Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. [GOC:mah, GOC:signaling]


Mo-molybdopterin cofactor sulphurase activity

molybdopterin synthase sulfurylase activity

Mo-molybdopterin cofactor sulfurase activity

Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase. [GOC:mah, PMID:11549764]


Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. [PMID:18154309, PMID:8514783]


Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala. [MetaCyc:RXN0-5225]


Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate. [MetaCyc:NANE-RXN]


Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+. [MetaCyc:R465-RXN]


Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide. [GOC:jl, PMID:12045108]


Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]


Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O. [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN]


3-KSR activity
3-keto-steroid reductase activity

Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+). [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880]


NADPH-dependent aldo-keto reductase activity

Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. [GOC:ai]


Catalysis of the interconversion of arsenate and arsenite. [GOC:mah]


arsenate reductase (glutaredoxin) activity

Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. [EC:1.20.4.1, GOC:kd, PMID:10593884]


arsenate reductase (thioredoxin) activity

Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin. [MetaCyc:RXN-10737]


Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN]


C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity

Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. [EC:1.1.1.170, PMID:9811880]


chlorite dismutase activity
chlorite O2-lyase activity

Catalysis of the reaction: chloride + O(2) = chlorite. [EC:1.13.11.49, RHEA:21404]


Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate. [EC:1.14.20.1, RHEA:20748]

deacetoxycephalosporin C synthetase activity


N-ribosyldihydronicotinamide dehydrogenase (quinone) activity

Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. [RHEA:12364]

dihydronicotinamide riboside quinone reductase activity


Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide. [GOC:mah, PMID:1745247, PMID:6815189]


Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. [GOC:curators]


glutathione disulphide oxidoreductase activity

glutathione disulfide oxidoreductase activity

Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. [GOC:mah]


Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid. [PMID:11711071]


Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. [PMID:9492312]


Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. [RHEA:11436]


cytochrome bo3 ubiquinol oxidase activity

Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]. [RHEA:30251]


(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)

hydroxymethylbutenyl pyrophosphate reductase activity

Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate. [GOC:js, PMID:11818558]


Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]


Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene. [UM-BBD_reactionID:r0491]


Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate. [UM-BBD_reactionID:r0736]


Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O. [EC:1.14.13.20]


Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+). [EC:1.14.13.10, RHEA:16917]


Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate. [UM-BBD_reactionID:r0252]


Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA. [UM-BBD_reactionID:r0430]


Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol. [UM-BBD_reactionID:r0081]


Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+). [EC:1.14.13.23, RHEA:11480]


Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+). [EC:1.14.13.24, RHEA:22692]


Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. [EC:1.14.13.-]


4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)

Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2. [EC:1.14.13.27]


4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)

Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2. [EC:1.14.13.64]


p-hydroxybenzoic acid hydroxylase activity

Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O. [EC:1.14.13.2]

p-hydroxybenzoic acid hydrolase activity


4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))

4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity

Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O. [EC:1.14.13.33]


Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O. [EC:1.14.13.18]


Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone. [RHEA:34327]


6-hydroxy pseudo-oxynicotine monooxygenase activity

Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine. [UM-BBD_reactionID:r0480]


Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. [UM-BBD_reactionID:r0048]


fatty acid (omega-1)-hydroxylase activity

Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. [EC:1.14.15.3]


Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O. [EC:1.14.13.69]


alpha-pinene monooxygenase [NADH] activity

Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide. [UM-BBD_reactionID:r0742]


anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)

anthranilate hydroxylase (deaminating) activity

anthranilate 3-monooxygenase (deaminating) activity

Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+). [EC:1.14.13.35, RHEA:21236]

anthranilate 2,3-hydroxylase (deaminating) activity


Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+. [EC:1.14.13.40]

anthraniloyl coenzyme A reductase activity


Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+). [EC:1.14.14.92, RHEA:18033]


2,5-diketocamphane lactonizing enzyme activity

Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O. [PMID:3944058, PMID:8515237, RHEA:34415]


(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)

camphor 5-exo-methylene hydroxylase activity

Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O. [EC:1.14.15.1]


Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide. [UM-BBD_reactionID:r0599]


Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol. [UM-BBD_enzymeID:e0252]


CMP-N-acetylneuraminic acid hydroxylase activity

cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O. [EC:1.14.18.2]

cytidine monophosphoacetylneuraminate monooxygenase activity


cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity

Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O. [EC:1.14.13.22]


Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine. [UM-BBD_reactionID:r0128]


Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine. [KEGG_REACTION:R05567]


Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O. [RHEA:49076]


Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate. [UM-BBD_reactionID:r0235]


dimethyl sulphide monooxygenase activity

Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde. [UM-BBD_reactionID:r0208]


dimethylaniline monooxygenase (N-oxide-forming) activity

Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. [EC:1.14.13.8]


Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+. [PMID:8692910, PMID:9880351]


FMNH(2)-dependent alkanesulfonate monooxygenase activity

FMNH(2)-dependent aliphatic sulfonate monooxygenase activity

alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity

FMNH2-dependent aliphatic sulfonate monooxygenase activity

Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. [MetaCyc:RXN0-280]


Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2. [PMID:11733005]


Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+). [EC:1.14.13.9, RHEA:20545]


Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide. [UM-BBD_enzymeID:e0462]


Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+). [EC:1.14.14.99, RHEA:15129]

(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity


(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity

(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity

(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity

Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O. [EC:1.14.14.51]


Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation. [GOC:bf]


Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O. [EC:1.14.13.25, PMID:10896210]


methanesulphonic acid monooxygenase activity

Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O. [EC:1.14.13.111]

methanesulfonic acid monooxygenase activity


Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. [PMID:4965136, RHEA:18117]


Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+). [EC:1.14.13.6, RHEA:19601]


pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)

Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride. [EC:1.14.13.50]


peptidylglycine alpha-amidating monooxygenase activity

peptidyl alpha-amidating enzyme activity

Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. [EC:1.14.17.3]


Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide. [UM-BBD_enzymeID:e0333]


Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide. [UM-BBD_reactionID:r0508]


Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. [UM-BBD_reactionID:r0495]


Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O. [EC:1.14.13.7]


Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate. [UM-BBD_reactionID:r0036]


Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. [PMID:4004813, RHEA:20273]


salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)

Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2. [EC:1.14.13.1]


squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity

Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). [RHEA:25282]


Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]


cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity

Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O. [EC:1.14.99.38, RHEA:21104]


cholesterol monooxygenase (side-chain-cleaving) activity

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.6]


alpha-ecdysone C-20 hydroxylase activity

Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O. [EC:1.14.99.22, RHEA:14021]


Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide. [UM-BBD_reactionID:r0225]


Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran. [UM-BBD_reactionID:r0017]


Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene. [RHEA:20349]


Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene. [UM-BBD_enzymeID:e0224]


Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene. [UM-BBD_enzymeID:e0225]


Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene. [UM-BBD_reactionID:r0296]


Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol. [RHEA:51024]


Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4]


tyrosine 3-monooxygenase activity
tyrosine hydroxylase activity
L-tyrosine hydroxylase activity
tyrosine 3-hydroxylase activity

Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.2]


Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol. [UM-BBD_enzymeID:e0172]


Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+. [MetaCyc:RXN0-5101]


NAD(P)H oxidase activity
NAD(P)H:oxygen oxidoreductase activity


Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. [GOC:ai, PMID:10806195]

superoxide-generating NAD(P)H oxidase activity


oxidoreductase activity, acting on CH-OH group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2. [UM-BBD_reactionID:r0032]


Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol. [UM-BBD_enzymeID:e0229]


Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O. [UM-BBD_reactionID:r0638]


Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N. [EC:1.21.3.1, RHEA:22428]


Catalysis of the reduction of a ketone group to form the corresponding alcohol. [GOC:curators]


Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. [GOC:ai, GOC:bf]


cytochrome-dependent D-(-)-lactate dehydrogenase activity

D-lactate ferricytochrome c oxidoreductase activity

D-lactate (cytochrome) dehydrogenase activity

D-(-)-lactic cytochrome c reductase activity

D-lactate dehydrogenase (cytochrome) activity

D-lactate-cytochrome c reductase activity

Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. [RHEA:13521]


L-lactic acid dehydrogenase activity
L-lactate dehydrogenase activity

Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. [EC:1.1.1.27, RHEA:23444]


L-lactate cytochrome c reductase activity

L-lactate cytochrome c oxidoreductase activity

L-lactate dehydrogenase (cytochrome) activity

L-lactate ferricytochrome c oxidoreductase activity

L(+)-lactate:cytochrome c oxidoreductase activity

Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. [RHEA:19909]


Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. [GOC:mah, ISBN:0582227089]


Catalysis of the reaction: (R)-malate + NAD(+) = CO(2) + NADH + pyruvate. [EC:1.1.1.83, RHEA:18365]

D-malate dehydrogenase (decarboxylating) activity


NAD-dependent malic dehydrogenase activity

NAD-linked malate dehydrogenase activity

NAD-specific malate dehydrogenase activity

NAD-dependent malate dehydrogenase activity

Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. [EC:1.1.1.37]


NADP-linked malate dehydrogenase activity

malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)

Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. [EC:1.1.1.82]


Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. [ISBN:0198506732]


malate dehydrogenase (decarboxylating) (NAD+) activity

malate dehydrogenase (oxaloacetate-decarboxylating) activity

Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. [EC:1.1.1.38, EC:1.1.1.39]

malate dehydrogenase (decarboxylating) activity


malate dehydrogenase (NADP, decarboxylating)

NADP-specific malate dehydrogenase activity

malate dehydrogenase (decarboxylating, NADP)

malate dehydrogenase (decarboxylating) (NADP+) activity

Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. [EC:1.1.1.40]


Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal. [UM-BBD_reactionID:r0710]


oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule. [GOC:ai]


oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor

oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule. [GOC:ai]


oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. [EC:1.1.1.-, GOC:ai]


DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity

Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH. [EC:1.1.1.75, RHEA:16517]


Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+). [EC:1.1.1.4]


2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity

Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH. [EC:1.1.1.267, RHEA:13717]


NAD-specific 15-hydroxyprostaglandin dehydrogenase activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)

Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. [EC:1.1.1.141]


Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH. [EC:1.1.1.169, RHEA:16233]


2-dehydropantolactone reductase (B-specific) activity

2-dehydropantoyl-lactone reductase (B-specific) activity

Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. [EC:1.1.1.214]


Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+. [EC:1.1.1.125]


Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+. [EC:1.1.1.60]

tartronate semialdehyde reductase (NADPH) activity


Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone. [UM-BBD_reactionID:r0018]


imidazol-5-yl lactate dehydrogenase activity

Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+. [EC:1.1.1.111]


beta-hydroxyacylcoenzyme A dehydrogenase activity

beta-hydroxyacyl-coenzyme A synthetase activity

L-3-hydroxyacyl CoA dehydrogenase activity

L-3-hydroxyacyl coenzyme A dehydrogenase activity

Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). [EC:1.1.1.35]


long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity

Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [EC:1.1.1.211, GOC:pde]


Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. [EC:1.1.1.30, RHEA:20521]


dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)

Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+. [EC:1.1.1.157]

beta-hydroxybutyryl coenzyme A dehydrogenase activity


Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. [EC:1.1.1.31]


Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH. [EC:1.1.1.259, RHEA:11168]


Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. [EC:1.1.1.85, RHEA:32271]


4-sulfobenzyl alcohol dehydrogenase activity

Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH. [EC:1.1.1.257, RHEA:24412]


Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+. [EC:1.1.1.104]


Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH. [EC:1.1.1.193, RHEA:17845]


Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane. [UM-BBD_reactionID:r0427]


Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH. [EC:1.1.1.241, RHEA:11736]


Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH. [EC:1.1.1.258, RHEA:14225]


gluconate 6-phosphate dehydrogenase activity

Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH. [EC:1.1.1.43]


Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+. [EC:1.1.1.256]


D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity

hydroxyacyl coenzyme-A dehydrogenase activity

acetoacetyl coenzyme A reductase activity

NADP-linked acetoacetyl CoA reductase activity

short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity

Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+. [EC:1.1.1.36]


Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. [EC:1.1.1.303, EC:1.1.1.304, MetaCyc:ACETOINDEHYDROG-RXN]


acyldihydroxyacetone phosphate reductase activity

palmitoyl dihydroxyacetone phosphate reductase activity

Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+). [EC:1.1.1.101]


alcohol:NADP dehydrogenase activity
aldehyde reductase (NADPH2) activity
aldehyde reductase (NADPH) activity
alcohol dehydrogenase (NADP+) activity

Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. [EC:1.1.1.2]


alcohol dehydrogenase activity, iron-dependent

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron. [EC:1.1.1.1, GOC:mah]


alcohol dehydrogenase activity, metal ion-independent

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion. [EC:1.1.1.1, GOC:mah]


alcohol dehydrogenase activity, zinc-dependent

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. [EC:1.1.1.1, GOC:mah]


nonspecific NADPH-dependent carbonyl reductase activity

NADPH2-dependent carbonyl reductase activity

Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. [EC:1.1.1.184]


Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH. [EC:1.1.1.243, RHEA:13629]


Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. [EC:1.1.1.195]


Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+. [EC:1.1.1.245]


D-arabinose 1-dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. [EC:1.1.1.117]


NAD-dependent D-galactose dehydrogenase activity

Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+. [EC:1.1.1.48]


methylglyoxal reductase (NADH-dependent) activity

Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+. [EC:1.1.1.78]


D-lactic acid dehydrogenase activity
D-lactic dehydrogenase activity

Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate. [EC:1.1.1.28, RHEA:16369]


Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH. [EC:1.1.1.9, RHEA:20433]


Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. [EC:1.1.1.219]


thymidine diphospho-4-ketorhamnose reductase activity

Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH. [EC:1.1.1.133, RHEA:21796]


Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA. [UM-BBD_reactionID:r0595]


Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH. [EC:1.1.1.57, RHEA:15729]


Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+. [EC:1.1.1.251]


guanosine diphosphate-4-keto-D-rhamnose reductase activity

Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed. [BRENDA:1.1.1.187, EC:1.1.1.187]


Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+. [EC:1.1.1.215, EC:1.1.1.69]


Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+. [EC:1.1.1.215]


D-gluconate:NAD(P)+ 5-oxidoreductase
5-keto-D-gluconate 5-reductase activity
5-ketogluconate reductase activity
5-ketogluconate 5-reductase activity
5-keto-D-gluconate reductase

Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+. [EC:1.1.1.69]


NADP-dependent glucose 6-phosphate dehydrogenase activity

glucose 6-phosphate dehydrogenase (NADP) activity

D-glucose 6-phosphate dehydrogenase activity

Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. [EC:1.1.1.49]


Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. [EC:1.1.1.29]


Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. [EC:1.1.1.23]


Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. [EC:1.1.1.3]


3-hydroxy-3-methylglutaryl coenzyme A reductase activity

3-hydroxy-3-methylglutaryl-coenzyme A reductase activity


Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. [PMID:29224355, RHEA:15989]

hydroxymethylglutaryl-CoA reductase (NADPH) activity


Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+. [EC:1.1.1.81]


inosine monophosphate oxidoreductase activity

inosine 5'-monophosphate dehydrogenase activity

Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. [EC:1.1.1.205]

inosine monophosphate dehydrogenase activity


isocitrate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H. [GOC:curators]


NAD-specific isocitrate dehydrogenase activity

NAD dependent isocitrate dehydrogenase activity

isocitrate dehydrogenase (NAD+) activity

nicotinamide adenine dinucleotide isocitrate dehydrogenase activity

NAD-linked isocitrate dehydrogenase activity

Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH. [RHEA:23632]


NADP(+)-linked isocitrate dehydrogenase activity

NADP-dependent isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP-dependent) activity

isocitrate dehydrogenase (NADP) activity

isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity

NADP-dependent isocitric dehydrogenase activity

triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity

isocitrate (NADP) dehydrogenase activity

NADP-specific isocitrate dehydrogenase activity

NADP-linked isocitrate dehydrogenase activity

Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. [RHEA:19629]


Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH. [EC:1.1.1.223, RHEA:20860]


acetohydroxy acid isomeroreductase activity

acetohydroxy acid reductoisomerase activity

2-hydroxy-3-keto acid reductoisomerase activity

dihydroxyisovalerate dehydrogenase (isomerizing) activity

dihydroxyisovalerate (isomerizing) dehydrogenase activity

Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. [EC:1.1.1.86]


