non-chaperonin molecular chaperone ATPase activity

OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin. [EC:3.6.4.10]


OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle. [EC:3.6.4.7]


hydrolase activity, acting on acid carbon-carbon bonds

Catalysis of the hydrolysis of any acid carbon-carbon bond. [GOC:jl]


hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. [GOC:ai]


2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity

Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate. [RHEA:24789]


Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate. [UM-BBD_reactionID:r0458]


Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate. [EC:3.7.1.8]


Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate. [UM-BBD_reactionID:r0399]


Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate. [UM-BBD_reactionID:r0263]


Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate. [UM-BBD_reactionID:r0311]


2-hydroxymuconic semialdehyde hydrolase activity

Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate. [EC:3.7.1.9]


Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+. [UM-BBD_reactionID:r0444]


Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate. [EC:3.7.1.6, RHEA:16097]


Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate. [UM-BBD_reactionID:r0008]


fumarylacetoacetase activity
fumarylacetoacetate hydrolase activity
beta-diketonase activity

Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). [EC:3.7.1.2, RHEA:10244]


kynurenine hydrolase activity
L-kynurenine hydrolase activity

Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. [EC:3.7.1.3]


oxalacetic hydrolase activity
oxaloacetase activity

Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate. [EC:3.7.1.1, RHEA:24432]


Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate. [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094]


hydrolase activity, acting on acid carbon-phosphorus bonds

Catalysis of the hydrolysis of any acid carbon-phosphorus bond. [GOC:jl]


hydrolase activity, acting on acid halide bonds

Catalysis of the hydrolysis of any acid halide bond. [GOC:jl]


hydrolase activity, acting on acid halide bonds, in C-halide compounds

Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage. [ISBN:0198506732]


Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol). [PMID:10464214]


halocarboxylic acid halidohydrolase activity

2-haloalkanoic acid dehalogenase activity

2-halocarboxylic acid dehalogenase II activity

2-haloalkanoid acid halidohydrolase activity

Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. [EC:3.8.1.2]


4-chlorobenzoyl CoA chlorohydrolase activity

Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride. [EC:3.8.1.7]


Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+). [EC:3.8.1.8, RHEA:11312]


cis-chloroacrylic acid dehalogenase activity

Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde. [UM-BBD_reactionID:r0688]


Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3. [UM-BBD_reactionID:0129]


Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate. [UM-BBD_reactionID:r0383]


haloacetate halidohydrolase activity
haloacetate dehalogenase activity

Catalysis of the reaction: haloacetate + H2O = glycolate + halide. [EC:3.8.1.3]


1-haloalkane halidohydrolase activity
haloalkane dehalogenase activity
1-haloalkane dehalogenase activity

Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide. [PMID:3624201, RHEA:19081]


Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine. [UM-BBD_ruleID:bt0330]


iodothyronine outer ring monodeiodinase activity

L-thyroxine iodohydrolase (reducing) activity

Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. [EC:1.21.99.4]


trans-chloroacrylic acid dehalogenase activity

Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde. [UM-BBD_reactionID:r0689]


hydrolase activity, acting on acid phosphorus-nitrogen bonds

Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond. [GOC:jl]


hydrolase activity, acting on acid sulphur-nitrogen bonds

hydrolase activity, acting on acid sulfur-nitrogen bonds

Catalysis of the hydrolysis of any acid sulfur-nitrogen bond. [GOC:jl]


Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate. [EC:3.10.1.2, RHEA:18481]


2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)

Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate. [EC:3.10.1.1]


hydrolase activity, acting on acid sulphur-sulphur bonds

hydrolase activity, acting on acid sulfur-sulfur bonds

Catalysis of the hydrolysis of any acid sulfur-sulfur bond. [GOC:jl]


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. [GOC:jl]


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. [GOC:ai]


Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate. [UM-BBD_reactionID:r0707]


Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate. [EC:3.5.2.9, RHEA:10348]


Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate. [EC:3.5.2.12, RHEA:16225]


Catalysis of the reaction: allantoin + H2O = allantoate. [EC:3.5.2.5]


Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2. [EC:3.5.2.15]


Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+). [EC:3.5.2.3, RHEA:24296]


Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. [EC:3.5.2.2]


Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate. [UM-BBD_reactionID:r0448]


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. [ISBN:0198506732]


Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. [GOC:mah]


Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators]


dihydroneopterin triphosphate synthase activity

guanosine triphosphate cyclohydrolase activity

guanosine triphosphate 8-deformylase activity

Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. [EC:3.5.4.16]


guanosine triphosphate cyclohydrolase II

Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+). [EC:3.5.4.25, RHEA:23704]


IMP synthetase activity
inosinicase activity
inosinate cyclohydrolase activity
IMP 1,2-hydrolase (decyclizing)

Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. [EC:3.5.4.10]


citrovorum factor cyclodehydrase activity

Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. [EC:3.5.4.9]


Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+). [EC:3.5.4.27, RHEA:19053]


Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. [EC:3.5.4.19, RHEA:20049]

phosphoribosyladenosine monophosphate cyclohydrolase activity


Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R). [GOC:jl]


ADase activity
adenase activity
adenine aminohydrolase activity
adenine deaminase activity

Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3. [EC:3.5.4.2]


adenosine deaminase activity
adenosine aminohydrolase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3. [EC:3.5.4.4]


tRNA-specific adenosine deaminase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. [GOC:mah]


adenosine 5-monophosphate deaminase activity

adenosine monophosphate deaminase activity

adenosine 5-phosphate aminohydrolase activity

Catalysis of the reaction: AMP + H2O = IMP + NH3. [EC:3.5.4.6]


cytidine deaminase activity
cytosine nucleoside deaminase activity

Catalysis of the reaction: cytidine + H2O = uridine + NH3. [EC:3.5.4.5]


cytosine aminohydrolase activity
cytosine deaminase activity

Catalysis of the reaction: cytosine + H2O = uracil + NH3. [EC:3.5.4.1]


deoxycytidine monophosphate deaminase activity

Catalysis of the reaction: dCMP + H2O = dUMP + NH3. [EC:3.5.4.12]


deoxycytidine triphosphate deaminase activity

Catalysis of the reaction: dCTP + H2O = dUTP + NH3. [EC:3.5.4.13]


2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity

Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+). [EC:3.5.4.26, RHEA:21868]


guanase activity
guanine aminase activity
GAH activity
guanine deaminase activity

