Estramustinphosphate
Estracyt
Emcyt
Estramustine Phosphate Sodium
NSC-89199
Estramustin Phosphate
Estramustine
Leo-275

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.


Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Epilepsy With Centrotemporal Spikes

Benign Childhood Epilepsy With Centro-Temporal Spikes

An autosomal dominant inherited partial epilepsy syndrome with onset between age 3 and 13 years. Seizures are characterized by PARESTHESIA and tonic or clonic activity of the lower face associated with drooling and DYSARTHRIA. In most cases, affected children are neurologically and developmentally normal. (From Epilepsia 1998 39;Suppl 4:S32-S41)


Heterograft Bioprosthesis
Bioprosthesis
Xenograft Bioprosthesis
Porcine Xenograft Bioprosthesis
Glutaraldehyde-Stabilized Grafts

Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. Durability is achieved 1, mechanically by the interposition of a cloth, usually polytetrafluoroethylene, between the host and the graft, and 2, chemically by stabilization of the tissue by intermolecular linking, usually with glutaraldehyde, after removal of antigenic components, or the use of reconstituted and restructured biopolymers.


Prausnitz-Kustner Test
Passive Transfer Test
Intradermal Tests

Skin tests in which the sensitizer is injected.


A type II keratin found associated with KERATIN-16 or KERATIN-17 in rapidly proliferating squamous epithelial tissue. Mutations in gene for keratin-6A and keratin-6B have been associated with PACHYONYCHIA CONGENITA, TYPE 1 and PACHYONYCHIA CONGENITA, TYPE 2 respectively.


Endpoint Determination
End Point Determination
End Point Assay
Endpoint Assay

Establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect.


Phospholipase A2, Group IVD
Group IVF Phospholipases A2
Group IVD Phospholipase A2
Phospholipase A2-gamma
Phospholipase A2, Group IVE
Group IV Cytosolic Phospholipase A2
Group IVE Phospholipases A2
Cytosolic Phospholipase A2 beta
Cytosolic Phospholipase A2 epsilon
Cytosolic Phospholipase A2 gamma
Group IVA Phospholipase A2
cPLA2-alpha
Phospholipase A2, Group IVF
PLA2-IV
Group IV Phospholipases A2
Group IVC Phospholipase A2
Phospholipase A2 Group IVA
Phospholipase A(2)alpha
Group IVB Phospholipases A2
Group IVB Phospholipase A2
Group IVC Phospholipases A2
Cytosolic Phospholipase A2 alpha
Group IVE Phospholipase A2
Cytosolic Phospholipase A2 delta
Phospholipase A2-alpha
Phospholipase A2, Group IVB
Phospholipase A2-beta
cPLA2-gamma
PLA(2)-IV
Phospholipase A2 IV
Phospholipase A2, Group IVC
Group IVF Phospholipase A2
Phospholipases A2, Group IV
Group IVD Phospholipases A2
Group IVA Phospholipases A2

A cytosolic phospholipase A2 group that plays an important role in the release of free ARACHIDONIC ACID, which in turn is metabolized to PROSTAGLANDINS by the CYCLOOXYGENASE pathway and to LEUKOTRIENES by the 5-LIPOXYGENASE pathway.


Cytarabine Hydrochloride
Aracytine
beta-Ara C
Cytosar-U
Ara-C
Cytosine Arabinoside
Arabinofuranosylcytosine
Cytarabine
Aracytidine
Cytonal
Cytosar
Arabinosylcytosine

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)


Petromyzon marinus
Sea Lamprey
Petromyzon

A genus of primitive fish in the family Petromyzontidae. The sole species is Petromyzon marinus, known as the sea lamprey. The adult form feeds parasitically on other fish species.


Genealogical Tree
Genealogic Tree
Identity, Genetic
Pedigree
Family Tree
Genetic Identity

The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.


Anemia, Dyserythropoietic Congenital, Type III

Dyserythropoietic Anemia, Congenital Type 2

Type I Congenital Dyserythropoietic Anemia

Anemia With Multinucleated Erythroblasts

Congenital Dyserythropoietic Anemia Type 1

Anemia, Dyserythropoietic, Congenital Type 1

Congenital Dyserythropoietic Anemia Type II

Anemia, Congenital Dyserythropoietic, Type II

Congenital Dyserythropoietic Anemia, Type III

Dyserythropoietic Anemia, Congenital Type 1

Anemia, Dyserythropoietic, Congenital, Type III

Hereditary Erythroblastic Multinuclearity with Positive Acidified-Serum Test

Dyserythropoietic Anemia, Congenital, Type III

Anemia, Dyserythropoietic, Congenital Type 2

A familial disorder characterized by ANEMIA with multinuclear ERYTHROBLASTS, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (ERYTHROID PRECURSOR CELLS). Type II is the most common of the 3 types; it is often referred to as HEMPAS, based on the Hereditary Erythroblast Multinuclearity with Positive Acidified Serum test.


Carteolol Monohydrochloride
Carteolol Hydrochloride
Carteolol
OPC-1085

A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.


Plastid Proteins
Chloroplast Proteins
Chloroplast Genome-Encoded Proteins
Chloroplast Encoded Proteins

Proteins encoded by the CHLOROPLAST GENOME or proteins encoded by the nuclear genome that are imported to and resident in the CHOROPLASTS.


Bethanidine Sulfate
Bethanidine
Bethanidine, Sulfate (2:1)
Betanidine
Batel

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.


Teeth, Fused
Fused Teeth
Incisors, Fused Mandibular
Fused Mandibular Incisors
Double Tooth

Two teeth united during development by the union of their tooth germs; the teeth may be joined by the enamel of their crowns, by their root dentin, or by both.


Phosphoinositide phosphatases that catalyze the removal of the 5' phosphate from INOSITOL 1,4,5-TRISPHOSPHATE  or myo-inositol 1,3,4,5-tetrakisphosphate, resulting in inositol 1,4-bisphosphate and phosphate. They have important functions in the metabolism of INOSITOL PHOSPHATES and inositol 1,4,5-trisphosphate signaling pathways such as CALCIUM SIGNALING.


Collagen Type XII, alpha1 Subunit
Collagen Type XII, alpha1 Chain
Type XII Procollagen
Collagen alpha1(XII)
Type XII Collagen
Collagen Type XII
Procollagen Type XII

A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.


Biomodulators
Immunologic Factors
Response Modifiers, Biological
Modifiers, Biological Response
Biological Response Modifiers
Immunomodulators
Immunological Factors
Immune Factors
Factors, Immunologic

Biologically active substances whose activities affect or play a role in the functioning of the immune system.


Ritodrine Hydrochloride
Pre-Par
Yutopar
Ritodrine
DU-21220

An adrenergic beta-2 agonist used to control PREMATURE LABOR.


Macular Dystrophy With Flecks, Type 1
Stargardt Macular Degeneration
Juvenile Macular Degeneration
Stargardt Disease 1
Macular Degeneration, Juvenile
Fundus Flavimaculatus
Stargardt Disease

A juvenile-onset macular dystrophy characterized by progressive loss of VISUAL ACUITY with normal acuity in peripheral VISUAL FIELDS. Other associated clinical features may include LIPOFUSCIN fundus autofluorescence, atrophy of the RETINAL PIGMENT EPITHELIUM, loss of color vision, PHOTOPHOBIA and PARACENTRAL SCOTOMA. Germline mutations in the ABCA4 gene have been identified in recessive and dominant diseases.


Cancer of the Mouth
Cancer of Mouth
Mouth Neoplasms
Neoplasms, Oral
Oral Neoplasms
Mouth Cancer
Neoplasms, Mouth
Oral Cancer


Photorhabdus luminescens
Xenorhabdus luminescens
Photorhabdus

A genus of gram-negative bacteria existing symbiotically with nematodes of the family Heterorhabditidae (see RHABDITOIDEA). These nematodes infect a variety of soil-dwelling insects. Upon entering an insect host, the nematode releases Photorhabdus from its intestinal tract and the bacterium establishes a lethal septicemia in the insect.


Teschovirus
Teschen Disease Virus
Porcine teschovirus
Talfan Disease Virus

A genus in the family PICORNAVIRIDAE that can cause polioencephalomyelitis in pigs. The type species Porcine teschovirus is comprised of multiple strains.


Gastrointestinal Endoscopic Surgical Procedures

Procedures, Gastrointestinal Endoscopic Surgical

Procedure, Gastrointestinal Endoscopic Surgical

Procedures, Endoscopic Gastrointestinal, Surgical

Surgical Procedures, Endoscopic Gastrointestinal

Surgical Procedure, Endoscopic Gastrointestinal

Endoscopic Gastrointestinal Surgical Procedures

Procedure, Endoscopic Gastrointestinal, Surgical

Endoscopic examination, therapy or surgery of the gastrointestinal tract.


Uroporphyrinogen III Synthase, Deficiency of

Deficiency of Uroporphyrinogen III Synthase

An autosomal recessive porphyria that is due to a deficiency of UROPORPHYRINOGEN III SYNTHASE in the BONE MARROW; also known as congenital erythropoietic porphyria. This disease is characterized by SPLENOMEGALY; ANEMIA; photosensitivity; cutaneous lesions; accumulation of hydroxymethylbilane; and increased excretion of UROPORPHYRINS and COPROPORPHYRINS.


Investigator, Clinical
Clinical Investigator
Survey Personnel
Research Personnel
Researchers
Investigators, Clinical
Investigators
Clinical Investigators


Feral Pigeons
Rock Doves
Pigeons
Columba livia
Columbidae
Domestic Pigeons
Doves
Rock Pigeons

Family in the order COLUMBIFORMES, comprised of pigeons or doves. They are BIRDS with short legs, stout bodies, small heads, and slender bills. Some sources call the smaller species doves and the larger pigeons, but the names are interchangeable.


Majorana hortensis
Origanum
Origanum majorana
Oregano Plant
Sweet Marjoram
Marjoram
Marjoram Plant
Origanum vulgare
Oregano
Origanum onites

A plant genus of the family Lamiaceae that is the source of familiar seasonings, oregano and marjoram.


Deficient DNA Repair
DNA Repair-Deficiency Disorders
Chromosome Instability Syndromes
DNA Repair-Deficiency

Disorders resulting from defective DNA REPAIR processes or the associated cellular responses to DNA DAMAGE.


