Binding to activin, a dimer of inhibin-beta subunits. [GOC:jid, GOC:mah]


Binding to a protein or protein complex using energy from ATP hydrolysis. [GOC:jl]


Binding to beta-2-microglobulin. [GOC:mah]


Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. [ISBN:0198506732]


Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. [GOC:jl, http://lookwayup.com/]


Binding to the microtubule constituent protein alpha-tubulin. [GOC:jl]


Binding to the microtubule constituent protein gamma-tubulin. [GOC:jl]


Binding to an histone acetyltransferase. [GOC:bf]


Binding to histone deacetylase. [GOC:jl]


mitogen-activated protein kinase p38 binding

Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. [GOC:curators, PMID:17827184]


neurotrophin binding
NT-4/5 binding
neurotrophin-4/5 binding
neurotrophic factor binding
neurotrophin 4/5 binding
neurotrophin

Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. [GOC:jl]


Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. [GOC:go_curators, GOC:krc]


Binding to a histone in which a residue has been modified by methylation. [GOC:bf, PMID:14585615]


Binding to an immunoglobulin of the IgM isotype. [GOC:add, ISBN:0781735149]


Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


polymeric immunoglobulin receptor activity

Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes. [GOC:add, ISBN:0781735149]


The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]


The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. [ISBN:0198506732]


Binding to a nonidentical protein to form a heterodimer. [GOC:ai]


Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. [PMID:9682036]


Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. [PMID:9682036]


Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. [PMID:12054670]


Binding to a protein's DNA binding domain (DBD). [PMID:9682036]


Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036]


Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. [GOC:jl, Pfam:PF00169]


Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. [PMID:11684676, PMID:12215544]


Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. [PMID:14531730]


N-terminal end binding
N-terminal binding

Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. [ISBN:0198506732]


OBSOLETE. Interacting selectively with identical proteins to form a homooligomer. [GOC:jl]


Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. [PMID:11133832]


Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein. [PMID:11133832]


Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein. [PMID:11133832]


Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules. [PMID:12594855]


Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]


Binding to X11-like protein, a neuron-specific adaptor protein. [GOC:jl, PMID:12780348]


Binding to a nuclear androgen receptor. [GOC:ai]


OBSOLETE. Interacting selectively with an apolipoprotein E receptor. [GOC:ai]


Binding to CD154, a receptor found on the surface of some activated lymphocytes. [GOC:jl, ISBN:0120781859]


Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages. [GOC:jl, MSH:D015704]


Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells. [GOC:jl, ISBN:0120781859]


Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. [GOC:jl, MSH:D016827]


Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells. [GOC:jl, ISBN:0120781859]


Binding to CD40, a receptor found on the surface of all B-lymphocytes. [GOC:jl, ISBN:0120781859]


Binding to a neurotrophin TRKA receptor. [GOC:ai]


platelet-derived growth factor
PDGFR binding
PDGF receptor binding
PDGF

Binding to a platelet-derived growth factor receptor. [GOC:ai]

platelet-derived growth factor receptor binding


Binding to a tumor necrosis factor receptor. [GOC:ai]


vascular endothelial growth factor receptor binding

Binding to a vascular endothelial growth factor receptor. [GOC:ai]


Binding to a dopamine receptor. [GOC:ai]


ephrin receptor binding
Eph receptor binding


epidermal growth factor receptor binding

transforming growth factor alpha receptor binding

Binding to an epidermal growth factor receptor. [GOC:ai]


Binding to a CXCR3 chemokine receptor. [GOC:jid, PMID:10556837]


glial cell line-derived neurotrophic factor receptor ligand


low-density lipoprotein receptor binding

low-density lipoprotein particle receptor binding

Binding to a low-density lipoprotein receptor. [GOC:ai]


major histocompatibility complex class I binding

Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]


major histocompatibility complex class II binding

Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]


major histocompatibility complex class II protein binding, via antigen binding groove

MHC class II protein binding, via antigen binding groove

Binding to the antigen binding groove of major histocompatibility complex class II molecules. [GOC:jl]


major histocompatibility complex class II protein binding, via lateral surface

MHC class II protein binding, via lateral surface

Binding to the lateral surface of major histocompatibility complex class II molecules. [GOC:jl]


Binding to one or more specific sites on a neuromedin U receptor. [GOC:jl, PMID:10899166]


peroxisome proliferator activated receptor binding

Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma. [GOC:jl, PMID:12769781]


The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted. [GOC:clt, GOC:elh]


advanced glycation end-product receptor binding

Binding to a RAGE receptor, the receptor for advanced glycation end-products. [GOC:ai]


Interacts with chemokine receptors to reduce the action of a chemokine. [GOC:ai, ISBN:0781718325]


retinoic acid receptor binding
RAR binding

Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. [GOC:jl, PMID:12476796]


Binding to a nuclear retinoid X receptor. [GOC:ai]


TCR binding
T lymphocyte receptor binding
T-cell receptor binding
T-lymphocyte receptor binding

Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. [GOC:jl]


Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom. [GOC:pt]


transforming growth factor beta receptor binding

Binding to a transforming growth factor beta receptor. [GOC:ai]


vitamin D receptor binding
VDR binding
calciferol receptor binding

Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. [GOC:jl, PMID:12637589]


RNP binding
protein-RNA complex binding
ribonucleoprotein binding

Binding to a complex of RNA and protein. [GOC:bf, GOC:go_curators, GOC:vk]


Binding to a large ribosomal subunit. [GOC:go_curators]


Binding to a small ribosomal subunit. [GOC:go_curators]


Binding to a ribosome. [GOC:go_curators]


Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. [GOC:curators, ISBN:0198506732]


Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. [GOC:curators]


OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate. [PMID:12084835]


Catalysis of a ring closure reaction. [ISBN:0198547684]


Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol). [PMID:12213958]


Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate. [MetaCyc:PROLINE-MULTI]


D-lactate dehydratase
(R)-lactate hydro-lyase

Catalysis of the reaction: methylglyoxal + H2O = D-lactate. [GOC:mcc, PMID:21696459, PMID:7848303, RHEA:27754]


hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement

OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance. [EC:3.6.5.-, GOC:ai]


ATP-dependent transmembrane transporter activity

ATPase activity, coupled to transmembrane movement of substances

ATP-coupled transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729]


ATP-dependent antimonite transporter activity

ATPase-coupled antimonite transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out). [EC:7.3.2.7]


L-arabinose porter activity
L-arabinose-importing ATPase activity

ABC-type L-arabinose transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in). [RHEA:30007]


phosphonate transporting ATPase activity

organic phosphonate transmembrane-transporting ATPase activity

ATPase-coupled organic phosphonate transmembrane transporter activity


ATPase activity, coupled to transmembrane movement of ions

ATPase coupled ion transmembrane transporter activity

ATP-dependent ion transmembrane transporter activity

ATPase-coupled ion transmembrane transporter activity

Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


proton-exporting ATPase activity, phosphorylative mechanism

hydrogen exporting ATPase activity, phosphorylative mechanism

hydrogen-exporting ATPase activity, phosphorylative mechanism

P-type proton-exporting transporter activity

Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle. [RHEA:20852]