Catalysis of the reaction: guanine + H2O = xanthine + NH3. [EC:3.5.4.3]


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. [GOC:ai]


Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine. [UM-BBD_reactionID:r0708]


6-aminohexanoic acid oligomer hydrolase activity

Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate. [EC:3.5.1.46]


allophanate lyase activity
allophanate hydrolase activity

Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+). [EC:3.5.1.54, RHEA:19029]


acylase activity
acetamidase activity
amidohydrolase activity
N-acetylaminohydrolase activity
fatty acylamidase activity
acylamidase activity
acylamide amidohydrolase activity

Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. [EC:3.5.1.4]


Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. [EC:3.5.1.14]


kynurenine formamidase activity
formylase activity
arylformamidase activity
formylkynureninase activity
formylkynurenine formamidase activity

Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. [EC:3.5.1.9]


asparaginase activity
leunase activity
elspar
L-asparaginase activity
L-asparagine amidohydrolase activity
colaspase activity

Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. [EC:3.5.1.1]


Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+). [EC:3.5.1.26, RHEA:11544]


protein-N-terminal asparagine amidohydrolase activity

Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein. [PMID:8910481]


Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. [EC:3.5.1.15]


Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. [EC:3.5.1.6]


Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3. [EC:3.5.1.84]


Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid. [EC:3.5.1.23, GOC:pz]


Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. [EC:3.2.1.46]


trihexosyl ceramide galactosidase activity

Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose. [EC:3.2.1.47]


Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. [EC:3.2.1.45]


glycosyl ceramide glycosylhydrolase activity

Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. [PMID:10692580, PMID:9762914]


Catalysis of the reaction: chitin + H2O = chitosan + acetate. [EC:3.5.1.41]


Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine. [EC:3.5.1.24]


Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. [GOC:jl]


Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine. [EC:3.5.1.16]


Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. [EC:3.5.1.25]

acetylglucosamine phosphate deacetylase activity


UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity

Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. [PMID:10026271]


Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. [PMID:15952893]


formamide amidohydrolase activity
formamide hydrolase activity

Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+). [EC:3.5.1.49, RHEA:21948]


Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate. [EC:3.5.1.31, RHEA:17781]


Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+). [EC:3.5.1.10, RHEA:19833]


glutaminase activity
L-glutamine amidohydrolase activity
glutamine aminohydrolase activity

Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. [EC:3.5.1.2]


cobyrinate a c-diamide synthase activity

cobyrinate a,c-diamide synthase activity

cobyrinate a c diamide synthase activity

cobyrinate a,c diamide synthase activity

cobyrinic acid a,c-diamide synthase activity

Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide. [PMID:2172209, RHEA:26289]


glutathionylspermidine amidohydrolase (spermidine-forming) activity

Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine. [EC:3.5.1.78]


Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate. [UM-BBD_reactionID:r0706]


Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. [EC:3.5.1.28, PMID:22748813]

N-acetylmuramic acid L-alanine amidase activity


nicotinamide amidase activity
nicotinamide amidohydrolase activity
NAMase activity
YNDase activity
nicotinamide deaminase activity
nicotine deamidase activity

Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3. [EC:3.5.1.19]


nicotinamide mononucleotide amidohydrolase activity

nicotinamide mononucleotide deamidase activity

Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3. [EC:3.5.1.42]


pantetheine hydrolase activity
(R)-pantetheine amidohydrolase activity
vanin-1
pantetheinase activity

Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine. [EC:3.5.1.92, RHEA:13445]


pantothenate amidohydrolase activity
pantothenate hydrolase activity
pantothenase activity

Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine. [EC:3.5.1.22, RHEA:12448]


palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity

Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate. [EC:3.5.1.11]


Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. [EC:3.5.1.52]


N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity

Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate. [EC:3.5.1.18, RHEA:22608]


Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate. [EC:3.5.1.96, RHEA:15169]


Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. [EC:3.5.1.5, RHEA:20557]


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. [ISBN:0198506732]


Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid. [UM-BBD_reactionID:r0122]


Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-. [UM-BBD_reactionID:r1414]


agmatinase activity
agmatine ureohydrolase activity

Catalysis of the reaction: agmatine + H(2)O = putrescine + urea. [EC:3.5.3.11, RHEA:13929]


allantoicase activity
allantoate amidinohydrolase activity

Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea. [EC:3.5.3.4, RHEA:11016]


Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3. [PMID:1991731]


Catalysis of the reaction: ammeline + H2O = ammelide + NH3. [PMID:1991731]


L-arginine amidinohydrolase activity
arginine amidinase activity
arginase activity
canavanase activity
L-arginase activity

Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. [EC:3.5.3.1]


arginine dihydrolase activity
L-arginine deiminase activity
citrulline iminase activity
L-arginine iminohydrolase activity

Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3. [EC:3.5.3.6]


Catalysis of the reaction: creatine + H(2)O = sarcosine + urea. [EC:3.5.3.3, RHEA:22456]


Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine. [UM-BBD_reactionID:r0121]


Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. [EC:3.5.3.18]


Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. [PMID:27393304]


Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+). [EC:3.5.3.23, RHEA:19533]


Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+). [EC:3.5.1.116, RHEA:19809]


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. [GOC:curators]


Catalysis of the reaction: R-CN + H2O = R-COOH + NH3. [EC:3.5.5.7]

aliphatic nitrile aminohydrolase activity


Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil. [EC:3.5.5.6, RHEA:22100]


benzonitrilase activity
nitrilase activity
nitrile aminohydrolase activity

Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. [EC:3.5.5.1, GOC:kd]


Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+). [EC:3.5.5.8, RHEA:21464]


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds

OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles. [GOC:ai]


Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine. [EC:3.5.4.43]


Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine. [EC:3.5.4.42]


hydrolase activity, acting on carbon-sulphur bonds

hydrolase activity, acting on carbon-sulfur bonds

Catalysis of the hydrolysis of any carbon-sulfur bond, C-S. [GOC:jl]


Catalysis of the reaction: sulfite + UDP-D-glucose = H(2)O + UDP-6-sulfoquinovose. [EC:3.13.1.1, RHEA:13197]


hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond. [GOC:jl]


Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. [GOC:mah, UniProtKB-KW:KW-0063]


carboxylic acid esterase activity
carboxyesterase activity
carboxylic esterase activity
carboxylesterase activity
carboxylate esterase activity
carboxylic ester hydrolase activity
esterase B

Catalysis of the hydrolysis of a carboxylic ester bond. [EC:3.1.1.-, EC:3.1.1.1, GOC:curators]


Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate. [UM-BBD_reactionID:r0167]


Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. [EC:3.1.1.47]


Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate. [UM-BBD_reactionID:r0419]


6-PGL
phosphogluconolactonase activity
6-phosphogluconolactonase activity

Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+). [EC:3.1.1.31, RHEA:12556]


acetylesterase activity
acetic-ester acetylhydrolase activity

Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. [EC:3.1.1.6]


Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan. [PMID:10801485]


Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. [EC:3.1.1.53, PMID:1991039]


Catalysis of the deacetylation of xylans and xylo-oligosaccharides. [EC:3.1.1.72]


aminoacyl-transfer ribonucleate hydrolase activity

N-substituted aminoacyl transfer RNA hydrolase activity

Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. [EC:3.1.1.29]


Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. [EC:3.1.1.2]


Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate. [UM-BBD_reactionID:r0016]


Catalysis of the reaction: acetylcholine + H2O = choline + acetate. [EC:3.1.1.7]


juvenile hormone analog esterase activity

juvenile hormone carboxyesterase activity

Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone. [PMID:11267890, RHEA:16393]


carboxymethylene butenolide hydrolase activity

Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate. [EC:3.1.1.45]


choline esterase II (unspecific) activity

Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. [EC:3.1.1.8]


Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol. [EC:3.1.1.67]


Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide. [EC:3.1.1.73]


Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. [EC:3.1.1.17]


Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group. [PMID:11640988]


Catalysis of the hydrolysis of a lipid or phospholipid. [GOC:mah]


Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. [EC:3.1.1.34, GOC:bf]


Catalysis of the hydrolysis of a glycerophospholipid. [ISBN:0198506732]


Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. [EC:3.1.1.5]


Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. [EC:3.1.1.32]


OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.32]

phosphatidylserine-specific phospholipase A1 activity


phosphatidolipase activity
phospholipase A2 activity
lecithinase A activity

Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801]


OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.4]


calcium-dependent cytosolic phospholipase A2 activity


calcium-independent cytosolic phospholipase A2 activity


calcium-dependent secreted phospholipase A2 activity


Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. [EC:3.1.4.3, GOC:mah]


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol. [EC:4.6.1.13]


phosphoinositide phospholipase C activity

phosphatidylinositol phospholipase C activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). [EC:3.1.4.11, RHEA:33179]


Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. [EC:3.1.4.4]


glycosylphosphatidylinositol phospholipase D activity

phosphatidylinositol-specific phospholipase D activity

phosphatidylinositol-glycan-specific phospholipase D activity

Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. [EC:3.1.4.50]


UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity

UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity

dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity

UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity

UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity

uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity

UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. [EC:2.7.8.15]


pectinoesterase activity
pectinesterase activity
pectin demethoxylase activity
pectin methyl esterase activity
pectin pectylhydrolase activity
pectase activity
pectin methoxylase activity

Catalysis of the reaction: pectin + n H2O = n methanol + pectate. [EC:3.1.1.11]


Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. [EC:3.1.1.61, RESID:AA0072]


cholesterol ester hydrolase activity
sterol ester hydrolase activity
cholesteryl ester synthase activity
steryl-ester acylhydrolase activity
triterpenol esterase activity
cholesteryl ester hydrolase activity
cholesterase activity
acylcholesterol lipase activity
cholesteryl esterase activity

Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. [EC:3.1.1.13]


Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate. [UM-BBD_reactionID:r0583]


diphosphoric monoester hydrolase activity

Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group. [GOC:ai]


Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. [EC:3.1.7.2]


Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+. [MetaCyc:RXN0-1661, PMID:4565531]


Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. [EC:3.1.4.-, GOC:curators]


2',3'-cyclic nucleotide 3'-phosphodiesterase activity

2',3'-cyclic nucleotide 3'-phosphohydrolase activity

2':3'-cyclic nucleotide 3'-phosphodiesterase activity

cyclic 2',3'-nucleotide 3'-phosphodiesterase activity

Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. [EC:3.1.4.37]

2',3'-cyclic AMP phosphodiesterase activity


2',3'-cyclic AMP 2'-phosphohydrolase activity

2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity

cyclic 2',3'-nucleotide 2'-phosphodiesterase activity

2',3 '-cyclic AMP phosphodiesterase activity

Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. [EC:3.1.4.16]

ribonucleoside 2',3'-cyclic phosphate diesterase activity


3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity

3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity

3',5' cyclic-nucleotide phosphodiesterase activity

cyclic 3',5'-mononucleotide phosphodiesterase activity

cyclic nucleotide phosphodiesterase activity

3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity

cyclic 3',5-nucleotide monophosphate phosphodiesterase activity

cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity

nucleoside 3',5'-cyclic phosphate diesterase activity

cyclic 3',5'-nucleotide phosphodiesterase activity

Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. [GOC:mah]


calmodulin-dependent cyclic-nucleotide phosphodiesterase activity


cyclic AMP-specific phosphodiesterase activity

3',5' cAMP-specific phosphodiesterase activity

adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity

Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277]


cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. [GOC:mah]


cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. [GOC:mah]


photoreceptor cyclic-nucleotide phosphodiesterase activity

Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide. [GOC:curators]


glycerophosphoryl diester phosphodiesterase activity

Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. [EC:3.1.4.46]


Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). [EC:3.1.4.12, RHEA:19253]


[acyl-carrier protein] phosphodiesterase activity

Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein. [EC:3.1.4.14]


Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. [GOC:curators, GOC:pg]


Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate. [EC:3.1.3.68]


Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate. [EC:3.1.3.45, RHEA:11500]


Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. [EC:3.1.3.8]


Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate. [EC:3.1.3.26]


orthophosphoric-monoester phosphohydrolase (acid optimum)

acid nucleoside diphosphate phosphatase activity

acid phosphomonoester hydrolase activity

phosphate-monoester phosphohydrolase (acid optimum)

Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. [EC:3.1.3.2]


thiamine phosphate phosphatase activity
thiamin monophosphate phosphatase
thiamin phosphate phosphatase activity

Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate. [PMID:197075]


orthophosphoric-monoester phosphohydrolase (alkaline optimum)

Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [EC:3.1.3.1]

phosphate-monoester phosphohydrolase (alkaline optimum)


Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. [EC:3.1.8.1]

organophosphorus acid anhydrase activity


2,3-diphosphoglyceric acid phosphatase activity

Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate. [EC:3.1.3.80, GOC:mah, PMID:18413611]


Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. [EC:3.1.3.46]


fructose diphosphate phosphatase activity

fructose bisphosphate phosphatase activity

fructose 1,6-diphosphate phosphatase activity

fructose 1,6-bisphosphate 1-phosphatase activity

fructose 1,6-bisphosphate phosphatase activity

Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. [EC:3.1.3.11]


Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate. [EC:3.1.3.10]


glucose 6-phosphate phosphatase activity

Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate. [EC:3.1.3.9, RHEA:16689]


Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate. [EC:3.1.3.21]

glycerol 3-phosphate phosphohydrolase activity


L-histidinol phosphate phosphatase activity

Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate. [EC:3.1.3.15, RHEA:14465]


inositol bisphosphate phosphatase activity

Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. [GOC:hb]


inositol polyphosphate 1-phosphatase activity

Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. [EC:3.1.3.57, GOC:hb]


Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. [EC:3.1.3.66, GOC:hb]


Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. [GOC:mah]


inositol trisphosphate phosphatase activity

Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. [GOC:bf]


Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate. [GOC:ai]


inositol 1,4,5-trisphosphate phosphatase activity

inositol trisphosphate phosphomonoesterase activity

Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56]


Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate. [GOC:ai]


Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. [GOC:ai]


Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. [EC:3.1.3.67]


inositol 1,3-bisphosphate phosphatase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. [EC:3.1.3.64]


Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate. [MetaCyc:NADPPHOSPHAT-RXN]


Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. [RHEA:22140]


3'(2'),5' bisphosphate nucleotidase activity

Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. [EC:3.1.3.7]


3'-ribonucleotidase activity
3'-phosphatase activity
3' nucleotidase activity
3'-nucleotidase activity
3'-mononucleotidase activity

Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. [EC:3.1.3.6]


5'-mononucleotidase activity
5'-nucleotidase activity
AMPase
UMPase
5'-AMPase
AMP phosphohydrolase
5' nucleotidase activity
5'-AMP nucleotidase

Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. [EC:3.1.3.5]


IMP-GMP specific 5'-nucleotidase activity

OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile. [EC:3.1.3.5, GOC:krc]


phosphatic acid phosphohydrolase activity

Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. [EC:3.1.3.4, GOC:pr]


phosphatidylglycerol phosphate phosphatase activity

Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. [PMID:4292860]


phosphoglycollate phosphatase activity
2-phosphoglycolate phosphatase activity
P-glycolate phosphatase activity
phosphoglycolate hydrolase activity
phosphoglycolate phosphatase activity

Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate. [EC:3.1.3.18, RHEA:14369]


Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. [EC:3.1.3.33]


phosphoprotein phosphatase activity
protein phosphatase activity

Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684]


serine/threonine specific protein phosphatase activity

protein serine/threonine phosphatase activity

Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. [GOC:bf]


calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity

Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. [EC:3.1.3.16, GOC:mah]

calcium-dependent protein serine/threonine phosphatase activity


calcium-dependent protein serine/threonine phosphatase regulator activity

Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. [GOC:ai]


RNA polymerase II CTD heptapeptide repeat phosphatase activity

Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate. [PMID:22622228]

RNA polymerase II carboxy-terminal domain phosphatase activity


Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]

myosin phosphatase, intrinsic catalyst activity


myosin phosphatase, intrinsic regulator activity


protein phosphatase type 1 regulator activity


protein phosphatase type 2A, intrinsic regulator activity


protein phosphatase type 4 regulator activity


calcineurin activity
protein phosphatase type 2B activity


pyruvate dehydrogenase (lipoamide) phosphatase activity

phosphopyruvate dehydrogenase phosphatase activity

[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity

pyruvate dehydrogenase (lipoamide)-phosphatase activity

pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity

[pyruvate dehydrogenase (lipoamide)] phosphatase activity

Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. [EC:3.1.3.43]


[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity


tyrosine O-phosphate phosphatase activity

phosphotyrosine histone phosphatase activity

phosphotyrosine protein phosphatase activity

protein phosphotyrosine phosphatase activity

phosphoprotein phosphatase (phosphotyrosine) activity

Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]


non-membrane spanning protein tyrosine phosphatase activity

Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48]


prenylated protein tyrosine phosphatase activity

Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. [EC:3.1.3.48]


transmembrane receptor protein tyrosine phosphatase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]


Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate. [GOC:mah]


Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. [GOC:mah, PMID:12184814, PMID:17208316]


protein tyrosine/threonine phosphatase activity

Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]


transmembrane receptor protein phosphatase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. [GOC:hjd]


Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. [GOC:jl, PMID:8663293]


trehalose 6-phosphate phosphatase activity

Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate. [EC:3.1.3.12]


Catalysis of the hydrolysis of a phosphoric triester. [EC:3.1.8.-, GOC:curators]


sulfuric ester hydrolase activity
sulphuric ester hydrolase activity

Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. [GOC:ai]


Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol. [UM-BBD_reactionID:r0602]


phenolsulfatase activity
arylsulfatase activity
estrogen sulfatase activity
aryl-sulfate sulphohydrolase activity
aryl-sulfate sulfohydrolase activity
arylsulfohydrolase activity
phenylsulfatase activity
aryl-sulphate sulphohydrolase activity
nitrocatechol sulfatase activity
4-methylumbelliferyl sulfatase activity
arylsulphatase activity

Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. [EC:3.1.6.1]


Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate. [EC:3.1.6.8]


glucurono-2-sulfatase activity
glucuronate-2-sulfatase activity
chondro-2-sulfatase activity
glucuronate-2-sulphatase activity

Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. [EC:3.1.6.18]


L-iduronate 2-sulfate sulfatase activity

Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. [EC:3.1.6.13]


N-acetylgalactosamine 4-sulfate sulfohydrolase activity

Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. [EC:3.1.6.12]


2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity

N-acetylglucosamine 6-sulfate sulfatase activity

Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. [EC:3.1.6.14]


3-beta-hydroxysteroid sulfate sulfatase activity

dehydroepiandrosterone sulfate sulfatase activity

Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. [EC:3.1.6.2]


Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. [EC:3.1.2.-]


2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity

2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity

Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite. [EC:3.13.1.3, RHEA:12945]


Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. [GOC:ai]


Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA. [UM-BBD_reactionID:r0193]


3-hydroxy-isobutyryl CoA hydrolase activity

Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. [EC:3.1.2.4]


Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+). [EC:3.1.2.23, RHEA:11948]


Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA. [UM-BBD_reactionID:r0206]


acetyl coenzyme A hydrolase activity
acetyl-CoA acylase activity
acetyl-CoA hydrolase activity
acetyl coenzyme A acylase activity
acetyl-CoA thiol esterase activity
acetyl-CoA deacylase activity

Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). [EC:3.1.2.1, RHEA:20289]


palmitoyl-CoA deacylase activity
palmitoyl coenzyme A hydrolase activity
palmityl-CoA deacylase activity
palmitoyl-CoA hydrolase activity
palmitoyl thioesterase activity

Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. [EC:3.1.2.2]


succinyl coenzyme A hydrolase activity
succinyl-CoA hydrolase activity
succinyl coenzyme A deacylase activity

Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate. [EC:3.1.2.3, RHEA:11516]


Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. [EC:3.1.2.6]


Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. [EC:3.1.2.22]


Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+). [EC:3.1.2.12, RHEA:14961]


myristoyl-[acyl-carrier protein] hydrolase activity

Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate. [EC:3.1.2.14, MetaCyc:RXN-10727]


oleoyl-[acyl-carrier protein] hydrolase activity

Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate. [EC:3.1.2.14]

oleoyl-acyl carrier protein thioesterase activity


palmitoyl-[acyl-carrier protein] hydrolase activity

Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate. [EC:3.1.2.14, MetaCyc:RXN-9549]


Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. [GOC:ai]

triphosphoric monoester hydrolase activity


deoxyguanosine 5-triphosphate triphosphohydrolase activity

deoxyguanosine triphosphate triphosphohydrolase activity

Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate. [EC:3.1.5.1, RHEA:15193]


hydrolase activity, acting on ether bonds

Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. [GOC:ai, GOC:jl]


Catalysis of the hydrolysis of an ether bond, -O-. [EC:3.3.2.-, GOC:ai]


Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4). [EC:3.3.2.6, RHEA:22324]


Catalysis of the reaction: an epoxide + H2O = a glycol. [EC:3.3.2.10]


Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol. [UM-BBD_enzymeID:e0049]


Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers. [UM-BBD_enzymeID:e0051]


Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol. [GOC:mah, PMID:8396141]

juvenile hormone epoxide hydrolase activity


Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. [EC:3.3.2.8]


Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene. [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536]


Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0536]


Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0535]


Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene. [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560]


phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity

Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0560]


phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity

Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0496]


2,3 dihydro-2,3 dihydroxybenzoate synthase activity

Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. [EC:3.3.2.1, RHEA:11112]


trialkylsulfonium hydrolase activity
trialkylsulphonium hydrolase activity

Catalysis of the hydrolysis of a thioether bond, -S-. [EC:3.3.1.-, GOC:ai]


Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. [EC:3.3.1.1]


hydrolase activity, hydrolyzing N-glycosyl compounds

Catalysis of the hydrolysis of any N-glycosyl bond. [GOC:jl]


Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine. [EC:3.2.2.9]


ADP-ribose-L-arginine cleavage enzyme activity

protein ADP-ribosylarginine hydrolase activity

Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. [EC:3.2.2.19]

ADP-ribose-L-arginine cleaving enzyme activity


AMP phosphoribohydrolase activity
adenylate nucleosidase activity
AMP nucleosidase activity

Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine. [EC:3.2.2.4, RHEA:20129]

adenosine monophosphate nucleosidase activity


Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose. [EC:3.2.2.16]


Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]


nicotinamide mononucleotide nucleosidase activity

Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide. [EC:3.2.2.14, RHEA:23140]


purine-specific nucleoside N-ribohydrolase activity

Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose. [EC:3.2.2.1]


Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule. [GOC:mah]


rRNA N-glycosylase activity
RNA N-glycosidase activity
ricin
rRNA N-glycohydrolase activity
rRNA N-glycosidase activity

Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species. [EC:3.2.2.22, GOC:mah]

ribosomal ribonucleate N-glycosidase activity


uridine ribohydrolase activity
uridine nucleosidase activity

Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil. [EC:3.2.2.3, RHEA:15577]


hydrolase activity, hydrolyzing O-glycosyl compounds

Catalysis of the hydrolysis of any O-glycosyl bond. [GOC:mah]


Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate. [EC:3.2.1.139]


Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. [EC:3.2.1.55, GOC:mf]


Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. [EC:3.2.1.40]


Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. [GOC:mah]


Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. [EC:3.2.1.18]


Catalysis of the hydrolysis of amylose or an amylose derivative. [GOC:ai]


Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. [PMID:12527308]


beta-amylase activity
saccharogen amylase activity

Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. [PMID:18390594]


Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. [EC:3.2.1.26, MetaCyc:RXN-9985]


Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. [EC:3.2.1.31]


Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. [EC:3.2.1.4]


Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains. [EC:3.2.1.91]


Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]


Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain. [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]


Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan. [EC:3.2.1.132]


Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. [GOC:ai]


alpha-L-fucosidase activity
alpha-L-fucoside fucohydrolase activity

Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. [EC:3.2.1.51]


Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. [GOC:ai]


Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase. [EC:3.2.1.22]


Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. [EC:3.2.1.23]


Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. [ISBN:0198506732]


Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20]


Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. [EC:3.2.1.21, PMID:12594539]


phosphocellobiase activity
6-phospho-beta-glucosidase activity
phospho-beta-glucosidase activity

Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose. [EC:3.2.1.86]


Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. [EC:3.2.1.3]


Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans. [EC:3.2.1.75]


Glc3Man9GlcNAc2 oligosaccharide glucosidase activity

mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity

Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). [EC:3.2.1.106]


Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. [EC:3.2.1.10]


sucrose alpha-D-glucohydrolase activity
sucrase-isomaltase activity
sucrose alpha-glucosidase activity
sucrose-alpha-D-glucohydrolase activity

Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. [EC:3.2.1.48, MetaCyc:RXN-1461]


Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid. [PMID:10441389, PMID:12044176]


Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. [PMID:10916150]


Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. [ISBN:0721662544]


Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. [EC:3.2.1.49]


Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. [EC:3.2.1.50]


Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]


Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. [EC:3.2.1.52]


hyalurononglucosaminidase activity
hyaluronate 4-glycanohydrolase activity
chondroitinase I activity
hyaluronoglucosaminidase activity

Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. [EC:3.2.1.35]


2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity

Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. [EC:3.1.4.45]


Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. [EC:3.2.1.76]


Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. [PMID:12023280]


Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. [GOC:ai]


Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. [EC:3.2.1.24]


Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. [EC:3.2.1.130]


Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. [EC:3.2.1.101]


Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. [EC:3.2.1.25]


Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans. [EC:3.2.1.78]


Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+. [MetaCyc:GDPMANMANHYDRO-RXN]


Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. [EC:3.2.1.-, GOC:ai]


Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. [GOC:bf, PMID:25092655]


GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity

Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). [EC:3.2.1.114]


Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans. [EC:3.2.1.15]


S-ribosylhomocysteine lyase activity
LuxS
ribosylhomocysteinase activity

Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. [RHEA:17753]


myrosinase activity
sinigrinase activity
thioglucosidase activity
thioglucoside glucohydrolase activity

Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar. [EC:3.2.1.147]


Catalysis of the hydrolysis of trehalose or a trehalose derivative. [GOC:ai, PMID:31925485]


Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate. [EC:3.2.1.93]


Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. [PMID:19897915, RHEA:32675]


1,4-beta-D-xylan xylohydrolase activity
xylobiase activity
beta-xylosidase activity
exo-1,4-beta-xylosidase activity
beta-D-xylopyranosidase activity
exo-1,4-xylosidase activity
exo-1,4-beta-D-xylosidase activity

Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini. [EC:3.2.1.37]


peptide hydrolase activity
proteinase
protease activity
peptidase activity
hydrolase, acting on peptide bonds

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]


Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]


Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide. [EC:3.4.11.4]


Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. [ISBN:0198506732]


aspartic endopeptidase activity, intramembrane cleaving

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. [GOC:jl, ISBN:0198506732]


Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. [GOC:mah]


cysteine-type peptidase activity
thiol protease activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]


Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue. [PMID:10872455]


OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]


ubiquitin-like specific protease activity

ubiquitin-like protein peptidase activity

ubiquitin-like protein-specific protease activity

small conjugating protein-specific isopeptidase activity

small conjugating protein-specific protease activity

ubiquitin-like protein-specific isopeptidase activity

An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins. [PMID:19489724]


A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated. [GOC:mah, PMID:30213559]


An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [GOC:mah, PMID:25628956]


SUMO-specific protease activity
SUSP
deSUMOylase activity
ULP

An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated. [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258]


thiol-dependent ubiquitinyl hydrolase activity

thiol-dependent ubiquitin-specific protease activity

An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]


Catalysis of the hydrolysis of a dipeptide. [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]


Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]


Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


metalloendoprotease activity
metalloendopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. [https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]


Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]


Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]


Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]


zinc D-Ala-D-Ala carboxypeptidase activity

Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine. [EC:3.4.17.14]


metalloproteinase activity
metalloprotease activity

Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes. [EC:3.4.19.-, PMID:20157488, PMID:9920379]


beta-aspartyl peptidase activity
beta-aspartyl dipeptidase activity

Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide. [EC:3.4.19.5]


Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. [GOC:mah, PMID:9920379]


Catalysis of the release of C-terminal dipeptides from a polypeptide chain. [GOC:mb]


Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]


serine-type D-Ala-D-Ala carboxypeptidase activity

Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. [EC:3.4.16.4]


Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


Catalysis of the release of an N-terminal tripeptide from a polypeptide. [GOC:mah]


Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity. [EC:3.4.25.1]


Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase]


imidazole glycerol phosphate synthase activity

imidazoleglycerol phosphate synthase activity

Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+). [RHEA:24793]


Catalysis of the integration of one DNA segment into another. [GOC:mah]


integrase activity involved in establishment of integrated proviral latency

Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. [GOC:jl]


Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [ISBN:0198506732]


Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. [GOC:mah, ISBN:0198506732]


Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids. [PMID:11884677]


peptidylprolyl cis-trans isomerase activity

peptidyl-prolyl cis-trans isomerase activity

Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]


cyclophilin-type peptidyl-prolyl cis-trans isomerase activity

OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0). [EC:5.2.1.8]


Catalysis of the reaction: all-trans-retinal = 11-cis-retinal. [PMID:21447403]


Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. [EC:5.3.-.-, GOC:curators]


intramolecular isomerase activity, interconverting aldoses and ketoses

intramolecular oxidoreductase activity, interconverting aldoses and ketoses

Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. [GOC:jl]


phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity

N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity

Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. [EC:5.3.1.16, RHEA:15469]


Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. [EC:5.3.1.17, RHEA:23896]

4-deoxy-L-threo-5-hexulose uronate isomerase activity


methylthioribose 1-phosphate isomerase activity

Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. [EC:5.3.1.23, RHEA:19989]


Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate. [MetaCyc:RXN0-303]


Catalysis of the reaction: D-arabinose = D-ribulose. [EC:5.3.1.3]


Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+). [EC:5.3.1.13, RHEA:23104]


Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al. [EC:5.3.1.21, RHEA:17861]


glucosamine phosphate deaminase activity

2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)

Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+). [EC:3.5.99.6, RHEA:12172]


Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. [EC:5.3.1.9]


Catalysis of the reaction: D-glucuronate = D-fructuronate. [EC:5.3.1.12]


Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. [EC:5.3.1.22, RHEA:11952]


Catalysis of the reaction: L-arabinose = L-ribulose. [EC:5.3.1.4, RHEA:14821]


L-fucose ketol-isomerase activity
L-fucose isomerase activity

Catalysis of the reaction: L-fucose = L-fuculose. [EC:5.3.1.25]


Catalysis of the reaction: L-rhamnose = L-rhamnulose. [EC:5.3.1.14, RHEA:23160]


Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. [EC:5.3.1.8]


Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. [EC:5.3.1.24, RHEA:21540]


Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. [EC:5.3.1.6, RHEA:14657]


Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. [EC:5.3.1.1, RHEA:18585]


Catalysis of the reaction: D-xylose = D-xylulose. [EC:5.3.1.5]


intramolecular isomerase activity, interconverting keto- and enol-groups

intramolecular oxidoreductase activity, interconverting keto- and enol-groups

Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. [GOC:jl]


intramolecular oxidoreductase activity, other intramolecular oxidoreductases

OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized. [GOC:ai]


Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate. [RHEA:27401]


Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde. [UM-BBD_reactionID:r0019]


Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate. [EC:5.3.99.6, RHEA:22592]


Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively. [PMID:8837512]


Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene). [PMID:8837512]


prostaglandin-R-prostaglandin D isomerase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). [EC:5.3.99.2, RHEA:10600]


