central nervous system neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


central nervous system neuron development

The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


central nervous system neuron axonogenesis

Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


central nervous system interneuron axonogenesis

Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


CST axonogenesis
corticospinal tract axonogenesis

Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


dorsolateral tract of Lissauer morphogenesis

Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


spinal cord ventral commissure morphogenesis

The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


corticospinal neuron axon pathfinding through the cerebral cortex

corticospinal neuron axon guidance through the cerebral cortex

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


corticospinal neuron axon pathfinding through the internal capsule

corticospinal neuron axon guidance through the internal capsule

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


corticospinal neuron axon pathfinding through the cerebral peduncle

corticospinal neuron axon guidance through the cerebral peduncle

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


corticospinal neuron axon pathfinding through the basilar pons

corticospinal neuron axon guidance through the basilar pons

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


corticospinal neuron axon pathfinding through the medullary pyramid

corticospinal neuron axon guidance through the medullary pyramid

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


corticospinal neuron axon pathfinding through spinal cord

corticospinal neuron axon guidance through spinal cord

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


medulla reticulospinal tract morphogenesis

Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]


The differentiation of cells that will contribute to the structure and function of the hypothalamus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]


The orderly movement of cells from one site to another in the subpallium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


adenophysis development
anterior pituitary gland development
anterior pituitary development

The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


posterior pituitary gland development
neurophysis development
posterior pituitary development

The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:9780721601465]


The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586]


The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]


cell proliferation involved in neural plate elongation

The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]


The process in which closure points are established at multiple points and along the neural rostrocaudal axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The process in which the neural folds are fused extending from the initial closure points. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The process of joining together the neural folds at either end of the neural tube. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


neural plate mediolateral pattern formation

neural plate mediolateral regionalization

The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


forebrain induction by the anterior neural ridge

The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


down regulation of anterior neural cell fate of the neural plate

negative regulation of anterior neural cell fate of the neural plate

down-regulation of anterior neural cell fate of the neural plate

downregulation of anterior neural cell fate of the neural plate

negative regulation of anterior neural cell fate commitment of the neural plate

Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]


negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway

Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate

Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate

Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate

Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate

negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway

Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate

negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway

The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]


fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate

fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate

fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate

fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate

fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate

negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway

The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]


midbrain-hindbrain boundary maturation during brain development

A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]


midbrain-hindbrain boundary maturation during neural plate development

A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]


The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11425897, PMID:16452095]


convergent extension involved in neural plate elongation

The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]


The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


myelination in peripheral nervous system

The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


subpallium cell proliferation in forebrain

The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


lateral ganglionic eminence cell proliferation

The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


dorsal lateral ganglionic eminence cell proliferation

The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


medial ganglionic eminence cell proliferation

The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


caudal ganglionic eminence cell proliferation

The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The multiplication or reproduction of septal cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


radial glial cell fate commitment in forebrain

The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment

bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment

BMP signalling pathway involved in forebrain neuron fate commitment

BMP signaling pathway involved in forebrain neuron fate commitment

The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment

leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment

The series of molecular signals initiated by the binding of leukemia inhibitory factor to its receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:signaling]


epidermal growth factor signalling pathway involved in forebrain neuron fate commitment

epidermal growth factor signaling pathway involved in forebrain neuron fate commitment

The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


tangential migration from the subventricular zone to the olfactory bulb

The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The orderly movement of a cell from one site to another at least one of which is located in the telencephalon. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]


The orderly movement of glial cells through the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The orderly movement of an astrocyte cell through the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


telencephalon oligodendrocyte cell migration

The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The orderly movement of microglial cells through the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700]


The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]


The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]


regulation of rhodopsin mediated signalling

regulation of rhodopsin mediated signaling pathway

Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. [GOC:mah]


The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. [GOC:isa_complete, GOC:mtg_cell_cycle]


A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin. [GOC:isa_complete]


A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. [GOC:isa_complete]


The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. [GOC:isa_complete, PMID:27875684]


Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete]


up regulation of cell-cell adhesion
up-regulation of cell-cell adhesion
upregulation of cell-cell adhesion

positive regulation of cell-cell adhesion

Any process that activates or increases the rate or extent of cell adhesion to another cell. [GOC:isa_complete]


A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. [GOC:isa_complete]


reproductive cellular process in multicellular organism

cellular process involved in reproduction in multicellular organism

A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. [GOC:isa_complete]


reproductive process in single-celled organism

A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism. [GOC:isa_complete]


The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. [GOC:isa_complete]


The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur. [GOC:dph, GOC:isa_complete, GOC:jid]


regulation of anatomical structure morphogenesis

Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. [GOC:mah]


Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. [GOC:isa_complete]


A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell. [GOC:isa_complete, GOC:mtg_sensu]


establishment of proximal/distal cell polarity

The specification and formation of the polarity of a cell along its proximal/distal axis. [GOC:isa_complete]


