEURAL EFFUSION.


Disinfectants, Dental
Dental Disinfectants

Chemicals especially for use on instruments to destroy pathogenic organisms. (Boucher, Clinical Dental Terminology, 4th ed)


Salsola
Tumbleweed
Saltwort
Thistle, Russian

A plant genus of the family CHENOPODIACEAE. The extract may be called lochein. Tumbleweed may occasionally refer to AMARANTHUS.


Bilateral Vestibulopathy
Bilateral Vestibular Loss
Vestibular Areflexia
Bilateral Vestibular Deficiency
Bilateral Vestibular Insufficiency

Impairment of the vestibular function of both inner ears which can cause difficulties with balance, gait, VERTIGO, and visual blurring.


Prussian Blue Reaction
Ferrocyanide Reaction

The reaction of potassium ferrocyanide with ferric iron to yield a dark blue precipitate at the sites of the ferric iron. Used to determine ferric iron in tissues, particularly in the diagnosis of disorders of iron metabolism.


Pseudomonas Infections
Pseudomonas aeruginosa Infection
Infections, Pseudomonas

Infections with bacteria of the genus PSEUDOMONAS.


Thromboxane A Synthase
Thromboxane A2 Synthetase
Thromboxane Synthetase
Thromboxane-A Synthase

An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane A2. EC 5.3.99.5.


Stefin B
Cystatin B
Liver Thiol Proteinase Inhibitor

An intracellular cystatin subtype that is found in a broad variety of cell types. It is a cytosolic enzyme inhibitor that protects the cell against the proteolytic action of lysosomal enzymes such as CATHEPSINS.


Diffusion Magnetic Resonance Imaging
Diffusion Weighted MRI
Magnetic Resonance Imaging, Diffusion
Diffusion MRI

A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.


Acetoacetyl CoA Thiolase
Acetyl-CoA C-Acetyltransferase
Acetyl Coenzyme A Acetyltransferase
Acetyl-CoA Acetyltransferase

An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred to this activity or to the activity of ACETYL-COA C-ACYLTRANSFERASE.


Monoester Lipase
Triacylglycerol Lipase
Lipase
Exolipase
Acid Lipase II
Acid Lipase B
Triglyceridase
Acid Lipase I
Triglyceride Lipase
Tributyrinase
Triacylglycerol Hydrolase
Acid Lipase
Acid Lipase A
Triolean Hydrolase

An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.


Life-Breath (Philosophy)
Vital Energy (Philosophy)
Ch'i
Qi

The vital life force in the body, supposedly able to be regulated by acupuncture. It corresponds roughly to the Greek pneuma, the Latin spiritus, and the ancient Indian prana. The concept of life-breath or vital energy was formulated as an indication of the awareness of man, originally directed externally toward nature or society but later turned inward to the self or life within. (From Comparison between Concepts of Life-Breath in East and West, 15th International Symposium on the Comparative History of Medicine - East and West, August 26-September 3, 1990, Shizuoka, Japan, pp. ix-x)


6-Phosphofructokinase, Liver Type
Phosphofructo-1-kinase Isozyme B
Phosphofructokinase-1, Liver Type

An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In human liver, the 6-phosphofructose-1-kinase exists as the homotetramer of L subunits.


Escherichia coli Infections
Infections, Escherichia coli
Infections, E coli
E. coli Infection
E coli Infections

Infections with bacteria of the species ESCHERICHIA COLI.


Nonsteroidal Anti-Androgens
Nonsteroidal Antiandrogens
AntiAndrogens, Nonsteroidal

Nonsteroidal agents which block the action or downregulate the synthesis of ANDROGENS.


Prunus africana
Pygeum africanum
Prune, African
African Prune

A plant species in the family ROSACEAE. The bark extract known as pygeum is an ingredient in FOLK REMEDIES.


Mobilization of the lower end of the esophagus and plication of the fundus of the stomach around it (fundic wrapping) in the treatment of GASTROESOPHAGEAL REFLUX that may be associated with various disorders, such as hiatal hernia. (From Dorland, 28th ed)


Polyneuropathy, Paraneoplastic
Paraneoplastic Polyneuropathy
Peripheral Neuropathy, Paraneoplastic
Paraneoplastic Peripheral Neuropathy
Paraneoplastic Neuropathy
Neuropathy, Paraneoplastic

A diffuse or multifocal peripheral neuropathy related to the remote effects of a neoplasm, most often carcinoma or lymphoma. Pathologically, there are inflammatory changes in peripheral nerves. The most common clinical presentation is a symmetric distal mixed sensorimotor polyneuropathy. (Adams et al., Principles of Neurology, 6th ed, p1334)


Newborn ICU
Neonatal ICU
Intensive Care Units, Neonatal
ICU, Neonatal
Neonatal Intensive Care Units
Newborn Intensive Care Units
Newborn Intensive Care Units (NICU)

Hospital units providing continuing surveillance and care to acutely ill newborn infants.


