Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule. [PMID:11733745]


Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]


Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]


Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]


Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]


Binding to an unprocessed ribosomal RNA transcript. [GOC:jl]


Binding to single-stranded RNA. [GOC:jl]


Binding to a sequence of cytosine residues in an RNA molecule. [GOC:mah]


Binding to a sequence of uracil residues in an RNA molecule. [GOC:mah]


Binding to a small nucleolar RNA. [GOC:mah]


Binding to a small nuclear RNA (snRNA). [GOC:mah]


Binding to a U1 small nuclear RNA (U1 snRNA). [GOC:mah]


Binding to a U11 small nuclear RNA (U11 snRNA). [GOC:jl]


Binding to a U12 small nuclear RNA (U12 snRNA). [GOC:jl]


Binding to a U2 small nuclear RNA (U2 snRNA). [GOC:jl]


Binding to a U4 small nuclear RNA (U4 snRNA). [GOC:jl]


Binding to a U4atac small nuclear RNA (U4atac snRNA). [GOC:jl]


Binding to a U5 small nuclear RNA (U5 snRNA). [GOC:jl]


Binding to a U6 small nuclear RNA (U6 snRNA). [GOC:mah]


Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end. [GOC:mah]


Binding to a U6atac small nuclear RNA (U6atac snRNA). [GOC:jl]


translation factor activity, RNA binding

Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. [GOC:ai, GOC:vw]


OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs. [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN]


protein-synthesizing GTPase activity, elongation

OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.48]


protein-synthesizing GTPase activity, initiation


protein-synthesizing GTPase activity, termination


Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai]


Functions in chain elongation during polypeptide synthesis at the ribosome. [ISBN:0198506732]


Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732]


translation repressor activity, nucleic acid binding


Functions in the termination of translation. [GOC:ma]


Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. [ISBN:0198547684]


translation release factor activity, codon nonspecific

A translation release factor that is not specific to particular codons; binds to guanine nucleotides. [ISBN:0198547684]


translation release factor activity, codon specific

A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. [ISBN:0198547684]


Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. [GOC:mah, ISBN:0198547684]


Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:ai]


adenosine 3',5'-cyclophosphate binding
cyclic AMP binding
3',5' cAMP binding
3',5'-cAMP binding

Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]


3',5'-cGMP binding
3',5' cGMP binding
cyclic GMP binding

Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). [GOC:ai]


Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. [GOC:ai]


Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate. [ISBN:0198506732]


Binding to AMP, adenosine monophosphate. [GOC:go_curators]


Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]


2'-5' oligoadenylate synthetase activity

Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. [ISBN:0198506732]


ATP phosphohydrolase activity
adenosine triphosphatase activity
ATP hydrolase activity
ATP hydrolysis activity
adenosinetriphosphatase activity

Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]


single-stranded DNA-dependent ATP-dependent DNA helicase activity

single-stranded DNA-dependent ATPase activity

ssDNA-dependent ATP-dependent DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. [GOC:jl]


Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. [GOC:pdt]


Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. [GOC:jl]


arsenite-transmembrane transporting ATPase activity

ATPase-coupled arsenite transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). [PMID:10970874, RHEA:11348]


ATP-dependent beta-glucan transporter activity

ATPase-coupled beta-glucan transporter activity


ATPase-coupled capsular-polysaccharide transporter activity

ATP-dependent capsular-polysaccharide transporter activity

ABC-type capsular-polysaccharide transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out). [EC:7.6.2.12]


ATP-dependent heme transmembrane transporter activity

ATPase-coupled heme transmembrane transporter activity

Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out). [RHEA:19261]


ATP-dependent intramembrane lipopolysaccharide transporter activity

lipopolysaccharide floppase activity (cytosolic to exoplasmic leaftlet)

Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [EC:7.5.2.5]


ATP-dependent peptide transmembrane transporter activity

ATPase-coupled peptide transmembrane transporter activity


ATPase-coupled teichoic acid transmembrane transporter activity

ATP-dependent teichoic acid transmembrane transporter activity

ABC-type teichoic acid transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out). [PMID:7565096]


ATPase-coupled glutathione S-conjugate transmembrane transporter activity

glutathione S-conjugate-exporting ATPase activity

ABC-type glutathione S-conjugate transporter activity

Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out). [GOC:jl, PMID:1455517, RHEA:19121]

ATP-dependent glutathione S-conjugate export pump


OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate. [GOC:ai]


ATP-dependent cadmium transmembrane transporter activity

ATPase-coupled cadmium transmembrane transporter activity


OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]


ATPase-coupled peptide antigen transmembrane transporter activity

peptide antigen-transporting ATPase activity

major histocompatibility peptide transporter activity

ATP-dependent peptide antigen transmembrane transporter activity

ABC-type peptide antigen transporter activity

Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate. [TC:3.A.1.209.1]


OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating. [GOC:jl]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


thiamin pyrophosphate transporting ATPase activity

thiamine pyrophosphate-transporting ATPase activity


transmembrane conductance regulator activity

OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]


intracellularly ATP-gated chloride channel activity

Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. [PMID:24727426, PMID:9922375]


