The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]


regulation of Rho guanine nucleotide exchange factor

regulation of Rho guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. [GOC:obol]


negative regulation of Rho guanine nucleotide exchange factor

negative regulation of Rho guanyl-nucleotide exchange factor activity

Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. [GOC:obol]


positive regulation of Rho guanine nucleotide exchange factor

positive regulation of Rho guanyl-nucleotide exchange factor activity

Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. [GOC:obol]


regulation of lens epithelial cell proliferation

Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation. [GOC:obol]


negative regulation of lens epithelial cell proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation. [GOC:obol]


positive regulation of lens epithelial cell proliferation

Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation. [GOC:obol]


regulation of cellular response to HGF stimulus

regulation of cellular response to hepatocyte growth factor stimulus

Any process that modulates the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. [GOC:obol]


negative regulation of cellular response to HGF stimulus

negative regulation of cellular response to hepatocyte growth factor stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. [GOC:obol]


positive regulation of cellular response to HGF stimulus

positive regulation of cellular response to hepatocyte growth factor stimulus

Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. [GOC:obol]


methanopterin-containing compound metabolic process

The chemical reactions and pathways involving a methanopterin. [GOC:mengo_curators]


methanopterin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of a methanopterin. [GOC:mengo_curators]


The chemical reactions and pathways involving a tetrahydromethanopterin. [GOC:mengo_curators]


The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin. [GOC:mengo_curators]


The chemical reactions and pathways involving a methanofuran. [GOC:mengo_curators]


The chemical reactions and pathways resulting in the formation of a methanofuran. [GOC:mengo_curators]


coenzyme gamma-F420-2 biosynthetic process

The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2. [GOC:mengo_curators]


The chemical reactions and pathways involving a maltoheptaose. [GOC:mengo_curators]


The chemical reactions and pathways resulting in the breakdown of a maltoheptaose. [GOC:mengo_curators]


regulation of translational frameshifting

Any process that modulates the frequency, rate or extent of translational frameshifting. [GOC:obol]


negative regulation of translational frameshifting

Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting. [GOC:obol]


positive regulation of translational frameshifting

Any process that activates or increases the frequency, rate or extent of translational frameshifting. [GOC:obol]


methane biosynthetic process from formic acid

The chemical reactions and pathways resulting in the formation of a methane from a formic acid. [GOC:mengo_curators]


methane biosynthetic process from methylamine

The chemical reactions and pathways resulting in the formation of a methane from a methylamine. [GOC:mengo_curators]


methane biosynthetic process from dimethylamine

The chemical reactions and pathways resulting in the formation of a methane from a dimethylamine. [GOC:mengo_curators]


methane biosynthetic process from trimethylamine

The chemical reactions and pathways resulting in the formation of a methane from a trimethylamine. [GOC:mengo_curators]


methane biosynthetic process from dimethyl sulfide

The chemical reactions and pathways resulting in the formation of a methane from a dimethyl sulfide. [GOC:mengo_curators]


methane biosynthetic process from 3-(methylthio)propionic acid

The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid. [GOC:mengo_curators]


methane biosynthetic process from methanethiol

The chemical reactions and pathways resulting in the formation of a methane from a methanethiol. [GOC:mengo_curators]


methane biosynthetic process from carbon monoxide

The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide. [GOC:mengo_curators]


Any process that modulates the frequency, rate or extent of endocytic recycling. [GOC:obol]


regulation of retrograde transport of endocytic vesicles


negative regulation of endocytic recycling

Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling. [GOC:obol]


positive regulation of endocytic recycling

Any process that activates or increases the frequency, rate or extent of endocytic recycling. [GOC:obol]


positive regulation of retrograde transport of endocytic vesicles


Any process that modulates the frequency, rate or extent of phospholipid transport. [GOC:obol]


negative regulation of phospholipid transport

Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid transport. [GOC:obol]


positive regulation of phospholipid transport

Any process that activates or increases the frequency, rate or extent of phospholipid transport. [GOC:obol]


regulation of RNA synthesis
regulation of RNA biosynthesis
regulation of RNA formation
regulation of RNA anabolism

Any process that modulates the frequency, rate or extent of RNA biosynthetic process. [GOC:dph]


The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:obol]


The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:obol]


regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. [GOC:obol]


negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. [GOC:obol]


positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. [GOC:obol]


regulation of dipeptide membrane transport

regulation of dipeptide transmembrane transport

Any process that modulates the frequency, rate or extent of dipeptide transmembrane transport. [GOC:obol]


negative regulation of dipeptide membrane transport

negative regulation of dipeptide transmembrane transport

Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transmembrane transport. [GOC:obol]


positive regulation of dipeptide membrane transport

positive regulation of dipeptide transmembrane transport

Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport. [GOC:obol]


Any process that modulates the frequency, rate or extent of renal water transport. [GOC:obol]


negative regulation of renal water transport

Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport. [GOC:obol]


positive regulation of renal water transport

Any process that activates or increases the frequency, rate or extent of renal water transport. [GOC:obol]


regulation of glucose fermentation to ethanol

regulation of glycolytic fermentation to ethanol

Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol. [GOC:obol]


negative regulation of ethanol fermentation

negative regulation of glucose fermentation to ethanol

negative regulation of glycolytic fermentation to ethanol

Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol. [GOC:obol]


regulation of proline degradation to glutamate

regulation of proline breakdown to glutamate

regulation of proline catabolic process to glutamate

Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate. [GOC:obol]


negative regulation of proline degradation to glutamate

negative regulation of proline breakdown to glutamate

negative regulation of proline catabolic process to glutamate

Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate. [GOC:obol]