Sinoatrial Arrhythmia
Arrhythmia, Sinoatrial
Sinus Arrhythmia
Arrhythmia, Sinus

Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.


Digitoxin Monoacetate
Acetyldigitoxin
Desglucolanatosides A
Acedoxin
alpha-Acetyldigitoxin
Acetyldigitoxins
Adicin

Cardioactive derivatives of lanatoside A or of DIGITOXIN. They are used for fast digitalization in congestive heart failure.


Ethylene Chlorohydrin
2-Chlorethanol
Ethylenechlorhydrin
2-Chloroethyl Alcohol

Used as a solvent, in the manufacture of insecticides, and for treating sweet potatoes before planting. May cause nausea, vomiting, pains in head and chest, stupefaction. Irritates mucous membranes and causes kidney and liver degeneration.


Glucose-6-Phosphatase
Glucose-6-Phosphate Phosphohydrolase
Glucosephosphatase
Glucose 6-Phosphatase

An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9.


TIE Receptor Family
Receptor Tyrosine Kinase TIE
TIE Receptor Tyrosine Kinase
TIE Receptor Tyrosine Kinases
Receptors, TIE

A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.


1-Chloro-2,4-Dinitrobenzene DNCB Chlorodinitrobenzene Dinitrochlorobenzene

A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.


Worthless, damaged, defective, superfluous or effluent material from industrial operations.


Nasal Deformities, Acquired
Nose Deformities, Acquired
Acquired Nasal Deformities

Abnormalities of the nose acquired after birth from injury or disease.


Iodized Oils
Iodized Oil
Oil, Iodized
Iodolipol

A preparation of oil that contains covalently bound IODINE. It is commonly used as a RADIOCONTRAST AGENT and as a suspension medium for CHEMOTHERAPEUTIC AGENTS.


An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.


IL4 Receptors
IL-4 Receptor
IL4 Receptor
Receptors, IL-4
IL-4 Receptors
Interleukin 4 Receptor
Receptors, Interleukin-4
Interleukin-4 Receptors

Receptors present on a wide variety of hematopoietic and non-hematopoietic cell types that are specific for INTERLEUKIN-4. They are involved in signaling a variety of immunological responses related to allergic INFLAMMATION including the differentiation of TH2 CELLS and the regulation of IMMUNOGLOBULIN E production. Two subtypes of receptors exist and are referred to as the TYPE I INTERLEUKIN-4 RECEPTOR and the TYPE II INTERLEUKIN-4 RECEPTOR. Each receptor subtype is defined by its unique subunit composition.


SAPAP Protein
SAP90-PSD95 Associated Proteins
SAP90-PSD-95-Associated Proteins
SAPAP Proteins

Proteins expressed at SYNAPSES throughout the brain where they interact with different scaffolding proteins, cytoskeletal proteins, and signaling factors to assemble functional multiprotein complexes.


An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.


CREM Protein, alpha Isoform
CREM Protein, tau Isoform
Inducible cAMP Early Regulator
Cyclic AMP Response Element Modulator
CREM Protein, epsilon Isoform
ICERIIgamma
ICERIgamma
CREM Protein, gamma Isoform
cAMP-Responsive Element Modulator

Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.


Ectopic Atrial Tachycardia
Atrial Ectopic Tachycardia
Tachycardia, Ectopic Atrial

Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.


Acoustic Rhinometry
Rhinometry, Acoustic

Diagnostic measurement of the nose and its cavity through acoustic reflections. Used to measure nasal anatomical landmarks, nasal septal deviation, and nasal airway changes in response to allergen provocation tests (NASAL PROVOCATION TESTS).


Transmissible Enteritis Virus of Turkeys

A species of CORONAVIRUS causing enteritis in turkeys and pullets.