ABC-type xenobiotic transporter activity

ATPase-coupled xenobiotic transmembrane transporter activity

ATP-dependent xenobiotic transmembrane transporter activity

xenobiotic transmembrane transporting ATPase activity

Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). [EC:7.6.2.2]


ATP-dependent amino acid transmembrane transporter activity

ATPase-coupled amino acid transmembrane transporter activity

ABC-type amino acid transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). [GOC:ai, GOC:mah]


nonpolar amino acid-transporting ATPase activity

nonpolar-amino acid-transporting ATPase activity

ATP-dependent nonpolar-amino acid transporter activity

ATPase-coupled nonpolar-amino acid transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). [EC:7.4.2.2]


OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). [EC:3.6.3.22, TC:3.A.1.4.1]


polar-amino acid-importing ATPase activity

polar amino acid-importing ATPase activity

ATP-dependent polar amino acid-transporter activity

polar-amino acid-transporting ATPase activity

polar amino acid uptake transporter activity

ATPase-coupled polar amino acid-transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:7.4.2.1]


ATPase-coupled L-arginine transmembrane transporter activity


OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:3.6.3.21, TC:3.A.1.3.10]


OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:3.6.3.21, TC:3.A.1.3.4]


OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:3.6.3.21, TC:3.A.1.3.1]


carbohydrate-importing ABC transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in). [GOC:ai]

carbohydrate uptake transporter activity


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in). [GOC:curators]


galactose/glucose (methylgalactoside) porter activity


glycerol phosphate-importing ATPase activity


ATP-dependent cation transmembrane transporter activity

ATPase-coupled cation transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:ai]


plasma membrane cation-transporting ATPase


ATPase-coupled ferric-enterobactin transmembrane transporter activity

ATP-dependent ferric-enterobactin transmembrane transporter activity

ABC-type ferric-enterobactin transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in). [RHEA:58492]


ATP-dependent ferric-hydroxamate transmembrane transporter activity

ATPase-coupled ferric-hydroxamate transmembrane transporter activity

ABC-type ferric hydroxamate transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in). [PMID:1551849]


ATPase-coupled ferric iron transmembrane transporter activity

ABC-type ferric iron transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in). [RHEA:12332]


ABC-type glycerol 3-phosphate transporter

ATPase-coupled glycerol-3-phosphate transmembrane transporter activity

ABC-type glycerol-3-phosphate transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in). [RHEA:21668]


ATP-dependent guanine transmembrane transporter activity

ATPase-coupled guanine transmembrane transporter activity


ATP-dependent manganese transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in). [RHEA:17365]


molybdate transmembrane-transporting ATPase activity

ATPase-coupled molybdate transmembrane transporter activity


ATP-dependent nickel transmembrane transporter activity

ATPase-coupled nickel transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). [RHEA:15557]


nitrate transmembrane-transporting ATPase activity

ATPase-coupled nitrate transmembrane transporter activity


ATPase-coupled oligopeptide transmembrane transporter activity

ATP-dependent oligopeptide transmembrane transporter activity

ABC-type oligopeptide transporter activity

Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in). [RHEA:37271]


ATP-dependent oligosaccharide transmembrane transporter activity

ATPase-coupled oligosaccharide transmembrane transporter activity


ATP-dependent maltose transmembrane transporter activity

ATPase-coupled maltose transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in). [RHEA:22132]


phosphate ion transmembrane-transporting ATPase activity

ATPase-coupled phosphate ion transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in). [EC:7.3.2.1]


ATP-dependent polyamine transmembrane transporter activity

ATPase-coupled polyamine transmembrane transporter activity


ATP-dependent quaternary-ammonium compound transmembrane transporting activity

quaternary amine uptake transporter activity

ATPase-coupled quaternary ammonium compound transmembrane transporting activity


OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in). [EC:3.6.3.32, TC:3.A.1.12.1]


sulfate transmembrane-transporting ATPase activity

ATPase-coupled sulfate transmembrane transporter activity


ATP-dependent taurine transporter activity

ATPase-coupled taurine transporter activity


ATP-dependent vitamin B12 transmembrane transporter activity

ATPase-coupled cobalamin transmembrane transporter activity

ATP-dependent cobalamin transmembrane transporter activity

ATPase-coupled vitamin B12 transmembrane transporter activity

vitamin B12-transporting ATPase activity

ABC-type vitamin B12 transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. [GOC:pz, RHEA:17873]


Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. [GOC:mah, PMID:16428451, PMID:17631491]


OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out). [TC:3.A.2.-.-]


sodium-translocating F-type ATPase activity

sodium-transporting two-sector ATPase activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism. [RHEA:58158]

sodium-transporting ATP synthase activity, rotational mechanism


sodium-translocating V-type ATPase activity

OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria. [TC:3.A.2.2.2]


ion transmembrane transporter activity, phosphorylative mechanism

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. [PMID:10322420, PMID:10600683]


cadmium transmembrane transporter activity, phosphorylative mechanism

cadmium-translocating P-type ATPase activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out). [PMID:17326661]


ATP-dependent calcium transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). [RHEA:18105]

calcium transmembrane transporter activity, phosphorylative mechanism


hydrogen:potassium exchanging ATPase activity

potassium:proton exchanging ATPase activity

P-type potassium:proton transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). [RHEA:22044]


magnesium transmembrane transporter activity, phosphorylative mechanism

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in). [RHEA:10260]


