Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).


Fraud, Scientific
Scientific Misconduct
Fraudulent Data
Research Misconduct
Scientific Dishonesty
Ethics in Publishing

Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.


Nephropathy, IGA
Glomerulonephritis, IGA
IGA Nephropathy
Berger's Disease
IGA Glomerulonephritis
Iga Nephropathy 1
Berger Disease
Nephritis, IGA Type
Immunoglobulin A Nephropathy

A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.


Liver-Specific Organic Anion Transporter, LST-1

Liver-Specific Organic Anion Transporter 1

Solute Carrier Family-21(Organic Anion Transporter), Member 6 Protein

An organic anion transporter found in human and mouse liver. It is capable of transporting a variety organic anions and mediates sodium-independent uptake of bile in the liver.


Wiskott-Aldrich Syndrome Protein, Neuronal

Neuronal Wiskott-Aldrich Syndrome Protein

Wiskott-Aldrich Syndrome Gene-Like Protein

A member of the Wiskott-Aldrich syndrome protein family that is found at high levels in NERVE CELLS. It interacts with GRB2 ADAPTOR PROTEIN and with CDC42 PROTEIN.


Isoactin Actin G-Actin alpha-Isoactin F-Actin beta-Actin N-Actin Actins alpha-Actin gamma-Actin

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.


Immunodominant Domains
Epitopes, Immunodominant
Immunodominant Sites
Antigens, Immunodominant
Immunodominant Epitopes
Antigenic Determinants, Immunodominant
Immunodominant Regions
Immunodominant Determinants

Subunits of the antigenic determinant that are most easily recognized by the immune system and thus most influence the specificity of the induced antibody.


A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.


Receptors, Tumor Necrosis Factor, Member 17

Tumor Necrosis Factor Receptor Superfamily, Member 17

A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES. It has specificity for B CELL ACTIVATING FACTOR and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.


Penile Implantation
Penile Prosthesis Implantation

Surgical insertion of cylindric hydraulic devices for the treatment of organic ERECTILE DYSFUNCTION.


Lactose Intolerance
Hypolactasia
Dairy Product Intolerance
Milk Sugar Intolerance
Alactasia
Lactose Malabsorption

The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.


Homologous Transplants
Allogeneic Grafts
Allografts
Allogeneic Transplants
Homografts

Tissues, cells, or organs transplanted between genetically different individuals of the same species.


Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.


Plant Extracts, Chinese
Drugs, Chinese Herbal
Chinese Drugs, Plant
Chinese Herbal Drugs

Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.


Righting Response
Righting Reflex
Reflex, Righting

The instinctive tendency (or ability) to assume a normal position of the body in space when it has been displaced.


Chlorobiaceae
Bacteria, Green Sulfur
Chlorobi
Green Sulfur Bacteria

A phylum of anoxygenic, phototrophic bacteria including the family Chlorobiaceae. They occur in aquatic sediments, sulfur springs, and hot springs and utilize reduced sulfur compounds instead of oxygen.


Cytochrome P-450 IVA
Omega-1 Hydroxylase
Fatty Acid Omega-Hydroxylase
CYP4A
Cytochrome P-450 4A
Alkane 1-Monooxygenase
Lauric Acid Hydroxylase
Laurate Omega-Hydroxylase
Alkane Hydroxylase
Cytochrome P-450 CYP4A
Alkane 1-Hydroxylase
Lauric Acid Omega-hydroxylase
Lauric Acid (Omega-1)-Hydroxylase
Omega-Lauryl Hydroxylase
Lauric Acid Monooxygenase
Omega-Hydroxylase

A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as OCTANES and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.


Lipoprotein HDL2
Lipoproteins, HDL2
HDL2 Lipoprotein
High Density Lipoprotein HDL2
HDL-2
High Density Lipoprotein-2

Low-density subclass of the high-density lipoproteins, with particle sizes between 8 to 13 nm.


Follicle Stimulating Hormone
Follitropin
FSH (Follicle Stimulating Hormone)
Follicle-Stimulating Hormone

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.


A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.


Infusions, Intra-Osseous
Infusions, Intraosseous

The administration of medication or fluid through a needle directly into the bone marrow. The technique is especially useful in the management of pediatric emergencies when intravenous access to the systemic circulation is difficult.


A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.


Antibody Production
Antibody Formation
Antibody Response

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.


Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK

A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.


Cancellous Bone
Trabecular Bone
Spongy Bone

A type of osseous tissue which makes up the inner part of bone.  It has a spongy, honeycomb-like structure with struts or trabecula and contains the BONE MARROW. It has higher rate of BONE REMODELING turnover than CORTICAL BONE.


Carcinoma, Ovine Pulmonary
Ovine Pulmonary Adenomatosis
Pulmonary Adenomatosis, Ovine
Adenomatosis, Pulmonary, Ovine
Adenomatosis, Ovine Pulmonary
Ovine Pulmonary Carcinoma
Jaagsiekte
Pulmonary Ovine Adenomatosis

A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.


A synthetic nonapeptide (Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro) which is identical to the peptide from the venom of the snake, Bothrops jararaca. It inhibits kininase II and ANGIOTENSIN I and has been proposed as an antihypertensive agent.


Lymphogranuloma Inguinale
Lymphogranuloma Venereum

Subacute inflammation of the inguinal lymph glands caused by certain immunotypes of CHLAMYDIA TRACHOMATIS. It is a sexually transmitted disease in the U.S. but is more widespread in developing countries. It is distinguished from granuloma venereum (see GRANULOMA INGUINALE), which is caused by Calymmatobacterium granulomatis.


G-Protein-Coupled Receptor Kinase 2
beta-Adrenergic Receptor Kinase 1

A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS. It may play an essential role in regulating myocardial contractile response.


Aotus trivirgatus
Night Monkey, Northern
Monkey, Northern Night
Humboldt's Night Monkey

A species in the family AOTIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys.


rev Gene Products
rev Protein
Gene Products, rev
Gene Product, rev

Trans-acting nuclear proteins whose functional expression are required for retroviral replication. Specifically, the rev gene products are required for processing and translation of the gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. rev is short for regulator of virion.


Anesthesia, Regional
Anesthesia, Conduction

Injection of an anesthetic into the nerves to inhibit nerve transmission in a specific part of the body.


Metabolic Skin Diseases
Skin Diseases, Metabolic

Diseases of the skin associated with underlying metabolic disorders.


Intergenerational Relations
Nest Leaving
Generation Gap
Relations, Intergenerational

The interactions between individuals of different generations. These interactions include communication, caring, accountability, loyalty, and even conflict between related or non-related individuals.


A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).


Eosinophil Chemotactic Factors
Chemotactic Factors, Eosinophil
Eosinophil Chemotaxins

Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ECF-A, released mainly by mast cells.


Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

A subvariety of CADASIL characterized by the high frequency of MIGRAINE. The acronym stands for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts, Leukoencephalopathy, and Migraine.


rho Guanine Nucleotide Dissociation Inhibitor 3

rho GDP Dissociation Inhibitor (GDI) gamma

rho Guanine Nucleotide Dissociation Inhibitor gamma

A rho GDP-dissociation inhibitor subtype that has a unique C-terminal alpha helical membrane-binding domain. It is found bound to CYTOPLASMIC VESICLES such as those associated with the GOLGI APPARATUS.


Fanconi Hypoplastic Anemia
Fanconi Pancytopenia
Fanconi's Anemia
Anemia, Fanconi
Fanconi Anemia
Fanconi Panmyelopathy

Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)


Specificity Protein 2 Transcription Factor

A ubiquitously expressed Sp transcription factor that binds to the consensus DNA sequence GGGCGGGAC.


Rhabdoviridae Infections
Infections, Rhabdoviridae

Virus diseases caused by RHABDOVIRIDAE. Important infections include RABIES; EPHEMERAL FEVER; and vesicular stomatitis.


Hereditary Mucosal Leukokeratosis
Leukokeratosis, Hereditary Mucosal
White Sponge Nevus of Cannon

An autosomal dominant disorder that is manifested by thickened spongiform ORAL MUCOSA with a white opalescent tint. Other MUCOSAL TISSUE may also be involved mucosa found in the VAGINA; RECTUM, and NASAL CAVITY may be similarly involved. This form of LEUKOKERATOSIS can be caused by a mutation in the gene for KERATIN 4 and is not considered a PRENEOPLASTIC CONDITION.


Cell-Line Identification
Cell Line Misidentification
Cell Line Authentication
Cell-Line Authentication

Techniques used to characterize and confirm the identity of a CELL LINE. Characterization involves authentication to verify that it matches the original description of the cells and ensures that they are not cross-contaminated with another cell line. This is done to avoid attributing data incorrectly to the wrong cell line.


