aspartyl protease activity involved in APP catabolism

aspartyl protease activity involved in amyloid precursor protein catabolism

aspartyl protease activity involved in amyloid precursor protein catabolic process

aspartyl protease activity involved in APP catabolic process


aspartyl protease activity involved in amyloid precursor protein degradation


aspartyl protease activity involved in amyloid precursor protein breakdown


aspartic protease activity involved in APP catabolism

aspartic protease activity involved in amyloid precursor protein catabolic process

aspartic protease activity involved in amyloid precursor protein catabolism

aspartic protease activity involved in APP catabolic process


aspartic protease activity involved in amyloid precursor protein degradation


aspartic protease activity involved in amyloid precursor protein breakdown


aspartate protease activity involved in amyloid precursor protein catabolism

aspartate protease activity involved in APP catabolism

aspartate protease activity involved in amyloid precursor protein catabolic process

aspartate protease activity involved in APP catabolic process


aspartate protease activity involved in amyloid precursor protein degradation


aspartate protease activity involved in amyloid precursor protein breakdown


up-regulation of serine protease activity

upregulation of serine protease activity

up regulation of serine protease activity


positive regulation of serine protease activity


negative regulation of serine protease activity


down-regulation of serine protease activity

downregulation of serine protease activity

down regulation of serine protease activity


regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering


nuclear rRNA polyadenylation involved in poly(A)-dependent rRNA catabolic process


nuclear rRNA polyadenylation during polyadenylation-dependent rRNA catabolic process


TERRA RNA transcription from RNA pol II promoter


response to the introduction of novel objects


A type of regulated cell death initiated by hyperactivation of POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1) as a consequence of DNA DAMAGE; OXIDATIVE STRESS; HYPOXIA; HYPOGLYCEMIA; or INFLAMMATION. This leads to DNA FRAGMENTATION and CHROMATIN condensation.


stress-activated AMP-activated protein kinase signaling cascade


chaperone-mediated autophagy receptor complex location


nucleoside diphosphate reductase activity


class III ribonucleotide reductase activity


class II ribonucleotide reductase activity


class II ribonucleoside-diphosphate reductase activity


class I ribonucleotide reductase activity


anaerobic iron-sulfur-dependent ribonucleotide reductase activity


aerobic non-heme iron-dependent ribonucleotide reductase activity


adenosylcobalamin-dependent ribonucleotide reductase activity


CoQH2-cytochrome c reductase complex location


OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites. [PMID:11264310, PMID:24312009]


upregulation of metalloenzyme activity
up-regulation of metalloenzyme activity


midbrain dopaminergic neuron-astrocyte crosstalk


mesencephalic dopaminergic neuron-astrocyte crosstalk


glycoprotein mannose trimming on A branch


conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2


conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2


conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2


conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2


endoplasmic reticulum-associated protein degradation pathway


eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response


EIF2AK3-mediated unfolded protein response


inositol-requiring enzyme 1-mediated unfolded protein response


response to hydroxymethylglutaryl-CoA reductase inhibitor


SNF1/AMPK protein kinase complex location


ADP-activated protein kinase complex location


glucose catabolic process to mixed acids


D-lactate biosynthetic process from methylglyoxal

D-lactate biosynthesis from methylglyoxal


multicellular organism reproductive behavior


prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity


proline, 2-oxoglutarate dioxygenase activity


mannose-9 processing alpha-mannosidase activity


OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension. [PMID:24055447]


OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension. [PMID:24055447]


proteasome localization to nuclear periphery

Any process in which the proteasome is transported to, or maintained at the nuclear periphery. [PMID:11084332]


ligand-gated ion channel signalling pathway

ligand-gated ion channel signaling pathway

The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription. [GOC:bhm, PMID:25869137]


A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs. [PMID:26669262]


A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]


A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19854130, PMID:22965356]


FNIP-Folliculin RagC/D GAP complex location

A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2. [GOC:rn, PMID:24095279, PMID:26387955, PMID:34805795]


A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p. [GOC:rb, PMID:9660861]


nuclear membrane complex Bqt3-Bqt4 location

A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4. [PMID:19948484]


Ubp3-Bre5 deubiquitination complex location

Ubp3-Bre5 ubiquitin protease complex location

A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p. [GOC:rb, PMID:12778054, PMID:18391941]


A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin. [GOC:rb, PMID:8108735]


Wnt-FZD-LRP5/6 trimeric complex location

A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6. [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360]


Haemonchus galactose-containing glycoprotein complex location

A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus. [PMID:11166393]


nucleoplasmic periphery of the nuclear pore complex location

Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex. [PMID:10633080]


Msd1-Wdr8-Pkl1 complex location
Msd1-Wdr8-Pkl1 complex
MWP complex location

A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin. [PMID:25987607, PMID:29021344]


A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins. [GOC:bhm, PMID:24311597]


A quatrefoil tethering complex required for endocytic recycling. [PMID:25799061]


A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils. [GOC:ame, PMID:16407954]


p97-p47 complex
VCP-NSFL1C complex location
p97-p47 complex location

A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97. [GOC:bf, GOC:PARL, PMID:9214505]


mitotic spindle assembly checkpoint MAD1-MAD2 complex location

A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. [GOC:bhm, PMID:12006501, PMID:22898774]


tubulin folding cofactor complex location

A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur. [GOC:vw, PMID:12445400]


A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway. [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]


A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes. [GOC:bhm, PMID:15476813, PMID:18777589, PMID:8262940]


cytoplasmic periphery of the nuclear pore complex location

Cytoplasm situated in close proximity to a nuclear pore complex. [PMID:9398662]


death-associated protein kinase 1 - calmodulin complex location

A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding. [GOC:bhm, PMID:20103772]


A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer. [GOC:bhm, PMID:24606918]


HEPS complex
heparanase complex location
HEPS complex location

A protein complex which is capable of heparanase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12927802]


A protein complex which is capable of ATPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181]


trimethylamine-N-oxide reductase (cytochrome c) complex location

A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11056172]


serotonin-activated cation-selective channel complex location

5-hydroxytryptamine receptor 3 complex location

A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]


An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1. [GO_REF:0000088, GOC:bhm, GOC:rb, GOC:TermGenie, PMID:26195633]


dehydrodolichyl diphosphate synthase complex location

A protein complex which is capable of dehydrodolichyl diphosphate synthase activity. [GO_REF:0000088, GOC:TermGenie, PMID:25066056]


carbon phosphorus lyase complex location

A protein complex which is capable of carbon phosphorus lyase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17993513, PMID:21705661, PMID:22089136, PMID:23830682]


phosphatidylinositol phosphate phosphatase complex location

A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12525165]


K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex location

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex location

A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart. [PMID:20829353]


A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes. [PMID:20200227]


chloroplast thylakoid membrane protein complex location

A protein complex that is part of a chloroplast thylakoid membrane. [GOC:dos]


Any protein complex that is part of a respiratory chain. [GOC:dos]


plasma membrane signaling receptor complex location

Any protein complex that is part of the plasma membrane and which functions as a signaling receptor. [GOC:dos]


inner mitochondrial membrane protein complex location

Any protein complex that is part of the inner mitochondrial membrane. [GOC:dos]


outer mitochondrial membrane protein complex location

Any protein complex that is part of the outer mitochondrial membrane. [GOC:dos]


plasma membrane protein complex location

Any protein complex that is part of the plasma membrane. [GOC:dos]


Any protein complex that is part of a membrane. [GOC:dos]


A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. [GOC:pf, PMID:7693675, PMID:8662961]


box H/ACA telomerase RNP complex location

A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283]


A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T. [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067, Wikipedia:P-TEFb]


chaperone-mediated autophagy translocation complex location

A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy. [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626]


pyroptosome complex location
ASC pyroptosome

A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis. [GOC:dph, PMID:17599095]


A cytosolic protein complex that is capable of activating caspase-1. [GOC:dph, PMID:17599095]


SEACAT complex location
GATOR2 complex location
SEACAT complex

A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]


A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function. [GOC:dph, PMID:11420129]


transferase complex location, transferring phosphorus-containing groups

transferase complex, transferring phosphorus-containing groups

A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). [GOC:bhm, GOC:dph]


alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex location

A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity. [GOC:dph, PMID:22089136]


Derlin-1 retro-translocation complex location

ERAD protein dislocation complex location

Derlin-1 retrotranslocation complex location

Derlin-1 protein dislocation complex location

A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]


Derlin-1/VIMP complex
Derlin-1-VIMP complex location
Derlin-1/VIMP complex location

A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome. [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]


UFD1L-NPLOC4 complex
Ufd1-Npl4 binary complex
Ufd1-Npl4 binary complex location
Ufd1-Npl4 cofactor complex
Ufd1/Npl4 complex
Ufd1-Npl4 cofactor complex location
Npl4p-Ufd1p complex location
UFD1-NPL4 complex location
Npl4p-Ufd1p complex
Ufd1/Npl4 complex location
UFD1L-NPLOC4 complex location

A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p. [GOC:bf, GOC:PARL, PMID:10811609, PMID:17289586]


VCP-NPL4-UFD1 AAA ATPase complex location

A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). [PMID:11813000, PMID:16179952]


nucleotide-activated protein kinase complex location

A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). [GOC:bhm, GOC:mah, GOC:vw]


cyclin/CDK positive transcription elongation factor complex location

A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]


Wnt signalosome complex location
LRP5/6 signalosome
Wnt-LRP5/6 signalosome
Wnt signalosome complex

A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]


cytoplasmic side of nuclear pore complex location

The side of the nuclear pore complex (NPC) that faces the cytoplasm. [PMID:8422679]


nucleoplasmic side of nuclear pore complex location

The side of the nuclear pore complex (NPC) that faces the nucleoplasm. [PMID:8422679]


myo-inositol import across plasma membrane

The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:9560432]


RNA N6-methyladenosine dioxygenase activity


protein localisation to microtubule plus-end

protein localization to microtubule plus-end

A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end. [GO_REF:0000087, GOC:TermGenie, PMID:24039245]


A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments. [GOC:dos, PMID:25598228]


endothelial cell chemotaxis to vascular endothelial growth factor

The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF). [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851]


up-regulation of membrane depolarization

up regulation of membrane depolarization

positive regulation of membrane depolarization

Any process that activates or increases the frequency, rate or extent of membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]


meiosis II metaphase/anaphase transition

metaphase/anaphase transition of meiosis II

The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II. [ISBN:0815316194]


metaphase/anaphase transition of meiosis I

The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I. [ISBN:0815316194]


Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. [GOC:dph, GOC:vw, PMID:21389117]


Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half. [PMID:21389117]


The cell cycle process in which a cell progresses from meiosis I to meiosis II. [PMID:21389117]


RTS1 element binding
RTS1 barrier binding

mating type region replication fork barrier binding

Binding to the replication fork barrier found in the mating type region of fission yeast. [PMID:18723894]


microtubule sliding involved in kinetochore retrieval

microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body

microtubule sliding involved in sister kinetochore recapture

A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate. [PMID:18256284]


Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation. [PMID:18256284]


aspartyl autophosphorylation
peptidyl-aspartate autophosphorylation

The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein. [GOC:bf, GOC:PARL, PMID:26134396]


The addition of one or more acetyl groups to a xylan molecule. [PMID:26745802]


vascular smooth muscle cell dedifferentiation

vascular associated smooth muscle cell dedifferentiation

The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079]


Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA. [PMID:11118435]


A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles. [PMID:26226217, PMID:9021878]


microtubule cytoskeleton attachment to nuclear envelope

A process in which the microtubule cytoskeleton is attached to the nuclear envelope. [PMID:14655046, PMID:20507227]


Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA. [PMID:11716358, PMID:15527424]


RNA N1-methyladenosine dioxygenase activity


Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose. [GOC:imk, PMID:26878550]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. [PMID:7765311]


calcium ion regulated lysosome exocytosis

The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. [PMID:10725327, PMID:11511344]


hepatic perisinusoidal cell proliferation

The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver. [GOC:sl, PMID:15358192, PMID:18466260]


nuclear membrane proteasome tether activity

nuclear membrane-proteasome tether activity

nuclear membrane-proteasome anchor activity

proteasome-nuclear membrane anchor activity

The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome. [PMID:16096059]


double-strand break repair involved in meiotic recombination

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. [GOC:mah, PMID:15238514]