ATP-dependent potassium transmembrane transporter activity

potassium transmembrane transporter activity, phosphorylative mechanism

P-type potassium transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). [RHEA:16777]


silver transmembrane transporter activity, phosphorylative mechanism

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) -> ADP + phosphate + Ag+(out). [RHEA:14733]


P-type sodium:potassium-exchanging transporter activity

sodium:potassium exchanging ATPase activity

P-type sodium:potassium-exchanging ATPase activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). [EC:7.2.2.13]


zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity

OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+. [TC:3.A.3.6.2]


zinc-translocating P-type ATPase activity

zinc transmembrane transporter activity, phosphorylative mechanism

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out). [RHEA:20621]


ABC-type protein transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in). [GOC:jl]


ATPase-coupled chloroplast protein transporter activity

AAA chloroplast protein-transporting ATPase

chloroplast protein-transporting ATPase activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma. [EC:7.4.2.4]


ATPase-coupled mitochondrial protein transporter activity

mitochondrial protein-transporting ATPase activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex. [EC:7.4.2.3]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


ATPase-coupled protein transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins. [PMID:30346996]


Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate. [ISBN:0198506732]


Binding to GDP, guanosine 5'-diphosphate. [GOC:ai]


Binding to GMP, guanosine monophosphate. [GOC:ai]


Binding to GTP, guanosine triphosphate. [GOC:ai]


Catalysis of the reaction: GTP + H2O = GDP + phosphate. [ISBN:0198547684, PMID:26832457, PMID:27218782]


OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles. [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN]


heterotrimeric G-protein GTPase activity


OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis. [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN]


OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47]


OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47, PMID:12893813]


OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. [EC:3.6.1.47, GOC:mah, ISBN:0198547684]


OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others. [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN]


guanyl-nucleotide release factor activity

guanyl-nucleotide exchange factor activity

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]


Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate. [GOC:ai]


Binding to an odorant, any substance capable of stimulating the sense of smell. [GOC:jl, ISBN:0721662544]


Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. [GOC:ai]


cytochrome P450
cytochrome p450 activity

OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer. [ISBN:0198547684, PMID:1655423]


25-hydroxyvitamin D3 24-hydroxylase activity

Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol. [ISBN:0471331309]


Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. [GOC:mah]


arachidonic acid 14,15-epoxygenase activity

Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, RHEA:51472]


Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, PMID:18952572]


Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. [GOC:cb]


25-hydroxyvitamin D-1 alpha hydroxylase activity

25-hydroxy vitamin D3 1-alpha-hydroxylase activity

25-hydroxyvitamin D3 1alpha-hydroxylase activity

Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+). [EC:1.14.15.18, RHEA:20573]


Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. [EC:1.14.14.23]


Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. [Reactome:163103]


Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O. [EC:1.14.17.1, RHEA:19117]


Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide. [PMID:1742282, PMID:1981702]


olfactory-specific steroid hydroxylase activity


Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. [PMID:10882791]


Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+. [PMID:11429408, PMID:11891223]


Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). [EC:5.3.99.4, RHEA:23580]


Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. [PMID:19519282, PMID:9250660]


Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.4]


steroid 17-alpha-hydroxylase-C17-20 lyase activity

steroid 17alphahydroxylase/17,20 lyase activity

steroid 17-alpha-hydroxylase/17,20 lyase activity

Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. [EC:1.14.14.19]


Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O. [RHEA:65612]


Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. [GOC:mah]


Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O. [GOC:ai]


cytochrome P450 CYP2B10
cytochrome P450 CYP2D10
cytochrome P450 CYP2D11
cytochrome P450 CYP2B9


Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). [EC:5.3.99.5, RHEA:17137]


Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). [GOC:mah]


OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins. [GOC:ai, ISBN:0198506732]


OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans. [GOC:ai, ISBN:0198506732]


OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods. [GOC:ai, ISBN:0198506732]


Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:ai]


Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]


Combining with an extracellular or intracellular peptide to initiate a change in cell activity. [GOC:jl]


peptide receptor activity, G-protein coupled

peptide receptor activity, G protein coupled

G protein coupled peptide receptor activity

G-protein coupled peptide receptor activity

G protein-coupled peptide receptor activity

Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]


Combining with adrenomedullin to initiate a change in cell activity. [GOC:ai]


Combining with allatostatin to initiate a change in cell activity. [GOC:ai]


Combining with angiotensin to initiate a change in cell activity. [GOC:ai]


PLC-activating angiotensin receptor activity

An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. [GOC:mah, PMID:10977869]


An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. [GOC:mah, PMID:10977869]


Combining with bombesin to initiate a change in cell activity. [GOC:ai]


Combining with bradykinin to initiate a change in cell activity. [GOC:ai]


Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. [GOC:signaling, PMID:9835394]


Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. [GOC:ai, GOC:signaling]


Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265]


G-protein chemoattractant receptor activity

G protein chemoattractant receptor activity

G-protein coupled chemoattractant receptor activity

G protein-coupled chemoattractant receptor activity

Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah]


Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, GOC:signaling, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823, Wikipedia:Chemokine]


Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:signaling, PMID:8662823]


Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:signaling, PMID:8662823]


Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif. [GOC:dph, GOC:signaling]


Combining with galanin to initiate a change in cell activity. [GOC:ai]


Combining with melanocortin to initiate a change in cell activity. [GOC:ai]


adrenocorticotropic hormone receptor activity

Combining with corticotropin to initiate a change in cell activity. [GOC:ai]


Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin]


Combining with an N-formyl peptide to initiate a change in cell activity. [GOC:ai]


Combining with neuromedin U to initiate a change in cell activity. [GOC:ai]


Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai]


Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa. [GOC:bf, GOC:ma, PMID:21440021]


Combining with neuropeptide Y to initiate a change in cell activity. [PMID:9315606]


Combining with pancreatic polypeptide PP to initiate a change in cell activity. [PMID:9315606]

pancreatic polypeptide receptor activity


Combining with gut peptide YY to initiate a change in cell activity. [PMID:9315606]


Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]


Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]


substance K receptor activity
neuromedin L receptor activity

Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]


Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]


G-protein coupled neurotensin receptor activity

neurotensin receptor activity, G protein coupled

neurotensin receptor activity, G-protein coupled

G protein coupled neurotensin receptor activity

G protein-coupled neurotensin receptor activity

Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. [PMID:10390649]


OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands. [IUPHAR_RECEPTOR:317, PMID:10471416]


OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins. [IUPHAR_RECEPTOR:318]


OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. [IUPHAR_RECEPTOR:319]


OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors. [InterPro:IPR001420]


Combining with orexin to initiate a change in cell activity. [GOC:ai]


protease-activated receptor activity
proteinase activated receptor activity

A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. [GOC:mah, PMID:11356985, PMID:33742547]


growth hormone-inhibiting hormone receptor activity

Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). [GOC:ai, GOC:bf, Wikipedia:Somatostatin]

somatotrophin release inhibiting factor receptor activity


thrombin receptor activity, G-protein coupled

A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. [GOC:ai, GOC:pg, PMID:20423334]


Combining with urotensin II to initiate a change in cell activity. [GOC:mah, PMID:15102493]


Combining with oxytocin to initiate a change in cell activity. [GOC:ai]


Combining with vasopressin to initiate a change in cell activity. [GOC:ai]


Binding to a polyamine, an organic compound containing two or more amino groups. [GOC:ai]


Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. [GOC:ai]


Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]


Binding to catenin complex alpha subunit. [GOC:bf]


Binding to an amyloid-beta peptide/protein. [GOC:hjd]


Binding to a catenin beta subunit. [GOC:bf]


Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]


Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]


Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. [GOC:jl, GOC:mah, ISBN:0198506732]


Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732]


Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. [GOC:ai]


Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:ai, GOC:bf, ISBN:0198599471]


Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:ai, GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]


Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]


Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:ai]


Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]


granulocyte macrophage colony stimulating factor complex binding

granulocyte macrophage colony-stimulating factor complex binding

Binding to a granulocyte macrophage colony-stimulating factor complex. [GOC:ai]


Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. [PMID:9607096, Wikipedia:Interferon]


Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:9607096]


IFN-gamma receptor activity
type II interferon receptor activity
IFNG receptor activity

Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383]


IFNG binding
interferon-gamma binding
type II interferon binding

Binding to interferon-gamma. Interferon gamma is the only member of the type II interferon found so far. [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383]


Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. [GOC:jl]


interleukin-1, type I, activating binding

interleukin-1 activating receptor activity

interleukin-1, type I, activating receptor activity

Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. [PMID:15062641, PMID:18613828]


interleukin-1, type II, blocking binding

interleukin-1 blocking receptor activity

interleukin-1, type II, blocking receptor activity

Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors. [PMID:15062641, PMID:18613828]


IL-10 receptor activity
interleukin-10 receptor activity

Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


IL-11 receptor activity
gp130
interleukin-11 receptor activity

Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


interleukin-12 receptor activity
IL-12 receptor activity

Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


interleukin-15 receptor activity
IL-15 receptor activity

Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


interleukin-16 receptor activity
IL-16 receptor activity

Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:jl, GOC:signaling]


Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


IL-22 receptor activity
interleukin-22 receptor activity

Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


IL-23 receptor activity
interleukin-23 receptor activity

Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


IL-27 receptor activity
interleukin-27 receptor activity

Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


IL-4 receptor activity
interleukin-4 receptor activity

Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


interleukin-6 receptor activity
IL-6 receptor activity

Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


Binding to interleukin-1. [GOC:jl, ISBN:0198506732]


IL-12A binding
IL-12p35 binding
NKSFp35 binding
CLMFp35 binding

Binding to the alpha subunit of interleukin-12. [GOC:mah]


IL-12B binding
NKSFp40 binding
IL-12p40 binding
CLMFp40 binding

Binding to the beta subunit of interleukin-12. [GOC:mah]


Binding to a member of the interleukin-17 family of cytokines. [GOC:add, GOC:jl]


Binding to interleukin-24. [GOC:go_curators]


Binding to interleukin-25. [GOC:go_curators]


Binding to interleukin-26. [GOC:go_curators]


Binding to interleukin-27. [GOC:go_curators]


Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah]


Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]


OBSOLETE. Interacting selectively with two actin filaments to anchor them together. [GOC:jid]