Na(+)-transporting ATPase activity
Na+-exporting ATPase activity
Na(+)-exporting ATPase activity
Na+-transporting ATPase activity


hydrogen ion transporting ATPase activity, rotational mechanism

proton-transporting ATPase activity, rotational mechanism

hydrogen ion transporting two-sector ATPase activity

hydrogen ion translocating F-type ATPase activity

Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. [RHEA:57721]

ATP phosphohydrolase (H+-transporting) activity


ATP synthase, sodium ion specific activity

Na(+)-transporting two-sector ATPase activity

ATP phosphohydrolase (Na+-transporting) activity

sodium transporting ATPase activity, rotational mechanism

sodium-transporting ATPase activity, rotational mechanism

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism. [PMID:30791207, RHEA:58157]


Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate. [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN]


Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate. [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN]


adenosine diphosphoribose pyrophosphatase activity

Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]


adenosine triphosphate pyrophosphatase activity

Catalysis of the reaction: ATP + H2O = AMP + diphosphate. [RHEA:14245]


Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+). [GOC:mah]


diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity

diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity

Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+). [EC:3.6.1.29, RHEA:13893]


cytidine diphosphoglycerol pyrophosphatase activity

Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+). [EC:3.6.1.16, RHEA:21692]


dCTP nucleotidohydrolase activity
deoxycytidine-triphosphatase activity
deoxy-CTPase activity
deoxycytidine triphosphatase activity
dCTPase activity
dCTP pyrophosphatase activity

Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate. [RHEA:22636]


dolichyl diphosphate phosphohydrolase activity

Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN]


riboflavine adenine dinucleotide pyrophosphatase activity

riboflavin adenine dinucleotide pyrophosphatase activity

Catalysis of the reaction: FAD + H2O = AMP + FMN. [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN]


Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN]


Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. [MetaCyc:3.6.1.19-RXN]


Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate. [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN]


diacylglycerol diphosphate phosphatase activity

Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate. [GOC:kad, PMID:8567632, PMID:9452443]

diacylglycerol pyrophosphate phosphatase activity


Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate. [EC:3.6.1.28, RHEA:11744]


thymidine triphosphate nucleotidohydrolase activity

Catalysis of the reaction: dTTP + H2O = dTDP + phosphate. [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN]


inorganic trimetaphosphatase activity
trimetaphosphate hydrolase activity

Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate. [EC:3.6.1.2, RHEA:11088]


inorganic triphosphatase activity
tripolyphosphatase activity
triphosphate phosphohydrolase activity

Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate. [EC:3.6.1.25, RHEA:14157]


Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. [PMID:18411271, RHEA:28094]


adenosine 5-phosphosulfate sulfohydrolase activity

Catalysis of the reaction: 5'-adenylyl sulfate + H(2)O = AMP + 2 H(+) + sulfate. [EC:3.6.2.1, RHEA:17041]


3-phosphoadenosine 5-phosphosulfate sulfatase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate. [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN]


Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate. [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN]


oxidized PVA hydrolase activity
b-diketone hydrolase activity
nonane-4,6-dione acylhydrolase activity

Catalysis of the reaction: H(2)O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one. [EC:3.7.1.7, RHEA:11908]


Catalysis of the reaction: cyclohexane-1,3-dione + H(2)O = 5-oxohexanoate + H(+). [EC:3.7.1.10, RHEA:16473]


Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol. [EC:3.7.1.4, RHEA:23396]


Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate. [EC:3.11.1.1, RHEA:18905]


Catalysis of the reaction: H(2)O + phosphonoacetate = acetate + H(+) + phosphate. [EC:3.11.1.2, RHEA:16749]


Catalysis of the reaction: 4-chlorobenzoate + H(2)O = 4-hydroxybenzoate + chloride + H(+). [EC:3.8.1.6, RHEA:23440]


haloalkane halidohydrolase activity
alkyl-halide halidohydrolase activity

Catalysis of the reaction: bromochloromethane + H(2)O = bromide + chloride + formaldehyde + 2 H(+). [RHEA:13765]


phosphamide hydrolase activity
creatine phosphatase activity

Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate. [EC:3.9.1.1, RHEA:12977]


Catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate. [EC:3.12.1.1, RHEA:21884]


Catalysis of the reaction: 2,5-dioxopiperazine + H(2)O = glycylglycine. [EC:3.5.2.13, RHEA:21808]


Catalysis of the reaction: barbiturate + H2O = malonate + urea. [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN]


Catalysis of the reaction: L-5-carboxymethylhydantoin + H(2)O = N-carbamoyl-L-aspartate + H(+). [EC:3.5.2.4, RHEA:12028]


creatinine hydrolase
creatinine amidohydrolase activity

Catalysis of the reaction: creatinine + H(2)O = creatine. [EC:3.5.2.10, RHEA:14533]


4(5)-imidazolone-5(4)-propionic acid hydrolase activity

imidazolone propionic acid hydrolase activity

Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+). [EC:3.5.2.7, RHEA:23660]


Catalysis of the reaction: L-2-aminohexano-6-lactam + H(2)O = L-lysine. [EC:3.5.2.11, RHEA:21388]


Catalysis of the reaction: H(2)O + maleimide = H(+) + maleamate. [EC:3.5.2.16, RHEA:24476]


Catalysis of the reaction: N-methylhydantoin + ATP + 2 H(2)O = N-carbamoylsarcosine + ADP + 3 H(+) + phosphate. [EC:3.5.2.14, RHEA:11720]


Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H(2)O + H(+) = 2,5-dioxopentanoate + NH(4)(+). [EC:3.5.4.22, RHEA:10560]


adenosine (phosphate) deaminase activity

Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP. [EC:3.5.4.17, GOC:bf, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN]


adenosine diphosphate deaminase activity

Catalysis of the reaction: ADP + H2O = IDP + NH3. [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN]


Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3). [RHEA:22348]


adenosine triphosphate deaminase activity

Catalysis of the reaction: ATP + H2O = ITP + NH3. [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN]


Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3. [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN]


creatinine desiminase activity
creatinine iminohydrolase activity

Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3. [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3. [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN]


guanosine aminase activity
guanosine aminohydrolase activity

Catalysis of the reaction: guanosine + H2O = xanthosine + NH3. [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]


Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3. [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN]


Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3. [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN]


Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+). [EC:3.5.4.28, RHEA:20716]


Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3. [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN]


Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine. [EC:3.5.1.85, RHEA:23952]


alpha-(N-acetylaminomethylene)succinic acid hydrolase activity

2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)

Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate. [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN]


alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity

2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)

Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H(2)O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO(2) + NH(4)(+). [EC:3.5.1.66, RHEA:17677]


Catalysis of the reaction: 4-methylene-L-glutamine + H(2)O = 4-methylene-L-glutamate + NH(4)(+). [EC:3.5.1.67, RHEA:14741]


Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3. [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN]


Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate. [EC:3.5.1.17]


acylagmatine amidohydrolase activity
acylagmatine deacylase activity
benzoylagmatine amidohydrolase activity