negative regulation of proline oxidation


positive regulation of proline degradation to glutamate

positive regulation of proline breakdown to glutamate

positive regulation of proline catabolic process to glutamate

Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate. [GOC:obol]


positive regulation of proline oxidation


regulation of cytoplasm to vacuole targeting

regulation of cytoplasm-to-vacuole targeting

regulation of protein localization by the Cvt pathway

Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway. [GOC:obol]


regulation of histone lysine H3 K79 methylation

regulation of histone H3 K79 methylation

regulation of histone H3-K79 methylation

Any process that modulates the frequency, rate or extent of histone H3-K79 methylation. [PMID:12876294]


negative regulation of histone lysine H3 K79 methylation

negative regulation of histone H3 K79 methylation

negative regulation of histone H3-K79 methylation

Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation. [PMID:12876294]


positive regulation of histone lysine H3 K79 methylation

positive regulation of histone H3 K79 methylation

positive regulation of histone H3-K79 methylation

Any process that activates or increases the frequency, rate or extent of histone H3-K79 methylation. [PMID:12876294]


regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. [PMID:15149594]


negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. [PMID:15149594]


positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. [PMID:15149594]


regulation of histone H2B ubiquitination

Any process that modulates the frequency, rate or extent of histone H2B ubiquitination. [PMID:12876293]


negative regulation of histone H2B ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B ubiquitination. [PMID:12876293]


positive regulation of histone H2B ubiquitination

Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination. [PMID:12876293]


regulation of ATP anabolism
regulation of ATP synthesis
regulation of ATP biosynthesis
regulation of ATP formation

Any process that modulates the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]


negative regulation of ATP biosynthesis
negative regulation of ATP synthesis
negative regulation of ATP anabolism
negative regulation of ATP formation

negative regulation of ATP biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]


positive regulation of ATP anabolism
positive regulation of ATP biosynthesis
positive regulation of ATP formation
positive regulation of ATP synthesis

positive regulation of ATP biosynthetic process

Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]


positive regulation of ethanol fermentation

positive regulation of glucose fermentation to ethanol

positive regulation of glycolytic fermentation to ethanol

Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol. [GOC:obol]


regulation of histone H2B conserved C-terminal lysine ubiquitination

Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. [PMID:17576814]


regulation of budding yeast H2B K123 ubiquitination


regulation of fission yeast H2B K119 ubiquitination


regulation of mammalian H2B K120 ubiquitination


negative regulation of histone H2B conserved C-terminal lysine ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. [PMID:17576814]


negative regulation of budding yeast H2B K123 ubiquitination


negative regulation of fission yeast H2B K119 ubiquitination


negative regulation of mammalian H2B K120 ubiquitination


positive regulation of histone H2B conserved C-terminal lysine ubiquitination

Any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. [PMID:17576814]


positive regulation of budding yeast H2B K123 ubiquitination


positive regulation of fission yeast H2B K119 ubiquitination


positive regulation of mammalian H2B K120 ubiquitination


Any process that modulates the frequency, rate or extent of mediator complex assembly. [GOC:obol]


negative regulation of mediator complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of mediator complex assembly. [GOC:obol]


positive regulation of mediator complex assembly

Any process that activates or increases the frequency, rate or extent of mediator complex assembly. [GOC:obol]


regulation of CD8-positive, alpha-beta T cell activation

Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]


negative regulation of CD8-positive, alpha-beta T cell activation

Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]


positive regulation of CD8-positive, alpha-beta T cell activation

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]


regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]


negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]


positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]


regulation of gamma-delta T cell activation involved in immune response

Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response. [GOC:obol]


regulation of gamma-delta T-cell activation during immune response

regulation of gamma-delta T cell activation during immune response


regulation of gamma-delta T-lymphocyte activation during immune response

regulation of gamma-delta T lymphocyte activation during immune response


negative regulation of gamma-delta T cell activation during immune response

negative regulation of gamma-delta T lymphocyte activation during immune response

negative regulation of gamma-delta T-lymphocyte activation during immune response

negative regulation of gamma-delta T-cell activation during immune response

negative regulation of gamma-delta T cell activation involved in immune response

Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response. [GOC:obol]


positive regulation of gamma-delta T cell activation involved in immune response

Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response. [GOC:obol]


positive regulation of gamma-delta T-cell activation during immune response

positive regulation of gamma-delta T cell activation during immune response


positive regulation of gamma-delta T-lymphocyte activation during immune response

positive regulation of gamma-delta T lymphocyte activation during immune response


regulation of lysine biosynthesis via aminoadipic acid and saccharopine

regulation of lysine biosynthetic process via aminoadipic acid and saccharopine

regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. [GOC:obol]


negative regulation of lysine biosynthesis via aminoadipic acid and saccharopine

negative regulation of lysine biosynthetic process via aminoadipic acid and saccharopine

negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. [GOC:obol]


positive regulation of lysine biosynthesis via aminoadipic acid and saccharopine

positive regulation of lysine biosynthetic process via aminoadipic acid and saccharopine

positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. [GOC:obol]


basement membrane assembly involved in embryonic body morphogenesis

Any basement membrane assembly that is involved in embryonic body morphogenesis. [GOC:obol]


regulation of dendritic cell differentiation

Any process that modulates the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]


negative regulation of dendritic cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]


positive regulation of dendritic cell differentiation

Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]


regulation of osteoclast cell development

Any process that modulates the frequency, rate or extent of osteoclast development. [GOC:obol]


negative regulation of osteoclast cell development

negative regulation of osteoclast development

Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. [GOC:obol]


positive regulation of osteoclast cell development

positive regulation of osteoclast development

Any process that activates or increases the frequency, rate or extent of osteoclast development. [GOC:obol]