Binding to an actin filament along its length. [GOC:mah]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Binding to monomeric actin, also known as G-actin. [GOC:ai]


OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]


barbed-end actin capping/severing activity


Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732]


OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane. [ISBN:0198599323]


Binding to a protein involved in modulating the reorganization of the cytoskeleton. [GOC:go_curators, PMID:15163540]


Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779]


Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. [GOC:mah]


Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments. [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. [GOC:mah, ISBN:0198506732]


Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. [GOC:curators, ISBN:0815316194]


Binding to troponin C, the calcium-binding subunit of the troponin complex. [GOC:mah, ISBN:0815316194]


Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]


ATP-dependent microtubule motor activity

A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. [PMID:19686686, PMID:32684327, PMID:32842864]


OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules. [GOC:hb]


ATP-dependent minus-end-directed microtubule motor activity

minus-end-directed ATP-dependent microtubule motor activity

kinesin ATP phosphohydrolase (minus-end-directed)

minus-end-directed kinesin ATPase activity

ATP-dependent microtubule motor activity, minus-end-directed

A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. [GOC:mah, GOC:vw, PMID:15659646, PMID:32842864]


ATP-dependent microtubule motor activity, plus-end-directed

plus-end-directed kinesin ATPase activity

plus-end-directed ATP-dependent microtubule motor activity

ATP-dependent plus-end-directed microtubule motor activity

kinesin ATP phosphohydrolase (plus-end-directed)

A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. [GOC:vw, PMID:32842864]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. [ISBN:0721662544]


Binding to a heavy chain of the dynein complex. [GOC:bf]


Binding to an intermediate chain of the dynein complex. [GOC:bf]


Binding to a light chain of the dynein complex. [GOC:bf]


Binding to an enzyme, a protein with catalytic activity. [GOC:jl]


Binding to an adenylate cyclase. [GOC:jl]


Binding to a DEAD/H-box RNA helicase. [GOC:jl]


Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]


Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]


Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. [GOC:jl]


Binding to a protein phosphatase 2B. [GOC:jl]


Binding to a protein phosphatase. [GOC:jl]


Binding to a protein phosphatase 1. [GOC:jl]


Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. [ISBN:0198506732]


Binding to catenin complex gamma subunit. [GOC:bf]


Growth Factor Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and often spatial complementarity with extracellular signaling molecules (ligands) involved in the control of target cell proliferation, survival, and differentiation.


fibroblast growth factor binding
FGF binding

Binding to a fibroblast growth factor. [PMID:9806903]


Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. [ISBN:0198506732]


Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:jl]


Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]


Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732]


Binding to an immunoglobulin of an IgA isotype. [GOC:add, ISBN:0781735149]


Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Binding to an immunoglobulin of the IgE isotype. [GOC:add, ISBN:0781735149]


Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Binding to an immunoglobulin of an IgG isotype. [GOC:add, ISBN:0781735149]


Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:2716741]


Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. [ISBN:0198506732]


Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. [GOC:jl, ISBN:0198506732]


OBSOLETE. Binding to a conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:jl, ISBN:0198506732]


Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]


high-density lipoprotein particle binding

Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. [GOC:mah]


low-density lipoprotein particle binding

Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. [GOC:mah]


low-density lipoprotein receptor activity

low-density lipoprotein particle receptor activity

Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis. [GOC:bf, ISBN:0198506732]


Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. [GOC:curators, GOC:pr, PMID:18923512]


nuclear localisation sequence binding
nuclear localization signal binding
NLS binding

Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. [GOC:ai]


Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome. [GOC:mah, ISBN:0879693568]


peroxisomal targeting signal 1 (PTS1) binding

peroxisome matrix targeting signal-1 binding

Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L. [GOC:mah, PMID:11687502]


peroxisomal targeting signal 2 (PTS2) binding

Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). [GOC:mah, PMID:11687502]

peroxisome matrix targeting signal-2 binding


Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein. [GOC:mah]


Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. [ISBN:0721662544]


carboxyl-terminus binding
COOH-terminus binding
carboxyl-terminal binding
carboxylate-terminus binding
C-terminal end binding
COOH-terminal binding
carboxy-terminal binding
carboxy-terminus binding
C-terminal binding

Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. [ISBN:0198506732]


Binding to a specific domain of a protein. [GOC:go_curators]


Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain. [GOC:go_curators]


Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. [GOC:go_curators, Pfam:PF00412]


Binding to a LRR domain (leucine rich repeats) of a protein. [GOC:go_curators, Pfam:PF00560]


Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]


Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. [GOC:go_curators, Pfam:PF00017]


Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]


Binding to a SMAD signaling protein. [GOC:ai]


Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. [PMID:12642621]


Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. [ISBN:0198506732]


Binding to a syntaxin-1 SNAP receptor. [GOC:ai]


Binding to a syntaxin-3 SNAP receptor. [GOC:ai]


Binding to a small nucleolar ribonucleoprotein particle. [GOC:mah]


Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. [GOC:go_curators, PMID:9355727]


Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. [GOC:go_curators, PMID:9082980]


Binding to a transcription factor, a protein required to initiate or regulate transcription. [ISBN:0198506732]


Binding to an aryl hydrocarbon receptor. [GOC:ai]


transcription cofactor activity
transcriptional co-regulator

A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]


A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]


3',5' cAMP response element binding protein binding

cyclic AMP response element binding protein binding

adenosine 3',5'-cyclophosphate response element binding protein binding

3',5'-cAMP response element binding protein binding

Binding to a cAMP response element binding protein (a CREB protein). [GOC:mah]


ligand-dependent nuclear receptor transcription coactivator activity

ligand-activated RNA polymerase II transcription factor binding transcription factor activity

ligand-dependent nuclear receptor transcription co-activator activity

transcription factor activity, ligand-activated RNA polymerase II transcription factor binding

A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:dph, GOC:tb]


A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]


Binding to a Wnt-protein, a secreted growth factor involved in signaling. [GOC:jl]


Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732]


Binding to a peripheral benzodiazepine receptor (PBR). [GOC:ceb, GOC:mah, PMID:9915832]


Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. [GOC:go_curators, ISBN:0198506732]


The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]


Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. [GOC:ai]


The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]


Binding to a gurken growth factor receptor. [GOC:ai]


fibroblast growth factor receptor binding

Binding to a fibroblast growth factor receptor (FGFR). [GOC:ceb]


FGFR antagonist activity
FGF receptor antagonist activity

fibroblast growth factor receptor antagonist activity

Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist. [GOC:mah]


Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. [GOC:ebc]

interleukin-1 receptor antagonist activity


interleukin-1 type I receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type I receptors. [GOC:ebc]


interleukin-1 type II receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type II receptors. [GOC:ebc]


type 1 fibroblast growth factor receptor binding

Binding to a type 1 fibroblast growth factor receptor (FGFR1). [GOC:ceb, GOC:fb_curators]


type 2 fibroblast growth factor receptor ligand


Binding to a ciliary neurotrophic factor receptor. [GOC:ai]

ciliary neurotrophic factor receptor binding


Binding to an erythropoietin receptor. [GOC:ai]


granulocyte macrophage colony-stimulating factor receptor binding

granulocyte macrophage colony stimulating factor receptor binding

granulocyte macrophage colony-stimulating factor receptor ligand

Binding to a granulocyte macrophage colony-stimulating factor receptor. [GOC:ai]


granulocyte colony stimulating factor receptor binding

granulocyte colony-stimulating factor receptor ligand

granulocyte colony-stimulating factor receptor binding

Binding to a granulocyte colony-stimulating factor receptor. [GOC:ai]


Binding to a growth hormone receptor. [GOC:ai]


interferon-gamma receptor ligand
interferon-gamma

Binding to an interferon-gamma receptor. [GOC:ai]


Binding to an interleukin-10 receptor. [GOC:ai]


Binding to an interleukin-15 receptor. [GOC:ai]


Binding to an interleukin-17 receptor. [GOC:ai]


Binding to an interleukin-17E receptor. [GOC:ai]


Binding to an interleukin-2 receptor. [GOC:ai]


Binding to an interleukin-21 receptor. [GOC:ai]


Binding to an interleukin-3 receptor. [GOC:ai]


Binding to an interleukin-4 receptor. [GOC:ai]


Binding to an interleukin-5 receptor. [GOC:ai]


Binding to an interleukin-6 receptor. [GOC:ai]


Binding to an interleukin-7 receptor. [GOC:ai]


Binding to an interleukin-9 receptor. [GOC:ai]


Binding to an leukemia inhibitory factor receptor. [GOC:ai]

leukemia inhibitory factor receptor binding


Binding to a prolactin receptor. [GOC:ai]


Binding to an hepatocyte growth factor receptor. [GOC:ai]

hepatocyte growth factor receptor binding


high molecular weight B cell growth factor receptor ligand


Binding to an interleukin-1 receptor. [GOC:go_curators]


Binding to an interleukin-16 receptor. [GOC:go_curators]


Binding to an interleukin-18 receptor. [GOC:go_curators]


Binding to an interleukin-19 receptor. [GOC:go_curators]


Binding to an interleukin-20 receptor. [GOC:go_curators]


Binding to an interleukin-22 receptor. [GOC:go_curators]


Binding to an interleukin-23 receptor. [GOC:go_curators]


Binding to an interleukin-25 receptor. [GOC:go_curators]


Binding to an interleukin-26 receptor. [GOC:go_curators]


Binding to an interleukin-8 receptor. [GOC:go_curators]


macrophage colony-stimulating factor receptor ligand


Binding to a neurotrophin receptor. [GOC:ai]


Binding to a nerve growth factor receptor. [GOC:ai, PMID:15654015]


Binding to a neurotrophin p75 receptor. [GOC:ai]


Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. [GOC:jl, PMID:10698217]


OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone. [ISBN:0198506732, ISBN:0721662544]


OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone. [ISBN:0198506732, ISBN:0721662544]


death receptor interacting protein activity

OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Binding to an apelin receptor. [GOC:mah, GOC:nln, GOC:vp, PMID:12787050]


Binding to a CCR chemokine receptor. [GOC:ai]


CXC chemokine receptor ligand
alpha chemokine receptor ligand


Binding to a CXCR1 chemokine receptor. [GOC:ceb, PMID:11910892]


Binding to a CXCR2 chemokine receptor. [GOC:ceb, PMID:11910892]