Catalysis of the reaction: N(4)-benzoylagmatine + H(2)O = agmatine + benzoate. [EC:3.5.1.40, RHEA:15065]


Catalysis of the reaction: N-methylhexanamide + H(2)O = hexanoate + methylammonium. [EC:3.5.1.39, RHEA:20081]


pseudocholinesterase (associated with arylacylamidase)

brain acetylcholinesterase (is associated with AAA-2)

Catalysis of the reaction: anilide + H(2)O = a carboxylate + aniline + H(+). [EC:3.5.1.13, RHEA:20297]


Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine. [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN]


biotin-amide amidohydrolase activity
amidohydrolase biotinidase activity

Catalysis of the reaction: biotin amide + H2O = biotin + NH3. [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN]


carnitine amidase activity
L-carnitine amidase activity
L-carnitinamidase activity
L-carnitinamide amidohydrolase activity

Catalysis of the reaction: (R)-carnitinamide + H(2)O = (R)-carnitine + NH(4)(+). [EC:3.5.1.73, RHEA:17537]


Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine. [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN]


Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine. [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN]


Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H(2)O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H(+). [EC:3.5.1.72, RHEA:14421]


Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate. [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN]


Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate. [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN]


Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate. [EC:3.5.1.51, RHEA:22928]


Catalysis of the reaction: N-acetylputrescine + H(2)O = acetate + putrescine. [EC:3.5.1.62, RHEA:23412]


Catalysis of the reaction: N(8)-acetylspermidine + H(2)O = acetate + spermidine. [EC:3.5.1.48, RHEA:23928]


NAD-dependent histone deacetylase activity (H3-K9 specific)

Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. [PMID:28450737]


NAD-dependent histone deacetylase activity (H4-K16 specific)

Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. [GOC:vw, PMID:28450737]


Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate. [EC:3.5.1.21, RHEA:23212]


N-acetyl-L-diaminopimelic acid deacylase activity

Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate. [EC:3.5.1.47, RHEA:20405]


Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate. [EC:3.5.1.25, MetaCyc:3.5.1.80-RXN]


Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate. [EC:3.5.1.33, RHEA:20593]


Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. [PMID:12024216, PMID:12486003]


formylaspartic formylase (formylase I, formylase II)

Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate. [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN]


Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate. [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN]


Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine. [EC:3.5.1.32, RHEA:10424]


Pseudomonas mandelamide hydrolase activity

Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+). [EC:3.5.1.86, RHEA:22876]


Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine. [EC:3.5.1.61, RHEA:13373]


Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H(2)O + H(+) = L-leucine + benzyl alcohol + CO(2). [EC:3.5.1.64, RHEA:18901]


Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate. [EC:3.5.1.56, RHEA:19517]


Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid. [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN]


N-acyl-D-amino acid amidohydrolase activity

Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid. [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN]


Catalysis of the reaction: N-acyl-D-aspartate + H(2)O = D-aspartate + a carboxylate. [EC:3.5.1.83, RHEA:18285]


Catalysis of the reaction: N-acyl-D-glutamate + H(2)O = D-glutamate + a carboxylate. [EC:3.5.1.82, RHEA:12833]


nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity

nalpha-carbobenzoxyamino acid amidohydrolase activity

Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine. [EC:3.5.1.58, RHEA:20900]


N-carbamoyl-D-amino acid amidohydrolase activity

N-carbamoyl-D-amino acid hydrolase activity

Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid. [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN]


N-carbamoyl-L-amino acid amidohydrolase activity

Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate. [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN]


Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine. [EC:3.5.1.53, RHEA:22284]


Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine. [EC:3.5.1.59, RHEA:20057]


Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine. [EC:3.5.1.71, RHEA:10484]


Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate. [EC:3.5.1.68, RHEA:12476]


Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate. [MetaCyc:3.5.1.27-RXN]


Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium. [EC:3.5.1.36, RHEA:24108]


Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]


valeramidase activity
pentanamide amidohydrolase activity

Catalysis of the reaction: H(2)O + pentanamide = NH(4)(+) + valerate. [EC:3.5.1.50, RHEA:10000]


formyl-L-methionyl peptide amidohydrolase activity

Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. [EC:3.5.1.88, GOC:jl]


Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3. [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN]


Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine. [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN]


Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3. [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN]


Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine. [EC:3.5.1.65, RHEA:18013]


Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+). [EC:3.5.1.57, RHEA:11012]


Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+). [EC:3.5.1.7, RHEA:14365]


Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+). [EC:3.5.1.75, RHEA:21372]


Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3. [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]


Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine. [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN]


Catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea. [EC:3.5.3.14, RHEA:14849]


Catalysis of the reaction: D-arginine + H(2)O = D-ornithine + urea. [EC:3.5.3.10, RHEA:12901]


Catalysis of the reaction: 1,4-diguanidinobutane + H(2)O = agmatine + urea. [EC:3.5.3.20, RHEA:13597]


Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3. [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN]


Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide. [EC:3.5.3.8, RHEA:22492]


Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3. [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN]


Catalysis of the reaction: guanidinoacetate + H(2)O = glycine + urea. [EC:3.5.3.2, RHEA:23268]


Catalysis of the reaction: 4-guanidinobutanoate + H(2)O = 4-aminobutanoate + urea. [EC:3.5.3.7, RHEA:19501]


GPH
guanidinopropionase activity
GPase activity

Catalysis of the reaction: 3-guanidinopropanoate + H(2)O = beta-alanine + urea. [EC:3.5.3.17, RHEA:16029]


methylenediurease activity
methylenediurea aminohydrolase activity

Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea. [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN, RHEA:15929]


Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea. [EC:3.5.3.16, RHEA:11764]


Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3. [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN]


Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+). [EC:3.5.5.4, RHEA:11188]


Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone. [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN]


Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+). [EC:3.5.99.5, RHEA:20996]


Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome. [EC:3.5.99.1, RHEA:11408]


Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+). [EC:3.5.99.2, RHEA:17509]


IAA-amino acid conjugate hydrolase activity

Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid. [GOC:tb]


Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine. [MetaCyc:RXN-2981]


Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid. [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN]


11-cis-retinol palmitate esterase activity

Catalysis of the reaction: 11-cis-retinyl palmitate + H(2)O = 11-cis-retinol + H(+) + palmitate. [EC:3.1.1.63, RHEA:19697]


Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H(+). [EC:3.1.1.57, RHEA:10644]


beta-ketoadipic enol-lactone hydrolase activity

3-oxoadipic enol-lactone hydrolase activity

beta-ketoadipate enol-lactone hydrolase activity

Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN]


Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H(2)O = H(+) + methanol + oxaloacetate. [EC:3.1.1.44, RHEA:10564]


Catalysis of the reaction: 4-pyridoxolactone + H(2)O = 4-pyridoxate + H(+). [EC:3.1.1.27, RHEA:14301]


diacetoxybutynylbithiophene acetate esterase activity

Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+). [EC:3.1.1.66, RHEA:16313]


Catalysis of the reaction: 6-acetyl-D-glucose + H(2)O = D-glucose + acetate + H(+). [EC:3.1.1.33, RHEA:18485]


Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+). [EC:3.1.1.54, RHEA:11548]


Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H(2)O = 1-alkyl-sn-glycerol + acetate + H(+). [EC:3.1.1.71, RHEA:11552]


Catalysis of the reaction: acetylsalicylate + H(2)O = acetate + H(+) + salicylate. [EC:3.1.1.55, RHEA:11752]


Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone. [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN]


high activity acylcarnitine hydrolase activity

long-chain acyl-L-carnitine hydrolase activity

Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine. [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN]


monoacylglycerolipase activity
monoglyceridase activity
fatty acyl monoester lipase activity
monoglyceride lipase activity
monoacylglycerol lipase activity
monoacylglycerol hydrolase activity
monoglyceride hydrolase activity
monoglyceridyllipase activity
glycerol-ester acylhydrolase activity

Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]


Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN]


alpha-amino-acid ester hydrolase activity

alpha-amino acid ester hydrolase activity

Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol. [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN]


Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+). [EC:3.1.1.60, RHEA:15529]


cephalosporin C acetyl-esterase activity

cephalosporin C acetyl-hydrolase activity

Catalysis of the reaction: cephalosporin C + H(2)O = acetate + deacetylcephalosporin C + H(+). [EC:3.1.1.41, RHEA:22596]


Catalysis of the reaction: benzyl cetraxate + H(2)O = benzyl alcohol + cetraxate + H(+). [EC:3.1.1.70, RHEA:23460]


chlorogenic acid esterase activity
chlorogenase activity

Catalysis of the reaction: chlorogenate + H(2)O = (-)-quinate + cis-caffeate + H(+). [EC:3.1.1.42, RHEA:20689]


Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide. [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN]


Catalysis of the reaction: cutin + H2O = cutin monomers. [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN]


Catalysis of the reaction: D-arabinono-1,4-lactone + H(2)O = D-arabinonate + H(+). [EC:3.1.1.30, RHEA:23108]


Catalysis of the reaction: deoxylimonoate + H(2)O = deoxylimononate D-ring-lactone + H(+). [EC:3.1.1.46, RHEA:14997]


Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+). [EC:3.1.1.35, RHEA:10360]


Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol. [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN]


Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN]


Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H(2)O = 2 (R)-3-hydroxybutanoate + H(+). [EC:3.1.1.22, RHEA:10172]


Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+). [EC:3.1.1.15, RHEA:16217]


Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+). [EC:3.1.1.65, RHEA:10288]


Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate. [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN]


calcium-dependent phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4]


calcium-independent phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. [EC:3.1.1.4]


calcium-dependent phospholipase C activity

Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+. [EC:3.1.4.3]


Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+). [EC:3.1.1.56, RHEA:12208]


N-acetyl galactosaminoglycan deacetylase activity

Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan. [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN]


Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+). [EC:3.1.1.40, RHEA:19549]


phorbol-12,13-diester 12-ester hydrolase activity

Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate. [EC:3.1.1.51, RHEA:21316]


phosphatidylinositol phospholipase A2 activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+). [EC:3.1.1.52, RHEA:18001]


Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5. [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN]


Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5. [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN]


polyneuridine aldehyde hydrolase (decarboxylating)

polyneuridine aldehyde esterase activity

Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol. [EC:3.1.1.78, RHEA:17501]


Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+. [RHEA:21508]


Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate. [EC:3.1.1.49, RHEA:10016]


Catalysis of the reaction: H(2)O + testololactone = H(+) + testolate. [EC:3.1.1.37, RHEA:13721]


tannin acetylhydrolase activity
tannin acylhydrolase activity

Catalysis of the reaction: digallate + H(2)O = 2 gallate + H(+). [EC:3.1.1.20, RHEA:16365]


triacetic acid lactone hydrolase activity

Catalysis of the reaction: H(2)O + triacetate lactone = triacetate. [EC:3.1.1.38, RHEA:22260]


atropinase activity
atropine esterase activity
atropinesterase activity
atropine acylhydrolase activity
tropine esterase activity

Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine. [EC:3.1.1.10, RHEA:23304]


Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate. [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN]


Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate. [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN]


Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate. [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN]


Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate. [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN]


Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate. [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN]


Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. [GOC:jid]


Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. [GOC:jid, PMID:10635319]


3' tRNA processing endoribonuclease activity

3'-tRNA processing endoribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. [PMID:12032089, PMID:21208191]


Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. [GOC:jl]


cyclic 3',5'-GMP phosphodiesterase activity

cyclic guanosine 3',5'-phosphate phosphodiesterase activity

3',5' cyclic-GMP phosphodiesterase activity

guanosine cyclic 3',5'-phosphate phosphodiesterase activity

cyclic guanosine 3',5'-monophosphate phosphodiesterase activity

Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957]


adenylyl-[glutamate-ammonia ligase] hydrolase activity

adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity

adenylyl-glutamate-ammonia ligase hydrolase activity

adenylyl(glutamine synthetase) hydrolase activity

Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]. [MetaCyc:3.1.4.15-RXN]


Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN]


cytidine monophosphate-N-acetylneuraminic acid hydrolase activity

cytidine monophosphosialate hydrolase activity

cytidine monophosphosialic hydrolase activity

CMP-N-acylneuraminic acid hydrolase activity

Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP. [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN]


calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity

calcium- and calmodulin-regulated cGMP phosphodiesterase activity

calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity

calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity

calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin. [GOC:jid]


dolichol phosphoglucose phosphodiesterase activity

Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose. [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN]


Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose. [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN]


Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate. [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN]


rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity

Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+). [EC:3.1.4.42, RHEA:16493]


Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+). [EC:3.1.4.38, RHEA:19545]


Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]


Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+). [EC:3.1.4.44, RHEA:16501]


D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity

D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity

D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity

Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol. [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN]


serine ethanolamine phosphodiester phosphodiesterase activity

Catalysis of the reaction: H(2)O + serine phosphoethanolamine = H(+) + phosphoethanolamine + serine. [EC:3.1.4.13, RHEA:17113]


sphingomyelin phosphodiesterase D activity

Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+). [EC:3.1.4.41, RHEA:20984]


2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity

Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H(2)O = 2-carboxy-D-arabinitol + phosphate. [EC:3.1.3.63, RHEA:17837]


Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate. [EC:3.1.3.71, RHEA:23416]


Catalysis of the reaction: 3-phospho-D-glycerate + H(2)O = D-glycerate + phosphate. [EC:3.1.3.38, RHEA:12412]


Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate. [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN]


adenosine diphosphate phosphoglycerate phosphatase activity

Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H(2)O = 3-ADP-glycerate + phosphate. [EC:3.1.3.28, RHEA:15861]


Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H(2)O = 2-acetyl-1-alkyl-sn-glycerol + phosphate. [EC:3.1.3.59, RHEA:18221]


smooth muscle caldesmon phosphatase activity

Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate. [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN]


Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate. [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN]


polyisoprenyl phosphate phosphatase activity

dolichyl pyrophosphate phosphatase activity

dolichyl monophosphate phosphatase activity

Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate. [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN]


Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate. [EC:3.1.3.54, RHEA:13333]


Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate. [EC:3.1.3.69, RHEA:22652]


Catalysis of the reaction: glycerol 2-phosphate + H(2)O = glycerol + phosphate. [EC:3.1.3.19, RHEA:13105]


Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H(2)O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate. [EC:3.1.3.40, RHEA:15777]


multiple inositol-polyphosphate phosphatase activity


Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. [GOC:jl]


Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate. [EC:3.1.3.22, RHEA:19537]


Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate. [EC:3.1.3.70, RHEA:19309]


Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H(2)O = S-methyl-1-thio-D-glycerate + phosphate. [EC:3.1.3.14, RHEA:16081]


myosin light chain kinase phosphatase activity

myosin light-chain kinase phosphatase activity

Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN]


N-acylneuraminic acid 9-phosphate phosphatase activity

N-acylneuraminic (sialic) acid 9-phosphatase activity

Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]


Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate. [GOC:ai]


Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate. [GOC:ai]


Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate. [EC:3.1.3.60, RHEA:19997]


Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate. [EC:3.1.3.20, RHEA:21156]


sedoheptulose 1,7-diphosphate phosphatase activity

Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate. [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN]


Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate. [EC:3.1.3.50, RHEA:24580]


streptomycin 6-phosphate phosphohydrolase activity

streptomycin 6-phosphate phosphatase activity

Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin. [EC:3.1.3.39, RHEA:10688]


Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN]


Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate. [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN]


Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate. [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN]


3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity

3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity

branched-chain alpha-keto acid dehydrogenase phosphatase

branched-chain 2-keto acid dehydrogenase phosphatase activity

branched-chain oxo-acid dehydrogenase phosphatase activity

[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity

Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]. [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN]


acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity

Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate. [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN]


UDP-glycogen glucosyltransferase phosphatase activity

UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity

UDPglucose-glycogen glucosyltransferase phosphatase activity

glycogen synthase D phosphatase activity

Mg2+ dependent glycogen synthase phosphatase activity

uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity

UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity

glycogen synthetase phosphatase activity

Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate. [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN]


hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity

hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity

[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity

Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]. [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN]


phosphorylase a phosphohydrolase activity

glycogen phosphorylase phosphatase activity

Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate. [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN]


ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity

Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate. [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN]


diisopropyl phosphorofluoridate hydrolase activity

organophosphorus acid anhydrolase activity

Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride. [EC:3.1.8.2, RHEA:24100]


choline-sulfate sulfohydrolase activity
choline-sulphatase activity

Catalysis of the reaction: choline sulfate + H(2)O = choline + H(+) + sulfate. [EC:3.1.6.6, RHEA:20820]


Catalysis of the reaction: (R)-2-O-sulfolactate + H(2)O = (R)-lactate + H(+) + sulfate. [EC:3.1.6.17, RHEA:20337]


Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate. [EC:3.1.6.11, RHEA:15517]


glucosulfatase activity
sugar-sulfate sulfohydrolase activity
glycosulphatase activity

Catalysis of the reaction: D-glucose 6-sulfate + H(2)O = D-glucose + H(+) + sulfate. [EC:3.1.6.3, RHEA:19145]


Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate. [EC:3.1.6.16, RHEA:14221]


D-methylmalonyl-coenzyme A hydrolase activity

Catalysis of the reaction: (S)-methylmalonyl-CoA + H(2)O = CoA + H(+) + methylmalonate. [EC:3.1.2.17, RHEA:17345]


acetoacetyl coenzyme A deacylase activity

acetoacetyl coenzyme A hydrolase activity

Catalysis of the reaction: acetoacetyl-CoA + H(2)O = acetoacetate + CoA + H(+). [EC:3.1.2.11, RHEA:15673]


acyl-CoA thioesterase activity
acyl coenzyme A hydrolase activity
acyl-CoA thiolesterase activity
acyl coenzyme A thioesterase activity

Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. [RHEA:16781]


acyl-[acyl-carrier protein] hydrolase activity

S-acyl fatty acid synthase thioesterase activity

acyl-acyl carrier protein hydrolase activity

Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid. [EC:3.1.2.14, MetaCyc:RXN-7902]


lauryl-[acyl-carrier protein] hydrolase activity

dodecanoyl-[acyl-carrier protein] hydrolase activity

lauryl-acyl-carrier protein hydrolase activity

dodecyl-[acyl-carrier protein] hydrolase activity

Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]. [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN]


ADP-dependent medium-chain hydrolase activity

ADP-dependent medium-chain acyl-thioester hydrolase activity

ADP-dependent medium-chain acyl-CoA hydrolase activity

ADP-dependent medium-chain acyl coenzyme A hydrolase activity

ADP-dependent medium-chain-acyl-CoA hydrolase activity

Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP. [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN]


ADP-dependent short-chain acyl-CoA thioesterase activity

ADP-dependent short-chain acyl-CoA hydrolase activity

ADP-dependent short-chain acyl coenzyme A hydrolase activity

ADP-dependent short-chain-acyl-CoA hydrolase activity

Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA. [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN]


Catalysis of the reaction: formyl-CoA + H(2)O = CoA + formate + H(+). [EC:3.1.2.10, RHEA:19741]


Catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+). [EC:3.1.2.7, RHEA:22708]


hydroxymethylglutaryl coenzyme A deacylase activity

hydroxymethylglutaryl coenzyme A hydrolase activity

beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity

beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity

Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = 3-hydroxy-3-methylglutarate + CoA + H(+). [EC:3.1.2.5, RHEA:16305]


Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate. [EC:3.1.2.13, RHEA:16713]


citrate (pro-3S)-lyase thiolesterase activity

Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate. [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN]


Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde. [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN]


Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde. [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN]


Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN]


Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate. [EC:3.3.2.4, RHEA:20740]


S-adenosylmethionine cleaving enzyme activity

Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O = S-methyl-5'-thioadenosine + L-homoserine + H(+). [EC:3.3.1.2, RHEA:14645]


Catalysis of the reaction: 1-methyladenosine + H(2)O = 1-methyladenine + ribofuranose. [EC:3.2.2.13, RHEA:12865]


adenosine ribohydrolase activity
adenosinase activity
adenosine hydrolase activity
N-ribosyladenine ribohydrolase activity
ANase activity

Catalysis of the reaction: adenosine + H2O = D-ribose + adenine. [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN]


dinitrogenase reductase activating glycohydrolase activity

ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity

dinitrogenase reductase-activating glycohydrolase activity

ADP-ribosyl-dinitrogen reductase hydrolase activity

ADP-ribosyl-[dinitrogen reductase] hydrolase activity

Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]. [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN]


Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-D-glucosamine + L-asparagine. [EC:3.2.2.11, RHEA:12324]


Catalysis of the reaction: H(2)O + IMP = D-ribose 5-phosphate + hypoxanthine. [EC:3.2.2.12, RHEA:20469]


inosine-guanosine nucleosidase activity
inosinase activity
inosine ribohydrolase activity

Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine. [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN]


nicotinamide adenine dinucleotide (phosphate) nucleosidase activity

nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity

Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide. [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN]


pyrimidine nucleotide N-ribosidase activity

Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine. [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN]


Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine. [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN]


Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside. [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN]


Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol. [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN]


Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide. [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN]


Catalysis of the reaction: (R)-amygdalin + H(2)O = (R)-prunasin + D-glucose. [EC:3.2.1.117, RHEA:14177]


Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans. [EC:3.2.1.99]


Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol. [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN]


Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol. [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN]


Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol. [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN]


Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin. [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN]


bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity

Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose. [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN]


Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose. [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN]


Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate. [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN]


guanosine diphosphate D-glucose glucohydrolase activity

Catalysis of the reaction: GDP-D-glucose + H(2)O = D-glucose + GDP + H(+). [EC:3.2.1.42, RHEA:15049]


Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans. [EC:3.2.1.39]


Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine. [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN]


Catalysis of the reaction: glycyrrhizate + H(2)O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate. [EC:3.2.1.128, RHEA:17369]


Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc. [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN]


beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity

glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group

Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds. [EC:3.2.1.73]


Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate. [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN]


Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine. [MetaCyc:3.2.1.110-RXN]


Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins. [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN]


prunasin b-glucosidase activity
prunasin beta-D-glucohydrolase activity
prunasin hydrolase activity

Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile. [EC:3.2.1.118, RHEA:16489]


Catalysis of the reaction: H(2)O + quercitrin = L-rhamnose + quercetin. [EC:3.2.1.66, RHEA:17465]


Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine. [EC:3.2.1.125, RHEA:14557]


Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol. [EC:3.2.1.104, RHEA:11956]


Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone. [EC:3.2.1.105, RHEA:12917]


Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose. [EC:3.2.1.119, RHEA:14041]


OBSOLETE. Catalysis of the hydrolysis of elastin. [ISBN:0198506732]


Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide. [EC:5.2.1.10, RHEA:10924]


Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime. [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN]


Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol. [EC:5.2.1.9, RHEA:13401]


Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide. [EC:5.2.1.6, RHEA:21848]


Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate. [EC:5.2.1.5, RHEA:17381]


Catalysis of the reaction: maleate = fumarate. [EC:5.2.1.1, RHEA:13169]


Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate. [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN]


Catalysis of the reaction: all-trans-retinol = 11-cis-retinol. [GOC:pde, RHEA:19141]


Catalysis of the reaction: D-lyxose = D-xylulose. [EC:5.3.1.15, RHEA:14201]


Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate. [EC:5.3.1.26, RHEA:13033]


Catalysis of the reaction: D-mannose = D-fructose. [EC:5.3.1.7, RHEA:22604]


Catalysis of the reaction: ribofuranose = D-ribulose. [EC:5.3.1.20, RHEA:20796]


oxaloacetate keto-enol tautomerase activity

Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate. [EC:5.3.2.2, RHEA:16021]


phenylpyruvate keto--enol tautomerase activity

phenylpyruvic keto--enol isomerase activity

Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. [RHEA:17097]


prostaglandin R-prostaglandin E isomerase activity

prostaglandin endoperoxide E isomerase activity

prostaglandin endoperoxide E2 isomerase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). [EC:5.3.99.3, RHEA:12893]


Catalysis of the reaction: trans-aconitate = cis-aconitate. [RHEA:17265]


Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. [RHEA:15281]


Catalysis of the reaction: isopiperitenone = piperitenone. [RHEA:21516]


Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate. [RHEA:23480]


Catalysis of the reaction: prostaglandin A1 = prostaglandin C1. [RHEA:10460]


vinylacetyl coenzyme A isomerase activity

vinylacetyl coenzyme A delta-isomerase activity

Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA. [RHEA:10572]


beta-carboxymuconate lactonizing enzyme activity

3-carboxymuconate lactonizing enzyme activity

Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+). [PMID:15301541, PMID:17054713, RHEA:23656]


3-carboxy-cis,cis-muconate lactonizing enzyme activity

Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate. [EC:5.5.1.5, RHEA:14977]


Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate. [EC:5.5.1.12, RHEA:24316]


Catalysis of the reaction: cycloeucalenol = obtusifoliol. [EC:5.5.1.9, RHEA:22800]


bornyl pyrophosphate synthetase activity

Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate. [EC:5.5.1.8, RHEA:18209]


Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate. [EC:5.5.1.3, RHEA:18097]


Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate. [EC:5.4.2.9, RHEA:17013]


Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor. [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN]


Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. [PMID:7559556]


Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine. [EC:5.4.1.1, RHEA:24356]


Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate. [EC:5.4.3.3, RHEA:21736]


adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity

Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate. [EC:5.4.3.4, RHEA:18241]


Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate. [EC:5.4.3.5, RHEA:14893]


Catalysis of the reaction: L-leucine = (3R)-beta-leucine. [EC:5.4.3.7, RHEA:10284]


Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate. [EC:5.4.3.2, RHEA:19177]


tyrosine alpha,beta-mutase activity
L-tyrosine 2,3-aminomutase activity

Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate. [EC:5.4.3.6, RHEA:15781]


intramolecular transferase activity, transferring hydroxy groups

Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule. [GOC:mah]


Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside. [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN]


2-acetolactate methylmutase activity
acetolactate mutase activity

Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate. [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN]


Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate. [EC:5.4.99.4, RHEA:13793]


4-methyl-3-enelactone methyl isomerase activity

Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide. [EC:5.4.99.14, RHEA:19237]


Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA. [EC:5.4.99.13, RHEA:13141]


Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose. [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN]


maltose glucosylmutase activity
trehalose synthase activity
maltose alpha-D-glucosylmutase activity

Catalysis of the reaction: maltose = trehalose. [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN]


Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate. [EC:5.4.99.1, RHEA:12857]


Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [GOC:mah]


isothiocyanate isomerase activity
benzyl-thiocyanate isomerase activity

Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate. [EC:5.99.1.1, RHEA:10004]


Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam. [EC:5.1.1.15, RHEA:14813]


hydroxyproline epimerase activity
hydroxyproline 2-epimerase activity
L-hydroxyproline epimerase activity
4-hydroxyproline 2-epimerase activity

Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline. [EC:5.1.1.8, RHEA:21152]


Catalysis of the reaction: an L-amino acid = a D-amino acid. [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN]


Catalysis of the reaction: L-arginine = D-arginine. [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN]


Catalysis of the reaction: L-aspartate = D-aspartate. [EC:5.1.1.13, RHEA:14973]


Catalysis of the reaction: isonocardicin A = nocardicin A. [EC:5.1.1.14, RHEA:22792]


Catalysis of the reaction: L-ornithine = D-ornithine. [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN]


phenylalanine racemase (adenosine triphosphate-hydrolysing)

phenylalanine racemase (ATP-hydrolyzing) activity

Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+). [EC:5.1.1.11, RHEA:20201]


cytidine diphosphoabequose epimerase activity

cytidine diphosphoparatose epimerase activity

cytidine diphosphodideoxyglucose epimerase activity

cytidine diphosphate paratose-2-epimerase activity

Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose. [EC:5.1.3.10, RHEA:21656]


Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose. [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN]


chondroitin D-glucuronosyl 5-epimerase activity

Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate. [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN]


guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity

Catalysis of the reaction: GDP-mannose = GDP-L-galactose. [EC:5.1.3.18]


glucose-6 phosphate 1-epimerase activity

Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN]


Catalysis of the reaction: alpha-maltose = beta-maltose. [EC:5.1.3.21, RHEA:21228]


Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine. [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN]


acylglucosamine phosphate 2-epimerase activity

acylmannosamine phosphate 2-epimerase activity

N-acetylglucosmamine 6-phosphate 2-epimerase activity

Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN]


uridine diphosphoarabinose epimerase activity

uridine 5'-diphosphate-D-xylose 4-epimerase activity

Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose. [EC:5.1.3.5, RHEA:11320]


UDPglucosamine 4-epimerase activity
UDP-glucosamine epimerase activity

Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine. [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN]


uridine diphosphoglucuronate epimerase activity

UDP-D-galacturonic acid 4-epimerase activity

uridine diphosphoglucuronic epimerase activity

Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate. [EC:5.1.3.6, RHEA:11404]


uridine diphosphoglucuronate 5'-epimerase activity

UDP-glucuronic acid 5'-epimerase activity

Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]


Catalysis of the reaction: (S)-acetoin = (R)-acetoin. [EC:5.1.2.4, RHEA:12092]


Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate. [EC:5.1.2.6, RHEA:10820]


lactic acid racemase activity
hydroxyacid racemase activity
lacticoracemase activity

Catalysis of the reaction: (S)-lactate = (R)-lactate. [EC:5.1.2.1, RHEA:10960]


Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate. [EC:5.1.2.5, RHEA:22212]


Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid. [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN]


Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin. [EC:5.1.99.3, RHEA:10804]


Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. [GOC:bf, PMID:10209156, PMID:9255069]


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). [EC:2.7.1.153, RHEA:21292]


reduced diphosphopyridine nucleotide kinase activity

reduced nicotinamide adenine dinucleotide kinase (phosphorylating)

Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH. [EC:2.7.1.86, RHEA:12260]


nucleoside triphosphate-adenosine monophosphate transphosphorylase activity

nucleoside triphosphate adenylate kinase activity

Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. [EC:2.7.4.10]


JUN kinase kinase kinase kinase activity

Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs). [GOC:bf]


geranoyl coenzyme A carboxylase activity

Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate. [EC:6.4.1.5, RHEA:17701]


beta-methylcrotonyl coenzyme A carboxylase activity

beta-methylcrotonyl CoA carboxylase activity

Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate. [EC:6.4.1.4, RHEA:13589]


Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH(4)(+) = 4-methylene-L-glutamine + AMP + diphosphate + 2 H(+). [EC:6.3.1.7, RHEA:13853]


asparagine synthetase (adenosine diphosphate-forming)

asparagine synthetase (ADP-forming) activity

aspartate-ammonia ligase (ADP-forming) activity

Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate. [EC:6.3.1.4, RHEA:14197]


Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H(+) + phosphate. [EC:6.3.1.6, RHEA:20525]


nicotinamide adenine dinucleotide synthetase activity

diphosphopyridine nucleotide synthetase activity

Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. [EC:6.3.1.5]


Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate. [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN]


Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine. [EC:6.3.2.14, MetaCyc:1,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN]


Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate. [RHEA:11760]


Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN]


D-alanine [D-alanyl carrier protein] ligase activity

D-alanine-D-alanyl carrier protein ligase activity

Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP. [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN]


Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown. [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN]


beta-alanine specific hGSH synthetase activity

Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H(+) + phosphate. [EC:6.3.2.23, RHEA:17993]


Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H(+) + phosphate. [EC:6.3.2.20, RHEA:14857]


L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)

Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+). [EC:6.3.2.26, RHEA:23196]


4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity

5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity

4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity

Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. [EC:6.3.2.6, RHEA:22628]


Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+). [EC:6.3.2.24, RHEA:15345]


uridine diphosphate N-acetylmuramate:L-alanine ligase activity

uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity

uridine diphospho-N-acetylmuramoylalanine synthetase activity

Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine. [EC:6.3.2.8, RHEA:23372]


uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity

Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine. [EC:6.3.2.7, RHEA:17969]


uridine diphosphoacetylmuramoylpentapeptide synthetase activity

Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN]


asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP. [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN]


Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H(+) + phosphate. [EC:6.3.4.17, RHEA:24328]


Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H(+) + phosphate. [EC:6.3.4.12, RHEA:17117]


imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)

Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H(+) + phosphate. [EC:6.3.4.8, RHEA:16485]


ammonia-ribose 5-phosphate aminotransferase activity

Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate. [EC:6.3.4.7, RHEA:13777]


Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP. [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN]


Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP. [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN]


L-lysine:tRNAPyl ligase (AMP-forming)
lysine-tRNAPyl ligase activity

Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP. [MetaCyc:6.1.1.25-RXN]


2-furoate:CoA ligase (AMP-forming)
2-furoyl coenzyme A synthetase activity

Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H(+). [EC:6.2.1.31, RHEA:19269]


3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity

Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP. [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN]


acetoacetyl-CoA synthetase activity
acetoacetate:CoA ligase (AMP-forming)

Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+). [EC:6.2.1.16, RHEA:16117]


acyl-CoA synthetase (GDP-forming) activity

acyl coenzyme A synthetase (guanosine diphosphate forming)

Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H(+) + phosphate. [RHEA:10968]


arachidonate:CoA ligase (AMP-forming)
arachidonoyl-CoA synthetase activity

Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). [RHEA:19713]


biotin CoA synthetase activity
biotinyl-CoA synthetase activity
biotin:CoA ligase (AMP-forming)
biotinyl coenzyme A synthetase activity

Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA. [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN]


L-(+)-3-hydroxybutyryl CoA ligase activity

short-chain acyl-CoA synthetase activity

fatty acyl coenzyme A synthetase activity

medium chain acyl-CoA synthetase activity

fatty acid thiokinase (medium chain) activity

Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA. [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN]


3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity

Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. [EC:6.2.1.7]


citrate thiokinase activity
citryl-CoA synthetase activity
citrate:CoA ligase activity
citrate:CoA ligase (ADP-forming)

Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H(+) + phosphate. [EC:6.2.1.18, RHEA:21472]


Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA. [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN]


glutaryl-CoA synthetase activity
glutaryl coenzyme A synthetase activity
glutarate:CoA ligase (ADP-forming)

Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H(+) + phosphate. [EC:6.2.1.6, RHEA:14169]


malate:CoA ligase (ADP-forming)
malyl-CoA synthetase activity
malyl coenzyme A synthetase activity

Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA. [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN]


oxalyl coenzyme A synthetase activity
oxalyl-CoA synthetase activity
oxalate:CoA ligase (AMP-forming)

Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA. [RHEA:18293]


phenylacetyl-CoA ligase activity
phenylacetyl-CoA ligase (AMP-forming)
phenacyl coenzyme A synthetase activity
phenylacetate:CoA ligase (AMP-forming)
PA-CoA ligase activity

Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA. [EC:6.2.1.30, RHEA:20956]


phytanate:CoA ligase (AMP-forming)
phytanoyl-CoA ligase activity

Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA. [EC:6.2.1.24, RHEA:21380]


propionyl-CoA synthetase activity
propanoate:CoA ligase (AMP-forming)

Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA. [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN]


Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate. [PMID:22649270]


Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN]


Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate. [EC:4.1.2.28, RHEA:20609]


Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate. [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN]


Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde. [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN]


Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate. [EC:4.1.2.23, RHEA:23340]


Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate. [EC:4.1.2.29, RHEA:13177]


2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)

2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity

2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity

Catalysis of the reaction: benzoin = 2 benzaldehyde. [EC:4.1.2.38, RHEA:21460]


Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde. [EC:4.1.2.24, RHEA:19321]


D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity

D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)

Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O. [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN]


Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol. [EC:4.1.2.33, RHEA:10884]


Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate. [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN]


Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone. [GOC:mah, PMID:3377504]


Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate. [EC:4.1.2.2, RHEA:20932]


Catalysis of the reaction: (S)-lactate = acetaldehyde + formate. [EC:4.1.2.36, RHEA:17909]


Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine. [EC:4.1.2.26, RHEA:21712]


D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)

D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity

Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN]


Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal. [EC:4.1.2.35, RHEA:11100]


trimethylamine N-oxide formaldehyde-lyase activity

trimethylamine N-oxide aldolase activity

trimethylamine N-oxide demethylase activity

Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde. [EC:4.1.2.32, RHEA:20217]


Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin. [RHEA:18725]


Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. [EC:4.1.3.39, RHEA:22624]

4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity


alpha-dialkyl amino acid transaminase activity

2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)

dialkyl amino acid (pyruvate) decarboxylase activity

2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity

2,2-dialkylglycine decarboxylase (pyruvate) activity

Catalysis of the reaction: 2,2-dialkylglycine + H(+) + pyruvate = L-alanine + CO(2) + dialkyl ketone. [EC:4.1.1.64, RHEA:16073]


Catalysis of the reaction: 3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO(2). [EC:4.1.1.69, RHEA:18601]


Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 5-hydroxy-6-methylpyridine-3-carboxylate + CO(2). [EC:4.1.1.51, RHEA:13669]


Catalysis of the reaction: 3-oxolaurate + H(+) = 2-undecanone + CO(2). [EC:4.1.1.56, RHEA:13385]


Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2). [EC:4.1.1.44, RHEA:23348]


Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2). [EC:4.1.1.80, RHEA:18697]


Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate. [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN]


2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity

Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2). [EC:4.1.1.75, RHEA:11340]


6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity

Catalysis of the reaction: 6-methylsalicylate + H(+) = 3-cresol + CO(2). [EC:4.1.1.52, RHEA:23112]


Catalysis of the reaction: acetoacetate + H(+) = acetone + CO(2). [EC:4.1.1.4, RHEA:19729]


Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2. [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN]


Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate. [EC:4.1.1.78]


cis-aconitic decarboxylase activity
cis-aconitate carboxy-lyase activity
aconitate decarboxylase activity
CAD activity

Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate. [EC:4.1.1.6, RHEA:15253]


Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2. [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN]


Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2). [EC:4.1.1.45, RHEA:16557]


Catalysis of the reaction: 2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO(2). [EC:4.1.1.76, RHEA:20513]


L-cysteine sulfinate acid desulfinase activity

Catalysis of the reaction: L-aspartate = L-alanine + CO2. [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN]


Catalysis of the reaction: benzoylformate = benzaldehyde + CO2. [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN]


branched-chain keto acid decarboxylase activity

branched-chain alpha-keto acid decarboxylase activity

branched-chain oxo acid decarboxylase activity

Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2). [EC:4.1.1.72, RHEA:21108]


Catalysis of the reaction: carnitine + H(+) = 2-methylcholine + CO(2). [EC:4.1.1.42, RHEA:21576]


Catalysis of the reaction: 3-dehydro-L-gulonate + H(+) = L-xylulose + CO(2). [EC:4.1.1.34, RHEA:11084]


Catalysis of the reaction: dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2). [EC:4.1.1.54, RHEA:13845]


Catalysis of the reaction: 2,5-dihydroxybenzoate + H(+) = CO(2) + hydroquinone. [EC:4.1.1.62, RHEA:21312]


Catalysis of the reaction: 3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO(2). [EC:4.1.1.16, RHEA:14073]


Catalysis of the reaction: 3-hydroxypyruvate + H(+) = CO(2) + glycolaldehyde. [EC:4.1.1.40, RHEA:20561]


Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde. [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN]


malonyl coenzyme A decarboxylase activity

Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]


Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2). [EC:4.1.1.57, RHEA:17757]


Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2). [EC:4.1.1.46, RHEA:21492]

2,3-dihydroxybenzoic acid decarboxylase activity


Catalysis of the reaction: o-orsellinate + H(+) = CO(2) + orcinol. [EC:4.1.1.58, RHEA:16733]


Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2). [EC:4.1.1.30, RHEA:15077]


Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2. [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN]


Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2). [EC:4.1.1.63, RHEA:22416]


stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)

Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate. [EC:4.1.1.60, RHEA:13885]


Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde. [EC:4.1.1.79, RHEA:20948]


Catalysis of the reaction: L-tartrate + H(+) = D-glycerate + CO(2). [EC:4.1.1.73, RHEA:13317]


UDP-galacturonic acid decarboxylase activity

Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose. [EC:4.1.1.67, RHEA:19725]


UDP-glucuronic acid decarboxylase activity

Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose. [EC:4.1.1.35, RHEA:23916]


uracil-5-carboxylic acid decarboxylase activity

Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil. [EC:4.1.1.66, RHEA:17685]


Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2). [EC:4.1.1.14, RHEA:18989]


L-tyrosine phenol-lyase (deaminating; pyruvate-forming)

Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate. [EC:4.1.99.2, RHEA:21704]


Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone. [EC:4.1.3.35, RHEA:23868]


Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate. [EC:4.1.3.32, RHEA:10472]


3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity

Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H(+) = 7-methyl-3-oxooct-6-enoyl-CoA + acetate. [EC:4.1.3.26, RHEA:23084]


Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate. [EC:4.1.3.14, RHEA:14377]


Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. [EC:2.6.1.85, RHEA:11672]


Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN]


Catalysis of the reaction: S-citramalate = acetate + pyruvate. [EC:4.1.3.22, RHEA:15545]


Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate. [EC:4.1.3.25, RHEA:22612]


Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate. [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN]


Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate. [EC:4.1.3.13, RHEA:22032]


L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)

Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H(2)O = 2-oxopent-4-enoate + chloride + H(+) + NH(4)(+). [EC:4.5.1.4, RHEA:11620]


3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)

3-chloro-L-alanine chloride-lyase (adding thioglycolate)

Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+). [EC:4.5.1.5, RHEA:22868]


DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)

DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)

Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O. [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN]


Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. [EC:4.3.2.3, RHEA:11304]


3-ketovalidoxylamine A C-N-lyase activity

p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity

Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H(+). [EC:4.3.3.1, RHEA:22768]