Class III Phosphatidylinositol 3-Kinase, p150 Subunit

Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 4, p150

Class III Phosphatidylinositol 3-Kinase Regulatory Subunit

Phosphoinositide-3-kinase, Regulatory Subunit 4

A 150 kDa protein serine-threonine kinase that is found as a regulatory subunit of the class III phosphatidylinositol 3-kinases. The protein is believed to play an important role in the regulation of vesicular trafficking with the cell.


Head Impulse Test
Head Heave Test
Head Thrust Test

Identification of SACCADES during a rapid head rotation to assess VESTIBULOOCULAR REFLEX.


Congenital Micrognathism
Mandibular Micrognathia
Congenital Micrognathia
Mandibular Micrognathism
Micrognathism
Micrognathia


L-Ascorbic Acid Peroxidase
Ascorbate Peroxidase
Ascorbate Peroxidases

Peroxidases that utilize ASCORBIC ACID as an electron donor to reduce HYDROGEN PEROXIDE to WATER. The reaction results in the production of monodehydroascorbic acid and DEHYDROASCORBIC ACID.


Cardiorenal Syndrome
Cardio-Renal Syndrome
Reno-Cardiac Syndrome
Renocardiac Syndrome

Condition where a primary dysfunction of either heart or kidney results in failure of the other organ (e.g., HEART FAILURE with worsening RENAL INSUFFICIENCY).


N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.


Any of several Old World finches of the genus Serinus.


Specialties, Nursing
Nursing Specialties
Nursing Specialty
Specialty, Nursing

Various branches of nursing practice limited to specialized areas.


Damage-Associated Molecular Pattern Molecules

Danger-Associated Molecular Pattern Molecules

A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.


A structural polymer of the bacterial cell envelope consisting of sugars and amino acids which is responsible for both shape determination and cellular integrity under osmotic stress in virtually all bacteria.


A plant species of the family AQUIFOLIACEAE known for ritual use by Amazonian Jivaro Indians.


The use of art as an adjunctive therapy in the treatment of neurological, mental, or behavioral disorders.


Uridine Diphosphate Glucose Dehydrogenase

An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC 1.1.1.22.


P450 CYP2C9 Inducers
Cytochrome P-450 CYP2C9 Inducers
CYP2C9 Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP2C9.


Zonula Occludens-1 Protein
Zona Occludens 1 Protein
Tight Junction Protein ZO-1
Tight Junction Protein 1

A 195-kDa zonula occludens protein with similarity to MEMBRANE-ASSOCIATED GUANYLATE KINASES. It is distinguished by the presence of a ZU5 domain at the C-terminal of the molecule.


The species Panthera tigris, a large feline inhabiting Asia. Several subspecies exist including the Siberian tiger and Sumatran tiger.


Patency of the Ductus Arteriosus
Patent Ductus Arteriosus
Ductus Arteriosus, Patent
Patent Ductus Arteriosus Familial

A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.


5 alpha-Reductase
Cholestenone 5 alpha-Reductase
4-Ene Steroid 5 alpha-Reductase

An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.


Attachment Loss, Periodontal
Periodontal Attachment Loss

Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.


An enzyme of the oxidoreductase class that catalyzes the conversion of beta-D-glucose and oxygen to D-glucono-1,5-lactone and peroxide. It is a flavoprotein, highly specific for beta-D-glucose. The enzyme is produced by Penicillium notatum and other fungi and has antibacterial activity in the presence of glucose and oxygen. It is used to estimate glucose concentration in blood or urine samples through the formation of colored dyes by the hydrogen peroxide produced in the reaction. (From Enzyme Nomenclature, 1992) EC 1.1.3.4.


Genetic Engineering
Intervention, Genetic
Engineering, Genetic
Genetic Intervention

Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.


Maleic Anhydrides
2,5-Furandiones
Maleic Anhydride

Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.


A plant genus of the family POACEAE that contains allergen Dac g I.


Typhus, Sao Paulo
Sao Paulo Typhus
Rocky Mountain Spotted Fever
Rickettsia rickettsii Infection
Brazilian Spotted Fever

An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.


Dermatophagoides
Housedust Mites
Pyroglyphidae
House Dust Mites
Dust Mites, House
Euroglyphus
Mites, House Dust

Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.


A moon-shaped carpal bone which is located between the SCAPHOID BONE and TRIQUETRUM BONE.


A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.


Tricuspid Valve Incompetence
Tricuspid Regurgitation
Tricuspid Valve Insufficiency
Tricuspid Incompetence
Tricuspid Valve Regurgitation

Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.


Therapeutic Plasma Adsorption
Plasmapheresis
Therapeutic Immunoadsorption
Double Filtration Plasmapheresis
Therapeutic Plasmapheresis

Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.


Delphi Technique
Delphi Technic
Delphi Studies

An iterative questionnaire designed to measure consensus among individual responses. In the classic Delphi approach, there is no interaction between responder and interviewer.


Endometrial Ablation
Endometrial Ablation Techniques
Endometrial Ablation Technics

Procedures used for the targeted destruction of the mucous membrane lining of the uterine cavity.


Malate Dehydrogenase
Malic Dehydrogenase
NAD-Malate Dehydrogenase

An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.


A mass of tissue, including skin and muscle, that has been cut away from surrounding areas for transplantation.


Letters as Topic
Correspondence as Topic

Works on written communication between persons or between institutions or organizations.


All the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER; URETHRA, and the organs of reproduction - ovaries, UTERUS; FALLOPIAN TUBES; VAGINA; and CLITORIS in women and the testes; SEMINAL VESICLES; PROSTATE; seminal ducts; and PENIS in men.


Yersiniosis
Yersinia Infections
Infections, Yersinia
Yersinia enterocolitica Infection

Infections with bacteria of the genus YERSINIA.


Private Duty Nursing
Nursing, Private Practice
Nursing, Private Duty
Private Practice Nursing

The practice of nursing by a registered or licensed nurse to care for a specific patient in a health facility or in the home.


Circumscribed Lobar Atrophy of the Brain

Dementia with Lobar Atrophy and Neuronal Cytoplasmic Inclusions

A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)


Education Departments, Hospital
Education Department, Hospital
Hospital Education Department

Hospital department responsible for administering educational and training activities pertaining to health for patients and staff.


Signaling Lymphocytic Activation Molecule Family Member 1

A 70-kDa SLAM family receptor that consists of an extracellular IMMUNOGLOBULIN-LIKE DOMAIN and an IMMUNOGLOBULIN C2-SET DOMAIN. It is expressed primarily by THYMOCYTES and activated T-LYMPHOCYTES, as well as by MACROPHAGES and DENDRITIC CELLS. It binds SLAMF1 receptors on other cells to mediate T-cell maturation and proliferation. It is also a receptor for the MEASLES VIRUS.


Pancreas, Artificial
Artificial Pancreas

Devices for simulating the activity of the pancreas. They can be either electromechanical, consisting of a glucose sensor, computer, and insulin pump or bioartificial, consisting of isolated islets of Langerhans in an artificial membrane.


A plant genus of the family POACEAE that is used for forage.


An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.


Eczema, Vesicular Palmoplantar
Eczema, Dyshidrotic
Eczema, Dyshydrotic
Vesicular Palmoplantar Eczema
Pompholyx

A recurrent eczematous reaction characterized by the development of vesicular eruptions on the palms and soles, particularly along the sides and between the digits. It is accompanied by pruritus, a burning sensation, and hyperhidrosis. The disease is self-limiting, lasting only a few weeks. (Dorland, 27th ed)


Psychological Warfare
Psychologic Warfare
Warfare, Psychological

The manipulation of psychological influences, primarily concerned with morale, to strengthen the ability of one's own country and weaken the enemy.


Phospholipases A2, Group III
Group III Secretory Phospholipase A2
Group III Phospholipases A2
Phospholipase A2-III

A subcategory of secreted phospholipases A2 with specificity for PHOSPHATIDYLETHANOLAMINES and PHOSPHATIDYLCHOLINE. It occurs as a component of VENOMS and as a mammalian secretory phospholipase A2. The creation of this group is based upon similarities in the structural determinants of the enzymes including a long amino-terminal domain, a conserved group III-specific domain, and a long carboxyl-terminal domain.


Menetrier's Disease
Gastritis, Hypertrophic
Gastritis, Familial Giant Hypertrophic
Giant Hypertrophic Gastritis
Menetrier Disease

GASTRITIS with HYPERTROPHY of the GASTRIC MUCOSA. It is characterized by giant gastric folds, diminished acid secretion, excessive MUCUS secretion, and HYPOPROTEINEMIA. Symptoms include VOMITING; DIARRHEA; and WEIGHT LOSS.


p-Chloromercuribenzoic Acid
4-Chloromercuribenzoic Acid
PCMB
para-Chloromercuribenzoate

An organic mercurial used as a sulfhydryl reagent.


A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. They are coniferous evergreen trees and should not be confused with hemlock plants (CICUTA and CONIUM).


Rejection (Psychology)
Rejection, Psychology
Psychological Rejection

Non-acceptance, negative attitudes, hostility or excessive criticism of the individual which may precipitate feelings of rejection.


S cerevisiae
Yeast, Brewer's
Baker Yeast
Saccharomyces cerevisiae
Brewer's Yeast
Baker's Yeast
Yeast, Baker's

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.


RNase I
Ribonuclease I
Ribonuclease (Pancreatic)
Ribonuclease, Pancreatic
Pancreatic RNase
RNase A
Ribonuclease A

An enzyme that catalyzes the endonucleolytic cleavage of pancreatic ribonucleic acids to 3'-phosphomono- and oligonucleotides ending in cytidylic or uridylic acids with 2',3'-cyclic phosphate intermediates. EC 3.1.27.5.


Pleomorphic Malignant Fibrous Histiocytoma

The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.


Removal of a drug from the market due to a problem occurring in the manufacture or distribution of the product.


Professional Education
Education, Professional

Formal education and training in preparation for the practice of a profession.


Rochalimaea quintana
Rickettsia quintana
Bartonella quintana

A species of gram-negative bacteria in which man is the primary host and the human body louse, Pediculus humanus, the principal vector. It is the etiological agent of TRENCH FEVER.


Crystalline Lens
Lens, Crystalline
Eye Lens
Lens, Eye

A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.


A once-popular mercury containing topical antiseptic.


A plant genus of the family FABACEAE that is widely used as ground cover and forage and known for the edible beans, VICIA FABA.


Postphlebitic Syndrome
Postphlebitic Ulcer
Postphlebitic Disease

A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous VARICOSE VEINS are usually present. Leg pain may occur after long period of standing.


Calcium-Dependent Protein Tyrosine Kinase

A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.


Pancreatic Polypeptide Cells
Pancreatic Polypeptide-Secreting Cells
PP Cells, Pancreatic

A group of islet cells (10-35%) which secrete PANCREATIC POLYPEPTIDE, a hormone that regulates APPETITE and FOOD INTAKE.


Myopia, Pathological
Myopia, Progressive
Myopia, Degenerative

Myopia that increases at an abnormally rapid rate or increases after maturity (Hofstetter et al, Dictionary of Visual Science and Related Clinical Terms, 5th ed).


Hair Cells, Auditory
Auditory Hair Cells
Cochlear Hair Cells

Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.


Intentionally using oneself as a research subject.


Fox-Fordyce Syndrome
Miliaria, Apocrine
Fox-Fordyce Disease

Chronic pruritic disease, usually in women, characterized by small follicular papular eruptions in APOCRINE GLANDS areas. It is caused by obstruction and rupture of intraepidermal apocrine ducts.


Meksamine Mexamine Methoxytryptamine 5-Methoxytryptamine

Serotonin derivative proposed as potentiator for hypnotics and sedatives.


Planning, Health Facility
Health Facility Planning
Health Facility Conversion

Areawide planning for health care institutions on the basis of projected consumer need.


Leydig Cell Tumor
Interstitial Cell Tumor

Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.


An acyclic state that resembles PREGNANCY in that there is no ovarian cycle, ESTROUS CYCLE, or MENSTRUAL CYCLE. Unlike pregnancy, there is no EMBRYO IMPLANTATION. Pseudopregnancy can be experimentally induced to form DECIDUOMA in the UTERUS.


Reimbursement, Health Insurance
Insurance, Health, Reimbursement
Third-Party Payments
Third-Party Payers
Health Insurance Reimbursement

Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)


Bilio-Pancreatic Bypass
Bilio-Pancreatic Diversion
Biliopancreatic Bypass
Bilio Pancreatic Diversions
Biliopancreatic Diversion
Bilio Pancreatic Bypasses

A surgical procedure which diverts pancreatobiliary secretions via the duodenum and the jejunum into the colon, the remaining small intestine being anastomosed to the stomach after antrectomy. The procedure produces less diarrhea than does jejunoileal bypass.


Physicians specializing in medical, surgical, and physical methods used to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.


Multidrug Efflux Pump Genes
Multidrug Resistance Gene
Genes, MDR
MDR Genes

Genes for MEMBRANE TRANSPORT PROTEINS that confer resistance to toxic compounds. Several superfamilies of these multidrug export proteins are known and found in both prokaryotes and eukaryotes.


Fibrinogen
Blood Coagulation Factor I
Factor I
gamma-Fibrinogen
Coagulation Factor I

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.


Injections, Intralesional
Intralesional Injections

Injections introduced directly into localized lesions.


Receptor, EphB5
EphB5 Receptor
Cek9 Kinase
Receptor Tyrosine Kinase Cek9

An eph family receptor found at high levels in adult THYMUS and RETINA. In embryonic tissues it is found in many developing organs.


Marketing of Health Services
Marketing, Health Services
Marketing Services, Health
Services, Health Marketing
Health Services Marketing

Application of marketing principles and techniques to maximize the use of health care resources.


Rutin
Rutoside
3-Rhamnosyl-Glucosyl Quercetin
Quercetin-3-Rutinoside

A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.


Paragangliomas, Familial Nonchromaffin, 1

A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the CAROTID BODY; GLOMUS JUGULARE; GLOMUS TYMPANICUM; AORTIC BODIES; and the female genital tract. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. (From Stedman, 27th ed)


The type species of the genus AVIPOXVIRUS. It is the etiologic agent of FOWLPOX.


Xenotropic murine leukemia virus-related virus

An endogenous GAMMARETROVIRUS from the germ line of mice but isolated from humans. It has close similarity to xenotropic MURINE LEUKEMIA VIRUS.


Passage of light through body tissues or cavities for examination of internal structures.


Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.


Bhopal Chemical Accident
Bhopal Accidental Release

1984 accident in Bhopal, INDIA at a PESTICIDES facility, resulting when WATER entered a storage tank containing ISOCYANATES. The following accidental chemical release and uncontrolled reaction resulted in several thousand deaths.


Keratoconjunctivitis, Vernal
Conjunctivitis, Allergic
Allergic Conjunctivitis
Conjunctivitis, Atopic
Conjunctivitis, Giant Papillary
Conjunctivitis, Vernal

Conjunctivitis due to hypersensitivity to various allergens.


Oligoclonal IgM
Oligoclonal Bands
Oligoclonal IgG
Oligoclonal Immunoglobulins
Immunoglobulins, Oligoclonal

Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.


ARC
Lymphadenopathy Syndrome
AIDS-Related Complex

A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.


Seborrheic Dermatitis
Seborrhea
Dermatitis Seborrheica
Dermatitis, Seborrheic

A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.


Competition, Economic
Economic Competition

The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.


Chamaecrista
Pea, Partridge
Partridgepea
Pea, Sensitive

A plant genus of the family FABACEAE. Some species were reclassified from CASSIA and Senna.


Food-Drug Interactions
Drug-Food Interactions
Food Interactions

The pharmacological result, either desirable or undesirable, of drugs interacting with components of the diet. (From Stedman, 25th ed)


Corynebacterium Infections
Infections, Corynebacterium

Infections with bacteria of the genus CORYNEBACTERIUM.


Deoxyadenosines
Deoxyadenosine Derivatives
Adenylyldeoxyribonucleosides
Adenine Deoxyribonucleosides

Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.


Amino Acid Transport System A Proteins
System A Transporter Proteins
System A Transporter
Amino Acid Transporter A
Amino Acid Transport System A

A sodium-dependent neutral amino acid transporter that accounts for most of the sodium-dependent neutral amino acid uptake by mammalian cells. The preferred substrates for this transporter system include ALANINE; SERINE; and GLUTAMINE.


Feeling or showing sorrow; the sense of being unhappy. It is related to DEPRESSION but is not synonymous.


An enzyme that catalyzes the acetyltransferase reaction using ACETYL CoA as an acetyl donor and dihydrolipoamide as acceptor to produce COENZYME A (CoA) and S-acetyldihydrolipoamide. It forms the (E2) subunit of the PYRUVATE DEHYDROGENASE COMPLEX.