The attachment of a multicellular organism to a substrate or other organism. [GOC:isa_complete]


multicellular organism adhesion to substrate

The attachment of a multicellular organism to a surface or material. [GOC:isa_complete]


A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated. [GOC:isa_complete, GOC:PO_curators, PO_REF:00009]


The process in which the anatomical structures of a gland are generated and organized. [GOC:isa_complete]


ribonucleoprotein complex biogenesis and assembly

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. [GOC:isa_complete, GOC:mah]


The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere. [GOC:isa_complete]


The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere. [GOC:isa_complete]


The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. [GOC:isa_complete, GOC:mah]


A process that results in the breakdown of the extracellular matrix. [GOC:jid]


RNA-protein complex assembly
protein-RNA complex assembly
RNP complex assembly

The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. [GOC:jl]


The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte. [GOC:isa_complete]


The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure. [GOC:isa_complete]


nucleus fragmentation
apoptotic nuclear fragmentation

nuclear fragmentation involved in apoptotic nuclear change

The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976]


The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. [GOC:ems, ISBN:0140512888]


The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. [GOC:mah]


dimeric RNase P complex
dimeric RNase P complex location
dimeric ribonuclease P complex location

A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species. [GOC:mah, PMID:12045094]


multimeric ribonuclease P complex location

A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species. [GOC:mah, PMID:11142368, PMID:12045094]


A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation. [GOC:vw, PMID:15572668, PMID:19474789]


aggregation during fruiting body development

aggregate development involved in sorocarp development

aggregation involved in sorocarp development

The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]


culmination during fruiting body development

culmination involved in sorocarp development

The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development. [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]


regulation of aggregation during fruiting body biosynthesis


The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:mah]


Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units. [EC:3.2.1.74, GOC:mlg]


type I hypersensitivity mediated by mast cells

An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. [GOC:add, ISBN:0781735149]


type I hypersensitivity mediated by basophils

An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. [GOC:add, ISBN:0781735149]


Any process involved in the carrying out of an immune response by a basophil. [GOC:add, ISBN:0781735149]


The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil. [GOC:add, ISBN:0781735149]


somatic diversification of immune receptors via germline recombination within a single locus

The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]


somatic diversification of immune receptors via alternate splicing

The process in which immune receptor genes are diversified through alternate splicing. [GOC:add, ISBN:0781735149, PMID:16166509]


alternate splicing of immunoglobulin genes

The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons. [ISBN:0781735149, PMID:9185563]


somatic diversification of immune receptors via gene conversion

The process in which immune receptor genes are diversified through gene conversion. [GOC:add, ISBN:0781735149]


somatic diversification of immune receptors via somatic mutation

The process in which immune receptor genes are diversified through somatic mutation. [ISBN:0781735149, PMID:16102575]


somatic diversification of FREP-based immune receptors

The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails. [GOC:add, PMID:16102575]


somatic diversification of T cell receptor genes

The somatic process that results in the generation of sequence diversity of T cell receptor genes. [GOC:add, ISBN:0781735149]


somatic diversification of immune receptors by N region addition

The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene. [GOC:add, ISBN:0781735149]


somatic diversification of antibody genes by N region addition

somatic diversification of immunoglobulin genes by N region addition

The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. [GOC:add, ISBN:0781735149]


somatic diversification of TCR genes by N region addition

somatic diversification of T cell receptor genes by N region addition

The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene. [GOC:add, ISBN:0781735149]


The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. [GOC:add, ISBN:0781735149]


The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. [GOC:add, PMID:16551251]


The movement of a basophil in response to an external stimulus. [GOC:add, PMID:11292027]


The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. [GOC:add]


regulation of antigen processing and presentation

Any process that modulates the frequency, rate, or extent of antigen processing and presentation. [GOC:add]


down-regulation of antigen processing and presentation

downregulation of antigen processing and presentation

down regulation of antigen processing and presentation

negative regulation of antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. [GOC:add]


up regulation of antigen processing and presentation

up-regulation of antigen processing and presentation

upregulation of antigen processing and presentation

positive regulation of antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. [GOC:add]


regulation of peptide or polysaccharide antigen processing and presentation via MHC class II

regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. [GOC:add]


negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II

down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. [GOC:add]


up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II

up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. [GOC:add]


regulation of peptide antigen processing and presentation

regulation of antigen processing and presentation of peptide antigen

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. [GOC:add]


down regulation of antigen processing and presentation of peptide antigen

down-regulation of antigen processing and presentation of peptide antigen

negative regulation of peptide antigen processing and presentation

downregulation of antigen processing and presentation of peptide antigen

negative regulation of antigen processing and presentation of peptide antigen

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen. [GOC:add]


positive regulation of peptide antigen processing and presentation

up-regulation of antigen processing and presentation of peptide antigen

upregulation of antigen processing and presentation of peptide antigen

up regulation of antigen processing and presentation of peptide antigen

positive regulation of antigen processing and presentation of peptide antigen

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen. [GOC:add]


regulation of peptide antigen processing and presentation via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class II

