Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). [EC:2.7.1.137, RHEA:12709]


phosphatidylinositol 3-kinase activity, class I

OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity. [PMID:9759495]


phosphatidylinositol 3-kinase, class I, catalyst activity

OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. [EC:2.7.1.137]


phosphatidylinositol 3-kinase, class I, regulator activity


phosphatidylinositol 3-kinase activity, class II

OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine. [PMID:9759495]


phosphatidylinositol 3-kinase activity, class III

OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol. [PMID:9759495]


phosphatidylinositol monophosphate kinase activity

phosphatidylinositol phosphate kinase activity

Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. [EC:2.7.1.-, PMID:9759495]


Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). [EC:2.7.1.150, RHEA:13609]

phosphatidylinositol 3-phosphate 5-kinase activity


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). [EC:2.7.1.68, RHEA:14425]


Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [EC:2.7.1.149]


Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate. [EC:2.7.1.95, RHEA:24256]


Catalysis of the phosphorylation of a simple or complex lipid. [GOC:hjd]


ceramide kinase activity
acylsphingosine kinase activity

Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate. [EC:2.7.1.138]


Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. [EC:2.7.1.91]


Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+). [EC:2.7.1.36, RHEA:17065]


nicotinamide adenine dinucleotide kinase activity

nicotinamide adenine dinucleotide kinase (phosphorylating)

Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). [EC:2.7.1.23, RHEA:18629]


nucleobase, nucleoside, nucleotide kinase activity


guanosine 3',5'-polyphosphate synthase activity

guanosine pentaphosphate synthetase activity

guanosine 5',3'-polyphosphate synthetase activity

Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. [EC:2.7.6.5]


Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. [GOC:ai]


adenosine kinase (phosphorylating)
adenosine kinase activity
adenosine 5-phosphotransferase activity

Catalysis of the reaction: ATP + adenosine = ADP + AMP. [EC:2.7.1.20, PMID:11223943]


D. melanogaster deoxynucleoside kinase activity

Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. [EC:2.7.1.145]


Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+). [EC:2.7.1.76, RHEA:23452]


Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. [EC:2.7.1.74]


Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+). [EC:2.7.1.113, RHEA:19201]


Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. [EC:2.7.1.21]


pyrimidine ribonucleoside kinase activity

Catalysis of the reaction: ATP + uridine = ADP + UMP. [EC:2.7.1.48]


nucleoside 5'-diphosphate kinase activity

nucleoside diphosphate (UDP) kinase activity

Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]

nucleoside 5'-diphosphate phosphotransferase activity


adenylate kinase activity
5'-AMP-kinase activity
adenylokinase activity
ATP:AMP phosphotransferase activity

Catalysis of the reaction: ATP + AMP = 2 ADP. [EC:2.7.4.3]


pyrimidine nucleoside monophosphate kinase activity

Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. [EC:2.7.4.14]


ATP:(d)GMP phosphotransferase activity
5'-GMP kinase activity
guanosine monophosphate kinase activity
ATP:GMP phosphotransferase activity
GMP kinase activity

Catalysis of the reaction: ATP + GMP = ADP + GDP. [EC:2.7.4.8]


deoxythymidine 5'-monophosphate kinase activity

thymidylate monophosphate kinase activity

Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. [EC:2.7.4.9]


Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. [GOC:go_curators]


pantothenate kinase (phosphorylating) activity

Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. [EC:2.7.1.33]


Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products. [EC:4.1.1.32]


phosphoenolpyruvate carboxykinase (ATP) activity

phosphopyruvate carboxykinase (adenosine triphosphate)

Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate. [EC:4.1.1.49, RHEA:18617]

ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)


phosphoenolpyruvate carboxykinase (pyrophosphate) activity

diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)

phosphoenolpyruvate carboxykinase (diphosphate) activity

Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate. [EC:4.1.1.38, RHEA:22356]


phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)

Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-. [EC:4.1.1.31]

phosphopyruvate (phosphate) carboxylase activity


3-phosphoglyceric acid phosphokinase activity

Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). [EC:2.7.2.3, RHEA:14801]


Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. [EC:2.7.4.7]


mevalonic acid phosphate kinase activity

Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+). [EC:2.7.4.2, RHEA:16341]


ribulose-5-phosphate kinase activity
ribulose phosphate kinase activity
phosphoribulokinase activity
phosphoribulokinase (phosphorylating)
PRK
5-phosphoribulose kinase activity
PRuK
PKK

Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+). [EC:2.7.1.19, RHEA:19365]


Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). [EC:2.7.4.1]


Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate. [EC:2.7.2.15]


Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [MetaCyc:PROTEIN-KINASE-RXN]


Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. [EC:2.7.13.3, GOC:mah]


Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine. [EC:2.7.13.1]


Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine. [EC:2.7.13.2]


transmembrane receptor histidine kinase activity

Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. [GOC:lr, GOC:mah]


transmembrane histidine kinase cytokinin receptor activity

Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. [GOC:lr, GOC:mah]


phosphatidylinositol-3-phosphate protein kinase activity

Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]

3-phosphoinositide-dependent protein kinase activity


calcium-dependent protein serine/threonine kinase activity

Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. [GOC:mah]


calmodulin-dependent protein kinase I activity

Ca2+/calmodulin-dependent protein kinase kinase activity

calcium/calmodulin-dependent protein kinase type II activity

Ca2+/calmodulin-dependent protein kinase 1 activity

ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity

multifunctional calcium/calmodulin regulated protein kinase activity

Ca2+/calmodulin-dependent protein kinase activity

Ca2+/calmodulin-dependent protein kinase II activity

multifunctional calcium- and calmodulin-regulated protein kinase activity

CaM-regulated serine/threonine kinase activity

Ca2+/calmodulin-dependent protein kinase IV activity

Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity

Ca2+/calmodulin-dependent protein kinase kinase beta activity

caldesmon kinase (phosphorylating) activity

calcium- and calmodulin-dependent protein kinase activity

calcium/calmodulin-dependent protein kinase activity

Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. [GOC:mah, PMID:11264466]


ATP:elongation factor 2 phosphotransferase activity

calmodulin-dependent protein kinase III activity

eukaryotic elongation factor 2 kinase activity

Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate. [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN]


calmodulin-dependent myosin heavy chain kinase activity

ATP:myosin heavy-chain O-phosphotransferase activity

Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate. [EC:2.7.11.7]


myosin light-chain kinase (phosphorylating) activity

myosin light chain protein kinase activity

calcium/calmodulin-dependent myosin light chain kinase activity

Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. [EC:2.7.11.18]


phosphorylase kinase (phosphorylating) activity

phosphorylase kinase, intrinsic catalyst activity

Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. [EC:2.7.11.19]


phosphorylase kinase, intrinsic regulator activity


cyclic nucleotide-dependent protein kinase activity

cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]


ATP:protein phosphotransferase (cAMP-dependent) activity

cAMP-dependent protein kinase, intrinsic catalyst activity

3',5'-cAMP-dependent protein kinase activity

3',5' cAMP-dependent protein kinase activity

cyclic AMP-dependent protein kinase activity

cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [EC:2.7.11.11]

adenosine 3',5'-cyclophosphate-dependent protein kinase activity


cyclic AMP-dependent protein kinase regulator activity

3',5'-cAMP-dependent protein kinase regulator activity

adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity

3',5' cAMP-dependent protein kinase regulator activity

Modulation of the activity of the enzyme cAMP-dependent protein kinase. [GOC:ai]


guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity

cGMP-dependent protein kinase ibeta activity

3':5'-cyclic GMP-dependent protein kinase activity

cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]

ATP:protein phosphotransferase (cGMP-dependent) activity


cyclin-dependent protein kinase activity

cyclin-dependent protein kinase, intrinsic catalyst activity

Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]

cyclin-dependent protein serine/threonine kinase activity


cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). [GOC:go_curators]

cyclin-dependent protein kinase activating kinase activity


cyclin-dependent protein kinase activating kinase, intrinsic regulator activity


cyclin-dependent protein kinase 5 activator activity


cyclin-dependent protein kinase regulator activity

cyclin-dependent protein serine/threonine kinase regulator activity

Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]


DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]


eukaryotic translation initiation factor 2alpha kinase activity

Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. [GOC:mah, InterPro:IPR015516]


ATP:IkappaB protein phosphotransferase activity

Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. [EC:2.7.11.10]


diacylglycerol-activated phospholipid-dependent protein kinase C activity

ATP:protein phosphotransferase (diacylglycerol-dependent) activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. [EC:2.7.11.13]

diacylglycerol-activated phospholipid-dependent PKC activity


conventional protein kinase C activity
calcium-dependent PKC activity

calcium-dependent protein kinase C activity

Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [EC:2.7.11.13, GOC:mah]


calcium-independent PKC activity
novel protein kinase C activity

calcium-independent protein kinase C activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. [EC:2.7.11.13, GOC:mah]


G-protein-coupled receptor phosphorylating protein kinase activity

GPCR phosphorylating protein kinase activity

G protein coupled receptor phosphorylating protein kinase activity

G-protein coupled receptor kinase activity

ATP:G-protein-coupled receptor phosphotransferase activity

Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate. [GOC:dph]

G protein-coupled receptor kinase activity


mitogen-activated protein kinase activity

ATP:protein phosphotransferase (MAPKK-activated) activity

Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. [GOC:ma, ISBN:0198547684]


ATP:protein phosphotransferase (MAPKKKK-activated) activity

mitogen-activated protein kinase kinase kinase activity

Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. [PMID:9561267]


Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). [GOC:bf]


MAP kinase kinase kinase kinase activity

Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. [GOC:bf, PMID:11790549]


Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK). [PMID:20685151]


Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. [GOC:bf, ISBN:0198506732]


Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. [GOC:mah, PMID:9822608]


5'-AMP-activated protein kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. [GOC:mah]


transmembrane receptor protein serine/threonine kinase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [EC:2.7.11.30]

receptor serine/threonine protein kinase activity


transforming growth factor beta receptor activity

transforming growth factor beta-activated receptor activity

Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:mah, GOC:signaling]


Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. [GOC:mah, GOC:signaling, ISBN:0198506732]


Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. [GOC:mah, PMID:8622651]


Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor. [GOC:mah, PMID:8622651]


type I transforming growth factor beta receptor activity

transforming growth factor beta receptor activity, type I

Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. [GOC:mah, Reactome:R-HSA-170846]


type II transforming growth factor beta receptor activity

transforming growth factor beta receptor activity, type II

Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. [GOC:mah, Reactome:R-HSA-170861]


RNA polymerase II carboxy-terminal domain kinase activity

RNA polymerase II CTD heptapeptide repeat kinase activity

Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. [EC:2.7.11.23, GOC:mah]


ATP:protein phosphotransferase (MAPKKK-activated) activity

mitogen-activated protein kinase kinase activity

Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. [ISBN:0198547684]


Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. [GOC:bf, PMID:11057897, PMID:11790549]


Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]


ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity

non-membrane spanning protein tyrosine kinase activity

Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]

non-specific protein-tyrosine kinase activity


OBSOLETE. (Was not defined before being made obsolete). [GOC:jid]


receptor protein-tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [EC:2.7.10.1, GOC:mah]


Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [GOC:jl, GOC:signaling]


Combining with an ephrin receptor ligand to initiate a change in cell activity. [GOC:mah, PMID:9530499]


Combining with a GPI-anchored ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]


Combining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]


epidermal growth factor-activated receptor activity

transforming growth factor-alpha receptor activity

epidermal growth factor receptor activity

Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:bf]


fibroblast growth factor receptor activity

fibroblast growth factor-activated receptor activity

Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]


granulocyte colony stimulating factor receptor activity

granulocyte colony-stimulating factor receptor activity

Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]


granulocyte macrophage colony-stimulating factor receptor activity

Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]

granulocyte macrophage colony stimulating factor receptor activity


hepatocyte growth factor-activated receptor activity

hepatocyte growth factor receptor activity

Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]


Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [ISBN:0198506732]


insulin-like growth factor receptor activity

insulin-like growth factor-activated receptor activity

Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]


macrophage colony stimulating factor receptor activity

Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [GOC:mah, GOC:signaling]

macrophage colony-stimulating factor receptor activity


OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]


platelet-derived growth factor receptor activity

Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]

platelet-derived growth factor-activated receptor activity


PDGF alpha-receptor activity
alphaPDGF receptor activity

platelet-derived growth factor alpha-receptor activity

Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. [PMID:1657917]


betaPDGF receptor activity
PDGF beta-receptor activity

platelet-derived growth factor beta-receptor activity

Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. [PMID:1657917]


KIT
SCF receptor activity
stem cell factor receptor activity
KIT ligand receptor activity

Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. [GOC:jl, GOC:signaling, PMID:10698217]


vascular endothelial growth factor E-activated receptor activity

vascular endothelial growth factor-activated receptor activity

vascular endothelial growth factor receptor activity

Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:19909239]


transmembrane receptor protein kinase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:mah]


Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. [EC:2.7.1.35]


pyruvate dehydrogenase (acetyl-transferring) kinase activity

pyruvate dehydrogenase kinase (phosphorylating) activity

Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. [EC:2.7.11.2]


FK
riboflavine kinase activity
riboflavin kinase (phosphorylating)
riboflavin kinase activity
flavokinase activity

Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). [EC:2.7.1.26, RHEA:14357]


Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. [EC:2.7.1.15]


ATP:selenide, water phosphotransferase activity

Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. [EC:2.7.9.3, RHEA:18737]


Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+). [EC:2.7.1.71, RHEA:13121]


Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. [EC:2.7.1.144]


Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a). [EC:2.7.1.130, RHEA:20700]


Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. [EC:2.7.6.2]


Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate. [EC:2.7.4.16, RHEA:15913]


C55-isoprenoid alcohol phosphokinase activity

Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate. [EC:2.7.1.66, RHEA:23752]

C55-isoprenyl alcohol phosphokinase activity


ATP:pyruvate, water phosphotransferase activity

Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate. [EC:2.7.9.2, RHEA:11364]


isocitrate dehydrogenase kinase activity

isocitrate dehydrogenase (NADP) kinase activity

[isocitrate dehydrogenase (NADP+)] kinase activity

isocitrate dehydrogenase kinase (phosphorylating) activity

isocitrate dehydrogenase (NADP+) kinase activity

Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate. [EC:2.7.11.5]

ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity


Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. [GOC:mah]


Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine. [GOC:bf, ISBN:0198506732, PMID:12957543]


Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol. [PMID:1572368, PMID:2061333]


ligase activity, forming carbon-carbon bonds

Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.4.-.-, GOC:jl, GOC:mah]


Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate. [UM-BBD_reactionID:r0033]


Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:mah]


acetyl coenzyme A carboxylase activity
acetyl-CoA carboxylase activity

Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. [EC:6.4.1.2]


propionyl coenzyme A carboxylase activity

Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. [EC:6.4.1.3]


Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate. [UM-BBD_reactionID:r0157]


Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. [EC:6.4.1.1, RHEA:20844]


ligase activity, forming carbon-nitrogen bonds

Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:mah]


Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]


Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. [GOC:jl]


Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine. [EC:6.3.1.1]


diphthamide synthase activity
diphthine:ammonia ligase (ADP-forming)
diphthamide synthetase activity

Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate. [EC:6.3.1.14, RHEA:19753]


L-glutamine synthetase activity
glutamylhydroxamic synthetase activity
glutamate-ammonia ligase activity
glutamine synthetase activity

Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate. [EC:6.3.1.2, RHEA:16169]


gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity

glutathione:spermidine ligase (ADP-forming) activity

Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate. [EC:6.3.1.8]


Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]


Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate. [EC:2.7.7.58, RHEA:20229]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


alanine:alanine ligase (ADP-forming) activity

Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate. [EC:6.3.2.4, RHEA:11224]


dihydrofolate synthetase-folylpolyglutamate synthetase activity

7,8-dihydropteroate:L-glutamate ligase (ADP) activity

dihydropteroate:L-glutamate ligase (ADP-forming) activity

folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity

Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate. [EC:6.3.2.12]


tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity

folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity

folate polyglutamate synthetase activity

Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). [EC:6.3.2.17]


L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity

Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. [EC:6.3.2.2, RHEA:13285]


Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate. [EC:6.3.2.3, RHEA:13557]


Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. [EC:6.3.2.1]


Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. [EC:6.3.2.5]


ribosomal S6-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6. [GOC:mah, PMID:2570347]


Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. [EC:6.3.2.25]


E3
ubiquitin-like-protein ligase activity
ubiquitin-like protein ligase activity

Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]

small conjugating protein ligase activity


ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition

Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]


uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity

Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. [EC:6.3.2.9, RHEA:16429]


UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity

Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate. [EC:6.3.2.13, RHEA:23676]


Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. [RHEA:28374]


carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)

carbamoyl-phosphate synthetase (ammonia) activity

carbamoyl-phosphate synthetase I activity

carbamoylphosphate synthetase (ammonia) activity

carbamoyl phosphate synthase (ammonia) activity

carbamoyl-phosphate synthase (ammonia) activity

Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate. [EC:6.3.4.16, RHEA:10624]


carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity

carbamyl phosphate synthetase (glutamine) activity

carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity

carbamoyl-phosphate synthase (glutamine-hydrolysing) activity

glutamine-dependent carbamoyl-phosphate synthase activity

carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity

glutamine-dependent carbamyl phosphate synthetase activity

hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

carbamoylphosphate synthetase II activity

Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. [EC:6.3.5.5, RHEA:18633]

carbamoyl phosphate synthase (glutamine-hydrolyzing) activity


Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen. [PMID:12360532]

carbon-nitrogen ligase activity, with glutamine as amido-N-donor


asparagine synthase (glutamine-hydrolyzing) activity

asparagine synthetase (glutamine-hydrolyzing) activity

glutamine-dependent asparagine synthetase activity

Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. [EC:6.3.5.4, RHEA:12228]


glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]


guanosine 5'-monophosphate synthetase activity

GMP synthetase (glutamine-hydrolyzing) activity

xanthosine 5'-phosphate amidotransferase activity

guanosine monophosphate synthetase (glutamine-hydrolyzing)

Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+). [RHEA:11680]

GMP synthase (glutamine-hydrolyzing) activity


NAD(+) synthetase (glutamine-hydrolyzing) activity

desamidonicotinamide adenine dinucleotide amidotransferase activity

NAD synthase (glutamine-hydrolyzing) activity

NAD+ synthase (glutamine-hydrolyzing) activity

nicotinamide adenine dinucleotide synthetase (glutamine) activity

Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. [EC:6.3.5.1]


formylglycinamide ribotide amidotransferase activity

formylglycinamide ribonucloetide amidotransferase activity

Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. [EC:6.3.5.3, RHEA:17129]


Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]


Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate. [EC:6.3.3.2, RHEA:10488]


Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate. [EC:6.3.3.3, RHEA:15805]


5'-aminoimidazole ribonucleotide synthetase activity

Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. [EC:6.3.3.1, RHEA:23032]


Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP. [PMID:16141198, PMID:17570395, RHEA:49288]


protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity

protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity

Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. [EC:2.8.1.8, PMID:18307109]


OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized. [GOC:ai]


adenylosuccinate synthetase activity
succinoadenylic kinosynthetase activity
adenylosuccinate synthase activity
IMP--aspartate ligase activity
IMP:L-aspartate ligase (GDP-forming)

Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. [EC:6.3.4.4, RHEA:15753]


argininosuccinic acid synthetase activity

Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. [EC:6.3.4.5]


biotin carboxylase (component of acetyl CoA carboxylase) activity

Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. [EC:6.3.4.14]

biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity


biotin-apoprotein ligase activity
biotin--protein ligase activity

Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein. [GOC:mah]


acetyl CoA holocarboxylase synthetase activity

biotin-acetyl coenzyme A carboxylase synthetase activity

acetyl-CoA carboxylase biotin holoenzyme synthetase activity

acetyl coenzyme A holocarboxylase synthetase activity

biotin--[acetyl-CoA carboxylase] synthetase activity

biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)

Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)). [EC:6.3.4.15]


biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity

propionyl-CoA holocarboxylase synthetase activity

biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity

biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)

biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity

propionyl coenzyme A holocarboxylase synthetase activity

biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity

biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)

biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity

biotin-propionyl coenzyme A carboxylase synthetase activity

Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)). [EC:6.3.4.11]

beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity


biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)

methylmalonyl coenzyme A holotranscarboxylase synthetase activity

biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)

Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). [EC:6.3.4.9]

biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity


cytidine 5'-triphosphate synthetase activity

cytidine triphosphate synthetase activity

Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. [PMID:12354108, RHEA:26426]


Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. [EC:6.3.4.3]


Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+). [RHEA:18301]


glycineamide ribonucleotide synthetase activity

glycinamide ribonucleotide synthetase activity

Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. [EC:6.3.4.13, RHEA:17453]

2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity


Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate. [EC:6.3.4.6, RHEA:20896]


Increases the activity of urease by promoting the incorporation of nickel into the active site. [GOC:mah, PMID:16244137]


ligase activity, forming carbon-oxygen bonds

Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.1.-.-, GOC:mah]


alanine transfer RNA synthetase activity

alanyl-transfer ribonucleic acid synthetase activity

alanyl-transfer ribonucleate synthetase activity

alanyl-transfer ribonucleate synthase activity

Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). [EC:6.1.1.7]


aminoacyl-tRNA synthetase auxiliary protein activity


arginyl-transfer RNA synthetase activity

arginyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). [EC:6.1.1.19]

arginyl transfer ribonucleic acid synthetase activity


asparagyl-transfer RNA synthetase activity

asparaginyl transfer RNA synthetase activity

asparaginyl-transfer ribonucleate synthetase activity

asparaginyl transfer ribonucleic acid synthetase activity

Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+). [EC:6.1.1.22, RHEA:11180]


aspartyl-transfer ribonucleic acid synthetase activity

aspartyl ribonucleic synthetase activity

aspartyl-transfer RNA synthetase activity

Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). [EC:6.1.1.12]

aspartyl ribonucleate synthetase activity


cysteinyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). [EC:6.1.1.16]


glutamyl-transfer ribonucleic acid synthetase activity

L-glutamate:tRNAGlu ligase (AMP-forming) activity

glutamyl-transfer RNA synthetase activity

glutamyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). [EC:6.1.1.17]


glutaminyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). [EC:6.1.1.18]

glutaminyl-transfer RNA synthetase activity


glycyl-transfer ribonucleate synthetase activity

glycine:tRNAGly ligase (AMP-forming) activity

glycyl-transfer ribonucleic acid synthetase activity

Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). [EC:6.1.1.14]


histidyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). [EC:6.1.1.21]


isoleucyl-transfer RNA synthetase activity

Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). [EC:6.1.1.5, RHEA:11060]

isoleucyl-transfer ribonucleate synthetase activity


leucyl-transfer ribonucleic acid synthetase activity

leucyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). [EC:6.1.1.4, RHEA:11688]


lysine translase activity
L-lysine:tRNALys ligase (AMP-forming)
lysine-tRNA synthetase activity
lysyl-transfer RNA synthetase activity
L-lysine-transfer RNA ligase activity
lysine-tRNA ligase activity
lysyl-tRNA synthetase activity

Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). [EC:6.1.1.6]

lysyl-transfer ribonucleate synthetase activity


methionyl-transfer ribonucleate synthetase activity

methionyl-transfer RNA synthetase activity

methionyl-transfer ribonucleic acid synthetase activity

Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). [EC:6.1.1.10]


phenylalanyl-transfer RNA synthetase activity

phenylalanyl-transfer RNA ligase activity

phenylalanyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). [EC:6.1.1.20]

L-phenylalanine:tRNAPhe ligase (AMP-forming) activity


prolyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). [EC:6.1.1.15]

prolyl-transfer ribonucleic acid synthetase activity


seryl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). [EC:6.1.1.11]

seryl-transfer ribonucleic acid synthetase activity


threonyl-transfer RNA synthetase activity

threonyl ribonucleic synthetase activity

threonine-transfer ribonucleate synthetase activity

threonyl-transfer ribonucleic acid synthetase activity

threonyl-transfer ribonucleate synthetase activity

Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). [EC:6.1.1.3]


tryptophanyl ribonucleic synthetase activity

L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity

tryptophanyl-transfer ribonucleic synthetase activity

tryptophanyl-transfer ribonucleic acid synthetase activity

tryptophanyl-transfer ribonucleate synthetase activity

tryptophanyl-transfer RNA synthetase activity

Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). [EC:6.1.1.2]


tyrosyl-transfer ribonucleic acid synthetase activity

tyrosyl-transfer ribonucleate synthetase activity

tyrosyl-transfer RNA synthetase activity

L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity

tyrosine-transfer ribonucleate synthetase activity

Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). [EC:6.1.1.1, RHEA:10220]


valyl-transfer ribonucleic acid synthetase activity

valyl-transfer ribonucleate synthetase activity

valine transfer ribonucleate ligase activity

Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). [EC:6.1.1.9, RHEA:10704]


ligase activity, forming carbon-sulphur bonds

ligase activity, forming carbon-sulfur bonds

Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.-.-, GOC:mah]


Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.1.-, GOC:mah]


Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA. [EC:6.2.1.14, RHEA:14781]


Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. [GOC:ai]


Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA. [UM-BBD_reactionID:r0137]


Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA. [UM-BBD_reactionID:r0429]


Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. [UM-BBD_reactionID:r0737]


Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway. [EC:6.2.1.33]


hydroxycinnamoyl CoA synthetase activity

p-hydroxycinnamic acid:CoA ligase activity

caffeolyl coenzyme A synthetase activity

p-coumaryl coenzyme A synthetase activity

p-hydroxycinnamoyl coenzyme A synthetase activity

Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA. [EC:6.2.1.12]


4-hydroxybenzoate-coenzyme A ligase (AMP-forming)

4-hydroxybenzoyl coenzyme A synthetase activity

Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA. [EC:6.2.1.27]


short chain fatty acyl-CoA synthetase activity

short-chain acyl-coenzyme A synthetase activity

Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. [EC:6.2.1.1]


anthraniloyl coenzyme A synthetase activity

2-aminobenzoate-coenzyme A ligase activity

2-aminobenzoate coenzyme A ligase activity

Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA. [EC:6.2.1.32]


benzoyl CoA synthetase (AMP forming)
benzoate-coenzyme A ligase activity
benzoyl-coenzyme A synthetase activity
benzoate-CoA ligase activity

Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate. [EC:6.2.1.25, RHEA:10132]


Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA. [UM-BBD_reactionID:r0242]


o-succinylbenzoyl-coenzyme A synthetase activity

Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate. [EC:6.2.1.26]


OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA. [UM-BBD_reactionID:r0731]


Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. [GOC:ai]


succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity

succinate-CoA ligase (ADP-forming) activity

Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. [PMID:9874242, RHEA:17661]

succinyl-CoA synthetase (ADP-forming) activity


succinyl-CoA synthetase (GDP-forming) activity

succinate:CoA ligase (GDP-forming) activity

succinate-CoA ligase (GDP-forming) activity

succinyl coenzyme A synthetase (GDP-forming) activity

Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. [RHEA:22120]

succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity


long-chain fatty acid-CoA ligase activity

fatty acid thiokinase (long-chain) activity

long-chain fatty acyl coenzyme A synthetase activity

long-chain acyl-coenzyme A synthetase activity

Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [RHEA:15421]

long chain fatty acyl-CoA synthetase activity


acetate: SH-acyl-carrier-protein enzyme ligase (AMP)

acetate:HS-citrate lyase ligase activity

Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form). [EC:6.2.1.22]

[citrate (pro-3S)-lyase] ligase activity


ligase activity, forming phosphoric ester bonds

Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.5.-.-, GOC:mah]


Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. [ISBN:0716720094]


polydeoxyribonucleotide synthase (ATP) activity

Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). [EC:6.5.1.1]


Polydeoxyribonucleotide synthase (NAD(+)) activity

poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)

polynucleotide ligase (nicotinamide adenine dinucleotide)

polynucleotide synthetase (nicotinamide adenine dinucleotide)

Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). [EC:6.5.1.2]

polydeoxyribonucleotide synthase (NAD+) activity


Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another. [GOC:mah]


Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. [GOC:mah, PMID:8940112]


polyribonucleotide synthase (ATP) activity

Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). [EC:6.5.1.3]


RNA 3'-terminal phosphate cyclase activity

Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. [EC:6.5.1.4]

RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)


Catalysis of the reaction: Lipid A-core + colanic acid = MLPS. [MetaCyc:RXN0-5294]


Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [ISBN:0198547684]


Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]


Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. [GOC:curators]


Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. [EC:4.1.2.20]


2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity

2-oxo-3-deoxygalactonate 6-phosphate aldolase activity

Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate. [EC:4.1.2.21, RHEA:24464]


Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. [EC:4.1.2.14]


7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity

2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity

3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity

3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity

7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity

Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. [EC:2.5.1.54, RHEA:14717]


2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity

3-deoxyoctulosonic 8-phosphate synthetase activity

3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity

Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate. [EC:2.5.1.55, RHEA:14053]


Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. [EC:4.1.2.4, RHEA:12821]


Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. [EC:4.1.2.25]


fructose 1,6-diphosphate aldolase activity

fructose 1-monophosphate aldolase activity

Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate. [EC:4.1.2.13]


L-fuculose 1-phosphate aldolase activity

Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate. [EC:4.1.2.17, RHEA:12933]


Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. [EC:4.1.2.19]

L-rhamnulose 1-phosphate aldolase activity


dihydrosphingosine 1-phosphate aldolase activity

Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. [EC:4.1.2.27]


tagatose 1,6-diphosphate aldolase activity

D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)

D-tagatose-1,6-bisphosphate triosephosphate lyase activity

Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate. [EC:4.1.2.40, RHEA:22948]


L-threonine acetaldehyde-lyase activity
L-threonine aldolase activity
threonine aldolase activity

Catalysis of the reaction: L-threonine = glycine + acetaldehyde. [EC:4.1.2.5]


Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde. [PMID:9228760, RHEA:26209]


Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. [EC:4.1.3.16]


Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. [GOC:curators]


Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. [PMID:8529896]


Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate. [UM-BBD_reactionID:r0621]


Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate. [UM-BBD_reactionID:r0398]


Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol. [UM-BBD_reactionID:r0617]


Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde. [EC:4.1.1.71, RHEA:10524]


Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol. [UM-BBD_reactionID:r0546]


polyprenyl p-hydroxybenzoate decarboxylase activity

3-polyprenyl 4-hydroxybenzoate decarboxylase activity

Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2. [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN]


Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. [EC:4.1.1.55]


Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol. [EC:4.1.1.61, RHEA:10876]


Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. [EC:4.1.1.68]


Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2). [EC:4.1.1.50, RHEA:15981]

adenosyl methionine decarboxylase activity


Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2). [EC:4.1.1.19, RHEA:17641]


Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. [GOC:bf, GOC:PARL, RHEA:12272]


Catalysis of the reaction: L-aspartate = beta-alanine + CO2. [EC:4.1.1.11]


Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM. [UM-BBD_reactionID:r0520]


Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2). [EC:4.1.1.20, RHEA:15101]

diaminopimelic acid decarboxylase activity


mevalonate 5-diphosphate decarboxylase activity

ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)

mevalonate diphosphate decarboxylase activity

pyrophosphomevalonic acid decarboxylase activity

Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate. [EC:4.1.1.33, RHEA:23732]

mevalonate pyrophosphate decarboxylase activity


Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol. [EC:4.1.1.59, RHEA:12749]


Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. [PMID:18374194]


glutaconyl coenzyme A decarboxylase activity

Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2). [PMID:11248185, RHEA:23972]


Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. [EC:4.1.1.15]


Catalysis of the reaction: L-histidine = histamine + CO2. [EC:4.1.1.22]


indoleglycerol phosphate synthetase activity

indoleglycerol phosphate synthase activity

Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. [EC:4.1.1.48]


Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2). [EC:4.1.1.18, RHEA:22352]


methylmalonyl-coenzyme A decarboxylase activity

Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2. [EC:7.2.4.3]


Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. [EC:4.1.1.17, RHEA:22964]


uridine 5'-monophosphate synthase activity

orotidine monophosphate decarboxylase activity

orotidine 5'-phosphate decarboxylase activity

orotidine phosphate decarboxylase activity

orotate monophosphate decarboxylase activity

Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. [EC:4.1.1.23, RHEA:11596]


oxalate carboxy-lyase activity
oxalate carboxy-lyase (formate-forming)

Catalysis of the reaction: H(+) + oxalate = CO(2) + formate. [EC:4.1.1.2, RHEA:16509]


Catalysis of the reaction: oxaloacetate = pyruvate + CO2. [EC:1.1.1.38, EC:1.1.1.40, EC:4.1.1.112]


oxalyl coenzyme A decarboxylase activity

Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA. [EC:4.1.1.8, RHEA:19333]


Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. [EC:4.1.1.65, RHEA:20828]


Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate. [EC:4.1.1.36, RHEA:16793]


5-amino-1-ribosylimidazole 5-phosphate carboxylase activity

Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). [EC:4.1.1.21, RHEA:10792]


Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2. [EC:4.1.1.1]


ribulose diphosphate carboxylase activity

ribulose diphosphate carboxylase/oxygenase activity

ribulose 1,5-bisphosphate carboxylase/oxygenase activity

D-ribulose 1,5-diphosphate carboxylase activity

ribulose 1,5-diphosphate carboxylase/oxygenase activity

ribulose bisphosphate carboxylase/oxygenase activity

ribulose 1,5-bisphosphate carboxylase activity

Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O. [RHEA:23124]


L-cysteinesulfinic acid decarboxylase activity

Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. [EC:4.1.1.29]


tartronic semialdehyde carboxylase activity

tartronate semialdehyde carboxylase activity

hydroxymalonic semialdehyde carboxylase activity

Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2). [EC:4.1.1.47, RHEA:10136]

glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)


Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate. [EC:4.1.2.34]


Catalysis of the reaction: L-tyrosine = tyramine + CO2. [EC:4.1.1.25]


uroporphyrinogen III decarboxylase activity

Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. [EC:4.1.1.37]


OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized. [GOC:ai]


1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity

1-aminocyclopropane carboxylic acid deaminase activity

Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+). [EC:3.5.99.7, RHEA:16933]


Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO. [GOC:kad, PMID:6593720, PMID:8718622]


Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate. [EC:4.1.99.11, RHEA:10416]


Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. [GOC:mah, PMID:11124949]


Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. [GOC:mah, PMID:11124949]


L-tryptophan indole-lyase (deaminating; pyruvate forming) activity

tryptophan catabolism, using tryptophanase

tryptophan catabolic process, using tryptophanase

Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate. [RHEA:19553]

L-tryptophan indole-lyase (deaminating) activity


oxo-acid lyase activity
oxoacid lyase activity

Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. [EC:4.1.3.-, GOC:jl]


1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity

Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2). [EC:2.2.1.7, RHEA:12605]


2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity

propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)

Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+). [RHEA:19185]


3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity

acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)

Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+). [RHEA:21524]


2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity

Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate. [EC:4.2.99.20, RHEA:25597]


acetolactate pyruvate-lyase (carboxylating) activity

alpha-acetohydroxy acid synthetase activity

Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. [RHEA:25249]


chorismate pyruvate-lyase (amino-accepting) activity

Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. [EC:4.1.3.27]


ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity

adenosine triphosphate citrate lyase activity

acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)

acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity

Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA. [RHEA:21160]


chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity

Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate. [EC:4.1.3.40, RHEA:16505]


citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity

citrate oxaloacetate-lyase, CoA-acetylating activity

Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. [EC:2.3.3.1]


citrate aldolase activity
citric aldolase activity
citratase activity
citridesmolase activity
citrate (pro-3S)-lyase activity
citrate lyase
citritase activity
citrate oxaloacetate-lyase activity
citrate lyase activity

Catalysis of the reaction: citrate = acetate + oxaloacetate. [RHEA:10760]


Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. [EC:4.1.3.34]


acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity

2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity

Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [RHEA:12929]

acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)


3-hydroxy-3-methylglutaryl coenzyme A lyase activity

Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. [EC:4.1.3.4, RHEA:24404]

hydroxymethylglutaryl coenzyme A lyase activity


3-hydroxy-3-methylglutaryl coenzyme A synthetase activity

hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity

3-hydroxy-3-methylglutaryl coenzyme A synthase activity

3-hydroxy-3-methylglutaryl CoA synthetase activity

acetoacetyl coenzyme A transacetase activity

(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity

hydroxymethylglutaryl coenzyme A synthase activity

3-hydroxy-3-methylglutaryl-coenzyme A synthase activity

Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). [RHEA:10188]

acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)


Catalysis of the reaction: isocitrate = glyoxylate + succinate. [EC:4.1.3.1, RHEA:13245]


L-malate glyoxylate-lyase (CoA-acetylating) activity

acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)

Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+). [RHEA:18181]


Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. [EC:4.1.3.30, RHEA:16809]


N-acetylneuraminic acid aldolase activity

Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. [EC:4.1.3.3, RHEA:23296]


Catalysis of the breakage of a bond between carbon and any halogen atom. [GOC:mah]


Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. [UM-BBD_reactionID:r0513]


Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU. [UM-BBD_reactionID:r0515]


3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)

Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3. [EC:4.5.1.2]


Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone. [UM-BBD_reactionID:r0666]


Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+). [EC:4.5.1.1, RHEA:19217]


dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)

Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+). [EC:4.5.1.3, RHEA:15397]


Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene. [UM-BBD_enzymeID:e0359]


Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide. [PMID:8017917]


halohydrin hydrogen-halide-lyase A activity

Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane. [UM-BBD_enzymeID:e0048]


halohydrin hydrogen-halide-lyase B activity

Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane. [UM-BBD_enzymeID:e0050]


Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). [EC:4.3.-.-]


Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. [EC:4.3.-.-, GOC:krc]


N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. [EC:4.3.2.2]


Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. [EC:4.3.2.1]


alpha-hydroxyglycine amidating dealkylase activity

peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity

Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. [EC:4.3.2.5]


Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate. [EC:4.3.-.-, GOC:krc]


Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol. [EC:5.4.4.1, UM-BBD_reactionID:r0304]


Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine. [EC:4.3.3.2, RHEA:15013]


Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde. [UM-BBD_enzymeID:e0421]


Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. [EC:4.3.-.-, GOC:krc]


Catalysis of the reaction: L-aspartate = fumarate + NH3. [EC:4.3.1.1]


D-serine dehydratase (deaminating) activity

D-hydroxy amino acid dehydratase activity

Catalysis of the reaction: D-serine = pyruvate + NH3. [EC:4.3.1.18]

D-serine hydro-lyase (deaminating) activity


2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)

Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3. [EC:4.3.1.15]


ethanolamine ammonia-lyase activity
ethanolamine deaminase activity

Catalysis of the reaction: ethanolamine = acetaldehyde + NH3. [EC:4.3.1.7]

ethanolamine ammonia-lyase (acetaldehyde-forming) activity


5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)

Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+). [EC:4.3.1.4, RHEA:22736]


Catalysis of the reaction: L-histidine = urocanate + NH3. [EC:4.3.1.3]


Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). [EC:2.5.1.61, RHEA:13185]


L-serine ammonia-lyase (pyruvate-forming) activity

L-serine hydro-lyase (deaminating) activity

Catalysis of the reaction: L-serine = pyruvate + NH3. [EC:4.3.1.17]


ornithine cyclase (deaminating) activity

L-ornithine ammonia-lyase (cyclizing; L-proline-forming)

Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+). [EC:4.3.1.12, RHEA:24368]


PAL activity
phenylalanine ammonia-lyase activity
phenylalanine deaminase activity
phenylalanine ammonium-lyase activity
phe ammonia-lyase activity

Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. [RHEA:21384]


OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases. [GOC:krc]


cyanate lyase activity
cyanate aminohydrolase activity
cyanate hydrolase activity
cyanate hydratase activity
carbamate hydro-lyase activity
cyanate C-N-lyase activity

Catalysis of the reaction: cyanate + H2O = carbamate. [EC:4.2.1.104, RHEA:11120]


Catalysis of the breakage of a carbon-oxygen bond. [EC:4.2.-.-]


carbon-oxygen lyase activity, acting on phosphates

Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. [EC:4.2.3.-]


Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate. [EC:4.2.3.4, RHEA:21968]


2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity

Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate. [EC:4.2.3.12, RHEA:22048]

6-pyruvoyl tetrahydrobiopterin synthase activity


2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)

trans,trans-farnesyl diphosphate aristolochene-lyase activity

Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate. [EC:4.2.3.9]

trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)


Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. [EC:4.2.3.5, RHEA:21020]


ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)

Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate. [EC:4.2.3.19, RHEA:22220]


Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate. [EC:4.2.3.3, RHEA:17937]


O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)

O-phospho-L-homoserine phospho-lyase (adding water)

Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. [EC:4.2.3.1]


trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)

Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene. [EC:4.2.3.6, RHEA:12052]


carbon-oxygen lyase activity, acting on polysaccharides

Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide. [EC:4.2.-.-]


chondroitin lyase activity
chondroitin AC lyase activity
ChnAC
chondroitin AC eliminase activity
chondroitinase activity

Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. [EC:4.2.2.5]


heparitin-sulfate lyase activity
heparin-sulfate lyase activity

Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. [EC:4.2.2.8]


hyaluronate lyase activity
mucinase activity

Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. [EC:4.2.2.1]


polygalacturonic acid trans-eliminase activity

endo-alpha-1,4-polygalacturonic acid lyase activity

alpha-1,4-D-endopolygalacturonic acid lyase activity

Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. [EC:4.2.2.2]


alginase activity
poly(beta-D-mannuronate) lyase activity
alginate lyase activity

Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. [EC:4.2.2.3]


rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity

Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue. [PMID:8587995, PMID:8720076]


Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. [EC:4.2.1.-]


(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity

Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O. [EC:4.2.1.59, GOC:ai, PMID:12368867, RHEA:41892]


Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate. [UM-BBD_reactionID:r0618]


2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity

Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. [UM-BBD_reactionID:r0369]


Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. [EC:4.2.1.80]


Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O. [EC:4.2.1.10, RHEA:21096]


Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. [EC:4.2.1.118, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN]


3-hydroxyacyl-[acyl-carrier protein] dehydratase activity

Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]. [MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN]


Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). [UM-BBD_ruleID:bt0291]


D-3-hydroxybutyryl coenzyme A dehydratase activity

Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O. [EC:4.2.1.55, RHEA:17849]


3-hydroxydecanoyl-acyl carrier protein dehydrase activity

3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity

beta-hydroxydecanoyl thiol ester dehydrase activity

beta-hydroxydecanoyl thioester dehydrase activity

beta-hydroxyacyl-acyl carrier protein dehydratase activity

3-hydroxydecanoyl-acyl carrier protein dehydratase activity

Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. [EC:4.2.1.59, PMID:8910376, RHEA:41860]


beta-hydroxypalmitoyl thioester dehydratase activity

beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity

(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)

3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity

Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. [PMID:8088535, RHEA:41908]


Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. [EC:4.2.1.33]


Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine. [MetaCyc:RXN-645, UM-BBD_reactionID:r0051]


Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O. [EC:4.2.1.96, RHEA:11920]


methylthioribulose 1-phosphate dehydratase activity

Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O. [EC:4.2.1.109, RHEA:15549]


Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA. [UM-BBD_reactionID:r0204]


acetylene hydratase activity
acetaldehyde hydro-lyase activity
AHy

Catalysis of the reaction: acetaldehyde = acetylene + H(2)O. [EC:4.2.1.112, RHEA:17885]


Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. [EC:4.2.1.3, GOC:pde, GOC:vw]


Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. [EC:4.2.1.7, RHEA:15957]


Catalysis of the reaction: H2CO3 = CO2 + H2O. [EC:4.2.1.1]


urea hydro-lyase activity
cyanamide hydratase activity

Catalysis of the reaction: urea = cyanamide + H(2)O. [EC:4.2.1.69, RHEA:23056]


formamide dehydratase activity
formamide hydro-lyase activity
cyanide hydratase activity

Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide. [EC:4.2.1.66, RHEA:21720]


Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA. [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191]


Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA. [EC:4.2.1.100, RHEA:21856]


L-serine hydro-lyase (adding homocysteine)

L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)

Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. [EC:4.2.1.22]


L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)

dihydrodipicolinic acid synthase activity

Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O. [PMID:8993314, RHEA:34171]


Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. [EC:4.2.1.9]


thymidine diphosphoglucose oxidoreductase activity

Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. [EC:4.2.1.46, RHEA:17221]


Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA. [UM-BBD_reactionID:r0331]


short-chain enoyl-CoA hydratase activity

short chain enoyl coenzyme A hydratase activity

Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. [EC:4.2.1.17]


long-chain enoyl coenzyme A hydratase activity

Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. [EC:4.2.1.74]


Catalysis of the reaction: (S)-malate = fumarate + H(2)O. [EC:4.2.1.2, RHEA:12460]


Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. [EC:4.2.1.42, RHEA:16005]


Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O. [EC:4.2.1.6, RHEA:18649]


guanosine 5'-diphosphate-D-mannose oxidoreductase activity

guanosine diphosphomannose oxidoreductase activity

guanosine diphosphomannose 4,6-dehydratase activity

Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. [EC:4.2.1.47, RHEA:23820]


glucarate dehydratase activity
D-glucarate dehydratase activity
D-glucarate hydro-lyase activity

Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. [EC:4.2.1.40]


glycerol dehydrase activity
glycerol hydro-lyase activity
glycerol dehydratase activity

Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. [EC:4.2.1.30, PMID:18307109]


Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O. [EC:4.2.1.36, RHEA:15485]


D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity

imidazoleglycerol phosphate dehydratase activity

Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. [EC:4.2.1.19, RHEA:11040]


gluconate 6-phosphate dehydratase activity

Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O. [EC:4.2.1.12, RHEA:17277]


L-(+)-tartaric acid dehydratase activity

Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate. [EC:4.2.1.32, RHEA:15413]


L-carnitine dehydratase activity
carnitine dehydratase activity

Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O. [EC:4.2.1.89, RHEA:14577]


Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O. [EC:4.2.1.54, RHEA:34691]


Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. [EC:4.2.1.8, RHEA:20097]


methylglutaconyl coenzyme A hydratase activity

3-methylglutaconyl CoA hydratase activity

Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O. [EC:4.2.1.18, RHEA:21536]


Catalysis of the reaction: an aliphatic amide = a nitrile + H2O. [RHEA:12673]


Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile. [EC:4.99.1.7, RHEA:20069]

(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity


Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. [EC:4.2.1.11, ISBN:0198506732]


delta-aminolevulinic acid dehydratase activity

5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)

delta-aminolevulinic acid dehydrase activity

Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. [EC:4.2.1.24, RHEA:24064]

5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)


prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)

Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. [EC:4.2.1.51]


pseudouridine monophosphate synthetase activity

5-ribosyluracil 5-phosphate synthetase activity

uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)

uracil hydro-lyase (adding D-ribose 5-phosphate)

Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate. [EC:4.2.1.70, RHEA:18337]

pseudouridine monophosphate synthase activity


Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol. [PMID:9857081]


scytalone 7,8-hydro-lyase activity
scytalone dehydratase activity

Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O. [EC:4.2.1.94, RHEA:24396]


L-threonine hydro-lyase (deaminating) activity

Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. [EC:4.3.1.19]


Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene. [UM-BBD_reactionID:r0164]


Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde). [UM-BBD_enzymeID:e0257]


indoleglycerol phosphate aldolase activity

L-serine hydro-lyase (adding indoleglycerol-phosphate)

Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. [RHEA:10532]


Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O. [EC:4.2.1.49, RHEA:13101]


uroporphyrinogen III cosynthase activity

hydroxymethylbilane hydro-lyase (cyclizing) activity

hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)

Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III. [EC:4.2.1.75, RHEA:18965]


OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases. [GOC:krc]


O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity

O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)

Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. [EC:2.5.1.47]


L-methionine anabolism, direct, from O-acetyl-L-homoserine

L-methionine formation, direct, from O-acetyl-L-homoserine

O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity

L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine

Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers. [EC:2.5.1.49]

L-methionine synthesis, direct, from O-acetyl-L-homoserine


O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity

Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. [EC:2.5.1.48]


Catalysis of the elimination of hydrogen sulfide or substituted H2S. [EC:4.4.-.-]


1-aminocyclopropane-1-carboxylic acid synthase activity

aminocyclopropanecarboxylic acid synthase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+). [EC:4.4.1.14, RHEA:21744]


Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. [EC:4.4.1.8]

L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)


cysteine desulfurylase activity
cysteine desulfurase activity
NIFS
SufS
IscS

Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. [EC:2.8.1.7]

L-cysteine:enzyme cysteine sulfurtransferase activity


L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)

Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. [RHEA:14005]


D-cysteine sulfide-lyase (deaminating; pyruvate-forming)

Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate. [EC:4.4.1.15]


Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite. [RHEA:28278]

cysteine sulphinate desulphinase activity


Catalysis of the reaction: holocytochrome c = apocytochrome c + heme. [EC:4.4.1.17]


(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity

(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)

Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. [EC:4.4.1.5, RHEA:19069]


L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)

Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate. [EC:4.4.1.11, RHEA:23800]


Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor. [EC:4.4.1.16]


OBSOLETE. A grouping term for lyases that cannot be more accurately categorized. [GOC:ai]


alkylmercury mercuric-lyase activity
organomercurial lyase activity
organomercury lyase activity
alkylmercury lyase activity

Catalysis of the reaction: an alkylmercury + H+ = an alkane + Hg2+. [RHEA:18777]


Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate). [PMID:3804975]


Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX. [RHEA:22584]


Mg-protoporphyrin IX magnesium-lyase activity

magnesium-protoporphyrin IX chelatase activity

protoporphyrin IX magnesium-chelatase activity

Mg-protoporphyrin IX magnesio-lyase activity

Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate. [EC:6.6.1.1, RHEA:13961]


Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]


ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity

ATP diphosphate-lyase (cyclizing) activity

Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [EC:4.6.1.1]


calcium- and calmodulin-responsive adenylyl cyclase activity

calcium/calmodulin-responsive adenylate cyclase activity

calcium- and calmodulin-responsive adenylate cyclase activity

Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin. [EC:4.6.1.1, GOC:mah]


GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity

Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2]

GTP diphosphate-lyase (cyclizing) activity


OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2]