Topical Anti-Infective Agents
Microbicides, Topical
Local Anti-Infective Agents
Microbicides, Local
Antiinfective Agents, Topical
Antiseptics
Local Antiinfective Agents
Anti-Infective Agents, Local
Anti-Infective Agents, Topical
Antiinfective Agents, Local
Topical Antiinfective Agents

Generically, any topical agent that destroys microbes. However, usage of the term is increasingly being confined to topical agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES.


Dislocation, Tooth
Tooth Luxation
Avulsed Tooth
Tooth Avulsion

Partial or complete displacement of a tooth from its alveolar support. It is commonly the result of trauma. (From Boucher's Clinical Dental Terminology, 4th ed, p312)


Transcriptome
Transcriptomes
Gene Expression Signatures
Transcriptome Profiles
Gene Expression Profiles

The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.


Methanococcus jannaschii
Methanocaldococcus vulcanius
Methanocaldococcus
Methanocaldococcus indicus
Methanocaldococcus jannaschii
Methanocaldococcus infernus
Methanocaldococcus fervens

A genus of obligate anaerobic METHANOCALDOCOCCACEAE whose organisms are non-motile despite possessing long thin flagella. These methanogens are found in deep-sea vent and other hydrothermal environments.


Tolmetin Sodium, Dihydrate
Tolmetin Sodium Anhydrous
Tolmetin Sodium, Anhydrous
Tolectin
Tolmetin
McN-2559
Tolmetin Sodium

A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.


Calcium-Calmodulin-Dependent Protein Kinases, Restricted

Restricted Calcium-Calmodulin-Dependent Protein Kinases

Calcium-Calmodulin-Dependent Protein Kinases, Multifunctional

Multifunctional Calcium-Calmodulin-Dependent Protein Kinases

A subclass of calcium-calmodulin-dependent protein kinases that have broad substrate specificity.


Dromaiidae
Emu
Emus
Dromaius novaehollandiae

A family of flightless, running BIRDS, in the order Casuariiformes. The emu is the only surviving member of the family. They naturally inhabit forests, open plains, and grasslands in Australia.


Adrenoleukodystrophy, Autosomal, Neonatal Form

Adrenoleukodystrophy, Autosomal Neonatal Form

A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.


Sequence Homology, Protein
Homologs, Protein Sequence
Homology, Protein Sequence
Sequence Homology, Amino Acid
Homologous Sequences, Amino Acid
Amino Acid Sequence Homology
Protein Sequence Homologs
Protein Sequence Homology
Homologs, Amino Acid Sequence

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.


Acute Idiopathic Blind Spot Enlargement Syndrome

Acute Posterior Multifocal Placoid Pigment Epitheliopathy

A group of idiopathic multifocal posterior uveitis syndromes involving the CHOROID; RETINAL PIGMENT EPITHELIUM; and RETINA. They are characterized by multiple lesions of hypoautofluorescent dots in the FUNDUS OCULI and reduced VISUAL ACUITY. Several entities including BIRDSHOT CHORIORETINOPATHY are HLA-A ANTIGENS serotype A29 positive.


Electrophysiologic Concepts
Electrophysiological Concepts
Electrophysiological Process
Electrophysiological Phenomena
Electrophysiological Processes
Electrophysiological Phenomenon
Electrophysiologic Phenomena

The electrical properties, characteristics of living organisms, and the processes of organisms or their parts that are involved in generating and responding to electricity.


Inflammatory Encephalomyelitis
Encephalomyelitis, Inflammatory
Encephalomyelitis
Myeloencephalitis

A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.


A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.


Genes, Dominant
Dominant Genetic Conditions
Conditions, Dominant Genetic
Genetic Conditions, Dominant

Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.


YM-09330
Cefotan
Cefotetan Disodium Salt
Apatef
Apacef
Cefotetan
Cefotetan Disodium
Ceftotan
ICI-156834

A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.


Immunoconjugate
Radioimmunoconjugate
Radioimmunoconjugates
Immunoconjugates
Antibody-Drug Conjugates

Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.


Jod beta
Jodetten Henning
Potassium Iodide
Ioduro Potasico Rovi
Thyroprotect
Mono-Jod
Jodid Hexal
Antistrumin
Pima
Jodid dura
Jodid-ratiopharm
Iosat
Jodid Verla
SSKI
Jodid
Jodgamma
Thyro-Block

An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)


Raphe Pontis
Nucleus Raphe Magnus
Nucleus Raphes Magnus
Nuclei Raphe Magnus
Nucleus Raphe Pontis
Pontine Raphe Nucleus
Raphe Pontis Nucleus
Raphe Magnus Nucleus

A nucleus located directly rostral to the NUCLEUS RAPHE OBSCURUS in the pontine part of the Raphe nuclei. Another pontine nucleus located directly rostral to the magnus nucleus is the nucleus raphe pontis.


Integral Membrane Protein
Membrane-Associated Proteins
Cell Surface Proteins
Integral Membrane Proteins
Cell Membrane Proteins
Surface Proteins
Membrane Protein
Membrane Proteins

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.


Neoplasms, Paranasal Sinus
Paranasal Sinus Cancer
Paranasal Sinus Neoplasms
Cancer of Paranasal Sinus

Tumors or cancer of the PARANASAL SINUSES.


Marine Hydrobiology
Biology, Marine
Marine Biology
Marine Ecology

The study of the origin, structure, development, growth, function, genetics, and reproduction of organisms which inhabit the OCEANS AND SEAS.


Fumarates
Fumarate Esters
Fumaric Acid Esters


Cell Therapy
Tissue Therapy
Therapy, Tissue
Therapy, Cell
Cell- and Tissue-Based Therapy

Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues.


Data Retrieval
Data Linkage
Information Retrieval
Data Files
Data Sources
Information Extraction
Data Storage and Retrieval
Information Storage and Retrieval
Information Storage
Machine-Readable Data Files
Data Storage

Organized activities related to the storage, location, search, and retrieval of information.


Disseminated Fusariosis
Invasive Pulmonary Fusariosis
Invasive Fusariosis
Fusarium Infection
Pulmonary Fusariosis
Fusariosis

OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.


Salix caprea
Salix alba
Salix
Salix viminalis
Cortex Salicis
Salix matsudana
Goat Willow
White Willow
Willow

A plant genus of the family Salicaceae. Members contain salicin, which yields SALICYLIC ACID.


Bilateral Deafness
Hearing Loss, Bilateral
Deafness Bilateral


Calcium Puffs
Calcium Spikes
Calcium Oscillations
Calcium Waves
Calcium Sparks
Calcium Signaling

Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.


Primitive Medicine
Medicine, Traditional
Folk Medicine
Home Remedies
Ethnomedicine
Indigenous Medicine
Medicine, Indigenous
Folk Remedies
Medicine, Folk
Traditional Medicine
Medicine, Primitive

Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.


Touch-me-not
Impatiens
Impatiens balsamina
Jewelweed

A plant genus of subsucculent annual or perennial plants in the family BALSAMINACEAE, order Geraniales.


Ventricle Remodeling
Ventricular Remodeling
Left Ventricle Remodeling
Cardiac Remodeling, Ventricular
Left Ventricular Remodeling
Myocardial Remodeling, Ventricular

The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.


Piperazine Tartrate (1:1), (R-(R*,R*))-isomer

An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm).  It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.


Activities of Daily Living
Activities, Daily Living
Chronic Limitation of Activity
Limitation of Activity, Chronic
ADL

The performance of the basic activities of self care, such as dressing, ambulation, or eating.


Cardiac Conduction System Diseases
Cardiac Conduction System Disease
Cardiac Conduction Defects
Cardiac Conduction Defect

Diseases characterized by pathological irregularities in the HEART CONDUCTION SYSTEM. They may be associated with other heart diseases and syndromes (e.g., BRUGADA SYNDROME; NEUROMUSCULAR DISEASE, HEART BLOCKS), isolated or may result from injuries. You can have a conduction disorder without having an arrhythmia, but some arrhythmias arise from conduction disorders. OMIM: 601144.


Antibody Deficiency Syndrome
Immunologic Deficiency Syndromes
Deficiency Syndrome, Immunologic
Immunological Deficiency Syndromes
Immunologic Deficiency Syndrome
Deficiency Syndromes, Immunologic
Deficiency Syndromes, Antibody

Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.


CH50 Assay
Complement Hemolytic Activity Assay
CH(50)
Serum Complement Titer
Total Hemolytic Complement
Complement H50
Whole Complement Titer
Hemolytic Titration Assay

A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay.


An anthracenedione-derived antineoplastic agent.


Glioma-Derived Vascular Endothelial Cell Growth Factor

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.


Signal Transducer and Activator of Transcription 3

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.


Transgrediens et Progrediens Palmoplantar Keratoderma

Erythrokeratodermia Figurata, Congenital Familial, in Plaques

Erythrokeratodermia Variabilis with Erythema Gyratum Repens

An autosomal dominant skin disease characterized by transient and variable noninflammatory ERYTHEMA and hyperkeratosis. It has been associated with mutations in the genes that code for CONNEXINS. Erythrokeratodermia variabilis inherited in an autosomal recessive fashion has also been reported. Affected individuals often develop PALMOPLANTAR KERATODERMA.


Formalin Test
Assessment, Pain
Nociception Tests
Analogue Pain Scale
Tourniquet Pain Test
Analgesia Tests
McGill Pain Scale
McGill Pain Questionnaire
Pain Measurement
Visual Analogue Pain Scale
Visual Analog Pain Scale
Analog Pain Scale
Pain Assessment

Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.


A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.


Eosine I Bluish
Eosine I Bluish, Dipotassium Salt
Eosine Bluish
D & C Red No. 27
Phloxin B
D.C. Red No. 27
Eosine B
Eosin B
Phloxine B

A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.


Doxorubicin
Doxorubicina Funk
Doxorubicina Ferrer Farm
DOXO-cell
Adriamycin
Doxorubicina Tedec
Doxorubicine Baxter
Onkodox
Doxorubicin Hexal
Doxorubicin NC
Adriblastine
Farmiblastina
Adriablastine
Urokit Doxo-cell
Adriblastina
Adriablastin
Adrimedac
Doxolem
Rubex
Doxorubicin Hydrochloride
Myocet
Doxotec
Adriblastin
Ribodoxo

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.