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. [GOC:add]


negative regulation of peptide antigen processing and presentation via MHC class II

down regulation of antigen processing and presentation of peptide antigen via MHC class II

down-regulation of antigen processing and presentation of peptide antigen via MHC class II

downregulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. [GOC:add]


positive regulation of peptide antigen processing and presentation via MHC class II

upregulation of antigen processing and presentation of peptide antigen via MHC class II

up regulation of antigen processing and presentation of peptide antigen via MHC class II

up-regulation of antigen processing and presentation of peptide antigen via MHC class II

positive regulation of antigen processing and presentation of peptide antigen via MHC class II

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. [GOC:add]


regulation of peptide antigen processing and presentation via MHC class I

regulation of antigen processing and presentation of peptide antigen via MHC class I

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. [GOC:add]


downregulation of antigen processing and presentation of peptide antigen via MHC class I

negative regulation of peptide antigen processing and presentation via MHC class I

down regulation of antigen processing and presentation of peptide antigen via MHC class I

down-regulation of antigen processing and presentation of peptide antigen via MHC class I

negative regulation of antigen processing and presentation of peptide antigen via MHC class I

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. [GOC:add]


upregulation of antigen processing and presentation of peptide antigen via MHC class I

positive regulation of peptide antigen processing and presentation via MHC class I

up-regulation of antigen processing and presentation of peptide antigen via MHC class I

up regulation of antigen processing and presentation of peptide antigen via MHC class I

positive regulation of antigen processing and presentation of peptide antigen via MHC class I

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. [GOC:add]


regulation of antigen processing and presentation via MHC class Ib

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. [GOC:add]


down-regulation of antigen processing and presentation via MHC class Ib

downregulation of antigen processing and presentation via MHC class Ib

down regulation of antigen processing and presentation via MHC class Ib

negative regulation of antigen processing and presentation via MHC class Ib

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. [GOC:add]


upregulation of antigen processing and presentation via MHC class Ib

up-regulation of antigen processing and presentation via MHC class Ib

up regulation of antigen processing and presentation via MHC class Ib

positive regulation of antigen processing and presentation via MHC class Ib

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. [GOC:add]


regulation of peptide antigen processing and presentation via MHC class Ib

regulation of antigen processing and presentation of peptide antigen via MHC class Ib

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. [GOC:add]


downregulation of antigen processing and presentation of peptide antigen via MHC class Ib

down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib

negative regulation of peptide antigen processing and presentation via MHC class Ib

down regulation of antigen processing and presentation of peptide antigen via MHC class Ib

negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. [GOC:add]


up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib

up regulation of antigen processing and presentation of peptide antigen via MHC class Ib

upregulation of antigen processing and presentation of peptide antigen via MHC class Ib

positive regulation of peptide antigen processing and presentation via MHC class Ib

positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. [GOC:add]


regulation of lipid antigen processing and presentation via MHC class Ib

regulation of antigen processing and presentation of lipid antigen via MHC class Ib

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. [GOC:add]


downregulation of antigen processing and presentation of lipid antigen via MHC class Ib

down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib

down regulation of antigen processing and presentation of lipid antigen via MHC class Ib

negative regulation of lipid antigen processing and presentation via MHC class Ib

negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. [GOC:add]


upregulation of antigen processing and presentation of lipid antigen via MHC class Ib

up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib

positive regulation of lipid antigen processing and presentation via MHC class Ib

up regulation of antigen processing and presentation of lipid antigen via MHC class Ib

positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. [GOC:add]


regulation of polysaccharide antigen processing and presentation via MHC class II

regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. [GOC:add]


down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II

negative regulation of polysaccharide antigen processing and presentation via MHC class II

down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. [GOC:add]


positive regulation of polysaccharide antigen processing and presentation via MHC class II

upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II

up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. [GOC:add]


regulation of dendritic cell antigen processing and presentation

Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]


downregulation of dendritic cell antigen processing and presentation

down-regulation of dendritic cell antigen processing and presentation

down regulation of dendritic cell antigen processing and presentation

negative regulation of dendritic cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]


up regulation of dendritic cell antigen processing and presentation

up-regulation of dendritic cell antigen processing and presentation

upregulation of dendritic cell antigen processing and presentation

positive regulation of dendritic cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]


regulation of myeloid dendritic cell antigen processing and presentation

Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. [GOC:add]


down-regulation of myeloid dendritic cell antigen processing and presentation

downregulation of myeloid dendritic cell antigen processing and presentation

down regulation of myeloid dendritic cell antigen processing and presentation

negative regulation of myeloid dendritic cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. [GOC:add]