Binding to a frizzled (fz) receptor. [GOC:ceb]


Binding to a hypocretin receptor. [GOC:ceb, PMID:11988773]


The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]


The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. [GOC:dph, GOC:mah, ISBN:0198506732]


The action characteristic of a hormone that takes part in the digestion process. [GOC:ai]


alpha-melanophore stimulating hormone activity

alpha-melanocyte stimulating hormone activity


The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. [GOC:mah, InterPro:IPR003621, PMID:8618894]


follicle stimulating hormone activity
follitropin activity
FSH activity

The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. [ISBN:0198547684]


The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. [ISBN:0198506732]

growth hormone-releasing hormone activity


luteinizing hormone-releasing hormone activity

gonadotrophin hormone-releasing hormone activity

luteinizing hormone-releasing factor activity

luteinizing hormone/follicle-stimulating hormone releasing factor activity

The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone]

gonadotropin hormone-releasing hormone activity


The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals. [GOC:mah, PMID:11416225, PMID:9792536]


The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction. [GOC:mah, PMID:8902848]


The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction. [GOC:mah, PMID:12204246]


The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. [GOC:mah]


The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion. [DOI:10.1002/(SICI)1520-6327(1997)35:1, GOC:mah]


The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system. [GOC:mah, PMID:9020043]


The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis. [GOC:mah, ISBN:0198506732]


The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin. [GOC:mah, PMID:19243634]


The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects. [GOC:mah, PMID:3301403]


pituitary adenylate cyclase activating polypeptide activity

The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. [GOC:mah, PMID:19805477]

pituitary adenylyl cyclase activating polypeptide activity


thyrotropin releasing hormone activity
thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. [ISBN:0198506732]


Binding to an insulin receptor. [GOC:ai]


Binding to an insulin-like growth factor receptor. [GOC:jl]

insulin-like growth factor receptor binding


intercellular adhesion molecule-3 receptor binding

Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1. [GOC:ceb, PMID:11473836]


major histocompatibility complex binding

Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]


natural killer cell lectin-like receptor binding

Binding to a lectin-like natural killer cell receptor. [GOC:ai]


Binding to a Notch (N) protein, a surface receptor. [GOC:ceb]


Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. [ISBN:0198506732]


Binding to a patched (ptc) protein, a receptor for hedgehog proteins. [GOC:ceb, PMID:11731473]


The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant. [GOC:sgd_curators, ISBN:0198506732]


A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence. [GOC:mah, PMID:7698645]


The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. [GOC:ceb, ISBN:0198506732]


receptor tyrosine kinase-like orphan receptor binding

Binding to a receptor tyrosine kinase-like orphan receptor (Ror). [GOC:ceb, GOC:vw]


Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. [GOC:ceb, PMID:11731473]


Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel. [GOC:ceb, PMID:11938023]


Binding to a Toll protein, a transmembrane receptor. [GOC:ceb]


Binding to a torso (tor) protein, a receptor tyrosine kinase. [GOC:ceb, PMID:2927509]


Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor. [GOC:ceb, PMID:11856529]


Binding to a selenium (Se) ion. [GOC:ai]


Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]


Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]


OBSOLETE. Any substance that causes the lysis of red blood cells. [ISBN:0198506732]


Binding to oxysterol, an oxidized form of cholesterol. [GOC:curators]


Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]


Binding to a virion, either by binding to components of the capsid or the viral envelope. [GOC:ai]


Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]


Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. [GOC:jl, ISBN:0198506732]


vitamin B9 binding
folate binding
vitamin M binding

Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:jl, ISBN:0198506732]


Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [ISBN:0721662544]


OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix. [ISBN:0198506732]


OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions. [ISBN:0198506732]

calcium-dependent cell adhesion molecule activity


calcium-independent cell adhesion molecule activity

OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Binding to a cell adhesion molecule. [GOC:ai]


Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]


Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. [GOC:ai, PMID:2970671]


cell adhesion receptor regulator activity


cell adhesion receptor inhibitor activity


OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane. [EC:2.7.4.8]


OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function. [ISBN:0198547684]


OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. [EC:3.6.4.9, ISBN:0198547684]


OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity. [GOC:rb]


OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity. [GOC:rb]


OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins. [GOC:jl, PMID:11337494]


OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones. [ISBN:0198547684]


OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function. [GOC:jl, PMID:7600578, PMID:9325046]


Binding to and delivering metal ions to a target protein. [PMID:11739376]


Directly binding to and delivering copper ions to a target protein. [PMID:10790544, PMID:11739376]


superoxide dismutase copper chaperone activity

A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity. [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]


OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function. [GOC:jl, PMID:11847227]


OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]


OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease. [GOC:go_curators]


OBSOLETE. Inhibits the growth of, or directly kills, microbial cells. [GOC:go_curators]


OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells. [GOC:go_curators]


Gram-negative antibacterial peptide activity

OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells. [GOC:go_curators]


Gram-positive antibacterial peptide activity

OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells. [GOC:go_curators]


male-specific antibacterial peptide activity

OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males. [GOC:go_curators]


Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. [EC:3.2.1.17, PMID:22748813]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


cell surface antigen activity, host-interacting

OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition. [GOC:mb]