L-iditol:NAD+ 5-oxidoreductase activity
L-iditol 2-dehydrogenase activity
L-iditol:NAD oxidoreductase activity

Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. [EC:1.1.1.14]


Catalysis of the reaction: L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + CO(2) + NADH. [EC:1.1.1.103, RHEA:13161]


propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity

(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity

Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+. [EC:1.1.1.77]


mannitol:NAD+ 1-oxidoreductase activity
MTD activity

Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH. [EC:1.1.1.255, RHEA:15029]


Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. [EC:1.1.1.17]


Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor. [EC:1.1.1.32, EC:1.1.1.33]


Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH. [EC:1.1.1.32, RHEA:13221]


mevaldate reductase (NADPH) activity
(R)-mevalonate:NADP+ oxidoreductase

Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH. [EC:1.1.1.33, RHEA:20193]

mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase


1-octanol dehydrogenase activity
octanol:NAD+ oxidoreductase activity

Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH. [EC:1.1.1.73, RHEA:24620]


Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde. [EC:1.1.1.144, RHEA:10664]


phosphogluconic acid dehydrogenase activity

phosphogluconate dehydrogenase (decarboxylating) activity

Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. [EC:1.1.1.44]


3-phosphoglyceric acid dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. [EC:1.1.1.95]

glycerate 3-phosphate dehydrogenase activity


Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+. [EC:1.1.1.153]


D-sorbitol 6-phosphate dehydrogenase activity

Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. [EC:1.1.1.140]


Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. [GOC:mah]


11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity

Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+). [PMID:15761036]


testosterone dehydrogenase [NAD(P)] activity

3(or 17)beta-hydroxysteroid dehydrogenase activity

Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. [EC:1.1.1.51]


3-beta-hydroxy-5-ene steroid dehydrogenase activity

3beta-hydroxy steroid dehydrogenase/isomerase activity

3beta-hydroxy-5-ene steroid dehydrogenase activity

Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+). [EC:1.1.1.145]


7alpha-hydroxy steroid dehydrogenase activity


Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. [EC:1.1.1.62]


Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH. [EC:1.1.1.58, RHEA:17813]


mesotartrate dehydrogenase activity
tartrate:NAD+ oxidoreductase activity

Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+. [EC:1.1.1.93]


Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. [EC:1.1.1.22, RHEA:23596]


uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity

uridine diphosphoacetylpyruvoylglucosamine reductase activity

Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. [EC:1.3.1.98]


Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+. [EC:1.1.1.154, PMID:23284870]


xanthine oxidoreductase activity
xanthine-NAD oxidoreductase activity
NAD-xanthine dehydrogenase activity
xanthine:NAD+ oxidoreductase activity
xanthine dehydrogenase activity
xanthine/NAD+ oxidoreductase activity

Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. [EC:1.17.1.4]


oxidoreductase activity, acting on the CH-OH group of donors, other acceptors

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound. [GOC:ai]


quinoprotein alcohol dehydrogenase activity

alcohol dehydrogenase (acceptor) activity


Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. [EC:1.1.99.1, RHEA:17433]


glucose dehydrogenase (acceptor) activity

Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor. [PMID:22027299]


quinoprotein glucose dehydrogenase activity

glucose dehydrogenase (PQQ-dependent) activity

quinoprotein D-glucose dehydrogenase activity

Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol. [EC:1.1.5.2]

glucose dehydrogenase (pyrroloquinoline-quinone) activity


glycerol-3-phosphate dehydrogenase (quinone) activity

Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. [EC:1.1.5.3]


Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate. [EC:1.1.99.14, RHEA:21264]


Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene. [UM-BBD_reactionID:r0735]


oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule. [GOC:ai]


Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2. [RHEA:32183]

3beta-hydroxy steroid oxidoreductase activity


Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+). [EC:1.1.3.37, RHEA:23756]


Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide. [EC:1.1.3.9]


Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2. [EC:1.1.3.4, GOC:mah]


Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2). [EC:1.1.3.21, RHEA:18369]


fatty alcohol:oxygen oxidoreductase activity

Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O. [EC:1.1.3.20]

long-chain fatty alcohol oxidase activity


Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde. [MetaCyc:METHANOL-OXIDASE-RXN]


4-hydroxy-2-methoxybenzyl alcohol oxidase activity

Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin. [EC:1.1.3.38, RHEA:10036]

vanillyl alcohol:oxygen oxidoreductase activity


xanthine oxidoreductase activity
xanthine:O(2) oxidoreductase activity
xanthine:oxygen oxidoreductase activity
Schardinger enzyme activity
hypoxanthine-xanthine oxidase activity
xanthine oxidase activity
xanthine:xanthine oxidase activity

Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. [EC:1.17.3.2]


oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai]


Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-. [UM-BBD_reactionID:r0717]


Catalysis of the reduction of versicolorin A to sterigmatocystin. [PMID:1339261]


Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2). [EC:1.17.99.2, RHEA:17897]


oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor

oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. [GOC:ai]


ribonucleoside 5'-diphosphate reductase activity

ribonucleotide diphosphate reductase activity

Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. [GOC:dph, GOC:vw, PMID:16756507]


Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin. [EC:1.17.4.2]


oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. [GOC:ai]


p-cresol-(acceptor) oxidoreductase (hydroxylating) activity

4-cresol dehydrogenase (hydroxylating) activity

Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor. [EC:1.17.9.1]


Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol. [RHEA:51604]


oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. [GOC:ai]


oxidoreductase activity, acting on diphenols and related substances as donors

Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


ubiquinol-cytochrome c-2 oxidoreductase activity

ubiquinone-cytochrome c oxidoreductase activity

ubiquinone-cytochrome c reductase activity

ubiquinol-cytochrome c1 oxidoreductase activity

ubiquinol-cytochrome c2 reductase activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. [RHEA:11484]

ubiquinol-cytochrome c oxidoreductase activity


oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]


oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen. [GOC:jl]


oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]


Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product. [ISBN:0943088399]


o-diphenolase activity
catecholase
polyphenol oxidase activity
catechol oxidase activity
o-diphenol oxidoreductase

Catalysis of the reaction: 2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. [EC:1.10.3.1, PMID:22120533]


Catalysis of the reaction: 4 L-ascorbate + O(2) <=> 4 monodehydroascorbate + 2 H(2)O. [RHEA:30243]


OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. [EC:1.10.3.2]


oxidoreductase activity, acting on haem group of donors

oxidoreductase activity, acting on a heme group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor

oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group. [GOC:jl]


oxidoreductase activity, acting on heme group of donors, other acceptors

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen. [GOC:jl]


oxidoreductase activity, acting on hydrogen as donor

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor. [GOC:jl]


oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome. [GOC:jl]


oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor

oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein. [GOC:jl]


oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP. [GOC:jl]


chlorophyllide a:oxygen 7-oxidoreductase activity

Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O. [EC:1.13.12.14, MetaCyc:RXN-7676]


oxidoreductase activity, acting on hydrogen as donor, other acceptors

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound. [GOC:ai]


OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate. [EC:1.12.99.2]


oxidoreductase activity, acting on iron-sulphur proteins as donors

oxidoreductase activity, acting on iron-sulfur proteins as donors

Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide. [UM-BBD_reactionID:r0600]


Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. [PMID:15382920, RHEA:21448]

reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity


OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. [EC:1.18.6.1]


OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. [EC:1.18.6.1]


NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)

ferredoxin-nicotinamide adenine dinucleotide reductase activity

reductase, reduced nicotinamide adenine dinucleotide-ferredoxin

ferredoxin-linked NAD reductase activity

Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+. [RHEA:16521]

NADH-ferredoxinTOL reductase (component of toluene dioxygenase)


reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity

ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity

ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity

Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. [GOC:kd, RHEA:20125]


adrenodoxin-type ferredoxin reductase activity

Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+. [GOC:kd, RHEA:42312]


reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity

dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity

rubredoxin--nicotinamide adenine dinucleotide reductase activity

Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+. [RHEA:18597]


rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity

Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+. [EC:1.18.1.4]


oxidoreductase activity, acting on NADH or NADPH


Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+. [PMID:9555888]


Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. [UM-BBD_reactionID:r0684]


Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide. [RHEA:16757]


oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor

oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. [GOC:ai]


dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity

cytochrome-b5 reductase activity, acting on NAD(P)H

reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity

NADH-ferricytochrome b5 oxidoreductase activity

Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). [EC:1.6.2.2, ISBN:0198547684]


Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin. [EC:1.6.2.6]


Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. [EC:1.6.1.1, EC:1.6.1.2]


NAD(P) transhydrogenase (AB-specific) activity

NAD(P)+ transhydrogenase (AB-specific) activity

Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf]


NAD(P)+ transhydrogenase (B-specific) activity

NAD(P) transhydrogenase (B-specific) activity

Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+. [EC:1.6.1.1]


NADPH-cytochrome p-450 reductase activity

NADPH--cytochrome P450 reductase activity

NADPH:cytochrome P450 reductase activity

NADPH-cytochrome P-450 oxidoreductase activity

NADPH--cytochrome P450 oxidoreductase activity

Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. [EC:1.6.2.4]


oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor


Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene. [UM-BBD_reactionID:r0464]


Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate. [UM-BBD_reactionID:r0543]


guanosine 5'-monophosphate oxidoreductase activity

NADPH:GMP oxidoreductase (deaminating) activity

guanosine 5'-monophosphate reductase activity

guanosine 5'-phosphate reductase activity

guanosine monophosphate reductase activity

Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH. [EC:1.7.1.7, RHEA:17185]

NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity


Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative. [UM-BBD_enzymeID:e0346]


assimilatory NADH: nitrate reductase activity

assimilatory NADH:nitrate reductase activity

Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+. [EC:1.7.1.1]

NADH-dependent nitrate reductase activity


Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O. [MetaCyc:RXN-8815]


Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O. [RHEA:22024]


oxidoreductase activity, acting on NADH or NADPH, other acceptor

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen. [GOC:jl]


dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity

NADPH-specific dihydropteridine reductase activity

dihydropteridine reductase (NADH) activity

Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. [EC:1.5.1.34]


ferric chelate reductase activity
iron chelate reductase activity

Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. [PMID:33559753]


dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity

dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity

triphosphopyridine nucleotide diaphorase activity

flavoprotein NAD(P)H-quinone reductase activity

reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity

NAD(P)H dehydrogenase (quinone) activity

reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity

L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity

NAD(P)H(2) dehydrogenase (quinone) activity

Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor. [RHEA:13149]


beta-NADH dehydrogenase dinucleotide activity

reduced diphosphopyridine nucleotide diaphorase activity

dihydronicotinamide adenine dinucleotide dehydrogenase activity

dihydrocodehydrogenase I dehydrogenase activity

Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. [RHEA:11356]


reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase

Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol. [EC:1.6.5.10]


oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor


ascorbate free radical reductase activity

monodehydroascorbate reductase (NADH) activity

ascorbic free radical reductase activity

NADH:ascorbate radical oxidoreductase activity

ascorbate free-radical reductase activity

NADH:semidehydroascorbic acid oxidoreductase activity

Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate. [EC:1.6.5.4]