upregulation of myeloid dendritic cell antigen processing and presentation

up regulation of myeloid dendritic cell antigen processing and presentation

up-regulation of myeloid dendritic cell antigen processing and presentation

positive regulation of myeloid dendritic cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. [GOC:add]


regulation of plasmacytoid dendritic cell antigen processing and presentation

Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. [GOC:add]


down-regulation of plasmacytoid dendritic cell antigen processing and presentation

downregulation of plasmacytoid dendritic cell antigen processing and presentation

down regulation of plasmacytoid dendritic cell antigen processing and presentation

negative regulation of plasmacytoid dendritic cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. [GOC:add]


up-regulation of plasmacytoid dendritic cell antigen processing and presentation

upregulation of plasmacytoid dendritic cell antigen processing and presentation

up regulation of plasmacytoid dendritic cell antigen processing and presentation

positive regulation of plasmacytoid dendritic cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. [GOC:add]


regulation of monocyte antigen processing and presentation

Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. [GOC:add]


down-regulation of monocyte antigen processing and presentation

downregulation of monocyte antigen processing and presentation

down regulation of monocyte antigen processing and presentation

negative regulation of monocyte antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. [GOC:add]


up-regulation of monocyte antigen processing and presentation

up regulation of monocyte antigen processing and presentation

upregulation of monocyte antigen processing and presentation

positive regulation of monocyte antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. [GOC:add]


regulation of macrophage antigen processing and presentation

Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. [GOC:add]


down regulation of macrophage antigen processing and presentation

down-regulation of macrophage antigen processing and presentation

downregulation of macrophage antigen processing and presentation

negative regulation of macrophage antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. [GOC:add]


up regulation of macrophage antigen processing and presentation

up-regulation of macrophage antigen processing and presentation

upregulation of macrophage antigen processing and presentation

positive regulation of macrophage antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. [GOC:add]


regulation of non-professional antigen presenting cell antigen processing and presentation

Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. [GOC:add]


down regulation of non-professional antigen presenting cell antigen processing and presentation

down-regulation of non-professional antigen presenting cell antigen processing and presentation

downregulation of non-professional antigen presenting cell antigen processing and presentation

negative regulation of non-professional antigen presenting cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. [GOC:add]


up-regulation of non-professional antigen presenting cell antigen processing and presentation

up regulation of non-professional antigen presenting cell antigen processing and presentation

upregulation of non-professional antigen presenting cell antigen processing and presentation

positive regulation of non-professional antigen presenting cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. [GOC:add]


regulation of B lymphocyte antigen processing and presentation

regulation of B-cell antigen processing and presentation

regulation of B-lymphocyte antigen processing and presentation

regulation of B cell antigen processing and presentation

Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation. [GOC:add]


negative regulation of B lymphocyte antigen processing and presentation

down-regulation of B cell antigen processing and presentation

down regulation of B cell antigen processing and presentation

downregulation of B cell antigen processing and presentation

negative regulation of B-cell antigen processing and presentation

negative regulation of B-lymphocyte antigen processing and presentation

negative regulation of B cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation. [GOC:add]


positive regulation of B lymphocyte antigen processing and presentation

upregulation of B cell antigen processing and presentation

up-regulation of B cell antigen processing and presentation

positive regulation of B-cell antigen processing and presentation

positive regulation of B-lymphocyte antigen processing and presentation

up regulation of B cell antigen processing and presentation

positive regulation of B cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation. [GOC:add]


regulation of T-lymphocyte antigen processing and presentation

regulation of T lymphocyte antigen processing and presentation

regulation of T-cell antigen processing and presentation

regulation of T cell antigen processing and presentation

Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. [GOC:add]


negative regulation of T lymphocyte antigen processing and presentation

down regulation of T cell antigen processing and presentation

down-regulation of T cell antigen processing and presentation

negative regulation of T-cell antigen processing and presentation

negative regulation of T-lymphocyte antigen processing and presentation

downregulation of T cell antigen processing and presentation

negative regulation of T cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. [GOC:add]


up-regulation of T cell antigen processing and presentation

up regulation of T cell antigen processing and presentation

positive regulation of T lymphocyte antigen processing and presentation

positive regulation of T-cell antigen processing and presentation

positive regulation of T-lymphocyte antigen processing and presentation

upregulation of T cell antigen processing and presentation

positive regulation of T cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. [GOC:add]


regulation of proteolysis associated with antigen processing and presentation

Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. [GOC:add]


down-regulation of proteolysis associated with antigen processing and presentation

downregulation of proteolysis associated with antigen processing and presentation

down regulation of proteolysis associated with antigen processing and presentation

negative regulation of proteolysis associated with antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. [GOC:add]


up regulation of proteolysis associated with antigen processing and presentation

upregulation of proteolysis associated with antigen processing and presentation

up-regulation of proteolysis associated with antigen processing and presentation

positive regulation of proteolysis associated with antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. [GOC:add]


Any process that modulates the frequency, rate, or extent of granuloma formation. [GOC:add]


down-regulation of granuloma formation
down regulation of granuloma formation
downregulation of granuloma formation

negative regulation of granuloma formation

Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation. [GOC:add]


up-regulation of granuloma formation
upregulation of granuloma formation
up regulation of granuloma formation

positive regulation of granuloma formation

Any process that activates or increases the frequency, rate, or extent of granuloma formation. [GOC:add]


Any process that modulates the frequency, rate, or extent of germinal center formation. [GOC:add]


down regulation of germinal center formation

downregulation of germinal center formation

down-regulation of germinal center formation

negative regulation of germinal center formation

Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation. [GOC:add]


up-regulation of germinal center formation

upregulation of germinal center formation

up regulation of germinal center formation

positive regulation of germinal center formation

Any process that activates or increases the frequency, rate, or extent of germinal center formation. [GOC:add]


Any process that modulates the frequency, rate, or extent of immunoglobulin production. [GOC:add]


downregulation of immunoglobulin production

down regulation of immunoglobulin production

down-regulation of immunoglobulin production

negative regulation of immunoglobulin production

Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. [GOC:add]


up regulation of immunoglobulin production

upregulation of immunoglobulin production

up-regulation of immunoglobulin production

positive regulation of immunoglobulin production

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. [GOC:add]


Any process that modulates the frequency, rate, or extent of tolerance induction. [GOC:add]


downregulation of tolerance induction
down regulation of tolerance induction
down-regulation of tolerance induction

negative regulation of tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction. [GOC:add]


upregulation of tolerance induction
up regulation of tolerance induction
up-regulation of tolerance induction

positive regulation of tolerance induction

Any process that activates or increases the frequency, rate, or extent of tolerance induction. [GOC:add]


regulation of central tolerance induction

Any process that modulates the frequency, rate, or extent of central tolerance induction. [GOC:add]


down regulation of central tolerance induction

downregulation of central tolerance induction

down-regulation of central tolerance induction

negative regulation of central tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction. [GOC:add]


upregulation of central tolerance induction

up regulation of central tolerance induction

up-regulation of central tolerance induction

positive regulation of central tolerance induction

Any process that activates or increases the frequency, rate, or extent of central tolerance induction. [GOC:add]


regulation of tolerance induction to self antigen

Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen. [GOC:add]


downregulation of tolerance induction to self antigen

down-regulation of tolerance induction to self antigen

down regulation of tolerance induction to self antigen

negative regulation of tolerance induction to self antigen

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen. [GOC:add]


up-regulation of tolerance induction to self antigen

upregulation of tolerance induction to self antigen

up regulation of tolerance induction to self antigen

positive regulation of tolerance induction to self antigen

Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen. [GOC:add]


regulation of immune response-dependent tolerance induction

regulation of tolerance induction dependent upon immune response

Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response. [GOC:add]


downregulation of tolerance induction dependent upon immune response

negative regulation of immune response-dependent tolerance induction

down regulation of tolerance induction dependent upon immune response

down-regulation of tolerance induction dependent upon immune response

negative regulation of tolerance induction dependent upon immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response. [GOC:add]


up-regulation of tolerance induction dependent upon immune response

up regulation of tolerance induction dependent upon immune response

positive regulation of immune response-dependent tolerance induction

upregulation of tolerance induction dependent upon immune response

positive regulation of tolerance induction dependent upon immune response

Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response. [GOC:add]


regulation of tolerance induction to nonself antigen

Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen. [GOC:add]


down regulation of tolerance induction to nonself antigen

down-regulation of tolerance induction to nonself antigen

downregulation of tolerance induction to nonself antigen

negative regulation of tolerance induction to nonself antigen

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen. [GOC:add]


upregulation of tolerance induction to nonself antigen

up-regulation of tolerance induction to nonself antigen

up regulation of tolerance induction to nonself antigen

positive regulation of tolerance induction to nonself antigen

Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen. [GOC:add]


regulation of peripheral tolerance induction

Any process that modulates the frequency, rate, or extent of peripheral tolerance induction. [GOC:add]


down-regulation of peripheral tolerance induction

downregulation of peripheral tolerance induction

down regulation of peripheral tolerance induction

negative regulation of peripheral tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction. [GOC:add]


up-regulation of peripheral tolerance induction

upregulation of peripheral tolerance induction

up regulation of peripheral tolerance induction

positive regulation of peripheral tolerance induction

Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction. [GOC:add]


regulation of B-lymphocyte tolerance induction

regulation of B lymphocyte tolerance induction

regulation of B-cell tolerance induction

regulation of B cell tolerance induction

Any process that modulates the frequency, rate, or extent of B cell tolerance induction. [GOC:add]


negative regulation of B-lymphocyte tolerance induction

down-regulation of B cell tolerance induction

negative regulation of B-cell tolerance induction

negative regulation of B lymphocyte tolerance induction

downregulation of B cell tolerance induction

down regulation of B cell tolerance induction

negative regulation of B cell tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction. [GOC:add]