OBSOLETE. Any of a set of activities involved in the complement cascade. [GOC:jl]


OBSOLETE. (Was not defined before being made obsolete). [GOC:add]


1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity

1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity

(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity

(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity

Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. [EC:1.17.7.1, PMID:11752431]


Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+). [EC:4.1.99.12, RHEA:18457]


Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate. [EC:4.1.3.38, RHEA:16201]


aphidicolan-16 beta-ol synthase activity

Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate. [EC:4.2.3.42, PMID:12149019]


N-beta-alanyl dopamine synthetase activity

Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine. [GOC:bf, ISBN:0198506732, PMID:12900414, PMID:12957543, PMID:25229196]


Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. [MetaCyc:RXN3O-227]


D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity

Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate. [MetaCyc:H2NTPEPIM-RXN]


Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3. [GOC:jl, PMID:19567870]


Catalysis of the removal of a methyl group from N-nitrosodimethylamine. [GOC:mah]


diphosphoinositol polyphosphate phosphohydrolase activity

Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. [EC:3.6.1.52]


Catalysis of the cleavage of branch points in branched glycogen polymers. [ISBN:0198506732]


debranching enzyme maltodextrin glycosyltransferase activity

Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. [EC:2.4.1.25]


glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity

Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. [EC:3.2.1.33, ISBN:0198506732]


Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins. [EC:3.2.1.68]


Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:jl]


Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]


NAD-dependent histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. [PMID:28450737]


NAD-independent histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone. [PMID:28450737]


Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732]


Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. [ISBN:0471331309]


hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride. [GOC:jl]


hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. [GOC:jl]


Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. [EC:3.6.1.7]


Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. [GOC:ai]


diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity

adenosine tetraphosphate phosphodiesterase activity

diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity

diadenosine polyphosphate hydrolase activity

symmetrical diadenosine tetraphosphate hydrolase activity

Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+). [EC:3.6.1.41, RHEA:24252]


Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate. [GOC:pde, PMID:11139615]


dihydroneopterin monophosphate dephosphorylase activity

dihydroneopterin monophosphate phosphatase activity

Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate. [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN]


Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN]

dihydroneopterin triphosphate pyrophosphohydrolase activity


Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. [EC:3.6.1.10]


acid phosphoanhydride phosphohydrolase activity

Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. [EC:3.6.1.11]


nucleoside diphosphate phosphatase activity

nucleoside diphosphate phosphohydrolase activity

Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. [EC:3.6.1.6]


OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate. [EC:3.6.1.5, MetaCyc:APYRASE-RXN]


guanosine diphosphatase activity
GDPase activity
GDP phosphohydrolase activity
guanosine-diphosphatase activity

Catalysis of the reaction: GDP + H2O = GMP + phosphate. [EC:3.6.1.42, PMID:2989286, RHEA:22156]


UDP phosphohydrolase activity
UDPase activity
uridine diphosphatase activity
uridine-diphosphatase activity

Catalysis of the reaction: UDP + H2O = UMP + phosphate. [RHEA:64876]


unspecific diphosphate phosphohydrolase activity

nucleoside triphosphate phosphohydrolase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. [RHEA:23680]

nucleoside triphosphate hydrolase activity


Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]


adenosine diphosphosugar pyrophosphatase activity

Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. [EC:3.6.1.21]


cytidine diphosphodiacylglycerol pyrophosphatase activity

Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+). [EC:3.6.1.26, RHEA:15221]


desoxyuridine 5'-triphosphate nucleotidohydrolase activity

Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. [RHEA:10248]


guanosine pentaphosphate phosphohydrolase activity

guanosine pentaphosphate phosphatase activity

guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity

guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity

Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. [EC:3.6.1.40]


diphosphate hydrolysis-driven proton transmembrane transporter activity

PP(i) hydrolysis-driven proton transmembrane transporter activity

pyrophosphate hydrolysis-driven proton transmembrane transporter activity

Enables the transmembrane transport of one proton (H+), driven by the hydrolysis of pyrophosphate, and generating a proton motive force. [GOC:mtg_transport, ISBN:0815340729, Wikipedia:Proton-pumping_pyrophosphatase]


diphosphate phosphohydrolase activity
pyrophosphate phosphohydrolase activity
inorganic pyrophosphatase activity

Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate. [EC:3.6.1.1, RHEA:24576]


nicotinamide adenine dinucleotide pyrophosphatase activity

Catalysis of the reaction: NAD+ + H2O = AMP + NMN. [RHEA:11800]


Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. [EC:3.6.1.9]


Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+). [EC:3.6.1.31, RHEA:22828]

phosphoribosyladenosine triphosphate pyrophosphatase activity


thiamine pyrophosphatase activity
thiamin-pyrophosphatase activity
TPPase activity
thiamin pyrophosphatase activity
thiaminpyrophosphatase activity

Catalysis of the reaction: TPP + H2O = TMP + phosphate. [GOC:ai, RHEA:27998]


Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770]


Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. [EC:3.6.1.45]


hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides

hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-. [GOC:ai]


hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement

OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]


OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome. [EC:3.6.4.2]


Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. [PMID:10910766]


OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction. [EC:3.6.4.1]