Catalysis of the reaction: styrene oxide = phenylacetaldehyde. [EC:5.3.99.7, RHEA:21604]


intramolecular isomerase activity, transposing C=C bonds

intramolecular oxidoreductase activity, transposing C=C bonds

Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. [EC:5.3.3.-, GOC:mah]


5-carboxymethyl-2-hydroxymuconic acid isomerase activity

Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. [EC:5.3.3.10]


Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. [MetaCyc:RXN3O-203, PMID:8988026]

delta-8-delta-7 sterol isomerase activity


delta3-delta2 enoyl-CoA isomerase activity

Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA. [RHEA:45900]


L-dopachrome keto-enol isomerase activity

Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. [EC:5.3.3.12, RHEA:13041]

L-dopachrome-methyl ester tautomerase activity


Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. [RHEA:23284]


Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate. [RHEA:12348]


delta5(or delta4)-3-keto steroid isomerase activity

delta5-3-keto steroid isomerase activity

Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. [EC:5.3.3.1]

delta(5)-3-keto steroid isomerase activity


intramolecular isomerase activity, transposing S-S bonds

intramolecular oxidoreductase activity, transposing S-S bonds

Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. [EC:5.3.4.-, GOC:mah]


protein disulfide-isomerase
protein disulphide isomerase activity
protein thiol-disulfide exchange
protein thiol-disulphide exchange
disulphide bond formation
protein disulfide isomerase activity
protein disulfide-isomerase reaction

Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]


The catalysis of certain rearrangements of a molecule to break or form a ring. [GOC:jl]


Catalysis of the reaction: alpha-pinene = limonene. [UM-BBD_reactionID:r0712]


alpha-pinene-oxide decyclase activity
alpha-pinene-oxide lyase (decyclizing)

Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal. [EC:5.5.1.10, RHEA:16693]


chalcone--flavonone isomerase activity
chalcone isomerase activity
chalcone-flavanone isomerase activity

Catalysis of the reaction: a chalcone = a flavanone. [EC:5.5.1.6]


Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. [EC:5.5.1.7]


Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate. [EC:5.5.1.11]


ent-copalyl diphosphate synthase activity

Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate. [EC:5.5.1.13, RHEA:14841]


D-glucose 6-phosphate cycloaldolase activity

inositol 1-phosphate synthetase activity

inositol 1-phosphate synthatase activity

glucose-6-phosphate inositol monophosphate cycloaldolase activity

Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. [EC:5.5.1.4, RHEA:10716]


Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate. [RHEA:30031]


Catalysis of the reaction: pinocarveol = carveol. [UM-BBD_reactionID:r0715]


Catalysis of the transfer of a functional group from one position to another within a single molecule. [GOC:mah]


intramolecular transferase activity, phosphotransferases

phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers

Catalysis of the transfer of a phosphate group from one position to another within a single molecule. [GOC:mah]


Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate. [EC:5.4.2.6, RHEA:20113]


Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. [EC:5.4.2.4]


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. [EC:5.4.2.3, RHEA:23804]


Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. [EC:5.4.2.2]


Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. [EC:5.4.2.10, RHEA:23424]


Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. [EC:5.4.2.1]


glycerate phosphomutase (diphosphoglycerate cofactor) activity

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate. [EC:5.4.2.1]


2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity

Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate. [EC:5.4.2.1]


Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. [EC:5.4.2.8, RHEA:11140]


Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. [EC:5.4.2.7]


intramolecular transferase activity, transferring acyl groups

Catalysis of the transfer of an acyl group from one position to another within a single molecule. [GOC:mah]


Catalysis of the reaction: precorrin-8X = hydrogenobyrinate. [EC:5.4.99.61]


intramolecular transferase activity, transferring amino groups

Catalysis of the transfer of an amino group from one position to another within a single molecule. [GOC:mah]


Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. [EC:5.4.3.8, RHEA:14265]


intramolecular transferase activity, transferring other groups

OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized. [GOC:ai]


Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin. [GOC:jl, MetaCyc:RXN-8434, PMID:10848960]


Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin. [PMID:9746369]


Catalysis of the reaction: chorismate = prephenate. [EC:5.4.99.5, RHEA:13897]


(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)

Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol. [EC:5.4.99.8, RHEA:21308]


isochorismate mutase activity
isochorismate synthetase activity
isochorismate hydroxymutase activity

Catalysis of the reaction: chorismate = isochorismate. [EC:5.4.4.2, RHEA:18985]


lanosterol 2,3-oxidosqualene cyclase activity

squalene 2,3-epoxide:lanosterol cyclase activity

(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)

2,3-epoxysqualene lanosterol cyclase activity

Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. [EC:5.4.99.7, RHEA:14621]


Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol. [MetaCyc:RXN-111, PMID:9883589]


methylmalonyl coenzyme A mutase activity

methylmalonyl-CoA CoA-carbonyl mutase activity

methylmalonyl coenzyme A carbonylmutase activity

Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. [EC:5.4.99.2, RHEA:22888]


Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose. [EC:5.4.99.9]


OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized. [GOC:ai]


Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. [GOC:mah, PMID:8811192]


DNA topoisomerase (ATP-hydrolysing)
DNA topoisomerase type II activity

Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. [PMID:8811192]

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity


type I topoisomerase activity
type I DNA topoisomerase activity
DNA topoisomerase I activity

Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. [PMID:8811192]

DNA topoisomerase type I (single strand cut, ATP-independent) activity


Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969]

D-sedoheptulose 7-phosphate isomerase activity


Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. [GOC:mah, ISBN:0198506732]


racemase and epimerase activity, acting on amino acids and derivatives

Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. [GOC:mah]


Catalysis of the reaction: L-alanine = D-alanine. [EC:5.1.1.1, RHEA:20249]


Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. [EC:5.1.1.7, RHEA:15393]


Catalysis of the reaction: L-glutamate = D-glutamate. [EC:5.1.1.3, RHEA:12813]


isopenicillin-N epimerase activity
isopenicillin N epimerase activity

Catalysis of the reaction: isopenicillin N = penicillin N. [EC:5.1.1.17, RHEA:20033]


Catalysis of the reaction: L-lysine = D-lysine. [EC:5.1.1.5]


Catalysis of the reaction: L-methionine = D-methionine. [EC:5.1.1.2, RHEA:12492]


Catalysis of the reaction: L-proline = D-proline. [EC:5.1.1.4, RHEA:10680]


Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine. [EC:5.1.1.16]


Catalysis of the synthesis of free D-serine from L-serine. [GOC:kd]


Catalysis of the reaction: L-threonine = D-threonine. [EC:5.1.1.6, RHEA:13913]


racemase and epimerase activity, acting on carbohydrates and derivatives

Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. [GOC:mah]


Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. [EC:5.1.3.20, RHEA:17577]


Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. [EC:5.1.3.3]


Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose. [EC:5.1.3.13, RHEA:16969]


Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. [EC:5.1.3.4, RHEA:22368]

L-ribulose 5-phosphate 4-epimerase activity


D-ribulose 5-phosphate epimerase activity

ribulose 5-phosphate 3-epimerase activity

Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. [EC:5.1.3.1, RHEA:13677]


uridine diphosphoglucose epimerase activity

uridine diphosphate galactose 4-epimerase activity

uridine diphosphate glucose 4-epimerase activity

uridine diphosphoglucose 4-epimerase activity

Catalysis of the reaction: UDP-glucose = UDP-galactose. [EC:5.1.3.2]


uridine diphosphoacetylglucosamine 2'-epimerase activity

uridine diphospho-N-acetylglucosamine 2'-epimerase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. [EC:5.1.3.14]


UDP acetylglucosamine epimerase activity

uridine diphosphoacetylglucosamine epimerase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. [EC:5.1.3.7]

uridine diphosphate N-acetylglucosamine-4-epimerase activity


racemase and epimerase activity, acting on hydroxy acids and derivatives

Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule. [GOC:mah]


Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate. [UM-BBD_reactionID:r0502]


3-hydroxybutyryl coenzyme A epimerase activity

Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. [EC:5.1.2.3]


Catalysis of the reaction: D-carnitine = L-carnitine. [MetaCyc:CARNRACE-RXN]


Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. [UM-BBD_reactionID:r0163]


Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. [EC:5.2.1.2]


Catalysis of the reaction: (S)-mandelate = (R)-mandelate. [EC:5.1.2.2]


racemase and epimerase activity, acting on other compounds

OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives. [GOC:ai]


Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA. [EC:5.1.99.4]


methylmalonyl coenzyme A racemase activity

Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA. [EC:5.1.99.1, RHEA:20553]


Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]


Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). [EC:2.7.1.127, RHEA:11020]

inositol trisphosphate 3-kinase activity


Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+). [EC:2.7.6.3, RHEA:11412]


acetate kinase (phosphorylating) activity

Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate. [EC:2.7.2.1]


Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. [EC:2.7.2.8]


5'-phosphoadenosine sulfate kinase activity

adenosine phosphosulfate kinase activity

adenosine 5'-phosphosulfate kinase activity

Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. [EC:2.7.1.25]


Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate. [GOC:jl]


adenosine 5'-triphosphate-arginine phosphotransferase activity

Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+). [EC:2.7.3.3, RHEA:22940]


Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+). [GOC:mah]


Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+). [EC:2.7.2.4, RHEA:23776]


Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+). [EC:2.7.2.11, RHEA:14877]


Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). [EC:2.7.1.39, RHEA:13985]


Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate. [EC:2.7.2.2]


Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. [GOC:jl]


Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+). [EC:2.7.1.58, RHEA:16525]


2-keto-3-deoxy-D-gluconic acid kinase activity

Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+). [EC:2.7.1.45, RHEA:14797]


Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate. [EC:2.7.1.55]


D-ribulokinase (phosphorylating)
D-ribulokinase activity

Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate. [EC:2.7.1.47]


Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. [EC:2.7.1.4]


Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.6, RHEA:13553]


Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. [EC:2.7.1.2]


hexokinase type IV (glucokinase) activity

Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. [EC:2.7.1.1]


Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. [EC:2.7.1.3]


L-arabinokinase (phosphorylating)
L-arabinokinase activity

Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.46, RHEA:20153]


Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.51, RHEA:12376]


ATP:L(or D)-ribulose 5-phosphotransferase activity

Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. [EC:2.7.1.16]


Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+). [EC:2.7.1.59, RHEA:17417]


Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. [EC:2.7.1.60]


Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. [GOC:jl]


Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate. [EC:2.7.1.56]


Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). [EC:2.7.1.105, RHEA:15653]


nucleotide triphosphate-dependent phosphofructokinase activity

Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. [EC:2.7.1.11]


Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate. [EC:2.7.1.5]


phosphoribosyl diphosphate synthetase activity

ribose phosphate diphosphokinase activity

phosphoribosyl pyrophosphate synthetase activity

Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15609]


Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+). [EC:2.7.1.17, RHEA:10964]


Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate. [EC:2.7.1.53]


choline phosphokinase activity
choline-ethanolamine kinase activity
choline kinase activity
choline kinase (phosphorylating)

Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+). [EC:2.7.1.32, RHEA:12837]


Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate. [http://www.mblab.gla.ac.uk/, PMID:1655696]


adenosine triphosphate-creatine transphosphorylase activity

Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). [EC:2.7.3.2, RHEA:17157]


Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. [MetaCyc:RXN3DJ-11417]


dephosphocoenzyme A kinase (phosphorylating)

Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+). [EC:2.7.1.24, RHEA:18245]


arachidonoyl-specific diacylglycerol kinase activity

Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. [EC:2.7.1.107, GOC:elh]


diphosphate:purine nucleoside phosphotransferase activity

diphosphate-dependent nucleoside kinase activity

diphosphate-purine nucleoside kinase activity

pyrophosphate-purine nucleoside kinase activity

Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide. [EC:2.7.1.143]

pyrophosphate-dependent nucleoside kinase activity


dolichol phosphokinase activity
dolichol kinase activity

Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. [EC:2.7.1.108]


ethanolamine kinase activity
ethanolamine kinase (phosphorylating)
ethanolamine phosphokinase activity

Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine. [EC:2.7.1.82, RHEA:13069]


Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+). [EC:2.7.1.31, RHEA:23516]


Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+). [EC:2.7.1.30, RHEA:21644]


Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+). [EC:2.7.1.29, RHEA:15773]


histidine phosphotransfer kinase activity

Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. [PMID:11842140]


Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+). [EC:2.7.1.50, RHEA:24212]


Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+). [EC:2.7.1.49, RHEA:23096]


Catalysis of the reaction: ATP + inosine = ADP + IMP. [EC:2.7.1.73]


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). [EC:2.7.1.67, RHEA:19877]


Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate. [EC:2.7.1.64]