Surgery, Mohs
Mohs Surgery
Micrographic Surgery, Mohs'
Moh's Micrographic Surgery
Moh's Surgery
Surgery, Mohs Micrographic
Surgery, Mohs'
Surgery, Moh's Micrographic
Micrographic Surgery, Moh's
Micrographic Surgery, Mohs
Mohs Micrographic Surgery

A surgical technique used primarily in the treatment of skin neoplasms, especially basal cell or squamous cell carcinoma of the skin. This procedure is a microscopically controlled excision of cutaneous tumors either after fixation in vivo or after freezing the tissue. Serial examinations of fresh tissue specimens are most frequently done.


Connective Tissue Neoplasms
Neoplasms, Connective Tissue

Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.


Foot Ulcer, Diabetic
Diabetic Foot
Diabetic Feet

Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.


Pyridine derivatives with one or more keto groups on the ring.


Compounds based on an 8-membered heterocyclic ring including an oxygen. They can be considered medium ring ethers.


Fusion Regulatory Protein 1, Light Chains

A family of light chains that bind to FUSION REGULATORY PROTEIN 1, HEAVY CHAIN to form a heterodimer. They convey functional specificity to the protein.


Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.


Metalloceramic Alloys
Metallo-Ceramic Alloy
Metalloceramic Alloy
Metal Ceramic Alloys
Metal Ceramic Restorations
Metallo-Ceramic Alloys
Porcelain-Metal Alloys
Metal Ceramic Alloy

The fusion of ceramics (porcelain) to an alloy of two or more metals for use in restorative and prosthodontic dentistry. Examples of metal alloys employed include cobalt-chromium, gold-palladium, gold-platinum-palladium, and nickel-based alloys.


Carbon-13 Magnetic Resonance Spectroscopy

Magnetic resonance spectroscopy involving detection of changes in the resonance of carbon-13 nuclei in organic molecules.


Critical Period, Psychological
Critical Period, Psychology

A specific stage in animal and human development during which certain types of behavior normally are shaped and molded for life.


Oils high in unsaturated fats extracted from the bodies of fish or fish parts, especially the LIVER. Those from the liver are usually high in VITAMIN A. The oils are used as DIETARY SUPPLEMENTS. They are also used in soaps and detergents and as protective coatings.


Intubation, Endotracheal
Intubation, Intratracheal

A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.


Paranasal Sinuses
Sinonasal Tract
Nasal Sinuses

Air-filled spaces located within the bones around the NASAL CAVITY. They are extensions of the nasal cavity and lined by the ciliated NASAL MUCOSA. Each sinus is named for the cranial bone in which it is located, such as the ETHMOID SINUS; the FRONTAL SINUS; the MAXILLARY SINUS; and the SPHENOID SINUS.


Anthropology, Medical
Medical Anthropology

Field of social science that is concerned with differences between human groups as related to health status and beliefs.


Killer Cells, Natural
Natural Killer Cells
NK Cells

Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.


A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.


Admitting Department
Hospital Admissions Office
Hospital Admitting Department
Admitting Department, Hospital

Hospital department responsible for the flow of patients and the processing of admissions, discharges, transfers, and also most procedures to be carried out in the event of a patient's death.


Carbonyl Cyanide p Trifluoromethoxyphenylhydrazone

A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.


Occupational Medicine
Medicine, Occupational
Medicine, Industrial
Industrial Medicine

Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.


Enhancement, Biomedical
Enhancement Technologies
Biomedical Enhancement

The use of technology-based interventions to improve functional capacities rather than to treat disease.


Adenosine Aminohydrolase
Adenosine Deaminase

An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.


Cyclic Adenosine Diphosphate Ribose
Cyclic ADPribose
cADP-Ribose
Adenosine Diphosphate Ribose, Cyclic
Cyclic ADP-Ribose
cADPR

A pyridine nucleotide that mobilizes CALCIUM. It is synthesized from nicotinamide adenine dinucleotide (NAD) by ADP RIBOSE CYCLASE.


Water Channel Proteins
Water Channels
Aquaporins

A class of porins that allow the passage of WATER and other small molecules across CELL MEMBRANES.


Antithrombin III-Alpha
Kybernin
Antithrombin III
Heparin Co-Factor I
Atenativ
Thrombate III
Heparin Cofactor I
Serpin C1

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.


Education Research, Nursing
Nursing Research, Educational
Nursing Education Research
Research, Nursing Education
Research, Educational Nursing
Educational Nursing Research

Investigations into the problems of integrating research findings into nursing curricula, developing problem solving skills, finding approaches to clinical teaching, determining the level of practice by graduates from different basic preparations, etc.


Thy-1 Antigens
Antigens, CD90
Thy-1 Antigen
Antigens, Thy-1
CD90 Antigens
CD90 Antigen
Thy-1.1 Antigen
Thy-1.2 Antigen

A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.


Tumor-Infiltrating Lymphocytes
Lymphocytes, Tumor-Infiltrating
Tumor-Derived Activated Cells

Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into the patient, is one form of adoptive immunotherapy of cancer.


Pseudorabies Vaccines
Pseudorabies Vaccine

Vaccines or candidate vaccines used to prevent PSEUDORABIES (Aujeszky's disease), a herpesvirus of swine and other animals.


Inhospital Mortality
In Hospital Mortalities
Mortalities, Inhospital
Inhospital Mortalities
Hospital Mortalities
Hospital Mortality
In-Hospital Mortality
Mortality, Hospital
Mortality, Inhospital
Mortalities, In-house
Mortality, In-Hospital
In Hospital Mortality

A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.


Sports Psychology
Psychology, Sports
Sport Psychology

Field of research that studies mental factors influencing the attainment of athletic skills and athletic performance.


GUSB Deficiency
Sly Syndrome
Mucopolysaccharidosis Type VII
Mucopolysaccharidosis VII
Sly Disease
beta-Glucuronidase Deficiency
Mucopolysaccharidosis 7

Mucopolysaccharidosis characterized by excessive dermatan and heparan sulfates in the urine and Hurler-like features. It is caused by a deficiency of beta-glucuronidase.


A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.


Logical Observation Identifiers Names and Codes

A vocabulary database of universal identifiers for laboratory and clinical test results. Its purpose is to facilitate the exchange and pooling of results for clinical care, outcomes management, and research. It is produced by the Regenstrief Institute. (LOINC and RELMA [Internet]. Indianapolis: The Regenstrief Institute; c1995-2001 [cited 2002 Apr 2]. Available from http://www.regenstrief.org/loinc)


The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.


A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.


Bacteroides gingivalis
Porphyromonas gingivalis

A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.


Citrin Fruit
Mangostana cambogia
Garcinia cambogia

A plant species of the family CLUSIACEAE. It is a source of hydroxycitric acid.


Receptor, EphA8
EphA8 Receptor
EphA8 Protein
eph- and elk-Related Kinase
ELK-Related Kinase

An eph family receptor found exclusively in BRAIN. EphA8 receptors may play a role in the AXONAL GUIDANCE of a subset of tectal commissural NEURONS.


An order of aerobic, thermophilic archaea, in the kingdom EURYARCHAEOTA, characterized by the absence of a cell wall. Two genera have been described: THERMOPLASMA and Picrophilus.


Tachykinin Receptor
Tachykinin Receptors
Receptors, Tachykinin
Receptors, Tachykinins

Cell surface proteins that bind TACHYKININS with high affinity and trigger intracellular changes influencing the behavior of cells. Three classes of tachykinin receptors have been characterized, the NK-1; NK-2; and NK-3; which prefer, respectively, SUBSTANCE P; NEUROKININ A; and NEUROKININ B.


Gene Knock Down Techniques
Gene Knockdown
Gene Knockdown Techniques
Gene Knock-Down Techniques
Gene Knock-Down
Gene Knock Down

The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.


Compounds that contain a 1-dimethylaminonaphthalene-5-sulfonyl group.


Buscapine
Hyoscinbutylbromide
Hyoscine N-Butylbromide
Buscopan
Scopolan
Butylscopolammonium Bromide
Butylscopolamine
Buscolysin
N-Butylscopolammonium Bromide
Scopolaminebutylbromide

Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.


Cerebrospinal Fluid Pressure
Pressures, Cerebrospinal Fluid
Pressure, Cerebrospinal Fluid
Spinal Fluid Pressure
Cerebrospinal Fluid Pressures

Manometric pressure of the CEREBROSPINAL FLUID as measured by lumbar, cerebroventricular, or cisternal puncture. Within the cranial cavity it is called INTRACRANIAL PRESSURE.