regulation of RNA elongation from Pol I promoter

regulation of transcription elongation from RNA polymerase I promoter

Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter. [PMID:20299458]


negative regulation of transcription elongation from RNA polymerase I promoter

negative regulation of RNA elongation from Pol I promoter

negative regulation of transcription elongation by RNA polymerase I

Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I. [PMID:20299458]


positive regulation of RNA elongation from Pol I promoter

positive regulation of transcription elongation from RNA polymerase I promoter

Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter. [PMID:20299458]


regulation of acetate-mevalonate pathway

regulation of isopentenyl diphosphate anabolism, mevalonate pathway

regulation of isopentenyl diphosphate formation, mevalonate pathway

regulation of isopentenyl diphosphate synthesis, mevalonate pathway

regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway

Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. [GOC:al]


negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway

negative regulation of isopentenyl diphosphate formation, mevalonate pathway

negative regulation of acetate-mevalonate pathway

negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway

negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway

Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. [GOC:al]


Any process that modulates the frequency, rate or extent of vasculogenesis. [GOC:obol]


negative regulation of vascular morphogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. [GOC:obol]


positive regulation of vascular morphogenesis

Any process that activates or increases the frequency, rate or extent of vasculogenesis. [GOC:obol]


regulation of neuron chemotaxis
regulation of neuronal migration

Any process that modulates the frequency, rate or extent of neuron migration. [GOC:obol]


negative regulation of neuron chemotaxis

negative regulation of neuronal migration

Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. [GOC:obol]


positive regulation of neuron chemotaxis

positive regulation of neuronal migration

Any process that activates or increases the frequency, rate or extent of neuron migration. [GOC:obol]


Any process that modulates the frequency, rate or extent of chloride transport. [GOC:dph]


negative regulation of chloride transport

Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport. [GOC:dph]


regulation of response to gamma radiation

Any process that modulates the frequency, rate or extent of response to gamma radiation. [GOC:obol]


regulation of response to gamma-ray photon


negative regulation of response to gamma radiation

Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation. [GOC:obol]


negative regulation of response to gamma ray


negative regulation of response to gamma-ray photon


positive regulation of response to gamma radiation

Any process that activates or increases the frequency, rate or extent of response to gamma radiation. [GOC:obol]


positive regulation of response to gamma ray


positive regulation of response to gamma-ray photon


regulation of protein targeting to ascospore-type prospore membrane

regulation of protein-prospore membrane targeting

regulation of protein targeting to prospore membrane


regulation of protein targeting to forespore membrane


positive regulation of protein targeting to FSM

positive regulation of protein-prospore membrane targeting

positive regulation of protein targeting to ascospore-type prospore membrane

positive regulation of protein targeting to prospore membrane


positive regulation of protein targeting to forespore membrane


regulation of apoptotic signalling pathway

regulation of apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]


negative regulation of apoptotic signalling pathway

negative regulation of apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]


positive regulation of apoptotic signalling pathway

positive regulation of apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]


regulation of extrinsic apoptotic signalling pathway

regulation of extrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]


negative regulation of extrinsic apoptotic signalling pathway

negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]


negative regulation of extrinsic apoptosis


positive regulation of extrinsic apoptotic signalling pathway

positive regulation of extrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]


positive regulation of extrinsic apoptosis


regulation of extrinsic apoptotic signalling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]


regulation of dependence receptor signaling pathway


regulation of extrinsic apoptosis in absence of ligand


negative regulation of extrinsic apoptotic signalling pathway in absence of ligand

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]


negative regulation of dependence receptor signaling pathway


negative regulation of extrinsic apoptosis in absence of ligand


positive regulation of extrinsic apoptotic signalling pathway in absence of ligand

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]


positive regulation of dependence receptor signaling pathway


positive regulation of extrinsic apoptosis in absence of ligand


regulation of intrinsic apoptotic signalling pathway

regulation of mitochondrial-mediated apoptotic pathway

regulation of intrinsic apoptotic pathway

regulation of intrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]


negative regulation of intrinsic apoptotic pathway

negative regulation of mitochondrial-mediated apoptotic pathway

negative regulation of intrinsic apoptotic signalling pathway

negative regulation of intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]


negative regulation of intrinsic apoptosis


positive regulation of mitochondrial-mediated apoptotic pathway

positive regulation of intrinsic apoptotic signalling pathway

positive regulation of intrinsic apoptotic pathway

positive regulation of intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]


positive regulation of intrinsic apoptosis


regulation of phosphatidylcholine anabolism

regulation of phosphatidylcholine synthesis

regulation of phosphatidylcholine formation

regulation of phosphatidylcholine biosynthesis

regulation of phosphatidylcholine biosynthetic process

Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol]


negative regulation of phosphatidylcholine synthesis

negative regulation of phosphatidylcholine formation

negative regulation of phosphatidylcholine biosynthesis

negative regulation of phosphatidylcholine anabolism

negative regulation of phosphatidylcholine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol]


positive regulation of phosphatidylcholine synthesis

positive regulation of phosphatidylcholine anabolism

positive regulation of phosphatidylcholine biosynthesis

positive regulation of phosphatidylcholine formation

positive regulation of phosphatidylcholine biosynthetic process

Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol]


regulation of glutamate metabolic process via glutamine and ammonia

regulation of glutamate metabolism via glutamine and ammonia

regulation of ammonia assimilation cycle

Any process that modulates the frequency, rate or extent of ammonia assimilation cycle. [GOC:BHF]


negative regulation of glutamate metabolic process via glutamine and ammonia

negative regulation of glutamate metabolism via glutamine and ammonia

negative regulation of ammonia assimilation cycle

Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle. [GOC:BHF]