up regulation of B cell tolerance induction

up-regulation of B cell tolerance induction

upregulation of B cell tolerance induction

positive regulation of B-cell tolerance induction

positive regulation of B lymphocyte tolerance induction

positive regulation of B-lymphocyte tolerance induction

positive regulation of B cell tolerance induction

Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction. [GOC:add]


regulation of T-lymphocyte tolerance induction

regulation of T-cell tolerance induction

regulation of T lymphocyte tolerance induction

regulation of T cell tolerance induction

Any process that modulates the frequency, rate, or extent of T cell tolerance induction. [GOC:add]


down regulation of T cell tolerance induction

negative regulation of T lymphocyte tolerance induction

negative regulation of T-lymphocyte tolerance induction

negative regulation of T-cell tolerance induction

down-regulation of T cell tolerance induction

downregulation of T cell tolerance induction

negative regulation of T cell tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction. [GOC:add]


up-regulation of T cell tolerance induction

up regulation of T cell tolerance induction

positive regulation of T-cell tolerance induction

positive regulation of T-lymphocyte tolerance induction

upregulation of T cell tolerance induction

positive regulation of T lymphocyte tolerance induction

positive regulation of T cell tolerance induction

Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction. [GOC:add]


regulation of T lymphocyte anergy
regulation of T-cell anergy
regulation of T-lymphocyte anergy

Any process that modulates the frequency, rate, or extent of T cell anergy. [GOC:add]


negative regulation of T-lymphocyte anergy

negative regulation of T lymphocyte anergy

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy. [GOC:add]


positive regulation of T-lymphocyte anergy

positive regulation of T lymphocyte anergy

Any process that activates or increases the frequency, rate, or extent of T cell anergy. [GOC:add]


regulation of B-cell anergy
regulation of B-lymphocyte anergy
regulation of B lymphocyte anergy

Any process that modulates the frequency, rate, or extent of B cell anergy. [GOC:add]


negative regulation of B-lymphocyte anergy

negative regulation of B lymphocyte anergy

Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy. [GOC:add]


positive regulation of B lymphocyte anergy

positive regulation of B-lymphocyte anergy

Any process that activates or increases the frequency, rate, or extent of B cell anergy. [GOC:add]


regulation of acute inflammatory response

Any process that modulates the frequency, rate, or extent of an acute inflammatory response. [GOC:add]


down-regulation of acute inflammatory response

down regulation of acute inflammatory response

downregulation of acute inflammatory response

negative regulation of acute inflammatory response

Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. [GOC:add]


upregulation of acute inflammatory response

up regulation of acute inflammatory response

up-regulation of acute inflammatory response

positive regulation of acute inflammatory response

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]


regulation of chronic inflammatory response

Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]


down-regulation of chronic inflammatory response

down regulation of chronic inflammatory response

downregulation of chronic inflammatory response

negative regulation of chronic inflammatory response

Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]


upregulation of chronic inflammatory response

up regulation of chronic inflammatory response

up-regulation of chronic inflammatory response

positive regulation of chronic inflammatory response

Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]


pro-T cell fate commitment
pro-T lymphocyte lineage commitment
pro-T lymphocyte fate commitment

The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell. [GOC:add, ISBN:0781735149]


somatic recombination of TCR gene segments

somatic recombination of T cell receptor gene segments

The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments. [GOC:add, ISBN:0781735149]


Any process that modulates the frequency, rate, or extent of an immune system process. [GOC:add]


down regulation of immune system process

down-regulation of immune system process

negative regulation of immune system process

Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. [GOC:add]


up regulation of immune system process
upregulation of immune system process
up-regulation of immune system process

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process. [GOC:add]


regulation of leucocyte migration
regulation of immune cell migration

Any process that modulates the frequency, rate, or extent of leukocyte migration. [GOC:add]


negative regulation of leucocyte migration

negative regulation of immune cell migration

negative regulation of leukocyte migration

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. [GOC:add]


positive regulation of immune cell migration

positive regulation of leucocyte migration

positive regulation of leukocyte migration

Any process that activates or increases the frequency, rate, or extent of leukocyte migration. [GOC:add]


regulation of immune cell chemotaxis
regulation of leucocyte chemotaxis

Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]


negative regulation of immune cell chemotaxis

negative regulation of leucocyte chemotaxis

negative regulation of leukocyte chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]


positive regulation of leucocyte chemotaxis

positive regulation of immune cell chemotaxis

positive regulation of leukocyte chemotaxis

Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]