Adenosine Triphosphatase, Hydrogen, Potassium

Hydrogen, Potassium, Adenosine Triphosphatase

An enzyme isolated from the GASTRIC MUCOSA that catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions across the cell wall. This enzyme was formerly listed as EC 3.6.1.36.


Posttranscriptional RNA Processing
RNA Processing, Post-Transcriptional
RNA Processing, Posttranscriptional
Post-Transcriptional RNA Modification
RNA Processing, Post Transcriptional
Post-Transcriptional RNA Processing

Post-transcriptional biological modification of messenger, transfer, or ribosomal RNAs or their precursors. It includes cleavage, methylation, thiolation, isopentenylation, pseudouridine formation, conformational changes, and association with ribosomal protein.


Oxyphenbutazone Oxyphenylbutazone Tanderil Hydroxyphenylbutazone Diflamil

A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)


A plant genus of the family GENTIANACEAE that contains nitiol (a C25 sesterterpenoid) & nitidasin.


Acetogenin Compounds
Acetogenins
Annonaceous Acetogenins

Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.


A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.


Point-of-Care Testing
Point of Care Testing
Bedside Testing

Allows patient diagnoses in the physician’s office, in other ambulatory setting or at bedside. The results of care are timely, and allow rapid treatment to the patient. (from NIH Fact Sheet Point-of-Care Diagnostic Testing, 2010.)


RNA, Transfer, Leu
Transfer RNA, Leu
Leucine-Specific tRNA
tRNA(Leu)
tRNALeu

A transfer RNA which is specific for carrying leucine to sites on the ribosomes in preparation for protein synthesis.


Microbeads
Latex Particles
Microspheres
Latex Beads
Latex Spheres

Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.


Serological tumor marker composed of a molecular complex of cytokeratins 8, 18, and 19. It is used in the diagnosis and staging of bronchogenic carcinoma.


Contraceptive Agents, Hormonal
Contraceptive Agents, Male Hormonal
Contraceptive Agents, Female Hormonal
Hormonal Contraceptive Agents

Contraceptive agents that act on the ENDOCRINE SYSTEM.


CD30-Positive Anaplastic Large-Cell Lymphoma

A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.


Lower Extremity
Membrum inferius
Lower Limb
Extremity, Lower

The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.


Environmental Protection Agency, United States

United States Environmental Protection Agency

An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.


A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.


Isocitratase
Isocitrase
Isocitrate Lyase

A key enzyme in the glyoxylate cycle. It catalyzes the conversion of isocitrate to succinate and glyoxylate. EC 4.1.3.1.


A plant genus of the family Lamiaceae. Members contain clerodane DITERPENES and callicarpone.


Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein

A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.


Pemoline
Pemoline Compounds
Cylert
Phenoxazole
Phenylisohydantoin
Pemoline Magnesium
PemADD
Tradon

A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.


Persistent Common Atrioventricular Canal

A spectrum of septal defects involving the ATRIAL SEPTUM; VENTRICULAR SEPTUM; and the atrioventricular valves (TRICUSPID VALVE; BICUSPID VALVE). These defects are due to incomplete growth and fusion of the ENDOCARDIAL CUSHIONS which are important in the formation of two atrioventricular canals, site of future atrioventricular valves.


A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.


FEVt
Forced Expiratory Volume
Forced Vital Capacity, Timed
Timed Vital Capacity
Vital Capacity, Timed

Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.


Immunosorbent Techniques
Immunoadsorbent Technics
Immunosorbent Technics
Immunoadsorbent Techniques

Techniques for removal by adsorption and subsequent elution of a specific antibody or antigen using an immunosorbent containing the homologous antigen or antibody.


Pulmonary Infarction
Infarction, Pulmonary
Pulmonary Infarct

NECROSIS of lung tissue that is cause by the lack of OXYGEN or blood supply. The most common cause of pulmonary infarction is a blood clot in the lung.


A tri-benzene-ammonium usually compounded with zinc chloride. It is used as a biological stain and for the dyeing and printing of textiles.


Early Growth Response Transcription Factor 1

An early growth response transcription factor and zinc finger protein that has been implicated in regulation of CELL PROLIFERATION and APOPTOSIS.


Optic Atrophy, Hereditary
Optic Atrophies, Hereditary
Hereditary Optic Atrophy

Hereditary conditions that feature progressive visual loss in association with optic atrophy. Relatively common forms include autosomal dominant optic atrophy (OPTIC ATROPHY, AUTOSOMAL DOMINANT) and Leber hereditary optic atrophy (OPTIC ATROPHY, HEREDITARY, LEBER).


Phenylmercuric Acetate
Falisan-Nassbeize
Acetoxyphenylmercury
Verdasan

A phenyl mercury compound used mainly as a fungicide. Has also been used as a herbicide, slimicide, and bacteriocide.


Autoimmune Chronic Hepatitis
Hepatitis, Autoimmune
Autoimmune Hepatitis

A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.


Perazine Maleate (1:1)
Taxilan
Perazine Dihydrochloride
Perazine
Perazine Maleate (1:2)
Perazine Maleate
Pernazine

A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects.


Penicillin, Aminobenzyl
Ukapen
Pentrexyl
Omnipen
Ampicillin
Ampicillin Trihydrate
Aminobenzylpenicillin
Ampicillin Sodium
Polycillin
Amcill
Antibiotic KS-R1

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.


Services, Personal Health
Personal Health Services
Health Services, Personal


Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.


Fluorhydric Acid
Hydrogen Fluoride
Hydrofluoric Acid
Fluohydric Acid

Hydrofluoric acid. A solution of hydrogen fluoride in water. It is a colorless fuming liquid which can cause painful burns.


Tooth Abnormalities
Odontome
Abnormalities, Teeth
Teeth Abnormalities
Abnormalities, Tooth

Congenital absence of or defects in structures of the teeth.


X-ray Repair Cross Complementing Protein 1

A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.


Vaccine-Preventable Diseases
Vaccine Preventable Diseases

Diseases for which vaccines exist that can confer partial or complete protection. (World Health Organization vaccine-safety-training.org)


TGA (Transient Global Amnesia)
Transient Global Amnesia
Amnesia, Transient Global

A syndrome characterized by a transient loss of the ability to form new memories. It primarily occurs in middle aged or elderly individuals, and episodes may last from minutes to hours. During the period of amnesia, immediate and recent memory abilities are impaired, but the level of consciousness and ability to perform other intellectual tasks are preserved. The condition is related to bilateral dysfunction of the medial portions of each TEMPORAL LOBE. Complete recovery normally occurs, and recurrences are unusual. (From Adams et al., Principles of Neurology, 6th ed, pp429-30)


Liver Diseases, Parasitic
Parasitic Liver Diseases

Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).


Genes, Immunoglobulin Light Chain
Immunoglobulin Light Chain Genes
Ig Light Chain Genes

Genes and gene segments encoding the IMMUNOGLOBULIN LIGHT CHAINS. Gene segments of the light chain genes are designated as V (variable), J (joining), and C (constant).


alpha2 Heremans-Schmid Glycoprotein
alpha2HS Glycoprotein
Fetuin-A
alpha-2-HS-Glycoprotein
alpha(2) HS Glycoprotein
alpha-2HS Glycoprotein
AHSG Protein

A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.


Butyryl-Coenzyme A Dehydrogenase
Butyryl-CoA Dehydrogenase
Short-Chain Acyl-CoA Dehydrogenase
Butyryl Dehydrogenase

A flavoprotein oxidoreductase that has specificity for short-chain fatty acids. It forms a complex with ELECTRON-TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE.


NPH Insulin
Insulin, Isophane
Isophane Insulin, Regular
Insulin, NPH
Insulin, Protamine Zinc
Protamine Hagedorn Insulin
Neutral Protamine Hagedorn Insulin

An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.


Transport, Biological
Biological Transport
Biologic Transport

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.


Poly-ADP-Ribose Binding Motifs
pADPr-Binding Motifs
Poly-ADP Ribose Binding Modules
pADPr-Binding Motif
Poly-ADP Ribose Binding Module
Poly-ADP-Ribose Binding Motif

A protein motif 22 to 26 amino acids in length that binds POLY(ADP RIBOSE) polymers through non-covalent interactions. It is characterized by basic and hydrophobic residues that frequently include ALANINE; VALINE; ISOLEUCINE; or LEUCINE and flank LYSINE and ARGININE amino acids.


Very Late Activation Antigen-4
alpha4beta1 Integrin
Very Late Antigen-4
Integrin Heterodimer alpha4beta1
Integrin alpha4beta1
CD49d-CD29
VLA-4
Integrin alpha(4)beta(1)

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.