positive regulation of glutamate metabolism via glutamine and ammonia

positive regulation of glutamate metabolic process via glutamine and ammonia

positive regulation of ammonia assimilation cycle

Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle. [GOC:BHF]


negative regulation of chromosome organisation

negative regulation of chromosome organization

Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. [GOC:obol]


negative regulation of chromosome organization and biogenesis


negative regulation of maintenance of genome integrity


negative regulation of nuclear genome maintenance


positive regulation of chromosome organisation

positive regulation of chromosome organization

Any process that activates or increases the frequency, rate or extent of chromosome organization. [GOC:obol]


positive regulation of chromosome organization and biogenesis


positive regulation of maintenance of genome integrity


positive regulation of nuclear genome maintenance


regulation of histone H3-K36 trimethylation

Any process that modulates the frequency, rate or extent of histone H3-K36 trimethylation. [PMID:17948059]


negative regulation of histone H3-K36 trimethylation

Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K36 trimethylation. [PMID:17948059]


positive regulation of histone H3-K36 trimethylation

Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation. [PMID:17948059]


regulation of capacitative calcium entry

regulation of store-operated calcium import

regulation of store-operated calcium entry

Any process that modulates the frequency, rate or extent of store-operated calcium entry. [GOC:BHF]


regulation of nonselective cation channel activity

regulation of cation diffusion facilitator activity

Any process that modulates the frequency, rate or extent of cation channel activity. [GOC:BHF]


negative regulation of cation diffusion facilitator activity

negative regulation of nonselective cation channel activity

negative regulation of cation channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. [GOC:BHF]


positive regulation of cation diffusion facilitator activity

positive regulation of nonselective cation channel activity

positive regulation of cation channel activity

Any process that activates or increases the frequency, rate or extent of cation channel activity. [GOC:BHF]


regulation of semaphorin-plexin signalling pathway

regulation of semaphorin-plexin signaling pathway

Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway. [GOC:BHF]


negative regulation of semaphorin-plexin signalling pathway

negative regulation of semaphorin-plexin signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway. [GOC:BHF]


positive regulation of semaphorin-plexin signalling pathway

positive regulation of semaphorin-plexin signaling pathway

Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway. [GOC:BHF]


Any process that modulates the frequency, rate or extent of C-C chemokine binding. [GOC:obol]


negative regulation of C-C chemokine binding

Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding. [GOC:obol]


positive regulation of C-C chemokine binding

Any process that activates or increases the frequency, rate or extent of C-C chemokine binding. [GOC:obol]


ROBO/SLIT signaling pathway involved in axon pathfinding

ROBO signaling pathway involved in axon guidance

Roundabout signaling pathway involved in axon pathfinding

Roundabout signalling pathway involved in axon pathfinding

ROBO/SLIT signaling pathway involved in axon guidance

Roundabout signalling pathway involved in axon guidance

ROBO signaling pathway involved in axon pathfinding

Roundabout signaling pathway involved in axon guidance

Any Roundabout signaling pathway that is involved in axon guidance. [GOC:bf, PMID:14527427, PMID:21820427]


ROBO signaling pathway involved in axon chemotaxis


ROBO signaling pathway involved in axon growth cone guidance


ROBO/SLIT signaling pathway involved in axon chemotaxis


ROBO/SLIT signaling pathway involved in axon growth cone guidance


Roundabout signalling pathway involved in axon chemotaxis

Roundabout signaling pathway involved in axon chemotaxis


Roundabout signalling pathway involved in axon growth cone guidance

Roundabout signaling pathway involved in axon growth cone guidance


regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. [GOC:mtg_apoptosis]


regulation of initiator caspase activity


negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. [GOC:mtg_apoptosis]


negative regulation of initiator caspase activity


positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. [GOC:mtg_apoptosis]


positive regulation of initiator caspase activity


regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. [GOC:mtg_apoptosis]


negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. [GOC:mtg_apoptosis]


negative regulation of effector caspase activity


positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. [GOC:mtg_apoptosis]


positive regulation of effector caspase activity


regulation of leucine anabolism
regulation of leucine biosynthesis
regulation of leucine formation
regulation of leucine synthesis

regulation of leucine biosynthetic process

Any process that modulates the frequency, rate or extent of leucine biosynthetic process. [GOC:obol]


negative regulation of leucine biosynthesis

negative regulation of leucine anabolism

negative regulation of leucine synthesis

negative regulation of leucine formation

negative regulation of leucine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process. [GOC:obol]


positive regulation of leucine formation

positive regulation of leucine synthesis

positive regulation of leucine anabolism

positive regulation of leucine biosynthesis

positive regulation of leucine biosynthetic process

Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process. [GOC:obol]


regulation of unsaturated fatty acid formation

regulation of unsaturated fatty acid anabolism

regulation of unsaturated fatty acid biosynthesis

regulation of unsaturated fatty acid synthesis

regulation of unsaturated fatty acid biosynthetic process

Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process. [GO:0006636]


regulation of polyunsaturated fatty acid biosynthesis


positive regulation of unsaturated fatty acid anabolism

positive regulation of unsaturated fatty acid formation

positive regulation of unsaturated fatty acid synthesis

positive regulation of unsaturated fatty acid biosynthesis

positive regulation of unsaturated fatty acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process. [GO:0006636]


positive regulation of fatty acid desaturation


positive regulation of polyunsaturated fatty acid biosynthesis


regulation of muscle cell chemotaxis towards tendon cell

regulation of muscle cell chemotaxis toward tendon cell

Any process that modulates the frequency, rate or extent of muscle cell chemotaxis toward tendon cell. [GOC:sart]


negative regulation of muscle cell chemotaxis towards tendon cell

negative regulation of muscle cell chemotaxis toward tendon cell

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells. [GOC:sart, PMID:19793885, PMID:20404543]


negative regulation of muscle cell attraction


ROBO/SLIT signaling pathway involved in muscle cell chemotaxis toward tendon cell