The outermost layers of the spore wall, as described in Schizosaccharomyces pombe. [PMID:24623719]


structural constituent of ascospore wall

The action of a molecule that contributes to the structural integrity of an ascospore wall. [PMID:24623719]


integral component of periplasmic side of plasma membrane

The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane. [GOC:bhm, PMID:15919996]


The plasma membrane that is part of the head section of a sperm cell. [PMID:24478030]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism. [PMID:22922217, PMID:26458179]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level). [PMID:24590457]


A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors. [GOC:dph, PMID:25125189]


A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy). [GOC:at, PMID:1480107, Wikipedia:Dinoflagellate]


The cell pole proximal to the most recent cell division. [GOC:jh2, PMID:10231492, PMID:8226658]


The cell pole distal from the most recent cell division. [GOC:jh2, PMID:10231492, PMID:8226658]


A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma. [GOC:giardia, PMID:18462016, PMID:19806154]


meiotic DNA double-strand break resectioning

The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends. [PMID:26130711]


meiotic DNA double-strand break clipping

The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP). [PMID:26130711]


protein localization to cell cortex of cell tip

A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip. [PMID:26150232]


regulation of protein localization to cell cortex of cell tip

Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip. [GOC:vw, PMID:26150232]


mitotic chromosome condensation at kinetochore

mitotic chromosome centromere condensation

The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis. [PMID:21633354]


The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells. [PMID:21633354]


The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis. [PMID:21633354]


Binding to a netrin receptor. [GOC:kmv, PMID:8861902, PMID:9126742]


Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation. [PMID:22150589]


Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+. [PMID:10419476]


Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+. [PMID:10419476]


3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity

Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+. [PMID:10419476, PMID:9628017, RHEA:44452]


The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule. [PMID:25402480]


rRNA cytidine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA. [PMID:25402480]


The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [PMID:25402480]


Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration. [PMID:10369673]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. [PMID:10348814]


vascular smooth muscle cell proliferation

vascular associated smooth muscle cell proliferation

The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [PMID:23246467]


intrinsic component of plasma membrane of cell tip

The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip. [PMID:20624220]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. [PMID:11113082]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. [PMID:11113082]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. [PMID:10348814]


response to growth hormone-releasing factor

response to growth hormone-releasing hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins. [PMID:7720628]


acinous cell proliferation
acinic cell proliferation

The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). [PMID:9788538]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). [PMID:16365184]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. [PMID:25996210, PMID:26306444]


methionyl-initiator methionine tRNA binding

Binding to methionine-initator methionine tRNA. [GOC:hjd, ISBN:9781555810733]


The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles. [PMID:26283797]


The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone. [DOI:10.1038/35052000, PMID:15226425]


protein transport along microtubule to spindle pole body

The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins. [PMID:25987607]


maintenance of vacuole localization
maintenance of vacuolar location
maintenance of vacuolar localization
maintenance of vacuole location

Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. [PMID:26283797]


ribonucleoside-diphosphate reductase inhibitor activity

Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase. [PMID:16317005]


The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. [PMID:17260010, PMID:20363363]


Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. [PMID:25996210, PMID:26306444]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). [PMID:16365184]


poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends

Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P). [PMID:23022480]


sequence-specific double-stranded DNA binding

Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]


A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome. [PMID:9395337]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. [PMID:11268007]


Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP. [PMID:6146630, PMID:8363588]


cellular response to pregnancy specific glycoprotein

cellular response to carcinoembryonic antigen

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins. [PMID:10202129, PMID:14597422]


cellular response to cholinergic differentiation factor

cellular response to leukemia inhibitory factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]


Binding to C-rich, single-stranded DNA. [PMID:8127654]


The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. [PMID:20102719]


Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3). [PMID:9792439]


Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. [PMID:11886857]


response to cholinergic differentiation factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]


basic amino acid transmembrane transport

The directed movement of basic amino acids from one side of a membrane to the other. [GOC:dph, GOC:vw]


response to signal involved in mitotic DNA integrity checkpoint

response to mitotic DNA integrity checkpoint signaling

A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling. [PMID:7548844]


A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location. [PMID:25825517]


L-arginine transmembrane export from vacuole

The directed movement of L-arginine out of the vacuole, across the vacuolar membrane. [PMID:26083598]


Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group. [GOC:vw]


vacuole-mitochondrion membrane contact site

A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles. [PMID:25026035, PMID:25026036]


An activity that faciliates the formation of a complementary double-stranded DNA molecule. [PMID:22888405, PMID:25520186]


protection of centromeric cohesion during meiotic anaphase I

The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions. [PMID:14730319, PMID:25533956]


A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone. [PMID:25598228]


microtubule anchoring at mitotic spindle pole body

Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. [PMID:17486116]


endoplasmic reticulum tubular network membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane. [PMID:20434336]


Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins. [PMID:20603077]


A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules. [GOC:kmv, PMID:2428682, PMID:26124290]


mitochondrial tRNA wobble position uridine thiolation

The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. [PMID:15509579]


The regrowth of a destroyed pancreas. [PMID:1985964]


A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light. [PMID:19883736]


A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer. [PMID:19883736]


The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells. [PMID:18495799]


substance P secretion, neurotransmission

The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter. [PMID:15292051]


cellular response to astrocyte-derived trophic factor

cellular response to glial cell derived neurotrophic factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. [PMID:20877310]


The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure. [PMID:18583150]


response to astrocyte-derived trophic factor

response to glial cell derived neurotrophic factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. [PMID:20877310]


thyroid gland epithelial cell proliferation

The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population. [PMID:17646383]


negative regulation of hedgehog target transcription factor

negative regulation of hh target transcription factor activity

Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling. [GOC:bhm, PMID:24311597]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. [PMID:10051633]


response to immobilization stress combined with water immersion

response to water-immersion restraint stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile. [PMID:10882227]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. [PMID:10051633]


Cytoplasm situated near, or occurring around, a phagosome. [PMID:18250451]


Binding to protein tyrosine kinase. [PMID:25499537]


response to immobilization stress combined with electrical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile. [PMID:17008368]


cytoplasmic side of dendritic spine plasma membrane

The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine. [PMID:9275233]