Any process that modulates the frequency, rate, or extent of cellular extravasation. [GOC:add]


downregulation of cellular extravasation

down regulation of cellular extravasation

down-regulation of cellular extravasation

negative regulation of cellular extravasation

Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation. [GOC:add]


up regulation of cellular extravasation
upregulation of cellular extravasation
up-regulation of cellular extravasation

positive regulation of cellular extravasation

Any process that activates or increases the frequency, rate, or extent of cellular extravasation. [GOC:add]


regulation of leucocyte activation
regulation of immune cell activation

Any process that modulates the frequency, rate, or extent of leukocyte activation. [GOC:add]


positive regulation of leucocyte activation

positive regulation of immune cell activation

positive regulation of leukocyte activation

Any process that activates or increases the frequency, rate, or extent of leukocyte activation. [GOC:add]


Any process that modulates the frequency, rate, or extent of an immune effector process. [GOC:add]


down regulation of immune effector process

downregulation of immune effector process

down-regulation of immune effector process

negative regulation of immune effector process

Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. [GOC:add]


up regulation of immune effector process

up-regulation of immune effector process

positive regulation of immune effector process

Any process that activates or increases the frequency, rate, or extent of an immune effector process. [GOC:add]


regulation of production of molecular mediator of immune response

Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]


downregulation of production of molecular mediator of immune response

down-regulation of production of molecular mediator of immune response

down regulation of production of molecular mediator of immune response

negative regulation of production of molecular mediator of immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]


up regulation of production of molecular mediator of immune response

upregulation of production of molecular mediator of immune response

up-regulation of production of molecular mediator of immune response

positive regulation of production of molecular mediator of immune response

Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]


regulation of immune cell mediated immunity

regulation of leucocyte mediated immunity

regulation of leukocyte mediated immunity

Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]


down-regulation of leukocyte mediated immunity

downregulation of leukocyte mediated immunity

down regulation of leukocyte mediated immunity

negative regulation of leucocyte mediated immunity

negative regulation of immune cell mediated immunity

negative regulation of leukocyte mediated immunity

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]


positive regulation of leucocyte mediated immunity

up regulation of leukocyte mediated immunity

positive regulation of immune cell mediated immunity

upregulation of leukocyte mediated immunity

up-regulation of leukocyte mediated immunity

positive regulation of leukocyte mediated immunity

Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]


regulation of lymphocyte mediated immunity

Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]


downregulation of lymphocyte mediated immunity

down regulation of lymphocyte mediated immunity

down-regulation of lymphocyte mediated immunity

negative regulation of lymphocyte mediated immunity

Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]


up-regulation of lymphocyte mediated immunity

upregulation of lymphocyte mediated immunity

up regulation of lymphocyte mediated immunity

positive regulation of lymphocyte mediated immunity

Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]


regulation of T-lymphocyte mediated immunity

regulation of T lymphocyte mediated immunity

Any process that modulates the frequency, rate, or extent of T cell mediated immunity. [GOC:add]


negative regulation of T-cell mediated immunity

down regulation of T cell mediated immunity

down-regulation of T cell mediated immunity

downregulation of T cell mediated immunity

negative regulation of T-lymphocyte mediated immunity

negative regulation of T lymphocyte mediated immunity

negative regulation of T cell mediated immunity

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. [GOC:add]


positive regulation of T-lymphocyte mediated immunity

up regulation of T cell mediated immunity

upregulation of T cell mediated immunity

positive regulation of T-cell mediated immunity

positive regulation of T lymphocyte mediated immunity

up-regulation of T cell mediated immunity

positive regulation of T cell mediated immunity

Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. [GOC:add]


A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. [GOC:dos, GOC:go_curators, PMID:19028679, PMID:20054389, PMID:6305978]


A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV. [Wikipedia:Myosin]


A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region. [Wikipedia:Myosin]


A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing one or more class X myosin heavy chains and associated light chains. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing one or more class XIII myosin heavy chains and associated light chains. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886]


A myosin complex containing one or more class XVII myosin heavy chains and associated light chains. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain. [PMID:11294886]


A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division. [GOC:jl]


EP1 subtype prostaglandin E2 receptor ligand


EP2 subtype prostaglandin E2 receptor ligand


EP3 subtype prostaglandin E2 receptor ligand


EP4 subtype prostaglandin E2 receptor ligand


regulation of glucocorticoid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. [GOC:mah]


down regulation of glucocorticoid biosynthetic process

down-regulation of glucocorticoid biosynthetic process

downregulation of glucocorticoid biosynthetic process

negative regulation of glucocorticoid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. [GOC:mah]


up regulation of glucocorticoid biosynthetic process

upregulation of glucocorticoid biosynthetic process

up-regulation of glucocorticoid biosynthetic process

positive regulation of glucocorticoid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. [GOC:mah]


regulation of glucocorticoid catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. [GOC:mah]


down-regulation of glucocorticoid catabolic process

down regulation of glucocorticoid catabolic process

downregulation of glucocorticoid catabolic process

negative regulation of glucocorticoid catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. [GOC:mah]


upregulation of glucocorticoid catabolic process

up regulation of glucocorticoid catabolic process

up-regulation of glucocorticoid catabolic process

positive regulation of glucocorticoid catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. [GOC:mah]


regulation of target of rapamycin signaling pathway

regulation of target of rapamycin signalling pathway

Any process that modulates the frequency, rate or extent of TOR signaling. [GOC:mah]


negative regulation of TOR signaling pathway

negative regulation of target of rapamycin signaling pathway

negative regulation of target of rapamycin signalling pathway

negative regulation of TOR signalling pathway

down-regulation of TOR signaling pathway

negative regulation of TOR signaling cascade

down regulation of TOR signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. [GOC:mah]