NADH dehydrogenase (ubiquinone) activity

dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity

Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out). [RHEA:29091]

reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity


Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. [EC:1.6.5.5]


p-benzoquinone reductase (NADPH) activity

Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+). [EC:1.6.5.6, RHEA:23488]


oxidoreductase activity, acting on other nitrogenous compounds as donors

Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]


nitrite reductase (cytochrome, ammonia-forming) activity

nitrite reductase (cytochrome; ammonia-forming)

Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+. [EC:1.7.2.2]


oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor

oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]


oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP. [GOC:jl]


nitrite:acceptor oxidoreductase
nitrate reductase activity
nitrite:(acceptor) oxidoreductase

Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. [EC:1.7.99.4]


Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide. [EC:1.7.2.5]


pentaerythritol tetranitrate reductase activity


oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]


Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative. [UM-BBD_enzymeID:e0038]


urate:oxygen oxidoreductase activity
uric acid oxidase activity
uricase activity

Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide. [EC:1.7.3.3]


oxidoreductase activity, acting on other substrates

OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized. [GOC:ai]


Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. [UM-BBD_reactionID:r0440]


1,2-dichloroethylene reductive dehalogenase activity

1,2-dichloroethene reductive dehalogenase activity

Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride. [UM-BBD_enzymeID:e0272]


Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate. [UM-BBD_reactionID:r0280]


2,5-dichlorohydroquinone reductive dehalogenase activity

Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone). [UM-BBD_enzymeID:e0366]


2-chloro-N-isopropylacetanilide reductive dehalogenase activity

Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide. [UM-BBD_reactionID:r0719]


Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene. [EC:1.97.1.2]


ribonucleotide reductase activating enzyme activity


vinyl chloride reductive dehalogenase activity

Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene. [UM-BBD_reactionID:r0352]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. [GOC:mah]


Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate. [UM-BBD_reactionID:r0619]


Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O. [PMID:27822549, PMID:4572721, RHEA:29407]


Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol. [UM-BBD_reactionID:r0281]


Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol. [UM-BBD_reactionID:r0231]


Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+). [EC:1.14.13.29, RHEA:12568]


Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol. [UM-BBD_reactionID:r0709]


Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol. [UM-BBD_reactionID:r0716]


Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions. [PMID:16347810]


Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin. [UM-BBD_reactionID:r0645]


Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol. [UM-BBD_reactionID:r0637]


Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol. [UM-BBD_reactionID:r0407]


Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol. [UM-BBD_reactionID:r0641]


methyl tertiary butyl ether 3-monooxygenase activity

Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde. [UM-BBD_reactionID:r1023]


Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol. [UM-BBD_reactionID:r0640]


Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin. [UM-BBD_reactionID:r0647]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]


deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity

deacetylcephalosporin C synthase activity

Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate. [EC:1.14.11.26, RHEA:16805]

deacetoxycephalosporin C hydroxylase activity


Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate. [EC:1.14.11.1, RHEA:24028]


gibberellin 2-oxidase activity
gibberellin 2beta-hydroxylase activity
gibberellin 2-beta-hydroxylase activity
gibberellin 2-beta-dioxygenase activity

Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2. [EC:1.14.11.13, GOC:kad]


Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones. [PMID:7604047]


gibberellin 3beta-hydroxylase activity
gibberellin 3-beta-dioxygenase activity
gibberellin 3beta-dioxygenase activity

Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2. [EC:1.14.11.15, GOC:kad]


naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity

Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2. [EC:1.14.11.9]


protocollagen lysyl hydroxylase activity

protocollagen lysine hydroxylase activity

protocollagen lysine dioxygenase activity

Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. [EC:1.14.11.4]


proline protocollagen hydroxylase activity

protocollagen prolyl hydroxylase activity

protocollagen proline dioxygenase activity

protocollagen proline 4-hydroxylase activity

procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity

Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. [GOC:mah, PMID:4371784]

protocollagen proline hydroxylase activity


procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity

prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity

protocollagen proline 3-hydroxylase activity

Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. [EC:1.14.11.7, RHEA:22872]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. [GOC:mah]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous

OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized. [GOC:ai]


4-methoxybenzoate monooxygenase (O-demethylating) activity

Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O. [EC:1.14.99.15, RHEA:18613]


acyl-[acyl-carrier protein] desaturase activity

stearyl acyl carrier protein desaturase activity

Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. [EC:1.14.19.2]

acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity


zeta-carotene desaturase activity
carotene 7,8-desaturase activity

Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O. [RHEA:30955]


acyl-CoA delta(11)-desaturase activity
acyl-CoA D11-desaturase activity

Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O. The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. [EC:1.14.19.5]


linoleoyl-coenzyme A desaturase activity

long-chain fatty acid delta6-desaturase activity

Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O. [PMID:12713571, PMID:7212717, RHEA:47140]

delta6-fatty acyl-CoA desaturase activity


linoleate delta12-fatty acid acetylenase (desaturase)

delta-12 fatty acid acetylenase activity

linoleate delta-12-fatty acid acetylenase (desaturase) activity

linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)

delta12-fatty acid dehydrogenase activity

Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O. [EC:1.14.99.33, RHEA:23456]


Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT. [UM-BBD_reactionID:r0450]


Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. [EC:1.14.99.29]


heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)

Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]. [RHEA:21764]


naphthalene disulphonate 1,2-dioxygenase activity

naphthalene disulfonate 1,2-dioxygenase activity

Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene). [UM-BBD_enzymeID:e0249]


Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain. [GOC:jl, PMID:9037020]


Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain. [PMID:7846158]


prostaglandin endoperoxide synthetase activity

Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. [EC:1.14.99.1]


Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. [RHEA:24785]


Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-. [UM-BBD_reactionID:r0447]


flavonoid 3'-monooxygenase activity
flavonoid 3'-hydroxylase activity
NADPH:flavonoid-3'-hydroxylase activity

Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. [EC:1.14.14.82]


Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene. [GOC:mah, PMID:820855]


cytochrome P450 cinnamate 4-hydroxylase activity

trans-cinnamic acid 4-hydroxylase activity

Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O. [EC:1.14.14.91]


Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone. [UM-BBD_reactionID:r0416]


Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin. [UM-BBD_reactionID:r0417]


2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)

Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol. [EC:1.14.12.14, RHEA:23468]


Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2. [EC:1.14.12.13]

2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)


Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone. [UM-BBD_reactionID:r0424]


Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+. [EC:1.14.12.16]


3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity

Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol. [UM-BBD_enzymeID:e0307]


4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity

4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity

Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol. [UM-BBD_reactionID:r0580]


4-aminobenzoate 3,4-dioxygenase (deaminating) activity

Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate. [UM-BBD_reactionID:r0566]


4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)

Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+). [EC:1.14.12.9, RHEA:14689]


4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)

Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite. [EC:1.14.12.8, RHEA:13937]


Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone. [UM-BBD_reactionID:r0409]


anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity

anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)

Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3. [EC:1.14.12.1]


benzene 1,2-dioxygenase activity
benzene dioxygenase activity

Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+). [EC:1.14.12.3, RHEA:13813]


Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol. [UM-BBD_reactionID:r0295]


Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+. [EC:1.14.12.10]

benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)


Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+. [EC:1.14.12.18]


Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene). [UM-BBD_enzymeID:e0062]


Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+. [MetaCyc:R606-RXN, RHEA:42460]


Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene. [UM-BBD_reactionID:r0160]


Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene. [UM-BBD_reactionID:r0247]


Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+. [EC:1.14.12.12]


nitric oxide,NAD(P)H:oxygen oxidoreductase activity

Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+. [EC:1.14.12.17]


Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol. [UM-BBD_reactionID:r0306]


Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+). [EC:1.14.12.7, RHEA:17489]


Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+). [EC:1.14.12.15, RHEA:10312]


Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate. [UM-BBD_enzymeID:e0190]


Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+). [EC:1.14.12.11, RHEA:16737]


Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate. [PMID:1254564, UM-BBD_reactionID:r0093]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O. [EC:1.14.15.7]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. [GOC:mah]


tert-butyl alcohol 2-monooxygenase activity

Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol. [UM-BBD_reactionID:r0615]


Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin. [UM-BBD_reactionID:r0643]


Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]. [RHEA:32443]


oxidoreductase activity, acting on peroxide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. [GOC:ai]


OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]


Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O. [EC:1.11.1.6]


myeloperoxidase activity
peroxidase activity
MPO
oxyperoxidase activity
peroxidase reaction

Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. [GOC:curators]


Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide. [EC:1.11.1.18]


Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O. [EC:1.11.1.10]


cytochrome c-H2O oxidoreductase activity

Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O. [EC:1.11.1.5]


Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O. [EC:1.11.1.14]


Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. [EC:1.11.1.9]


Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O. [RHEA:23336]


Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O. [EC:1.11.1.11]

L-ascorbic acid-specific peroxidase activity


Mn-dependent (NADH-oxidizing) peroxidase activity

Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O. [EC:1.11.1.13]


diphosphopyridine nucleotide peroxidase activity

nicotinamide adenine dinucleotide peroxidase activity

Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+). [EC:1.11.1.1, RHEA:18509]


TrxPx activity
TPx activity
thioredoxin peroxidase activity

Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. [RHEA:63528]


oxidoreductase activity, acting on phosphorus or arsenic in donors

Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:mah]


oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor

oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide. [GOC:mah]


oxidoreductase activity, acting on reduced flavodoxin as donor

Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen. [GOC:jl]


Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. [GOC:mah]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen


Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached. [UM-BBD_enzymeID:e0255]


Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate. [UM-BBD_enzymeID:e0309]


oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor. [GOC:mah]


Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. [GOC:mah]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen


Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate. [UM-BBD_reactionID:r0442]


Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate. [UM-BBD_reactionID:r0324]


Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate. [EC:1.13.11.38]

1-hydroxy-2-naphthoic acid dioxygenase activity


Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate. [UM-BBD_reactionID:r0457]


Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate). [UM-BBD_enzymeID:e0032]


2,3-dihydroxy DDT 1,2-dioxygenase activity

Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate. [UM-BBD_reactionID:r0452]


Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate. [UM-BBD_reactionID:r0310]


Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). [EC:1.13.11.14, RHEA:18477]


Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O. [EC:1.13.11.39]


Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate. [UM-BBD_enzymeID:e0422]


Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde. [UM-BBD_reactionID:r0305]


Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate. [UM-BBD_reactionID:r0501]


3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity

Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+). [EC:1.13.11.15, RHEA:15633]


Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate. [UM-BBD_reactionID:r0276]


3-hydroxyanthranilic acid dioxygenase activity

3-hydroxyanthranilic acid oxygenase activity

Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). [EC:1.13.11.6, RHEA:17953]