A process in which a protein is transported to, or maintained in, the cell periphery. [PMID:18216290]


A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph. [GOC:vesicles]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. [PMID:22982863]


The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins. [PMID:8679543]


The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity. [PMID:11278900]


clathrin-mediated extracellular exosome endocytosis

clathrin-dependent extracellular exosome endocytosis

The clathrin-mediated endocytosis of an extracellular exosome. [PMID:24951588]


small intestine smooth muscle contraction

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. [PMID:11991626]


The portion of an axon or dendrite that is close to the neuronal cell body. [PMID:21104189]


The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. [PMID:10807413]


The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle. [PMID:15937517]


A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. [PMID:24170253]


The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast. [PMID:19239477]


Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors. [PMID:23911909]


The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation. [GOC:vw]


osmolarity-sensing cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides. [PMID:18279313]


The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression. [PMID:15309047, PMID:26258632, PMID:26705896]


Binds to and increases the activity of a ubiquitin ligase. [GOC:dph, PMID:25619242]


protein binding, bridging involved in substrate recognition for ubiquitination

ubiquitin ligase-substrate adaptor activity

The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins. [PMID:24658274]


mitotic spindle microtubule depolymerisation

mitotic spindle microtubule depolymerization

The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle. [PMID:25253718]


The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression. [GOC:kmv, PMID:16352658, PMID:22552143, PMID:23750214, PMID:25898168]


Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. [GOC:pr]


The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [PMID:16203995]


polynucleotide adenylyltransferase activator activity

Increases the activity of the enzyme polynucleotide adenylyltransferase. [GOC:kmv, PMID:19460348]


Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw]


The regulated release of trypsinogen from the cells of the exocrine pancreas. [PMID:12771515]


A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein. [PMID:21930713]


The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. [PMID:22383759]


Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate. [EC:3.1.3.96, PMID:20722631]


response to manganese-induced ER stress
response to Mn-induced ER stress
manganese-induced ER stress response

response to manganese-induced endoplasmic reticulum stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus. [GOC:bf, GOC:PARL, PMID:23934647]


regulation of vascular smooth muscle cell membrane depolarization

regulation of vascular associated smooth muscle cell membrane depolarization

Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell. [PMID:20826763]


gamma-tubulin complex localisation to mitotic spindle pole body

establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body

gamma-tubulin complex localization to mitotic SPB

Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body. [GOC:dos, GOC:mah, PMID:11080156]


astral microtubule anchoring at mitotic spindle pole body

Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. [PMID:15004232]


A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation. [GOC:cjm, GOC:pr, PMID:23345319, Wikipedia:Pyrenoid]


DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair

UVDE-dependent excision repair, DNA incision

UV-damaged DNA endonuclease-dependent excision repair, DNA incision

DNA incision involved in UVDE-dependent excision repair

DNA incision involved in UV-damage excision repair

nucleic acid cleavage involved in UV-damage excision repair

A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). [PMID:10704216]


trehalose 6,6'-dimycolate receptor activity

Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:hjd, PMID:23602766]


up-regulation of homologous recombinational repair

upregulation of Rhp51-dependent recombinational repair

up regulation of homology-directed repair

up regulation of Rad51-dependent recombinational repair

up-regulation of homology-directed repair

up regulation of homologous recombinational repair

upregulation of homologous recombinational repair

up-regulation of Rad51-dependent recombinational repair

up-regulation of Rhp51-dependent recombinational repair

upregulation of Rad51-dependent recombinational repair

upregulation of double-strand break repair via homologous recombination

up regulation of Rhp51-dependent recombinational repair

up regulation of double-strand break repair via homologous recombination

upregulation of homology-directed repair

positive regulation of homologous recombinational repair

up-regulation of double-strand break repair via homologous recombination

positive regulation of Rad51-dependent recombinational repair

positive regulation of homology-directed repair

positive regulation of Rhp51-dependent recombinational repair

positive regulation of double-strand break repair via homologous recombination

Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination. [GO_REF:0000058, GOC:TermGenie, PMID:12023299]


up regulation of cellular protein degradation in lysosome

up-regulation of cellular protein catabolism in lysosome

up-regulation of cellular protein catabolic process in lysosome

upregulation of cellular protein catabolism in lysosome

upregulation of lysosomal protein catabolic process

positive regulation of cellular protein catabolic process in lysosome

up-regulation of cellular protein breakdown in lysosome

positive regulation of lysosomal protein catabolism

up-regulation of cellular protein degradation in lysosome

positive regulation of cellular protein catabolism in lysosome

up regulation of lysosomal protein catabolic process

upregulation of lysosomal protein degradation

up regulation of lysosomal protein catabolism

up-regulation of lysosomal protein catabolism

upregulation of cellular protein catabolic process in lysosome

positive regulation of cellular protein breakdown in lysosome

positive regulation of cellular protein degradation in lysosome

up regulation of cellular protein catabolic process in lysosome

up-regulation of lysosomal protein degradation

up regulation of cellular protein breakdown in lysosome

upregulation of lysosomal protein catabolism

upregulation of cellular protein breakdown in lysosome

up-regulation of lysosomal protein catabolic process

positive regulation of lysosomal protein degradation

up regulation of cellular protein catabolism in lysosome

upregulation of cellular protein degradation in lysosome

up regulation of lysosomal protein degradation

positive regulation of lysosomal protein catabolic process

Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]


down-regulation of lysosomal protein catabolic process

negative regulation of cellular protein catabolism in lysosome

down regulation of lysosomal protein catabolism

down-regulation of cellular protein catabolic process in lysosome

down regulation of lysosomal protein degradation

down regulation of cellular protein degradation in lysosome

downregulation of lysosomal protein degradation

downregulation of cellular protein degradation in lysosome

down regulation of cellular protein catabolism in lysosome

downregulation of cellular protein breakdown in lysosome

downregulation of cellular protein catabolism in lysosome

negative regulation of cellular protein catabolic process in lysosome

down-regulation of cellular protein breakdown in lysosome

downregulation of cellular protein catabolic process in lysosome

down regulation of cellular protein catabolic process in lysosome

down-regulation of lysosomal protein degradation

negative regulation of lysosomal protein degradation

downregulation of lysosomal protein catabolism

down-regulation of cellular protein degradation in lysosome

down regulation of cellular protein breakdown in lysosome

down regulation of lysosomal protein catabolic process

negative regulation of cellular protein breakdown in lysosome

negative regulation of lysosomal protein catabolism

down-regulation of lysosomal protein catabolism

downregulation of lysosomal protein catabolic process

negative regulation of cellular protein degradation in lysosome

down-regulation of cellular protein catabolism in lysosome

negative regulation of lysosomal protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]


