Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin. [EC:4.3.3.4, RHEA:12296]


Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin. [EC:4.3.3.3, RHEA:21756]


Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH(4)(+). [EC:4.3.1.14, RHEA:10056]


beta-alanyl coenzyme A ammonia-lyase activity

Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3. [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN]


O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)

Catalysis of the reaction: O-carbamoyl-L-serine + H(2)O + H(+) = CO(2) + 2 NH(4)(+) + pyruvate. [EC:4.3.1.13, RHEA:15445]


erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity

Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid. [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN]


acetylenemonocarboxylic acid hydrase activity

2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity

D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)

Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3. [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN]


Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+). [EC:4.3.1.2, RHEA:12829]


Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate. [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN]


Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate. [EC:4.3.1.16, RHEA:12424]


2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)

Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene. [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN]


geranyl pyrophosphate:(-)-endo-fenchol cyclase activity

Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate. [EC:4.2.3.10, RHEA:20565]


geranyldiphosphate diphosphate lyase (limonene forming)

Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate. [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN]


(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)

Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate. [EC:4.2.3.18, RHEA:13873]


geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)

Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate. [EC:4.2.3.8, RHEA:14901]


ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)

Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate. [EC:4.2.3.2, RHEA:17889]


geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity

Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene. [EC:4.2.3.15, RHEA:16965]


2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)

2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)

Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene. [EC:4.2.3.7, RHEA:18081]


geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)

Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate. [EC:4.2.3.11, RHEA:19565]


geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)

geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)

Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene. [EC:4.2.3.17, RHEA:20912]


Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. [GOC:hjd]


alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity

alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity

Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose. [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN]


Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends. [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN]


unsaturated oligogalacturonate transeliminase activity

Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate. [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN]


Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin. [EC:4.2.2.9]


Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends. [EC:4.2.2.10]


polyguluronate-specific alginate lyase activity

Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends. [EC:4.2.2.11]


Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain. [EC:4.2.2.12]


Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H(2)O. [EC:4.2.1.35, RHEA:22332]


Catalysis of the reaction: S-citramalate = H(2)O + mesaconate. [EC:4.2.1.34, RHEA:13529]


4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)

Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O. [EC:4.2.1.78]


Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone. [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN]


Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O. [EC:4.2.1.43, RHEA:17201]


Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O. [EC:4.2.1.79, RHEA:17725]


Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O. [EC:4.2.1.99, RHEA:17941]


Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+). [EC:4.2.1.65, RHEA:15385]


3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity

(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)

beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity

D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity

beta-hydroxyoctanoyl thioester dehydratase activity

D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity

Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]. [PMID:8910376, RHEA:41844]


Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(2)O. [EC:4.2.1.83, RHEA:17401]


Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H(2)O. [EC:4.2.1.62, RHEA:22064]


5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)

Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO(2) + H(2)O. [EC:4.2.1.41, RHEA:24608]


Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O. [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849]


Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O. [EC:4.2.1.5, RHEA:21836]


ATP-dependent H(4)NAD(P)OH dehydratase activity

ATP-dependent H4NAD(P)OH dehydratase activity

ATP-dependent NAD(P)H-hydrate dehydratase activity

Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate. [PMID:3061454, RHEA:19017]


L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)

Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2. [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN]


cytidine diphosphoglucose oxidoreductase activity

Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O. [EC:4.2.1.45, RHEA:17153]


citrate hydro-lyase (cis-aconitate-forming) activity

Catalysis of the reaction: citrate = cis-aconitate + H2O. [EC:4.2.1.3]


beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity

enoyl acyl carrier protein hydrase activity

crotonoyl-[acyl-carrier protein] hydratase activity

3-hydroxybutyryl acyl carrier protein dehydratase activity

(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)

beta-hydroxybutyryl acyl carrier protein dehydrase activity

crotonyl acyl carrier protein hydratase activity

Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]. [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN]


Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O. [EC:4.2.1.103, RHEA:18197]


Catalysis of the reaction: D-tartrate = H(2)O + oxaloacetate. [EC:4.2.1.81, RHEA:18289]


Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H(2)O. [EC:4.2.1.67, RHEA:12949]


D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)

Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H(2)O. [EC:4.2.1.48, RHEA:22360]


Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O. [EC:4.2.1.85, RHEA:20253]


Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. [EC:4.2.1.39, RHEA:21612]


Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H(2)O. [RHEA:23156]


isohexenylglutaconyl coenzyme A hydratase activity

Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O. [EC:4.2.1.57, RHEA:24144]


Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O. [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN]


Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone. [EC:4.2.1.95, RHEA:23604]


Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O. [EC:4.2.1.25, RHEA:20968]


Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O. [EC:4.2.1.68, RHEA:22772]


Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O. [EC:4.2.1.90, RHEA:23080]


Catalysis of the reaction: (R)-malate = H(2)O + maleate. [EC:4.2.1.31, RHEA:23692]


acetylenecarboxylate hydratase activity, producing malonate-semialdehyde

acetylmonocarboxylic acid hydrase activity

acetylenecarboxylate hydratase activity, producing 3-oxopropanoate

Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O. [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN]


Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O. [EC:4.2.1.44, RHEA:14065]


octopamine hydrolyase activity
octopamine hydro-lyase (deaminating)

Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+). [EC:4.2.1.87, RHEA:18173]


Catalysis of the reaction: (R)-10-hydroxystearate = H(2)O + oleate. [EC:4.2.1.53, RHEA:21852]


Catalysis of the reaction: phaseollidin hydrate = H(2)O + phaseollidin. [EC:4.2.1.97, RHEA:19769]


adenosylcobalamin-dependent diol dehydratase activity

coenzyme B12-dependent diol dehydrase activity

Catalysis of the reaction: propane-1,2-diol = H(2)O + propanal. [EC:4.2.1.28, RHEA:14569]


protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)

protoaphin-aglucone dehydratase (cyclizing) activity

Catalysis of the reaction: protoaphin aglucone = H(2)O + xanthoaphin. [EC:4.2.1.73, RHEA:23876]


beta-pyrazolylalaninase activity
L-serine hydro-lyase (adding pyrazole)

Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O. [EC:4.2.1.50, RHEA:24512]


Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium. [EC:4.2.1.88, RHEA:32203]


Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA. [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN]


trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)

Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+). [EC:4.2.1.77, RHEA:10320]


Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose. [EC:4.2.1.76, RHEA:21500]


Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O. [EC:4.2.1.82, RHEA:19157]


(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)

(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)

epoxypropane:coenzyme M transferase activity

epoxyalkane:coenzyme M transferase activity

Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane. [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN]


Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate. [EC:4.2.99.12, RHEA:12336]


S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)

S-alkylcysteine sulfoxide lyase activity

Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate. [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN]


L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)

L-cysteine hydrogen-sulfide-lyase (adding sulfite)

Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide. [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN]


L-cysteine-S-conjugate thiol-lyase (deaminating) activity

L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)

glutamine transaminase K/cysteine conjugate beta-lyase activity

Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN]


Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+). [EC:4.4.1.3, RHEA:19965]


L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)

Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN]


L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)

L-cysteine hydrogen-sulfide-lyase (adding HCN)

Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine. [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN]


S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity

S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)

S-alkyl-L-cysteine sulfoxide lyase activity

Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate. [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN]


Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite. [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN]


CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)

Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+). [EC:4.6.1.6, RHEA:14737]


variant-surface-glycoprotein phospholipase C activity

(glycosyl)phosphatidylinositol-specific phospholipase C activity

glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity

glycosylphosphatidylinositol-specific phospholipase C activity

Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate. [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN]


acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)

Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin. [EC:1.21.4.2, RHEA:12232]


4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity

p-hydroxyphenylacetate hydroxylase (FAD) activity

p-hydroxyphenylacetate 3-hydroxylase (FAD) activity

Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O. [RHEA:30595]


L-lysine 6-monooxygenase (NADPH) activity

Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+). [EC:1.14.13.59, RHEA:23228]


Catalysis of the hydroxylation of an ecdysteroid at carbon position 2. [PMID:12177427]


Catalysis of the hydroxylation of an ecdysteroid at carbon position 22. [PMID:12177427]


Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O. [GOC:tb]


Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. [GOC:ai, PMID:11726664]


D-lactate dehydrogenase (cytochrome c-553) activity

Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate. [RHEA:16465]


mannitol dehydrogenase (cytochrome) activity

Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+. [RHEA:17597]


vitamin K 2,3-epoxide reductase activity

vitamin-K-epoxide reductase (warfarin-insensitive) activity

Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. [RHEA:21560]


phylloquinone epoxide reductase activity

vitamin-K-epoxide reductase (warfarin-sensitive) activity

Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues. [RHEA:57744]


bicyclic monoterpenol dehydrogenase activity

Catalysis of the reaction: (+)-borneol + NAD(+) = (1R, 4R)-camphor + H(+) + NADH. [EC:1.1.1.198, RHEA:17329]


Catalysis of the reaction: (+)-neomenthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH. [EC:1.1.1.208, RHEA:23812]


Catalysis of the reaction: (+)-cis-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH. [EC:1.1.1.228, RHEA:18329]


Catalysis of the reaction: (-)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH. [EC:1.1.1.227, RHEA:22128]


Catalysis of the reaction: (-)-menthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH. [EC:1.1.1.207, RHEA:13917]


Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+. [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN]


(R)-3-hydroxyacid ester dehydrogenase activity

Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH. [EC:1.1.1.279, RHEA:24352]


(R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity

Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate. [RHEA:52692]


(S)-3-hydroxyacid ester dehydrogenase activity

Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH. [EC:1.1.1.280, RHEA:18269]


Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH. [EC:1.1.1.254, RHEA:11556]


Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH. [EC:1.1.1.199, RHEA:21876]


L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)

Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD(+) = acetoin + H(+) + NADH. [EC:1.1.1.76, RHEA:12184]


Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+. [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN]


Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH. [EC:1.1.1.263, RHEA:20665]


Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate. [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN]


type II 15-hydroxyprostaglandin dehydrogenase activity

15-hydroxyprostaglandin dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH. [EC:1.1.1.197, RHEA:11636]


dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)

NADP-linked prostaglandin D2 dehydrogenase activity

prostaglandin-D 15-dehydrogenase (NADP(+)) activity

prostaglandin-D 15-dehydrogenase (NADP+) activity

15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN]


NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity

NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity

15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP(+) + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H(+) + NADPH. [EC:1.1.1.231, RHEA:21420]


Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+. [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN]


Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH. [EC:1.1.1.268, RHEA:13249]


Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH. [EC:1.1.1.269, RHEA:21052]


Catalysis of the reaction: 2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH. [EC:1.1.1.165, RHEA:19101]


2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity

2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity

Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate. [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN]


Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH. [EC:1.1.1.126, RHEA:15109]


2-dehydropantoyl-lactone reductase (A-specific) activity

2-dehydropantolactone reductase (A-specific) activity

Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN]


Catalysis of the reaction: 2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH. [EC:1.1.1.172, RHEA:14793]


Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione. [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN]


Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH. [EC:1.1.1.52, RHEA:19585]


Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH. [EC:1.1.1.230, RHEA:20816]


3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity

Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate. [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN]


Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+. [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN]


Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH. [EC:1.1.1.102, RHEA:22640]


2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity

2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity

Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN]


m-hydroxybenzyl alcohol (NADP) dehydrogenase activity

m-hydroxybenzyl alcohol dehydrogenase activity

Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH. [EC:1.1.1.97, RHEA:22340]


Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose. [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN]


3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity

3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity

3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity

Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]. [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN]


Catalysis of the reaction: 4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde. [EC:1.1.1.61, RHEA:23948]


Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD(+) = 4-oxocyclohexanecarboxylate + H(+) + NADH. [EC:1.1.1.226, RHEA:17429]


L-threonine 4-phosphate dehydrogenase activity

NAD+-dependent threonine 4-phosphate dehydrogenase activity

NAD(+)-dependent threonine 4-phosphate dehydrogenase activity

Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+. [EC:1.1.1.262, RHEA:32275]


6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity

Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin. [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN]


Catalysis of the reaction: coformycin + NADP(+) = 8-oxocoformycin + 2 H(+) + NADPH. [EC:1.1.1.235, RHEA:23168]


alcohol:NAD(P)+ oxidoreductase activity
aldehyde reductase (NADPH/NADH)

alcohol dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+. [EC:1.1.1.71]


dehydrogenase, D-aldohexose
aldose dehydrogenase activity
D-aldose:NAD+ 1-oxidoreductase activity

Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH. [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN]


NADP-dependent aldose 6-phosphate reductase activity

NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity

alditol 6-phosphate:NADP 1-oxidoreductase activity

aldose-6-phosphate reductase (NADPH) activity

Catalysis of the reaction: D-glucitol 6-phosphate + NADP(+) = D-glucose 6-phosphate + H(+) + NADPH. [EC:1.1.1.200, RHEA:20037]


Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH. [EC:1.1.1.54, RHEA:12168]


Catalysis of the reaction: D-apiitol + NAD(+) = D-apiose + H(+) + NADH. [EC:1.1.1.114, RHEA:15301]


aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)

NADPH-linked benzaldehyde reductase activity

aryl-alcohol dehydrogenase (NADP+) activity

Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH. [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN]


benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity

Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH. [EC:1.1.1.217, RHEA:16405]


Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH. [EC:1.1.1.108, RHEA:19265]


Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH. [EC:1.1.1.225, RHEA:14401]


Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one. [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN]


Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH. [RHEA:34631]


Catalysis of the reaction: codeine + NADP(+) = codeinone + H(+) + NADPH. [EC:1.1.1.247, RHEA:19209]


Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH. [EC:1.1.1.194, MetaCyc:RXN-1107]


Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH. [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN]


D-arabinitol 2-dehydrogenase (ribulose-forming) activity

Catalysis of the reaction: D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH. [EC:1.1.1.250, RHEA:17389]


Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH. [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN]


Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH. [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN]


Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH. [EC:1.1.1.142, RHEA:20437]


L-fucose (D-arabinose) dehydrogenase activity

Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH. [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN]


D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity

D-xylose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH. [EC:1.1.1.179, RHEA:22000]


diethyl 2-methyl-3-oxosuccinate reductase activity

Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH. [EC:1.1.1.229, RHEA:21008]


Catalysis of the reaction: dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH. [EC:1.1.1.160, RHEA:15925]


Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH. [EC:1.1.1.96, RHEA:20293]


Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO(2) + NADH. [EC:1.1.1.84, RHEA:13321]


Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH. [EC:1.1.1.266, RHEA:36583]


thymidine diphospho-6-deoxy-L-talose dehydrogenase activity

Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH. [EC:1.1.1.134, RHEA:23648]


Catalysis of the reaction: D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH. [EC:1.1.1.162, RHEA:18005]


farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity

Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH. [EC:1.1.1.216, RHEA:14697]


Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH. [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN]


5-ketofructose reductase (NADP+) activity

5-ketofructose reductase (NADP(+)) activity

fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity

Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH. [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN]

fructose 5-dehydrogenase (NADP+) activity


Catalysis of the reaction: galactitol + NAD(+) = D-tagatose + H(+) + NADH. [EC:1.1.1.16, RHEA:20685]


galactose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH. [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN]


guanosine diphospho-6-deoxy-D-talose dehydrogenase activity

Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+. [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN]


Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]


guanosine diphosphomannose dehydrogenase activity

guanosine diphospho-D-mannose dehydrogenase activity

Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH. [EC:1.1.1.132, RHEA:21728]


Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH. [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN]


Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH. [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN]


NADP-linked aldohexose dehydrogenase activity

NADP-dependent glucose dehydrogenase activity

nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity

glucose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH. [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN]


Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH. [EC:1.1.1.20, RHEA:18925]


dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity

glycerol 2-dehydrogenase (NADP+) activity

Catalysis of the reaction: glycerol + NADP(+) = glycerone + H(+) + NADPH. [EC:1.1.1.156, RHEA:12753]


glycerol dehydrogenase (NADP+) activity
glycerol:NADP+ oxidoreductase activity

Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH. [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN]


glycerol-1-phosphate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate. [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN]


glycerol-3-phosphate dehydrogenase (NAD(P)+) activity

glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity

glycerol-3-phosphate dehydrogenase [NADP+] activity

glycerol-3-phosphate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+. [EC:1.1.1.94]


NADH-dependent glyoxylate reductase activity


Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH. [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN]


Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH. [EC:1.1.1.166, RHEA:10516]


Catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate. [EC:1.1.1.167, RHEA:11284]


Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH. [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN, RHEA:10780]


Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN]


indole-3-acetaldehyde reductase (NADH) activity

Catalysis of the reaction: indole-3-ethanol + NAD(+) = (indol-3-yl)acetaldehyde + H(+) + NADH. [EC:1.1.1.190, RHEA:14873]


indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity

indole-3-acetaldehyde reductase (NADPH) activity

Catalysis of the reaction: indole-3-ethanol + NADP(+) = (indol-3-yl)acetaldehyde + H(+) + NADPH. [EC:1.1.1.191, RHEA:17037]


indolelactate dehydrogenase (NADH) activity

Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD(+) = 3-(indol-3-yl)pyruvate + H(+) + NADH. [RHEA:20133]


inositol:NAD 2-dehydrogenase activity
myo-inositol 2-dehydrogenase activity

Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH. [EC:1.1.1.18, RHEA:16949]


isopropanol dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH. [EC:1.1.1.80, RHEA:21792]


L-arabinitol 2-dehydrogenase (ribulose forming) activity

Catalysis of the reaction: L-arabinitol + NAD(+) = L-ribulose + H(+) + NADH. [EC:1.1.1.13, RHEA:21356]


Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH. [EC:1.1.1.12, RHEA:16381]


L-arabinose 1-dehydrogenase (NAD+) activity

Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH. [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN]


TPN-L-gulonate dehydrogenase activity
glucuronate dehydrogenase activity
NADP-L-gulonate dehydrogenase activity
glucuronate reductase activity
D-glucuronate dehydrogenase activity

Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH. [EC:1.1.1.19, RHEA:14909]


glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity

Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+. [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN]


Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH. [EC:1.1.1.45, RHEA:12889]


Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+. [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN]


Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH. [EC:1.1.1.173, RHEA:12649]


Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH. [EC:1.1.1.129, RHEA:23376]


Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH. [EC:1.1.1.113, RHEA:15789]


Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH. [EC:1.1.1.10, RHEA:17025]


lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity

Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH. [EC:1.1.1.55, RHEA:15885]


long-chain alcohol dehydrogenase activity

Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH. [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN]