Sixth Disease
Exanthema Subitum
Roseola Infantum

An acute, short-lived, viral disease of infants and young children characterized by a high fever at onset that drops to normal after 3-4 days and the concomitant appearance of a macular or maculopapular rash that appears first on the trunk and then spreads to other areas. It is the sixth of the classical exanthematous diseases and is caused by HHV-6; (HERPESVIRUS 6, HUMAN). (From Dorland, 27th ed)


Inflammation and infection of the lacrimal canaliculus area in the LACRIMAL APPARATUS.


Lycopus
Bugleweed
Lycopus virginicus
Horehound, Water

A plant genus of the family LAMIACEAE that contains rosmarinic acid and isopimarane diterpenoids and has been used in folk medicine for HYPERTHYROIDISM.


Mitogen-Activated Protein Kinase Kinase 1

An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.


Pharmacologic agents delivered into the nostrils in the form of a mist or spray.


Surgical fixation of the stomach to the abdominal wall.


Dental Pulp Diseases
Disease, Dental Pulp
Dental Pulp Disease
Diseases, Dental Pulp
Pulp Diseases, Dental
Pulp Disease, Dental

Endodontic diseases of the DENTAL PULP inside the tooth, which is distinguished from PERIAPICAL DISEASES of the tissue surrounding the root.


A plant genus of the family FABACEAE. Members contain wistarin, wisteria lectin and wistariasaponin.


IAP-50 Antigen
CD47 Antigen
Integrin-Associated Protein p50
Thrombospondin-1 Receptor CD47
CD47 Antigens
Antigens, CD47

A ubiquitously expressed membrane glycoprotein. It interacts with a variety of INTEGRINS and mediates responses to EXTRACELLULAR MATRIX PROTEINS.


Stromelysin 2
MMP10 Metalloproteinase
MMP-10 Metalloproteinase
Matrix Metalloproteinase 10

A secreted matrix metalloproteinase that may play a role in matrix degradation during WOUND HEALING. It is expressed at high levels by KERATINOCYTES, suggesting its role in keratinocyte migration.


Prolactinoma, Familial
Prolactin-Producing Pituitary Adenoma
Lactotroph Adenoma
PRL-Secreting Pituitary Adenoma
Adenoma, Prolactin-Secreting, Pituitary
Microprolactinoma
Macroprolactinoma
Prolactin-Secreting Pituitary Adenoma
Pituitary Adenoma, Prolactin-Secreting
Prolactinoma

A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.


A plant genus of the family BORAGINACEAE. Members contain TRITERPENES and naphthoxirene.


Biopropazepan Trimethoxybenzoate
Dilazep
Cormelian
Asta C 4898

Coronary vasodilator with some antiarrhythmic activity.


Care, Primary Nursing
Primary Nursing
Primary Nursing Care
Nursing Care, Primary

The primary responsibility of one nurse for the planning, evaluation, and care of a patient throughout the course of illness, convalescence, and recovery.


Skin Bleaching Agents
Depigmenting Agents
Skin Lightening Preparations
Skin Depigmenting Agents
Skin Whitening Agents

Substances used to obtain a lighter skin complexion or to treat HYPERPIGMENTATION disorders.


Summer cypress
Firebrush
Burningbush (Bassia)
Bassia scoparia
Fireweed
Kochia scoparia

A plant species of the family CHENOPODIACEAE. It is a source of furonaphthoquinones. The common name of burning bush is also used with the unrelated EUONYMUS sieboldianus.


Hydrocephalus, Noncommunicating, Dandy-Walker Type

Hydrocephalus, Internal, Dandy-Walker Type

A congenital abnormality of the central nervous system marked by failure of the midline structures of the cerebellum to develop, dilation of the fourth ventricle, and upward displacement of the transverse sinuses, tentorium, and torcula. Clinical features include occipital bossing, progressive head enlargement, bulging of anterior fontanelle, papilledema, ataxia, gait disturbances, nystagmus, and intellectual compromise. (From Menkes, Textbook of Child Neurology, 5th ed, pp294-5)


A component of the CYTOCHROME B6F COMPLEX, this enzyme catalyzes the oxidation of plastoquinol-1 to PLASTOQUINONE.


Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.


A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.


Lymphoid Progenitor Cells
Common Lymphoid Progenitors
Stem Cells, Lymphoid

Stem cells from which B-LYMPHOCYTES; T-LYMPHOCYTES; NATURAL KILLER CELLS; and some DENDRITIC CELLS derive.