regulation of cellular protein catabolic process in lysosome

regulation of cellular protein catabolism in lysosome

regulation of lysosomal protein degradation

regulation of cellular protein degradation in lysosome

regulation of lysosomal protein catabolism

regulation of cellular protein breakdown in lysosome

regulation of lysosomal protein catabolic process

Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937]


up regulation of phagosome maturation
upregulation of phagosome maturation
up-regulation of phagosome maturation

positive regulation of phagosome maturation

Any process that activates or increases the frequency, rate or extent of phagosome maturation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]


down regulation of phagosome maturation
down-regulation of phagosome maturation
downregulation of phagosome maturation

negative regulation of phagosome maturation

Any process that stops, prevents or reduces the frequency, rate or extent of phagosome maturation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]


Any process that modulates the frequency, rate or extent of phagosome maturation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16908865, PMID:23303671]


protein localisation in phagocytic vesicle

protein localisation to phagocytic vesicle

protein localization in phagocytic vesicle

protein localization to phagocytic vesicle

A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle. [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671]


up regulation of photosynthesis
up-regulation of photosynthesis
upregulation of photosynthesis

Any process that activates or increases the frequency, rate or extent of photosynthesis. [GO_REF:0000058, GOC:TermGenie, PMID:7592491]


Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis. [GO_REF:0000058, GOC:TermGenie, PMID:7592491]


up-regulation of membrane invagination
up regulation of membrane invagination
upregulation of membrane invagination

positive regulation of membrane invagination

Any process that activates or increases the frequency, rate or extent of membrane invagination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]


down regulation of membrane invagination

down-regulation of membrane invagination

negative regulation of membrane invagination

Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]


Any process that modulates the frequency, rate or extent of membrane invagination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]


positive regulation of voltage-sensitive sodium channel

positive regulation of voltage-dependent sodium channel activity

positive regulation of voltage gated sodium channel activity

positive regulation of voltage-gated sodium ion channel activity

positive regulation of voltage-gated sodium channel activity

Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:24198377]


negative regulation of voltage-dependent sodium channel activity

negative regulation of voltage-gated sodium ion channel activity

negative regulation of voltage-sensitive sodium channel

negative regulation of voltage gated sodium channel activity

negative regulation of voltage-gated sodium channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:24198377]


regulation of voltage-dependent sodium channel activity

regulation of voltage gated sodium channel activity

regulation of voltage-gated sodium ion channel activity

regulation of voltage-sensitive sodium channel

regulation of voltage-gated sodium channel activity

Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:24198377]


up-regulation of smooth muscle hypertrophy

upregulation of smooth muscle hypertrophy

up regulation of smooth muscle hypertrophy

positive regulation of smooth muscle hypertrophy

Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]


down-regulation of smooth muscle hypertrophy

down regulation of smooth muscle hypertrophy

downregulation of smooth muscle hypertrophy

negative regulation of smooth muscle hypertrophy

Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]


Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]


cellular protein degradation in lysosome

cellular protein catabolic process in lysosome

Any cellular protein catabolic process that takes place in a lysosome. [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]


eukaryotic translation initiation factor 2 complex formation

eukaryotic translation initiation factor 2 complex assembly

The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex. [GO_REF:0000079, GOC:TermGenie, PMID:23775072]


downregulation of apical ectodermal ridge formation

down regulation of apical ectodermal ridge formation

downregulation of apical epidermal ridge formation

down-regulation of apical ectodermal ridge formation

negative regulation of apical epidermal ridge formation

down regulation of apical epidermal ridge formation

down-regulation of apical epidermal ridge formation

negative regulation of apical ectodermal ridge formation

Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. [GO_REF:0000058, GOC:TermGenie, PMID:18359901]


The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583]


upregulation of viral DNA genome packaging via site-specific sequence recognition

up-regulation of viral DNA genome packaging via site-specific sequence recognition

up regulation of viral DNA genome packaging via site-specific sequence recognition

positive regulation of viral DNA genome packaging via site-specific sequence recognition

Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. [GO_REF:0000058, GOC:TermGenie, PMID:24711378]


regulation of viral DNA genome packaging via site-specific sequence recognition

Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. [GO_REF:0000058, GOC:TermGenie, PMID:24711378]


dethiobiotin import across plasma membrane

The directed movement of dethiobiotin from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:12557275]


The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:12557275]


up regulation of meiotic chromosome resolution

up regulation of meiotic chromosome separation

positive regulation of chromosome separation during meiosis

upregulation of meiotic chromosome separation

upregulation of meiotic chromosome resolution

up-regulation of meiotic chromosome resolution

up regulation of chromosome separation during meiosis

positive regulation of meiotic chromosome resolution

upregulation of chromosome separation during meiosis

up-regulation of chromosome separation during meiosis

up-regulation of meiotic chromosome separation

positive regulation of meiotic chromosome separation

Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]


downregulation of meiotic chromosome resolution

downregulation of meiotic chromosome separation

down-regulation of chromosome separation during meiosis

down regulation of meiotic chromosome resolution

downregulation of chromosome separation during meiosis

down-regulation of meiotic chromosome resolution

down regulation of meiotic chromosome separation

down-regulation of meiotic chromosome separation

down regulation of chromosome separation during meiosis

negative regulation of meiotic chromosome resolution

negative regulation of chromosome separation during meiosis

negative regulation of meiotic chromosome separation

Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]


regulation of meiotic chromosome resolution

regulation of chromosome separation during meiosis

regulation of meiotic chromosome separation

Any process that modulates the frequency, rate or extent of meiotic chromosome separation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]


carcinine transmembrane transporter activity

Enables the transfer of carcinine from one side of a membrane to the other. [GO_REF:0000070, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]


The directed movement of carcinine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]


endocannabinoid signalling pathway involved in trans-synaptic signaling by endocannabinoid

endocannabinoid signaling pathway involved in trans-synaptic signaling

Any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid. [GO_REF:0000060, GOC:TermGenie, PMID:23040807]


upregulation of axo-dendritic protein transport

up-regulation of axo-dendritic protein transport

up regulation of axo-dendritic protein transport

positive regulation of axo-dendritic protein transport

Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:20694152]


down-regulation of axo-dendritic protein transport

down regulation of axo-dendritic protein transport

downregulation of axo-dendritic protein transport

negative regulation of axo-dendritic protein transport

Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:20694152]


regulation of axo-dendritic protein transport

Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:20694152]


positive regulation of glucosylcerebrosidase activity

up regulation of ceramide glucosidase activity

positive regulation of glucosylsphingosine beta-D-glucosidase activity

upregulation of glucosylsphingosine beta-glucosidase activity

upregulation of glucosphingosine glucosylhydrolase activity

up-regulation of glucosphingosine glucosylhydrolase activity

up-regulation of glucosylcerebrosidase activity

up-regulation of beta-glucosylceramidase activity

positive regulation of GlcCer-beta-glucosidase activity

up regulation of glucosphingosine glucosylhydrolase activity

positive regulation of beta-glucocerebrosidase activity

up regulation of beta-glucosylceramidase activity

up regulation of glucosylsphingosine beta-glucosidase activity

up-regulation of glucosylceramidase activity

positive regulation of ceramide glucosidase activity

positive regulation of glucosylsphingosine beta-glucosidase activity

up-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

up-regulation of glucosylsphingosine beta-glucosidase activity

up regulation of glucosylceramidase activity

upregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

upregulation of beta-glucosylceramidase activity

upregulation of psychosine hydrolase activity

up regulation of beta-D-glucocerebrosidase activity

upregulation of ceramide glucosidase activity

up regulation of glucocerebrosidase activity

positive regulation of psychosine hydrolase activity

up regulation of glucosylcerebrosidase activity

positive regulation of beta-glucosylceramidase activity

upregulation of beta-D-glucocerebrosidase activity

positive regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

up-regulation of beta-glucocerebrosidase activity

upregulation of beta-glucocerebrosidase activity

up-regulation of beta-D-glucocerebrosidase activity

up regulation of beta-glucocerebrosidase activity

upregulation of glucosylcerebrosidase activity

positive regulation of glucosphingosine glucosylhydrolase activity

positive regulation of acid beta-glucosidase activity

up-regulation of glucosylsphingosine beta-D-glucosidase activity

upregulation of acid beta-glucosidase activity

upregulation of GlcCer-beta-glucosidase activity

up-regulation of glucocerebrosidase activity

upregulation of glucosylsphingosine beta-D-glucosidase activity

up-regulation of GlcCer-beta-glucosidase activity

up regulation of psychosine hydrolase activity

up-regulation of acid beta-glucosidase activity

up-regulation of psychosine hydrolase activity

upregulation of glucocerebrosidase activity

positive regulation of beta-D-glucocerebrosidase activity

up regulation of glucosylsphingosine beta-D-glucosidase activity

upregulation of glucosylceramidase activity

positive regulation of glucocerebrosidase activity

up regulation of GlcCer-beta-glucosidase activity

up regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

up regulation of acid beta-glucosidase activity

up-regulation of ceramide glucosidase activity

positive regulation of glucosylceramidase activity

Any process that activates or increases the frequency, rate or extent of glucosylceramidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]


down-regulation of beta-D-glucocerebrosidase activity

downregulation of glucosylsphingosine beta-D-glucosidase activity

downregulation of beta-glucocerebrosidase activity

down regulation of beta-glucosylceramidase activity

downregulation of beta-D-glucocerebrosidase activity

negative regulation of glucosphingosine glucosylhydrolase activity

negative regulation of beta-D-glucocerebrosidase activity

downregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

down-regulation of psychosine hydrolase activity

downregulation of glucosylsphingosine beta-glucosidase activity

down regulation of GlcCer-beta-glucosidase activity

downregulation of acid beta-glucosidase activity

negative regulation of acid beta-glucosidase activity

negative regulation of glucosylsphingosine beta-D-glucosidase activity

down-regulation of glucosylsphingosine beta-D-glucosidase activity

down regulation of glucosylceramidase activity

down regulation of glucosylsphingosine beta-D-glucosidase activity

downregulation of beta-glucosylceramidase activity

down regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

down-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

down-regulation of glucosylcerebrosidase activity

downregulation of glucosphingosine glucosylhydrolase activity

negative regulation of glucosylsphingosine beta-glucosidase activity

down-regulation of glucosylsphingosine beta-glucosidase activity

negative regulation of psychosine hydrolase activity

downregulation of glucosylcerebrosidase activity

down regulation of glucosphingosine glucosylhydrolase activity

negative regulation of beta-glucosylceramidase activity

down-regulation of glucosylceramidase activity

down-regulation of GlcCer-beta-glucosidase activity

down regulation of ceramide glucosidase activity

negative regulation of glucosylcerebrosidase activity

down regulation of beta-D-glucocerebrosidase activity

down regulation of glucosylsphingosine beta-glucosidase activity

downregulation of glucosylceramidase activity

down-regulation of ceramide glucosidase activity

downregulation of GlcCer-beta-glucosidase activity

negative regulation of GlcCer-beta-glucosidase activity

negative regulation of beta-glucocerebrosidase activity

down regulation of glucocerebrosidase activity

down-regulation of glucosphingosine glucosylhydrolase activity

downregulation of glucocerebrosidase activity

down regulation of psychosine hydrolase activity

downregulation of ceramide glucosidase activity

down regulation of glucosylcerebrosidase activity

negative regulation of ceramide glucosidase activity

negative regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

down regulation of beta-glucocerebrosidase activity

down regulation of acid beta-glucosidase activity

down-regulation of glucocerebrosidase activity

downregulation of psychosine hydrolase activity

down-regulation of acid beta-glucosidase activity

down-regulation of beta-glucosylceramidase activity

negative regulation of glucocerebrosidase activity

down-regulation of beta-glucocerebrosidase activity

negative regulation of glucosylceramidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of glucosylceramidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]