Roundabout signalling pathway involved in muscle cell chemotaxis toward tendon cell

ROBO signaling pathway involved in muscle cell chemotaxis towards tendon cell

ROBO signaling pathway involved in muscle cell chemotaxis toward tendon cell

ROBO/SLIT signaling pathway involved in muscle cell chemotaxis towards tendon cell

Roundabout signaling pathway involved in muscle cell chemotaxis towards tendon cell

Roundabout signalling pathway involved in muscle cell chemotaxis towards tendon cell

Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell

Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. [GOC:bf, GOC:obol, GOC:sart, PMID:19793885]


ROBO signaling pathway involved in muscle cell attraction


ROBO/SLIT signaling pathway involved in muscle cell attraction


Roundabout signalling pathway involved in muscle cell attraction

Roundabout signaling pathway involved in muscle cell attraction


regulation of bone morphogenetic protein secretion

Any process that modulates the frequency, rate or extent of BMP secretion. [GOC:sart]


negative regulation of BMP protein secretion

negative regulation of bone morphogenetic protein secretion

Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion. [GOC:sart]


regulation of caveolae-mediated endocytosis

regulation of caveolae-dependent endocytosis

regulation of caveolin-dependent endocytosis

regulation of caveolin-mediated endocytosis

Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis. [GOC:obol]


negative regulation of caveolae-dependent endocytosis

negative regulation of caveolin-dependent endocytosis

negative regulation of caveolae-mediated endocytosis

negative regulation of caveolin-mediated endocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis. [GOC:obol]


positive regulation of caveolin-dependent endocytosis

positive regulation of caveolae-mediated endocytosis

positive regulation of caveolae-dependent endocytosis

positive regulation of caveolin-mediated endocytosis

Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis. [GOC:obol]


The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate. [GOC:obol]


2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolic process


2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolic process


The chemical reactions and pathways involving a hydroperoxide. [GOC:rs, PMID:15917183, PMID:18084891]


The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties. [GOC:yaf]


codeine breakdown
codeine catabolism
codeine degradation

The chemical reactions and pathways resulting in the breakdown of codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties. [GOC:yaf, UniPathway:UPA00318]


The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf, PMID:11902724, PMID:15726818, PMID:18981598]


malonyl-CoA degradation
malonyl-CoA breakdown
malonyl-CoA catabolism

The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf]


malonyl-CoA biosynthesis
malonyl-CoA formation
malonyl-CoA synthesis
malonyl-CoA anabolism

The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf, UniPathway:UPA00655]


The chemical reactions and pathways involving N(omega)-methyl-L-arginine. [GOC:rs, PMID:10510241]


N(omega)-methyl-L-arginine breakdown
N(omega)-methyl-L-arginine catabolism
N(omega)-methyl-L-arginine degradation

The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine. [GOC:rs, PMID:10510241]


The chemical reactions and pathways involving N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group. [GOC:rs, PMID:10510241]


The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group. [GOC:rs, PMID:10510241]


The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid. [GOC:mw]


lipoxin formation
lipoxin synthesis
lipoxin anabolism
lipoxin biosynthesis

The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid. [GOC:mw]


lipoxin A4 metabolism
LXA4 metabolic process
LXA4 metabolism

The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. [GOC:mw]


lipoxin A4 synthesis
LXA4 synthesis
lipoxin A4 anabolism
LXA4 biosynthetic process
lipoxin A4 formation
LXA4 anabolism
LXA4 formation
LXA4 biosynthesis
lipoxin A4 biosynthesis

The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. [GOC:mw]


LXB4 metabolic process
lipoxin B4 metabolism
LXB4 metabolism

The chemical reactions and pathways involving lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. [GOC:mw]


xanthones metabolic process
xanthones metabolism
xanthone metabolism
xanthone-containing compound metabolism

xanthone-containing compound metabolic process

The chemical reactions and pathways involving a xanthone-containing compound. [GOC:di]


lipoxin B4 formation
LXB4 formation
lipoxin B4 anabolism
LXB4 synthesis
lipoxin B4 biosynthesis
LXB4 anabolism
lipoxin B4 synthesis
LXB4 biosynthesis
LXB4 biosynthetic process

The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. [GOC:mw]


xanthone-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of a xanthone-containing compound. [GOC:di]


The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. [PMID:16333108, PMID:17574915, PMID:18272357]


gliotoxin degradation
gliotoxin breakdown
gliotoxin catabolism

The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357]


gliotoxin anabolism
gliotoxin synthesis
gliotoxin formation
gliotoxin biosynthesis

The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357, PMID:29966253]


bis(monoacylglycerol) hydrogen phosphate (BMP) metabolic process

bis(monoacylglycerol) hydrogen phosphate (BMP) metabolism

bis(monoacylglycerol) hydrogen phosphate metabolic process

bis(monoacylglycerol) hydrogen phosphate metabolism

lysobisphosphatidic acid metabolic process

The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group. [GOC:mw]


bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthetic process

bis(monoacylglycerol) hydrogen phosphate (BMP) anabolism

bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthesis

bis(monoacylglycerol) hydrogen phosphate biosynthesis

bis(monoacylglycerol) hydrogen phosphate formation

bis(monoacylglycerol) hydrogen phosphate anabolism

bis(monoacylglycerol) hydrogen phosphate biosynthetic process

bis(monoacylglycerol) hydrogen phosphate (BMP) synthesis

bis(monoacylglycerol) hydrogen phosphate synthesis

bis(monoacylglycerol) hydrogen phosphate (BMP) formation

lysobisphosphatidic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group. [GOC:mw]


The chemical reactions and pathways involving a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. [GOC:yaf]


The chemical reactions and pathways resulting in the breakdown of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. [GOC:yaf]


The chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. [GOC:yaf, UniPathway:UPA00032]


UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity


uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity


uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity


The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]


nucleobase-containing compound transmembrane transporter activity

Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. [GOC:ai]


nucleobase-containing small molecule interconversion

The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. [GOC:mah, ISBN:0306444747, ISBN:0471394831]


nuclear-encoded tRNA import into mitochondrion


long-chain fatty-acyl-CoA hydrolase activity


mitochondrial fatty acid beta-oxidation multienzyme complex location

A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. [GOC:ma]


A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins. [PMID:10464333, PMID:8910335]


nucleobase-containing compound kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. [GOC:jl]


regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process


L-threonine catabolic process to methylglyoxal

L-threonine catabolic process to D-lactate

The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate. [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY]


L-threonine catabolic process to (R)-lactate


L-threonine catabolic process to pyruvate


L-threonine degradation to glycine
L-threonine catabolism to glycine
L-threonine breakdown to glycine

L-threonine catabolic process to glycine

The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine. [GOC:bf, GOC:mah, MetaCyc:THREONINE-DEG2-PWY]


catechol-containing compound catabolic process

The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. [GOC:go_curators]


forebrain anterior-posterior pattern specification

forebrain anterior/posterior pattern specification

The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]


ionotropic neurotransmitter receptor activity


A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732]


intracellular steroid hormone receptor signaling pathway

The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. [GOC:mah, GOC:signaling]


intracellular estrogen receptor signaling pathway

The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]


IFT complex A
IFT complex A location
IFT A complex location


Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. [GOC:mah]


RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding


DNA-dependent transcriptional start site selection

DNA-templated transcriptional start site selection

Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH, PMID:16826228, PMID:18846104]


transcriptional start site selection at RNA polymerase II promoter

Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH, PMID:16826228, PMID:18846104]


transcriptional start site selection at RNA polymerase III promoter

Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH]


regulation of transcriptional open complex formation at RNA polymerase II promoter

regulation of transcription open complex formation at RNA polymerase II promoter

Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. [GOC:txnOH]


regulation of transcription start site selection at RNA polymerase II promoter

regulation of transcriptional start site selection at RNA polymerase II promoter

Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH]


RNA polymerase I transcription factor binding


core RNA polymerase I binding transcription factor activity

transcription factor activity, core RNA polymerase I binding


promoter clearance from RNA polymerase I promoter

Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. [GOC:txnOH]


transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I. [GOC:txnOH]


promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript

Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. [GOC:txnOH]


RNA polymerase I transcriptional preinitiation complex assembly

RNA polymerase I preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter. [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]


maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter

maintenance of transcriptional fidelity during DNA-templated transcription elongation

Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template. [GOC:txnOH]


maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter

maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter

Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter. [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246]


maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter

maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter

Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter. [GOC:txnOH]


RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding

metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity


RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding

RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding

metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity


RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding

RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding

copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity


RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding

RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding

zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity


transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding

sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription


transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding

sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription


muscarinic acetylcholine receptor binding

G-protein coupled acetylcholine receptor binding

G protein-coupled acetylcholine receptor binding

Binding to a G protein-coupled acetylcholine receptor. [GOC:bf, GOC:mah, GOC:nln]


M1 muscarinic acetylcholine receptor ligand


M2 muscarinic acetylcholine receptor ligand


M3 muscarinic acetylcholine receptor ligand


M4 muscarinic acetylcholine receptor ligand


M5 muscarinic acetylcholine receptor ligand


signal transduction involved in positive regulation of conjugation with cellular fusion

The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. [GOC:mah]


meiotic attachment of telomeric heterochromatin to spindle pole body

The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation. [GOC:pr, PMID:16615890]


attachment of telomeric chromatin to spindle pole body


regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport

regulation of nucleobase-containing compound transport

Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]


negative transcription elongation regulator activity


positive transcription elongation regulator activity


negative regulation of mast cell apoptosis

negative regulation of mast cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]


positive regulation of mast cell apoptosis

positive regulation of mast cell apoptotic process

Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]


negative regulation of neutrophil apoptosis

negative regulation of neutrophil apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process. [GOC:add, GOC:mtg_apoptosis]


positive regulation of neutrophil apoptosis

positive regulation of neutrophil apoptotic process

Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process. [GOC:add, GOC:mtg_apoptosis]


negative regulation of myeloid cell apoptosis


regulation of intracellular steroid hormone receptor signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]


negative regulation of intracellular steroid hormone receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]


positive regulation of intracellular steroid hormone receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]


positive regulation of intracellular estrogen receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. [GOC:mah]


Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]


tumor necrosis factor alpha-mediated signaling pathway


serotonin receptor activity, coupled via Gq/11

Gq/11-coupled serotonin receptor activity

Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]


adenylate cyclase inhibiting metabotropic glutamate receptor activity


negative regulation by symbiont of host apoptosis


Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. [EC:3.1.3.75]


dihydroxy fatty acid phosphatase activity


positive regulation of glial cell apoptosis

positive regulation of glial cell apoptotic process

Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. [GOC:mah, GOC:mtg_apoptosis]


nucleobase, nucleoside, nucleotide and nucleic acid synthesis


nucleobase, nucleoside, nucleotide and nucleic acid catabolic process


histone deacetylase activity (H4-K16 specific)

Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. [GOC:vw, PMID:28450737]


Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O. [UM-BBD_reactionID:r1059]


CCA tRNA nucleotidyltransferase activity


transfer ribonucleate adenylyltransferase activity


transfer ribonucleate cytidylyltransferase activity


transfer ribonucleate nucleotidyltransferase activity


transfer ribonucleic acid nucleotidyl transferase activity


transfer ribonucleic adenylyl (cytidylyl) transferase activity


transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity


transfer RNA adenylyltransferase activity


embryonic heart tube anterior/posterior pattern specification

The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta. [GOC:bf, PMID:12435360]


negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP

negative regulation of BMP signaling pathway by extracellular sequestering of BMP

negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein

sequestering of BMP in extracellular matrix

Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. [GOC:BHF, PMID:20855508]


sequestering of TGFbeta large latency complex in extracellular matrix

sequestering of TGFbeta LLC in extracellular matrix

negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta

negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta

sequestering of TGFbeta in extracellular matrix

Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins. [GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508]


envenomation resulting in modification of morphology or physiology of other organism

envenomation resulting in modulation of process in other organism

envenomation resulting in modulation of process in another organism

The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism. [GOC:pamgo_curators]


A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]


The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons. [CL:0000561, GOC:bf]


defecation motor program
DMP
defecation cycle

The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated. [GOC:bf, GOC:kmv, PMID:7479775, PMID:8158250, PMID:9066270]


The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. [CL:0000164, GOC:bf]


The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues. [GOC:rs, ISBN:0198506732]


Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain. [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509]


vascular smooth muscle cell differentiation

vascular associated smooth muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. [GOC:sl, PMID:16151017, PMID:18267954]


aortic smooth muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. [GOC:sl]


2-hydroxyadenine deaminase activity
2-oxoadenine deaminase activity

Catalysis of the reaction: isoguanine + H2O = xanthine + NH3. [EC:3.5.4.-, GOC:imk, PMID:21604715]


The attachment of a developing otolith to the kinocilia of tether cells in the inner ear. [GOC:dgh, PMID:14499652]


The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, GOC:rs, PMID:19325115]


modulation of platelet aggregation in other organism

modulation by organism of platelet aggregation in other organism

modulation of platelet aggregation in another organism

Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:bf, GOC:fj, PMID:15922770]


regulation of platelet aggregation in other organism


down-regulation of platelet aggregation in other organism

negative regulation of platelet aggregation in other organism

suppression of platelet aggregation in other organism

downregulation of platelet aggregation in other organism

inhibition of platelet aggregation in other organism

negative regulation of platelet aggregation in another organism

Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism. [GOC:bf, GOC:fj, PMID:15922770]


positive regulation of platelet aggregation in other organism

upregulation of platelet aggregation in other organism

positive regulation of platelet aggregation in another organism

Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism. [GOC:bf, GOC:fj, PMID:11453648, PMID:18804547]


up-regulation of platelet aggregation in other organism


modulation of mast cell degranulation in other organism

regulation of mast cell degranulation in other organism

modulation of mast cell degranulation in another organism

Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. [GOC:bf, GOC:fj, PMID:21549739]


upregulation of mast cell degranulation in other organism

positive regulation of mast cell degranulation in other organism

positive regulation of mast cell degranulation in another organism

Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism. [GOC:bf, GOC:fj]


up-regulation of mast cell degranulation in other organism


parathyrin secretion
parathormone secretion
PTH secretion

The regulated release of parathyroid hormone into the circulatory system. [GOC:cjm, PMID:12171519, PMID:21164021]


down-regulation of blood coagulation in other organism

negative regulation of blood clotting in other organism

negative regulation of blood coagulation in other organism

suppression of blood coagulation in other organism

downregulation of blood coagulation in other organism

negative regulation of blood coagulation in another organism

Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. [GOC:fj]


inhibition of blood coagulation in other organism


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. [GOC:bf, PMID:20203532]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. [GOC:bf, PMID:20203532]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. [GOC:bf, PMID:17683801, PMID:19893991]


cellular response to immobilisation stress

cellular response to immobilization stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. [GOC:bf, PMID:17683801, PMID:19893991]


The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]


The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]


The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]


The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]


The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]


The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]


The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]


The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]


The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]


The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]


The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. [CL:0000188, GOC:BHF, GOC:vk]


pore complex biogenesis in other organism

pore formation in membrane of other organism

pore formation in membrane of another organism

The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism. [GOC:bf, GOC:fj, PMID:21549739]


modulation of calcium channel activity in other organism

modulation of calcium channel activity in another organism

Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism. [GOC:bf, GOC:fj, PMID:20920515]


downregulation of calcium channel activity in other organism

down-regulation of calcium channel activity in other organism

negative regulation of calcium channel activity in other organism

negative regulation of calcium channel activity in another organism

Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism. [GOC:bf, GOC:fj, PMID:20920515]


inhibition of calcium channel activity in other organism


down-regulation of voltage-gated calcium channel activity in other organism

negative regulation of voltage-dependent calcium channel activity in other organism

negative regulation of voltage-sensitive calcium channel activity in other organism

negative regulation of voltage-gated calcium channel activity in other organism

negative regulation of voltage gated calcium channel activity in other organism

downregulation of voltage-gated calcium channel activity in other organism

negative regulation of voltage-gated calcium channel activity in another organism

Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]


inhibition of voltage-gated calcium channel activity in other organism


negative regulation of low voltage-dependent calcium channel activity in other organism

negative regulation of low voltage-gated calcium channel activity in other organism

negative regulation of low voltage gated calcium channel activity in other organism

down-regulation of low voltage-gated calcium channel activity in other organism

downregulation of low voltage-gated calcium channel activity in other organism

negative regulation of low voltage-gated calcium channel activity in another organism

Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]


inhibition of low voltage-gated calcium channel activity in other organism


downregulation of high voltage-gated calcium channel activity in other organism

negative regulation of high voltage-dependent calcium channel activity in other organism

negative regulation of high voltage-gated calcium channel activity in other organism

down-regulation of high voltage-gated calcium channel activity in other organism

negative regulation of high voltage gated calcium channel activity in other organism

negative regulation of high voltage-gated calcium channel activity in another organism

Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]


inhibition of high voltage-gated calcium channel activity in other organism


The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671]


Binding to flurbiprofen. [GOC:BHF, GOC:rl]


cellular response to vascular endothelial growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, PMID:18440775]


mRNA 3'-UTR adenylate/uridylate-rich element binding

Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]


The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix. [GOC:ans, PMID:20691904]


cytoplasmic RNA import into mitochondrion


nuclear-encoded RNA import into mitochondrion


The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix. [GOC:ans, PMID:20691904]


cytoplasmic rRNA import into mitochondrion


nuclear-encoded rRNA import into mitochondrion


The regulated release of any steroid that acts as a hormone into the circulatory system. [GOC:sl]


The regulated release of any corticosteroid hormone into the circulatory system. [GOC:sl]


The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism. [GOC:sl]


The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. [GOC:sl]


The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood. [GOC:sl]


The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. [GOC:sl]


The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. [GOC:sl]


The regulated release of estradiol into the circulatory system. [GOC:sl, PMID:21632818]


VNTR binding
microsatellite DNA binding
variable number tandem repeat binding

Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem. [GOC:yaf, PMID:21290414, SO:0000289]


The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system. [GOC:sl]


The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system. [GOC:sl]


The regulated release of estrone into the circulatory system. [GOC:sl, PMID:8395854]


The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]


mitochondrial aberrant ncRNA catabolic process

mitochondrial non-coding RNA surveillance

The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion. [GOC:ans, PMID:19864255]


mitochondrial messenger RNA surveillance

mitochondrial aberrant RNA catabolic process

The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion. [GOC:ans, PMID:19864255]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. [GOC:sjw, PMID:20100461]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. [GOC:sjw, PMID:20100461]


The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle. [GOC:br, PMID:10052452, PMID:17041781]


Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids. [GOC:bf, GOC:rb, PMID:19244244]


response to topologically incorrect protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. [GOC:bf]


response to misfolded or unfolded protein


cellular response to topologically incorrect protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. [GOC:bf]


cellular response to misfolded or unfolded protein


The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. [GOC:bf]


The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine. [GOC:BHF, GOC:vk, PMID:12383260]


Selective degradation of protein aggregates by macroautophagy. [GOC:autophagy, GOC:kmv, PMID:18508269, PMID:25062811]


The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome. [GOC:vw, PMID:21775631]


carbamoyl phosphate degradation
carbamoyl phosphate catabolism
carbamoyl phosphate breakdown

The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. [GOC:yaf, UniPathway:UPA00996]


protein deglycosylation involved in glycoprotein catabolic process

The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein. [GOC:bf, GOC:vw]


The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone. [GOC:yaf, PMID:16061642]


histone kinase activity (H2A-S139 specific)

Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A. [GOC:yaf, PMID:16061642]


histone kinase activity (H2A.x-S139 specific)


The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell. [CL:0002673, GOC:yaf, PMID:3393851]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus. [GOC:yaf, PMID:20181743]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus. [GOC:yaf, PMID:20181743]


A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes. [GOC:yaf, PMID:15621527, PMID:21248468]


The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. [CL:0000223, GOC:yaf, PMID:17624332]


cartilage cell proliferation
chondrocyte cell proliferation

The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [CL:0000138, GOC:yaf, PMID:21484705]


The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. [GOC:yaf, PMID:21412429, UBERON:0000043]


tenocyte differentiation
muscle attachment cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance. [CL:0000388, GOC:yaf, PMID:21412429]


Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO). [GOC:kmv, PMID:21491957]


The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. [GOC:yaf, PMID:17567668, UBERON:0000043]


The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase. [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. [GOC:BHF, GOC:vk, PMID:14583192]


The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal. [PMID:14583192]


Thin cylindrical membrane-covered projection on the surface of a rhabdomere. [GOC:bf, GOC:sart, PMID:14744998]


The portion of the plasma membrane surrounding a microvillus of a rhabdomere. [GOC:bf, GOC:sart, PMID:14744998]


7,8-dihydroneopterin 3'-triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate. [GOC:yaf, UniPathway:UPA00848]


The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. [GOC:yaf, PMID:1825999, UniPathway:UPA00193]


A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion. [GOC:mag, PMID:10723937, PMID:4629881]


'de novo' pyridoxal 5'-phosphate formation

'de novo' pyridoxal 5'-phosphate synthesis

'de novo' pyridoxal 5'-phosphate biosynthesis

'de novo' pyridoxal 5'-phosphate anabolism

'de novo' pyridoxal 5'-phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components. [GOC:bf, GOC:yaf, MetaCyc:PYRIDOXSYN-PWY]


'de novo' pyridoxal phosphate biosynthetic process


Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]


protein-coding primary transcript binding


positive regulation of transcription from RNA polymerase II promoter in response to stress

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mcc]