Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. [GOC:ai, ISBN:0198506732]


G-protein coupled nucleotide receptor activity

nucleotide receptor activity, G-protein coupled

nucleotide receptor activity, G protein coupled

G protein coupled nucleotide receptor activity

G protein-coupled nucleotide receptor activity

Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, IUPHAR_GPCR:1294]


G protein coupled purinergic nucleotide receptor activity

purinergic nucleotide receptor activity, G-protein coupled

purinergic nucleotide receptor activity, G protein coupled

G-protein coupled purinergic nucleotide receptor activity

G protein-coupled purinergic nucleotide receptor activity

Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, PMID:9755289]


G-protein coupled adenosine receptor activity

G protein coupled adenosine receptor activity

adenosine receptor activity, G-protein coupled

adenosine receptor activity, G protein coupled

G protein-coupled adenosine receptor activity

Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah, PMID:9755289]


G protein coupled A1 adenosine receptor activity

A1 adenosine receptor activity, G protein coupled

G-protein-coupled A1 adenosine receptor activity

A1 adenosine receptor activity, G-protein coupled


G-protein-coupled A2A adenosine receptor activity

A2A adenosine receptor activity, G protein coupled

G protein coupled A2A adenosine receptor activity

A2A adenosine receptor activity, G-protein coupled


A2B adenosine receptor activity, G protein coupled

G protein coupled A2B adenosine receptor activity

G-protein-coupled A2B adenosine receptor activity

A2B adenosine receptor activity, G-protein coupled


A3 adenosine receptor activity, G protein coupled

G-protein-coupled A3 adenosine receptor activity

G protein coupled A3 adenosine receptor activity

A3 adenosine receptor activity, G-protein coupled


ADP-activated nucleotide receptor activity


ATP-activated nucleotide receptor activity


UDP-activated nucleotide receptor activity


UTP-activated nucleotide receptor activity


Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]


Combining with platelet activating factor to initiate a change in cell activity. [GOC:mah]

platelet activating factor receptor activity


Combining with a protein hormone to initiate a change in cell activity. [GOC:mah]


follicle stimulating hormone receptor activity

follicle-stimulating hormone receptor activity

Combining with follicle-stimulating hormone to initiate a change in cell activity. [GOC:mah]


gonadotrophin-releasing hormone receptor activity

Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. [GOC:mah]

gonadotropin-releasing hormone receptor activity


Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity. [GOC:mah]

melanin-concentrating hormone receptor activity


thyroid-stimulating hormone receptor activity

thyroid stimulating hormone receptor activity

Combining with thyroid-stimulating hormone to initiate a change in cell activity. [GOC:mah]


Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph]


Combining with ghrelin to initiate a change in cell activity. [GOC:mah, PMID:17983853]

growth hormone secretagogue receptor activity


thyrotropin-releasing hormone receptor activity

Combining with thyrotropin-releasing hormone to initiate a change in cell activity. [GOC:mah]


Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]


calcitonin gene-related polypeptide receptor activity

calcitonin gene-related peptide receptor activity

Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. [GOC:mah, PMID:12037140]


Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, GOC:signaling, PMID:21649645]


corticotrophin-releasing factor receptor activity

Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. [PMID:12032352]


glucose-dependent insulinotropic polypeptide receptor activity

gastric inhibitory peptide receptor activity

Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein. [GOC:mah, PMID:8243312]


Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, GOC:signaling, PMID:22438981]


Combining with growth hormone-releasing hormone to initiate a change in cell activity. [PMID:12529933]

growth hormone-releasing hormone receptor activity


Combining with parathyroid hormone to initiate a change in cell activity. [GOC:mah]


pituitary adenylyl cyclase activating protein receptor activity

pituitary adenylate cyclase activating polypeptide receptor

pituitary adenylate cyclase-activating polypeptide receptor activity

A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. [GOC:dph, GOC:tb]

pituitary adenylate cyclase activating protein receptor activity


Combining with secretin to initiate a change in cell activity. [GOC:mah]


vasoactive intestinal polypeptide receptor activity

Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. [GOC:mah]


Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]


extracellular-glutamate-gated chloride channel activity

extracellularly glutamate-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:mtg_transport, ISBN:0815340729]


Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [ISBN:0198506732]


alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium. [GOC:mah, PMID:10049997, PMID:8804111]


kainate selective glutamate receptor activity

An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. [GOC:mah, PMID:10049997, PMID:8804111]


N-methyl-D-aspartate selective glutamate receptor activity

An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. [GOC:mah, PMID:10049997]


hematopoietin/interferon-class (D200-domain) cytokine receptor activity


ciliary neurotrophic factor receptor activity

Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]


leukemia inhibitory factor receptor beta-protein activity


Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]


glial cell line-derived neurotrophic factor receptor activity

glial cell-derived neurotrophic factor receptor activity

Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]


Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]


leukemia inhibitory factor receptor activity

Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:mah, GOC:signaling]


Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]


Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]


Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, ISBN:0198547684]


Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling, PMID:10025961]


lipoprotein receptor activity
lipoprotein particle receptor activity

Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. [GOC:bf, GOC:mah, PMID:12827279]

plasma lipoprotein particle receptor activity


very-low-density lipoprotein particle receptor activity

Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis. [GOC:bf, ISBN:0198506732]

very-low-density lipoprotein receptor activity


HLA-A specific activating MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


HLA-A specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


HLA-B specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


HLA-C specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


neurotensin receptor activity, non-G-protein coupled

non G protein coupled neurotensin receptor activity

neurotensin receptor activity, non G protein coupled

non-G-protein-coupled neurotensin receptor activity

non-G-protein coupled neurotensin receptor activity

neurotensin receptor activity, non-G protein-coupled

Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins. [GOC:mah, GOC:signaling, PMID:9756851]


OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]


OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity. [GOC:go_curators]


Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. [GOC:bf, GOC:go_curators, PMID:9278137]


non-tyrosine kinase FGF receptor activity

non-tyrosine kinase fibroblast growth factor receptor activity

Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity. [GOC:signaling, PMID:11418238]


Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]


Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. [GOC:signaling, ISBN:0198506732]


purinoreceptor
purinergic nucleotide receptor activity
purinoceptor

Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]


Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. [GOC:dph, GOC:tb]


signaling pattern recognition receptor activity


Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:18840757]


Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]


Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:15239958]


Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]


Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:9521906]


Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates. [GOC:bf, PMID:2678449, PMID:3011819]


vasopressin activated calcium mobilizing receptor activity


Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis. [GOC:bf, PMID:12429745]


acetylcholine receptor regulator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. [GOC:mah]


acetylcholine receptor activator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased. [GOC:mah]


acetylcholine receptor inhibitor activity

Binds to and stops, prevents or reduces the activity of an acetylcholine receptor. [GOC:mah]


receptor signaling complex adaptor activity

receptor signaling complex scaffold activity

receptor signalling complex scaffold activity

receptor signaling complex scaffold protein activity

receptor signalling complex adaptor activity

signaling receptor complex adaptor activity

The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. [GOC:mah]


The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. [PMID:12511654, PMID:15213240, PMID:9405336]


OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location. [GOC:ai]


OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location. [PMID:10354567]


PKC alpha binding
protein kinase C alpha binding
PKC binding
PKC eta binding
protein kinase C eta binding
protein kinase C delta binding
PKC delta binding


transforming growth factor beta receptor anchoring activity

OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location. [GOC:ai]


JAK pathway signal transduction adaptor activity

The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07]


small GTPase regulatory/interacting protein activity


Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. [GOC:mah]


Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. [GOC:mah]


Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. [GOC:mah]


guanyl-nucleotide exchange factor adaptor activity

The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]


transmembrane receptor protein tyrosine kinase adaptor protein activity

transmembrane receptor protein tyrosine kinase adaptor activity

The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848]


transmembrane receptor protein tyrosine kinase docking protein activity


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. [GOC:mah, GOC:vw]


extracellular matrix constituent, lubricant activity

Functions as a lubricant for an extracellular matrix, such as a mucous membrane. [GOC:mah]