Nonsense Mediated mRNA Decay
Nonsense-Mediated mRNA Decay

An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.


Diabetes Mellitus, Gestational
Diabetes, Gestational
Diabetes, Pregnancy-Induced
Gestational Diabetes

Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.


Translocation, Bacterial
Bacterial Translocation

The passage of viable bacteria from the GASTROINTESTINAL TRACT to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the INTESTINAL MUCOSA resulting in increased intestinal permeability. Bacterial translocation from the lung to the circulation is also possible and sometimes accompanies MECHANICAL VENTILATION.


Melanocortin Receptor 1
Receptor, Melanocortin, Type 1
MC1 Receptor
Melanocyte Melanocortin Receptor
Melanocortin-1 Receptor
Receptor, Melanocortin-1

A melanocortin receptor subtype found primarily in MELANOCYTES. It shows specificity for ALPHA-MSH and ADRENOCORTICOTROPIC HORMONE. Loss of function mutations of the type 1 melanocortin receptor account for the majority of red hair and fair skin recessive traits in human.


Subcutaneous Fat, Abdominal
Abdominal Subcutaneous Adipose Tissue
Fat, Abdominal Subcutaneous
Adipose Tissue, Abdominal Subcutaneous
Abdominal Subcutaneous Fat

Fatty tissue under the SKIN in the region of the ABDOMEN.


Progestin Synthesis Inhibitors
Sex Hormone Synthesis Inhibitors
Glucocorticoid Synthesis Inhibitors
Estrogen Synthesis Inhibitors
Steroid Synthesis Antagonists
Mineralocorticoid Synthesis Inhibitors
Steroid Synthesis Inhibitors
Androgen Synthesis Inhibitors
Adrenal Steroid Synthesis Inhibitors
Steroid Synthesis Blockers

Compounds that bind to and inhibit enzymes involved in the synthesis of STEROIDS.


United Nations Educational, Scientific and Cultural Organization

An operating body of the UNITED NATIONS, responsible for coordinating international cooperation in education, science, culture and communication.


Prescriptive Counseling
Directive Counseling

Counseling during which a professional plays an active role in a client's or patient's decision making by offering advice, guidance, and/or recommendations.


Marijuana Treatment
Medicinal Cannabis
Marijuana Dispensaries
Medicinal Marijuana
Medical Cannabis
Medical Marijuana

Product of the CANNABIS plant, CANNABINOIDS, or synthetic derivatives thereof, used in the treatment of a wide range of clinical symptoms.


A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.


Pabp2 Gene Product
PAB II
Poly(A)-Binding Protein II
Pabp2 Protein
PABP2
PAB2 Poly(A) Binding Protein
Poly(A) Binding Protein, Nuclear 1
Poly(A) Binding Protein II

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.


Leukemia Virus, Gibbon Ape
GALV
Gibbon ape leukemia virus

A species of GAMMARETROVIRUS causing leukemia in the gibbon ape. Natural transmission is by contact.


Prevotella intermedia
Bacteroides intermedius

A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium is a common commensal in the gingival crevice and is often isolated from cases of gingivitis and other purulent lesions related to the mouth.


Child Health
Childrens Health
Children's Health

The concept covering the physical and mental conditions of CHILDREN.


Bromothymol Blue
Bromthymol Blue
Dibromothymolsulfonphthalein

A pH sensitive dye that has been used as an indicator in many laboratory reactions.


Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid.


A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.


A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.


A phylum of acoelomate, bilaterally symmetrical flatworms, without a definite anus. It includes three classes: Cestoda, Turbellaria, and Trematoda.


Alveolodental Membrane
Alveolodental Ligament
Periodontal Ligament
Gomphosis

The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).


Silorane System Adhesive
Silorane Resins
Siloranes

Polymeric resins containing a combination of SILOXANES and OXIRANES.


Micro Liquid-Liquid Extraction
Liquid-Liquid Microextraction
Micro Liquid Phase Extraction
Liquid Phase Microextraction

Miniaturized methods of liquid-liquid extraction.


pPTB
PTB Splicing Factor
PTB Protein
p57 Cytoplasmic RNA-Binding Protein
Polypyrimidine Tract-Binding Protein

A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.


Paget Disease, Extra-Mammary
Extramammary Paget's Disease
Paget's Disease, Extramammary
Paget's Disease, Extra-Mammary
Paget Disease, Extramammary
Extra-Mammary Paget Disease
Extra-Mammary Paget's Disease
Extramammary Paget Disease
Paget Disease Extramammary

A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)


Insulin-Like Somatomedin Peptide II
Somatomedin MSA
Multiplication-Stimulating Activity
Somatomedin A
IGF-2
Multiplication-Stimulating Factor
Insulin-Like Growth Factor II
IGF-II
Insulin Like Growth Factor II

A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.


Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)


Ascaroidea Baylisascaris Ascaridoidea Parascaris

A superfamily of polymyarian nematode worms. An important characteristic of this group is the presence of three prominent lips around the mouth of the organism.


Oxidized LDL Receptor
Ox-LDL Receptor
Receptor, Oxidized LDL
Receptor, LDL, Oxidized
Oxidized LDL Receptors
Receptors, Oxidized LDL

A group of cell-surface receptors for oxidatively modified LOW-DENSITY LIPOPROTEINS. The group includes certain SCAVENGER RECEPTORS that contribute to the pathogenesis of ATHEROSCLEROSIS by uptake of oxidized LDL.


Petroleum Pollution
Oil Pollution
Oil Spills

Release of oil into the environment usually due to human activity.


A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells.


The protein complement of an organism coded for by its genome.


Antigens, CDW210B
Interleukin-10 Receptor, beta Chain
Interleukin-10 Receptor beta Subunit
CDW210B Antigen
Interleukin-10 Receptor 2
CDW210B Antigens

A subunit of the interleukin-10 receptor. It plays a role in receptor signaling by associating with TYK2 KINASE.


Headache, Migraine
Migraine Variant
Hemicrania Migraine
Migraine
Abdominal Migraine
Status Migrainosus
Sick Headache
Migraine Headache
Acute Confusional Migraine
Migraine Disorders
Cervical Migraine Syndrome

A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)


Carriers, Genetic, Detection
Heterozygote Screening
Genetic Carrier Screening
Carrier Detection, Genetic
Genetic Carriers, Detection
Heterozygote Detection
Detection, Genetic Carrier
Genetic Carrier Detection

Identification of individuals who are heterozygous at a GENETIC LOCUS for a recessive PHENOTYPE.


Emergency Treatment
Therapy, Emergency
Emergency Therapy

First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.


Transcription Factor E2F-6
E2F6 Transcription Factor
E2F Transcription Factor 6 Protein

An E2F transcription factor that represses GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F6 recruits chromatin remodeling factors directly to target gene promoters and lacks the transactivation domain responsible for binding to the retinoblastoma family of tumor suppressors.


Labor Complications
Complications, Labor
Obstetric Labor Complications

Medical problems associated with OBSTETRIC LABOR, such as BREECH PRESENTATION; PREMATURE OBSTETRIC LABOR; HEMORRHAGE; or others. These complications can affect the well-being of the mother, the FETUS, or both.


Mites, Storage
Acaridae
Storage Mites
Mites, Store Product

Family of MITES, in the superfamily Acaroidea, order Astigmata. They are frequently found in cereal-based foodstuffs including GRAIN and FLOUR.


A subclass of cartilaginous fish comprising the SHARKS; rays; skates (SKATES (FISH);), and sawfish. Elasmobranchs are typically predaceous, relying more on smell (the olfactory capsules are relatively large) than sight (the eyes are relatively small) for obtaining their food.


Bundles of actin filaments (ACTIN CYTOSKELETON) and myosin-II that span across the cell attaching to the cell membrane at FOCAL ADHESIONS and to the network of INTERMEDIATE FILAMENTS that surrounds the nucleus.


LDH-A4
LDH-A
LDH-M4
M4-LDH
Lactate Dehydrogenase 5
Lactate Dehydrogenase-M
Lactate Dehydrogenase A
LDH 5
LDH-M

A member of the LACTATE DEHYDROGENASES isozyme family, Lactate Dehydrogenase 5 is localized to liver and skeletal muscle cells where its expression increases in liver disease and striated muscle trauma respectively.


A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.


Sensitivity, Multiple Chemical
Chemical Sensitivity, Multiple
Sensitivities, Multiple Chemical
Idiopathic Environmental Intolerances
Multiple Chemical Sensitivity Syndrome
Chemical Sensitivities, Multiple
Multiple Chemical Sensitivities
Multiple Chemical Sensitivity
Idiopathic Environmental Intolerance

An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)


A bone that forms the lower and anterior part of each side of the hip bone.


Vaccines, DNA
Vaccines, Recombinant DNA
Recombinant DNA Vaccines
Nucleic Acid Vaccines
DNA Vaccines
Naked DNA Vaccines
Polynucleotide Vaccines

Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.


Hepatocyte Growth Factor
Scatter Factor
Hepatopoietin A
Hepatopoietin

Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.


STLV-1
T-Lymphotropic Virus, Type I, Simian
Simian T Lymphotropic Virus Type I
T Lymphotropic Virus, Type I, Simian
Simian T-lymphotropic virus 1
STLV-I
Simian T-Lymphotropic Virus Type I

A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2, closely related to the human HTLV-1 virus. The clinical, hematological, and histopathological characteristics of the disease in STLV-infected monkeys are very similar to those of human adult T-cell leukemia. Subgroups include the African green monkey subtype (STLV-I-AGM), for which the nucleotide sequence is 95% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1, and the Asian rhesus macaque subtype (STLV-I-MM), for which the nucleotide sequence is 90% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1.


A specialty in which manual or operative procedures are used in the treatment of disease, injuries, or deformities.


Cardioplegic Solutions
Cardioplegic Solution

Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.


Classical loci in ACUPUNCTURE. They are main and collateral channels, regarded as a network of passages, through which vital energy (Qi) circulates and along which acupoints (ACUPUNCTURE POINTS) are distributed. The meridians are a series of 14 lines upon which more than 400 acupoints are located on the body. (The Pinyin Chinese-English Dictionary, p. 359; Dr. Wu Lancheng, Academy of Traditional Chinese Medicine, Beijing)


Stromal Interaction Molecule 2
STIM2 Protein

A stromal interaction molecule that functions as a highly sensitive calcium sensor in the ENDOPLAMSIC RETICULUM and CYTOSOL. It can regulate CALCIUM RELEASE ACTIVATED CALCIUM CHANNELS in response to minor variations in intracellular calcium.


Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.


Cell Number Growth
Cell Growth in Number
Cell Multiplication
Cell Proliferation
Cellular Proliferation

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.


A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-23 is comprised of a unique 19 kDa subunit and 40 kDa subunit that is shared with INTERLEUKIN-12. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells


Hepatitis C Antibodies
Anti-HCV Antibodies
Anti-Hepatitis C Virus Antibodies
Hepatitis C Virus Antibodies
HCV Antibodies

Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.


Receptors, Androgen
Stanolone Receptor
5 alpha-Dihydrotestosterone Receptor
Receptors, Dihydrotestosterone
Dihydrotestosterone Receptors
Receptor, Testosterone
Testosterone Receptor
Androgen Receptors
Androgen Receptor
Receptors, Androgens
Receptors, Stanolone

Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.


Gated Equilibrium Blood-Pool Scintigraphy

Gated Equilibrium Blood Pool Scintigraphy

Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).


Animals kept by humans for companionship and enjoyment, as opposed to DOMESTIC ANIMALS such as livestock or farm animals, which are kept for economic reasons.


Mentha is a genus of the mint family (LAMIACEAE). It is known for species having characteristic flavor and aroma.


GABA Antagonists
GABA Receptor Antagonists
GABA Antagonist
gamma-Aminobutyric Acid Antagonists

Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS.


Glycine Decarboxylase Complex
Glycine Cleavage System Complex

A enzyme complex that catalyzes the oxidative DECARBOXYLATION and DEAMINATION of GLYCINE into CARBON DIOXIDE; AMMONIA; NADH; and N5N10-methylenetetrahydrofolate. It is composed of four different component protein components referred to as H, P, L, and T.


Pontiac Fever
Legionella pneumophila Infections
Legionnaire Disease
Infections, Legionella pneumophila
Legionnaires' Disease

An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.


20-carbon saturated monocarboxylic acids.


Trypanosoma brucei rhodesiense
Trypanosoma rhodesiense

A hemoflagellate subspecies of parasitic protozoa that causes Rhodesian sleeping sickness in humans. It is carried by Glossina pallidipes, G. morsitans and occasionally other species of game-attacking tsetse flies.


Works about discussions, descriptions or catalogs of public displays or items representative of a given subject.


Asystole
Heart Arrest
Cardiopulmonary Arrest
Cardiac Arrest

Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.


Oral Contraceptives
Oral Contraceptives, Phasic
Oral Contraceptives, Low-Dose
Contraceptives, Oral

Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.


TCF-3 Transcription Factor
Transcription Factor 7-Like 1 Protein
T Cell Factor 3
HMG Box Transcription Factor 3
TCF7L1 Transcription Factor

A transcription factor that takes part in WNT signaling pathway where it may play a role in the differentiation of KERATINOCYTES. The transcriptional activity of this protein is regulated via its interaction with BETA CATENIN.


Methylcellulose
Citrucel
Methocel
Cologel
Dacryolarmes
Muciplasma
Celevac
BFL
Methyl Cellulose
Cellothyl
Cellulone

Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.


Outer Membrane Proteins, Bacterial
OMP Proteins
Outer Membrane Lipoproteins, Bacterial
Bacterial Outer Membrane Proteins

Proteins isolated from the outer membrane of Gram-negative bacteria.


Miosis, Persistent
Miosis
Constricted Pupil
Pupillary Miosis
Small Pupil

Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.


An HMG-box domain (HMG-BOX DOMAINS) found highly expressed in embryonic tissue and in placenta.


Alloy, Dental
Dental Alloy
Dental Alloys
Alloys, Dental

A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions for use in restorative or prosthetic dentistry.


Dammarane type triterpene saponins based mainly on the aglycones, protopanaxadiol and protopanaxatriol.


Gingival Hemorrhage
Hemorrhage, Gingival

The flowing of blood from the marginal gingival area, particularly the sulcus, seen in such conditions as GINGIVITIS, marginal PERIODONTITIS, injury, and ASCORBIC ACID DEFICIENCY.


Metalloproteinase Elastase
Macrophage-Specific Metalloelastase
Macrophage Metalloelastase
MMP-12 Metalloproteinase
Matrix Metalloproteinase 12
MMP12 Metalloproteinase

A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.


Olivary Nucleus
Nucleus Basalis, Olivary
Basal Nucleus, Olivary

A part of the MEDULLA OBLONGATA situated in the olivary body. It is involved with motor control and is a major source of sensory input to the CEREBELLUM.


CC Chemokine Receptors
CCR Receptors
CC Chemokine Receptor
Chemokine (C-C Motif) Receptors
Receptors, CCR

Chemokine receptors that are specific for CC CHEMOKINES.


Safrol 4-Allyl-1,2-methylenedioxybenzene Safrole Shikimol

A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).


Intravenous Hyperalimentation
Total Parenteral Nutrition
Parenteral Nutrition, Total
Nutrition, Total Parenteral
Hyperalimentation, Parenteral
Parenteral Hyperalimentation

The delivery of nutrients for assimilation and utilization by a patient whose sole source of nutrients is via solutions administered intravenously, subcutaneously, or by some other non-alimentary route. The basic components of TPN solutions are protein hydrolysates or free amino acid mixtures, monosaccharides, and electrolytes. Components are selected for their ability to reverse catabolism, promote anabolism, and build structural proteins.


5-Hydroxy-3-Indoleacetic Acid
5-Hydroxyindolamine Acetic Acid
Hydroxyindoleacetic Acid
5-HIAA


GMO Food
Food, Genetically Modified
Genetically Modified Food

Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).


Ampholyte Mixtures
Carrier Ampholytes
Ampholines
Isoelectric Focusing Agents

Such mixtures of amphoteric electrolytes or buffers that provide a continuous range of pH in an electric field; used for separating proteins by their isoelectric points, i.e., by isoelectric focusing.


Glycylglycine
Glycylglycine Hydrochloride
N-Glycylglycine
Glycylglycine Monohydrochloride
Diglycine
Glycyl-Glycine

The simplest of all peptides. It functions as a gamma-glutamyl acceptor.


A tetraspanin domain-containing uroplakin subtype. It heterodimerizes with UROPLAKIN II to form a component of the asymmetric unit membrane found in urothelial cells.


Rhytidectomy
Facelift
Rhytidoplasty
Platysmotomy
Face Lift
Platysmaplasty

Plastic surgery performed, usually by excision of skin, for the elimination of wrinkles from the skin.


A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.