Alprostadil
Prostaglandin E1alpha
Caverject
Vasaprostan
Prostavasin
Sugiran
Prostin VR
Lipo-PGE1
PGE1alpha
Prostine VR
Prostaglandin E1
Edex
Viridal
Minprog
PGE1
Muse

A potent vasodilator agent that increases peripheral blood flow.


Monosaccharide sugar molecules that contain a five carbon backbone.


Chronic Disease Hospitals
Sanitaria, Tuberculosis
Hospitals, Chronic Disease
Sanitoria, Tuberculosis
Hospitals, Tuberculosis

Hospitals designed to treat patients with tuberculosis.


Compound Microscopy
Light Microscopy
Hand-Held Microscopy
Microscopy
Optical Microscopy
Simple Microscopy

The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.


Pityrosporum orbiculare
Pityrosporum
Malassezia furfur
Malassezia

A mitosporic fungal genus that causes a variety of skin disorders. Malassezia furfur (Pityrosporum orbiculare) causes TINEA VERSICOLOR.


Mice, HRS
Hairless Mouse
Mice, Hairless
Mouse, HRS
Mouse, Inbred HRS
Hairless Mice
Mice, hr
Mice, Inbred HRS

Mutant strains of mice that produce little or no hair.


Ajmalicine Oxindoles
Macroline Oxindoles
Oxazolidinone Derivatives
Macroline-Type Oxindoles
Oxindoles
Oxindole Alkaloids
Indolinone Derivatives
Oxindole Derivatives
Oxindole Alkaloid Derivatives
Ajmalicine-Type Oxindoles
Indolinones

Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl and a carbonyl at the pyrrole ring typically at the 2-position.


Demethyldaunorubicin
Karminomycin
Carminomicin
Carminomycin II
Demethyldaunomycin
Carminomycin III
Carubicin
Karminomicin
Carminomycin
Carubicin Hydrochloride
Rubeomycin A1
NSC-180024
Carminomycin I
NSC-180,024
Rubeomycin A

A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.


Breastfeeding
Breastfeeding, Exclusive
Breast Feeding
Breast Feeding, Exclusive


A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (RECEPTOR, ERBB-2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.


Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.


Neoplasms, Cranial Nerve, Benign
Benign Cranial Nerve Neoplasms
Tumors, Cranial Nerve, Malignant
Malignant Cranial Nerve Tumors
Neoplasms, Cranial Nerve
Cranial Neuroma, Benign
Malignant Cranial Nerve Neoplasms
Neoplasms, Cranial Nerve, Malignant
Cranial Nerve Tumors, Benign
Cranial Nerve Neoplasms
Cranial Nerve Tumors, Malignant
Cranial Nerve Neoplasms, Malignant
Tumors, Cranial Nerve, Benign
Benign Cranial Nerve Tumors
Cranial Nerve Neoplasms, Benign

Benign and malignant neoplasms that arise from one or more of the twelve cranial nerves.


Rue, Goat's
Goat Rue
Galega
Galega officinalis
Goat's Rue
Goats Rue
Galega orientalis

A plant genus of the family FABACEAE that contains galegine (GUANIDINES). Most of the other species have been reclassified to TEPHROSIA; a few to ASTRAGALUS PLANT; and INDIGOFERA.


RNA, G-Quadruplexes
DNA, Quadruplex
DNA G-Quadruplexes
Guanine-Tetrads
G-Quadruplexes, RNA
Guanine-Quartets
G-Quadruplexes
G-Quadruplexes, DNA
Quadruplex DNA
Tetraplex DNA
Guanine-Quadruplexes

Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)


Mianserin Hydrochloride
Org GB 94
Mianserin Monohydrochloride
Mianserin
Lerivon
Tolvon

A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.


A cyclohexane and pyridinone derivative that is used for the treatment of fungal infections of the skin and nails, and for treatment of VAGINAL YEAST INFECTIONS.


C8 Complement
Complement Component C8 gamma
Complement C8
Complement Component C8 alpha
Complement Component C8 gamma Chain
Complement 8
Complement Component C8 beta
Complement Component C8 alpha Chain
Complement Component 8
Complement Component C8 beta Chain

A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.


CD42b Antigens
Platelet Glycoprotein GPIb-IX Complex
Antigens, CD42a
Antigens, CD42b
Platelet Membrane Glycoprotein IX
CD42b Antigen
CD42d Antigens
Antigens, CD42d
Glycoprotein Ib beta
Glycoprotein Ib alpha
CD42c Antigen
CD42a Antigen
CD42c Antigens
CD42d Antigen
Platelet Membrane Glycoprotein V
Platelet Membrane Glycoprotein Ib
CD42a Antigens
Glycoprotein Ib
Antigens, CD42c
Platelet Glycoprotein IX
Glycoprotein Ib-IX Complex

Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.


Leukotriene D-4
Leukotriene D
Leukotriene D4
LTD4
Leukotrienes D

One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)


Tympanic Cavity
Tympanum
Ear, Middle
Middle Ear

The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.


Pulmonary Coin Lesions
Pulmonary Nodules, Solitary
Coin Lesion, Pulmonary
Solitary Pulmonary Nodules
Pulmonary Nodule, Solitary
Nodule, Solitary Pulmonary
Pulmonary Coin Lesion
Solitary Pulmonary Nodule
Coin Lesions, Pulmonary
Nodules, Solitary Pulmonary

A lung lesion that appears as a round coin-shaped shadow in the chest radiographs.


Elephants
Asiatic Elephants
Loxodonta
African Elephants
Elephas maximus

Large mammals in the family Elephantidae, with columnar limbs, bulky bodies, and elongated snouts. They are the only surviving members of the PROBOSCIDEA MAMMALS.


Pre-POMC
ACTH-Endorphin Precursor
ACTH-beta-Lipotropin Precursor
Pre-pro-opiocortin
Corticotropin-beta-Lipotropin Precursor
Pro-Opio-Melanocortin
Endorphin-ACTH Precursor
Pro-Opiocortin
Opiocortin
Proopiomelanocortin
POMC
Preproopiomelanocortin
Proopiocortin
Pro-ACTH-Endorphin
Pro-Opiomelanocortin

A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).


Look-Alike Sound-Alike Medication Errors

Lookalike Soundalike Drug Substitution Errors

Look-Alike Sound-Alike Drug Substitution Errors

Inappropriate use of drugs or medication due to unavailable or misleading information.


Neuropeptide Y-Like Immunoreactive Peptide

Neuropeptide Y Like Immunoreactive Peptide

A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.


A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.


Saposin C
beta-Glucosidase Stimulating Protein
Sphingolipid Activator Protein 1
Saposin B
Glucosylceramidase Activator
Sphingolipid Activator Protein 2
Gaucher Activator Protein
Coglucosidase
Saposins
beta-Glucosidase Activator Protein
Sphingolipid Activator Protein-1
SAP-A Protein
SAP-D Protein
Testibumin
Co-beta-Glucosidase
SAP-1 Sphingolipid Activator
Saposin D
Saposin A
SAP-C Protein

A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred to as prosaposin.


Precordial Catch
Chest Pain
Texidor's Twinge
Precordial Catch Syndrome

Pressure, burning, or numbness in the chest.


The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)


Miskleron
Athromidin
Clofibrate
Clofibric Acid, Ethyl Ester
Atromid S
Ethyl Chlorophenoxyisobutyrate
Atromid
Miscleron

A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)


Sodium Oxacillin
Penicillin, Methylphenylisoxazolyl
Oxacillin, Monosodium Salt, Monohydrate
Oxacillin Sodium
Oxacillin
Oxazocilline
Prostaphlin
Oxacillin, Monosodium Salt, Anhydrous

An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.


Nutrition Disorders, Child
Child Overnutrition
Child Malnutrition
Child Nutrition Disorders
Malnutrition in Children
Malnutrition, Child

Malnutrition occurring in children ages 2 to 12 years, which is due to insufficient intake of food, dietary nutrients, or a pathophysiologic condition which prevents the absorption and utilization of food. Growth and development are markedly affected.


Stichopus
Stichopus japonicus
Apostichopus japonicus

A genus of very large, epibenthic SEA CUCUMBERS in the family Stichopodidae, commercially harvested in Southeast Asia for food.


Polythene
HDPE
Low-Density Polyethylene
LDPE
Polyethylene
High-Density Polyethylene

A vinyl polymer made from ethylene. It can be branched or linear. Branched or low-density polyethylene is tough and pliable but not to the same degree as linear polyethylene. Linear or high-density polyethylene has a greater hardness and tensile strength. Polyethylene is used in a variety of products, including implants and prostheses.


Root Canal Sealants
Sealants, Root Canal
Root Canal Filling Materials

Materials placed inside a root canal for the purpose of obturating or sealing it. The materials may be gutta-percha, silver cones, paste mixtures, or other substances. (Dorland, 28th ed, p631 & Boucher's Clinical Dental Terminology, 4th ed, p187)


A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.


Toe Brachial Index
Ankle-Brachial Index
Toe-Brachial Index
Ankle Brachial Index

An alternative to the ankle-brachial index.


Hypertension, Goldblatt
Goldblatt Syndrome
Hypertension, Renovascular

HYPERTENSION due to renal ISCHEMIA. In 1934, Harry Goldblatt described that hypertension can be produced experimentally by using a clamp to obstruct blood flow to one kidney, the Goldblatt phenomenon.


A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency.


Lifespan
Life Span
Longevity
Length of Life

The entire maximum length of time of an organism's existence.


Hopenoid Derivatives
Hopanes
Baccharane Triterpenes
Fernane Derivatives
Gammacerane Derivatives
Hopane Derivatives
Lupanes
Gammaceranes
Adianane Derivatives
Lupane Derivatives
Fernanes
Triterpenes, Pentacyclic
Pentacyclic Triterpenes
Adiananes

Five-ring derivatives of dammarane having a chair-chair-chair-boat configuration. They include the lupanes, oleananes, amyrins, GLYCYRRHIZIC ACID, and soyasaponins.


Opioid Substitution Treatment
Opiate Replacement Therapy
Opiate Medication-Assisted Treatment
Opioid Replacement Therapy
Opioid Medication Assisted Treatment
Opioid Substitution Therapy
Medication Assisted Treatment of Opioid
Opiate Substitution Treatment

Opiate substitution treatment combined with COUNSELING; BEHAVIOR THERAPY and/or support services.


Medication Compliance
Medication Non-Compliance
Medication Nonadherence
Medication Persistence
Medication Noncompliance
Medication Non-Adherence
Medication Adherence

The duration of time from initiation to discontinuation of drug therapy.


Handroanthus impetiginosus
Lapacho Tree
Taheebo Tree
Tabebuia rosea
Tabebuia impetiginosa
Tabebuia avellanedae
Tabebuia palmeri
Tabebuia lapacho
Pau d'arco
Tabebuia

A plant genus of the family BIGNONIACEAE that is a source of lapachol and beta-lapachone.


Chinese Rhubarb
Rheum
Rhubarb
Da Huang
Rheum rhaponticum
Rheum officinale
Rheum tanguticum

A plant genus of the family POLYGONACEAE. Members contain chrysophanic acid, rhein, EMODIN, and other ANTHRAQUINONES. The roots were formerly used as PURGATIVES.


Health of Newborn Infants
Neonatal Health
Newborn Health
Health of the Newborn Infant
Infant Health
Newborn Infant Health
Baby Health

The concept covering the physical and mental conditions of INFANTS.


Familial Hibernation (Kleine-Levin) Syndrome

A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)


Wernicke Area
Wernicke's Area
Left Posterior Superior Temporal Gyrus
Posterior Superior Temporal Gyrus
Sensorisches Sprachzentrum

Functional region comprising posterior part of the SUPERIOR TEMPORAL GYRUS in the dominant cerebral hemisphere (see CEREBRAL DOMINANCE) and often portions of the PARIETAL LOBE. Along with BROCA AREA it is important in SPEECH and LANGUAGE processes. A lesion in the area is associated with WERNICKE APHASIA and CONDUCTION APHASIA.


Macaca siberu
M. leonina
Pig-tailed Macaque
Pig-Tailed Monkey
Pigtail Macaque
Monkey, Pigtailed
Monkey, Pig-Tailed
Macaca nemestrina siberu
Pig-tail Macaque
Macaca nemestrina
Macaca nemestrina leonina
Macaca nemestrina pagensis
Monkey, Pigtail

A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.


Neoplasms of Ear Auricle
Neoplasms, Ear
Cancer of Ear
Auricular Neoplasms
Auricular Cancer
Ear Neoplasms
Cancer of the Ear
Cancer of Ear Auricle
Ear Cancer
Neoplasms, Auricular

Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).


ADR-529
NSC-169780
ICRF-187
Razoxane, (S)-Isomer, Hydrochloride
Zinecard
Cardioxan
Dexrazoxane
Dexrazoxane Hydrochloride
Cardioxane
Razoxane, (S)-Isomer


NF90 Double-Stranded RNA-Binding Proteins

A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation.


Surgical Procedures, Endoscopic
Endoscopic Surgical Procedures
Endoscopic Surgical Procedure
Endoscopy, Surgical
Endoscopy
Surgical Endoscopy
Surgical Procedure, Endoscopic

Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.


Paralysis, Vocal Cord, Unilateral
Acquired Vocal Cord Palsy
Laryngeal Paralysis
Vocal Cord Palsy
Vocal Fold Palsy
Unilateral Vocal Cord Paralysis
Vocal Cord Paresis
Paralysis, Unilateral, Vocal Cord
Congenital Vocal Cord Palsy
Total Vocal Cord Paralysis
Unilateral Vocal Cord Paresis
Bilateral Vocal Cord Paresis
Partial Paralysis (Paresis) Vocal Cords
Vocal Cord Paralysis, Unilateral
Vocal Cord Palsy, Congenital
Unilateral Paralysis, Vocal Cord
Vocal Cord Paralysis
Recurrent Laryngeal Nerve Palsy
Laryngeal Nerve Palsy, Recurrent

Congenital or acquired paralysis of one or both VOCAL CORDS. This condition is caused by defects in the CENTRAL NERVOUS SYSTEM, the VAGUS NERVE and branches of LARYNGEAL NERVES. Common symptoms are VOICE DISORDERS including HOARSENESS or APHONIA.


Spinocerebellar Ataxia, Autosomal Dominant, with Sensory Axonal Neuropathy

Autosomal Dominant Cerebellar Ataxia, Type II

Olivopontocerebellar Atrophy, Holguin Type

OPCA with Macular Degeneration and External Ophthalmoplegia

Spinocerebellar Degeneration with Slow Eye Movements

Cerebellar Degeneration with Slow Eye Movements

Spinocerebellar Ataxia with Slow Eye Movements

A group of dominantly inherited, predominatly late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)


Leukemia, Natural Killer Cell Large Granular Lymphocytic

T-Cell Large Granular Lymphocytic Leukemia

Leukemia, T-Cell Large Granular Lymphocytic

Lymphoproliferative Disease of Large Granular Lymphocytes

Lymphoproliferative Disease of Granular Lymphocytes

NK-Cell Large Granular Lymphocytic Leukemia

Natural Killer Cell Large Granular Lymphocytic Leukemia

T-Cell Large Granular Lymphocyte Leukemia

A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.


Trichothecenes
Epoxytrichothecenes
Trichothecene Epoxides

Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.


Nursing Assistants
Nursing Auxiliaries
Nurses' Aides

Allied health personnel who assist the professional nurse in routine duties.


bcr-v-abl Oncogenes
abl Genes
v-abl Genes
bcr-abl Proto-Oncogenes
c-abl Genes
abl Oncogene
v-abl Oncogenes
c-abl Proto-Oncogenes
Genes, abl

Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.


Tropical Eosinophilia
Eosinophilia
Eosinophilia, Tropical

Abnormal increase of EOSINOPHILS in the blood, tissues or organs.


T-Cell Receptor Specificity
T-Cell Specificity
T-Cell Antigen Receptor Specificity
T-Cell Immunologic Specificity

The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule.


Nelfinavir Mesylate
AG1343
AG 1343
Nelfinavir
AG-1343
Viracept
Nelfinavir Monomethane Sulfonate

A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.


Cyclodepsipeptides
Depsipeptides
Depsipeptides, Cyclic
Cryptophycins

Peptolides forming 16-membered macrolides, composed of two ester linkages, two amide linkages and seven asymmetric centers. They have been found in CYANOBACTERIA and are TUBULIN MODULATORS.


Synthrom Syncumar Syncoumar Sintrom Mini-Sintrom Nicoumalone Sinthrome Acenocoumarin Sinkumar Acenocoumarol

A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)


Neurofibromatosis Type 3
Neurofibromatosis Syndrome
Neurofibromatosis 3
Neurofibromatoses
Neurofibromatosis
Multiple Neurofibromas

A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)


Convulsions, Benign Neonatal, Non-Familial

Benign Non-Familial Neonatal Convulsions

Benign Neonatal Non-Familial Convulsions

Benign Familial Infantile Convulsions Syndrome

Convulsions, Benign Familial Infantile, 3

Seizures, Benign Familial Neonatal-Infantile

Convulsions, Benign Familial Infantile, 1

Non-Familial Benign Neonatal Convulsions

Benign Familial Neonatal-Infantile Seizures

A condition marked by recurrent seizures that occur during the first 4-6 weeks of life despite an otherwise benign neonatal course. Autosomal dominant familial and sporadic forms have been identified. Seizures generally consist of brief episodes of tonic posturing and other movements, apnea, eye deviations, and blood pressure fluctuations. These tend to remit after the 6th week of life. The risk of developing epilepsy at an older age is moderately increased in the familial form of this disorder. (Neurologia 1996 Feb;11(2):51-5)


Mirounga
Seal, Harp
Seals, Earless
Seals, True
Halichoerus grypus
Phocidae
Seal, Elephant
Phoca groenlandica
Pagophilus groenlandicus
Seal, Gray

The best known species of earless seals, inhabiting the North Atlantic and Arctic Oceans. Harp seals get their name from a horse-shaped band of black fur on the back of the male adults. They were previously considered part of the genus Phoca.


PIAS3 Protein Inhibitor of Activated STAT

PIAS4 Protein Inhibitor of Activated STAT

PIAS2 Protein Inhibitor of Activated STAT

PIAS1 Protein Inhibitor of Activated STAT

A family of structurally related proteins that are constitutively expressed and that negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. PIAS proteins inhibit the activity of signal transducers and activators of transcription.


Postnidation Embryo Development
Postnidation Embryo Development, Animal
Embryogenesis
Embryo Development
Embryonic Development
Prenidation Embryo Development, Animal
Postimplantation Embryo Development
Post-implantation Embryo Development
Embryonic Programming
Pre-implantation Embryo Development
Preimplantation Embryo Development

Permanent alteration of tissue structures and functions in the EMBRYO as a result of its environment, either positive or negative.


Aphasia, Fluent
Wernicke Aphasia
Fluent Aphasia, Wernicke's
Aphasia, Jargon
Dysphasia, Fluent
Sensory Aphasia
Dysphasia, Wernicke
Aphasia, Wernicke
Receptive Aphasia
Dysphasia, Sensory
Dysphasia, Receptive
Aphasia, Psychosensory
Dysphasia, Wernicke's
Aphasia, Posterior

Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke's area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846)


Well-Differentiated Oligodendroglioma
Oligodendroglioma, Childhood
Oligodendroglioma, Adult
Anaplastic Oligodendroglioma
Mixed Oligodendroglioma-Ependymoma
Mixed Oligodendroglioma-Astrocytoma
Oligodendroglioma
Oligodendroglioma, Well-Differentiated
Oligodendroblastoma

A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)


Chilaiditi Anomaly
Chilaiditi Syndrome
Chilaiditi's Anomaly
Chilaiditi's Syndrome

Interposition of a portion of the colon (e.g., SIGMOID COLON) between the liver and the diaphragm. It is associated with abdominal pain, vomiting, constipation, anorexia and volvulus. Chilaiditi anomaly refers to asymptomatic interposition.