The action of a molecule that contributes to the structural integrity of bone. [GOC:mah]


The action of a molecule that contributes to the structural integrity of a cell wall. [GOC:mah]


The action of a molecule that contributes to the structural integrity of chromatin. [GOC:ai]


The action of a molecule that contributes to the structural integrity of a cuticle. [GOC:jl]


structural constituent of chitin-based cuticle

The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]


structural constituent of adult chitin-based cuticle

The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]


structural constituent of chitin-based larval cuticle

The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]


structural constituent of pupal chitin-based cuticle

The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]


structural constituent of collagen and cuticulin-based cuticle

The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans. [GOC:jl, GOC:mtg_sensu]


The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah]


structural constituent of cutaneous appendage

The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers. [GOC:mah, ISBN:0878932437]


The action of a molecule that contributes to the structural integrity of the lens of an eye. [GOC:mah]


The action of a molecule that contributes to the structural integrity of a muscle fiber. [GOC:mah]


The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. [GOC:mah]


The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules. [GOC:mah, PMID:25802992]


structural constituent of peritrophic matrix

structural constituent of peritrophic membrane

The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]


The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah]


The action of a molecule that contributes to the structural integrity of tooth enamel. [GOC:mah]


OBSOLETE. The action of reducing the surface tension of a liquid. [GOC:jl, ISBN:0198506732]


OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species. [GOC:jl, ISBN:0198506732]


OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell. [PMID:10839820]


OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell. [GOC:ai]


OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. [GOC:mah]


Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. [GOC:ai]


translation factor activity, non-nucleic acid binding

A translation regulator activity that does not involve binding to nucleic acids. [GOC:ai, GOC:dph, GOC:tb]


translation repressor activity, non-nucleic acid binding

Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid. [GOC:clt]


Antagonizes ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai, GOC:clt]


Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. [GOC:ai, GOC:dgf]


amine/polyamine transmembrane transporter activity

amino acid-polyamine transmembrane transporter activity

Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


acetylcholine transmembrane transporter activity

Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out). [TC:2.A.1.2.13]


amino-acid betaine transmembrane transporter activity

Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid. [GOC:ai]


choline transmembrane transporter activity

Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:ai]


amino acid/choline transmembrane transporter activity

OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in). [TC:2.A.22.3.5]


dopamine transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in). [PMID:21752877, PMID:22519513, TC:2.A.22.1.3]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out). [TC:2.A.1.2.11, TC:2.A.1.2.12]


norepinephrine transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in). [PMID:21752877, PMID:22519513, TC:2.A.22.1.2]


polyamine transmembrane transporter activity

Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other. [GOC:ai]


amino acid transmembrane transporter activity

Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane. [GOC:ai]


high-affinity basic amino acid transporter activity


high affinity glutamine permease activity


high affinity histidine permease activity


high-affinity arginine transporter activity


high affinity lysine transporter activity


L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity

L-lysine efflux transmembrane transporter activity

Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


amino acid:cation symporter activity
cation:amino acid symporter activity
cation/amino acid symporter

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). [GOC:ai]


branched-chain amino acid:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in). [TC:2.A.26.1.1]


OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in). [TC:2.A.26.1.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). [GOC:ai]


aromatic amino acid:hydrogen symporter activity

aromatic amino acid:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in). [TC:2.A.3.1.3]


gamma-aminobutyric acid permease activity

gamma-aminobutyric acid:hydrogen symporter activity

gamma-aminobutyric acid:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in). [TC:2.A.3.1.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in). [TC:2.A.3.1.1]


OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in). [TC:2.A.1.6.4]


cationic amino acid transmembrane transporter activity


high-affinity glutamate transporter activity


hydroxy/aromatic amino acid permease activity

OBSOLETE. Permease for hydroxy and aromatic amino acids. [GOC:ai]


high-affinity tryptophan transporter activity


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


threonine efflux permease activity
threonine export transporter activity

threonine efflux transmembrane transporter activity

Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]


p-aminobenzoyl-glutamate uptake permease activity

p-aminobenzoyl-glutamate uptake transmembrane transporter activity


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in). [GOC:ai]


cystine porter activity
lysosomal cystine transporter


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out). [TC:2.A.3.8.5]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out). [TC:2.A.3.2.1]


Enables the transfer of S-methylmethionine from one side of a membrane to the other. [GOC:ai]

S-methylmethionine transmembrane transporter activity


sodium/excitatory amino acid symporter activity

sodium/excitatory amino acid cotransporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). [GOC:ai]


insulin-activated sodium:amino acid symporter activity

insulin-activated sodium:amino acid transporter activity

insulin-activated sodium/amino acid transporter activity


neutral, cationic amino acid:sodium:chloride symporter activity


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out). [TC:2.A.1.2.16]


taurine transmembrane transporter activity

Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). [TC:2.A.22.3.3]


urea active transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in). [TC:2.A.21.6.1]


OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in). [TC:2.A.23.1.1]


sodium/excitatory glutamate symporter activity

sodium/excitatory glutamate cotransporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). [TC:2.A.27.1.1]


aromatic amino acid transporter activity


branched-chain aliphatic amino acid transmembrane transporter activity

branched-chain aliphatic amino acid transporter activity

branched-chain amino acid transmembrane transporter activity

Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. [GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729]


gamma-aminobutyric acid:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in). [TC:2.A.22.3.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). [TC:2.A.22.2.1]


OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in). [TC:2.A.23.4.1]


S-adenosyl methionine transporter activity

S-adenosyl-L-methionine transmembrane transporter activity

S-adenosylmethionine transmembrane transporter activity

Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. [GOC:ai]


Bonds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:mah]


Modulates the activity of a calcium channel. [GOC:mah]


Binds to and stops, prevents, or reduces the activity of a calcium channel. [GOC:mah]


Binds to and stops, prevents, or reduces the activity of a channel. [GOC:mah]


Binds to and stops, prevents, or reduces the activity of an ion channel. [GOC:mah]


Binds to and stops, prevents, or reduces the activity of a chloride channel. [GOC:mah]


Binds to and stops, prevents, or reduces the activity of a potassium channel. [GOC:mah]


Binds to and stops, prevents, or reduces the activity of a sodium channel. [GOC:mah]


Binds to and modulates the activity of a chloride channel. [GOC:mah]


Binds to and modulates the activity of a potassium channel. [GOC:dos, GOC:mah]


Binds to and modulates the activity of a sodium channel. [GOC:mah]


low voltage-gated potassium channel auxiliary protein activity

low voltage-dependent potassium channel auxiliary protein activity


sodium channel auxiliary protein activity


disaccharide transmembrane transporter activity

Enables the transfer of disaccharide from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


lactose, galactose:hydrogen symporter activity

OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in). [TC:2.A.1.1.9]


lactose/glucose efflux transporter activity

OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out). [TC:2.A.1.20.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in). [TC:2.A.1.1.9, TC:2.A.1.5.1]


Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport]


maltose:hydrogen symporter activity
hydrogen/maltose transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in). [TC:2.A.1.1.10]


melibiose transmembrane transporter activity

Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


sucrose transmembrane transporter activity

Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in). [TC:2.A.1.5.3]


glucuronoside transmembrane transporter activity

Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


monosaccharide transmembrane transporter activity

Enables the transfer of a monosaccharide from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


hexose transmembrane transporter activity

Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in). [TC:2.A.1.1.13]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in). [TC:2.A.1.7.1]


OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in). [TC:2.A.1.1.6]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in). [TC:2.A.1.1.1, TC:2.A.1.1.9]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]


alpha-glucoside transmembrane transporter activity

Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]


Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]

beta-glucoside transmembrane transporter activity


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in). [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6]


glucose-6-phosphate transmembrane transporter activity

Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in). [TC:2.A.1.1.5]


pentose transmembrane transporter activity

Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in). [TC:2.A.1.1.2]


pyrimidine nucleotide-sugar transmembrane transporter activity

Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


CMP-sialic acid transmembrane transporter activity

CMP-N-acetylneuraminate transmembrane transporter activity

Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


GDP-fucose transmembrane transporter activity

Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


GDP-mannose transmembrane transporter activity

Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


UDP-galactose transmembrane transporter activity

Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


UDP-glucose transmembrane transporter activity

Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


UDP-glucuronic acid transmembrane transporter activity

Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


UDP-N-acetylgalactosamine transmembrane transporter activity

Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


UDP-N-acetylglucosamine transmembrane transporter activity

Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


UDP-xylose transmembrane transporter activity

Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. [GOC:ai]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


oligosaccharide transporting porin activity

Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport]


raffinose transmembrane transporter activity

Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in). [TC:2.A.1.5.2]


sialic acid transmembrane transporter activity

Enables the transfer of sialic acid from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in). [TC:2.A.10.1.1]


carbohydrate:cation symporter activity
cation/sugar symporter activity
cation:sugar symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). [GOC:ai]


hydrogen:sugar symporter activity
sugar:proton symporter activity
sugar:hydrogen ion symporter activity
carbohydrate:proton symporter activity
sugar:hydrogen symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). [TC:2.A.1.1]


high-affinity hydrogen:glucose symporter activity

high-affinity hydrogen/glucose transporter activity

high-affinity hydrogen:glucose transporter activity

high-affinity glucose:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]


low-affinity hydrogen/glucose transporter activity

low-affinity hydrogen:glucose symporter activity

low-affinity hydrogen:glucose transporter activity

low-affinity glucose:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in). [TC:2.A.7.6]


general alpha-glucoside:hydrogen symporter activity

general alpha-glucoside:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose. [TC:2.A.1.1.11]


glucose 6-phosphate:phosphate antiporter activity


glycerol-phosphate:inorganic phosphate antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out). [TC:2.A.1.4.3]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+. [TC:2.A.2.-.-]


hexose-phosphate:inorganic phosphate antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out). [TC:2.A.1.4.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in). [TC:2.A.1.-.-]


OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in). [TC:2.A.8.1.2]


lactate:hydrogen porter activity
lactate:hydrogen symporter activity
lactate:proton porter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in). [TC:2.A.14.1.1]


beta-glucan transmembrane transporter activity

Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


capsule polysaccharide transporter activity

capsular polysaccharide transmembrane transporter activity


lipopolysaccharide transmembrane transporter activity

Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


teichoic acid transmembrane transporter activity


sialate/cation symporter activity
cation:sialate symporter activity
cation/sialate symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in). [TC:2.A.1.14.10]


energizer of outer membrane receptor-mediated transport activity


electrochemical potential-driven transporter activity

secondary active transmembrane transporter activity

Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]


countertransporter activity
antiporter activity
solute:solute antiporter activity
porter
exchange transporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). [GOC:ai, GOC:mtg_transport]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). [GOC:mah]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out). [TC:2.A.47.3.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out). [TC:2.A.53.2.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out). [TC:2.A.47.3.3]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). [TC:2.A.37.-.-]


pH-dependent sodium:hydrogen antiporter activity


dicarboxylate (succinate/fumarate/malate) antiporter activity

OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


dicarboxylate:inorganic phosphate antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out). [TC:2.A.29.2.3]


monovalent cation:hydrogen antiporter activity

monovalent cation:proton antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out). [TC:2.A.29.2.1]


Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out). [TC:2.A.1.25.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). [TC:2.A.19.-.-]


calcium, potassium:sodium antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). [TC:2.A.19.4.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). [TC:2.A.19.2.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). [GOC:curators, PMID:16371597]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out). [TC:2.A.1.2.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances. [GOC:ai, ISBN:3527307206, Wikipedia:Azole]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out). [TC:2.A.1.3.1]


OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in). [TC:2.A.1.2.7]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out). [TC:2.A.1.2.17]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out). [TC:2.A.1.2.6]


carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity

OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out). [TC:2.A.1.2.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). [TC:2.A.1.2.4]


organophosphate:inorganic phosphate antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out). [TC:2.A.1.4.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out). [TC:2.A.29.13.1]


ATP/ADP exchanger
ADP/ATP translocase
ADP/ATP carrier protein
adenine nucleotide translocase
ATP:ADP antiporter activity

Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). [TC:2.A.29.1.1]


carnitine:acyl carnitine carrier activity

carnitine/acyl carnitine carrier activity

carnitine:acyl carnitine antiporter activity

Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial). [PMID:9032458]


formate efflux transmembrane transporter activity

Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]


glutathione-regulated potassium exporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state. [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2]


cadmium ion transmembrane transporter activity

Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. [GOC:dgf]


OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport. [TC:2.A.4.2.2]


OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport. [TC:2.A.4.2.1]


zinc efflux transmembrane transporter activity

Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]


cobalt ion transmembrane transporter activity

Enables the transfer of cobalt (Co) ions from one side of a membrane to the other. [GOC:dgf]


copper ion transmembrane transporter activity

Enables the transfer of copper (Cu) ions from one side of a membrane to the other. [GOC:ai]


heavy metal ion:hydrogen symporter activity

OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+. [TC:2.A.55.2.1, TC:2.A.55.2.2]


high affinity metal ion uptake transporter activity

OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+. [TC:2.A.55.1.1]


ferric triacetylfusarinine C transmembrane transporter activity

Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other. [GOC:ai]


ferric triacetylfusarinine C:hydrogen symporter activity

ferric triacetylfusarinine C:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in). [TC:2.A.1.16.3]


transmembrane iron ion permease activity

iron ion transmembrane transporter activity

Enables the transfer of iron (Fe) ions from one side of a membrane to the other. [GOC:ai]


high affinity ferric uptake transmembrane transporter activity


siderophore-iron transporter activity
iron-siderophore transporter activity

siderophore transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). [TC:2.A.1.16.-]


ferric enterobactin:hydrogen symporter activity

ferric enterobactin:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in). [TC:2.A.1.16.2]


OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force. [TC:2.A.5.-.-]


high affinity zinc uptake transmembrane transporter activity

high-affinity zinc uptake transmembrane transporter activity

high-affinity zinc transmembrane transporter activity

Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.5.1.1]


lead ion transmembrane transporter activity

Enables the transfer of lead (Pb) ions from one side of a membrane to the other. [GOC:ai]


low affinity metal ion uptake transporter activity

OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+. [TC:2.A.55.1.2]


manganese ion transmembrane transporter activity

Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. [GOC:dgf]


mercury ion transmembrane transporter activity

Enables the transfer of mercury (Hg) ions from one side of a membrane to the other. [GOC:ai]


molybdate ion transmembrane transporter activity

Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. [ISBN:0198506732]


nickel cation transmembrane transporter activity

Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. [GOC:ai]


tellurite-resistance uptake permease activity

tellurite-resistance uptake transmembrane transporter activity

tellurite uptake transmembrane transporter activity


vanadium ion transmembrane transporter activity

Enables the transfer of vanadium (V) ions from one side of a membrane to the other. [GOC:ai]


zinc ion transmembrane transporter activity

Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. [GOC:dgf]


low-affinity zinc ion transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:mtg_transport, ISBN:0815340729]


inorganic phosphate transmembrane transporter activity

Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]


inorganic solute uptake transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity

Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. [GOC:mtg_transport, ISBN:0815340729]


phosphate ion carrier activity
phosphate:hydrogen symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in). [TC:2.A.1.9.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). [GOC:ai]


high affinity inorganic phosphate:sodium symporter activity

high-affinity inorganic phosphate:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.20.2.2]


sodium:inorganic phosphate symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in). [TC:2.A.1.14.6]


nitrite efflux transmembrane transporter activity

Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]


high-affinity secondary active nitrite transmembrane transporter activity

Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport, ISBN:0815340729]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


3-hydroxyphenyl propionate porter activity


hydrogen:acetate symporter activity
acetate:hydrogen symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in). [TC:2.A.44.4.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in). [TC:2.A.1.6.2]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in). [TC:2.A.1.6.1]


high affinity sodium:dicarboxylate cotransporter activity


low affinity sodium:dicarboxylate cotransporter activity


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in). [TC:2.A.16.2.1]


monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity


OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in). [TC:2.A.47.1.5]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in). [TC:2.A.1.6.6]


Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport, ISBN:0815340729]

tricarboxylate secondary active transmembrane transporter activity


proton-dependent oligopeptide transporter activity

proton-dependent oligopeptide secondary active transmembrane transporter activity

Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. [GOC:mtg_transport, OMIM:600544]


high-affinity oligopeptide transporter activity

high affinity oligopeptide transporter activity

high-affinity oligopeptide transmembrane transporter activity

Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [GOC:mtg_transport]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in). [GOC:mah, PMID:10066586, PMID:1990981]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement. [GOC:mtg_transport, TC:2.A.17.-.-]


secondary active sulphate transmembrane transporter activity

Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]

secondary active sulfate transmembrane transporter activity


high affinity sulfate transmembrane transporter activity

high affinity sulphate permease activity

high-affinity sulfate transmembrane transporter activity

Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations. [GOC:mtg_transport]


sodium:sulphate symporter activity
sodium:sulfate cotransporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in). [TC:2.A.47.1.2]


sulfate/hydrogen symporter activity
sulphate:hydrogen symporter activity
sulfate:hydrogen symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). [TC:2.A.53.-.-]


high affinity sulfate:hydrogen symporter activity

high affinity sulphate:hydrogen symporter activity

high affinity sulfate:proton symporter activity

high-affinity sulfate:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mah]


low affinity sulfate:proton symporter activity

low affinity sulfate:hydrogen symporter activity

low affinity sulphate:hydrogen symporter activity

low-affinity sulfate:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:mah, PMID:7568135]


cotransporter activity
symporter activity
porter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). [TC:2.A.1.14.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in). [PMID:8688077]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). [PMID:31747317]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). [TC:2.A.30.1.5]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in). [TC:2.A.30.4.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). [TC:2.A.30.1.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in). [TC:2.A.38.3.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). [TC:2.A.31.2.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). [GOC:ai]


sodium-dependent L-ascorbic acid transporter


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in). [GOC:ai]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). [GOC:ai]

sodium-dependent nucleoside transporter activity


purine-specific nucleoside:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). [TC:2.A.41.2.1]


pyrimidine- and adenine-specific:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in). [TC:2.A.41.2.3]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). [GOC:ai]


nucleoside:hydrogen ion symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in). [TC:2.A.1.10.1, TC:2.A.41.1.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in). [TC:2.A.38.-.-]


quaternary ammonium group:hydrogen symporter activity

quaternary ammonium group:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in). [GOC:ai]


glycine betaine:hydrogen symporter activity

glycine betaine:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in). [TC:2.A.15.1.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). [GOC:ai]


monovalent anion:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in). [TC:2.A.21.5.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). [TC:2.A.21.5.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in). [TC:2.A.21.4.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). [TC:2.A.22.3.4]


serotonin transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in). [PMID:21752877, PMID:22519513, TC:2.A.22.1.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). [TC:2.A.28.1.1]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). [TC:2.A.28.-.-]


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in). [TC:2.A.21.1.1]


single-species transporter activity
facilitated diffusion carrier

Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]


OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells. [GOC:ai]


oxidative phosphorylation uncoupler activity

Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. [PMID:15738989, PMID:16179945]


decarboxylation-driven active transmembrane transporter activity

Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-]


light-driven pumps
Light absorption-driven transporters

light-driven active transmembrane transporter activity

Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-]


methyl transfer-driven active transmembrane transporter activity

Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-]


oxidoreduction-driven active transmembrane transporter activity

Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]


P-P-bond-hydrolysis-driven transmembrane transporter activity


ATPase-coupled protein transmembrane transporter activity

P-P-bond-hydrolysis-driven protein transmembrane transporter activity

protein-transmembrane transporting ATPase activity

Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. [GOC:mtg_transport, ISBN:0815340729]


nonselective channel activity
channel/pore class transporter activity

Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. [GOC:mtg_transport, ISBN:0815340729]


A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. [GOC:dgh]


A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]


Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2. [GOC:mtg_transport, GOC:pr]


Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport]


Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


glycine-inhibited chloride channel activity

extracellular-glycine-gated chloride channel activity

extracellularly glycine-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:mtg_transport, ISBN:0815340729]


histamine-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


intracellular calcium activated chloride channel activity

Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport]


voltage-dependent chloride channel activity

Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]


organellar voltage gated chloride channel activity

organellar voltage-dependent chloride channel activity

organellar voltage-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane. [GOC:mtg_transport, ISBN:0815340729]


voltage-dependent ion-selective channel activity

voltage-gated ion-selective channel activity


Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. [GOC:dph, GOC:tb]


Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]


inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor]


intracellular ligand-gated calcium channel activity


Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. [GOC:dph, GOC:tb]

ryanodine-sensitive calcium-release channel activity


A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]


stretch-activated, cation-selective, calcium channel activity

Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching. [GOC:mtg_transport]


depolarization-activated voltage gated calcium channel activity

voltage-dependent calcium channel activity

depolarization-activated voltage-gated calcium channel activity

voltage-gated calcium ion channel activity

Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]


dihydropyridine-sensitive calcium channel activity


high voltage gated calcium channel activity

high voltage-dependent calcium channel activity

high voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]


light-activated voltage gated calcium channel activity

light-activated voltage-dependent calcium channel activity

light-activated voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport]


low voltage-gated calcium channel activity

low voltage-dependent calcium channel activity

Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]

low voltage gated calcium channel activity


Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


intracellular cyclic nucleotide activated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]


intracellular cAMP activated cation channel activity

intracellular 3',5' cAMP activated cation channel activity

intracellular 3',5'-cAMP activated cation channel activity

intracellular adenosine 3',5'-cyclophosphate activated cation channel activity

intracellular cyclic AMP activated cation channel activity

intracellular cAMP-activated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]


intracellular cGMP activated cation channel activity

intracellular cGMP-activated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]


Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport]

calcium-activated potassium channel activity


SK calcium-activated potassium channel activity

small conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, OMIM:602754]


intracellular sodium activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification. [GOC:mtg_transport, PMID:12628167]


voltage-gated potassium ion channel activity

voltage-dependent potassium channel activity

voltage gated potassium channel activity

Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]

voltage-gated potassium channel activity


Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513]

delayed rectifier potassium channel activity


inward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [GOC:cb, GOC:mah, PMID:14977398]


ATP-activated inward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. [GOC:cb, GOC:mah]


G protein activated inward rectifier potassium channel activity

G-protein enhanced inward rectifier potassium channel activity

G-protein-activated inward rectifier potassium channel activity

G-protein-enhanced inward rectifier potassium channel activity

G protein enhanced inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. [GOC:cb, GOC:mah]


Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration. [GOC:mah, PMID:8917578]

open rectifier potassium channel activity


outward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah]


A-type (transient outward) potassium channel activity

Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential. [GOC:mah, PMID:5575340]


Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]

amiloride-sensitive sodium channel activity


voltage-dependent sodium channel activity

voltage-gated sodium ion channel activity

Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]


extracellular ligand-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


excitatory extracellular ligand-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. [GOC:mah, ISBN:0323037070]