Phenylethanolamine N-Methyltransferase
Norepinephrine N-Methyltransferase
Noradrenalin N-Methyltransferase
Norepinephrine Methyltransferase
Noradrenaline N-Methyltransferase
Phenethanolamine N-Methyltransferase

A methyltransferase that catalyzes the reaction of S-adenosyl-L-methionine and phenylethanolamine to yield S-adenosyl-L-homocysteine and N-methylphenylethanolamine. It can act on various phenylethanolamines and converts norepinephrine into epinephrine. (From Enzyme Nomenclature, 1992) EC 2.1.1.28.


Protein S
Vitamin K-Dependent Protein S
Cofactor Protein S
Protein S, Vitamin K-Dependent

The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.


Minichromosome Maintenance Complex Component 4

A minichromosome maintenance protein that is a key component of the six member MCM protein complex. It is also found in tightly-bound trimeric complex with MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 6 and MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 7.


The meaning ascribed to the BASE SEQUENCE with respect to how it is translated into AMINO ACID SEQUENCE. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons (CODON).


A plant genus in the family PAPAVERACEAE, order Papaverales, subclass Magnoliidae.


Databases, Factual
Data Bases, Factual
Data Banks, Factual
Databanks, Factual

Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.


Dating Violence
Intimate Partner Violence
Intimate Partner Abuse

A pattern of assaultive and coercive behavior by an individual against their partner or spouse that may include physical injury, psychological abuse, sexual assault, progressive isolation, stalking, deprivation, intimidation, and reproductive coercion.


Pregneninolone
Anhydrohydroxyprogesterone
17 alpha-Ethynyltestosterone
Ethisterone

17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.


Tissue Inhibitor of Metalloproteinases
TIMP Proteins

A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.


Lysophagy
Macroautophagy
Xenophagy
Macro-Autophagy
Aggrephagy
Pexophagy
Chaperone-Assisted-Selective Autophagy
Proteaphagy

Autophagic degradation of microorganisms in the CYTOPLASM.


Mucins that are found on the surface of the gastric epithelium. They play a role in protecting the epithelial layer from mechanical and chemical damage.


Cortical Amygdalar Nucleus
Periamygdaloid Area
Periamygdaloid Cortex

The surface of the parahippocampal gyrus overlying the cortical amygdaloid nucleus.


HLA Class II Histocompatibility Antigen, DR alpha Chain

Transmembrane proteins that form the alpha subunits of the HLA-DR antigens. They are also referred to as the HLA-DR heavy chains.


Opiate Alkaloids
Opiates
Opiates, Alkaloid

Alkaloids found in OPIUM from PAPAVER and their derivatives that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS.


Immunoglobulin mu-Chain
Immunoglobulin mu-Chains
mu Immunoglobulin Heavy Chains
Ig mu Chains
mu-Chain Immunoglobulins
Immunoglobulins, mu-Chain
mu Immunoglobulin Heavy Chain

The class of heavy chains found in IMMUNOGLOBULIN M. They have a molecular weight of approximately 72 kDa and they contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IMMUNOGLOBULIN G.


Dane Particle
Hepatitis Virus, Homologous Serum
Hepatitis B virus

The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.


A viral disease infecting PRIMATES and RODENTS. Its clinical presentation in humans is similar to SMALLPOX including FEVER; HEADACHE; COUGH; and a painful RASH. It is caused by MONKEYPOX VIRUS and is usually transmitted to humans through BITES or via contact with an animal's BLOOD. Interhuman transmission is relatively low (significantly less than smallpox).


Death Domain Superfamily
Death-Like Domain
Death-Like Domains

A family of structurally-related protein interaction domains characterized by 6-helical closed bundle fold, with Greek key topology and an internal pseudo two-fold symmetry. Death-like domains occur in many proteins that are essential for APOPTOSIS, including CASPASE RECRUITMENT DOMAIN CONTAINING PROTEINS and DEATH DOMAIN RECEPTORS.


Cytidine 5'-Monophosphosialic Acid Synthetase

An enzyme that forms CMP-acylneuraminic acids, which donate the N-acylneuraminic acid residues to the terminal sugar residue of a ganglioside or glycoprotein. EC 2.7.7.43.


Multiple Psychotherapy
Psychotherapy, Multiple

The use of more than one therapist at one time in individual or group psychotherapy.


Odor Receptor Protein
Odorant Receptor
Odorant Receptors
Olfactory Receptor
Receptors, Odorant
Olfactory Receptors
Olfactory Receptor Proteins
Olfactory Receptor Protein
Receptor Proteins, Odorant
Receptor Proteins, Olfactory

Proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the neurons. The large number of different odorant receptors appears to arise from several gene families or subfamilies rather than from DNA rearrangement.


Women, Pregnant
Pregnant Woman
Pregnant Women

Human females who are pregnant, as cultural, psychological, or sociological entities.


Inactivation of viruses by non-immune related techniques. They include extremes of pH, HEAT treatment, ultraviolet radiation, IONIZING RADIATION; DESICCATION; ANTISEPTICS; DISINFECTANTS; organic solvents, and DETERGENTS.


Prescription Drug Diversion
Controlled Substance Diversion

The transfer of prescription drugs from legal to illegal distribution and marketing networks.


Liquid Ventilation
Partial Liquid Ventilation
Fluorocarbon Ventilation
Total Liquid Ventilation
Liquid Assisted Ventilation

Artificial respiration (RESPIRATION, ARTIFICIAL) using an oxygenated fluid.


Cyclic Nucleotide Phosphodiesterases, Type 7B

Cyclic Nucleotide Phosphodiesterase PDE7 Family

Cyclic Nucleotide Phosphodiesterases, Type 7A

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own tissue localization. The isoforms are encoded by at least two genes and are a product of multiple alternative splicing of their mRNAs.


Bleeding from the vessels of the retina.


Stokes-Adams Attacks
Adam-Stokes Attacks
Stokes-Adams Syndrome
Adams-Stokes Syndrome

A condition of fainting spells caused by heart block, often an atrioventricular block, that leads to BRADYCARDIA and drop in CARDIAC OUTPUT. When the cardiac output becomes too low, the patient faints (SYNCOPE). In some cases, the syncope attacks are transient and in others cases repetitive and persistent.


A type of irritant dermatitis localized to the area in contact with a diaper and occurring most often as a reaction to prolonged contact with urine, feces, or retained soap or detergent.


An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.


Heart Disorders
Cardiac Disorders
Heart Diseases
Cardiac Diseases

Pathological conditions involving the HEART including its structural and functional abnormalities.


A cyclin subtype that is transported into the CELL NUCLEUS at the end of the G2 PHASE. It stimulates the G2/M phase transition by activating CDC2 PROTEIN KINASE.


Influenza A Virus, H5N2 Subtype
H5N2 Virus

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 2. The H5N2 subtype has been found to be highly pathogenic in chickens.


Microbiology, Environmental
Environmental Microbiology

The study of microorganisms living in a variety of environments (air, soil, water, etc.) and their pathogenic relationship to other organisms including man.


The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.


WR-246310
Hematoporphyrin Derivative
Photofrin I
Hematoporphyrin D
Hematoporphyrin YHPD

A complex mixture of monomeric and aggregated porphyrins used in the photodynamic therapy of tumors (HEMATOPORPHYRIN PHOTORADIATION). A purified component of this mixture is known as DIHEMATOPORPHYRIN ETHER.


Autophagic Programmed Cell Death
Programmed Cell Death, Type II
Autophagy-Dependent Cell Death
Autophagic Cell Death

A major activation of the autophagic pathway, characterized by massive accumulation of AUTOPHAGOSOMES and CELL DEATH.


Paraperiodic Acid
Periodic Acids
Periodic Acid (HIO4)
Periodic Acid


Fatty Acid Elongases
Fatty Acid Elongation Enzyme
ELOVL Proteins

Enzymes conserved from yeast to mammals which mediate elongation of FATTY ACIDS into very-long-chain fatty acids.


Transgenesis
Gene Delivery Systems
Gene Transfer Techniques
Gene Transfer Technique

The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.


Solute Carrier Family 2, Facilitated Glucose Transporter, Member 4 Protein

A glucose transport protein found in mature MUSCLE CELLS and ADIPOCYTES. It promotes transport of glucose from the BLOOD into target TISSUES. The inactive form of the protein is localized in CYTOPLASMIC VESICLES. In response to INSULIN, it is translocated to the PLASMA MEMBRANE where it facilitates glucose uptake.


Anoctamins
Anoctamin
TMEM16 Protein Family
TMEM16 Proteins

A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.