Lama guanicoe
Llamas
Vicunas
Vicugna vicugna
Lama pacos
Alpacas
Lama glama guanicoe
Guanacos
Camelids, New World
Vicugna pacos
Lama glama

Camelidae of the Americas. The extant species are those originating from South America and include alpacas, llamas, guanicos, and vicunas.


S. cay
C. flavius
Cebus xanthosternos
Sapajus
Tufted Capuchins
Robust Capuchins
Sapajus xanthosternos
Cebus flavius
S. flavius
Blond Capuchin
Cebus elegans
Sapajus flavius
Yellow-Breasted Capuchin
Sapajus cay

A genus of the family CEBIDAE, subfamily CEBINAE, consisting of capuchin monkeys with characteristic tufts of hair over the eyes and sides of the head. Many were formerly classified under genus CEBUS. Sapajus inhabits the forests of Central and South America.


Cunninghamia lanceolata
Cunninghamia
Fir, Chinese

A plant genus of the family TAXODIACEAE. Members contain DITERPENES.


A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.


Leukotriene A
Leukotriene A4
LTA4
Leukotriene A-4
Leukotrienes A

(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)


Macrocystis pyrifera
Macrocystis
Kelp, Giant


Lymphoma, Nodular, Mixed Lymphocytic Histiocytic

Nodular Large Follicular Center-Cell Lymphoma

Lymphoma, Nodular, Large Follicular Center Cell

Lymphoma, Follicular, Mixed Lymphocytic-Histiocytic

Lymphoma, Follicular, Small and Large Cleaved-Cell

Lymphocytic Lymphoma, Nodular, Poorly-Differentiated

Lymphoma, Follicular, Mixed Small and Large Lymphoid

Lymphoma, Small Cleaved-Cell, Follicular

Lymphocytic Lymphoma, Nodular, Poorly Differentiated

Lymphoma, Lymphocytic, Nodular, Poorly Differentiated

Lymphoma, Small Cleaved Cell, Follicular

Lymphoma, Lymphocytic, Nodular, Poorly-Differentiated

Lymphoma, Nodular, Large Follicular Center-Cell

Lymphoma, Nodular, Mixed Small and Large Cell

Lymphoma, Follicular, Small and Large Cleaved Cell

Lymphoma, Nodular, Mixed Lymphocytic-Histiocytic

A low-grade malignant lymphoma of predominantly follicular pattern. Follicles are of relatively uniform size and shape and the cells are usually somewhat larger than normal lymphocytes. Nuclei are irregular with prominent indentations and cytoplasm can rarely be identified. Cells exhibiting these characteristics are often called centrocytes.


Celiac Ganglia
Ganglia, Sympathetic
Sympathetic Ganglia
Ganglion, Sympathetic
Celiac Ganglion

Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.


Cyclic GMP-Dependent Protein Kinase Type I

A cyclic GMP-dependent protein kinase subtype that is expressed in SMOOTH MUSCLE tissues and plays a role in regulation of smooth muscle contraction. Two isoforms, PKGIalpha and PKGIbeta, of the type I protein kinase exist due to alternative splicing of its mRNA.


Official Medical Missions
Medical Missions, Official
Medical Missions
Missions, Official Medical

Travel by a group for the purpose of undertaking a health-care related project of short-term duration.


Coatomer-Coated Vesicles
Coat Protein Complex-Coated Vesicles
COPI-Coated Vesicles
COP-Coated Vesicles
COPII-Coated Vesicles

TRANSPORT VESICLES formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles is covered with a lattice-like network of COP (coat protein complex) proteins, either COPI or COPII. COPI coated vesicles transport backwards from the cisternae of the GOLGI APPARATUS to the rough endoplasmic reticulum (ENDOPLASMIC RETICULUM, ROUGH), while COPII coated vesicles transport forward from the rough endoplasmic reticulum to the Golgi apparatus.


Cavernous Hemangioma
Strawberry Hemangiomas
Hemangioma, Cavernous
Cavernous Angioma
Angioma, Cavernous

A tumor-like mass with large vascular space that is filled with blood or lymph.


Global Positioning System
Geographical Information Systems
Global Positioning Systems
Geographic Information Systems

Satellite-based systems providing worldwide continuous position, velocity, time, and related data.


Demser
alpha-Methyltyrosine, (L)-Isomer
alpha-Methyl-para-tyrosine
Racemetirosine
DL-Tyrosine, alpha-methyl-
alpha-Methyltyrosine
alpha-Methyltyrosine, (D,L)-Isomer
alpha-Methyl-p-tyrosine
Metirosine
Metyrosine
alpha-MPT
alpha-Methyltyrosine, (+,-)-Isomer
alpha-Methyltyrosine Hydrochloride

An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)


A non-steroidal estrogen antagonist (as the 1:1 citrate) most commonly used as a research tool in animal studies.


Deoxycholic Acid, Sodium Salt, 12beta-Isomer

A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.


Buprenorphine
Prefin
Buprex
Buprenex
Temgesic
6029-M
Subutex
Temgésic
RX-6029-M
Buprenorphine Hydrochloride

A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.


An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.


Digestive System Physiological Phenomenon

Digestive System Physiological Phenomena

Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts.


Orbicularis Oculi Reflex
Reflex, Blink
Blinking
Reflex, Orbicularis Oculi
Orbicularis Oculi Reflexes
Corneal Reflexes
Reflex, Corneal
Blink Reflexes
Winking

Brief closing of the eyelids by involuntary normal periodic closing, as a protective measure, or by voluntary action.


Mental Suffering
Life Stress
Stressor, Psychological
Stress, Psychological
Psychological Stress
Stress, Psychologic
Suffering

Severe psychological and/or spiritual distress.


Bilateral Slipped Capital Femoral Epiphyses

Unilateral Slipped Capital Femoral Epiphyses

Bilateral Slipped Capital Femoral Epiphysis

Unilateral Slipped Capital Femoral Epiphysis

A developmental deformity in which the metaphysis of the FEMUR moves proximally and anteriorly away from FEMUR HEAD (epiphysis) at the upper GROWTH PLATE. It is most common in male adolescents and is associated with a greater risk of early OSTEOARTHRITIS of the hip.


E2A Immunoglobulin Enhancer Binding Factor E12

E2A Immunoglobulin Enhancer Binding Factor E47

A basic helix-loop-helix transcription factor that plays a role in determining cell fate during embryogenesis. It forms a heterodimer with TWIST-RELATED PROTEIN 1 and ACHAETE-SCUTE GENE COMPLEX-related TRANSCRIPTION FACTORS.


Intracisternal A-Particle Elements
Intracisternal A-Particle Genes
Gene, Intracisternal A Particle
Genes, Intracisternal A-Particle
IAP Elements

Genes of IAP elements (a family of retrovirus-like genetic elements) which code for virus-like particles (IAPs) found regularly in rodent early embryos. ("Intracisternal" refers to the cisternae of the endoplasmic reticulum.) Under certain circumstances, such as DNA hypomethylation they are transcribed. Their transcripts are found in a variety of neoplasms, including plasmacytomas, neuroblastoma, rhabdomyosarcomas, teratocarcinomas, and colon carcinomas.


Cholecystokinin Pancreozymin C-Terminal Octapeptide

An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.


Delayed Awakening, Post-Procedural
Residual Block
Residual Neuromuscular Blockade
Residual Neuromuscular Block
Postoperative Residual Curarisation
Delayed Awakening, Post-Anesthesia
Delayed Awakening from Anesthesia
Delayed Recovery from Anesthesia
Residual Paralysis, Post-Anesthesia
Delayed Regaining of Consciousness
Delayed Return of Consciousness
Postoperative Residual Weakness
Delayed Emergence from Anesthesia
Postoperative Residual Curarization

Postoperative morbidity in patients recovering from general anesthesia where a depressed neuromuscular response due to residual PARESIS continues beyond a defined ANESTHESIA RECOVERY PERIOD.


Hoe-893d
Penbutolol Sulfate (2:1)
Betapressin
Penbutolol
Penbutolol Sulfate

A nonselective beta-blocker used as an antihypertensive and an antianginal agent.


A tetrahydroisoquinoline derivative and ANGIOTENSIN CONVERTING ENZYME inhibitor that is used in the treatment of HYPERTENSION and HEART FAILURE.


Embryonic Structures, Mammalian
Mammalian Embryo
Mammalian Embryo Structures
Embryo, Mammalian
Mammalian Embryonic Structures

The anatomical parts that make up a mammalian organism in the early stages of development.


Protein Localization Processes, Cellular

A mechanism which uses selective gates to actively transport proteins from one cellular compartment to another.


Leukemia, Myeloid
Myelocytic Leukemia
Leukemia, Granulocytic
Granulocytic Leukemia
Leukemia, Monocytic, Chronic
Leukemia, Myelogenous
Myelogenous Leukemia
Monocytic Leukemia, Chronic
Leukemia, Myelocytic
Myeloid Leukemia

Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.


Chilli Pepper
Sweet Pepper
Chili Pepper
Pimiento
Capsicum annuum
Jalapeno Pepper
Cayenne Pepper
Bell Pepper
Green Pepper
Capsicum
Cayenne
Hot Pepper
Chile Pepper
Red Pepper
Paprika

A plant genus of the family SOLANACEAE. The hot peppers yield CAPSAICIN, which activates VANILLOID RECEPTORS. Several varieties have sweet or pungent edible fruits that are used as vegetables when fresh and spices when the pods are dried.


A neurological condition that is characterized by uncontrolled rapid irregular movements of the eye (OPSOCLONUS) and the muscle (MYOCLONUS) causing unsteady, trembling gait. It is also known as dancing eyes-dancing feet syndrome and is often associated with neoplasms, viral infections, or autoimmune disorders involving the nervous system.


A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.


Outcome and Process Assessment, Health Care

Outcome and Process Assessment (Health Care)

Evaluation procedures that focus on both the outcome or status (OUTCOMES ASSESSMENT) of the patient at the end of an episode of care - presence of symptoms, level of activity, and mortality; and the process (ASSESSMENT, PROCESS) - what is done for the patient diagnostically and therapeutically.


Toruloma
Cryptococcal Meningitis
Meningitis, Cryptococcal
Granulomous Cerebral Cryptococcosis
Cerebral Cryptococcosis

Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)


Metagonimus yokogawai
Yokogawa's Fluke
Heterophyidae
Heterophyes
Metagonimus

A family of intestinal flukes of the class Trematoda which occurs in animals and man. Some of the genera are Heterophyes, Metagonimus, Cryptocotyle, Stellantchasmus, and Euryhelmis.


Chem mart Gemfibrozil
Lipox Gemfi
Decrelip
Lipur
Gemfibrosil
Jezil
Gemfibrozil
Terry White Chemists Gemfibrozil
Healthsense Gemfibrozil
Ausgem
Gemfibrozilo Ur
Bolutol
DBL Gemfibrozil
Lopid
Novo-Gemfibrozil
Gemfibrozilo Bayvit
CI-719
Gen-Gemfibrozil
Lipazil
Trialmin
SBPA Gemfibrozil
Apo-Gemfibrozil
Nu-Gemfibrozil
GenRX Gemfibrozil
PMS-Gemfibrozil
Pilder
Gemfi 1A Pharma
Litarek
Gemfibrozilo Bexal
Gemhexal
Lopid R

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.


Receptors, Gonadotropins
Receptors, Pituitary Gonadotropin
Menotropin Receptors
Receptors, Menotropin
Pituitary Gonadotropin Receptors
Gonadotopin Receptor
Receptors, Gonadotropin
Pituitary Gonadotropin Receptor
Gonadotropin Receptors

Those protein complexes or molecular sites on the surfaces of gonadal and other sensitive cells that bind gonadotropins and thereby modify the functions of those cells; hCG, LH, and FOLLICLE STIMULATING HORMONE are the major specific gonadotropins.


Receptors, Epinephrine
Norepinephrine Receptors
Receptors, Norepinephrine
Receptors, Adrenergic
Adrenergic Receptor
Epinephrine Receptors
Adrenergic Receptors
Adrenoceptors

Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.


Laser-Induced Shockwave Lithotripsy
Lithotripsy, Laser
Laser Lithotripsy
Shockwave Lithotripsy, Laser-Induced

Fragmentation of CALCULI, notably urinary or biliary, by LASER.


Silkmoths, Giant
Silkworms, Giant
Antheraea
Giant Silkmoths
Moths
Giant Silkworms

Insects of the suborder Heterocera of the order LEPIDOPTERA.


Myelographic Cisternography
Cisternography, Myelographic
Myelography

X-ray visualization of the spinal cord following injection of contrast medium into the spinal arachnoid space.


Monkey Hemorrhagic Disease Virus
Arterivirus
Hemorrhagic Disease Virus, Simian
Simian hemorrhagic fever virus

A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is EQUARTEVIRUS.


Nasturtium
Nasturtium officinale
Rorippa nasturtium-aquaticum

A plant genus of the family BRASSICACEAE. Nasturtium is also used as a common name for TROPAEOLUM. The common name of watercress is also used for RORIPPA & TROPAEOLUM. This is the most popular of the edible cresses, is a hardy creeping perennial plant, native to Europe but extensively naturalized elsewhere in moist places.


Heredofamilial Neuritis with Brachial Plexus Predilection

Amyotrophy, Hereditary Neuralgic, with Predilection for Brachial Plexus

A syndrome associated with inflammation of the BRACHIAL PLEXUS. Clinical features include severe pain in the shoulder region which may be accompanied by MUSCLE WEAKNESS and loss of sensation in the upper extremity. This condition may be associated with VIRUS DISEASES; IMMUNIZATION; SURGERY; heroin use (see HEROIN DEPENDENCE); and other conditions. The term brachial neuralgia generally refers to pain associated with brachial plexus injury. (From Adams et al., Principles of Neurology, 6th ed, pp1355-6)


Suprachoroidal Space
Choroidal Effusions
Choroidal Detachment
Ciliochoroidal Effusions
Ciliochoroidal Detachment

Space created between the CHOROID and the SCLERA due to choroidal detachment.


A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.


Phenol, Sodium Salt
Hydroxybenzene
Phenolate Sodium
Sodium Phenolate
Carbolic Acid
Carbol
Phenol

An antiseptic and disinfectant aromatic alcohol.


Melizide Minidiab Glydiazinamide Minodiab Glypidizine Glipizide Ozidia Glupitel Glucotrol Glidiazinamide K-4024 Mindiab

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.


Industrial Accidents
Accidents, Industrial
Accidents, Occupational
Occupational Accidents

Unforeseen occurrences, especially injuries in the course of work-related activities.


Systemic Vascular Resistance
Peripheral Resistance
Pulmonary Vascular Resistance
Vascular Resistance
Total Peripheral Resistance

The total vascular resistance in the systemic circulation. It is equal to the mean arterial BLOOD PRESSURE minus the CENTRAL VENOUS PRESSURE divided by CARDIAC OUTPUT.


Mono-ADPRibosylation
Mono(ADP-Ribosyl)ation
ADP-Ribosylation
(ADP-Ribosyl)ation
(ADPRibosyl)ation
Mono ADPRibosylation
MARylation
ADPRibosylation
Mono-ADP-Ribosylation
ADP Ribosylation
MonoADPRibosylation
Mono(ADPRibosyl)ation

Post-translational modification of proteins with ADENOSINE DIPHOSPHATE RIBOSE.


Mydocalm
Tolperisone Hydrochloride
Midocalm
Mydeton
Tolperisone

A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)


Drug Parachuting
Drug Bombing
Substance Abuse, Oral
Oral Substance Abuse

Abuse, overuse, or misuse of a substance by ingestion.


Nephroid Carcinoma
Hypernephroma
Renal Collecting Duct Carcinoma
Renal Cell Cancer
Clear Cell Renal Cell Carcinoma
Chromophil Renal Cell Carcinoma
Collecting Duct Carcinoma (Kidney)
Carcinoma, Hypernephroid
Adenocarcinoma, Renal Cell
Adenocarcinoma, Renal
Renal Cell Carcinoma
Adenocarcinoma Of Kidney
Renal Cell Carcinoma, Papillary
Clear Cell Renal Carcinoma
Collecting Duct Carcinoma
Chromophobe Renal Cell Carcinoma
Collecting Duct Carcinoma of the Kidney
Papillary Renal Cell Carcinoma
Grawitz Tumor
Sarcomatoid Renal Cell Carcinoma
Carcinoma, Renal Cell

A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.


Spleen Cancer
Splenic Cancer
Neoplasms, Splenic
Spleen Neoplasms
Cancer of the Spleen
Splenic Neoplasms
Cancer of Spleen


Anterior Cruciate Ligament Tears
Anterior Cruciate Ligament Injuries
ACL Injuries
Anterior Cruciate Ligament Tear
ACL Tears
Anterior Cruciate Ligament Injury

Sprain or tear injuries to the ANTERIOR CRUCIATE LIGAMENT of the knee.


Gel Filtration Chromatography
Chromatography, Exclusion
Chromatography, Size Exclusion
Gel Filtration
Gel Chromatography
Molecular Sieve Chromatography
Chromatography, Gel Permeation
Exclusion Chromatography
Chromatography, Gel
Chromatography, Molecular Sieve
Gel Permeation Chromatography

A technique for separating molecules based on molecular size. The solid phase commonly consists of porous beads packed in a column.


Microbiological Processes
Microbial Concepts
Microbiological Phenomenon
Microbiologic Phenomena
Microbial Phenomena
Microbiologic Concepts
Phenomena, Microbiologic
Microbiological Process
Microbiological Phenomena

Physiological processes and properties of microorganisms, such as ARCHAEA; BACTERIA; RICKETTSIA; VIRUSES; and FUNGI.


UDPglucose 4-Epimerase Deficiency Disease

UTP Hexose-1-Phosphate Uridylyltransferase Deficiency

UTP-Hexose-1-Phosphate Uridylyltransferase Deficiency Disease

Deficiency Disease, Galactose-1-Phosphate Uridyl-Transferase

Deficiency Disease, UDPglucose 4-Epimerase

Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease

UDPGlucose Hexose-1-Phosphate Uridylyltransferase Deficiency

A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (PRIMARY OVARIAN INSUFFICIENCY); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)


Plant Physiological Processes
Physiology, Plant
Plant Physiological Phenomena
Plant Physiologic Phenomenon
Plant Physiological Phenomenon
Plant Physiology
Plant Physiologic Phenomena
Plant Physiological Process

The physiological processes, properties, and states characteristic of plants.


c-fos Proteins
Fos-Related Antigens
FRAs
Proto-Oncogene Proteins fos
Fos B Protein
p55(c-fos)
Proto-Oncogene Proteins c-fos
fos Proto-Oncogene Proteins
p55 c-fos
Antigens, Fos-Related
Proto-Oncogene Products c-fos

Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.


Lactobacillus delbrueckii subspecies bulgaricus

Lactobacillus delbrueckii subsp. bulgaricus

A subspecies of Lactobacillus delbrueckii, formerly classified as a separate species, that is used for producing YOGURT and as a PROBIOTIC.


Kv3.1 Potassium Channel
KCNC2 Potassium Channel
Kv3 Potassium Channels
Kv3.2 Potassium Channel
Shaw Potassium Channel Protein Family
KCNC1 Potassium Channel
Shaw Potassium Channels

A shaker subfamily that is prominently expressed in NEURONS and are necessary for high-frequency, repetitive firing of ACTION POTENTIALS.


Physicians, Junior
Attending Physician, Hospital
Hospital Medical Staffs
Hospital Attending Physicians
Hospital Medical Staff
Attending Physicians, Hospital
Hospital Attending Physician
Medical Staff, Hospital
Registrars, Hospital
Medical Staffs, Hospital

Professional medical personnel approved to provide care to patients in a hospital.


Male Pseudohermaphroditism Due to Androgen Insensitivity

A disorder also known as partial androgen insensitivity syndrome (PAIS). These patients exhibit partial resistance to androgenic and metabolic effects of TESTOSTERONE.


Thistle, Plume
Thistle, Common
Cirsium arvense
Thistle, Canadian
Thistle, White
Cirsium
Thistle, Yellowspine

A plant genus of the family ASTERACEAE. Members contain pectolinarin (a flavonoid glycoside).


Cancer of Eye
Eye Neoplasms
Cancer of the Eye
Neoplasms, Eye
Eye Cancer


Mercaptopurine
Mecaptopurine Anhydrous
6-Thiohypoxanthine
6H-Purine-6-thione, 1,7-dihydro-
Purinethol
1,7-Dihydro-6H-purine-6-thione
6-Mercaptopurine
Leupurin
BW 57-323H
Mercaptopurina Wellcome
6-Thiopurine
6-Mercaptopurine Monohydrate
Puri-Nethol
Purimethol

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.


SAR Elements
Scaffold-Attached Regions
Matrix Attachment Regions
MAR-SAR Recognition Signature Sequence
MAR Elements
MRS Sequence
Matrix-Attached Regions
Scaffold Attachment Regions

Regions of the CHROMATIN or DNA that bind to the NUCLEAR MATRIX. They are found in INTERGENIC DNA, especially flanking the 5' ends of genes or clusters of genes. Many of the regions that have been isolated contain a bipartite sequence motif called the MAR/SAR recognition signature sequence that binds to MATRIX ATTACHMENT REGION BINDING PROTEINS.


Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.


PLC beta1
PLC beta2
Phospholipase C-beta3
Phospholipase C beta1
Phospholipase C-beta
PLC beta3
PLC beta4
Phospholipase C beta
Phospholipase C beta4
Phospholipase C beta3
Phospholipase C-beta1
Phospholipase C-beta4
PLC beta
Phospholipase C beta2
Phospholipase C-beta2

A phosphoinositide phospholipase C subtype that is primarily regulated by its association with HETEROTRIMERIC G-PROTEINS. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues.


A plant genus. Members contain BUFANOLIDES.


Bauer-Kirby Disk-Diffusion Method
Kirby-Bauer Disk-Diffusion Method
Etest
Epsilometer Test
Disk Diffusion Antimicrobial Tests

A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.


Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.


Tetraphenylborate, Potassium Salt
Tetraphenylborate, Barium Salt (2:1)
Tetraphenylborate
Tetraphenylborate, Ammonium Salt
Kalignost
Sodium Tetraphenylborate
Tetraphenylboron Sodium
Tetraphenylboron
Tetraphenylborate Sodium Salt

An anionic compound that is used as a reagent for determination of potassium, ammonium, rubidium, and cesium ions. It also uncouples oxidative phosphorylation and forms complexes with biological materials, and is used in biological assays.


Purine Receptors
Purinoceptors
Receptors, Purinergic
Receptors, Methyladenine
Purinoceptor
Purinergic Receptors
Purine Receptor
Methyladenine Receptors
Receptors, Purine

Cell surface proteins that bind PURINES with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized classes of purinergic receptors in mammals are the P1 receptors, which prefer ADENOSINE, and the P2 receptors, which prefer ATP or ADP.


Low-density lipoprotein particles with density between 1.045 and 1.063 g/ml.


A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.


Heterogeneous Nuclear Ribonucleoprotein A2-B1

Heterogeneous-Nuclear Ribonucleoprotein Group A-B

A class of closely related heterogeneous-nuclear ribonucleoproteins of approximately 34-40 kDa in size. Although they are generally found in the nucleoplasm, they also shuttle between the nucleus and the cytoplasm. Members of this class have been found to have a role in mRNA transport, telomere biogenesis and RNA SPLICING.


Marantaceae Calathea Arrowroot Maranta Thalia

A plant genus of the family MARANTACEAE that is the source of arrowroot starch.


Saint Johnswort
Hypericum perforatum
St. Johns Wort
Saint Johns Wort
Hypericum
St. John's Wort
St. Johnswort
Saint John's Wort

Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.


A syndrome of cutaneous changes associated with sweat retention and extravasation of sweat at different levels in the skin. Miliaria rubra, or prickly heat, results from apocrine duct obstruction. The sweat then seeps into the epidermis, producing pruritic erythematous papulovesicles. (From Dorland, 27th ed)


Xenorhabdus
Xenorhabdus nematophila
Xenorhabdus nematophilus

A genus of gram-negative, facultatively anaerobic rod-shaped cells which are motile by peritrichous flagella. Late in the growth cycle, spheroplasts or coccoid bodies occur, resulting from disintegration of the cell wall. The natural habitat is the intestinal lumen of certain nematodes. (From Bergey's Manual of Determinative Bacteriology, 9th ed)


Non-Heterosexuals
Homosexuals
LBG Persons
Sexual Dissidents
Lesbians
GLBTQ Persons
Women Who Have Sex With Women
GLBT Persons
LGBTQ Persons
Sexual Minorities
Sexual and Gender Minorities
Queers
Bisexuals
Gender Minorities
Men Who Have Sex With Men
LGBT Persons
Gays
Lesbigay Persons
Non-Heterosexual Persons

Individuals including lesbian, gay, bisexual, transgender, queer, intersex, gender non-conforming people, and other populations whose sexual orientation or GENDER IDENTITY and reproductive development is considered outside cultural, societal, or physiological norms.


Right Atrial Isomerism
Visceral Heterotaxy
Ivemark Syndrome
Situs Ambiguus with Polysplenia
Situs Ambiguus
Right Atrial Isomerism with Asplenia
Heterotaxy Syndrome
Situs Ambiguus with Asplenia
Asplenia Syndrome
Asplenia with Cardiovascular Anomalies
Left Atrial Isomerism
Polysplenia Syndrome
Situs Ambiguus Viscerum
Left Atrial Isomerism with Polysplenia

Congenital deformity in which the internal organs of the THORAX and the ABDOMEN are abnormally arranged across the mediolateral body axis.


Laryngeal Cancer
Laryngeal Neoplasms
Larynx Neoplasms
Larynx Cancer
Cancer of the Larynx
Cancer of Larynx
Neoplasms, Laryngeal

Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.


Staff Participation
Worker Participation
Workplace Engagement
Staff Engagement
Work Engagement
Employee Participation
Employee Engagement

Extent to which members of a workplace perceive their emotional commitment to and involvement in the organization and its goals.


Portable electronics device for storing and playing audio and or media files. Uses MPEG-4 standard.


Fenoterol Hydrobromide
p-Hydroxyphenyl-orciprenaline
Berotec
Fenoterol Hydrochloride
Th-1165a
Phenoterol
Fenoterol
p-Hydroxyphenylorciprenaline
Berotek
Partusisten

A synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.


Isoaspartate
Isoaspartic Acid
beta-Aspartic Acid
beta-Aspartate

An ASPARTIC ACID residue in polypeptide chains that is linked at the beta-carboxyl group instead of at the normal, alpha-carboxyl group, polypeptide linkage. It is a result of the spontaneous decomposition of aspartic acid or ASPARAGINE residues.


Pyracetam
Nootrop
Ciclofalina
Piracetam
2-Pyrrolidone-N-Acetamide
Dinagen
Piracebral
Axonyl
Normabraïn
Nootropyl
Avigilen
Nootropil
Piracetrop
Memo-Puren
Sinapsan
Pirazetam
Cerepar N
Cerebroforte
Gabacet
Piracetam-RPh
UCB-6215
Geram
Piracetam AbZ
Cuxabrain
Pyramem

A compound suggested to be both a nootropic and a neuroprotective agent.


Coronavirus Infections
Infections, Coronavirus
Middle East Respiratory Syndrome
MERS (Middle East Respiratory Syndrome)

A viral disorder characterized by SARS (Severe Acute Respiratory Syndrome)-like symptoms caused by MERS-CoV (MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS).


Drug-induced Linear IgA Bullous Dermatosis

Autoimmune disease characterized by subepidermal blisters and linear deposition of autoantibodies at the dermoepidermal junction. The accumulated autoantibodies are of IMMUNOGLOBULIN A and occasionally IMMUNOGLOBULIN G classes against epidermal BASEMENT MEMBRANE proteins. The dermatosis is sometimes associated with malignancies and use of certain drugs (e.g., VANCOMYCIN).


Primary Central Nervous System Phaeohyphomycosis

Central Nervous System Phaeohyphomycosis, Primary

Phaeohyphomycosis, Central Nervous System, Primary

CNS infections caused by neurotropic dematiaceous fungi that contain melanin in their cell walls. The infections often result in BRAIN ABSCESS; ENCEPHALITIS; and MENINGITIS in patients who are often immunocompetent. The common causative fungi include members Cladophialophora bantiana, Exophiala dermatitidis, Rhinocladiella mackenziei, and Ochroconis gallopavum. R. mackenziei infection is seen almost exclusively in patients from the MIDDLE EAST.


Sulfokinase
Aryl Sulfotransferase
Phenol Sulfokinase
Arylsulfotransferase
Phenol Sulfotransferase
Phenol Sulfotransferase M
Acetaminophen Sulphotransferase
Catecholamine Sulfotransferase B
Catecholamine Sulfotransferase A
Phenolsulfokinase
Flavonoid Sulfotransferase
Phenolsulfotransferase P
Phenol Sulfotransferase P
Dopamine Sulfotransferase

A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.


An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.


Cytotoxic Brain Edema
Cerebral Edema, Cytotoxic
Brain Edema
Cerebral Edema
Intracranial Edema
Vasogenic Brain Edema
Cytotoxic Cerebral Edema
Vasogenic Cerebral Edema
Brain Swelling
Cerebral Edema, Vasogenic

Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)


Autokinetic Illusions
Illusions
Illusions, Auditory
Effect, Autokinetic
Autokinetic Effect
Illusions, Kinesthetic
Illusions, Tactile
Illusions, Visual

The misinterpretation of a real external, sensory experience.


Inflammation involving the skin of the extremities, especially the hands and feet. Several forms are known, some idiopathic and some hereditary. The infantile form is called Gianotti-Crosti syndrome.


Failure, Equipment
Medical Device Failure
Failure, Medical Device
Malfunction, Equipment
Device Failures, Medical
Failures, Medical Device
Defects, Equipment
Misuse, Equipment
Device Failure
Equipment Failure
Device Failure, Medical

Failure of equipment to perform to standard. The failure may be due to defects or improper use.


Coix
Coicis Semen
Adlay Seed Plant
Job's Tears
Coix lachryma-jobi

A plant genus of the family POACEAE. The seed is used in folk medicine (DRUGS, CHINESE HERBAL).


Trichocyte-Type Cytokeratins
Inner Root Sheath Keratins
Keratins, Hair
Keratins, Hard Tissue
Keratins, Hair-Specific
Keratins, Inner Root Sheath
Trichocyte Cytokeratins
Hair-Specific Cytokeratins

Keratins that are specific for hard tissues such as HAIR; NAILS; and the filiform papillae of the TONGUE.


Bearberry
Arctostaphylos
Arctostaphylos uva-ursi
Uva-ursi


Forel's Field H1
Nucleus Campi Foreli
Field H1 of Forel
Lenticular Fasciculus
Forel's Field H2
Fasciculus Thalamicus
Subthalamus
Nucleus of Field H
Nucleus of Ansa Lenticularis
Thalamic Fasciculus

A transition zone in the anterior part of the diencephalon interposed between the thalamus, hypothalamus, and tegmentum of the mesencephalon. Components of the subthalamus include the SUBTHALAMIC NUCLEUS, zona incerta, nucleus of field H, and the nucleus of ansa lenticularis. The latter contains the ENTOPEDUNCULAR NUCLEUS.


Compound 48-80
p-Methoxy-N-methylphenethylamine
BW 48-80
Agent 48-80
Preparation 48-80

A potent mast cell degranulator. It is involved in histamine release.


Gyrus Cinguli Anterior
Gyrus, Cingulate
Cingular Gyrus
Cingulate Gyrus
Gyrus Cinguli
Posterior Cingulate
Superior Mesial Regions
Anterior Cingulate Cortex
Anterior Cingulate
Anterior Cingulate Gyrus
Posterior Cingulate Gyri
Cingulate Body
Cingulate Cortex
Posterior Cingulate Cortex
Posterior Cingulate Gyrus
Posterior Cingulate Region
Cingulate Area
Cingulate Region

The GRAY MATTER of the cingulate gyrus, possessing multiple intracortical and subcortical connections, and involved in motor control and decision making.


Atypical Interstitial Pneumonia of Cattle

Pneumonia, Atypical Interstitial, of Cattle

A cattle disease of uncertain cause, probably an allergic reaction.


Endosteal Hyperostosis, Autosomal Recessive

Spondyloepiphyseal Dysplasia Tarda, X-Linked

Myotonic Myopathy, Dwarfism, Chondrodystrophy, And Ocular And Facial Abnormalities

X-Linked Spondyloepiphyseal Dysplasia Tarda

Spondylo-Epimetaphyseal Dysplasia With Myotonia

Abnormal development of cartilage and bone.


Fulminant Meningococcal Sepsis with Adrenal Apoplexy

Purpura Fulminans (Waterhouse-Friderichsen Syndrome)

A condition of HEMORRHAGE and NECROSIS of the ADRENAL GLAND. It is characterized by rapidly developing ADRENAL INSUFFICIENCY; HYPOTENSION; and widespread cutaneous PURPURA.


A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.


Cancer Staging
Neoplasm Staging
Tumor Staging
TNM Staging System
TNM Staging
Staging, Neoplasm
TNM Classification

Classification of neoplasm according to the characteristics of the tumor (T), such as size; the degree of involvement of the lymph nodes (N); and the amount of detectable metastasis (M).


Procyclid
Tricyclamol
Procyclidine
Procyclidine Hydrochloride
Kemadren
Osnervan
Arpicolin
Kemadrin
Mucinil

A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.


Acupuncture Analgesia
Acupuncture Anesthesia
Analgesia, Acupuncture
Anesthesia, Acupuncture

Use of ACUPUNCTURE to block the afferent nerve impulses from reaching the brain to reduce the sensation of pain for surgery.


Catheterization, Pulmonary Artery
Catheterization, Swan-Ganz
Pulmonary Artery Catheterization
Swan-Ganz Catheterization

Placement of a balloon-tipped catheter into the pulmonary artery through the antecubital, subclavian, and sometimes the femoral vein. It is used to measure pulmonary artery pressure and pulmonary artery wedge pressure which reflects left atrial pressure and left ventricular end-diastolic pressure. The catheter is threaded into the right atrium, the balloon is inflated and the catheter follows the blood flow through the tricuspid valve into the right ventricle and out into the pulmonary artery.


Monoclonal Antibody MEDI-493
Synagis
Palivizumab
MEDI-493
MEDI 493

A humanized monoclonal antibody and ANTIVIRAL AGENT  that is used to prevent RESPIRATORY SYNCYTIAL VIRUS INFECTIONS in high risk pediatric patients.


Spectroscopy, Nuclear Magnetic Resonance

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).


Metallurgy
Industries, Heavy
Heavy Industries

The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494)


Anti-Mutagenic Effect
Anti-Mutagenic Effects
Anti-Mutagenic Agents
Antimutagenic Agents
Antimutagenic Effect
Antimutagenic Effects
Antimutagens

Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.


Kreteks Tobacco
Kreteks
Tobacco, Bidi
Cigars
Cigarillos
Bidis Tobacco
Pipe Tobacco
Tobacco Products
Bidis
Cigarettes

Roll of dried and finely cut TOBACCO leaves wrapped in a cylinder of thin paper used for SMOKING.


Recombinant Human Dimeric TNF Receptor Type II-IgG Fusion Protein

A recombinant version of soluble human TNF receptor fused to an IgG FC fragment that binds specifically to TUMOR NECROSIS FACTOR and inhibits its binding with endogenous TNF receptors. It prevents the inflammatory effect of TNF and is used to treat RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS and ANKYLOSING SPONDYLITIS.


Hypophosphatemic Vitamin D-Resistant Rickets

Hypophosphatemia, Vitamin D-Resistant Rickets

A disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; resulting from lack of phosphate reabsorption by the kidneys and possible defects in vitamin D metabolism.


Endothelium, Anterior Chamber
Endothelium, Corneal
Corneal Endothelium
Epithelium, Anterior Chamber
Anterior Chamber Epithelium

Single layer of large flattened cells covering the surface of the cornea.


v-erbB Genes
Genes, erbB1
EGFR Genes
Epidermal Growth Factor Receptor Genes
erbB-1 Genes
c-erbB-1 Genes
c-erbB-1 Proto-Oncogenes
Genes, EGFR
v-erbB Oncogenes
Genes, erbB-1

The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.


Taste, Altered
Parageusia
Taste, Distorted
Dysgeusia

A condition characterized by alterations of the sense of taste which may range from mild to severe, including gross distortions of taste quality.


Bombax ceiba
Bombax
Salmalia malabaricum
Bombax malabaricum

A plant genus of the family BOMBACACEAE. The fine silky hairs covering the seeds have been used like kapok (CEIBA) for floatation, stuffing, and insulation.


Extranuclear Inheritance
Cytoplasmic Inheritance
Extrachromosomal Inheritance

Vertical transmission of hereditary characters by DNA from cytoplasmic organelles such as MITOCHONDRIA; CHLOROPLASTS; and PLASTIDS, or from PLASMIDS or viral episomal DNA.


RNA, Nuclear
RNA, Chromosomal
Chromosomal RNA
Nuclear RNA

RNA molecules found in the nucleus either associated with chromosomes or in the nucleoplasm.


Idiopathic Interstitial Pneumonitis - from Asbestos Exposure

Pulmonary Fibrosis - from Asbestos Exposure

A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.


Neurotic Depression, Persistent Depressive Disorder

Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)


Physical Phenomenon
Physical Concepts
Physical Phenomena
Physical Process
Physical Processes

The entities of matter and energy, and the processes, principles, properties, and relationships describing their nature and interactions.


Organopyrophosphates
Phosphates, Organic
Phosphoric Acid Esters
Organophosphates


Catastrophic Flooding
Floods
Flooding, Catastrophic

Sudden onset water phenomena with different speed of occurrence. These include flash floods, seasonal river floods, and coastal floods, associated with CYCLONIC STORMS; TIDALWAVES; and storm surges.


Liver Abscess, Amoebic
Abscess, Liver, Amebic
Amoebiasis, Hepatic
Abscess, Amebic, Hepatic
Hepatic Entamoebiasis
Entamoebiasis, Hepatic
Hepatic Amebiasis
Hepatic Amoebiasis
Amebiasis, Hepatic
Liver Abscess, Amebic
Abscess, Hepatic, Amebic
Hepatic Abscess, Amoebic

Single or multiple areas of PUS due to infection by any ameboid protozoa (AMEBIASIS). A common form is caused by the ingestion of ENTAMOEBA HISTOLYTICA.


Complement 3 Convertase, Alternative Pathway

Complement C3 Convertase, Alternative Pathway

Complement 3b-Associated Factor B-fragment Bb

Cobra venom factor (CVF) is a COMPLEMENT C3B analog. With Bb, CVF forms the CVFBb complex, a COMPLEMENT C3 convertase with a half-life of 7 h at body temperature as compared to 1.5 min for the C3bBb complex. The cobra venom-derived enzyme causes continuous COMPLEMENT ACTIVATION and depletion of downstream complement components.


The volatile portions of chemical substances perceptible by the sense of smell.


Gasterosteiformes
Mullets
Synbranchidae
Gasterosteidae
Smegmamorpha
Seahorses
Sticklebacks
Eels, Swamp
Swamp Eels

Common name for fish found mostly in the family Gasterosteidae. The three-spine stickleback (Gasterosteus aculeatus) is frequently studied.


Light, Visible
Photoradiation
Visible Radiation
Light
Radiation, Visible

That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.


Mustine
Nitrogen Mustard
Mechlorethamine N-Oxide
Mechlorethamine
Chlorethazine
Mechlorethamine Hydrochloride
Cloramin
Embichin
NSC-762
NSC-10107
Nitromin
Mitomen
Nitrogranulogen
Nitrogen Mustard N-Oxide
Methylchlorethamine
Bis(2-chloroethyl)methylamine
Mechlorethamine Oxide
Chlormethine
Caryolysine
Mechlorethamine Hydrochloride N-Oxide
Mustargen

A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.


Unilateral Hearing Loss
Deafness, Unilateral
Deafness Unilateral
Hearing Loss, Unilateral

Partial or complete hearing loss in one ear.


Closures, Health Facility
Health Facility Closure
Facility Closure, Health
Closures, Hospital
Health Facility Closures
Hospital Closure
Closure, Health Facility
Facility Closures, Health
Closure, Hospital
Hospital Closures

The closing of any health facility, e.g., health centers, residential facilities, and hospitals.