A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis. [GOC:mah, PMID:12388753]


The series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state. [GOC:mah]


regulation of ARF protein signal transduction

Any process that modulates the frequency, rate or extent of ARF protein signal transduction. [GOC:mah]


downregulation of ARF protein signal transduction

down-regulation of ARF protein signal transduction

down regulation of ARF protein signal transduction

negative regulation of ARF protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction. [GOC:mah]


upregulation of ARF protein signal transduction

up regulation of ARF protein signal transduction

up-regulation of ARF protein signal transduction

positive regulation of ARF protein signal transduction

Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction. [GOC:mah]


regulation of Ran protein signal transduction

Any process that modulates the frequency, rate or extent of Ran protein signal transduction. [GOC:mah]


downregulation of Ran protein signal transduction

down-regulation of Ran protein signal transduction

down regulation of Ran protein signal transduction

negative regulation of Ran protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction. [GOC:mah]


upregulation of Ran protein signal transduction

up-regulation of Ran protein signal transduction

up regulation of Ran protein signal transduction

positive regulation of Ran protein signal transduction

Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction. [GOC:mah]


2-methylbutanal reductase (NADP) activity

2-methylbutyraldehyde reductase (NADP) activity

Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+. [GOC:mah, PMID:12210903]


The covalent addition to a protein of ISG15, a ubiquitin-like protein. [GOC:mah]


negative elongation factor complex location

A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing. [PMID:12612062]


The proteolytic processing of trypsinogen to the active form, trypsin. [GOC:mah]


up-regulation of insulin secretion
upregulation of insulin secretion
up regulation of insulin secretion

positive regulation of insulin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. [GOC:mah]


Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]


Binding to a light chain of a myosin complex. [GOC:mah]


Binding to the head/neck region of a myosin heavy chain. [GOC:mah]


Binding to the tail region of a myosin heavy chain. [GOC:mah]


Binding to a light chain of a myosin I complex. [GOC:mah]


Binding to the head/neck region of a myosin I heavy chain. [GOC:mah]


Binding to the tail region of a myosin I heavy chain. [GOC:mah]


Binding to a light chain of a myosin II complex. [GOC:mah]


Binding to the head/neck region of a myosin II heavy chain. [GOC:mah]


Binding to the tail region of a myosin II heavy chain. [GOC:mah]


Binding to a heavy chain of a myosin complex. [GOC:mah]


Binding to a heavy chain of a myosin I complex. [GOC:mah]


Binding to a heavy chain of a myosin II complex. [GOC:mah]


A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. [PMID:16239144]


A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]


NAD-dependent histone deacetylase activity (H3-K14 specific)

Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. [PMID:28450737]


mtDNA metabolic process
mtDNA metabolism
mitochondrial DNA metabolism

The chemical reactions and pathways involving mitochondrial DNA. [GOC:mah]


mitochondrial DNA breakdown
mitochondrial DNA catabolism
mtDNA catabolism
mitochondrial DNA degradation
mtDNA degradation
mtDNA catabolic process
mtDNA breakdown

The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA. [GOC:mah]


DRB sensitivity inducing factor complex location

5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex location

A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865]


guanyl-nucleotide exchange factor complex location

A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. [GOC:mah]


A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole. [PMID:15563611]


A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria. [GOC:giardia, PMID:10361303, PMID:14614504, PMID:24316280]


The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. [GOC:mah]


The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. [GOC:mah]


Binding to a clathrin heavy chain. [GOC:mah]


Binding to a clathrin light chain. [GOC:mah]


Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph]


down regulation of translation in response to stress

downregulation of translation in response to stress

down-regulation of translation in response to stress

negative regulation of translation in response to stress

Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress. [GOC:mah]


upregulation of translation in response to stress

up-regulation of translation in response to stress

up regulation of translation in response to stress

positive regulation of translation in response to stress

Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. [GOC:mah]


down-regulation of translation in response to osmotic stress

downregulation of translation in response to osmotic stress

down regulation of translation in response to osmotic stress

negative regulation of translation in response to osmotic stress

Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]


up-regulation of translation in response to osmotic stress

up regulation of translation in response to osmotic stress

upregulation of translation in response to osmotic stress

positive regulation of translation in response to osmotic stress

Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]


maintenance of protein location in cell cortex

A process in which a protein or protein complex is maintained in a specific location in the cell cortex. [GOC:vw]