Clostridium sordelli
Clostridium sordellii

A species of gram-positive bacteria in the family Clostridiaceae, found in INTESTINES and SOIL.


WAP Four-Disulfide Core Domain Protein 2

A secreted 25-kDa glycoprotein member of the Whey-acidic-protein (WAP) four-disulfide core (WFDC) domain family with tissue specific expression in the EPIDIDYMIS. It is also expressed in a limited number of other organs which include female reproductive tract, breast tissue, kidney, regions of the respiratory tract and nasopharynx. The protein is a biomarker for epithelial ovarian cancer.


Valosine-Containing Protein
Valosin Containing Protein
p97 Valosin-Containing Protein
CDC48 Protein
Valosin-Containing Protein
Cell Cycle Protein CDC48p
Cell Cycle Protein CDC48

A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.


Gram-Negative Facultatively Anaerobic Rods

Gram Negative Facultatively Anaerobic Rods

A large group of facultatively anaerobic, rod-shaped bacteria that show up as pink (negative) when treated by the gram-staining method.


Endographin Iodipamide Bilipolinum Endocistobil Bilignost Biligrafine Cholografin Adipiodon

A water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.


A multifunctional cytokine secreted by primarily by activated TH2 CELLS that may play a role as a regulator of allergic INFLAMMATION. It has been shown to enhance the growth and CELL DIFFERENTIATION of MAST CELLS, and can act on a variety of other immune cells.


The condition in which individuals are financially unable to access adequate medical care without depriving themselves and their dependents of food, clothing, shelter, and other essentials of living.


TP73 Protein
Tumor Protein p73
Protein p73
p73 Protein
p73-alpha
Tumor Suppressor Protein p73
p73-beta
Tap73 Protein, Human

A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice variants and isoforms in the nervous system (human TELENCEPHALON, CHOROID PLEXUS; CEREBROSPINAL FLUID), embryonic tissue, human BREAST CANCER; OVARIAN CANCER, suggest roles in cellular differentiation.


Salts and esters of the 12-carbon saturated monocarboxylic acid--lauric acid.


Removable prosthesis constructed over natural teeth or implanted studs.


Paralysis, Obstetrical
Paralysis, Obstetric

Paralysis of an infant resulting from injury received at birth. (From Dorland, 27th ed)


Private, Investor-Owned Hospitals
Hospitals, Private, Investor-Owned
Hospitals, Proprietary
Private, for-Profit Hospitals
Hospitals, Private, for-Profit
Proprietary Hospitals

Hospitals owned and operated by a corporation or an individual that operate on a for-profit basis, also referred to as investor-owned hospitals.


Nailfold Capillaroscopy
Videocapillaroscopy
Capillaroscopy
Microscopic Angioscopy

The noninvasive microscopic examination of the microcirculation, commonly done in the nailbed or conjunctiva. In addition to the capillaries themselves, observations can be made of passing blood cells or intravenously injected substances. This is not the same as endoscopic examination of blood vessels (ANGIOSCOPY).


Afghan War, 2001-
Afghan Campaign 2001-
Operation Enduring Freedom

Multinational coalition military operation initiated in October 2001 to counter terrorism and bring security to AFGHANISTAN in collaboration with Afghan forces.


An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.


Expanded Trinucleotide Repeat
Trinucleotide Repeat Expansion

An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.


A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.


Heparan Sulfate Proteoglycan Core Protein

A syndecan that is predominantly expressed during EMBRYONIC DEVELOPMENT. It may play a role in mediating cellular interactions with the EXTRACELLULAR MATRIX and may modulate the signaling activity of certain INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.


Immunoglobulin Joining Region Peptide Fragments

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.


A forkhead box transcription factor that is expressed primarily in adult organs which contain proliferating cells such as the thymus, testis, ovary, and small intestine. It controls the expression of CELL CYCLE genes essential for DNA REPLICATION and MITOSIS, and also functions in DNA REPAIR.


Multicellular marine macroalgae including some members of red (RHODOPHYTA), green (CHLOROPHYTA), and brown (PHAEOPHYTA) algae. They are widely distributed in the ocean, occurring from the tide level to considerable depths, free-floating (planktonic) or anchored to the substratum (benthic). They lack a specialized vascular system but take up fluids, nutrients, and gases directly from the water. They contain CHLOROPHYLL and are photosynthetic, but some also contain other light-absorbing pigments. Many are of economic importance as FOOD, fertilizer, AGAR, potash, or source of IODINE.