regulation of acid beta-glucosidase activity

regulation of glucocerebrosidase activity

regulation of glucosylsphingosine beta-glucosidase activity

regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity

regulation of psychosine hydrolase activity

regulation of GlcCer-beta-glucosidase activity

regulation of glucosylsphingosine beta-D-glucosidase activity

regulation of ceramide glucosidase activity

regulation of glucosylcerebrosidase activity

regulation of beta-glucocerebrosidase activity

regulation of beta-glucosylceramidase activity

regulation of beta-D-glucocerebrosidase activity

regulation of glucosphingosine glucosylhydrolase activity

regulation of glucosylceramidase activity

Any process that modulates the frequency, rate or extent of glucosylceramidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]


positive regulation of ribonucleoside-diphosphate reductase activity

Any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity. [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]


regulation of ribonucleotide diphosphate reductase activity

regulation of ribonucleoside-diphosphate reductase activity

Any process that modulates the frequency, rate or extent of ribonucleoside-diphosphate reductase activity. [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]


upregulation of lateral attachment of mitotic spindle microtubules to kinetochore

up-regulation of lateral attachment of mitotic spindle microtubules to kinetochore

up regulation of lateral attachment of mitotic spindle microtubules to kinetochore

positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore

Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore. [GO_REF:0000058, GOC:TermGenie, PMID:22375062]


regulation of lateral attachment of mitotic spindle microtubules to kinetochore

Any process that modulates the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore. [GO_REF:0000058, GOC:TermGenie, PMID:22375062]


cell surface receptor signaling pathway involved in cell-cell signalling

cell surface receptor linked signaling pathway involved in cell-cell signaling

cell surface receptor linked signalling pathway involved in cell-cell signaling

cell surface receptor linked signaling pathway involved in cell-cell signalling

cell surface receptor linked signal transduction involved in cell-cell signalling

cell surface receptor linked signal transduction involved in cell-cell signaling

cell surface receptor linked signalling pathway involved in cell-cell signalling

cell surface receptor signaling pathway involved in cell-cell signaling

Any cell surface receptor signaling pathway that is involved in cell-cell signaling. [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0]


up regulation of pulmonary blood vessel remodeling

up-regulation of pulmonary blood vessel remodeling

upregulation of pulmonary blood vessel remodeling

positive regulation of pulmonary blood vessel remodeling

Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]


down regulation of pulmonary blood vessel remodeling

downregulation of pulmonary blood vessel remodeling

down-regulation of pulmonary blood vessel remodeling

negative regulation of pulmonary blood vessel remodeling

Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]


regulation of pulmonary blood vessel remodeling

Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]


Binding to guanosine. [GO_REF:0000067, GOC:TermGenie, PMID:26007660]


integral component of lysosomal membrane

The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GO_REF:0000064, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26134396]


positive regulation of apoptosome formation

positive regulation of apoptosome assembly

Any process that activates or increases the frequency, rate or extent of apoptosome assembly. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]


negative regulation of apoptosome formation

negative regulation of apoptosome assembly

Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]


Any process that modulates the frequency, rate or extent of apoptosome assembly. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]


positive regulation of guanyl-nucleotide releasing factor

up-regulation of guanyl-nucleotide releasing factor

up regulation of guanyl-nucleotide releasing factor

upregulation of guanyl-nucleotide releasing factor

up-regulation of guanyl-nucleotide exchange factor activity

positive regulation of guanyl-nucleotide release factor activity

up regulation of guanyl-nucleotide exchange factor activity

up regulation of GDP-dissociation stimulator activity

positive regulation of GDP-dissociation stimulator activity

up-regulation of guanyl-nucleotide release factor activity

upregulation of guanyl-nucleotide exchange factor activity

upregulation of GDP-dissociation stimulator activity

upregulation of guanyl-nucleotide release factor activity

up regulation of guanyl-nucleotide release factor activity

up-regulation of GDP-dissociation stimulator activity

positive regulation of guanyl-nucleotide exchange factor activity

Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity. [GO_REF:0000059, GOC:TermGenie, PMID:20484009]


down regulation of GDP-dissociation stimulator activity

negative regulation of GDP-dissociation stimulator activity

down regulation of guanyl-nucleotide exchange factor activity

negative regulation of guanyl-nucleotide releasing factor

down-regulation of guanyl-nucleotide release factor activity

down regulation of guanyl-nucleotide releasing factor

downregulation of guanyl-nucleotide release factor activity

negative regulation of guanyl-nucleotide release factor activity

down-regulation of GDP-dissociation stimulator activity

down-regulation of guanyl-nucleotide exchange factor activity

downregulation of guanyl-nucleotide releasing factor

downregulation of GDP-dissociation stimulator activity

down regulation of guanyl-nucleotide release factor activity

downregulation of guanyl-nucleotide exchange factor activity

down-regulation of guanyl-nucleotide releasing factor

negative regulation of guanyl-nucleotide exchange factor activity

Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity. [GO_REF:0000059, GOC:TermGenie, PMID:20484009]


regulation of GDP-dissociation stimulator activity

regulation of guanyl-nucleotide release factor activity

regulation of guanyl-nucleotide releasing factor

regulation of guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity. [GO_REF:0000059, GOC:TermGenie, PMID:20484009]


positive regulation of apolipoprotein A-I-mediated signalling pathway

upregulation of apolipoprotein A-I-mediated signaling pathway

up regulation of apolipoprotein A-I-mediated signalling pathway

upregulation of apolipoprotein A-I-mediated signalling pathway

up-regulation of apolipoprotein A-I-mediated signalling pathway

up-regulation of apolipoprotein A-I-mediated signaling pathway

up regulation of apolipoprotein A-I-mediated signaling pathway

positive regulation of apolipoprotein A-I-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]


down-regulation of apolipoprotein A-I-mediated signaling pathway

down regulation of apolipoprotein A-I-mediated signaling pathway

down-regulation of apolipoprotein A-I-mediated signalling pathway

downregulation of apolipoprotein A-I-mediated signalling pathway

downregulation of apolipoprotein A-I-mediated signaling pathway

down regulation of apolipoprotein A-I-mediated signalling pathway

negative regulation of apolipoprotein A-I-mediated signalling pathway

negative regulation of apolipoprotein A-I-mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]


regulation of apolipoprotein A-I-mediated signalling pathway

regulation of apolipoprotein A-I-mediated signaling pathway

Any process that modulates the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]


Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus. [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus. [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]


positive regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization

up regulation of parkin-mediated mitophagy in response to mitochondrial depolarization

upregulation of parkin-mediated mitophagy in response to mitochondrial depolarization

positive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization

up-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]


downregulation of parkin-mediated mitophagy in response to mitochondrial depolarization

down regulation of parkin-mediated mitophagy in response to mitochondrial depolarization

negative regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization

down-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Any process that stops, prevents or reduces the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]


regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Any process that modulates the frequency, rate or extent of a parkin-mediated process that positively regulates mitophagy in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]


upregulation of synaptonemal complex formation

positive regulation of synaptonemal complex formation

up regulation of synaptonemal complex assembly

up regulation of synaptonemal complex formation

upregulation of synaptonemal complex assembly

up-regulation of synaptonemal complex formation

up-regulation of synaptonemal complex assembly

positive regulation of synaptonemal complex assembly

Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24797370]


upregulation of bioluminescence
up-regulation of bioluminescence
up regulation of bioluminescence

Any process that activates or increases the frequency, rate or extent of bioluminescence. [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]


down regulation of bioluminescence
downregulation of bioluminescence
down-regulation of bioluminescence

Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence. [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]


Any process that modulates the frequency, rate or extent of bioluminescence. [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]


upregulation of mitochondrial translational elongation

upregulation of mitochondrial translation elongation

up regulation of mitochondrial translational elongation

positive regulation of mitochondrial translation elongation

up-regulation of mitochondrial translation elongation

up regulation of mitochondrial translation elongation

up-regulation of mitochondrial translational elongation

positive regulation of mitochondrial translational elongation

Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation. [GO_REF:0000058, GOC:TermGenie, PMID:25738458]


down-regulation of mitochondrial translation elongation

downregulation of mitochondrial translational elongation

downregulation of mitochondrial translation elongation

down regulation of mitochondrial translation elongation

negative regulation of mitochondrial translation elongation

down-regulation of mitochondrial translational elongation

down regulation of mitochondrial translational elongation

negative regulation of mitochondrial translational elongation

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation. [GO_REF:0000058, GOC:TermGenie, PMID:25738458]


regulation of mitochondrial translation elongation

regulation of mitochondrial translational elongation

Any process that modulates the frequency, rate or extent of mitochondrial translational elongation. [GO_REF:0000058, GOC:TermGenie, PMID:25738458]


upregulation of cerebellar neuron development

up-regulation of cerebellar neuron development

up regulation of cerebellar neuron development

positive regulation of cerebellar neuron development

Any process that activates or increases the frequency, rate or extent of cerebellar neuron development. [GO_REF:0000058, GOC:TermGenie, PMID:26609159]


down-regulation of cerebellar neuron development

downregulation of cerebellar neuron development

down regulation of cerebellar neuron development

negative regulation of cerebellar neuron development

Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development. [GO_REF:0000058, GOC:TermGenie, PMID:26609159]


regulation of cerebellar neuron development

Any process that modulates the frequency, rate or extent of cerebellar neuron development. [GO_REF:0000058, GOC:TermGenie, PMID:26609159]


up-regulation of occluding cell junction disassembly

up regulation of occluding cell junction disassembly

positive regulation of occluding junction disassembly

upregulation of tight junction disassembly

positive regulation of occluding cell junction disassembly

upregulation of occluding cell junction disassembly

up-regulation of tight junction disassembly

up regulation of tight junction disassembly

positive regulation of tight junction disassembly

Any process that activates or increases the frequency, rate or extent of tight junction disassembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]


downregulation of occluding cell junction disassembly

negative regulation of occluding cell junction disassembly

down regulation of occluding cell junction disassembly

downregulation of occluding junction disassembly

down-regulation of tight junction disassembly

downregulation of tight junction disassembly

down regulation of tight junction disassembly

down-regulation of occluding cell junction disassembly

negative regulation of tight junction disassembly

Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]


regulation of occluding junction disassembly

regulation of occluding cell junction disassembly

regulation of tight junction disassembly

Any process that modulates the frequency, rate or extent of tight junction disassembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]


The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure. The cardiac jelly is an acellular gelatinous matrix secreted by the myocardium and plays a central role in the septation of the heart. [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10645959, PMID:16314491, PMID:19703439]


occluding cell junction disassembly
occluding junction disassembly

The disaggregation of an tight junction into its constituent components. [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]


anterior visceral endoderm cell migration

The orderly movement of an anterior visceral endoderm cell from one site to another. [GO_REF:0000091, GOC:TermGenie, PMID:17078044]


The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579]


positive regulation of canonical Wnt receptor signalling pathway involved in heart development

positive regulation of canonical Wnt receptor signaling pathway involved in heart development

positive regulation of canonical Wnt-activated signaling pathway involved in heart development

positive regulation of canonical Wnt signaling pathway involved in heart development

Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]


negative regulation of canonical Wnt receptor signalling pathway involved in heart development

down-regulation of canonical Wnt receptor signaling pathway involved in heart development

down regulation of canonical Wnt signaling pathway involved in heart development

downregulation of canonical Wnt signaling pathway involved in heart development

down-regulation of canonical Wnt receptor signalling pathway involved in heart development

down regulation of canonical Wnt-activated signaling pathway involved in heart development

negative regulation of canonical Wnt receptor signaling pathway involved in heart development

downregulation of canonical Wnt receptor signalling pathway involved in heart development

down regulation of canonical Wnt receptor signaling pathway involved in heart development

down-regulation of canonical Wnt-activated signaling pathway involved in heart development

down regulation of canonical Wnt receptor signalling pathway involved in heart development

downregulation of canonical Wnt-activated signaling pathway involved in heart development

down-regulation of canonical Wnt signaling pathway involved in heart development

downregulation of canonical Wnt receptor signaling pathway involved in heart development

negative regulation of canonical Wnt-activated signaling pathway involved in heart development

negative regulation of canonical Wnt signaling pathway involved in heart development

Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]