transferase activity, transferring other glycosyl groups

OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor). [GOC:jl]


Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. [MetaCyc:RXN0-5061]


Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+. [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127]


murein lytic endotransglycosylase E activity


Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. [GOC:cjm, PMID:26192491, Wikipedia:Sialyltransferase]


GalNAc alpha-2,6-sialyltransferase I activity

Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. [EC:2.4.99.3]


ganglioside GD3 synthetase sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. [EC:2.4.99.8]


Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. [EC:2.4.99.1]


Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor. [GOC:mengo_curators, PMID:7826016, PMID:8405811]


Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. [EC:2.4.99.6, RHEA:52316]

cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity


cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide. [EC:2.4.99.10]


transferase activity, transferring pentosyl groups

Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). [GOC:jl]


methylthioadenosine nucleoside phosphorylase activity

Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. [EC:2.4.2.28]


adenine phosphoribosylpyrophosphate transferase activity

Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.7]


phosphoribosyl pyrophosphate amidotransferase activity

glutamine 5-phosphoribosylpyrophosphate amidotransferase activity

phosphoribose pyrophosphate amidotransferase activity

phosphoribosylpyrophosphate glutamyl amidotransferase activity

glutamine phosphoribosyldiphosphate amidotransferase activity

glutamine phosphoribosylpyrophosphate amidotransferase activity

Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. [EC:2.4.2.14, RHEA:14905]

glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity


anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity

anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity

Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. [EC:2.4.2.18, RHEA:11768]


phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity

phosphoribosyladenosine triphosphate pyrophosphorylase activity

phosphoribosyladenosine triphosphate synthetase activity

phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity

Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.17]

adenosine triphosphate phosphoribosyltransferase activity


inosinic acid pyrophosphorylase activity

inosine 5'-phosphate pyrophosphorylase activity

Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.8, GOC:curators]


Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. [PMID:27471034, PMID:29361132, PMID:29520010]


Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine. [EC:2.4.2.-]


Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine. [EC:2.4.2.-]


Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine. [EC:2.4.2.-]


poly(adenosine diphosphate ribose) polymerase activity

Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]


nicotinic acid phosphoribosyltransferase activity

nicotinic acid mononucleotide pyrophosphorylase activity

Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. [PMID:7503993]

nicotinic acid mononucleotide glycohydrolase activity


quinolinate phosphoribosyltransferase (decarboxylating) activity

nicotinate mononucleotide pyrophosphorylase (carboxylating)

nicotinate-nucleotide diphosphorylase (carboxylating) activity

quinolinic acid phosphoribosyltransferase activity

Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate. [EC:2.4.2.19, RHEA:12733]

nicotinate-nucleotide pyrophosphorylase (carboxylating) activity


nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity

nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity

nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity

Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate. [EC:2.4.2.21, RHEA:11196]


orotic acid phosphoribosyltransferase activity

orotate phosphoribosyl pyrophosphate transferase activity

orotidine monophosphate pyrophosphorylase activity

orotidylic acid pyrophosphorylase activity

Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.10]

orotidine 5'-monophosphate pyrophosphorylase activity


purine nucleoside phosphorylase activity

purine ribonucleoside phosphorylase activity

purine deoxyribonucleoside phosphorylase activity

Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. [EC:2.4.2.1]

purine deoxynucleoside phosphorylase activity


Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. [EC:2.4.2.2]


transfer ribonucleate glycosyltransferase activity

guanine, queuine-tRNA transglycosylase activity

queuine transfer ribonucleate ribosyltransferase activity

Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. [EC:2.4.2.29]


Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. [RHEA:16037]


uridine 5'-phosphate pyrophosphorylase activity

uridine monophosphate pyrophosphorylase activity

Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil. [EC:2.4.2.9, RHEA:13017]


Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. [EC:2.4.2.3]


xanthosine 5'-phosphate pyrophosphorylase activity

Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate. [EC:2.4.2.22, GOC:clt]


Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]


UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity

uridine diphosphoxylose-core protein beta-xylosyltransferase activity

UDP-D-xylose:core protein beta-D-xylosyltransferase activity

UDP-D-xylose:core protein xylosyltransferase activity

UDP-xylose-core protein beta-D-xylosyltransferase activity

Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. [EC:2.4.2.26]

uridine diphosphoxylose-protein xylosyltransferase activity


transferase activity, transferring nitrogenous groups

Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. [ISBN:0198506732]


glutamate-succinic semialdehyde transaminase activity

4-aminobutyric acid aminotransferase activity

gamma-aminobutyric acid aminotransferase activity

gamma-aminobutyric acid transaminase activity

Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. [GOC:mah]


Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate. [UM-BBD_reactionID:r0449]


Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. [EC:2.6.1.11, RHEA:18049]


7,8-diamino-pelargonic acid aminotransferase activity

7-keto-8-aminopelargonic acid aminotransferase activity

7,8-diaminopelargonic acid aminotransferase activity

adenosyl methionine-8-amino-7-oxononanoate transaminase activity

Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate. [EC:2.6.1.62, RHEA:16861]


Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. [EC:2.6.1.44]


aromatic amino acid aminotransferase activity

aromatic amino acid transferase activity

Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate. [EC:2.6.1.57]


Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate. [MetaCyc:R15-RXN]


omega-amino acid--pyruvate aminotransferase activity

Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine. [EC:2.6.1.18]


glutamate-branched-chain amino acid transaminase activity

branched-chain amino acid aminotransferase activity

branched-chain amino acid-glutamate transaminase activity

Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. [EC:2.6.1.42, GOC:mah]

L-branched chain amino acid aminotransferase activity


Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate. [EC:2.6.1.29]


diaminibutyric acid aminotransferase activity

Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate. [EC:2.6.1.76, RHEA:11160]


thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity

thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity

thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity

thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity

Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate. [EC:2.6.1.33]


imidazole acetol-phosphate transaminase activity

histidine:imidazoleacetol phosphate transaminase activity

L-histidinol phosphate aminotransferase activity

glutamic-imidazoleacetol phosphate transaminase activity

Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. [EC:2.6.1.9]


kynurenine 2-oxoglutarate transaminase activity

Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. [EC:2.6.1.7]


Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine. [EC:2.6.1.36, RHEA:21200]


ornithine--oxo acid aminotransferase activity

ornithine ketoacid aminotransferase activity

ornithine--keto acid aminotransferase activity

ornithine--keto acid transaminase activity

Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. [EC:2.6.1.13]


hydroxypyruvic phosphate--glutamic transaminase activity

Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. [EC:2.6.1.52]


Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal. [EC:2.6.1.31, RHEA:10844]


pyridoxamine 5'-phosphate transaminase activity

pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity

pyridoxamine phosphate aminotransferase activity

Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate. [EC:2.6.1.54]


Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. [EC:2.6.1.51, RHEA:22852]


Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate. [EC:2.6.1.17, RHEA:11960]

N-succinyl-L-diaminopimelic glutamic transaminase activity


tyrosine aminotransferase activity
tyrosine transaminase activity


Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine. [EC:2.6.1.66, RHEA:22912]


transferase activity, transferring other nitrogenous groups

OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor). [GOC:ai]


transferase activity, transferring one-carbon groups

Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


Catalysis of the reversible transfer of an amidino group to an acceptor. [GOC:ai]


Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. [RHEA:13201]


L-arginine:inosamine phosphate amidinotransferase activity

Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine. [RHEA:13265]


carboxyl- and carbamoyltransferase activity

carboxyl- or carbamoyltransferase activity

Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). [GOC:jl]


Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate. [EC:6.4.1.6, RHEA:18385]


aspartic acid transcarbamoylase activity

Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. [EC:2.1.3.2, RHEA:20013]


Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. [EC:2.1.3.3]


Catalysis of the transfer of a methyl group to an acceptor molecule. [ISBN:0198506732]


Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene. [UM-BBD_reactionID:r0493]


Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate. [GOC:ai]


Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. [EC:2.1.1.45, RHEA:12104]


Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin. [GOC:ai]


N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity

N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity

Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM. [EC:2.1.1.86, RHEA:53492]


N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity

cobalamin-dependent methionine synthase activity

methionine synthase (cobalamin-dependent) activity

N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity

B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity

N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity

methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity

N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity

B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity

Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine. [EC:2.1.1.13, RHEA:11172]


Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate. [GOC:ai]


methionine synthase (cobalamin-independent) activity

cobalamin-independent methionine synthase activity

methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity

Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. [EC:2.1.1.14, RHEA:21196]


protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity

protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity

S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity

Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. [EC:2.1.2.10]


Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. [GOC:ai]


Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. [RHEA:21128]


quinone cofactor methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1). [GOC:mb]


coenzyme Q biosynthesis methyltransferase activity

coenzyme Q biosynthetic process methyltransferase activity

Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. [GOC:kd, PMID:9083048]


S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity

adenosylmethionine-uroporphyrinogen III methyltransferase activity

Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2. [EC:2.1.1.107]


cyclopropane fatty acid synthetase activity

Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. [EC:2.1.1.79]

cyclopropane fatty acid synthase activity


Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. [PMID:15485916, PMID:20873788, PMID:3042777]

S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity


deoxyribonucleic acid (cytosine-5-)-methyltransferase activity

cytosine-specific DNA methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. [EC:2.1.1.37]


deoxyribonucleic acid methylase activity

deoxyribonucleic acid methyltransferase activity

Catalysis of the transfer of a methyl group to a DNA molecule. [GOC:jl, ISBN:0198506732, PMID:7862522]


N-6 adenine-specific DNA methylase activity

Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. [EC:2.1.1.72]

site-specific DNA-methyltransferase (adenine-specific) activity


N(4)-cytosine-specific DNA methylase activity

site-specific DNA-methyltransferase (cytosine-N4-specific) activity

N4-cytosine-specific DNA methylase activity

Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine. [EC:2.1.1.113]


site-specific DNA-methyltransferase (cytosine-specific) activity


Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. [RHEA:15481]


hydroxymethyl-, formyl- and related transferase activity

Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). [EC:2.1.2.-, GOC:mah]


5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. [EC:2.1.2.11]


Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. [RHEA:15097]

formiminoglutamic acid transferase activity


Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine. [RHEA:24288]


methionyl-transfer RNA transformylase activity

N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity

N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity

formylmethionyl-transfer ribonucleic synthetase activity

methionyl-tRNA Met formyltransferase activity

methionyl ribonucleic formyltransferase activity

Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. [EC:2.1.2.9]


5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity

aminoimidazolecarboxamide ribonucleotide transformylase activity

5-amino-4-imidazolecarboxamide ribotide transformylase activity

5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity

Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. [EC:2.1.2.3]


5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity

glycinamide ribonucleotide transformylase activity

2-amino-N-ribosylacetamide 5'-phosphate transformylase activity

Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. [EC:2.1.2.2]


Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. [EC:2.1.1.114]


Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. [GOC:curators]


Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid. [EC:2.1.1.16]


Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. [GOC:ai]


Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue. [GOC:mah]


Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. [GOC:mah, PMID:12351636, PMID:31284549]


nuclear protein (histone) N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. [PMID:8002954]


cytochrome c-arginine N-methyltransferase activity

[cytochrome c]-arginine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine. [EC:2.1.1.124, GOC:ma]


[myelin basic protein]-arginine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine. [PMID:6177833]

myelin basic protein-arginine N-methyltransferase activity


type IV protein arginine methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine. [EC:2.1.1.322, PMID:9873020]


Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. [EC:2.1.1.20]


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.8, RHEA:19301]


Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. [GOC:mah]


Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. [PMID:12054878]


S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. [EC:2.1.1.60]


histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity

protein (lysine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. [RHEA:10024]


S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity

cytochrome c (lysine) methyltransferase activity

cytochrome c-specific protein-lysine methyltransferase activity

cytochrome c-specific protein methylase III activity

S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity

cytochrome c-lysine N-methyltransferase activity

[cytochrome c]-lysine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c. [EC:2.1.1.59]


messenger ribonucleate guanine 7-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. [EC:2.1.1.56]

messenger RNA guanine 7-methyltransferase activity


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. [EC:2.1.1.1, RHEA:23884]


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine. [EC:2.1.1.7, RHEA:20241]


S-adenosyl methionine:protein-histidine N-methyltransferase activity

protein (histidine) methyltransferase activity

actin-specific histidine methyltransferase activity

Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. [RHEA:19369]


Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. [EC:2.1.1.28]


Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine. [EC:2.1.1.17, RHEA:11164]


Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. [EC:2.1.1.103]


N(2),N(2)-dimethylguanine tRNA methyltransferase activity

tRNA 2,2-dimethylguanosine-26 methyltransferase activity

transfer ribonucleate guanine N2-methyltransferase activity

transfer ribonucleate guanine 2-methyltransferase activity

transfer RNA guanine 2-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. [EC:2.1.1.32]

N2,N2-dimethylguanine tRNA methyltransferase activity


Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. [GOC:ai]


Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9. [GOC:dph]


Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine. [EC:2.1.1.4]


caffeoyl coenzyme A methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA. [EC:2.1.1.104]


Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. [EC:2.1.1.6]

S-COMT (soluble form of catechol-O-methyltransferase)


Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine. [PMID:12135499]

S-adenosyl-methionine:farnesoic acid O-methyltransferase activity


(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity

S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity

Mg-protoporphyrin IX methyltransferase activity

S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity

S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity

magnesium protoporphyrin IX methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H(+) + magnesium protoporphyrin IX 13-monomethyl ester. [EC:2.1.1.11, RHEA:17809]


messenger RNA (nucleoside-2'-)-methyltransferase activity

messenger ribonucleate nucleoside 2'-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. [EC:2.1.1.57]


methyl-accepting chemotaxis protein methyltransferase II

methyl-accepting chemotaxis protein O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. [EC:2.1.1.80, RESID:AA0072]


L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity

protein L-isoaspartate methyltransferase activity

L-isoaspartyl protein carboxyl methyltransferase activity

L-aspartyl/L-isoaspartyl protein methyltransferase activity

protein (D-aspartate) methyltransferase activity

protein L-isoaspartyl methyltransferase activity

protein D-aspartate methyltransferase activity

protein beta-aspartate O-methyltransferase activity

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. [EC:2.1.1.77]


protein C-terminal leucine carboxyl O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein. [PMID:8514774]


S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5. [EC:2.1.1.133]


precorrin-6Y C5,15-methyltransferase (decarboxylating) activity

Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2. [EC:2.1.1.132]


Catalysis of the transfer of a methyl group (CH3-) to a protein. [GOC:jl, ISBN:0198506732]


C-terminal protein carboxyl methyltransferase activity

protein C-terminal carboxyl O-methyltransferase activity

Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. [PMID:8428937]


S-adenosyl methionine-dependent methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. [GOC:mah]


S-adenosylmethionine homocysteine transmethylase activity

Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. [EC:2.1.1.10, GOC:BHF, GOC:dph]


Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. [GOC:mah]


Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. [GOC:mah]


messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. [EC:2.1.1.62]


Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. [GOC:mah]


rRNA (adenine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. [GOC:go-curators]


S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity

Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor. [ISBN:1555811337, PMID:10690410]


ribosomal ribonucleate adenine 6-methyltransferase activity

ribonucleic acid-adenine (N6) methylase activity

ribonucleic acid-adenine (N(6)) methylase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine. [EC:2.1.1.48]


rRNA (cytosine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. [GOC:go-curators]


rRNA (guanine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine. [EC:2.1.1.-]


ribosomal ribonucleate guanine 1-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine. [GOC:curators]


ribosomal ribonucleate guanine-2-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. [EC:2.1.1.52]


rRNA (uridine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine. [GOC:go-curators]


Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. [GOC:mah]


Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. [GOC:mah]


tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity

transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. [EC:2.1.1.61, GOC:imk]


tRNA (adenine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine. [GOC:go-curators]


transfer ribonucleate adenine 1-methyltransferase activity

1-methyladenine transfer RNA methyltransferase activity

transfer RNA (adenine-1) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. [EC:2.1.1.36]


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. [EC:2.1.1.55]


tRNA (cytosine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. [GOC:go-curators]


transfer ribonucleate cytosine 5-methyltransferase activity

transfer RNA cytosine 5-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. [EC:2.1.1.29]


tRNA (guanosine) methyltransferase activity

tRNA (guanine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. [GOC:go-curators]


transfer ribonucleate guanine 1-methyltransferase activity

tRNA guanine 1-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. [EC:2.1.1.31]


7-methylguanine transfer ribonucleate methylase activity

transfer ribonucleate guanine 7-methyltransferase activity

tRNA guanine 7-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. [EC:2.1.1.33]


tRNA guanosine 2'-methyltransferase activity

tRNA (Gm18) 2'-O-methyltransferase activity

transfer ribonucleate guanosine 2'-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine. [EC:2.1.1.34, RHEA:20077]

tRNA (guanosine 2')-methyltransferase activity


tRNA (uridine) methyltransferase activity

tRNA (uracil) methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. [GOC:mah]


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. [EC:2.1.1.96, RHEA:19613]


thiol S-methyltransferase activity
TMT
thiol methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether. [EC:2.1.1.9]


Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. [EC:2.1.1.67]


Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. [GOC:ai]


Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine. [EC:2.1.1.280, PMID:10026151]


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine. [EC:2.1.1.145, RHEA:22200]


methionine synthase cob(II)alamin reductase (methylating) activity

[methionine synthase] reductase activity

methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity

methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)

[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity

Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. [RHEA:23908]


transferase activity, transferring phosphorus-containing groups

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


deoxycytidyl transferase activity, template-dependent


Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). [GOC:jl, PMID:1651917]


inositol phosphoceramide synthase activity

Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol. [PMID:9405490, PMID:9614099]


Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]


CMP-2-keto-3-deoxyoctulosonic acid synthetase activity

cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity

Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. [EC:2.7.7.38]


cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity

cytidine monophosphosialate pyrophosphorylase activity

CMP-N-acetylneuraminic acid synthetase activity

cytidine monophosphosialic acid synthetase activity

cytidine monophosphosialate synthetase activity

cytidine monophosphoacetylneuraminic synthetase activity

CMP-N-acetylneuraminic acid synthase activity

cytidine 5'-monophosphosialic acid synthetase activity

cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity

Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. [EC:2.7.7.43]


adenine triphosphate adenylyltransferase activity

bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity

diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity

dinucleoside oligophosphate alphabeta-phosphorylase activity

diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity

diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)

Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. [EC:2.7.7.53]


cytidine diphosphocholine pyrophosphorylase activity

choline phosphate cytidylyltransferase activity

Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. [EC:2.7.7.15]


terminal deoxynucleotide transferase activity

deoxyribonucleic acid nucleotidyltransferase activity

deoxynucleotidyl terminal transferase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [EC:2.7.7.31]


deoxyribonucleic acid duplicase activity

DNA nucleotidyltransferase (DNA-directed) activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. [EC:2.7.7.7, GOC:vw, ISBN:0198547684]

deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity


DNA polymerase processivity factor activity

An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. [GOC:mah, PMID:7903401, PMID:8087839]


gamma DNA-directed DNA polymerase activity


DNA-dependent ribonucleate nucleotidyltransferase activity

deoxyribonucleic acid-dependent ribonucleic acid polymerase activity

DNA-dependent RNA nucleotidyltransferase activity

nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [EC:2.7.7.6, GOC:pf]

DNA-directed 5'-3' RNA polymerase activity


Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]


OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). [EC:2.7.7.6]


DNA-directed RNA polymerase III activity


Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. [EC:2.7.7.14]

ethanolamine phosphate cytidylyltransferase activity


riboflavin adenine dinucleotide pyrophosphorylase activity

riboflavine adenine dinucleotide adenylyltransferase activity

adenosine triphosphate-riboflavin mononucleotide transadenylase activity

flavin adenine dinucleotide synthetase activity

riboflavin mononucleotide adenylyltransferase activity

Catalysis of the reaction: ATP + FMN = diphosphate + FAD. [EC:2.7.7.2, RHEA:17237]

adenosine triphosphate-riboflavine mononucleotide transadenylase activity


adenosine diphosphate glucose pyrophosphorylase activity

glucose 1-phosphate adenylyltransferase activity

ATP:alpha-glucose-1-phosphate adenylyl transferase activity

Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate. [EC:2.7.7.27, RHEA:12120]

adenosine diphosphoglucose pyrophosphorylase activity


thymidine diphosphate glucose pyrophosphorylase activity

glucose 1-phosphate thymidylyltransferase activity

Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. [EC:2.7.7.24, RHEA:15225]

thymidine diphosphoglucose pyrophosphorylase activity


ATP:glutamine synthetase adenylyltransferase activity

ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity

Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. [EC:2.7.7.42]

adenosine triphosphate:glutamine synthetase adenylyltransferase activity


Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. [GOC:mah]


guanosine diphosphomannose pyrophosphorylase activity

guanosine 5'-diphospho-D-mannose pyrophosphorylase activity

guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. [EC:2.7.7.13, RHEA:15229]

mannose 1-phosphate guanylyltransferase (guanosine triphosphate)


mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity

GDP-mannose 1-phosphate guanylyltransferase activity

mannose-1-phosphate guanylyltransferase (GDP) activity

guanosine diphosphomannose phosphorylase activity

guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate. [EC:2.7.7.22, RHEA:12905]


adenosine triphosphate-nicotinamide mononucleotide transadenylase activity

Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. [EC:2.7.7.1]


nicotinate mononucleotide adenylyltransferase activity

deamidonicotinamide adenine dinucleotide pyrophosphorylase activity

Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. [EC:2.7.7.18]


dephospho-coenzyme A pyrophosphorylase activity

pantetheine phosphate adenylyltransferase activity

Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. [EC:2.7.7.3, RHEA:19801]


cytidine diphosphoglyceride pyrophosphorylase activity

phosphatidic acid cytidylyltransferase activity

CDP diglyceride pyrophosphorylase activity

Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. [EC:2.7.7.41]


terminal riboadenylate transferase activity

adenosine triphosphate:ribonucleic acid adenylyltransferase activity

Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. [EC:2.7.7.19]


nucleoside diphosphate:polynucleotidyl transferase activity

Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate. [EC:2.7.7.8]


Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. [GOC:mah]


GTP--RNA guanylyltransferase activity
mRNA guanylyltransferase activity
GTP:mRNA guanylyltransferase activity

Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. [EC:2.7.7.50]

messenger RNA guanylyltransferase activity


Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. [PMID:1660461]


DNA nucleotidyltransferase (RNA-directed) activity

deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. [EC:2.7.7.49]

RNA-dependent deoxyribonucleate nucleotidyltransferase activity


RNA-directed 5'-3' RNA polymerase activity

ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity

ribonucleic acid-dependent ribonucleic acid polymerase activity

RNA-dependent ribonucleate nucleotidyltransferase activity

RNA nucleotidyltransferase (RNA-directed) activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. [EC:2.7.7.48, GOC:mah, GOC:pf]


Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate. [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN]


sulfate adenylyltransferase (ADP) activity

sulfate (adenosine diphosphate) adenylyltransferase activity

sulphate adenylyltransferase (ADP) activity

adenosine diphosphate sulfurylase activity

Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate. [EC:2.7.7.5, RHEA:16529]


sulphate adenylyltransferase (ATP) activity

sulfate adenylyltransferase (ATP) activity

Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. [EC:2.7.7.4]


transfer ribonucleate adenyltransferase activity

Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1). [RHEA:14433]


Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1). [EC:2.7.7.21]


Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. [EC:2.7.7.56]


hexose 1-phosphate uridyltransferase activity

Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. [EC:2.7.7.12, RHEA:13989]


uridine diphosphoacetylglucosamine pyrophosphorylase activity

uridine diphosphoacetylglucosamine phosphorylase activity

uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity

Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. [EC:2.7.7.23, RHEA:13509]


uridine diphosphoglucose pyrophosphorylase activity

uridine-diphosphate glucose pyrophosphorylase activity

uridine diphosphate-D-glucose pyrophosphorylase activity

uridine 5'-diphosphoglucose pyrophosphorylase activity

Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. [EC:2.7.7.9, RHEA:19889]


alpha-D-galactose 1-phosphate uridylyltransferase activity

uridine diphosphogalactose pyrophosphorylase activity

uridine diphosphate galactose pyrophosphorylase activity

galactose 1-phosphate uridyltransferase activity

Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose. [EC:2.7.7.10, RHEA:14209]


Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). [EC:2.7.7.59]


phosphotransferase activity, alcohol group as acceptor

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). [GOC:jl]


Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.100, RHEA:22312]


Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+). [EC:2.7.1.12, RHEA:19433]


Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. [EC:2.7.1.7]


Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate. [UM-BBD_reactionID:r0155]


enzyme II of the phosphotransferase system

phosphoprotein factor-hexose phosophotransferase activity

Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]


cellobiose transmembrane transporter activity

Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


fructose transmembrane transporter activity

Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


galactitol transmembrane transporter activity

Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


galactosamine transmembrane transporter activity

Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


sorbitol transmembrane transporter activity

Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. [GOC:ai, ISBN:0198506732]


glucose transmembrane transporter activity

Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


lactose transmembrane transporter activity

Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


maltose transmembrane transporter activity

Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


mannitol transmembrane transporter activity

Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


mannose transmembrane transporter activity

Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


N-acetylgalactosamine transmembrane transporter activity

Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


sorbose transmembrane transporter activity

Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


trehalose transmembrane transporter activity

Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


phosphotransferase activity, carboxyl group as acceptor

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). [GOC:jl]


phosphotransferase activity, for other substituted phosphate groups

Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). [GOC:jl]


1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)

Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2. [EC:2.7.8.23]


Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. [GOC:ai]


glycerol 3-phosphate phosphatidyltransferase activity

phosphatidylglycerol phosphate synthetase activity

glycerol phosphate phosphatidyltransferase activity

cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity

phosphatidylglycerol phosphate synthase activity

Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). [EC:2.7.8.5, RHEA:12593]


cytidine diphosphoglyceride-inositol transferase activity

cytidine diphosphoglyceride-inositol phosphatidyltransferase activity

CDP diglyceride-inositol phosphatidyltransferase activity

cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity

cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity

Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+). [EC:2.7.8.11, RHEA:11580]


cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity

cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity

cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity

Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. [EC:2.7.8.8]


cytidine diphosphorylcholine diglyceride transferase activity

1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity

alkylacylglycerol choline phosphotransferase activity

cytidine diphosphocholine glyceride transferase activity

CDP-choline diglyceride phosphotransferase activity

Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. [EC:2.7.8.2, RHEA:32939]

diacylglycerol choline phosphotransferase activity


CDPethanolamine diglyceride phosphotransferase activity

Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. [EC:2.7.8.1, RHEA:32943]


Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein. [GOC:mah, PMID:10037765]


acyl carrier protein holoprotein (holo-ACP) synthetase activity

alpha-aminoadipate reductase phosphopantetheinyl transferase activity

alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity

coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity

alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity

Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]


Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose. [EC:2.7.8.20]


Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group. [GOC:mb]


Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. [GOC:jl, RHEA:31451]


UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity

phospho-N-acetylmuramoyl pentapeptide translocase activity

phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity

UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity

Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. [EC:2.7.8.13]


UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity

lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. [EC:2.7.8.17]


Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein. [GOC:mah, PMID:9353330]


phosphotransferase activity, nitrogenous group as acceptor

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). [GOC:jl]


phosphotransferase activity, paired acceptors

Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors. [GOC:jl]


phosphotransferase activity, phosphate group as acceptor

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). [GOC:jl]


transferase activity, transferring sulphur-containing groups

Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). [GOC:jl]


succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity

3-oxoacid coenzyme A-transferase activity

acetoacetyl coenzyme A-succinic thiophorase activity

acetoacetate succinyl-CoA transferase activity

Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA. [EC:2.8.3.5]

3-ketoacid coenzyme A transferase activity


Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate. [GOC:jl]


butyryl CoA:acetate CoA transferase activity

acetyl-CoA:acetoacetate CoA transferase activity

Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. [EC:2.8.3.8]

succinyl-CoA:acetate CoA transferase activity


Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. [EC:2.8.3.10]


Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA. [EC:2.8.3.12]


propionyl CoA:acetate CoA transferase activity

propionate coenzyme A-transferase activity

Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA. [EC:2.8.3.1]


transferase activity, transferring selenium-containing groups

Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


L-seryl-tRNA(Ser) selenium transferase activity

selenophosphate:L-seryl-tRNASec selenium transferase activity

Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate. [RHEA:22728]

cysteinyl-tRNA(Ser) selenium transferase activity


Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators]


3beta-hydroxy steroid sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. [EC:2.8.2.2]


1-naphthol phenol sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1]


3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. [EC:2.8.2.17]


3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. [EC:2.8.2.4]


heparan sulphate 6-O-sulphotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. [PMID:8631808]

heparan sulfate 6-O-sulfotransferase activity


heparan sulfate 2-O-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. [PMID:9153262]


Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R). [PMID:9478973]


keratan sulfate Gal-6-sulfotransferase activity

keratan sulfate sulfotransferase activity

3'-phosphoadenylyl keratan sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. [EC:2.8.2.21]


Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. [EC:2.8.2.-, GOC:ai]


Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. [GOC:ai, GOC:hjd]


Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate. [EC:2.8.2.-]


Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate. [UM-BBD_reactionID:r0565]


Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate. [UM-BBD_reactionID:r0563]


Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate. [UM-BBD_reactionID:r0561]


Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate. [UM-BBD_reactionID:r0562]


Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate. [UM-BBD_reactionID:r0564]


Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. [EC:2.8.2.20]


Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate. [UM-BBD_reactionID:r0558]


Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate. [UM-BBD_reactionID:r0559]


L-tyrosine methyl ester sulfotransferase activity

Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+). [EC:2.8.2.9, RHEA:19977]


Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). [GOC:ai, ISBN:0721662544]


Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. [EC:2.8.1.2]


Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+). [EC:2.8.1.6, RHEA:22060]


thiosulfate cyanide transsulfurase activity

Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate. [EC:2.8.1.1, RHEA:16881]


OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide. [EC:2.8.1.4]


Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis. [PMID:10583973]


2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity

Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. [EC:2.7.1.160, PMID:9148937]


Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. [GOC:bm, ISBN:0198506732]


Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. [PMID:11983710]


Catalysis of the reaction: versiconal = versicolorin B + H2O. [MetaCyc:RXN-9494, PMID:8784203]


enzyme modulator
catalytic regulator activity

Binds to and modulates the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]


Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]


Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp]


RanGAP
GTPase activator activity
Ran GAP activity
Ran GTPase activator activity

Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]


Binds to and increases the activity of guanylate cyclase. [GOC:mah]


calcium sensitive guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. [GOC:mah]


Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]


Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]


eukaryotic elongation factor-2 kinase activator activity

Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase. [GOC:jl, PMID:11904175]


protein tyrosine kinase activator activity

Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. [GOC:ai, ISBN:0198506732]


receptor signalling protein tyrosine kinase activator activity

receptor signaling protein tyrosine kinase activator activity

Binds to and increases the activity of a receptor signaling protein tyrosine kinase. [GOC:mah]


transmembrane receptor protein tyrosine kinase activator activity

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase. [GOC:mah]


Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]


protein tyrosine phosphatase activator activity

Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. [GOC:ai, ISBN:0198506732]


Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. [GOC:ai]


Increases the activity of the enzyme phospholipase A2. [GOC:ai]


Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. [GOC:ai]


sphingomyelin phosphodiesterase activator activity

Increases the activity of the enzyme sphingomyelin phosphodiesterase. [GOC:ai]


superoxide-generating NADPH oxidase activator activity

Increases the activity of the enzyme superoxide-generating NADPH oxidase. [GOC:ai]


tryptophan hydroxylase activator activity

Increases the activity of the enzyme tryptophase hydroxylase. [GOC:ai]


Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc]


Binds to and stops, prevents or reduces the activity of alpha-amylase. [GOC:mah]


Binds to and stops, prevents or reduces an ATP hydrolysis activity. [GOC:jl]


OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters. [ISBN:0198506732, PMID:11883709]


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. [GOC:mah]


Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase. [GOC:mah]


Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. [GOC:ai]


Stops, prevents or reduces the activity of guanylate cyclase. [GOC:mah]


Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. [GOC:ai, PMID:10482575]


Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]


calcium-dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase. [GOC:mah]


cAMP-dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. [GOC:mah]


cyclin-dependent protein serine/threonine kinase inhibitor activity

cyclin dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:mah, GOC:pr]

cyclin-dependent protein kinase inhibitor activity


diacylglycerol-activated phospholipid-dependent PKC inhibitor activity

diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity

Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. [GOC:ai]


protein serine/threonine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. [GOC:mah]


protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a protein tyrosine kinase. [GOC:mah]


receptor signalling protein tyrosine kinase inhibitor activity

receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase. [GOC:mah]


transmembrane receptor protein tyrosine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase. [GOC:mah]


ornithine decarboxylase inhibitor activity

Binds to and stops, prevents or reduces the activity of ornithine decarboxylase. [GOC:jl]


Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]


phosphoprotein phosphatase inhibitor activity

Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. [GOC:ai]


Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues. [GOC:ajp]


Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. [GOC:ai, GOC:rl]


Binds to and stops, prevents or reduces the activity of phospholipase A2. [GOC:ai]


Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. [GOC:jl]


Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:jl]


aspartic-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. [GOC:ai]


thiol protease inhibitor
cysteine protease inhibitor activity

cysteine-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:dph, GOC:tb]


metalloprotease inhibitor
metalloproteinase inhibitor

Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. [GOC:ai]


serine-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. [GOC:ai]


OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates. [ISBN:0198547684]


protein biosynthetic process inhibitor activity

OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


Binds to and stops, prevents or reduces the activity of ribonuclease. [GOC:ai]


Modulates the activity of guanylate cyclase. [GOC:mah]


Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]


Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]


eukaryotic elongation factor-2 kinase regulator activity

Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase. [GOC:jl, PMID:11904175]


nitric oxide synthase regulator activity

nitric-oxide synthase regulator activity

Binds to and modulates the activity of nitric oxide synthase. [GOC:mah]


Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]


Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. [GOC:ai]


OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation. [GOC:ai, GOC:jl]


OBSOLETE. An agent that can lyse cells. [ISBN:0198547684]


OBSOLETE. An agent that can lyse the cell in which it is synthesized. [GOC:ma]


A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly or indirectly allows murein hydrolyases to access their cell wall substrate. [GOC:jh2, PMID:1406491, PMID:25157079]


OBSOLETE. Acts as to cause lysis of bacterial cells. [GOC:jl]


OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor. [ISBN:0198547684]


OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]


actin filament motor activity
actin-dependent ATPase activity
actin-activated ATPase activity
actin-filament motor activity

A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. [PMID:29716949]


Functions in the storage of nutritious substrates. [GOC:ai]


OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds. [GOC:jid]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation. [GOC:jl]


OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction. [GOC:cl, ISBN:0815316194]


regulator of establishment of competence for transformation activity

OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation. [GOC:mlg]


activator of the establishment of competence for transformation activity

OBSOLETE. Activates the establishment of competence for transformation. [GOC:mlg]


inhibitor of the establishment of competence for transformation activity

OBSOLETE. Inhibits the establishment of competence for transformation. [GOC:mlg]


Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. [GOC:go_curators]


Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis. [GOC:bf, GOC:ma, PMID:6188403]


Combining with an apolipoprotein to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]


OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity. [GOC:mah]


Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446]


complement component C3a receptor activity

Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149]


complement component C3b receptor activity

Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]


Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity. [GOC:ai, GOC:signaling]


U-plasminogen activator receptor activity

Combining with the urokinase plasminogen activator to initiate a change in cell activity. [GOC:mah, PMID:16456079]

urokinase plasminogen activator receptor activity


high molecular weight B lymphocyte growth factor receptor activity

high molecular weight B-cell growth factor receptor activity

high molecular weight B cell growth factor receptor activity

high molecular weight B-lymphocyte growth factor receptor activity

Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:2681271]


ligand-dependent nuclear receptor binding

Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974]


OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor. [PMID:7776974]

ligand-dependent thyroid hormone receptor interactor activity


Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:10506570]


non-kinase phorbol ester receptor activity

Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity. [PMID:10506570]


The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. [GOC:ai, GOC:go_curators]


The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. [GOC:tb]


G protein coupled photoreceptor activity

photoreceptor activity, G-protein coupled

G-protein coupled photoreceptor activity

G protein-coupled photoreceptor activity

Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, ISBN:0198506732]


OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin. [ISBN:0198547684]


OBSOLETE. An opsin with maximal absorption above 500 nm. [PMID:10594055]


OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]


OBSOLETE. An opsin with maximal absorption between 400 and 500 nm. [PMID:10594055]


OBSOLETE. An opsin with maximal absorption below 400 nm. [PMID:10594055]


red/far-red light photoreceptor activity

red or far-red light photoreceptor activity

The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation. [GOC:lr]


Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein]


receptor activity involved in axon guidance

Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]


Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:dph, GOC:signaling, PMID:15960985]


OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]


Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:lr, GOC:signaling]


G-protein coupled cytokinin receptor activity

cytokinin receptor activity, G-protein coupled

G protein coupled cytokinin receptor activity

G protein-coupled cytokinin receptor activity

Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph]


Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]


death receptor-associated factor activity


tumor necrosis factor-activated receptor activity

Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. [GOC:jl, http://lookwayup.com/]


OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity. [GOC:ai]


Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. [GOC:ai]


Binding to a signal recognition particle. [ISBN:0198506732]


OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity. [GOC:ai]


receptor activity, G-protein coupled
GPCR activity
G protein-coupled receptor activity
G protein coupled receptor activity
G-protein coupled receptor activity
G protein linked receptor activity
ligand-dependent GPCR activity

Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]


Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]


Epstein-Barr Virus-induced receptor activity


Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732]


Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732]


Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. [GOC:ai, ISBN:0198506732]


Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, GOC:mah, PMID:18670432]


super conserved receptor expressed in brain receptor activity


adenylyl cyclase inhibiting metabotropic glutamate receptor activity

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. [GOC:bf, GOC:dph]


group II metabotropic glutamate receptor activity

A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. [GOC:dph]


group III metabotropic glutamate receptor activity

A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. [PMID:9016303]


group I metabotropic glutamate receptor activity


Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior. [GOC:hjd, ISBN:0198506732]


mating-type factor pheromone receptor activity

Combining with a mating-type factor pheromone to initiate a change in cell activity. [GOC:dph, GOC:vw]


mating-type a-factor pheromone receptor activity

Combining with the mating-type a-factor pheromone to initiate a change in cell activity. [GOC:mah]


mating-type alpha-factor pheromone receptor activity

Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity. [GOC:mah]


Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]


Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]


Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]


Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]


Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]


Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]


Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]


Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]


Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]


Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist. [GOC:ai]


G-protein coupled serotonin receptor activity

G protein-coupled serotonin receptor activity

Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai]

G protein coupled serotonin receptor activity


serotonin receptor activity, coupled via Gi/o

Gi/o-coupled serotonin receptor activity

Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels. [GOC:mah, PMID:18571247]


Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. [GOC:mah, PMID:19325074]


Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine. [GOC:curators]


Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid]


Combining with an icosanoid to initiate a change in cell activity. [GOC:dph]


Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. [ISBN:0198506732]


PGI receptor activity
prostaglandin I receptor activity
PGI(2) receptor activity

Combining with prostacyclin (PGI(2)) to initiate a change in cell activity. [ISBN:0198506732]


Combining with a prostaglandin (PG) to initiate a change in cell activity. [ISBN:0198506732]


prostaglandin D receptor activity
PGD receptor activity

Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. [ISBN:0198506732]


PGE(2) receptor activity
prostaglandin E receptor activity

Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. [ISBN:0198506732]


PGF(2-alpha) receptor activity
PGF receptor activity

Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. [ISBN:0198506732]


Combining with a thromboxane (TXA) to initiate a change in cell activity. [ISBN:0198506732]


thromboxane A2 receptor activity
TXA(2) receptor activity

Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein. [GOC:signaling, ISBN:0198506732]