4-hydroxyphenylpyruvic acid dioxygenase activity

p-hydroxyphenylpyruvic acid hydroxylase activity

4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)

Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. [EC:1.13.11.27]


Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon. [UM-BBD_reactionID:r0049]


Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al. [EC:1.13.11.51]


Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. [EC:1.13.11.31, RHEA:10428]


arachidonic acid 5-lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. [EC:1.13.11.34, RHEA:32307]


Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal. [RHEA:32887]


Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol. [UM-BBD_reactionID:r0456]


Catalysis of the reaction: catechol + O2 = a muconate. [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN]


Catalysis of the reaction: catechol + O2 = cis,cis-muconate. [EC:1.13.11.1]


Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde. [EC:1.13.11.2]


Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate. [UM-BBD_reactionID:r0655]


Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+). [EC:1.13.11.20, RHEA:20441]


Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. [UM-BBD_reactionID:r0162]


Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid. [GOC:mah, UM-BBD_reactionID:r0415, UM-BBD_reactionID:r0422]


Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). [EC:1.13.11.5, RHEA:15449]


Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde. [UM-BBD_reactionID:r0228]


Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate. [EC:1.13.11.37]


Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. [EC:1.13.11.12, GOC:lb]


Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate. [RHEA:42344]


Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene. [UM-BBD_reactionID:r0455]


Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate. [EC:1.13.11.3]


protocatechuate 3,4-dioxygenase type II activity

Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate. [UM-BBD_reactionID:r0581]


Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde. [EC:1.13.11.8]


Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. [EC:1.13.11.24, RHEA:15381]


Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol. [UM-BBD_reactionID:r0256]


Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. [EC:1.13.11.11]


oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous

OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized. [GOC:ai]


Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol. [UM-BBD_reactionID:r0359]

2,4,5-trichlorophenoxyacetic acid oxygenase activity


oxidoreductase activity, acting on sulphur group of donors

oxidoreductase activity, acting on a sulfur group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor

oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]


oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. [GOC:jl]


acetylmethionine sulfoxide reductase activity

methyl sulfoxide reductase I and II activity

free-methionine (S)-S-oxide reductase activity

Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. [EC:1.8.4.13]


adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)

thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity

phosphoadenylyl-sulphate reductase (thioredoxin) activity

PAPS reductase, thioredoxin-dependent activity

phosphoadenylyl-sulfate reductase (thioredoxin) activity

Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. [EC:1.8.4.8, RHEA:11724]


protein disulfide transhydrogenase activity

glutathione-protein disulfide oxidoreductase activity

protein disulfide reductase (glutathione)

protein-disulfide reductase (glutathione) activity

thiol-protein disulphide oxidoreductase activity

reductase, protein disulfide (glutathione)

Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. [RHEA:21064]

protein-disulphide reductase (glutathione) activity


methionine sulphoxide reductase A activity

peptide methionine sulfoxide reductase activity

methionine sulfoxide (protein) reductase activity

methionine sulfoxide reductase A activity

peptide-methionine (S)-S-oxide reductase activity

methionine S-oxide reductase (S-form oxidizing) activity

Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920]

peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity


oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor

oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]


lipoamide oxidoreductase (NADH) activity

Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. [EC:1.8.1.4]


sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity

NADPH-dependent sulfite reductase activity

Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+. [RHEA:13801]


oxidoreductase activity, acting on sulfur group of donors, other acceptors

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome. [GOC:jl]


Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O. [UM-BBD_reactionID:r0207]


dissimilatory-type sulfite reductase activity

Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor. [EC:1.8.99.3]

dissimilatory sulfite reductase activity


assimilatory-type sulfite reductase activity

Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor. [GOC:curators]


tetrachlorohydroquinone reductive dehalogenase activity

tetrachloro-p-hydroquinone reductive dehalogenase activity

Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl. [UM-BBD_reactionID:r0314]


oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor

oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]


Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide. [EC:1.8.3.4]


sulphite oxidase activity
sulfite oxidase activity

Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate. [EC:1.8.3.1, RHEA:24600]


oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor

oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound. [GOC:jl]


oxidoreductase activity, acting on superoxide radicals as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor. [GOC:ai]


Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. [EC:1.15.1.1, GOC:vw, PMID:15064408]


oxidoreductase activity, acting on the aldehyde or oxo group of donors

Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate. [UM-BBD_reactionID:r0014]


Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid. [UM-BBD_reactionID:r0711]


oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]


carbon monoxide,water:cytochrome b-561 oxidoreductase activity

Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561. [GOC:curators, RHEA:48880]

carbon-monoxide dehydrogenase (cytochrome b-561)


oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. [GOC:jl]


3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity

dehydrogenase, 2-oxoisovalerate (lipoate) activity

3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

2-oxoisovalerate (lipoate) dehydrogenase activity

Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. [EC:1.2.4.4]


oxoglutarate dehydrogenase (succinyl-transferring) activity

2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)

2-oxoglutarate: lipoate oxidoreductase activity

oxoglutarate dehydrogenase (lipoamide) activity

alpha-ketoglutaric acid dehydrogenase activity

Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. [EC:1.2.4.2]

2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity


pyruvate dehydrogenase (acetyl-transferring) activity

pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)

pyruvate dehydrogenase (lipoamide) activity

pyranose dehydrogenase (acceptor) activity

quinone-dependent pyranose dehydrogenase activity

Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. [EC:1.2.4.1]

pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity


oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor

oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]


Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. [KEGG_REACTION:R01196]