NADP-dependent mannitol dehydrogenase activity

mannitol 2-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH. [EC:1.1.1.138, RHEA:16765]


Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH. [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN]


NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity

NADPH-dependent mannose 6-phosphate reductase activity

Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH. [EC:1.1.1.224, RHEA:14925]


D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))

mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity

Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+. [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN]


Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH. [EC:1.1.1.244, RHEA:19401]


Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+. [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN]


Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH. [EC:1.1.1.240, RHEA:23144]


Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH. [EC:1.1.1.233, RHEA:11540]


Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH. [EC:1.1.1.66, RHEA:20880]


oxaloglycolate reductase (decarboxylating) activity

Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate. [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN]


Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH. [EC:1.1.1.106, RHEA:23000]


Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH. [EC:1.1.1.7, RHEA:21584]


9-keto-prostaglandin E(2) reductase activity

prostaglandin E 9-ketoreductase activity

9-keto-prostaglandin E2 reductase activity

Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]


prostaglandin 11-keto reductase activity

NADPH-dependent prostaglandin D2 11-keto reductase activity

prostaglandin D2 11-ketoreductase activity

Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN]


Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH. [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN]


Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH. [EC:1.1.1.107, RHEA:21336]


adonitol dehydrogenase activity
ribitol:NAD+ 2-oxidoreductase activity

Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH. [EC:1.1.1.56, RHEA:20053]


Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+. [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN]


Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH. [EC:1.1.1.115, RHEA:11676]


Catalysis of the reaction: (7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine. [EC:1.1.1.248, RHEA:10108]


Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH. [EC:1.1.1.143, RHEA:11300]


reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity

sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity

sorbose 5-dehydrogenase (NADP+) activity

Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH. [EC:1.1.1.123, RHEA:15001]


12alpha-hydroxy steroid dehydrogenase activity


16alpha-hydroxy steroid dehydrogenase activity

Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid. [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN]


21-hydroxysteroid dehydrogenase (NAD+) activity


21-hydroxysteroid dehydrogenase (NADP+) activity


3(or 17)alpha-hydroxysteroid dehydrogenase activity

3(or 17)-alpha-hydroxysteroid dehydrogenase activity


3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity


3alpha(or 20beta)-hydroxysteroid dehydrogenase activity

3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity


3-alpha-hydroxysteroid dehydrogenase (A-specific) activity


3beta(or 20alpha)-hydroxysteroid dehydrogenase activity

3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity


NADP-dependent 7beta-hydroxysteroid dehydrogenase activity

NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity

7-beta-hydroxysteroid dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid. [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN]


17alpha-hydroxy steroid oxidoreductase activity

17alpha-hydroxy steroid dehydrogenase activity

Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+. [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN]


Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN]

testosterone 17-beta-dehydrogenase (NADP+) activity


3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity

sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity

Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one. [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN]


Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone. [EC:1.1.1.260, RHEA:24484]


Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol. [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN]


Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone. [EC:1.1.1.206, RHEA:18357]


tropinone (psi-tropine-forming) reductase activity

pseudotropine forming tropinone reductase activity

Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone. [EC:1.1.1.236, RHEA:24244]


uridine diphosphoacetylglucosamine dehydrogenase activity

Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate. [EC:1.1.1.136, RHEA:13325]


uronate: NAD-oxidoreductase activity
uronic acid dehydrogenase activity
uronate:NAD+ 1-oxidoreductase activity

Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH. [EC:1.1.1.203, RHEA:22404]


Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine. [EC:1.1.1.273, RHEA:20029]


Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH. [EC:1.1.1.221, RHEA:22804]


(R)-pantoyllactone dehydrogenase (flavin) activity

2-dehydropantoyl-lactone reductase (flavin) activity

2-dehydropantolactone reductase (flavin) activity

(R)-pantolactone dehydrogenase (flavin) activity

Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2). [EC:1.1.99.27, RHEA:21004]


Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]


Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione. [EC:1.1.99.26, RHEA:15905]


alkan-1-ol dehydrogenase (acceptor) activity

Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor. [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN]


phanerochaete chrysosporium cellobiose oxidoreductase activity

cellobiose dehydrogenase (acceptor) activity

Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor. [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN]


Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate. [EC:1.1.99.6, RHEA:15089]


D-sorbitol dehydrogenase (acceptor) activity

Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor. [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN]


Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2). [EC:1.1.99.4, RHEA:12368]


Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2). [EC:1.1.99.11, RHEA:22304]


Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone. [EC:1.1.99.28, RHEA:20637]


glycerol dehydrogenase (acceptor) activity

Catalysis of the reaction: A + glycerol = AH(2) + glycerone. [EC:1.1.99.22, RHEA:17493]


Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN]


Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate. [EC:1.1.99.7, RHEA:10984]


Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor. [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN]


Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2). [EC:1.1.99.12, RHEA:14713]


Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor. [RHEA:22752]


Catalysis of the reaction: (S)-4-hydroxymandelate + H(+) + O(2) = 4-hydroxybenzaldehyde + CO(2) + H(2)O(2). [EC:1.1.3.19, RHEA:15833]


AOX activity
alcohol:oxygen oxidoreductase activity
ethanol oxidase activity

Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2. [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN]


Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2. [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN]


Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O. [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN]


Catalysis of the reaction: mannitol + O2 = mannose + H2O2. [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN]


Catalysis of the reaction: Ecdysone + O(2) = 3-dehydroecdysone + H(2)O(2). [EC:1.1.3.16, RHEA:11796]


Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202. [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN]


Catalysis of the reaction: (2S)-2-hydroxyphytanate + O(2) = 2-oxophytanate + H(2)O(2). [EC:1.1.3.27, RHEA:21680]


Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+). [EC:1.3.3.12, RHEA:20617]


Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2. [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN, RHEA:32363]


Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2). [EC:1.1.3.11, RHEA:17853]


Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+). [EC:1.1.3.29, RHEA:13029]


Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2. [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN]


Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2). [EC:1.1.3.10, RHEA:10552]


Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2. [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN]


Catalysis of the reaction: xylitol + O2 = xylose + H2O2. [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN]


cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity

cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity

Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose. [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN]


Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown. [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN]


ascorbate-cytochrome b5 reductase activity

transmembrane ascorbate ferrireductase activity

Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction. [PMID:16911521, PMID:24449903, RHEA:30403]


Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH. [EC:1.10.1.1, RHEA:22184]


3-hydroxyanthranilic acid oxidase activity

Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2). [EC:1.10.3.5, RHEA:17245]


Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O. [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN]


Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O. [EC:1.10.3.6, RHEA:11292]


benzyl viologen-nitrate reductase activity

Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite. [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN]


Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+. [EC:1.9.98.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN]


H(2):ferricytochrome c3 oxidoreductase activity

H2:ferricytochrome c3 oxidoreductase activity

Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3. [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN]


Catalysis of the reaction: NADP+ + H2 = NADPH + H+. [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN]


H(2):NAD(+) oxidoreductase activity
NAD-linked hydrogenase activity
H2:NAD+ oxidoreductase activity
hydrogen:NAD+ oxidoreductase activity

Catalysis of the reaction: H2 + NAD+ = H+ + NADH. [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN]


oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound. [GOC:jl]


Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone. [EC:1.12.5.1, RHEA:18641]


oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound. [GOC:ai]


hydrogen:coenzyme F420 oxidoreductase activity

coenzyme F420-dependent hydrogenase activity

Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420. [EC:1.12.98.1, RHEA:23760]


H(2)-dependent methylene-H(4)MPT dehydrogenase activity

H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity

H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity

H2-dependent methylene-H4MPT dehydrogenase activity

Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+). [EC:1.12.98.2, RHEA:20017]


cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)

reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)

Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2. [EC:1.6.2.5]


reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity

Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. [EC:1.6.5.11, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN]


Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+). [EC:1.6.5.7, RHEA:12428]


oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor


cytochrome c-551:O2, NO2+ oxidoreductase activity

nitrite reductase (cytochrome; NO-forming) activity

NO-forming nitrite reductase (cytochrome) activity

Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN]


trimethylamine:cytochrome c oxidoreductase activity

trimethylamine-N-oxide reductase (cytochrome c) activity

Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+. [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN]


assimilatory ferredoxin-nitrate reductase activity

Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin. [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN]


hydroxylamine (acceptor) reductase activity

Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor. [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN]


Catalysis of the reaction: H(2)O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide. [EC:1.7.2.4, MetaCyc:RXN-12130]


Catalysis of the reaction: 3-aci-nitropropanoate + H(2)O + O(2) = 3-oxopropanoate + H(2)O(2) + nitrite. [EC:1.7.3.5, RHEA:22372]


Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown. [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN]


HAO
hydroxylamine oxidoreductase
hydroxylamine oxidase activity

Catalysis of the reaction: hydroxylamine + O(2) = H(2)O + H(+) + nitrite. [RHEA:19969]


Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2. [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN]


oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]


NADPH-dependent DMAB N-oxide reductase activity

N,N-dimethyl-p-aminoazobenzene oxide reductase activity

dimethylaminoazobenzene N-oxide reductase activity

Catalysis of the reaction: 4-(dimethylamino)azobenzene + H(2)O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH. [EC:1.7.1.11, RHEA:19789]


N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity

nicotinamide adenine dinucleotide (phosphate) azoreductase activity

Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+. [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN]


Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+. [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN]


Catalysis of the reaction: 2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH. [EC:1.7.1.5, RHEA:19337]


Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+. [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN]


NAD(P)H bispecific nitrate reductase activity

assimilatory NADPH-nitrate reductase activity

triphosphopyridine nucleotide-nitrate reductase activity

nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity

assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity

Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+. [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]


nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity

Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+. [EC:1.7.1.4, PMID:31961593]


4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity

4-nitroquinoline 1-oxide reductase activity

Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+. [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN]


1,1,2-trichloroethylene reductive dehalogenase activity

1,1,2-trichloroethene reductive dehalogenase activity

Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene. [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271]


Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H(2)O + H(+). [EC:1.97.1.1, RHEA:16349]


2,4,6-TCP reductive dehalogenase activity

2,4,6-trichlorophenol reductive dehalogenase activity

ortho-trichlorophenol reductive dehalogenase activity

Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl. [GOC:ai, PMID:12697029]


tetrachloroethene reductive dehalogenase activity

Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. [EC:1.21.99.5, MetaCyc:1.97.1.8-RXN]


2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity

Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2. [UM-BBD_reactionID:r0274]


Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate. [EC:1.14.20.13, RHEA:12797]


desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity

Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2. [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN]


oxygenase, gibberellin A44 oxidase activity

(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity

Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2. [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN]


Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O(2) = (6S)-6-hydroxyhyoscyamine + CO(2) + succinate. [EC:1.14.11.11, RHEA:12629]


Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2. [GOC:clt, PMID:10482536]


alpha-ketoglutarate-dependent taurine dioxygenase activity

taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)

Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite. [EC:1.14.11.17, RHEA:15909]


Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2. [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN]


epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity

trimethyllysine alpha-ketoglutarate dioxygenase activity

Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate. [EC:1.14.11.8, RHEA:14181]


Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O(2) = 2,5-dihydroxypyridine + A + H(2)O. [EC:1.14.99.26, RHEA:16973]


Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O. [EC:1.14.99.23, RHEA:14193]


androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)

Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O(2) = A + H(2)O + testololactone. [EC:1.14.99.12, RHEA:22696]


Catalysis of the reaction: AH(2) + estradiol-17beta + O(2) = 6beta-hydroxyestradiol-17beta + A + H(2)O. [EC:1.14.99.11, RHEA:19137]


Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+. [PMID:4041238, RHEA:18745]


Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor. [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN]


Latia luciferin monooxygenase (demethylating)

Latia-luciferin monooxygenase (demethylating) activity

Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin. [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN]


Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O. [EC:1.14.14.84, RHEA:32635]


myristoyl-CoA 11-(E) desaturase activity

Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. [RHEA:46396]


myristoyl-CoA 11-(Z) desaturase activity

Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. [RHEA:25852]


16:0 monogalactosyldiacylglycerol desaturase activity

Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule. [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307]


phylloquinone monooxygenase (2,3-epoxidizing) activity

Catalysis of the reaction: AH(2) + O(2) + phylloquinone = 2,3-epoxyphylloquinone + A + H(2)O. [EC:1.14.99.20, RHEA:16745]


1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity

Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O. [RHEA:22956]


Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O. [EC:1.14.99.14, RHEA:18205]


Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate. [EC:1.14.99.4, RHEA:11984]


Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O. [EC:1.14.99.24, RHEA:19557]


Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol. [RHEA:14049]


thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity

Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+). [EC:1.14.99.35, RHEA:18929]


Catalysis of the reaction: (-)-menthol + H(+) + NADPH + O(2) = 1,4-menthane-3,8-diol + H(2)O + NADP(+). [EC:1.14.13.46, RHEA:11648]


Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+). [RHEA:11996]


Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O(2) = 6-oxohexanoate + H(2)O + NADP(+). [EC:1.14.13.66, RHEA:33283]


2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)

Catalysis of the reaction: 2-nitrophenol + 2 H(+) + 2 NADPH + O(2) = catechol + H(2)O + 2 NADP(+) + nitrite. [EC:1.14.13.31, RHEA:19457]


Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol. [RHEA:24308]


Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H(+) + NADPH + O(2) = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(2)O + NADP(+). (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol. [EC:1.14.14.93, RHEA:15321]


Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate. [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN]


cytochrome P450II-dependent monooxygenase activity

cytochrome P450-II-dependent monooxygenase activity

(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity

4-hydroxybenzeneacetaldehyde oxime monooxygenase activity

NADPH-cytochrome P450 reductase (CYP71E1)

4-hydroxyphenylacetaldehyde oxime monooxygenase activity

Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+). [EC:1.14.14.37, RHEA:18401]


Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-4-ol = H(2)O + NAD(+) + quinoline-3,4-diol. [EC:1.14.13.62, RHEA:19325]


Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate. [EC:1.14.14.96, MetaCyc:1.14.13.36-RXN]


Catalysis of the reaction: 6-oxocineole + H(+) + NADPH + O(2) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H(2)O + NADP(+). [EC:1.14.13.51, RHEA:24324]


Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O. [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN]


Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+). [EC:1.14.13.32, RHEA:10796]


Catalysis of the reaction: anhydrotetracycline + H(+) + NADPH + O(2) = 12-dehydrotetracycline + H(2)O + NADP(+). [EC:1.14.13.38, RHEA:11976]


Catalysis of the reaction: benzoyl-CoA + H(+) + NADPH + O(2) = 3-hydroxybenzoyl-CoA + H(2)O + NADP(+). [EC:1.14.13.58, RHEA:23216]


Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O. [EC:1.14.15.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN]


cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)

Catalysis of the reaction: cyclopentanone + H(+) + NADPH + O(2) = 5-valerolactone + H(2)O + NADP(+). [EC:1.14.13.16, RHEA:15737]


Catalysis of the reaction: dihydrochelirubine + H(+) + NADPH + O(2) = 12-hydroxydihydrochelirubine + H(2)O + NADP(+). [EC:1.14.14.101, RHEA:10156]


Catalysis of the reaction: dihydrosanguinarine + H(+) + NADPH + O(2) = 10-hydroxydihydrosanguinarine + H(2)O + NADP(+). [EC:1.14.14.100, RHEA:10528]


Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H(+) + NADPH + O(2) = 4-hydroxymandelonitrile + H(2)O + NADP(+). [RHEA:50732]


Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+). [EC:1.14.13.5, RHEA:19425]


Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [RHEA:18849]


Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O. [EC:1.14.14.88, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN]


progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)

androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)

17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)

ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)

Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]


Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [PMID:11461919, PMID:15364545, PMID:8486631, PMID:9675028, RHEA:22176]


Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+). [EC:1.14.13.34, RHEA:24120]


Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+). [EC:1.14.13.4, RHEA:17669]


Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine. [EC:1.14.14.97, MetaCyc:1.14.13.37-RXN]


Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+). [EC:1.14.14.102, RHEA:16649]


Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+). [RHEA:46360]


Catalysis of the reaction: H(+) + NADPH + O(2) + protopine = 6-hydroxyprotopine + H(2)O + NADP(+). [EC:1.14.14.98, RHEA:22644]


questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)

Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+). [EC:1.14.13.43, RHEA:10836]


Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). [EC:1.14.14.55, RHEA:20149]


sterol 14-alpha-demethylase activity
sterol 14-demethylase activity
lanosterol 14alpha-demethylase activity
sterol 14alpha-demethylase activity

Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. [RHEA:54028]


Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+). [EC:1.14.14.103, RHEA:14133]


taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)

Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+). [EC:1.14.14.105, RHEA:15241]


Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol. [EC:1.14.14.106, RHEA:18949]


Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O. [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN]


trans-cinnamic acid 2-hydroxylase activity

Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+). [EC:1.14.13.14, RHEA:10956]


Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O. [MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN]


Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine. [EC:1.14.14.104, RHEA:17257]


2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity

methylhydroxypyridine carboxylate dioxygenase activity

Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate. [EC:1.14.13.242, MetaCyc:1.14.12.4-RXN]


Catalysis of the reaction: 5-pyridoxate + NADPH + O(2) = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP(+). [RHEA:11152]


alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)

alkanal monooxygenase (FMN-linked) activity

Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light. [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN]


Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN]


Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN]


Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate. [EC:1.14.16.6, RHEA:21716]


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated. [GOC:mah]


(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity

Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:21456]


(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity

Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:20485]


(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity

Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:13773]


Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 <=> berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:23576]


(R)-reticuline oxidase (C-C phenol-coupling) activity

Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:17713]


triphosphopyridine nucleotide peroxidase activity

nicotinamide adenine dinucleotide phosphate peroxidase activity

Catalysis of the reaction: H(2)O(2) + H(+) + NADPH = 2 H(2)O + NADP(+). [EC:1.11.1.2, RHEA:15173]


peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)

phospholipid-hydroperoxide glutathione peroxidase activity

Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione. [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN]

phospholipid hydroperoxide glutathione peroxidase activity


Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid. [EC:1.20.4.2, RHEA:15969]


oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H. [GOC:mah]


NAD-dependent phosphite dehydrogenas activity

Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate. [EC:1.20.1.1, RHEA:13173]


oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors

OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP. [GOC:ai]


Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+). [EC:1.20.99.1, RHEA:18449]


oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors

Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP. [GOC:ai]


reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)

Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate. [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN]


Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal. [EC:1.13.11.67, RHEA:26023]


arginine oxygenase (decarboxylating) activity

Catalysis of the reaction: L-arginine + O(2) = 4-guanidinobutanamide + CO(2) + H(2)O. [EC:1.13.12.1, RHEA:10548]


Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light. [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]


lactate oxidative decarboxylase activity

Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O. [EC:1.13.12.4, RHEA:16513]


Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O. [EC:1.13.12.2, RHEA:14601]


phenylalanine (deaminating, decarboxylating)oxidase activity

phenylalanine (deaminating, decarboxylating) oxidase activity

L-phenylalanine oxidase (deaminating and decarboxylating)

l-phenylalanine oxidase (deaminating and decarboxylating) activity

Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O. [EC:1.13.12.9, RHEA:10712]


Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity

Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)

Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin. [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]

Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)


Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light. [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN]


Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide. [EC:1.13.12.3, RHEA:16165]


Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light. [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN]


Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-carboxy-cis,cis-muconate + 2 H(+). [EC:1.13.11.28, RHEA:15369]


2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity

Catalysis of the reaction: 2,3-dihydroxyindole + O(2) = anthranilate + CO(2) + H(+). [EC:1.13.11.23, RHEA:19445]


Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O(2) = 4-hydroxybenzoate + formate + 2 H(+). [EC:1.13.11.41, RHEA:24416]


Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate. [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN]


Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+). [EC:1.13.11.25, RHEA:21352]


Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN]


1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity

Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO. [EC:1.13.11.48, RHEA:21572]


Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate. [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN]


Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate. [RHEA:35595]


Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2. [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN]


Catalysis of the reaction: 7,8-dihydroxykynurenate + O(2) = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+). [EC:1.13.11.10, RHEA:23400]


arachidonate omega6 lipoxygenase activity

linoleic acid omega6-lipoxygenase activity

arachidonate omega(6) lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. [EC:1.13.11.33]


Catalysis of the reaction: arachidonate + O(2) = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. [EC:1.13.11.40, RHEA:14985]


Catalysis of the reaction: trans-caffeate + O(2) = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+). [EC:1.13.11.22, RHEA:22216]


Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O(2) = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+). [EC:1.13.11.36, RHEA:20449]


Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine. [EC:1.13.11.19, RHEA:14409]


Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid. [UM-BBD_reactionID:r0422]


Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid. [UM-BBD_reactionID:r0415]


Catalysis of the reaction: 2,5-dihydroxybenzoate + O(2) = 3-maleylpyruvate + H(+). [EC:1.13.11.4, RHEA:18237]


Catalysis of the reaction: indole + O(2) = 2-formamidobenzaldehyde. [EC:1.13.11.17, RHEA:11212]


lignostilbene alpha beta-dioxygenase activity

Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin. [EC:1.13.11.43, RHEA:21340]


Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate. [EC:1.13.11.45, RHEA:18993]


Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine. [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN, PMID:4403729]


Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+). [EC:1.13.11.35, RHEA:19673]


Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN]


Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN]


Catalysis of the reaction: sulfur + O2 + H2O = sulfite. [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN]


Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+). [RHEA:23696]


tryptophan side-chain alpha,beta-oxidase activity

Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3. [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN]


sulfite-cytochrome c oxidoreductase activity

Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c. [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN]


Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c. [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN]


glutathione-dependent thiol:disulfide oxidoreductase activity

enzyme-thiol transhydrogenase (oxidized-glutathione) activity

enzyme-thiol transhydrogenase (glutathione-disulphide) activity

enzyme-thiol transhydrogenase (glutathione-disulfide) activity

Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase. [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN]


glutathione:coenzyme A-glutathione transhydrogenase activity

glutathione coenzyme A-glutathione transhydrogenase activity

coenzyme A:glutathione-disulfide oxidoreductase activity

glutathione-coenzyme A glutathione disulfide transhydrogenase activity

coenzyme A:oxidized-glutathione oxidoreductase activity

Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione. [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN]


Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine. [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN]


Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine. [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN]


sulphite reductase (ferredoxin) activity

Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin. [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN]


NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity

2-oxopropyl-CoM reductase (carboxylating) activity

Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH. [EC:1.8.1.5, RHEA:16977]


Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH. [RHEA:14881]


Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+. [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN]


coenzyme A glutathione disulfide reductase activity

NADPH-dependent coenzyme A-SS-glutathione reductase activity

CoA-glutathione reductase (NADPH) activity

coenzyme A disulfide-glutathione reductase activity

Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+. [RHEA:14617]


NADH-dependent cystine reductase activity

Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH. [EC:1.8.1.6, RHEA:20597]


Catalysis of the reaction: H(2)O + hypotaurine + NAD(+) = H(+) + NADH + taurine. [RHEA:17385]


Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione. [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN]


AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)

adenosine phosphosulfate reductase activity

AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)

Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor. [EC:1.8.99.2, PMID:5421934]


Catalysis of the reaction: 2 glutathione + O(2) = glutathione disulfide + H(2)O(2). [EC:1.8.3.3, RHEA:24112]


Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2. [GOC:hjd, RHEA:53892]


Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin. [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN]


formate:cytochrome b1 oxidoreductase activity

formate dehydrogenase (cytochrome) activity

Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1. [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN]


formate dehydrogenase (cytochrome c-553)

formate dehydrogenase (cytochrome-c-553) activity

Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. [EC:1.17.2.3, MetaCyc:1.2.2.3-RXN]


2-ketoglutarate ferredoxin oxidoreductase activity

2-oxoglutarate ferredoxin oxidoreductase activity

Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin. [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN]


D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity

Catalysis of the reaction: (R)-4-dehydropantoate + H(2)O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH. [EC:1.2.1.33, RHEA:19349]


NAD-dependent alpha-ketoaldehyde dehydrogenase activity

2-oxoaldehyde dehydrogenase (NAD+) activity

NAD-linked alpha-ketoaldehyde dehydrogenase activity

Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+. [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN]


NADP-linked alpha-ketoaldehyde dehydrogenase activity

NADP-dependent alpha-ketoaldehyde dehydrogenase activity

2-oxoaldehyde dehydrogenase (NADP+) activity

Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+. [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN]


2-oxoisovalerate dehydrogenase (acylating) activity

Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA. [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN]


Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate. [PMID:8496170, RHEA:34627]


Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate. [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN]


Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate. [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN]


2-hydroxymuconic semialdehyde dehydrogenase activity

2-aminomuconate semialdehyde dehydrogenase activity

2-hydroxymuconate semialdehyde dehydrogenase activity

alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity

2-hydroxymuconic acid semialdehyde dehydrogenase activity

alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity

Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate. [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN]


aryl-aldehyde dehydrogenase (NADP+) activity

Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP. [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN]


Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+. [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN]


coniferyl aldehyde:NAD(P)+ oxidoreductase activity

Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+. [EC:1.2.1.68, MetaCyc:RXN-1241]


NADP-dependent formate dehydrogenase activity

Catalysis of the reaction: formate + NADP(+) = CO(2) + NADPH. [EC:1.17.1.10, RHEA:12000]


Catalysis of the reaction: 4-guanidinobutanal + H(2)O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH. [EC:1.2.1.54, RHEA:14381]


glutarate semialdehyde dehydrogenase (NAD+) activity

glutarate-semialdehyde dehydrogenase (NAD+) activity

Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH. [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN]


NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity

triosephosphate dehydrogenase (NADP+) activity

triosephosphate dehydrogenase (NADP(+)) activity

dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)

NADP-dependent glyceraldehyde phosphate dehydrogenase activity

glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)

NADP-triose phosphate dehydrogenase activity

glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity

Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate. [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN]


Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH. [EC:1.2.1.21, RHEA:20001]


hexadecanal dehydrogenase (acylating) activity

Catalysis of the reaction: CoA + NAD(+) + palmitaldehyde = H(+) + NADH + palmitoyl-CoA. [EC:1.2.1.42, RHEA:19705]


long-chain fatty aldehyde dehydrogenase activity

fatty aldehyde:NAD+ oxidoreductase activity

long-chain aliphatic aldehyde dehydrogenase activity

Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons. [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN]


long-chain fatty acyl CoA reductase activity

long-chain fatty acyl-CoA reductase activity

Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH. [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]


NAD/factor-dependent formaldehyde dehydrogenase activity

mycothiol-dependent formaldehyde dehydrogenase activity

Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+. [EC:1.1.1.306, MetaCyc:1.2.1.66-RXN]


oxoglutarate dehydrogenase (NADP+) activity

Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA. [EC:1.2.1.52, RHEA:21400]


phenylglyoxylate dehydrogenase (acylating) activity

Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH. [EC:1.2.1.58, RHEA:10372]


Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH. [EC:1.2.1.51, RHEA:17425]


cytosolic retinal dehydrogenase activity

Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. [EC:1.2.1.36]


Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate. [EC:1.2.1.67, RHEA:13309]


aldehyde dehydrogenase (acceptor) activity

aldehyde dehydrogenase (quinone) activity

Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol. [EC:1.2.5.2, MetaCyc:1.2.99.3-RXN]


Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor. [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN]


Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate. [EC:1.2.98.1, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN]


Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate. [EC:1.2.3.5, RHEA:14837]


Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+). [EC:1.2.3.7, RHEA:16277]


oxalate:oxygen oxidoreductase activity
aero-oxalo dehydrogenase activity
oxalic acid oxidase activity

Catalysis of the reaction: 2 H(+) + O(2) + oxalate = 2 CO(2) + H(2)O(2). [RHEA:21880]


pyruvate oxidase (CoA-acetylating) activity

Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2). [EC:1.2.3.6, RHEA:21912]


phosphate-dependent pyruvate oxidase activity

Catalysis of the reaction: H(+) + O(2) + phosphate + pyruvate = acetyl phosphate + CO(2) + H(2)O(2). [EC:1.2.3.3, RHEA:20848]


Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN]


Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin. [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN]


Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN]


Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin. [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN]


Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN]


terephthalate 1,2-cis-dihydrodiol dehydrogenase activity

Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO(2) + NADH. [EC:1.3.1.53, RHEA:10744]


Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH. [EC:1.3.1.73, RHEA:12320]


3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity

Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol. [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN]


Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+. [EC:1.3.1.48, KEGG_REACTION:R04556, KEGG_REACTION:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]


Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+. [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN]


Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+. [EC:1.3.1.45, MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN]


Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + H(+) + NADH. [EC:1.3.1.11, RHEA:21444]


Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+. [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN]


hexadecanal: NADP+ oxidoreductase activity

Catalysis of the reaction: NADP(+) + palmitaldehyde = trans-hexadec-2-enal + H(+) + NADPH. [EC:1.3.1.27, RHEA:12444]


2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity

Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH. [EC:1.3.1.40, RHEA:24268]


Catalysis of the reaction: 2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH. [PMID:10989435, PMID:6401712, RHEA:43780]


Catalysis of the reaction: 3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH. [EC:1.3.1.17, RHEA:20257]


Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol. [ISBN:0943088399]


Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+. [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN]


Catalysis of the reaction: 3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH. [EC:1.3.1.16, RHEA:23892]


Catalysis of the reaction: dihydrobiochanin A + NADP(+) = biochanin A + H(+) + NADPH. [EC:1.3.1.46, RHEA:12817]


reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity

Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH. [EC:1.3.1.22, RHEA:24552]


NADPH-dependent cis-enoyl-CoA reductase activity

cis-2-enoyl-coenzyme A reductase activity

cis-2-enoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH. [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN]


Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+. [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN]


NAD(P)H: cucurbitacin B delta23-oxidoreductase activity

cucurbitacin delta(23) reductase activity

Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+. [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN]


Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2. [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN]


Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN]


Catalysis of the reaction: geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + H(+) + NADPH. [EC:1.3.1.36, RHEA:11376]


7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity

Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH. [EC:1.3.1.18, RHEA:22248]


Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH. [EC:1.3.1.7, RHEA:18553]


Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate. [EC:1.3.1.15, RHEA:14861]


Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH. [RHEA:12564]


Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN]


Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN]


trans-2-enoyl-CoA reductase (NAD+) activity

Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH. [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN]


Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin. [EC:1.3.1.41, RHEA:13417]


Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin. [EC:1.3.1.69, RHEA:12757]


2-furoyl coenzyme A dehydrogenase activity

2-furoyl coenzyme A hydroxylase activity

Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+). [EC:1.3.99.8, RHEA:21480]


Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor. [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN]